{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CER7","uniProtkbId":"G5CER7_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":51,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48304.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Cytochrome c oxidase subunit 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"7.1.1.9"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48304.1"}],"value":"cox1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001971"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004673"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Energy metabolism; oxidative phosphorylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Belongs to the heme-copper respiratory oxidase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":472,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":553,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit I profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50855"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48304.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48304.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48304.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48304.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48304.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351176.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CER7","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816582","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00705","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01663","properties":[{"key":"EntryName","value":"Cyt_c_Oxidase_I"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.210.10:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.210.10","properties":[{"key":"EntryName","value":"Cytochrome c oxidase-like, subunit I domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023616","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_dom"}]},{"database":"InterPro","id":"IPR036927","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_sf"}]},{"database":"InterPro","id":"IPR000883","properties":[{"key":"EntryName","value":"Cyt_C_Oxase_1"}]},{"database":"InterPro","id":"IPR023615","properties":[{"key":"EntryName","value":"Cyt_c_Oxase_su1_BS"}]},{"database":"InterPro","id":"IPR033944","properties":[{"key":"EntryName","value":"Cyt_c_oxase_su1_dom"}]},{"database":"PANTHER","id":"PTHR10422","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10422:SF18","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00115","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01165","properties":[{"key":"EntryName","value":"CYCOXIDASEI"}]},{"database":"SUPFAM","id":"SSF81442","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit I-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50855","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00077","properties":[{"key":"EntryName","value":"COX1_CUB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MYKYDFVENIRQRLNNYIPGYNSLSNWIERWLWSSNAKDIGTLYLIVALLSGLVGTAFSVLIRLELSGPGVQFIADNQLYNSIITAHAIVMIFFMVMPAMIGGFGNFLLPLIVGGPDMVYPRLNNISFWLLPPSLILFLFASGIENGAGTGWTLYPPLSGIQSHSGPSVDLAIFSLHLAGISSLLGAMNFITTILNMRSPGIRLHKLALFGWAVVTTAVLLLLSLPVLAGAITMILTDRNFNTSFFETAGGGDPILYQHLFWFFGHPEVYILIIPGFGVISTTISASSNKSVFGYLGMVYAIMSIGVLGFVVWSHHMYSVGLDVDTRAYFTAATLIIAVPTGIKIFSWLATCYGGSLQLTPPMLFALGFVFMFTVGGLSGVVLANASLDIAFHDTYYVVAHFHYVLSMGAVFALYSAWYFWIPKILGLNFKISWGIIHFWVLFLGVNVTFFPQHFLGLQGMPRRISDYPDAFAGWNLISSLGSIISVGATWLFLHILYVQLVEGNATSRYPWLTVPFNVDTLQSHLTRAYNSLEWCLSSPPKPHAFVSLPLQSSFETTLMVLKSSMGPNEFGVVLDQIVSGGIFVASLFIKTMYSADHLSPDMLEPITMINKPVDIVDNIYRTYAGV","length":627,"molWeight":69163,"crc64":"CEBBE56B24900881","md5":"01E98A8548C9AED81B443CE8EB35F07E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":12,"Domain":1},"uniParcId":"UPI00022AB57F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CEQ3","uniProtkbId":"G5CEQ3_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":30,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48290.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"NADH-ubiquinone oxidoreductase chain 6"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48290.1"}],"value":"nad6"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Belongs to the complex I subunit 6 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48290.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48290.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48290.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48290.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48290.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351162.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CEQ3","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816589","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"1.20.120.1200","properties":[{"key":"EntryName","value":"NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001457","properties":[{"key":"EntryName","value":"NADH_UbQ/plastoQ_OxRdtase_su6"}]},{"database":"InterPro","id":"IPR042106","properties":[{"key":"EntryName","value":"Nuo/plastoQ_OxRdtase_6_NuoJ"}]},{"database":"PANTHER","id":"PTHR33269","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33269:SF17","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00499","properties":[{"key":"EntryName","value":"Oxidored_q3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFATICVIINKNPIVSVLFLIFLFIIIASYLITLGLSYIGLSYLLVYVGAVSILFLFILMLINVRISELLSNTGNSILLAIVIAICFIYTVNQVLPDSLAAYSNYIDYLSSLFYGIRFSVEYINYVFKILNINNYTSPSLVTSNIWDGSLGETTHITAIGNIMYTGYMMWLIEVSVLLLVAMVGSILITIKKSEMELKSSGTELDISGVIYGMNIDTAFRRRDSHT","length":226,"molWeight":25231,"crc64":"BFEB661807A3BE08","md5":"3A4B0AAE5E8D048CAF8F852DEC1CCAD1"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":4},"uniParcId":"UPI00022AB571"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CEQ4","uniProtkbId":"G5CEQ4_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":42,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48291.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"value":"Cytochrome c oxidase subunit 3"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48291.1"}],"value":"cox3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010581"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"value":"Belongs to the cytochrome c oxidase subunit 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Heme-copper oxidase subunit III family profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50253"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48291.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48291.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48291.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48291.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48291.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351163.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CEQ4","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816592","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd01665","properties":[{"key":"EntryName","value":"Cyt_c_Oxidase_III"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.70:FF:000082","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.80:FF:000002","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.80","properties":[{"key":"EntryName","value":"Cytochrome c oxidase, subunit III, four-helix bundle"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024791","properties":[{"key":"EntryName","value":"Cyt_c/ubiquinol_Oxase_su3"}]},{"database":"InterPro","id":"IPR033945","properties":[{"key":"EntryName","value":"Cyt_c_oxase_su3_dom"}]},{"database":"InterPro","id":"IPR000298","properties":[{"key":"EntryName","value":"Cyt_c_oxidase-like_su3"}]},{"database":"InterPro","id":"IPR035973","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su3-like_sf"}]},{"database":"InterPro","id":"IPR013833","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su3_a-hlx"}]},{"database":"PANTHER","id":"PTHR11403:SF7","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11403","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT III"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00510","properties":[{"key":"EntryName","value":"COX3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81452","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit III-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50253","properties":[{"key":"EntryName","value":"COX3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTMITRSHFQAHPFHLVSPSPWPINTCISLLTLTTSGVLSMHGFIIALNFLNIALIALISSMTLWFRDVISESTYQGFHTLAVQRGINMGVGLFIVSEALFFLAIFWTFFHSALSPTIELGAKWPPLGVDSINPFELPLLNTIILLSSGFTVTYAHHCIIQGNRSGALYGLILTVTLAFFFTVLQAAEYSVSSFTISDSSFGSCFYFGTGFHGLHVMIGTAFIAVGLWRVLAYHCTDNHHLGLESSILYWHFVDIVWLFLFISMYYWGS","length":269,"molWeight":30027,"crc64":"9FC4FD31C10FD2E9","md5":"10A4D52BE944B6FEF818E6C1BE142A11"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":6,"Domain":1},"uniParcId":"UPI00022AB572"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CEQ8","uniProtkbId":"G5CEQ8_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":30,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48295.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021008"}],"value":"NADH-ubiquinone oxidoreductase chain 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"}],"value":"7.1.1.2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031028"}],"value":"NADH dehydrogenase subunit 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48295.1"}],"value":"nad2"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007012"}],"value":"Belongs to the complex I subunit 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48295.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48295.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48295.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48295.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48295.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351167.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CEQ8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816575","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"HAMAP","id":"MF_00445","properties":[{"key":"EntryName","value":"NDH1_NuoN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010096","properties":[{"key":"EntryName","value":"NADH-Q_OxRdtase_suN/2"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"PANTHER","id":"PTHR22773","properties":[{"key":"EntryName","value":"NADH DEHYDROGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIIYSILSLLLSNAATLRRDMSILYSRVAIIILLHCISIAFCSLFIYKSLCKGIGLFGGLFHATSLTQIFHIFIFLLSAIILQLTAFYPRKVWIKEYSSLSNIWTKFFYDKTEIINKMGQQFKIIEYPLIILFIITGAIFLVSTSDIVSIFISIELQSYGLYLLSTLYRNSELSTSAGLTYFLLGGLSSCFILLGTSLLYANSGTTNLDGFYIITSLSNIANQDYISNVIYWYKPFYINISLLIMSVGFLFKVSAAPFHFWSPDVYDALPTIVTTFVAIIAKISILIFLLELVHYTSNCLFSYKFSWTYSLLISSLLSLIIGTVLGLTQFRIKRLFAYSTISHLGFILLALSINSIESIQAFIFYLMQYSISNLNAFILLISIGYSLYPFIYDDSVNSSMTNKEQYLKLLDRNNSPIQLISQIKGYFYINPVLALSLAITLFSLVGIPPLIGFFAKQMVLSAALDSGYVFLTLIAILTSVVSAVYYLGVLKQIFFDKPEYKLNPAFENVTLYGSVITVNHPLLLKKK","length":527,"molWeight":59458,"crc64":"E50172F6D6FE3595","md5":"0AC9E7C83F0A253DE5D65AF8C58E0353"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":12,"Domain":1},"uniParcId":"UPI00022AB576"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CEQ9","uniProtkbId":"G5CEQ9_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":52,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48296.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021007"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"NADH-ubiquinone oxidoreductase chain 3"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48296.1"}],"value":"nad3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003257"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008472"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Belongs to the complex I subunit 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]},{"type":"Transmembrane","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]},{"type":"Transmembrane","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48296.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48296.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48296.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48296.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351168.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CEQ9","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816576","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030964","properties":[{"key":"GoTerm","value":"C:NADH dehydrogenase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"FunFam","id":"1.20.58.1610:FF:000009","properties":[{"key":"EntryName","value":"NADH-ubiquinone oxidoreductase chain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1610","properties":[{"key":"EntryName","value":"NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000440","properties":[{"key":"EntryName","value":"NADH_UbQ/plastoQ_OxRdtase_su3"}]},{"database":"InterPro","id":"IPR038430","properties":[{"key":"EntryName","value":"NDAH_ubi_oxred_su3_sf"}]},{"database":"PANTHER","id":"PTHR11058","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11058:SF9","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00507","properties":[{"key":"EntryName","value":"Oxidored_q4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSTILFFIFIPLLAFILLAVNLIFAPHNPYKEKDSVFECGFHSFLGQNRTQFSISFFIFALLFLLFDLEILLVYPYIVSAYTNGIYGLVIMLIFFIVLTLGFAFELGKKALSIDSRQVSVVSDNKQSSIINKIK","length":135,"molWeight":15350,"crc64":"9E3CD38EE7CBE3B3","md5":"7EC308A6325E302642387D0C2E721714"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":3},"uniParcId":"UPI00022AB577"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CER0","uniProtkbId":"G5CER0_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":37,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48297.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016612"}],"value":"NADH-ubiquinone oxidoreductase chain 4L"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"}],"value":"7.1.1.2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031586"}],"value":"NADH dehydrogenase subunit 4L"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48297.1"}],"value":"nad4L"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003257"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010519"}],"value":"Belongs to the complex I subunit 4L family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48297.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48297.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48297.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48297.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48297.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351169.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CER0","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816577","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030964","properties":[{"key":"GoTerm","value":"C:NADH dehydrogenase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.10.287.3510:FF:000004","properties":[{"key":"EntryName","value":"NADH-ubiquinone oxidoreductase chain 4L"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.3510","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01456","properties":[{"key":"EntryName","value":"NDH1_NuoK"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001133","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_chain4L/K"}]},{"database":"InterPro","id":"IPR039428","properties":[{"key":"EntryName","value":"NUOK/Mnh_C1-like"}]},{"database":"NCBIfam","id":"NF004320","properties":[{"key":"EntryName","value":"nuoK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11434:SF16","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11434","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00420","properties":[{"key":"EntryName","value":"Oxidored_q2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNLSLILFLIGILGFVLNRKNIILMLISIEIMLLAITLLILVSSLSFDDILGQTYAVYVIAIAGAESAIGLGILVAFYRLRGSIAIEYK","length":89,"molWeight":9702,"crc64":"4D72B8AEDE826B58","md5":"94ADBC194166783CA89D690FBED4A026"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":2},"uniParcId":"UPI00022AB578"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CER2","uniProtkbId":"G5CER2_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":58,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48299.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021096"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"NADH-ubiquinone oxidoreductase chain 5"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48299.1"}],"value":"nad5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003257"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"Belongs to the complex I subunit 5 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":471,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":511,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":639,"modifier":"EXACT"},"end":{"value":658,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Domain","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00662"}]},{"type":"Domain","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]},{"type":"Domain","location":{"start":{"value":504,"modifier":"EXACT"},"end":{"value":629,"modifier":"EXACT"}},"description":"NADH dehydrogenase subunit 5 C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF06455"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48299.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48299.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48299.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48299.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351171.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CER2","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816578","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.5.2700","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010934","properties":[{"key":"EntryName","value":"NADH_DH_su5_C"}]},{"database":"InterPro","id":"IPR018393","properties":[{"key":"EntryName","value":"NADHpl_OxRdtase_5_subgr"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"InterPro","id":"IPR003945","properties":[{"key":"EntryName","value":"NU5C-like"}]},{"database":"InterPro","id":"IPR001516","properties":[{"key":"EntryName","value":"Proton_antipo_N"}]},{"database":"NCBIfam","id":"TIGR01974","properties":[{"key":"EntryName","value":"NDH_I_L"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF005141","properties":[{"key":"EntryName","value":"nuoL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42829","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42829:SF2","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06455","properties":[{"key":"EntryName","value":"NADH5_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00662","properties":[{"key":"EntryName","value":"Proton_antipo_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01434","properties":[{"key":"EntryName","value":"NADHDHGNASE5"}]}],"sequence":{"value":"MYLAIIILPLLGSIVSGFFGRRIGVGGAQIVTCVSVIVTTLLAIIAFFEVGLKDIPVSIQIFRWIESGSLVVLLGFQFDALTVSMLIPVLIVSSLVHIYSIGYMSHDPHNQRFFCYLSLFTFMMIILVTANNFLLMFIGWEGVGICSYLLVGFWFTRIAANLSSMSAFLTNRVGDCFLTLGMFAILWSFGNIDYSTVFSLAPYVSENIVTIIGICFLIGAMAKSSQIGLHIWLPMAMEGPTPVSALIHAATMVTAGVYLLMRTAPLIEYSSTVLILCLWVGAITTIFSSLIGLFQQDIKKVIAYSTMSQLGMMVIAVGLSSYNIALFHLINHAFYKGLLFLGAGAVIHSLADNQDFRKYGGLRPFLPLTYSVMLIASLSLVAFPFMTGFYSKDFILESAYGQFYFSTTVVYFIATIGAMFTTLYSVKVLYLTFLTNPNGPLINYKQAHEGNIFICLPLIILAVFSIFFGYITKDIFIGLGSGFFSDNSLFIHPTHEIMLDTEFAVPSLFKLLPLAFTLTVCAISLVLSEFLPNILISFKFTRVGYNIFSFFNLRFLFELLYNKYITRLVLKLGGQTTRVLDKGSVELLGPYGLEKGLLKISNNLGSLDTGVITSYALYILIGLIYYILMAYLSLTHSSLLLLIMFSLFVYFFFEKVQVKGKGSL","length":664,"molWeight":73693,"crc64":"718043AE543B8CC1","md5":"99598B49247D7D021D21699DAFE5BE38"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":15,"Domain":3},"uniParcId":"UPI00022AB57A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CER4","uniProtkbId":"G5CER4_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":39,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48301.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"NADH-ubiquinone oxidoreductase chain 4"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48301.1"}],"value":"nad4"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003257"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009025"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Belongs to the complex I subunit 4 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Domain","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48301.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48301.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48301.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48301.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48301.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351173.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CER4","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816579","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0048039","properties":[{"key":"GoTerm","value":"F:ubiquinone binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR010227","properties":[{"key":"EntryName","value":"NADH_Q_OxRdtase_chainM/4"}]},{"database":"InterPro","id":"IPR003918","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"NCBIfam","id":"TIGR01972","properties":[{"key":"EntryName","value":"NDH_I_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43507","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43507:SF1","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01437","properties":[{"key":"EntryName","value":"NUOXDRDTASE4"}]}],"sequence":{"value":"MLLLFLLGIPITGILIVFIYINASWHDRLDFSLNKRIKYTGLTTSIVNLFLSFIIFIGFDFSSNQFQFVREYHQISYFDFYLGVDGLSIYFLLLTTIITPISLLSNWTSISENIGSYVIIMLLLETLLLFVFLVLDILLFYIFFESILPPLFILIGFFGSNNRVRACFYLFLYTLLGSLFLLLSIVTMSSIMGTTDFDALYKTNFQYFSQLFLFFGIFIAFAVKTPTIFLNTWLLKAHVESPLGGSIILAGIVLKLSLYGILRLILPLLPKAYLDYTYLVYLIGVISIIYASVNTLRTIDVKELIAYSSVSHASVYLLGVFSNTIQGIEGGITLGLGHGFASSGLFICAGGVLYDRSSTRLITYYRGMSQIMPLFSIIYFILCLGNVGTPLTLNFIGEFLSLYGIFERLPIVGALACSSILLSAAYTINMFTKICFAGSFSKFFISNIPDLNKREFYILFTLVAFTIIFGVYPSPILDGLHYNVSCLIYQA","length":491,"molWeight":55241,"crc64":"FB0CF08167DEF3B0","md5":"316F7B54B60E626BB9E2D4346335084D"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":14,"Domain":1},"uniParcId":"UPI00022AB57C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CER5","uniProtkbId":"G5CER5_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":40,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48302.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000442"}],"value":"DNA polymerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000442"}],"value":"2.7.7.7"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48302.1"}],"value":"dpoB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22508"},{"database":"Rhea","id":"RHEA-COMP:17339"},{"database":"Rhea","id":"RHEA-COMP:17340"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61560"},{"database":"ChEBI","id":"CHEBI:173112"}],"ecNumber":"2.7.7.7","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049244"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000442"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005755"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000442"}],"value":"Belongs to the DNA polymerase type-B family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":627,"modifier":"EXACT"}},"description":"DNA-directed DNA polymerase family B mitochondria/virus","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03175"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48302.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000442"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000442"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022932"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000442"}],"id":"KW-0239","category":"Molecular function","name":"DNA-directed DNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48302.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000442"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000442"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48302.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48302.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48302.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351174.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CER5","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816580","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003887","properties":[{"key":"GoTerm","value":"F:DNA-directed DNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0000166","properties":[{"key":"GoTerm","value":"F:nucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006260","properties":[{"key":"GoTerm","value":"P:DNA replication"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.287.690","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1600.10","properties":[{"key":"EntryName","value":"Palm domain of DNA polymerase"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.420.10","properties":[{"key":"EntryName","value":"Ribonuclease H-like superfamily/Ribonuclease H"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006172","properties":[{"key":"EntryName","value":"DNA-dir_DNA_pol_B"}]},{"database":"InterPro","id":"IPR017964","properties":[{"key":"EntryName","value":"DNA-dir_DNA_pol_B_CS"}]},{"database":"InterPro","id":"IPR004868","properties":[{"key":"EntryName","value":"DNA-dir_DNA_pol_B_mt/vir"}]},{"database":"InterPro","id":"IPR015833","properties":[{"key":"EntryName","value":"DNA-dir_DNA_pol_B_mt_lin_plsmd"}]},{"database":"InterPro","id":"IPR043502","properties":[{"key":"EntryName","value":"DNA/RNA_pol_sf"}]},{"database":"InterPro","id":"IPR023211","properties":[{"key":"EntryName","value":"DNA_pol_palm_dom_sf"}]},{"database":"InterPro","id":"IPR012337","properties":[{"key":"EntryName","value":"RNaseH-like_sf"}]},{"database":"InterPro","id":"IPR036397","properties":[{"key":"EntryName","value":"RNaseH_sf"}]},{"database":"PANTHER","id":"PTHR33568","properties":[{"key":"EntryName","value":"DNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33568:SF3","properties":[{"key":"EntryName","value":"DNA-DIRECTED DNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03175","properties":[{"key":"EntryName","value":"DNA_pol_B_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF006517","properties":[{"key":"EntryName","value":"DPol_mt_plasmid"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00486","properties":[{"key":"EntryName","value":"POLBc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56672","properties":[{"key":"EntryName","value":"DNA/RNA polymerases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53098","properties":[{"key":"EntryName","value":"Ribonuclease H-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00116","properties":[{"key":"EntryName","value":"DNA_POLYMERASE_B"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MYIYNECIIVNYNPVKKDISTVYHREVYSSNTGVLYFIVEDTVKNLNYPNVFTRKIGNSIFNISSDKITGFEVNKELACISNKHREYKAASNPFIGTLDLETYHDTDGFSKVYALGFYVDGGDPVIFYIEKGESSHSLVLRCFDALLINKYNNYIFYIHNLGGYDGPFILNILRQANLDKGFEYYKLSYLFRDNKLIKLSIKLNVLPVSTVTKDVGSNNNNKSYNKDDQSIKDSNIKITLYDSFKLLNNNLYDLSVDFEVSVTKGSFPHEFVKKDTLFYIGNTPHIDYWKDITKKEYKNKLFKVDLNLKVECINYLKKYLISLYQVLSIFNKYVFEKYGVQMTDSLTISRLAMNIFLKKYLKDFKLPVIKQNMYKDIKQSYFGGITEVYKPYGENLYYYDVNSLYPYASLNSMPGSNCTYIERSDINIDTLFGFYYCEIETTDNYLGLLPVHRDFELIMPNGKWNGWYFSEQLKFAQQNGYKVKVTRGYSFNREDNVFNHYVSDLYKVKSNNTGSIKVIAKSLLNNLLGRFGLNVYKPVTKIVNEDTFNFIISAYDVNSFTKISDDDDYLITYYPEVNKNTCISHNLDYTKVLNSNKVNVGKLKEFNDVSLSTASAVTAYARIHMGKIKLDIINKGGQIYYSDTDSIVTDISLDEKIVGKDIGQFKLEYKVKKGFFISSKLYFLVLHDAYVTKKIRV","length":697,"molWeight":80799,"crc64":"D7F99FDDD03CE563","md5":"6AC1CD4AB0CD1C6329BACC450C3527BD"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI00022AB57D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CER6","uniProtkbId":"G5CER6_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":40,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48303.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"value":"NADH-ubiquinone oxidoreductase chain 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48303.1"}],"value":"nad1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010535"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Belongs to the complex I subunit 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48303.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48303.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48303.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48303.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48303.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351175.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CER6","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816581","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0009060","properties":[{"key":"GoTerm","value":"P:aerobic respiration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"HAMAP","id":"MF_01350","properties":[{"key":"EntryName","value":"NDH1_NuoH"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001694","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_su1/FPO"}]},{"database":"InterPro","id":"IPR018086","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_su1_CS"}]},{"database":"PANTHER","id":"PTHR11432","properties":[{"key":"EntryName","value":"NADH DEHYDROGENASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11432:SF3","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00146","properties":[{"key":"EntryName","value":"NADHdh"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00667","properties":[{"key":"EntryName","value":"COMPLEX1_ND1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00668","properties":[{"key":"EntryName","value":"COMPLEX1_ND1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLYLPIVISIIEVLTVTISVLIGVAFVTIAERKTMASMQRRLGPNIVGYYGLLQAFADALKLLLKEYISPTQANIILFFLGPIITLNFSLLGYAVIPFGPGLALLDFNLGILYILAVSSLSTYGILLAGWSANSKYAFLGSLRSTAQLISYELILSSAVLLVILLTGSLNLTVNIESQRAIWYIIPLLPIFIIFLIGSIAETNRAPFDLAEAESELVSGFMTEHAAVIFVFFFLAEYASIVLICTLISILFLGGYLFSSDIMFFVLFGVIDSIQFLDFYLYISVFLTVFDIFDTLNDPMFEGIFYGLILGLKTCIMFFVFVWARASFPRIRFDQLMSFCWTVLLPIIIGFIILVPCILYSFDIIPSNVSLF","length":371,"molWeight":41352,"crc64":"AB0948B9AC58663D","md5":"34A32B8B54B83C990CAACDC5C5118020"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":8},"uniParcId":"UPI00022AB57E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CES6","uniProtkbId":"G5CES6_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":57,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48313.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Cytochrome b"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48313.1"}],"value":"cytb"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"heme b","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:60344"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Binds 2 heme groups non-covalently."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"value":"Binds 2 heme groups non-covalently."}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061233"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16389"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-1"}],"ligand":{"name":"a ubiquinone","id":"ChEBI:CHEBI:16389"}},{"type":"Non-terminal residue","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48313.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48313.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48313.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48313.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48313.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351185.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CES6","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816583","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045275","properties":[{"key":"GoTerm","value":"C:respiratory chain complex III"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00290","properties":[{"key":"EntryName","value":"cytochrome_b_C"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.810.10:FF:000002","properties":[{"key":"EntryName","value":"Cytochrome b"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR036150","properties":[{"key":"EntryName","value":"Cyt_b/b6_C_sf"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR030689","properties":[{"key":"EntryName","value":"Cytochrome_b"}]},{"database":"InterPro","id":"IPR048260","properties":[{"key":"EntryName","value":"Cytochrome_b_C_euk/bac"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00032","properties":[{"key":"EntryName","value":"Cytochrom_B_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038885","properties":[{"key":"EntryName","value":"COB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81648","properties":[{"key":"EntryName","value":"a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRIFKSHPLLKLVNSYVIDSPQPSNLSYLWNFGSLLSFCLIIQIVTGVTLAMHYSPTISEAFNSVEHIMRDVNNGWLIRYLHSNTASAFFFLVYLHIGRGLYYGSYRAPRTLVWTIGTVLFILMIATAFLGYVLPYGQMSLWGATVITNLMSAIPWVGQDIVEFIWGGFSVNNATLNRFFALHFVLPFVLAALALMHLIVLHDRAGSGNPLGVSGNYDRLPFAPYFIFKDLITIFIFILGLSVFVFFMPNILGDSENYVMANPMQTPPAIVPEWYLLPFYAILRSIPNKLLGVIAMFSAIVILLAMPFTDLSRSRGIQFRPLSKAAFFIFVGNFLILMQLGAKHVESPFIEFGQISTVLYFSHFLIIVPLISLLENSLIELASKKNTNTNTNTQIYQTSAKSAQDLNKLLKEDININLDLTFSLVLFLFIVYCLTNWND","length":439,"molWeight":49574,"crc64":"9544205ADF6CAFDF","md5":"A8BA8641B80BA5EDCF221A903585816C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":9,"Domain":2,"Binding site":5,"Non-terminal residue":1},"uniParcId":"UPI00022AB588"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CES7","uniProtkbId":"G5CES7_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":59,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48314.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015946"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Cytochrome c oxidase subunit 2"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48314.1"}],"value":"cox2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Cu cation","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:23378"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Binds a copper A center."}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007866"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Belongs to the cytochrome c oxidase subunit 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit II transmembrane region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50999"}]},{"type":"Domain","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit II copper A binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50857"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48314.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48314.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48314.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48314.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48314.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351186.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CES7","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816553","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005507","properties":[{"key":"GoTerm","value":"F:copper ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd13912","properties":[{"key":"EntryName","value":"CcO_II_C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.90:FF:000004","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.420:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.90","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.420","properties":[{"key":"EntryName","value":"Cupredoxins - blue copper proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045187","properties":[{"key":"EntryName","value":"CcO_II"}]},{"database":"InterPro","id":"IPR002429","properties":[{"key":"EntryName","value":"CcO_II-like_C"}]},{"database":"InterPro","id":"IPR034210","properties":[{"key":"EntryName","value":"CcO_II_C"}]},{"database":"InterPro","id":"IPR001505","properties":[{"key":"EntryName","value":"Copper_CuA"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR014222","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2"}]},{"database":"InterPro","id":"IPR011759","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2_TM_dom"}]},{"database":"InterPro","id":"IPR036257","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2_TM_sf"}]},{"database":"NCBIfam","id":"TIGR02866","properties":[{"key":"EntryName","value":"CoxB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22888:SF9","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22888","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE, SUBUNIT II"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00116","properties":[{"key":"EntryName","value":"COX2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02790","properties":[{"key":"EntryName","value":"COX2_TM"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01166","properties":[{"key":"EntryName","value":"CYCOXIDASEII"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81464","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit II-like, transmembrane region"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00078","properties":[{"key":"EntryName","value":"COX2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50857","properties":[{"key":"EntryName","value":"COX2_CUA"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50999","properties":[{"key":"EntryName","value":"COX2_TM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"IHLFSTLLYCDAPRPWGLYFQDSATPQMEGLVELHDNIMFYLSIILFSVGWILISIIIKFNNKKWPIANKYLSHGTLIELIWTITPALILILIAFPSFKLLYLMDEVSDPAMVVLAEGHQWYWSYQYPDFLNSDDEFIEFDSYLIPESDLEEGTLRMLEVDNRVIIPELTHVSFMVTGADVIHSYACPSLGIKCDAYPGRLNQVSVFINREGTFYGQCSEICGILHSSMPIVIESVSIEKFITWLQEQ","length":248,"molWeight":28490,"crc64":"190F050EC438CAC9","md5":"3F2DDFC6EB432FF2F8FAF0E6F1C8E525"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":2,"Domain":2,"Non-terminal residue":1},"uniParcId":"UPI00022AB589"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CES9","uniProtkbId":"G5CES9_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":43,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48316.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019317"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"ATP synthase subunit 9, mitochondrial"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48316.1"}],"value":"atp9"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003897"}],"value":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011648"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006704"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"Belongs to the ATPase C chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}]},{"type":"Transmembrane","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}]},{"type":"Domain","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"V-ATPase proteolipid subunit C-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00137"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48316.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022547"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023121"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0446","category":"Ligand","name":"Lipid-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48316.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48316.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48316.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351188.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CES9","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816550","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0033177","properties":[{"key":"GoTerm","value":"C:proton-transporting two-sector ATPase complex, proton-transporting domain"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015078","properties":[{"key":"GoTerm","value":"F:proton transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015986","properties":[{"key":"GoTerm","value":"P:proton motive force-driven ATP synthesis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd18182","properties":[{"key":"EntryName","value":"ATP-synt_Fo_c_ATP5G3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.20.10:FF:000009","properties":[{"key":"EntryName","value":"ATP synthase subunit 9, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.20.10","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit C"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01396","properties":[{"key":"EntryName","value":"ATP_synth_c_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000454","properties":[{"key":"EntryName","value":"ATP_synth_F0_csu"}]},{"database":"InterPro","id":"IPR020537","properties":[{"key":"EntryName","value":"ATP_synth_F0_csu_DDCD_BS"}]},{"database":"InterPro","id":"IPR038662","properties":[{"key":"EntryName","value":"ATP_synth_F0_csu_sf"}]},{"database":"InterPro","id":"IPR002379","properties":[{"key":"EntryName","value":"ATPase_proteolipid_c-like_dom"}]},{"database":"InterPro","id":"IPR035921","properties":[{"key":"EntryName","value":"F/V-ATP_Csub_sf"}]},{"database":"PANTHER","id":"PTHR10031","properties":[{"key":"EntryName","value":"ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10031:SF0","properties":[{"key":"EntryName","value":"ATPASE PROTEIN 9"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00137","properties":[{"key":"EntryName","value":"ATP-synt_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00124","properties":[{"key":"EntryName","value":"ATPASEC"}]},{"database":"SUPFAM","id":"SSF81333","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit C"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00605","properties":[{"key":"EntryName","value":"ATPASE_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIQAAKIIGTGLATTGLIGAGVGIGVVFGALILGVARNPAIKGQLFAYAILGFAFSEATGLFALMMAFLLLFVV","length":74,"molWeight":7459,"crc64":"19A4AC7B18BBFA50","md5":"AA95B3D36F2D4A7BC0463AC6AF710EAD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":2,"Domain":1},"uniParcId":"UPI00022AB58B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CET0","uniProtkbId":"G5CET0_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":36,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48317.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"ATP synthase protein 8"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48317.1"}],"value":"atp8"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024864"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011291"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004167"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004167"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008892"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Belongs to the ATPase protein 8 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48317.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023310"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022547"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48317.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48317.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48317.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48317.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351189.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CET0","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816557","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046933","properties":[{"key":"GoTerm","value":"F:proton-transporting ATP synthase activity, rotational mechanism"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR009230","properties":[{"key":"EntryName","value":"ATP_synth_su8_fun"}]},{"database":"PANTHER","id":"PTHR36101","properties":[{"key":"EntryName","value":"ATP SYNTHASE PROTEIN 8"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36101:SF1","properties":[{"key":"EntryName","value":"ATP SYNTHASE PROTEIN 8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05933","properties":[{"key":"EntryName","value":"Fun_ATP-synt_8"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPQLIPFYFTDQVTFTFILLTVMVYVFSKYILPRFVRLFLTRLFISKL","length":48,"molWeight":5868,"crc64":"7FC77902832D2050","md5":"CC2F1E9F062D41EB6D99C01EBCA9E68D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":1},"uniParcId":"UPI00022AB58C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CET1","uniProtkbId":"G5CET1_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":41,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48318.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021312"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004450"}],"value":"ATP synthase subunit a"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48318.1"}],"value":"atp6"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004450"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004450"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006810"}],"value":"Belongs to the ATPase A chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48318.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023310"}],"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022547"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48318.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48318.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48318.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48318.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351190.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CET1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816558","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046933","properties":[{"key":"GoTerm","value":"F:proton-transporting ATP synthase activity, rotational mechanism"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00310","properties":[{"key":"EntryName","value":"ATP-synt_Fo_a_6"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.220:FF:000003","properties":[{"key":"EntryName","value":"ATP synthase subunit a"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.220","properties":[{"key":"EntryName","value":"ATP synthase, F0 complex, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01393","properties":[{"key":"EntryName","value":"ATP_synth_a_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000568","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu"}]},{"database":"InterPro","id":"IPR023011","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu_AS"}]},{"database":"InterPro","id":"IPR045083","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu_bact/mt"}]},{"database":"InterPro","id":"IPR035908","properties":[{"key":"EntryName","value":"F0_ATP_A_sf"}]},{"database":"NCBIfam","id":"TIGR01131","properties":[{"key":"EntryName","value":"ATP_synt_6_or_A"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF004482","properties":[{"key":"EntryName","value":"PRK05815.2-4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11410","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11410:SF0","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00119","properties":[{"key":"EntryName","value":"ATP-synt_A"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00123","properties":[{"key":"EntryName","value":"ATPASEA"}]},{"database":"SUPFAM","id":"SSF81336","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00449","properties":[{"key":"EntryName","value":"ATPASE_A"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTSHNFNYILNPLDQFSIRSYISLDAPVLAYTYISVTNIAIYLTIATIIALTVNILATNYNKVVSNGWSISQESVYATVHSIVINQINAKKGQLYFPFIYTLFIFILINNLIGMIPYSFASTSHFILTFSISFTVVLGATILGLTKHGFKFFSLFVPAGCPLSLLPLLVLIEFISYIARNISLGLRLAANILSGHMLLNILSGFAYNILLSGFIYIFVGLIPLAFIIAFSGLELGIAFIQSQVFVVLTSSYIKDAVDLH","length":259,"molWeight":28605,"crc64":"16B12AAFD5CD9DAB","md5":"D5C91DB25FB88E85863D278547BA5D95"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":5},"uniParcId":"UPI00022AB58D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"J7JNY3","uniProtkbId":"J7JNY3_9LECA","entryAudit":{"firstPublicDate":"2012-10-31","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2012-10-31","entryVersion":49,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFQ55280.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"value":"DNA-directed RNA polymerase subunit beta"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"value":"2.7.7.6"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFQ55280.1"}],"value":"rpbII"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"value":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21248"},{"database":"Rhea","id":"RHEA-COMP:14527"},{"database":"Rhea","id":"RHEA-COMP:17342"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61557"},{"database":"ChEBI","id":"CHEBI:140395"}],"ecNumber":"2.7.7.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048552"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011730"}],"value":"Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006835"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000434"}],"value":"Belongs to the RNA polymerase beta chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"RNA polymerase beta subunit protrusion","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04563"}]},{"type":"Domain","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04561"}]},{"type":"Domain","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":564,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04565"}]},{"type":"Domain","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04566"}]},{"type":"Domain","location":{"start":{"value":703,"modifier":"EXACT"},"end":{"value":774,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04567"}]},{"type":"Domain","location":{"start":{"value":781,"modifier":"EXACT"},"end":{"value":1153,"modifier":"EXACT"}},"description":"DNA-directed RNA polymerase subunit 2 hybrid-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00562"}]},{"type":"Domain","location":{"start":{"value":1155,"modifier":"EXACT"},"end":{"value":1247,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04560"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022478"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0240","category":"Cellular component","name":"DNA-directed RNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFQ55280.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX181774","properties":[{"key":"ProteinId","value":"AFQ55280.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"J7JNY3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003899","properties":[{"key":"GoTerm","value":"F:DNA-directed RNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0032549","properties":[{"key":"GoTerm","value":"F:ribonucleoside binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00653","properties":[{"key":"EntryName","value":"RNA_pol_B_RPB2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.150:FF:000002","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1100.10:FF:000005","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1110.10:FF:000003","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1800.10:FF:000002","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.150","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1070.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1100.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.270.10","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase, subunit 2, domain 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1800.10","properties":[{"key":"EntryName","value":"RNA polymerase alpha subunit dimerisation domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1110.10","properties":[{"key":"EntryName","value":"RNA polymerase Rpb2, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR015712","properties":[{"key":"EntryName","value":"DNA-dir_RNA_pol_su2"}]},{"database":"InterPro","id":"IPR007120","properties":[{"key":"EntryName","value":"DNA-dir_RNAP_su2_dom"}]},{"database":"InterPro","id":"IPR037033","properties":[{"key":"EntryName","value":"DNA-dir_RNAP_su2_hyb_sf"}]},{"database":"InterPro","id":"IPR007121","properties":[{"key":"EntryName","value":"RNA_pol_bsu_CS"}]},{"database":"InterPro","id":"IPR007644","properties":[{"key":"EntryName","value":"RNA_pol_bsu_protrusion"}]},{"database":"InterPro","id":"IPR007642","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"}]},{"database":"InterPro","id":"IPR037034","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2_sf"}]},{"database":"InterPro","id":"IPR007645","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"}]},{"database":"InterPro","id":"IPR007646","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_4"}]},{"database":"InterPro","id":"IPR007647","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_5"}]},{"database":"InterPro","id":"IPR007641","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_7"}]},{"database":"InterPro","id":"IPR014724","properties":[{"key":"EntryName","value":"RNA_pol_RPB2_OB-fold"}]},{"database":"PANTHER","id":"PTHR20856","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04563","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04561","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04565","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04566","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04567","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00562","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04560","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_7"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64484","properties":[{"key":"EntryName","value":"beta and beta-prime subunits of DNA dependent RNA-polymerase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01166","properties":[{"key":"EntryName","value":"RNA_POL_BETA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAYDPYDDSYLDEDEEATITAEDCWTVISSFFDSKGLVSQQLDSFDEFVSTTMQELVAENSVLTLDQNAPPSDSDDPILIRRYEIKFGTVLLSRPAMTEGDGSTSTMLPQEARLRNLTYSSPLYLEMTKKVSIARERVVFENADEDPNPDSDAQKRFGADANLDWVIEDGDDDQDPSKVFVGKLPIMLKSKYCILKDLGEAELYNWNECPYDQGGYFVINGSEKVLIAQERSAANIVQVFKKAPPSATPYVAEIRSAVEKGSRLISSMQIKLFAKGENHKGGFGQTVKATLPYVKTDVPIGIVFRALGIVSDEDILNHICYDRNDTQMLEKLKPCIEEAFVIQDREVALDWIGSRGNSQSLSRPKRVKYARDIMQKELLPHISQTDGSETKKAFFLGYMVHRMLQCALGRREVDDRDHFGKKRLDLAGPLLAGLFRMLFNKLTKDVFKYLQKCVENNREFNLTLGVKSTTLTNGLKYSLATGNWGDQKKAASSKAGVSQVLNRYTFASTLSHLRRTNTPIGRDGKIAKPRQLHNTHWGLVCPAETPEGQACGLVKNLALMCYITVGTPCEPIIDFMNQRNMEMLEEYEPLRSPNATKVFVNGVWVGVHRDPAHLVSNVQDLRRGHIISHEVSLVRDIRDREFKIFTDAGRVCRPLFVIDNDTRSMNYGNLVLTKEHIARLEEDKEAAIGMDRDELEARQMGWDGLVNQGVVEYVDAEEEETVMIVMTPGDLETSRQIQLGKAVPGNAEDEPNKRVNAMSHRSAQTWTHCEIHPSMILGICASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYDQRMDTMANILYYPQKPMATTRSMEFLKFRELPAGQNAIVAIACYSGYNQEDSVIMNQSSIDRGLFRSLFYRSYTDQEKRIGMSIVEQFEKPMRTDTLRLKHGTYEKLDDDGIVAPGVRVSGEDMIIGKTAPIPPDSEELGQRTKLHVKRDASTPLRSTENGIVDQVLLTTNAEGLRFVKVRMRTTKIPQIGDKFASRHGQKGTIGITYRQEDMPFTSEGVVPDLIINPHAIPSRMTIAHLIECQLSKVSALRGFEGDATPFTEVTVDSVSKILRAHGYQSRGFEVMYNAHTGLKLVAQVFLGPTYYQRLRHMVDDKIHARARGPVQILTRQPVEGRARDGGLRFGEMERDCMIAHGASAFLKERLFEVSDAFRVHICDICGLMTPVANLKKNSFECRPCKNKTRISQVHIPYAAKLLFQELASMNIAARMYTTRSGLSVR","length":1255,"molWeight":141157,"crc64":"E9EE6870EF1EB160","md5":"13023F0EFFE6B7DFC7A1206921FD9051"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":7},"uniParcId":"UPI00027EE7C0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"J7JPY4","uniProtkbId":"J7JPY4_9LECA","entryAudit":{"firstPublicDate":"2012-10-31","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-10-31","entryVersion":40,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFQ55278.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013870"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"value":"Elongation factor 1-alpha"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFQ55278.1"}],"value":"EF1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"value":"This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007249"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"value":"Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"Tr-type G","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51722"}]},{"type":"Region","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"G1","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}]},{"type":"Region","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"G2","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}]},{"type":"Region","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"G3","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}]},{"type":"Region","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"G4","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}]},{"type":"Region","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"G5","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022768"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"id":"KW-0251","category":"Molecular function","name":"Elongation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022481"}],"id":"KW-0488","category":"PTM","name":"Methylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFQ55278.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX181772","properties":[{"key":"ProteinId","value":"AFQ55278.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"J7JPY4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003746","properties":[{"key":"GoTerm","value":"F:translation elongation factor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd01883","properties":[{"key":"EntryName","value":"EF1_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd03693","properties":[{"key":"EntryName","value":"EF1_alpha_II"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd03705","properties":[{"key":"EntryName","value":"EF1_alpha_III"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.30.10:FF:000003","properties":[{"key":"EntryName","value":"Elongation factor 1-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.30.10:FF:000005","properties":[{"key":"EntryName","value":"Elongation factor 1-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000211","properties":[{"key":"EntryName","value":"Elongation factor 1-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.30.10","properties":[{"key":"EntryName","value":"Translation factors"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_00118_A","properties":[{"key":"EntryName","value":"EF_Tu_A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004161","properties":[{"key":"EntryName","value":"EFTu-like_2"}]},{"database":"InterPro","id":"IPR031157","properties":[{"key":"EntryName","value":"G_TR_CS"}]},{"database":"InterPro","id":"IPR054696","properties":[{"key":"EntryName","value":"GTP-eEF1A_C"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR000795","properties":[{"key":"EntryName","value":"T_Tr_GTP-bd_dom"}]},{"database":"InterPro","id":"IPR050100","properties":[{"key":"EntryName","value":"TRAFAC_GTPase_members"}]},{"database":"InterPro","id":"IPR009000","properties":[{"key":"EntryName","value":"Transl_B-barrel_sf"}]},{"database":"InterPro","id":"IPR009001","properties":[{"key":"EntryName","value":"Transl_elong_EF1A/Init_IF2_C"}]},{"database":"InterPro","id":"IPR004539","properties":[{"key":"EntryName","value":"Transl_elong_EF1A_euk/arc"}]},{"database":"NCBIfam","id":"TIGR00483","properties":[{"key":"EntryName","value":"EF-1_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF008969","properties":[{"key":"EntryName","value":"PRK12317.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23115","properties":[{"key":"EntryName","value":"TRANSLATION FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22594","properties":[{"key":"EntryName","value":"GTP-eEF1A_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00009","properties":[{"key":"EntryName","value":"GTP_EFTU"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03144","properties":[{"key":"EntryName","value":"GTP_EFTU_D2"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00315","properties":[{"key":"EntryName","value":"ELONGATNFCT"}]},{"database":"SUPFAM","id":"SSF50465","properties":[{"key":"EntryName","value":"EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50447","properties":[{"key":"EntryName","value":"Translation proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00301","properties":[{"key":"EntryName","value":"G_TR_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51722","properties":[{"key":"EntryName","value":"G_TR_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGKEKMHINVVVIGHVDSGKSTTTGHLIYKCGGIDRRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAINKMDTTKWSEDRYNEIIKETSNFIKKVGYNPKTVPFVPISGFNGDNMIEVSSNCPWYKGWEKETKTKTSGKTLLEAIDAIDPPSRPTDKALRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVTFAPANVTTEVKSVEMHHEQLTEGLPGDNVGFNVKNVSVKEIRRGNVAGDSKNDPPKGADSFNAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFSELLEKIDRRSGKSIENTPKFIKSGDAAIVKMVPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVVKSEKAGGKVTKAAVKASGKK","length":459,"molWeight":49994,"crc64":"235E172E4EDFCD8B","md5":"4F5FAC622A7755DA6BD2763B802F2CCC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":5},"uniParcId":"UPI00027EE7BE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C7AZW1","uniProtkbId":"C7AZW1_9LECA","entryAudit":{"firstPublicDate":"2009-09-22","lastAnnotationUpdateDate":"2025-10-08","lastSequenceUpdateDate":"2009-09-22","entryVersion":42,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09188.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"DNA-directed RNA polymerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"2.7.7.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09188.1"}],"value":"rpb1"}}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"RNA polymerase Rpb1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04997"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09188.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09188.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022478"}],"id":"KW-0240","category":"Cellular component","name":"DNA-directed RNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"19453383","citationType":"journal article","authors":["O'Brien H.E.","Miadlikowska J.","Lutzoni F."],"citationCrossReferences":[{"database":"PubMed","id":"19453383"},{"database":"DOI","id":"10.1111/j.1558-5646.2009.00685.x"}],"title":"Assessing reproductive isolation in highly diverse communities of the lichen-forming fungal genus peltigera.","publicationDate":"2009","journal":"Evolution","firstPage":"2076","lastPage":"2086","volume":"63"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09197.1"}],"value":"HOB020708-31-1-2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09188.1"}],"value":"HOB020708-31-1-4","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09189.1"}],"value":"HOB020708-31-5-4","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09190.1"}],"value":"HOB020708-35-1-2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09191.1"}],"value":"HOB020708-35-1-3","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09196.1"}],"value":"HOB020708-35-1-4","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09192.1"}],"value":"HOB020708-70-5-4","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09193.1"}],"value":"HOB020708-70-5-5","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09194.1"}],"value":"HOB040605-4-2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09195.1"}],"value":"HOB040605-7-4","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09188.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"FJ709216","properties":[{"key":"ProteinId","value":"ACU09188.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709217","properties":[{"key":"ProteinId","value":"ACU09189.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709218","properties":[{"key":"ProteinId","value":"ACU09190.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709219","properties":[{"key":"ProteinId","value":"ACU09191.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709220","properties":[{"key":"ProteinId","value":"ACU09192.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709221","properties":[{"key":"ProteinId","value":"ACU09193.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709222","properties":[{"key":"ProteinId","value":"ACU09194.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709223","properties":[{"key":"ProteinId","value":"ACU09195.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709224","properties":[{"key":"ProteinId","value":"ACU09196.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709225","properties":[{"key":"ProteinId","value":"ACU09197.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"C7AZW1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005665","properties":[{"key":"GoTerm","value":"C:RNA polymerase II, core complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003899","properties":[{"key":"GoTerm","value":"F:DNA-directed RNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR045867","properties":[{"key":"EntryName","value":"DNA-dir_RpoC_beta_prime"}]},{"database":"InterPro","id":"IPR007080","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_1"}]},{"database":"PANTHER","id":"PTHR19376","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19376:SF37","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04997","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64484","properties":[{"key":"EntryName","value":"beta and beta-prime subunits of DNA dependent RNA-polymerase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TKIKKLLETVCHNCGKILLDESNADFKNALRFRDPKRRFDAIWKACKPKMVCDMMPVADDGIPDKSQEPKHDHGGCGNIQPEIRKEGLKLTGTWKARKEDEDPQDEKRPITPQNALNIFRHISSEEIQRMGLNVDYARPEWMIITVLPVPPPPVRPSIAVDGGNGMRGEDDLTYKLGDIIRANGNVRTCEAEGSPAHVVA","length":200,"molWeight":22403,"crc64":"2CDED64F5ABA9370","md5":"3971DD8731112789328BBE8A949DF105"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0001B18EEC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"C7B0G3","uniProtkbId":"C7B0G3_9LECA","entryAudit":{"firstPublicDate":"2009-09-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-09-22","entryVersion":48,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09390.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09390.1"}],"value":"Beta-tubulin"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09390.1"}],"value":"TUBB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009636"}],"value":"Belongs to the tubulin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Tubulin/FtsZ GTPase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00091"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09390.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09390.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"19453383","citationType":"journal article","authors":["O'Brien H.E.","Miadlikowska J.","Lutzoni F."],"citationCrossReferences":[{"database":"PubMed","id":"19453383"},{"database":"DOI","id":"10.1111/j.1558-5646.2009.00685.x"}],"title":"Assessing reproductive isolation in highly diverse communities of the lichen-forming fungal genus peltigera.","publicationDate":"2009","journal":"Evolution","firstPage":"2076","lastPage":"2086","volume":"63"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09402.1"}],"value":"HOB020708-31-1-2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09401.1"}],"value":"HOB020708-31-1-3","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09390.1"}],"value":"HOB020708-31-1-4","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09391.1"}],"value":"HOB020708-31-5-4","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09392.1"}],"value":"HOB020708-35-1-2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09393.1"}],"value":"HOB020708-35-1-3","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09394.1"}],"value":"HOB020708-70-5-3","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09395.1"}],"value":"HOB020708-70-5-4","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09396.1"}],"value":"HOB020708-70-5-5","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09397.1"}],"value":"HOB020708-70-5-6","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09398.1"}],"value":"HOB040605-3-2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09399.1"}],"value":"HOB040605-4-2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09400.1"}],"value":"HOB040605-7-4","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACU09390.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"FJ709418","properties":[{"key":"ProteinId","value":"ACU09390.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709419","properties":[{"key":"ProteinId","value":"ACU09391.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709420","properties":[{"key":"ProteinId","value":"ACU09392.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709421","properties":[{"key":"ProteinId","value":"ACU09393.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709422","properties":[{"key":"ProteinId","value":"ACU09394.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709423","properties":[{"key":"ProteinId","value":"ACU09395.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709424","properties":[{"key":"ProteinId","value":"ACU09396.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709425","properties":[{"key":"ProteinId","value":"ACU09397.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709426","properties":[{"key":"ProteinId","value":"ACU09398.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709427","properties":[{"key":"ProteinId","value":"ACU09399.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709428","properties":[{"key":"ProteinId","value":"ACU09400.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709429","properties":[{"key":"ProteinId","value":"ACU09401.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"FJ709430","properties":[{"key":"ProteinId","value":"ACU09402.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"C7B0G3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005874","properties":[{"key":"GoTerm","value":"C:microtubule"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007017","properties":[{"key":"GoTerm","value":"P:microtubule-based process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.1440","properties":[{"key":"EntryName","value":"Tubulin/FtsZ, GTPase domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000217","properties":[{"key":"EntryName","value":"Tubulin"}]},{"database":"InterPro","id":"IPR036525","properties":[{"key":"EntryName","value":"Tubulin/FtsZ_GTPase_sf"}]},{"database":"InterPro","id":"IPR003008","properties":[{"key":"EntryName","value":"Tubulin_FtsZ_GTPase"}]},{"database":"PANTHER","id":"PTHR36527","properties":[{"key":"EntryName","value":"OS01G0282866 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36527:SF3","properties":[{"key":"EntryName","value":"OS01G0282866 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00091","properties":[{"key":"EntryName","value":"Tubulin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01161","properties":[{"key":"EntryName","value":"TUBULIN"}]},{"database":"SUPFAM","id":"SSF52490","properties":[{"key":"EntryName","value":"Tubulin nucleotide-binding domain-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VHLQTGQCGNQIGAAFWQIISGEHGLDGAGVYNGTSDLQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFR","length":82,"molWeight":8855,"crc64":"61E62A455F13656C","md5":"E841D71AAB1CD415AF8D4D1660C6F678"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0001B18FB2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CEQ5","uniProtkbId":"G5CEQ5_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2011-12-14","entryVersion":19,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48292.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48292.1"}],"value":"Uncharacterized protein"}}]},"features":[{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48292.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48292.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48292.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48292.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48292.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351164.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CEQ5","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11935114","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MERERQEELKNTIEDAEKNLKEVEKALEHDKNLPENRKHNNRHLNHIKDEFSSYLDKKTGSDVTQSLKEIEAMLKEEIDSLKIDIYGDQVDKDTDQPDSPAKTDKAENNDKTDKPENQDKINQPVKSYETTDKYDKSDENINQPKDKKDPFFIEEEMPGFLDDLD","length":165,"molWeight":19354,"crc64":"85F5400EAAE69637","md5":"448F89D1187E059E6D41E3AA11AD7B9A"},"extraAttributes":{"countByFeatureType":{"Region":2,"Compositional bias":5},"uniParcId":"UPI00022AB573"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CEQ6","uniProtkbId":"G5CEQ6_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2011-12-14","entryVersion":30,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48293.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48293.1"}],"value":"Orf813"}}],"flag":"Fragment"},"features":[{"type":"Domain","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"GIY-YIG","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50164"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48293.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48293.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48293.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48293.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48293.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48293.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351165.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CEQ6","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816564","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd10445","properties":[{"key":"EntryName","value":"GIY-YIG_bI1_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1440.10","properties":[{"key":"EntryName","value":"GIY-YIG endonuclease"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000305","properties":[{"key":"EntryName","value":"GIY-YIG_endonuc"}]},{"database":"InterPro","id":"IPR035901","properties":[{"key":"EntryName","value":"GIY-YIG_endonuc_sf"}]},{"database":"InterPro","id":"IPR006350","properties":[{"key":"EntryName","value":"Intron_endoG1"}]},{"database":"NCBIfam","id":"TIGR01453","properties":[{"key":"EntryName","value":"grpIintron_endo"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01541","properties":[{"key":"EntryName","value":"GIY-YIG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00465","properties":[{"key":"EntryName","value":"GIYc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82771","properties":[{"key":"EntryName","value":"GIY-YIG endonuclease"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50164","properties":[{"key":"EntryName","value":"GIY_YIG"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"AVDITNLIIIKVTKFNSSNNNLISNATLVSPVKTYKNSEVLKSQVLNDNNNKSGIYCWTNYLNGKTYVGSGINLAKRLTSYYNRNELNRNPRPITESLLKYGYHNFTLDILEYCSEDKLIEREQFYLNILVPEYNILKYANSLLGFKHSKETIEKLKQRVISSEHKELLSLVHKGKVVSQETKNKLASATTNYKKDNPLTPEALANIKAKTIAREGVSVSVLNNKTKELKEFTTQTEAGQFLGITRQAIHNAIKRGTLVNEMYHITKKQK","length":270,"molWeight":30732,"crc64":"65AE7334944BB21A","md5":"BF2EB0B636D3ACE4A9964400362B0005"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI00022AB574"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CEQ7","uniProtkbId":"G5CEQ7_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":29,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48294.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00035157"}],"value":"Small ribosomal subunit protein uS3m"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48294.1"}],"value":"rps3"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010761"}],"value":"Belongs to the universal ribosomal protein uS3 family"}],"commentType":"SIMILARITY"}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48294.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48294.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023274"}],"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022980"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48294.1"}],"id":"KW-0689","category":"Molecular function","name":"Ribosomal protein"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48294.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48294.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48294.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351166.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CEQ7","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816565","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003735","properties":[{"key":"GoTerm","value":"F:structural constituent of ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006412","properties":[{"key":"GoTerm","value":"P:translation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR007980","properties":[{"key":"EntryName","value":"Ribosomal_uS3m_fun"}]},{"database":"Pfam","id":"PF05316","properties":[{"key":"EntryName","value":"VAR1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLNIFNLKLNNSNFFVTKKEKIDNKSNDRGQTRHYPPANREWFNSIYAYNKNTSKLLHVADKAILILIKSYFNLYSADLEKTKKTRRTRRFRRLSVNRILISRAELKHTSDKVIITIYIYNRHLKYYLNKIKTIATLNILKKKLSKQKLQIIVNNGLKITSNVLKQKKILFETLNIGNNKFNNYGNNYVNKYLKIFIFKCLHEEMLYLNLKQIIFVNKSKFNCNYLLPLSSLIAKIYKKKIEFNIVNLKYLYLNSYIFTETLVTKIKNRKNRVLRVLKASLSMFKLPPLNKLAIFDDMYNRKKKAQNLKVNHVLSNPNFMLFNKGLRLQQQGKGLGKGKGKGKGINSISNNSDYDTLDLILSKVYSKNLLQNKLVNIDITKKKEHVTNTVLCSIKHKSVSGIRIEAAGRLTRRNTAERSAYKLRYKGNIRNEDSSFKGLSTVILRGHAKSNLQYTKLKSKKKIGSFGLKGWISSN","length":475,"molWeight":55313,"crc64":"1F276B7AC4EA334F","md5":"AC04A50A3BF98905715C4AA6708F39FF"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"uniParcId":"UPI00022AB575"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CER1","uniProtkbId":"G5CER1_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":27,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48298.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48298.1"}],"value":"Orf453"}}],"flag":"Fragment"},"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]},{"type":"Domain","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48298.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48298.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48298.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48298.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48298.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48298.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351170.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CER1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816577","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.10.28.10","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR027434","properties":[{"key":"EntryName","value":"Homing_endonucl"}]},{"database":"InterPro","id":"IPR004860","properties":[{"key":"EntryName","value":"LAGLIDADG_dom"}]},{"database":"PANTHER","id":"PTHR36181:SF3","properties":[{"key":"EntryName","value":"INTRON-ENCODED DNA ENDONUCLEASE AI5 BETA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36181","properties":[{"key":"EntryName","value":"INTRON-ENCODED ENDONUCLEASE AI3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00961","properties":[{"key":"EntryName","value":"LAGLIDADG_1"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF55608","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"FRVSTIKDIINIIIPHFDNYPLITKKSSDYILFKQVALLMLNKEHNNLEGLQKIVNLRAFLNLGLSKDLKEAYPEVVPIKKSNNFTEAMFNNLSPEWVAGFSTGESNFFITVQKSKTKSSLAVWLRFSIGQHSRDPSSPMVLLISLVVVM","length":150,"molWeight":17029,"crc64":"723EE8E728CBBAD4","md5":"A95E125A7E271EF5F11BD7B2021908F6"},"extraAttributes":{"countByFeatureType":{"Domain":2,"Non-terminal residue":1},"uniParcId":"UPI00022AB579"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CER3","uniProtkbId":"G5CER3_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-12-14","entryVersion":27,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48300.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48300.1"}],"value":"Orf1200"}}],"flag":"Fragment"},"features":[{"type":"Domain","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00961"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48300.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48300.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48300.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48300.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48300.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48300.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351172.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CER3","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816578","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.10.28.10","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR027434","properties":[{"key":"EntryName","value":"Homing_endonucl"}]},{"database":"InterPro","id":"IPR004860","properties":[{"key":"EntryName","value":"LAGLIDADG_dom"}]},{"database":"PANTHER","id":"PTHR37520","properties":[{"key":"EntryName","value":"INTRON-ENCODED DNA ENDONUCLEASE AI2A-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR37520:SF1","properties":[{"key":"EntryName","value":"INTRON-ENCODED DNA ENDONUCLEASE AI2A-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00961","properties":[{"key":"EntryName","value":"LAGLIDADG_1"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF55608","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"ARECNTHSITFRHQTICVEVIFNILNQIINMINSQITKAHDYLINSHNSYNLFNSSLIHWLYYYILKFVIMSVRWKIIIISKSVGISEAIRLILIFIKLNLINLTQNPSILSIFFFSYILQAIYVFIEINIIYYCASNVKISANYNINTNATIQVNNSGNNVNNDKDLSFKQWLAGLIDGDGYFLLTKKGYNSCEITMDARDKKALYEIKHKYGGSIKQVSNANAYKYKLRHRAGLILLIKDVNGLIRNPTRLLQMNKICVKFSIQLKYPNPLTFNDGWLSGFIDSDGSVYFNEASGQVFIGISQKNRYLLEPLISIYGGRVDILSPKIEAFKFIIYRKAELFNLIDNYFNKYPLKTEKMKRINLIKQFYLLRIHRKSQDINKFNEWVKFKDRWEKFQD","length":399,"molWeight":46705,"crc64":"1910D93230C9BE91","md5":"598FDFAD0F4C5450DE867E2EF5AF12F7"},"extraAttributes":{"countByFeatureType":{"Domain":2,"Non-terminal residue":1},"uniParcId":"UPI00022AB57B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G5CER8","uniProtkbId":"G5CER8_9LECA","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2011-12-14","entryVersion":27,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Peltigera malacea","taxonId":52884,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48305.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Peltigerales","Peltigerineae","Peltigeraceae","Peltigera"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48305.1"}],"value":"Orf966"}}]},"features":[{"type":"Domain","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"GIY-YIG","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50164"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48305.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48305.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"}],"references":[{"referenceNumber":1,"citation":{"id":"22749167","citationType":"journal article","authors":["Xavier B.B.","Miao V.P.","Jonsson Z.O.","Andresson O.S."],"citationCrossReferences":[{"database":"PubMed","id":"22749167"}],"title":"Mitochondrial genomes from the lichenized fungi Peltigera membranacea and Peltigera malacea: Features and phylogeny.","publicationDate":"2012","journal":"Fungal Biol.","firstPage":"802","lastPage":"814","volume":"116"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48305.1"}],"value":"DB3992","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEK48305.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN088164","properties":[{"key":"ProteinId","value":"AEK48305.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_005351177.1","properties":[{"key":"NucleotideSequenceId","value":"NC_016955.1"}]},{"database":"AlphaFoldDB","id":"G5CER8","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"11816582","properties":[{"key":"Description","value":"-"}]},{"database":"CDD","id":"cd10445","properties":[{"key":"EntryName","value":"GIY-YIG_bI1_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1440.10","properties":[{"key":"EntryName","value":"GIY-YIG endonuclease"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000305","properties":[{"key":"EntryName","value":"GIY-YIG_endonuc"}]},{"database":"InterPro","id":"IPR035901","properties":[{"key":"EntryName","value":"GIY-YIG_endonuc_sf"}]},{"database":"InterPro","id":"IPR010896","properties":[{"key":"EntryName","value":"NUMOD1"}]},{"database":"Pfam","id":"PF01541","properties":[{"key":"EntryName","value":"GIY-YIG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07453","properties":[{"key":"EntryName","value":"NUMOD1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00465","properties":[{"key":"EntryName","value":"GIYc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82771","properties":[{"key":"EntryName","value":"GIY-YIG endonuclease"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50164","properties":[{"key":"EntryName","value":"GIY_YIG"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLNKKSKLSLGFVKTITINSNDNYDVIIGKNNNFNKQNKEFKDKYVKVVVEDPYYNRDIILKVTKKQKGVYIWETLEGQNMYVGHSINLYNSISFYFMPSILNTKARRVVRHLNKHGFSDIKLTIYLMDIKSSLDQVVSLEQHFIDTLNPSLNVDLVASSSGYHEAMAQEIRKKLRKQRGTPVYIYEAESFTLLHIFDSKQYMYNTISIHHKTLHDCIDLGVLYLDSFFLSLDLLETENVYMLNLDQIKALVKTKRELHKLKHPASKAIFAEFKNDASKNLEFYSLNGLAKHLKGDRKVIREYIQGIKSGYYRGKWKFTYK","length":321,"molWeight":37538,"crc64":"D6DCE34DC3873A83","md5":"669900818A438186C4BBED31EBBA6785"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI00022AB580"}}]}