{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9LRU1","uniProtkbId":"E9LRU1_9CLOT","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":32,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77909.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Triosephosphate isomerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"5.3.1.1"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77909.1"}],"value":"tpi"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18585"},{"database":"ChEBI","id":"CHEBI:57642"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"5.3.1.1","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate biosynthesis; gluconeogenesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007422"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Belongs to the triosephosphate isomerase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77909.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77909.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0312","category":"Biological process","name":"Gluconeogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0324","category":"Biological process","name":"Glycolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"21182874","citationType":"journal article","authors":["Garofolo G.","Galante D.","Serrecchia L.","Buonavoglia D.","Fasanella A."],"citationCrossReferences":[{"database":"PubMed","id":"21182874"},{"database":"DOI","id":"10.1016/j.mimet.2010.12.017"}],"title":"Development of a real time PCR Taqman assay based on the TPI gene for simultaneous identification of Clostridium chauvoei and Clostridium septicum.","publicationDate":"2011","journal":"J. Microbiol. Methods","firstPage":"307","lastPage":"311","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77911.1"}],"value":"C1_1","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77912.1"}],"value":"C1_2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77913.1"}],"value":"C1_3","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77917.1"}],"value":"C2_5","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77920.1"}],"value":"C30_4","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77909.1"}],"value":"JGS433","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77910.1"}],"value":"JGS434","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77922.1"}],"value":"NCTC13023","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77909.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ123263","properties":[{"key":"ProteinId","value":"ADV77909.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123264","properties":[{"key":"ProteinId","value":"ADV77910.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123265","properties":[{"key":"ProteinId","value":"ADV77911.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123266","properties":[{"key":"ProteinId","value":"ADV77912.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123267","properties":[{"key":"ProteinId","value":"ADV77913.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123271","properties":[{"key":"ProteinId","value":"ADV77917.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123274","properties":[{"key":"ProteinId","value":"ADV77920.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123276","properties":[{"key":"ProteinId","value":"ADV77922.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9LRU1","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00109","properties":[{"key":"RectionId","value":"UER00189"}]},{"database":"UniPathway","id":"UPA00138","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004807","properties":[{"key":"GoTerm","value":"F:triose-phosphate isomerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006094","properties":[{"key":"GoTerm","value":"P:gluconeogenesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0046166","properties":[{"key":"GoTerm","value":"P:glyceraldehyde-3-phosphate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019563","properties":[{"key":"GoTerm","value":"P:glycerol catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006096","properties":[{"key":"GoTerm","value":"P:glycolytic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd00311","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR035990","properties":[{"key":"EntryName","value":"TIM_sf"}]},{"database":"InterPro","id":"IPR000652","properties":[{"key":"EntryName","value":"Triosephosphate_isomerase"}]},{"database":"PANTHER","id":"PTHR21139","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21139:SF42","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00121","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51351","properties":[{"key":"EntryName","value":"Triosephosphate isomerase (TIM)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51440","properties":[{"key":"EntryName","value":"TIM_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TPEEAVKVITELKPLVKDANCDVVICPTFVCLDAALKAAAGSNIKIGAQNMHFEEKGAFTGEVAPGMLQAMGVDYVVLGHSERREYFNETDEALNKKVKVAFAHNLTPILCCGETLEQRENGTTNEVVGAQIKADLEGLSKELAEKVVVAYEPI","length":154,"molWeight":16620,"crc64":"18D1733191DBF113","md5":"8C697C1699339277391FF83AFAB37A76"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI0001F5F14C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9LRU6","uniProtkbId":"E9LRU6_9CLOT","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":32,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77914.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Triosephosphate isomerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"5.3.1.1"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77914.1"}],"value":"tpi"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18585"},{"database":"ChEBI","id":"CHEBI:57642"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"5.3.1.1","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate biosynthesis; gluconeogenesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007422"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Belongs to the triosephosphate isomerase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77914.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77914.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0312","category":"Biological process","name":"Gluconeogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0324","category":"Biological process","name":"Glycolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"21182874","citationType":"journal article","authors":["Garofolo G.","Galante D.","Serrecchia L.","Buonavoglia D.","Fasanella A."],"citationCrossReferences":[{"database":"PubMed","id":"21182874"},{"database":"DOI","id":"10.1016/j.mimet.2010.12.017"}],"title":"Development of a real time PCR Taqman assay based on the TPI gene for simultaneous identification of Clostridium chauvoei and Clostridium septicum.","publicationDate":"2011","journal":"J. Microbiol. Methods","firstPage":"307","lastPage":"311","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77914.1"}],"value":"C2_1","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77914.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ123268","properties":[{"key":"ProteinId","value":"ADV77914.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9LRU6","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00109","properties":[{"key":"RectionId","value":"UER00189"}]},{"database":"UniPathway","id":"UPA00138","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004807","properties":[{"key":"GoTerm","value":"F:triose-phosphate isomerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006094","properties":[{"key":"GoTerm","value":"P:gluconeogenesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0046166","properties":[{"key":"GoTerm","value":"P:glyceraldehyde-3-phosphate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019563","properties":[{"key":"GoTerm","value":"P:glycerol catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006096","properties":[{"key":"GoTerm","value":"P:glycolytic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd00311","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR035990","properties":[{"key":"EntryName","value":"TIM_sf"}]},{"database":"InterPro","id":"IPR000652","properties":[{"key":"EntryName","value":"Triosephosphate_isomerase"}]},{"database":"PANTHER","id":"PTHR21139","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21139:SF42","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00121","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51351","properties":[{"key":"EntryName","value":"Triosephosphate isomerase (TIM)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51440","properties":[{"key":"EntryName","value":"TIM_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TPEEAVKVITELKPLVKDANCDVVICPTFVCLDAALKAAAGSNIKIGAQNMHFEEKGAFTGEVAPGMLQAMGVDYVVLGHSERREYFNETDEALNKKVKVAFAHNLTPILCCGETLEQRENGTTNEVVGAQIKADLEGLSKELAEKVVVAYEPIW","length":155,"molWeight":16806,"crc64":"6AD8D1733191DBF1","md5":"5515BD9F852402FDFF951D9580FDEB1E"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI0001F5F14D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9LRU7","uniProtkbId":"E9LRU7_9CLOT","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":35,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77915.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Triosephosphate isomerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"5.3.1.1"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77915.1"}],"value":"tpi"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18585"},{"database":"ChEBI","id":"CHEBI:57642"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"5.3.1.1","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate biosynthesis; gluconeogenesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007422"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Belongs to the triosephosphate isomerase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77915.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77915.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0312","category":"Biological process","name":"Gluconeogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0324","category":"Biological process","name":"Glycolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"21182874","citationType":"journal article","authors":["Garofolo G.","Galante D.","Serrecchia L.","Buonavoglia D.","Fasanella A."],"citationCrossReferences":[{"database":"PubMed","id":"21182874"},{"database":"DOI","id":"10.1016/j.mimet.2010.12.017"}],"title":"Development of a real time PCR Taqman assay based on the TPI gene for simultaneous identification of Clostridium chauvoei and Clostridium septicum.","publicationDate":"2011","journal":"J. Microbiol. Methods","firstPage":"307","lastPage":"311","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77931.1"}],"value":"540","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77932.1"}],"value":"ATCC 1092","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77923.1"}],"value":"ATCC 19399","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77915.1"}],"value":"C2_2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77918.1"}],"value":"C4_11","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77919.1"}],"value":"C4_12","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77924.1"}],"value":"FD472","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77925.1"}],"value":"FD473","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77926.1"}],"value":"FD477","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77927.1"}],"value":"FD480","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77928.1"}],"value":"FD481","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77929.1"}],"value":"FD482","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77930.1"}],"value":"FD483","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77921.1"}],"value":"IZS08/09","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77915.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ123269","properties":[{"key":"ProteinId","value":"ADV77915.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123272","properties":[{"key":"ProteinId","value":"ADV77918.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123273","properties":[{"key":"ProteinId","value":"ADV77919.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123275","properties":[{"key":"ProteinId","value":"ADV77921.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123277","properties":[{"key":"ProteinId","value":"ADV77923.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123278","properties":[{"key":"ProteinId","value":"ADV77924.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123279","properties":[{"key":"ProteinId","value":"ADV77925.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123280","properties":[{"key":"ProteinId","value":"ADV77926.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123281","properties":[{"key":"ProteinId","value":"ADV77927.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123282","properties":[{"key":"ProteinId","value":"ADV77928.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123283","properties":[{"key":"ProteinId","value":"ADV77929.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123284","properties":[{"key":"ProteinId","value":"ADV77930.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123285","properties":[{"key":"ProteinId","value":"ADV77931.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"HQ123286","properties":[{"key":"ProteinId","value":"ADV77932.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9LRU7","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00109","properties":[{"key":"RectionId","value":"UER00189"}]},{"database":"UniPathway","id":"UPA00138","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004807","properties":[{"key":"GoTerm","value":"F:triose-phosphate isomerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006094","properties":[{"key":"GoTerm","value":"P:gluconeogenesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0046166","properties":[{"key":"GoTerm","value":"P:glyceraldehyde-3-phosphate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019563","properties":[{"key":"GoTerm","value":"P:glycerol catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006096","properties":[{"key":"GoTerm","value":"P:glycolytic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd00311","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR035990","properties":[{"key":"EntryName","value":"TIM_sf"}]},{"database":"InterPro","id":"IPR000652","properties":[{"key":"EntryName","value":"Triosephosphate_isomerase"}]},{"database":"PANTHER","id":"PTHR21139","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21139:SF42","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00121","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51351","properties":[{"key":"EntryName","value":"Triosephosphate isomerase (TIM)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51440","properties":[{"key":"EntryName","value":"TIM_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TPEEAVKVITELKPLVKDANCDVVICPTFVCLDAALKAAAGSNIKIGAQNMHFEEKGAFTGEVAPGMLQAMGVDYVVLGHSERREYFNETDEALNKKVKVAFAHNLTPILCCGETLEQRENGTTNEVVGAQIKADLEGLSKELAEKVVVAYEPIWA","length":156,"molWeight":16877,"crc64":"F56AD8D1733191DB","md5":"0FABE16E87CD6F47C3FB28292A35B8DD"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI0001F5F14E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9LRU8","uniProtkbId":"E9LRU8_9CLOT","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":32,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77916.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Triosephosphate isomerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"5.3.1.1"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77916.1"}],"value":"tpi"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18585"},{"database":"ChEBI","id":"CHEBI:57642"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"5.3.1.1","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate biosynthesis; gluconeogenesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007422"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Belongs to the triosephosphate isomerase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77916.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77916.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0312","category":"Biological process","name":"Gluconeogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0324","category":"Biological process","name":"Glycolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"21182874","citationType":"journal article","authors":["Garofolo G.","Galante D.","Serrecchia L.","Buonavoglia D.","Fasanella A."],"citationCrossReferences":[{"database":"PubMed","id":"21182874"},{"database":"DOI","id":"10.1016/j.mimet.2010.12.017"}],"title":"Development of a real time PCR Taqman assay based on the TPI gene for simultaneous identification of Clostridium chauvoei and Clostridium septicum.","publicationDate":"2011","journal":"J. Microbiol. Methods","firstPage":"307","lastPage":"311","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77916.1"}],"value":"C2_3","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADV77916.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ123270","properties":[{"key":"ProteinId","value":"ADV77916.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E9LRU8","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00109","properties":[{"key":"RectionId","value":"UER00189"}]},{"database":"UniPathway","id":"UPA00138","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004807","properties":[{"key":"GoTerm","value":"F:triose-phosphate isomerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006094","properties":[{"key":"GoTerm","value":"P:gluconeogenesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0046166","properties":[{"key":"GoTerm","value":"P:glyceraldehyde-3-phosphate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019563","properties":[{"key":"GoTerm","value":"P:glycerol catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006096","properties":[{"key":"GoTerm","value":"P:glycolytic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd00311","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR035990","properties":[{"key":"EntryName","value":"TIM_sf"}]},{"database":"InterPro","id":"IPR000652","properties":[{"key":"EntryName","value":"Triosephosphate_isomerase"}]},{"database":"PANTHER","id":"PTHR21139","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21139:SF42","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00121","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51351","properties":[{"key":"EntryName","value":"Triosephosphate isomerase (TIM)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51440","properties":[{"key":"EntryName","value":"TIM_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TPEEAVKVITELKPLVKDANCDVVICPTFVCLDAALKAAAGSNIKIGAQNMHFEEKGAFTGEVAPGMLQAMGVDYVVLGHSERREYFNETDEALNKKVKVAFAHNLTPILCCGETLEQRENGTTNEVVGAQIKADLEGLSKELAEKVVVAYEPT","length":154,"molWeight":16608,"crc64":"0921733191DBF113","md5":"1119CF984F5DDA1858EBCC8C9CF25F08"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI0001F5F14F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"D6MSD2","uniProtkbId":"D6MSD2_9CLOT","entryAudit":{"firstPublicDate":"2010-07-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2010-07-13","entryVersion":58,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64881.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00018672"}],"value":"Stage 0 sporulation protein A homolog"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64881.1"}],"value":"spo0A"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024867"}],"value":"May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"Ca(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001913"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29108"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Response regulatory","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50110"}]},{"type":"Modified residue","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"4-aspartylphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64881.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64881.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023159"}],"id":"KW-0010","category":"Molecular function","name":"Activator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022491"}],"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022969"}],"id":"KW-0749","category":"Biological process","name":"Sporulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023012"}],"id":"KW-0902","category":"Biological process","name":"Two-component regulatory system"}],"references":[{"referenceNumber":1,"citation":{"id":"20362050","citationType":"journal article","authors":["Lange M.","Neubauer H.","Seyboldt C."],"citationCrossReferences":[{"database":"PubMed","id":"20362050"},{"database":"DOI","id":"10.1016/j.mcp.2010.03.003"}],"title":"Development and validation of a multiplex real-time PCR for detection of Clostridium chauvoei and Clostridium septicum.","publicationDate":"2010","journal":"Mol. Cell. Probes","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64881.1"}],"value":"ATCC 10092","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64881.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GQ401117","properties":[{"key":"ProteinId","value":"ADG64881.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"D6MSD2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0032993","properties":[{"key":"GoTerm","value":"C:protein-DNA complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000156","properties":[{"key":"GoTerm","value":"F:phosphorelay response regulator activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051606","properties":[{"key":"GoTerm","value":"P:detection of stimulus"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042173","properties":[{"key":"GoTerm","value":"P:regulation of sporulation resulting in formation of a cellular spore"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011006","properties":[{"key":"EntryName","value":"CheY-like_sf"}]},{"database":"InterPro","id":"IPR016032","properties":[{"key":"EntryName","value":"Sig_transdc_resp-reg_C-effctor"}]},{"database":"InterPro","id":"IPR001789","properties":[{"key":"EntryName","value":"Sig_transdc_resp-reg_receiver"}]},{"database":"InterPro","id":"IPR014879","properties":[{"key":"EntryName","value":"Spo0A_C"}]},{"database":"InterPro","id":"IPR012052","properties":[{"key":"EntryName","value":"Spore_0_A"}]},{"database":"InterPro","id":"IPR039420","properties":[{"key":"EntryName","value":"WalR-like"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"NCBIfam","id":"TIGR02875","properties":[{"key":"EntryName","value":"spore_0_A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48111","properties":[{"key":"EntryName","value":"REGULATOR OF RPOS"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48111:SF1","properties":[{"key":"EntryName","value":"TWO-COMPONENT RESPONSE REGULATOR ORR33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00072","properties":[{"key":"EntryName","value":"Response_reg"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08769","properties":[{"key":"EntryName","value":"Spo0A_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00448","properties":[{"key":"EntryName","value":"REC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46894","properties":[{"key":"EntryName","value":"C-terminal effector domain of the bipartite response regulators"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52172","properties":[{"key":"EntryName","value":"CheY-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50110","properties":[{"key":"EntryName","value":"RESPONSE_REGULATORY"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"KEFCSILNDYLLNQRDIVVTGVAKDGREALALIEEKKPDLVVLDIIMPHLDGLGVLEKLNTMNLEKMPRIIVLSAVGQDKITQRAITLGADYYVVKPFDMDVFTKRIREMFNGAPTESIRKTTTVVETEVATQAKGPIDLETEITNIIHEIGVPAHIKGYMYLREAITMVVNDMELLSAVTKELYPSIAKK","length":191,"molWeight":21388,"crc64":"39F22651396688E4","md5":"BF8D84CB2F837A211BAE0D559414FE01"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Modified residue":1,"Non-terminal residue":2},"uniParcId":"UPI0001D2C3D3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q8RRA1","uniProtkbId":"Q8RRA1_9CLOT","entryAudit":{"firstPublicDate":"2002-06-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2002-06-01","entryVersion":70,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87728.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020110"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Flagellin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87728.1"}],"value":"fliB(C)"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Bacterial flagellum","id":"SL-0307"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005709"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Belongs to the bacterial flagellin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Flagellin N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00669"}]},{"type":"Domain","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Flagellin C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00700"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023143"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"id":"KW-0975","category":"Cellular component","name":"Bacterial flagellum"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87728.1"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87728.1"}],"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87728.1"}],"id":"KW-0282","category":"Cellular component","name":"Flagellum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"}],"references":[{"referenceNumber":1,"citation":{"id":"11900959","citationType":"journal article","authors":["Sasaki Y.","Kojima A.","Aoki H.","Ogikubo Y.","Takikawa N.","Tamura Y."],"citationCrossReferences":[{"database":"PubMed","id":"11900959"},{"database":"DOI","id":"10.1016/S0378-1135(02)00002-0"}],"title":"Phylogenetic analysis and PCR detection of Clostridium chauvoei, Clostridium haemolyticum, Clostridium novyi types A and B, and Clostridium septicum based on the flagellin gene.","publicationDate":"2002","journal":"Vet. Microbiol.","firstPage":"257","lastPage":"267","volume":"86"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87728.1"}],"value":"ATCC10092","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87728.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB058932","properties":[{"key":"ProteinId","value":"BAB87728.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_079481225.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP018624.1"}]},{"database":"AlphaFoldDB","id":"Q8RRA1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"66301215","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"cchv:BTM20_05000","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009288","properties":[{"key":"GoTerm","value":"C:bacterial-type flagellum"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"3.30.70.2120","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1330.10","properties":[{"key":"EntryName","value":"f41 fragment of flagellin, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.10.10","properties":[{"key":"EntryName","value":"Flagellar export chaperone, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001492","properties":[{"key":"EntryName","value":"Flagellin"}]},{"database":"InterPro","id":"IPR046358","properties":[{"key":"EntryName","value":"Flagellin_C"}]},{"database":"InterPro","id":"IPR042187","properties":[{"key":"EntryName","value":"Flagellin_C_sub2"}]},{"database":"InterPro","id":"IPR001029","properties":[{"key":"EntryName","value":"Flagellin_N"}]},{"database":"PANTHER","id":"PTHR42792","properties":[{"key":"EntryName","value":"FLAGELLIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42792:SF2","properties":[{"key":"EntryName","value":"FLAGELLIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00700","properties":[{"key":"EntryName","value":"Flagellin_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00669","properties":[{"key":"EntryName","value":"Flagellin_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00207","properties":[{"key":"EntryName","value":"FLAGELLIN"}]},{"database":"SUPFAM","id":"SSF64518","properties":[{"key":"EntryName","value":"Phase 1 flagellin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIINHNMNALNAHRNMMGNIATAGKSMEKLSSGLRINRAGDDAAGLAISEKMRGQIRGLDQASRNAQDGISLIQTAEGALSETHSILQRMRELSVQSANDTNVAVDRTAIQDEINSLTEEINRISGDTEFNTQKLLDGGFKGEFQIGANSNQTVKLDIGNMSAASLGLTTTNSLESKALALNSNLADGSYKISGTNLVDTNGNTVGTFNSGAKKIVVNGQDTVFTKAALADGAVLTVKGGIADIKNTMTGAAKKLSSGSYEISGTNVIKDGKLVGTFATGAKKLTIDGVGDVTEAELGFITDQMKDGVKFTINGSDVSTRELASGSIKTINSAIEQVSTQRSKLGAVQNRLEHTINNLNTSSENLTAAESRVRDVDMAKEMMAFSKNNILSQAAQAMLGQANQQPQGVLQLLR","length":413,"molWeight":43545,"crc64":"72FA065B0AA46942","md5":"2E1E8FF13FB366C5EEFB3426DE4E7EFD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI00000B6E6E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9F4A4","uniProtkbId":"Q9F4A4_9CLOT","entryAudit":{"firstPublicDate":"2001-03-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2001-03-01","entryVersion":83,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB13814.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020110"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Flagellin"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB13814.1"}],"value":"fliC"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87726.1"}],"value":"fliA(C)"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Bacterial flagellum","id":"SL-0307"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005709"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"value":"Belongs to the bacterial flagellin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Flagellin N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00669"}]},{"type":"Domain","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Flagellin C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00700"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023143"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"id":"KW-0975","category":"Cellular component","name":"Bacterial flagellum"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB13814.1"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB13814.1"}],"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB13814.1"}],"id":"KW-0282","category":"Cellular component","name":"Flagellum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362073"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"}],"references":[{"referenceNumber":1,"citation":{"id":"11000532","citationType":"journal article","authors":["Kojima A.","Uchida I.","Sekizaki T.","Sasaki Y.","Ogikubo Y.","Kijima M.","Tamura Y."],"citationCrossReferences":[{"database":"PubMed","id":"11000532"},{"database":"DOI","id":"10.1016/S0378-1135(00)00256-X"}],"title":"Cloning and expression of a gene encoding the flagellin of Clostridium chauvoei.","publicationDate":"2000","journal":"Vet. Microbiol.","firstPage":"359","lastPage":"372","volume":"76"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB13814.1"}],"value":"Okinawa","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB13814.1"}]},{"referenceNumber":2,"citation":{"id":"11900959","citationType":"journal article","authors":["Sasaki Y.","Kojima A.","Aoki H.","Ogikubo Y.","Takikawa N.","Tamura Y."],"citationCrossReferences":[{"database":"PubMed","id":"11900959"},{"database":"DOI","id":"10.1016/S0378-1135(02)00002-0"}],"title":"Phylogenetic analysis and PCR detection of Clostridium chauvoei, Clostridium haemolyticum, Clostridium novyi types A and B, and Clostridium septicum based on the flagellin gene.","publicationDate":"2002","journal":"Vet. Microbiol.","firstPage":"257","lastPage":"267","volume":"86"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87726.1"}],"value":"ATCC10092","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAB87726.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D89073","properties":[{"key":"ProteinId","value":"BAB13814.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB058931","properties":[{"key":"ProteinId","value":"BAB87726.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_079481224.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP018624.1"}]},{"database":"AlphaFoldDB","id":"Q9F4A4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9F4A4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009288","properties":[{"key":"GoTerm","value":"C:bacterial-type flagellum"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"3.30.70.2120","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1330.10","properties":[{"key":"EntryName","value":"f41 fragment of flagellin, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.10.10","properties":[{"key":"EntryName","value":"Flagellar export chaperone, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001492","properties":[{"key":"EntryName","value":"Flagellin"}]},{"database":"InterPro","id":"IPR046358","properties":[{"key":"EntryName","value":"Flagellin_C"}]},{"database":"InterPro","id":"IPR042187","properties":[{"key":"EntryName","value":"Flagellin_C_sub2"}]},{"database":"InterPro","id":"IPR001029","properties":[{"key":"EntryName","value":"Flagellin_N"}]},{"database":"PANTHER","id":"PTHR42792","properties":[{"key":"EntryName","value":"FLAGELLIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42792:SF2","properties":[{"key":"EntryName","value":"FLAGELLIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00700","properties":[{"key":"EntryName","value":"Flagellin_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00669","properties":[{"key":"EntryName","value":"Flagellin_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00207","properties":[{"key":"EntryName","value":"FLAGELLIN"}]},{"database":"SUPFAM","id":"SSF64518","properties":[{"key":"EntryName","value":"Phase 1 flagellin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIINHNMNALNAHRNMMGNIATAGKSMEKLSSGLRINRAGDDAAGLAISEKMRGQIRGLDQASRNAQDGISLIQTAEGALAETHSILQRMRELSVQSANDTNVAVDRTAIQDEINSLTEEINRISGDTEFNTQKLLDGGFKGEFQIGANSNQTVKLDIGNMSAASLGLTTTNSLESKALTKDSNLADGTYKISGKNLVDTNGNSVGTFDAASKKITVNGKDTVFDKAALAENAVLTVKSGTAEIKNTMTGAATKLSSGNYEIKGTNVIKDGKLAGTFDAAKKKLTIDGVGDVSEAELGFQTSKMLDKVSFTINGSDVSTRELASGSIKTINSAIEQVSTQRSKLGAVQNRLEHTINNLNTSSENLTAAESRVRDVDMAKEMMAFSKNNILSQAAQAMLGQANQQPQGVLQLLR","length":413,"molWeight":43822,"crc64":"6AEAD38D0BE80FE2","md5":"38431404D433BF9F02B751100228D57D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI00000B8675"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"D6N3A4","uniProtkbId":"D6N3A4_9CLOT","entryAudit":{"firstPublicDate":"2010-07-13","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2010-07-13","entryVersion":42,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64884.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020110"}],"value":"Flagellin"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64884.1"}],"value":"fliC"}}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Flagellin N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00669"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64884.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64884.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64884.1"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64884.1"}],"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64884.1"}],"id":"KW-0282","category":"Cellular component","name":"Flagellum"}],"references":[{"referenceNumber":1,"citation":{"id":"20362050","citationType":"journal article","authors":["Lange M.","Neubauer H.","Seyboldt C."],"citationCrossReferences":[{"database":"PubMed","id":"20362050"},{"database":"DOI","id":"10.1016/j.mcp.2010.03.003"}],"title":"Development and validation of a multiplex real-time PCR for detection of Clostridium chauvoei and Clostridium septicum.","publicationDate":"2010","journal":"Mol. Cell. Probes","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64884.1"}],"value":"BS171-00","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64884.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GU266538","properties":[{"key":"ProteinId","value":"ADG64884.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"D6N3A4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009288","properties":[{"key":"GoTerm","value":"C:bacterial-type flagellum"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1330.10","properties":[{"key":"EntryName","value":"f41 fragment of flagellin, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001492","properties":[{"key":"EntryName","value":"Flagellin"}]},{"database":"InterPro","id":"IPR001029","properties":[{"key":"EntryName","value":"Flagellin_N"}]},{"database":"PANTHER","id":"PTHR42792","properties":[{"key":"EntryName","value":"FLAGELLIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42792:SF2","properties":[{"key":"EntryName","value":"FLAGELLIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00669","properties":[{"key":"EntryName","value":"Flagellin_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00207","properties":[{"key":"EntryName","value":"FLAGELLIN"}]},{"database":"SUPFAM","id":"SSF64518","properties":[{"key":"EntryName","value":"Phase 1 flagellin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GDDAAGLAISEKMRGQIRGLDQASRNAQDGISLIQTAEGALAETHSILQRMRELSVQSANDTNVAVDRTAIQDEINSLTEEINRISGDTEFNTQKLLDGGFKGEFQIGANSNQTVKLDIGNMSAASLGLTTTNSLESKALALNSNLADGSYKISGTNLVDTNGNTVGTFNSGAKKIVVNGQDTVFTKAALADGAV","length":195,"molWeight":20349,"crc64":"02B15F416C061476","md5":"F4E606135B4D756A294D8582B3F7BB44"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0001D2C627"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"D6N3A5","uniProtkbId":"D6N3A5_9CLOT","entryAudit":{"firstPublicDate":"2010-07-13","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2010-07-13","entryVersion":40,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64885.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020110"}],"value":"Flagellin"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64885.1"}],"value":"fliC"}}],"features":[{"type":"Domain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Flagellin N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00669"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64885.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64885.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64885.1"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64885.1"}],"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64885.1"}],"id":"KW-0282","category":"Cellular component","name":"Flagellum"}],"references":[{"referenceNumber":1,"citation":{"id":"20362050","citationType":"journal article","authors":["Lange M.","Neubauer H.","Seyboldt C."],"citationCrossReferences":[{"database":"PubMed","id":"20362050"},{"database":"DOI","id":"10.1016/j.mcp.2010.03.003"}],"title":"Development and validation of a multiplex real-time PCR for detection of Clostridium chauvoei and Clostridium septicum.","publicationDate":"2010","journal":"Mol. Cell. Probes","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64885.1"}],"value":"BC138-06","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADG64885.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GU266539","properties":[{"key":"ProteinId","value":"ADG64885.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"GO","id":"GO:0009288","properties":[{"key":"GoTerm","value":"C:bacterial-type flagellum"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005198","properties":[{"key":"GoTerm","value":"F:structural molecule activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.1330.10","properties":[{"key":"EntryName","value":"f41 fragment of flagellin, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001492","properties":[{"key":"EntryName","value":"Flagellin"}]},{"database":"InterPro","id":"IPR001029","properties":[{"key":"EntryName","value":"Flagellin_N"}]},{"database":"PANTHER","id":"PTHR42792","properties":[{"key":"EntryName","value":"FLAGELLIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42792:SF2","properties":[{"key":"EntryName","value":"FLAGELLIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00669","properties":[{"key":"EntryName","value":"Flagellin_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00207","properties":[{"key":"EntryName","value":"FLAGELLIN"}]},{"database":"SUPFAM","id":"SSF64518","properties":[{"key":"EntryName","value":"Phase 1 flagellin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GDDAAGLAISEKMRGQIRGLDQASRNAQDGISLIQTAEGALXETHSILQRMRELSVQSANDTNVAVDRTAIQDEINSLTEEINRISGDTEFNTQKLLDGGFKGEFQIGANSNQTVKLDIGNMSAASLGLTTTNSLESKALALNSNLADGSYKISGTNLVDTNGNTVGTFNSGAKKIVVNGQDTVFTKAALADGAV","length":195,"molWeight":20390,"crc64":"C0DBBCB4CD8F146E","md5":"9C2DA3DA6F0E2CF202E96585424C6839"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0001D2C628"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I6VBE8","uniProtkbId":"I6VBE8_9CLOT","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2012-10-03","entryVersion":34,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Clostridium chauvoei","taxonId":46867,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFN24559.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFN24559.1"}],"value":"CctA"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFN24559.1"}],"value":"cctA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009831"}],"value":"Belongs to the aerolysin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5007674268"},{"type":"Domain","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Leukocidin/Hemolysin toxin","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF07968"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"22749595","citationType":"journal article","authors":["Frey J.","Johansson A.","Burki S.","Vilei E.M.","Redhead K."],"citationCrossReferences":[{"database":"PubMed","id":"22749595"},{"database":"DOI","id":"10.1016/j.vaccine.2012.06.050"}],"title":"Cytotoxin CctA, a major virulence factor of Clostridium chauvoei conferring protective immunity against myonecrosis.","publicationDate":"2012","journal":"Vaccine","firstPage":"0","lastPage":"0","volume":"0"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFN27591.1"}],"value":"ATCC 10092","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFN24559.1"}],"value":"JF3703","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFN24559.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ728486","properties":[{"key":"ProteinId","value":"AFN24559.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"JQ692583","properties":[{"key":"ProteinId","value":"AFN27591.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_021874975.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP018624.1"}]},{"database":"AlphaFoldDB","id":"I6VBE8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"I6VBE8","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.C.3.2.5","properties":[{"key":"FamilyName","value":"the Alpha-hemolysin channel-forming toxin (Alphahl) family"}]},{"database":"GeneID","id":"66300987","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"cchv:BTM20_03860","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0051715","properties":[{"key":"GoTerm","value":"P:cytolysis in another organism"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.70.240.10","properties":[{"key":"EntryName","value":"Leukocidin/porin MspA"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003963","properties":[{"key":"EntryName","value":"Bi-component_toxin_staph"}]},{"database":"InterPro","id":"IPR016183","properties":[{"key":"EntryName","value":"Leukocidin/Hemolysin_toxin"}]},{"database":"InterPro","id":"IPR036435","properties":[{"key":"EntryName","value":"Leukocidin/porin_MspA_sf"}]},{"database":"NCBIfam","id":"TIGR01002","properties":[{"key":"EntryName","value":"hlyII"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07968","properties":[{"key":"EntryName","value":"Leukocidin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01468","properties":[{"key":"EntryName","value":"BICOMPNTOXIN"}]},{"database":"SUPFAM","id":"SSF56959","properties":[{"key":"EntryName","value":"Leukocidin-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIKRILMLALATTTIFSLTLPFSYKAVQAQENTCIVETPSEGVKTFTSSDTAYADYNCFKTNLSVTFIEDQHNNQLTALVSTEGSFIPSGLSRVGGYYQADMYWPSKYYTTLTTYDRNNRVKITKSIPTNQIDTVSVSETMGYSIGGSLSIEYGKEGPKAGGGINGSYTAQRSVTYDQPDYRTLLMKDSVNSASWEVAFNATKDGYDRDSYHGIYGNQLFMRYRLYNTGINNLTTDNNLSSLIVGGFSPKVVIALTAPKGTEESTVKVEYNRFNDQYRLRWSGTEWYGENNRNSRIDSSSESFILNWKNHTVEHAGY","length":317,"molWeight":35572,"crc64":"67F01FDC57BA8F50","md5":"ED473DB423A5086F2BF2F461F93C73A5"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1},"uniParcId":"UPI0001ED07F7"}}]}