{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9FA03","uniProtkbId":"RL4_BRAPL","entryAudit":{"firstPublicDate":"2004-04-26","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2001-03-01","entryVersion":78,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01328"}],"value":"Large ribosomal subunit protein uL4"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"50S ribosomal protein L4"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01328"}],"value":"rplD"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01328"}],"value":"One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01328"}],"value":"Forms part of the polypeptide exit tunnel"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01328"}],"value":"Part of the 50S ribosomal subunit"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01328"}],"value":"Belongs to the universal ribosomal protein uL4 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Large ribosomal subunit protein uL4","featureId":"PRO_0000129192"},{"type":"Region","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"id":"KW-0689","category":"Molecular function","name":"Ribosomal protein"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0699","category":"Molecular function","name":"rRNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-FKSA62TEO46U0","citationType":"submission","authors":["Rayment S.J.","Livesley M.A."],"title":"A gene cluster of ribosomal proteins in Brachyspira pilosicoli.","publicationDate":"DEC-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 51139 / P43/6/78","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF114845","properties":[{"key":"ProteinId","value":"AAG27265.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_013243969.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CALHJJ010000004.1"}]},{"database":"AlphaFoldDB","id":"Q9FA03","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9FA03","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"56439590","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAGMFDC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9803201at2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005840","properties":[{"key":"GoTerm","value":"C:ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019843","properties":[{"key":"GoTerm","value":"F:rRNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003735","properties":[{"key":"GoTerm","value":"F:structural constituent of ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006412","properties":[{"key":"GoTerm","value":"P:translation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"3.40.1370.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01328_B","properties":[{"key":"EntryName","value":"Ribosomal_uL4_B"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002136","properties":[{"key":"EntryName","value":"Ribosomal_uL4"}]},{"database":"InterPro","id":"IPR013005","properties":[{"key":"EntryName","value":"Ribosomal_uL4-like"}]},{"database":"InterPro","id":"IPR023574","properties":[{"key":"EntryName","value":"Ribosomal_uL4_dom_sf"}]},{"database":"NCBIfam","id":"TIGR03953","properties":[{"key":"EntryName","value":"rplD_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10746","properties":[{"key":"EntryName","value":"50S RIBOSOMAL PROTEIN L4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10746:SF6","properties":[{"key":"EntryName","value":"LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00573","properties":[{"key":"EntryName","value":"Ribosomal_L4"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52166","properties":[{"key":"EntryName","value":"Ribosomal protein L4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEVVILNENGDSVGNLEVVDEIFKSEVNNNLLYEAIKNELANRRQGTHSTKTRAEVSGGGKKPWRQKGTGRARAGSTRSPIWVGGGKTHTPKPRDYSYRLPKKMKRKALLSVLSLKYGNNVLKVFEDFTFDAPKTKRMASFISKVKEPNSRKVAFVVGKDESLGDNYNKLLLSLRNIKDLKLVNADSMSIHPLYYADEVYFTKTALSKLNARIKG","length":215,"molWeight":24137,"crc64":"3D9FC3077098F3E1","md5":"1467E81EC6BB0E37D6051B4B05DE1E4C"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1},"uniParcId":"UPI00000B3882"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9FA05","uniProtkbId":"RS10_BRAPL","entryAudit":{"firstPublicDate":"2001-12-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2001-03-01","entryVersion":82,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00508"}],"value":"Small ribosomal subunit protein uS10"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"30S ribosomal protein S10"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00508"}],"value":"rpsJ"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00508"}],"value":"Involved in the binding of tRNA to the ribosomes"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00508"}],"value":"Part of the 30S ribosomal subunit"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_00508"}],"value":"Belongs to the universal ribosomal protein uS10 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Small ribosomal subunit protein uS10","featureId":"PRO_0000146506"}],"keywords":[{"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"id":"KW-0689","category":"Molecular function","name":"Ribosomal protein"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-FKSA62TEO46U0","citationType":"submission","authors":["Rayment S.J.","Livesley M.A."],"title":"A gene cluster of ribosomal proteins in Brachyspira pilosicoli.","publicationDate":"DEC-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 51139 / P43/6/78","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF114845","properties":[{"key":"ProteinId","value":"AAG27263.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_013243971.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CALHJJ010000004.1"}]},{"database":"AlphaFoldDB","id":"Q9FA05","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9FA05","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"56439592","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ACDHAML","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9804464at2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005840","properties":[{"key":"GoTerm","value":"C:ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003735","properties":[{"key":"GoTerm","value":"F:structural constituent of ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000049","properties":[{"key":"GoTerm","value":"F:tRNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006412","properties":[{"key":"GoTerm","value":"P:translation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"FunFam","id":"3.30.70.600:FF:000003","properties":[{"key":"EntryName","value":"30S ribosomal protein S10"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.600","properties":[{"key":"EntryName","value":"Ribosomal protein S10 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00508","properties":[{"key":"EntryName","value":"Ribosomal_uS10"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001848","properties":[{"key":"EntryName","value":"Ribosomal_uS10"}]},{"database":"InterPro","id":"IPR018268","properties":[{"key":"EntryName","value":"Ribosomal_uS10_CS"}]},{"database":"InterPro","id":"IPR027486","properties":[{"key":"EntryName","value":"Ribosomal_uS10_dom"}]},{"database":"InterPro","id":"IPR036838","properties":[{"key":"EntryName","value":"Ribosomal_uS10_dom_sf"}]},{"database":"NCBIfam","id":"NF001861","properties":[{"key":"EntryName","value":"rpsJ"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01049","properties":[{"key":"EntryName","value":"rpsJ_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11700","properties":[{"key":"EntryName","value":"30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00338","properties":[{"key":"EntryName","value":"Ribosomal_S10"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00971","properties":[{"key":"EntryName","value":"RIBOSOMALS10"}]},{"database":"SMART","id":"SM01403","properties":[{"key":"EntryName","value":"Ribosomal_S10"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54999","properties":[{"key":"EntryName","value":"Ribosomal protein S10"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00361","properties":[{"key":"EntryName","value":"RIBOSOMAL_S10"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKEQKIRVKLKAFDIELIDQSAQSIVASVKKTGARVSGPIPLPTSIRKVTVIRSPHVNIKSREQFEMRVYKRLIDIFDVTPQTTESLKKLALPAGVDVQLK","length":101,"molWeight":11368,"crc64":"B4261DC69F2A8F53","md5":"E5D2B90EE3680D66A3CEDB4C5CBEAFA5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI0000134B98"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9FA04","uniProtkbId":"RL3_BRAPL","entryAudit":{"firstPublicDate":"2004-02-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2001-03-01","entryVersion":72,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01325"}],"value":"Large ribosomal subunit protein uL3"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"50S ribosomal protein L3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01325"}],"value":"rplC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01325"}],"value":"One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01325"}],"value":"Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01325"}],"value":"Belongs to the universal ribosomal protein uL3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Large ribosomal subunit protein uL3","featureId":"PRO_0000077074"}],"keywords":[{"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"id":"KW-0689","category":"Molecular function","name":"Ribosomal protein"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0699","category":"Molecular function","name":"rRNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-FKSA62TEO46U0","citationType":"submission","authors":["Rayment S.J.","Livesley M.A."],"title":"A gene cluster of ribosomal proteins in Brachyspira pilosicoli.","publicationDate":"DEC-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 51139 / P43/6/78","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF114845","properties":[{"key":"ProteinId","value":"AAG27264.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_013243970.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CALHJJ010000004.1"}]},{"database":"AlphaFoldDB","id":"Q9FA04","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9FA04","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"56439591","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAHGSMM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9806135at2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0022625","properties":[{"key":"GoTerm","value":"C:cytosolic large ribosomal subunit"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019843","properties":[{"key":"GoTerm","value":"F:rRNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003735","properties":[{"key":"GoTerm","value":"F:structural constituent of ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006412","properties":[{"key":"GoTerm","value":"P:translation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"FunFam","id":"2.40.30.10:FF:000004","properties":[{"key":"EntryName","value":"50S ribosomal protein L3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.810:FF:000001","properties":[{"key":"EntryName","value":"50S ribosomal protein L3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.810","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.30.10","properties":[{"key":"EntryName","value":"Translation factors"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01325_B","properties":[{"key":"EntryName","value":"Ribosomal_uL3_B"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000597","properties":[{"key":"EntryName","value":"Ribosomal_uL3"}]},{"database":"InterPro","id":"IPR019927","properties":[{"key":"EntryName","value":"Ribosomal_uL3_bact_org"}]},{"database":"InterPro","id":"IPR019926","properties":[{"key":"EntryName","value":"Ribosomal_uL3_CS"}]},{"database":"InterPro","id":"IPR009000","properties":[{"key":"EntryName","value":"Transl_B-barrel_sf"}]},{"database":"NCBIfam","id":"TIGR03625","properties":[{"key":"EntryName","value":"L3_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11229","properties":[{"key":"EntryName","value":"50S RIBOSOMAL PROTEIN L3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11229:SF16","properties":[{"key":"EntryName","value":"LARGE RIBOSOMAL SUBUNIT PROTEIN UL3C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00297","properties":[{"key":"EntryName","value":"Ribosomal_L3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50447","properties":[{"key":"EntryName","value":"Translation proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00474","properties":[{"key":"EntryName","value":"RIBOSOMAL_L3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVGIIGRKLGMTTVFDETGNAIAVTVVEAGPCTVMQVRDNEKDGYNAIQLGYGAVKEKHLKKPQIGQFKKANLEPKKYLKEFRLDDSSAYTVGQELKVDIFQAGDFIDVSSLSKGRGFAGVMKRHNYDGGPMSHGSNFRRRAGSIGCNSYPARVWKGKGMPGHMGNTLTTIQNLKVVEIRPEDNLIMIKGSIPGAINGIVKITQAAKKKNKKKNSMTK","length":218,"molWeight":23832,"crc64":"A4AAFF1FFBF435E8","md5":"CE733F0E5940B4A13CF0EB51A485D86E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI00000B0ECB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0M3R8B1","uniProtkbId":"A0A0M3R8B1_BRAPL","entryAudit":{"firstPublicDate":"2015-12-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-12-09","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79290.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5048876789"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79290.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79290.1"}],"value":"V1 D 1","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79290.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR182168","properties":[{"key":"ProteinId","value":"ALC79290.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864098.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049757.1"}]},{"database":"AlphaFoldDB","id":"A0A0M3R8B1","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003632","properties":[{"key":"CARD short name","value":"OXA-475"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ALC79290","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSENMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKEGLKALNLLK","length":269,"molWeight":30899,"crc64":"7A912452F7D34227","md5":"B8594017CF1E6CF4CE11133A6F6EA86D"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0006BC7539"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0M3R8B2","uniProtkbId":"A0A0M3R8B2_BRAPL","entryAudit":{"firstPublicDate":"2015-12-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-12-09","entryVersion":26,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79294.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WIH94173.1"}],"value":"NEH99_07710"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5048416454"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79294.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79294.1"}],"value":"HRM 4B","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79294.1"}]},{"referenceNumber":2,"citation":{"id":"CI-30QAGN460U6DR","citationType":"submission","authors":["Schmitt S.","Arnold M.","Rossano A.","Perreten V."],"title":"Brachyspira pilosicoli from pigs in Switzerland.","publicationDate":"JUN-2022","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WIH94173.1"}],"value":"MEI4028","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WIH94173.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR182172","properties":[{"key":"ProteinId","value":"ALC79294.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP098754","properties":[{"key":"ProteinId","value":"WIH94173.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864102.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049761.1"}]},{"database":"AlphaFoldDB","id":"A0A0M3R8B2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0M3R8B2","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003636","properties":[{"key":"CARD short name","value":"OXA-479"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ALC79294","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQIKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":30942,"crc64":"844837F97461D9A4","md5":"FDAD53B76CC4A8424A64C14B8A3DDDB0"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0006BC1F6F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0M4FC81","uniProtkbId":"A0A0M4FC81_BRAPL","entryAudit":{"firstPublicDate":"2015-12-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-12-09","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79292.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5050188882"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79292.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79292.1"}],"value":"IMR 49","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79292.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR182170","properties":[{"key":"ProteinId","value":"ALC79292.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864100.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049759.1"}]},{"database":"AlphaFoldDB","id":"A0A0M4FC81","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003634","properties":[{"key":"CARD short name","value":"OXA-477"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ALC79292","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNVFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYIGEKVFLEFWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKNIGDSVDTFWLEGPLEISAMEQVELLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":31002,"crc64":"75810C41DD5FE80B","md5":"42D54797B641B7293F367591691E8229"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0006BD5441"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0M4FFA2","uniProtkbId":"A0A0M4FFA2_BRAPL","entryAudit":{"firstPublicDate":"2015-12-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-12-09","entryVersion":26,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79285.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5049040658"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79285.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79285.1"}],"value":"9803","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79285.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR182163","properties":[{"key":"ProteinId","value":"ALC79285.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864093.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049752.1"}]},{"database":"AlphaFoldDB","id":"A0A0M4FFA2","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003626","properties":[{"key":"CARD short name","value":"OXA-470"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ALC79285","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQIKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIEKESLKALNLLK","length":269,"molWeight":30972,"crc64":"844837EEEB61D9A4","md5":"E8968F51A4D08C7850396757EF96868C"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0006BCC960"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0M4FLF6","uniProtkbId":"A0A0M4FLF6_BRAPL","entryAudit":{"firstPublicDate":"2015-12-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-12-09","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79291.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5050846540"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79291.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79291.1"}],"value":"24072-93A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79291.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR182169","properties":[{"key":"ProteinId","value":"ALC79291.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864099.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049758.1"}]},{"database":"AlphaFoldDB","id":"A0A0M4FLF6","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003633","properties":[{"key":"CARD short name","value":"OXA-476"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ALC79291","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDNVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSENMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":30956,"crc64":"CBD53952FE411F91","md5":"0E30C387DEAA782ADA7BC2C4CA83EEC7"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0006BD3762"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0M4FM57","uniProtkbId":"A0A0M4FM57_BRAPL","entryAudit":{"firstPublicDate":"2015-12-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-12-09","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79289.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5048876599"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79289.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79289.1"}],"value":"GP 14","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79289.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR182167","properties":[{"key":"ProteinId","value":"ALC79289.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864097.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049756.1"}]},{"database":"AlphaFoldDB","id":"A0A0M4FM57","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003631","properties":[{"key":"CARD short name","value":"OXA-474"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ALC79289","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNVFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLEFWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":30975,"crc64":"987CEE397C365079","md5":"FE3F1FBEEE38C4CCE15309A6CFFDCBFD"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0006BCAD7C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0M4FSZ5","uniProtkbId":"A0A0M4FSZ5_BRAPL","entryAudit":{"firstPublicDate":"2015-12-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-12-09","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79293.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5049696276"},{"type":"Domain","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79293.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79293.1"}],"value":"H21","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79293.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR182171","properties":[{"key":"ProteinId","value":"ALC79293.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864101.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049760.1"}]},{"database":"AlphaFoldDB","id":"A0A0M4FSZ5","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003635","properties":[{"key":"CARD short name","value":"OXA-478"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ALC79293","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAELRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNSRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFGIEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLVDSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":30786,"crc64":"C464BC1CCD2691FE","md5":"BF6D4FE56600DF5E7D8B79B932413B0F"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0006BDD666"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0M4G476","uniProtkbId":"A0A0M4G476_BRAPL","entryAudit":{"firstPublicDate":"2015-12-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-12-09","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79288.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5048876568"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79288.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79288.1"}],"value":"HRM 7","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79288.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR182166","properties":[{"key":"ProteinId","value":"ALC79288.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864096.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049755.1"}]},{"database":"AlphaFoldDB","id":"A0A0M4G476","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003629","properties":[{"key":"CARD short name","value":"OXA-473"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ALC79288","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLEFWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAISDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":31003,"crc64":"D3B08982FB669F53","md5":"2AC0C09FCBE05ACB27FF99A15A4496E8"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0006BC7B15"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0M5JCV8","uniProtkbId":"A0A0M5JCV8_BRAPL","entryAudit":{"firstPublicDate":"2015-12-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2015-12-09","entryVersion":26,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79287.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5050189729"},{"type":"Domain","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79287.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79287.1"}],"value":"OF15","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79287.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR182165","properties":[{"key":"ProteinId","value":"ALC79287.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864095.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049754.1"}]},{"database":"AlphaFoldDB","id":"A0A0M5JCV8","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003628","properties":[{"key":"CARD short name","value":"OXA-472"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ALC79287","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAELRFYQASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQIKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":268,"molWeight":30829,"crc64":"7DB25E9DE33E8CFE","md5":"7538E2F24E0BBA36456A7AF0978C8736"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0006BCEC63"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A9Q1Z3","uniProtkbId":"A9Q1Z3_BRAPL","entryAudit":{"firstPublicDate":"2008-02-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-02-05","entryVersion":51,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12712.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12712.1"}],"value":"Alp"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12712.1"}],"value":"alp"}}],"comments":[{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"value":"Binds 1 Mg(2+) ion."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"value":"Binds 2 Zn(2+) ions."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003946"}],"value":"Belongs to the alkaline phosphatase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5052165328"},{"type":"Active site","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Phosphoserine intermediate","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-1"}]},{"type":"Binding site","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Non-terminal residue","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12712.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601952-2"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"18048921","citationType":"journal article","authors":["Rasback T.","Johansson K.E.","Jansson D.S.","Fellstrom C.","Alikhani M.Y.","La T.","Dunn D.S.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"18048921"},{"database":"DOI","id":"10.1099/mic.0.2007/008540-0"}],"title":"Development of a multilocus sequence typing scheme for intestinal spirochaetes within the genus Brachyspira.","publicationDate":"2007","journal":"Microbiology","firstPage":"4074","lastPage":"4087","volume":"153"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12712.1"}],"value":"95/1000","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12712.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF488211","properties":[{"key":"ProteinId","value":"ABS12712.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A9Q1Z3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A9Q1Z3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004035","properties":[{"key":"GoTerm","value":"F:alkaline phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd16012","properties":[{"key":"EntryName","value":"ALP"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.60.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.720.10","properties":[{"key":"EntryName","value":"Alkaline Phosphatase, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001952","properties":[{"key":"EntryName","value":"Alkaline_phosphatase"}]},{"database":"InterPro","id":"IPR017850","properties":[{"key":"EntryName","value":"Alkaline_phosphatase_core_sf"}]},{"database":"PANTHER","id":"PTHR11596","properties":[{"key":"EntryName","value":"ALKALINE PHOSPHATASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11596:SF5","properties":[{"key":"EntryName","value":"ALKALINE PHOSPHATASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00245","properties":[{"key":"EntryName","value":"Alk_phosphatase"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00113","properties":[{"key":"EntryName","value":"ALKPHPHTASE"}]},{"database":"SMART","id":"SM00098","properties":[{"key":"EntryName","value":"alkPPc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53649","properties":[{"key":"EntryName","value":"Alkaline phosphatase-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIQLLPILLLSAFFIGCGQQPYTNLENTPKAKNVIVLIADGQSSDVITYSRWFKGGDSLAIDEMLSGAVRTHNADSPIADSAPAGTALATGYKSSYQQFIGILPDEAILPNSSIPTEARAPIANVLEAAQLIGKSTGVISTSEIMHATPAAFSAHDITRKDYDDLSEQQVFQDIDVILGGGYKFFTKEARKDGKDLISEITNLGYSLIRTSDELDSFRGDKVVGLFADADLAYEIDREETTQPSLAQMTSKAIDILSKNDKGFFLIVEASKVDWAAHANDPVGLVSDTLAYVDAVKAALDFAKKDNNTMVIAVTDHGNSGFTMGNYDTSSDYHKRTLESFIEPVKKASRSAEYVARKIEAGEDIKTAMQKYYAIDDMTEEEVNSLRGKTGDDLHYAIGPILAKRAYLGFSTHGHTGEDVPLYTYLPNNKRIIGLIDNTDIAKNIASAMEINLDEATKKLFMSEDELKKAGVELTSDGNILTMHIGDKTAQIMKNRNIIIVNGEKKTLDGVVVYNESKWYFPSQVLDILK","length":529,"molWeight":57875,"crc64":"B535AAA97822B790","md5":"3767804AD052FC74394E8EEAD08B1C8A"},"extraAttributes":{"countByCommentType":{"COFACTOR":2,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Active site":1,"Binding site":10,"Non-terminal residue":1},"uniParcId":"UPI0001615034"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A9Q1Z5","uniProtkbId":"A9Q1Z5_BRAPL","entryAudit":{"firstPublicDate":"2008-02-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-02-05","entryVersion":69,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12714.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12714.1"}],"value":"Gdh"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12714.1"}],"value":"gdh"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15133"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"1.4.1.3","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10011"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11612"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.4.1.3","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10011"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011643"}],"value":"Homohexamer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006382"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004417"}],"value":"Belongs to the Glu/Leu/Phe/Val dehydrogenases family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00839"}]},{"type":"Active site","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10011"}]},{"type":"Active site","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-1"}]},{"type":"Binding site","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-2"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-2"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-2"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-2"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-2"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-2"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-2"}],"ligand":{"name":"substrate"}},{"type":"Site","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Important for catalysis","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-3"}]},{"type":"Non-terminal residue","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12714.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-2"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000185-2"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004417"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"18048921","citationType":"journal article","authors":["Rasback T.","Johansson K.E.","Jansson D.S.","Fellstrom C.","Alikhani M.Y.","La T.","Dunn D.S.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"18048921"},{"database":"DOI","id":"10.1099/mic.0.2007/008540-0"}],"title":"Development of a multilocus sequence typing scheme for intestinal spirochaetes within the genus Brachyspira.","publicationDate":"2007","journal":"Microbiology","firstPage":"4074","lastPage":"4087","volume":"153"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12714.1"}],"value":"95/1000","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12714.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF488213","properties":[{"key":"ProteinId","value":"ABS12714.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_013244251.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CALXQO010000001.1"}]},{"database":"AlphaFoldDB","id":"A9Q1Z5","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"56439877","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004354","properties":[{"key":"GoTerm","value":"F:L-glutamate dehydrogenase (NADP+) activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006520","properties":[{"key":"GoTerm","value":"P:amino acid metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd05313","properties":[{"key":"EntryName","value":"NAD_bind_2_Glu_DH"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.285.10:FF:000001","properties":[{"key":"EntryName","value":"Glutamate dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.10860:FF:000002","properties":[{"key":"EntryName","value":"Glutamate dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000030","properties":[{"key":"EntryName","value":"Glutamate dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.285.10","properties":[{"key":"EntryName","value":"Glutamate Dehydrogenase, chain A, domain 3"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.10860","properties":[{"key":"EntryName","value":"Leucine Dehydrogenase, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR046346","properties":[{"key":"EntryName","value":"Aminoacid_DH-like_N_sf"}]},{"database":"InterPro","id":"IPR006095","properties":[{"key":"EntryName","value":"Glu/Leu/Phe/Val/Trp_DH"}]},{"database":"InterPro","id":"IPR006096","properties":[{"key":"EntryName","value":"Glu/Leu/Phe/Val/Trp_DH_C"}]},{"database":"InterPro","id":"IPR006097","properties":[{"key":"EntryName","value":"Glu/Leu/Phe/Val/Trp_DH_dimer"}]},{"database":"InterPro","id":"IPR033524","properties":[{"key":"EntryName","value":"Glu/Leu/Phe/Val_DH_AS"}]},{"database":"InterPro","id":"IPR014362","properties":[{"key":"EntryName","value":"Glu_DH"}]},{"database":"InterPro","id":"IPR050724","properties":[{"key":"EntryName","value":"Glu_Leu_Phe_Val_DH"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR033922","properties":[{"key":"EntryName","value":"NAD_bind_Glu_DH"}]},{"database":"NCBIfam","id":"NF006929","properties":[{"key":"EntryName","value":"gdhA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43571","properties":[{"key":"EntryName","value":"NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43571:SF1","properties":[{"key":"EntryName","value":"NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00208","properties":[{"key":"EntryName","value":"ELFV_dehydrog"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02812","properties":[{"key":"EntryName","value":"ELFV_dehydrog_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000185","properties":[{"key":"EntryName","value":"Glu_DH"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00082","properties":[{"key":"EntryName","value":"GLFDHDRGNASE"}]},{"database":"SMART","id":"SM00839","properties":[{"key":"EntryName","value":"ELFV_dehydrog"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53223","properties":[{"key":"EntryName","value":"Aminoacid dehydrogenase-like, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00074","properties":[{"key":"EntryName","value":"GLFV_DEHYDROGENASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSRVKESIESIYSSIVQKNAGEKEFHQAVKEMLSTLEVVLEKHPEYIEKKVIERICEPERQIIFRVPWMDDKGEIHINRGFRVQFSSVMGPYKGGLRFHPSVYLGIIKFLSFEQIFKNALTGLSIGGGKGGSDFDPKGKSDNEVMRFCQSFMTELHRHIGADIDVPAGDIGVGAREIGYLFGQYKRLSGRYEAGVLTGKGLDYGGSLVRKEATGYGLVYFTELMLKTRNESFEGKKVIVSGSGNVAIYAMEKASQLGAKVIACSDSNGVLYDENGINLDTVKRLKEVERKRIKEYADIHKSAKYQENGCIWDIACDVALPCATQNEINADNAKTLVKNGCKCVAEGANMPATPEAIDVFLNANILYAPGKATNAGGVATSALEMQQNASRDSWDFEYTDGKLKNIMTNIHNTCYTTAEEYGFKGNYLKGANIAGFVKVAETMIPFGLI","length":449,"molWeight":49506,"crc64":"5321603E21487477","md5":"B34503E6C61567F58C92D5EC1058B4D9"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Active site":2,"Binding site":7,"Site":1,"Non-terminal residue":1},"uniParcId":"UPI0001615036"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A9Q1Z6","uniProtkbId":"A9Q1Z6_BRAPL","entryAudit":{"firstPublicDate":"2008-02-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-02-05","entryVersion":82,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12715.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012099"}],"value":"glycerol kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012099"}],"value":"2.7.1.30"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043149"}],"value":"ATP:glycerol 3-phosphotransferase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12715.1"}],"value":"glpK"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21644"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17754"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:57597"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.30","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052101"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005190"}],"value":"Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009156"}],"value":"Belongs to the FGGY kinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Carbohydrate kinase FGGY N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00370"}]},{"type":"Domain","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"Carbohydrate kinase FGGY C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02782"}]},{"type":"Non-terminal residue","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12715.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022798"}],"id":"KW-0319","category":"Biological process","name":"Glycerol metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"18048921","citationType":"journal article","authors":["Rasback T.","Johansson K.E.","Jansson D.S.","Fellstrom C.","Alikhani M.Y.","La T.","Dunn D.S.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"18048921"},{"database":"DOI","id":"10.1099/mic.0.2007/008540-0"}],"title":"Development of a multilocus sequence typing scheme for intestinal spirochaetes within the genus Brachyspira.","publicationDate":"2007","journal":"Microbiology","firstPage":"4074","lastPage":"4087","volume":"153"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12715.1"}],"value":"95/1000","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS12715.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF488214","properties":[{"key":"ProteinId","value":"ABS12715.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_013243752.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JAWLPP010000001.1"}]},{"database":"AlphaFoldDB","id":"A9Q1Z6","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"56439368","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004370","properties":[{"key":"GoTerm","value":"F:glycerol kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0019563","properties":[{"key":"GoTerm","value":"P:glycerol catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006072","properties":[{"key":"GoTerm","value":"P:glycerol-3-phosphate metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd07786","properties":[{"key":"EntryName","value":"FGGY_EcGK_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000007","properties":[{"key":"EntryName","value":"Glycerol kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.420.40:FF:000008","properties":[{"key":"EntryName","value":"Glycerol kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.420.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"HAMAP","id":"MF_00186","properties":[{"key":"EntryName","value":"Glycerol_kin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043129","properties":[{"key":"EntryName","value":"ATPase_NBD"}]},{"database":"InterPro","id":"IPR000577","properties":[{"key":"EntryName","value":"Carb_kinase_FGGY"}]},{"database":"InterPro","id":"IPR018483","properties":[{"key":"EntryName","value":"Carb_kinase_FGGY_CS"}]},{"database":"InterPro","id":"IPR018485","properties":[{"key":"EntryName","value":"FGGY_C"}]},{"database":"InterPro","id":"IPR018484","properties":[{"key":"EntryName","value":"FGGY_N"}]},{"database":"InterPro","id":"IPR005999","properties":[{"key":"EntryName","value":"Glycerol_kin"}]},{"database":"NCBIfam","id":"NF000756","properties":[{"key":"EntryName","value":"glpK"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01311","properties":[{"key":"EntryName","value":"glycerol_kin"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10196:SF69","properties":[{"key":"EntryName","value":"GLYCEROL KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10196","properties":[{"key":"EntryName","value":"SUGAR KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02782","properties":[{"key":"EntryName","value":"FGGY_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00370","properties":[{"key":"EntryName","value":"FGGY_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000538","properties":[{"key":"EntryName","value":"GlpK"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53067","properties":[{"key":"EntryName","value":"Actin-like ATPase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00933","properties":[{"key":"EntryName","value":"FGGY_KINASES_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKYVVAIDQGTTSSRAIVFDYEQNMVSVAQKEFTQIYPHEGWVEHNASEIWATQFGVLQEAIQIAGVKPEEIAAIGITNQRETTVVWDKNTGEPIYNAIVWQCRRTAPICDELKKKGLDTYIRENTGLVVDAYFSGTKIKWILDNVPGAREKANKGELLFGTIDTWLVWKLTGGKVHVTDYTNASRTMIYNIKDLKWDENILRELDIPISMLPEVKDSSCVYGYANINGKEVPIAGIAGDQQSALFGQAGFNKGDTKNTYGTGSFILMNIGENFILSKNGLITTIGIGYKGKIEYALEGSVFIAGAVIQWVRDELRLLHDAKDTEYFATKVKDTNGVYLVPAFVGLGAPYWDMYARGCLVGITRGVNRSHIIRAAEEAIAYQSKDVIDAMVADSKVKLSSLKVDGGACRDNFLMQFQADIIHTKVLRPQITETTALGAAYLAGLAVGFWKDKDEISNKWKLEREFTPSLSEEESNKKYMGWKKAVERAKGWAL","length":494,"molWeight":55012,"crc64":"3E2C5D419369F90D","md5":"76156FEB1005F7874CD1A14C29FFB5B3"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Non-terminal residue":1},"uniParcId":"UPI0001615037"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B4XT35","uniProtkbId":"B4XT35_BRAPL","entryAudit":{"firstPublicDate":"2008-09-23","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-09-23","entryVersion":46,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76134.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76134.1"}],"value":"OXA-136"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5048535229"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"18719182","citationType":"journal article","authors":["Mortimer-Jones S.M.","Phillips N.D.","La T.","Naresh R.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"18719182"},{"database":"DOI","id":"10.1099/jmm.0.2008/001552-0"}],"title":"Penicillin resistance in the intestinal spirochaete Brachyspira pilosicoli associated with OXA-136 and OXA-137, two new variants of the class D beta-lactamase OXA-63.","publicationDate":"2008","journal":"J. Med. Microbiol.","firstPage":"1122","lastPage":"1128","volume":"57"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76135.1"}],"value":"95/1000","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76136.1"}],"value":"Cof 10","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76134.1"}],"value":"Wes B","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76134.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU086830","properties":[{"key":"ProteinId","value":"ABW76134.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EU086831","properties":[{"key":"ProteinId","value":"ABW76135.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EU086832","properties":[{"key":"ProteinId","value":"ABW76136.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_013244277.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP098749.1"}]},{"database":"AlphaFoldDB","id":"B4XT35","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B4XT35","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"56439903","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ag:ABW76134","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAGFWPK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":30928,"crc64":"65DB2452F7D9E227","md5":"0C511C22FB2974B6D195A9CC8379F826"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI00017BA75A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B4XT38","uniProtkbId":"B4XT38_BRAPL","entryAudit":{"firstPublicDate":"2008-09-23","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-09-23","entryVersion":47,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76137.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76137.1"}],"value":"OXA-136"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5048535230"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79286.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"18719182","citationType":"journal article","authors":["Mortimer-Jones S.M.","Phillips N.D.","La T.","Naresh R.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"18719182"},{"database":"DOI","id":"10.1099/jmm.0.2008/001552-0"}],"title":"Penicillin resistance in the intestinal spirochaete Brachyspira pilosicoli associated with OXA-136 and OXA-137, two new variants of the class D beta-lactamase OXA-63.","publicationDate":"2008","journal":"J. Med. Microbiol.","firstPage":"1122","lastPage":"1128","volume":"57"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76137.1"}],"value":"Gap 51.2","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76137.1"}]},{"referenceNumber":2,"citation":{"id":"26315325","citationType":"journal article","authors":["La T.","Neo E.","Phillips N.D.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"26315325"},{"database":"DOI","id":"10.1099/jmm.0.000162"}],"title":"Genes encoding ten newly designated OXA-63 group class D ?-lactamases identified in strains of the pathogenic intestinal spirochaete Brachyspira pilosicoli.","publicationDate":"2015","journal":"J. Med. Microbiol.","firstPage":"1425","lastPage":"1435","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79286.1"}],"value":"Gap 51.2","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALC79286.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU086833","properties":[{"key":"ProteinId","value":"ABW76137.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KR182164","properties":[{"key":"ProteinId","value":"ALC79286.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864094.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049753.1"}]},{"database":"AlphaFoldDB","id":"B4XT38","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B4XT38","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ag:ALC79286","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAISDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":30942,"crc64":"73A19882F7C15984","md5":"71CE9E0B87691F2CB03E377882A16624"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI00017BA75B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B4XT39","uniProtkbId":"B4XT39_BRAPL","entryAudit":{"firstPublicDate":"2008-09-23","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-09-23","entryVersion":44,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76138.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76138.1"}],"value":"OXA-137"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5048535231"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"18719182","citationType":"journal article","authors":["Mortimer-Jones S.M.","Phillips N.D.","La T.","Naresh R.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"18719182"},{"database":"DOI","id":"10.1099/jmm.0.2008/001552-0"}],"title":"Penicillin resistance in the intestinal spirochaete Brachyspira pilosicoli associated with OXA-136 and OXA-137, two new variants of the class D beta-lactamase OXA-63.","publicationDate":"2008","journal":"J. Med. Microbiol.","firstPage":"1122","lastPage":"1128","volume":"57"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76138.1"}],"value":"H/A1","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76139.1"}],"value":"H/A2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76140.1"}],"value":"H/A3","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABW76138.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU086834","properties":[{"key":"ProteinId","value":"ABW76138.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EU086835","properties":[{"key":"ProteinId","value":"ABW76139.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"EU086836","properties":[{"key":"ProteinId","value":"ABW76140.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_014932145.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049436.1"}]},{"database":"AlphaFoldDB","id":"B4XT39","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B4XT39","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ag:ABW76138","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILTSCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQIKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":30930,"crc64":"8443EEF97466F0A4","md5":"38B67BCB3869EBF8B4D13748559687BC"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI00017BA75C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"D2WXM7","uniProtkbId":"D2WXM7_BRAPL","entryAudit":{"firstPublicDate":"2010-03-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2010-03-02","entryVersion":40,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADB22524.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADB22524.1"}],"value":"Oligopeptide-binding protein 2"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004196"}],"value":"Cell envelope","id":"SL-0036"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005695"}],"value":"Belongs to the bacterial solute-binding protein 5 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051159533"},{"type":"Domain","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Solute-binding protein family 5","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00496"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"19959628","citationType":"journal article","authors":["Movahedi A.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"19959628"},{"database":"DOI","id":"10.1099/jmm.0.015842-0"}],"title":"Evaluation of recombinant Brachyspira pilosicoli oligopeptide-binding proteins as vaccine candidates in a mouse model of intestinal spirochaetosis.","publicationDate":"2009","journal":"J. Med. Microbiol.","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADB22524.1"}],"value":"95/1000","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADB22524.1"}]},{"referenceNumber":2,"citation":{"id":"CI-1ERIPRUR3IJIJ","citationType":"submission","authors":["La T.","Phillips N.D.","Hampson D.J."],"publicationDate":"AUG-2009","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADB22524.1"}],"value":"95/1000","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADB22524.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GQ478428","properties":[{"key":"ProteinId","value":"ADB22524.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"D2WXM7","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"56439363","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AADYAWF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"GO","id":"GO:0043190","properties":[{"key":"GoTerm","value":"C:ATP-binding cassette (ABC) transporter complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0030288","properties":[{"key":"GoTerm","value":"C:outer membrane-bounded periplasmic space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1904680","properties":[{"key":"GoTerm","value":"F:peptide transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0015833","properties":[{"key":"GoTerm","value":"P:peptide transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd08504","properties":[{"key":"EntryName","value":"PBP2_OppA"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.76.10:FF:000001","properties":[{"key":"EntryName","value":"Oligopeptide ABC transporter substrate-binding protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.105.10:FF:000001","properties":[{"key":"EntryName","value":"Oligopeptide ABC transporter, oligopeptide-binding protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.76.10","properties":[{"key":"EntryName","value":"Dipeptide-binding Protein, Domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.105.10","properties":[{"key":"EntryName","value":"Dipeptide-binding Protein, Domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.190.10","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like II"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR030678","properties":[{"key":"EntryName","value":"Peptide/Ni-bd"}]},{"database":"InterPro","id":"IPR039424","properties":[{"key":"EntryName","value":"SBP_5"}]},{"database":"InterPro","id":"IPR000914","properties":[{"key":"EntryName","value":"SBP_5_dom"}]},{"database":"PANTHER","id":"PTHR30290:SF79","properties":[{"key":"EntryName","value":"DIPEPTIDE-BINDING PROTEIN DPPE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30290","properties":[{"key":"EntryName","value":"PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00496","properties":[{"key":"EntryName","value":"SBP_bac_5"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF002741","properties":[{"key":"EntryName","value":"MppA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53850","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like II"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFKKIITAILLILLIISCSKKEIITNNEIVINLAPEPLTMDPTLNTDNLTMIYILHAFEGLTKKDANNKIIGGVAETWDINKEGNIYTFHLRTNAKWSDGKEVKAEDFVYTWRRAVDPKTANKYSYYFEVIKNAKEVISGEKTVEELGVKAIDDYTFEVELNSPTAYFLELAAYPPFYPVREDIINKYGDKWTLKPATYIGNGAFKMTERNFDKSIILERNTNYWNNENIKPNKLTFLLMEEPNTSLAGVLNNSIHFAKPFPRNDIESLKQKGIVHIVPVAASYYYRFNLNKEVLKDEKVRKAISLAIDRDYIVKSITRCGERPAGSLVPYGINDIDGDFRTKGGEYIISSNYQKNIEEAKKLLSQAGYENCRNFPVIDLLIATREFDINIADAVQSMLKENLNIDVRIVKHEWASYLQNMYDRNFDLAVYLWYADYNDPINFLNIFKSDAPNNYGSYSNKAFDDYIDIASTNKNNDIRMPALHSAENIFMNDNAIIPIYFYSEALLVSPKLKGVEYDSQGLYRFFNAYLE","length":531,"molWeight":61103,"crc64":"F5E2DC44F9DC824B","md5":"F37889E782939EAB315BDF94D2C026DF"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI0001C23D9C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G0ZGG5","uniProtkbId":"G0ZGG5_BRAPL","entryAudit":{"firstPublicDate":"2011-10-19","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-10-19","entryVersion":36,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADZ54048.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADZ54048.1"}],"value":"OXA-192"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5050834044"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"21812718","citationType":"journal article","authors":["Jansson D.S.","Pringle M."],"citationCrossReferences":[{"database":"PubMed","id":"21812718"},{"database":"DOI","id":"10.1080/03079457.2011.588197"}],"title":"Antimicrobial susceptibility of Brachyspira spp. isolated from commercial laying hens and free-living wild mallards.","publicationDate":"2011","journal":"Avian Pathol.","firstPage":"387","lastPage":"393","volume":"40"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADZ54048.1"}],"value":"AN3635/3/02","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADZ54048.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF273470","properties":[{"key":"ProteinId","value":"ADZ54048.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063861316.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049488.1"}]},{"database":"AlphaFoldDB","id":"G0ZGG5","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3001766","properties":[{"key":"CARD short name","value":"OXA-192"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:ADZ54048","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKTSNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLEKMKENIEKLDFGNKNIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTDNYTLHGKTGLADSENMTTEPIGWLVGWLEENNNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":269,"molWeight":30862,"crc64":"08847F453069F88A","md5":"CBB83D65FD1F9BDDB763F055BE2E2781"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI00021BBFBE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q50H31","uniProtkbId":"Q50H31_BRAPL","entryAudit":{"firstPublicDate":"2005-06-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2005-06-07","entryVersion":57,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAU88145.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"beta-lactamase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012865"}],"value":"3.5.2.6"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAU88145.1"}],"value":"oxa-63"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-lactam + H2O = a substituted beta-amino acid","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20401"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:35627"},{"database":"ChEBI","id":"CHEBI:140347"}],"ecNumber":"3.5.2.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001526"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007898"}],"value":"Belongs to the class-D beta-lactamase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"beta-lactamase","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5049032875"},{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Penicillin-binding protein transpeptidase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00905"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"18212108","citationType":"journal article","authors":["Meziane-Cherif D.","Lambert T.","Dupechez M.","Courvalin P.","Galimand M."],"citationCrossReferences":[{"database":"PubMed","id":"18212108"},{"database":"DOI","id":"10.1128/AAC.00684-07"}],"title":"Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.","publicationDate":"2008","journal":"Antimicrob. Agents Chemother.","firstPage":"1264","lastPage":"1268","volume":"52"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAU88145.1"}],"value":"BM4442","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAU88145.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY619003","properties":[{"key":"ProteinId","value":"AAU88145.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063864528.1","properties":[{"key":"NucleotideSequenceId","value":"NG_049803.1"}]},{"database":"AlphaFoldDB","id":"Q50H31","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q50H31","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q50H31","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1255145","properties":[{"key":"Description","value":"-"}]},{"database":"DrugCentral","id":"Q50H31","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3001764","properties":[{"key":"CARD short name","value":"OXA-63"},{"key":"Resistance mechanism identifier","value":"ARO:0001004"},{"key":"Resistance mechanism name","value":"antibiotic inactivation"}]},{"database":"KEGG","id":"ag:AAU88145","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.5.2.6","properties":[{"key":"OrganismId","value":"10264"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008800","properties":[{"key":"GoTerm","value":"F:beta-lactamase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008658","properties":[{"key":"GoTerm","value":"F:penicillin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071555","properties":[{"key":"GoTerm","value":"P:cell wall organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.710.10","properties":[{"key":"EntryName","value":"DD-peptidase/beta-lactamase superfamily"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050515","properties":[{"key":"EntryName","value":"Beta-lactam/transpept"}]},{"database":"InterPro","id":"IPR012338","properties":[{"key":"EntryName","value":"Beta-lactam/transpept-like"}]},{"database":"InterPro","id":"IPR001460","properties":[{"key":"EntryName","value":"PCN-bd_Tpept"}]},{"database":"NCBIfam","id":"NF012161","properties":[{"key":"EntryName","value":"bla_class_D_main"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF000429","properties":[{"key":"EntryName","value":"blaOXA-63_like"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627:SF6","properties":[{"key":"EntryName","value":"BETA-LACTAMASE YBXI-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30627","properties":[{"key":"EntryName","value":"PEPTIDOGLYCAN D,D-TRANSPEPTIDASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00905","properties":[{"key":"EntryName","value":"Transpeptidase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56601","properties":[{"key":"EntryName","value":"beta-lactamase/transpeptidase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKLMAKSFLESWAKDSNLRYAIKNSQVPAYKELARRIGIKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELQYPIEIQKAISDITITRANLHITLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK","length":268,"molWeight":30707,"crc64":"0A0F6FE476A59FD1","md5":"3EEA645676A85EC67DC2274F99C2BA70"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI000050C1EE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6VAN2","uniProtkbId":"Q6VAN2_BRAPL","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-07-05","entryVersion":80,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83492.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"NCBIfam","id":"TIGR03150"}],"value":"Beta-ketoacyl-ACP synthase II"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"NCBIfam","id":"TIGR03150"}],"value":"2.3.1.179"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83492.1"}],"value":"fabF"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22836"},{"database":"Rhea","id":"RHEA-COMP:9623"},{"database":"Rhea","id":"RHEA-COMP:9685"},{"database":"Rhea","id":"RHEA-COMP:9916"},{"database":"Rhea","id":"RHEA-COMP:14125"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:64479"},{"database":"ChEBI","id":"CHEBI:78449"},{"database":"ChEBI","id":"CHEBI:78776"},{"database":"ChEBI","id":"CHEBI:138651"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005194"}],"value":"Lipid metabolism; fatty acid biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008467"}],"value":"Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Beta-ketoacyl-ACP synthase II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"featureId":"PRO_5051166520"},{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Ketosynthase family 3 (KS3)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS52004"}]},{"type":"Active site","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}]},{"type":"Active site","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"For beta-ketoacyl synthase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000447-1"}]},{"type":"Lipidation","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Non-terminal residue","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83492.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023315"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023160"}],"id":"KW-0275","category":"Biological process","name":"Fatty acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022832"}],"id":"KW-0276","category":"Biological process","name":"Fatty acid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022516"}],"id":"KW-0444","category":"Biological process","name":"Lipid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"16701522","citationType":"journal article","authors":["Zuerner R.L.","Stanton T.B.","Minion F.C.","Li C.","Charon N.W.","Trott D.J.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"16701522"}],"title":"Genetic variation in Brachyspira: chromosomal rearrangements and sequence drift distinguish B. pilosicoli from B. hyodysenteriae.","publicationDate":"2004","journal":"Anaerobe","firstPage":"229","lastPage":"237","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83492.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY345132","properties":[{"key":"ProteinId","value":"AAQ83492.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q6VAN2","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00094","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0004315","properties":[{"key":"GoTerm","value":"F:3-oxoacyl-[acyl-carrier-protein] synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006633","properties":[{"key":"GoTerm","value":"P:fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00834","properties":[{"key":"EntryName","value":"KAS_I_II"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.47.10:FF:000018","properties":[{"key":"EntryName","value":"3-oxoacyl-[acyl-carrier-protein] synthase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.47.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017568","properties":[{"key":"EntryName","value":"3-oxoacyl-ACP_synth-2"}]},{"database":"InterPro","id":"IPR000794","properties":[{"key":"EntryName","value":"Beta-ketoacyl_synthase"}]},{"database":"InterPro","id":"IPR014031","properties":[{"key":"EntryName","value":"KAS_C"}]},{"database":"InterPro","id":"IPR014030","properties":[{"key":"EntryName","value":"KAS_N"}]},{"database":"InterPro","id":"IPR018201","properties":[{"key":"EntryName","value":"Ketoacyl_synth_AS"}]},{"database":"InterPro","id":"IPR020841","properties":[{"key":"EntryName","value":"PKS_Beta-ketoAc_synthase_dom"}]},{"database":"InterPro","id":"IPR016039","properties":[{"key":"EntryName","value":"Thiolase-like"}]},{"database":"NCBIfam","id":"TIGR03150","properties":[{"key":"EntryName","value":"fabF"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF005589","properties":[{"key":"EntryName","value":"PRK07314.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11712:SF336","properties":[{"key":"EntryName","value":"3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11712","properties":[{"key":"EntryName","value":"POLYKETIDE SYNTHASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00109","properties":[{"key":"EntryName","value":"ketoacyl-synt"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02801","properties":[{"key":"EntryName","value":"Ketoacyl-synt_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000447","properties":[{"key":"EntryName","value":"KAS_II"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00825","properties":[{"key":"EntryName","value":"PKS_KS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53901","properties":[{"key":"EntryName","value":"Thiolase-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00606","properties":[{"key":"EntryName","value":"KS3_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52004","properties":[{"key":"EntryName","value":"KS3_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSERRVVITGLGIVSCLGNDVKTFWDNLLNGVSGIKPLSKYFDPEKEQLVTRIGGEVAALEGDYYSDKKMLRRLDPFITYGVYAAYHALKQAGIEPKTGFDPLRAGCVLGSGIGGITTLLNNHNVILADGPSRVSPFFVPMQIINMTPGLIAMEYGMNGPNYSTVTACASSNHSIGLGYKHIKDNEADIMIVGGSEATINPLTIAGFNNARALSTKNDEPTKASRPFDKGRDGFVIAEGAGILVLEEYEHAKKRNANILAEVSGYGFTCDANHITAPLEDGAMGARAMSLAIESAKISPDKIDYVNTHGTSTPVGDIAEIKAIKKALGEDHAKKIKVNSTKSMTGHALGAAGGIEAIATVMSIIDSKVHPTINVE","length":375,"molWeight":39853,"crc64":"F475458122B63686","md5":"8EFFB5A21E6DBE5970CD390B3EA98018"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Active site":2,"Lipidation":2,"Non-terminal residue":1},"uniParcId":"UPI00001D4429"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6VAN3","uniProtkbId":"Q6VAN3_BRAPL","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-07-05","entryVersion":116,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83491.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"},{"evidenceCode":"ECO:0000256","source":"NCBIfam","id":"TIGR00517"}],"value":"Acyl carrier protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"value":"ACP"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83491.1"}],"value":"hlyA"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"TXJ43432.1"}],"value":"acpP"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"TXJ43432.1"}],"value":"EPJ72_04120"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WIH94995.1"}],"value":"NEH99_00310"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003545"}],"value":"Carrier of the growing fatty acid chain in fatty acid biosynthesis"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"pantetheine 4'-phosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00258"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:47942"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003545"}],"value":"Lipid metabolism; fatty acid biosynthesis"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"value":"4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003545"}],"value":"4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"value":"Belongs to the acyl carrier protein (ACP) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Carrier","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50075"}]},{"type":"Modified residue","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00258"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023160"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"id":"KW-0275","category":"Biological process","name":"Fatty acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022832"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"id":"KW-0276","category":"Biological process","name":"Fatty acid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"id":"KW-0444","category":"Biological process","name":"Lipid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022450"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"id":"KW-0596","category":"PTM","name":"Phosphopantetheine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_01217"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"}],"references":[{"referenceNumber":1,"citation":{"id":"1405919","citationType":"journal article","authors":["Kamme C.","Lundgren K.","Prellner K."],"citationCrossReferences":[{"database":"PubMed","id":"1405919"}],"title":"[Penicillin V and not amoxicillin is the first choice preparation in acute otitis].","publicationDate":"1992","journal":"Lakartidningen","firstPage":"3149","lastPage":"3149","volume":"89"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"TXJ43432.1"}],"value":"PC5538III-hc","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"TXJ43432.1"}]},{"referenceNumber":2,"citation":{"id":"16701522","citationType":"journal article","authors":["Zuerner R.L.","Stanton T.B.","Minion F.C.","Li C.","Charon N.W.","Trott D.J.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"16701522"}],"title":"Genetic variation in Brachyspira: chromosomal rearrangements and sequence drift distinguish B. pilosicoli from B. hyodysenteriae.","publicationDate":"2004","journal":"Anaerobe","firstPage":"229","lastPage":"237","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83491.1"}]},{"referenceNumber":3,"citation":{"id":"CI-AH0RRSP6193O5","citationType":"submission","authors":["Thorell K."],"publicationDate":"JAN-2019","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"TXJ43432.1"}],"value":"PC5538III-hc","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"TXJ43432.1"}]},{"referenceNumber":4,"citation":{"id":"CI-30QAGN460U6DR","citationType":"submission","authors":["Schmitt S.","Arnold M.","Rossano A.","Perreten V."],"title":"Brachyspira pilosicoli from pigs in Switzerland.","publicationDate":"JUN-2022","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WIH94995.1"}],"value":"MEI4028","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WIH94995.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY345132","properties":[{"key":"ProteinId","value":"AAQ83491.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"SAXY01000029","properties":[{"key":"ProteinId","value":"TXJ43432.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP098754","properties":[{"key":"ProteinId","value":"WIH94995.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_013243488.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CALHJJ010000047.1"}]},{"database":"AlphaFoldDB","id":"Q6VAN3","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"56439112","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9804551at2","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00094","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000035","properties":[{"key":"GoTerm","value":"F:acyl binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000036","properties":[{"key":"GoTerm","value":"F:acyl carrier activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009245","properties":[{"key":"GoTerm","value":"P:lipid A biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.10.1200.10","properties":[{"key":"EntryName","value":"ACP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01217","properties":[{"key":"EntryName","value":"Acyl_carrier"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003231","properties":[{"key":"EntryName","value":"ACP"}]},{"database":"InterPro","id":"IPR036736","properties":[{"key":"EntryName","value":"ACP-like_sf"}]},{"database":"InterPro","id":"IPR009081","properties":[{"key":"EntryName","value":"PP-bd_ACP"}]},{"database":"InterPro","id":"IPR006162","properties":[{"key":"EntryName","value":"Ppantetheine_attach_site"}]},{"database":"NCBIfam","id":"TIGR00517","properties":[{"key":"EntryName","value":"acyl_carrier"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF002148","properties":[{"key":"EntryName","value":"PRK00982.1-2"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF002150","properties":[{"key":"EntryName","value":"PRK00982.1-4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR20863","properties":[{"key":"EntryName","value":"ACYL CARRIER PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR20863:SF76","properties":[{"key":"EntryName","value":"CARRIER DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00550","properties":[{"key":"EntryName","value":"PP-binding"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47336","properties":[{"key":"EntryName","value":"ACP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50075","properties":[{"key":"EntryName","value":"CARRIER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00012","properties":[{"key":"EntryName","value":"PHOSPHOPANTETHEINE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALIDEIKDVVANQLNISDKSKITDTASFVDDLNADSLDLVELIMELEKRYDIKIPQEEQEKIKNVADAAKYIEEHKK","length":78,"molWeight":8934,"crc64":"5F21E6FCCB72C715","md5":"E2DCDFD70D421D9E7134AE49D0AEBE27"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"PTM":2,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Modified residue":1},"uniParcId":"UPI00001D4428"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q6VAN4","uniProtkbId":"Q6VAN4_BRAPL","entryAudit":{"firstPublicDate":"2004-07-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2004-07-05","entryVersion":92,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83490.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012948"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"value":"3-oxoacyl-[acyl-carrier-protein] reductase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012948"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"value":"1.1.1.100"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83490.1"}],"value":"fabG"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WIH94994.1"}],"value":"NEH99_00305"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"value":"Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17397"},{"database":"Rhea","id":"RHEA-COMP:9916"},{"database":"Rhea","id":"RHEA-COMP:9945"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:78776"},{"database":"ChEBI","id":"CHEBI:78827"}],"ecNumber":"1.1.1.100","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005194"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"value":"Lipid metabolism; fatty acid biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006484"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"value":"Belongs to the short-chain dehydrogenases/reductases (SDR) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Ketoreductase","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00822"}]},{"type":"Active site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR611284-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10001"}]},{"type":"Binding site","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR611284-2"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}},{"type":"Binding site","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR611284-2"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}},{"type":"Binding site","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR611284-2"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}},{"type":"Binding site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR611284-2"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}},{"type":"Binding site","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR611284-2"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023160"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"id":"KW-0275","category":"Biological process","name":"Fatty acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022832"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"id":"KW-0276","category":"Biological process","name":"Fatty acid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022516"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"id":"KW-0444","category":"Biological process","name":"Lipid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR611284-2"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366074"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"16701522","citationType":"journal article","authors":["Zuerner R.L.","Stanton T.B.","Minion F.C.","Li C.","Charon N.W.","Trott D.J.","Hampson D.J."],"citationCrossReferences":[{"database":"PubMed","id":"16701522"}],"title":"Genetic variation in Brachyspira: chromosomal rearrangements and sequence drift distinguish B. pilosicoli from B. hyodysenteriae.","publicationDate":"2004","journal":"Anaerobe","firstPage":"229","lastPage":"237","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAQ83490.1"}]},{"referenceNumber":2,"citation":{"id":"CI-30QAGN460U6DR","citationType":"submission","authors":["Schmitt S.","Arnold M.","Rossano A.","Perreten V."],"title":"Brachyspira pilosicoli from pigs in Switzerland.","publicationDate":"JUN-2022","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WIH94994.1"}],"value":"MEI4028","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WIH94994.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY345132","properties":[{"key":"ProteinId","value":"AAQ83490.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP098754","properties":[{"key":"ProteinId","value":"WIH94994.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_013243489.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CALXQO010000003.1"}]},{"database":"AlphaFoldDB","id":"Q6VAN4","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"56439113","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AAAWKIY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"UniPathway","id":"UPA00094","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0004316","properties":[{"key":"GoTerm","value":"F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0051287","properties":[{"key":"GoTerm","value":"F:NAD binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0030497","properties":[{"key":"GoTerm","value":"P:fatty acid elongation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd05333","properties":[{"key":"EntryName","value":"BKR_SDR_c"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000037","properties":[{"key":"EntryName","value":"3-oxoacyl-[acyl-carrier-protein] reductase FabG"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011284","properties":[{"key":"EntryName","value":"3oxo_ACP_reduc"}]},{"database":"InterPro","id":"IPR057326","properties":[{"key":"EntryName","value":"KR_dom"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR020904","properties":[{"key":"EntryName","value":"Sc_DH/Rdtase_CS"}]},{"database":"InterPro","id":"IPR050259","properties":[{"key":"EntryName","value":"SDR"}]},{"database":"InterPro","id":"IPR002347","properties":[{"key":"EntryName","value":"SDR_fam"}]},{"database":"NCBIfam","id":"TIGR01830","properties":[{"key":"EntryName","value":"3oxo_ACP_reduc"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF009466","properties":[{"key":"EntryName","value":"fabG"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF005559","properties":[{"key":"EntryName","value":"PRK07231.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42879","properties":[{"key":"EntryName","value":"3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42879:SF2","properties":[{"key":"EntryName","value":"3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13561","properties":[{"key":"EntryName","value":"adh_short_C2"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00081","properties":[{"key":"EntryName","value":"GDHRDH"}]},{"database":"PRINTS","id":"PR00080","properties":[{"key":"EntryName","value":"SDRFAMILY"}]},{"database":"SMART","id":"SM00822","properties":[{"key":"EntryName","value":"PKS_KR"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00061","properties":[{"key":"EntryName","value":"ADH_SHORT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDLNLKNKIALVTGGSRGIGKKIAEALANEGANVVVTATNINKAQEVADELKSKYNVETLALVHDVKSSESCKDVVAKTIEKFGSIDILVNNAGITRDMLVIQMDDSAWNDVIDTNLSGAFYTSREAAKSMLRARKGKIINISSVIGKMGNAGQVNYAAAKAGIIGITKSMAKEFAPRGICVNAIAPGFIQTDMTGVLAEDAVKKIMDITPLKKLGNAEDVANIVVFLASDLSNYITGEVIAVDGGMSM","length":249,"molWeight":26282,"crc64":"39F6A98151014903","md5":"4D054E2BCDB0BBE37EE3DA5AC4EE6D99"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Active site":1,"Binding site":5},"uniParcId":"UPI00001D4427"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9KJ94","uniProtkbId":"Q9KJ94_BRAPL","entryAudit":{"firstPublicDate":"2000-10-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2000-10-01","entryVersion":52,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Brachyspira pilosicoli","commonName":"Serpulina pilosicoli","taxonId":52584,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF97729.1"}],"lineage":["Bacteria","Pseudomonadati","Spirochaetota","Spirochaetia","Brachyspirales","Brachyspiraceae","Brachyspira"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034344"}],"value":"D-galactose/methyl-galactoside binding periplasmic protein MglB"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF97729.1"}],"value":"mglB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034323"}],"value":"The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004196"}],"value":"Cell envelope","id":"SL-0036"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007639"}],"value":"Belongs to the bacterial solute-binding protein 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"D-galactose/methyl-galactoside binding periplasmic protein MglB","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5049525813"},{"type":"Domain","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Periplasmic binding protein","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF13407"}]},{"type":"Lipidation","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"N-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]},{"type":"Lipidation","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"S-diacylglycerol cysteine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022764"}],"id":"KW-0574","category":"Cellular component","name":"Periplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00303"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022597"}],"id":"KW-0762","category":"Biological process","name":"Sugar transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"10899855","citationType":"journal article","authors":["Zhang P.","Cheng X.","Duhamel G.E."],"citationCrossReferences":[{"database":"PubMed","id":"10899855"},{"database":"DOI","id":"10.1128/IAI.68.8.4559-4565.2000"}],"title":"Cloning and DNA sequence analysis of an immunogenic glucose-galactose MglB lipoprotein homologue from Brachyspira pilosicoli, the agent of colonic spirochetosis.","publicationDate":"2000","journal":"Infect. Immun.","firstPage":"4559","lastPage":"4565","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF97729.1"}],"value":"SP16","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF97729.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF200741","properties":[{"key":"ProteinId","value":"AAF97729.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q9KJ94","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0030288","properties":[{"key":"GoTerm","value":"C:outer membrane-bounded periplasmic space"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030246","properties":[{"key":"GoTerm","value":"F:carbohydrate binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd01539","properties":[{"key":"EntryName","value":"PBP1_GGBP"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR050555","properties":[{"key":"EntryName","value":"Bact_Solute-Bind_Prot2"}]},{"database":"InterPro","id":"IPR044085","properties":[{"key":"EntryName","value":"MglB-like_PBP1"}]},{"database":"InterPro","id":"IPR028082","properties":[{"key":"EntryName","value":"Peripla_BP_I"}]},{"database":"InterPro","id":"IPR025997","properties":[{"key":"EntryName","value":"SBP_2_dom"}]},{"database":"PANTHER","id":"PTHR30036:SF2","properties":[{"key":"EntryName","value":"D-GALACTOSE_METHYL-GALACTOSIDE BINDING PERIPLASMIC PROTEIN MGLB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30036","properties":[{"key":"EntryName","value":"D-XYLOSE-BINDING PERIPLASMIC PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13407","properties":[{"key":"EntryName","value":"Peripla_BP_4"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53822","properties":[{"key":"EntryName","value":"Periplasmic binding protein-like I"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51257","properties":[{"key":"EntryName","value":"PROKAR_LIPOPROTEIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRKIFIISSMLIIATIFTVSCGGGTKDNAAASDANGPLIGVTIYRYDDNFMSFLRRNIETRISGKAQLLMNDSQNNQAQQNDQVDVMLNKNVNALAINLVDPQAAQTIIDKAKAKNIPVVFFNKQPSAEAMASYDKTWYVGTKPEESGDMQGKIVVDAWKADPTLDKNGDGIIQYVLIKGEPGHPDAEARTSHVTMYITNNGIKVEKLEELNANWDTARAKDIVDAWIQKYGDKIEFIFSNNDSMALGALQSIQALGYNTGDKAKYIPIVGVDAIPDMLNEIKKGTILGSVLNDPVGQSQALIDLSLNVAAGKDPLDGTTWTLDEVKAVRVPYVPITADNITIAEEAYK","length":349,"molWeight":38089,"crc64":"2DF544CF9986D836","md5":"5DB09211A2A7441ADCA55AB2A5E7AB53"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Lipidation":2},"uniParcId":"UPI00000B661B"}}]}