{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7E4Y1","uniProtkbId":"I7E4Y1_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":31,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84305.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019595"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"dTDP-4-dehydrorhamnose 3,5-epimerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012098"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"5.1.3.13"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Thymidine diphospho-4-keto-rhamnose 3,5-epimerase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84305.1"}],"value":"rmlC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001997"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16969"},{"database":"ChEBI","id":"CHEBI:57649"},{"database":"ChEBI","id":"CHEBI:62830"}],"ecNumber":"5.1.3.13","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001298"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005125"}],"value":"Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004781"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010154"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Active site","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600888-1"}]},{"type":"Active site","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600888-1"}]},{"type":"Site","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600888-3"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023277"}],"id":"KW-0119","category":"Biological process","name":"Carbohydrate metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022985"}],"id":"KW-0448","category":"Biological process","name":"Lipopolysaccharide biosynthesis"}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84305.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84305.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84305.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7E4Y1","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00124","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008830","properties":[{"key":"GoTerm","value":"F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019305","properties":[{"key":"GoTerm","value":"P:dTDP-rhamnose biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000271","properties":[{"key":"GoTerm","value":"P:polysaccharide biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00438","properties":[{"key":"EntryName","value":"cupin_RmlC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.10:FF:000051","properties":[{"key":"EntryName","value":"dTDP-4-dehydrorhamnose 3,5-epimerase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.10","properties":[{"key":"EntryName","value":"Jelly Rolls"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000888","properties":[{"key":"EntryName","value":"RmlC-like"}]},{"database":"InterPro","id":"IPR014710","properties":[{"key":"EntryName","value":"RmlC-like_jellyroll"}]},{"database":"InterPro","id":"IPR011051","properties":[{"key":"EntryName","value":"RmlC_Cupin_sf"}]},{"database":"NCBIfam","id":"TIGR01221","properties":[{"key":"EntryName","value":"rmlC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21047","properties":[{"key":"EntryName","value":"DTDP-6-DEOXY-D-GLUCOSE-3,5 EPIMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21047:SF2","properties":[{"key":"EntryName","value":"THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE 3,5-EPIMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00908","properties":[{"key":"EntryName","value":"dTDP_sugar_isom"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51182","properties":[{"key":"EntryName","value":"RmlC-like cupins"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKVIQTAIPDVLILEPKVFGDDRGFFFESFNQRTFEEAIGRKVDFVQDNHSKSVKGVLRGLHFQRAPYAQGKLVRCIAGEVFDVAVDVRDGSSTFGHWVGVHLSSENKRQLWIPEGFAHGFLVLSDMAEFVYKTTNYYAPSHEAGIIWNDPTIDIKWPITDVILSEKDKTNVSLYEAVKSGDCND","length":185,"molWeight":20886,"crc64":"786754EED99BDBB6","md5":"359F8E30255175AFB689FE991CDC5A8D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"PATHWAY":2,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Active site":2,"Site":1},"uniParcId":"UPI000274E204"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"R4J9A4","uniProtkbId":"R4J9A4_9ENTR","entryAudit":{"firstPublicDate":"2013-07-24","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2013-07-24","entryVersion":24,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50607.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019595"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"dTDP-4-dehydrorhamnose 3,5-epimerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012098"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"5.1.3.13"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Thymidine diphospho-4-keto-rhamnose 3,5-epimerase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50607.1"}],"value":"rmlC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001997"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16969"},{"database":"ChEBI","id":"CHEBI:57649"},{"database":"ChEBI","id":"CHEBI:62830"}],"ecNumber":"5.1.3.13","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001298"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"value":"Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Active site","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600888-1"}]},{"type":"Active site","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600888-1"}]},{"type":"Site","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600888-3"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364069"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"23566272","citationType":"journal article","authors":["Jarvis K.G.","Yan Q.Q.","Grim C.J.","Power K.A.","Franco A.A.","Hu L.","Gopinath G.","Sathyamoorthy V.","Kotewicz M.L.","Kothary M.H.","Lee C.","Sadowski J.","Fanning S.","Tall B.D."],"citationCrossReferences":[{"database":"PubMed","id":"23566272"},{"database":"DOI","id":"10.1089/fpd.2012.1344"}],"title":"Identification and Characterization of Five New Molecular Serogroups of Cronobacter spp.","publicationDate":"2013","journal":"Foodborne Pathog. Dis.","firstPage":"343","lastPage":"352","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50607.1"}],"value":"E609","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50607.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX475926","properties":[{"key":"ProteinId","value":"AGJ50607.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_161588540.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JASCZX010000018.1"}]},{"database":"AlphaFoldDB","id":"R4J9A4","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00124","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008830","properties":[{"key":"GoTerm","value":"F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019305","properties":[{"key":"GoTerm","value":"P:dTDP-rhamnose biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000271","properties":[{"key":"GoTerm","value":"P:polysaccharide biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00438","properties":[{"key":"EntryName","value":"cupin_RmlC"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.10","properties":[{"key":"EntryName","value":"Jelly Rolls"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000888","properties":[{"key":"EntryName","value":"RmlC-like"}]},{"database":"InterPro","id":"IPR014710","properties":[{"key":"EntryName","value":"RmlC-like_jellyroll"}]},{"database":"InterPro","id":"IPR011051","properties":[{"key":"EntryName","value":"RmlC_Cupin_sf"}]},{"database":"NCBIfam","id":"TIGR01221","properties":[{"key":"EntryName","value":"rmlC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21047","properties":[{"key":"EntryName","value":"DTDP-6-DEOXY-D-GLUCOSE-3,5 EPIMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21047:SF2","properties":[{"key":"EntryName","value":"THYMIDINE DIPHOSPHO-4-KETO-RHAMNOSE 3,5-EPIMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00908","properties":[{"key":"EntryName","value":"dTDP_sugar_isom"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51182","properties":[{"key":"EntryName","value":"RmlC-like cupins"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNVIQTAIPDVLILEPKVFGDDRGFFFESFNQRIFEEVVGRKVEFVQDNHSKSAKGVLRGLHYQLAPHAQAKLVRCLQGAIYDVAVDIRLGSPTFGQWVGAELSAENKHQIWIPEGFAHGFIALEHDTEILYKTNDFYSKECERSIKWDDEQLNIAWPEKAGIISEKDAMAPAFSNADLFKK","length":182,"molWeight":20655,"crc64":"0394BA74283782C6","md5":"A04D62E13FE820FC8E38D6ADD452950E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Active site":2,"Site":1},"uniParcId":"UPI000332134A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7D756","uniProtkbId":"I7D756_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2012-10-03","entryVersion":37,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84303.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017099"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"dTDP-4-dehydrorhamnose reductase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012929"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"1.1.1.133"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84303.1"}],"value":"rmlD"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097277"}],"value":"Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS). Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21796"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57510"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:62830"}],"ecNumber":"1.1.1.133","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048200"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"Binds 1 Mg(2+) ion per monomer."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005125"}],"value":"Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004781"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"Belongs to the dTDP-4-dehydrorhamnose reductase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"RmlD-like substrate binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04321"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84303.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84303.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84303.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7D756","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00124","properties":[{"key":"RectionId","value":"-"}]},{"database":"UniPathway","id":"UPA00281","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008831","properties":[{"key":"GoTerm","value":"F:dTDP-4-dehydrorhamnose reductase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0019305","properties":[{"key":"GoTerm","value":"P:dTDP-rhamnose biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0009243","properties":[{"key":"GoTerm","value":"P:O antigen biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd05254","properties":[{"key":"EntryName","value":"dTDP_HR_like_SDR_e"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000159","properties":[{"key":"EntryName","value":"dTDP-4-dehydrorhamnose reductase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.25.10","properties":[{"key":"EntryName","value":"UDP-galactose 4-epimerase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR005913","properties":[{"key":"EntryName","value":"RmlD"}]},{"database":"InterPro","id":"IPR029903","properties":[{"key":"EntryName","value":"RmlD-like-bd"}]},{"database":"NCBIfam","id":"NF007440","properties":[{"key":"EntryName","value":"rfbD"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01214","properties":[{"key":"EntryName","value":"rmlD"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10491","properties":[{"key":"EntryName","value":"DTDP-4-DEHYDRORHAMNOSE REDUCTASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10491:SF4","properties":[{"key":"EntryName","value":"METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04321","properties":[{"key":"EntryName","value":"RmlD_sub_bind"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNILLFGKNGQVGWELQRALSPLGNLISLDFNSEDYCGDFSNPEGVAETVRRIKPDVIVNAAAHTAVDKAESEREFAQLLNATSVEAIAREATKINAWLIHYSTDYVFPGTGETPWCESDATAPLNVYGETKLAGEQAVQRFCPNHLIFRTSWVYAGKGNNFAKTMLRLAKERESLSVINDQYGAPTGAELLADCTAHAIRVALTKPDVAGLYHLVASGVTTWYDFAALVFDQARKAGITLKLTDLQPVPTSAYPTPARRPQNSRLNTMKFQQQFGLMLPQWDVGVKRMLEEWFTAGI","length":298,"molWeight":32930,"crc64":"85E9CCE748057864","md5":"F200B893E457F3AE2853F59ABC820595"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":2,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI000274E202"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7EEI3","uniProtkbId":"I7EEI3_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2012-10-03","entryVersion":32,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84304.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012461"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"value":"Glucose-1-phosphate thymidylyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012461"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"value":"2.7.7.24"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84304.1"}],"value":"rmlA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"value":"Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTTP + alpha-D-glucose 1-phosphate + H(+) = dTDP-alpha-D-glucose + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15225"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37568"},{"database":"ChEBI","id":"CHEBI:57477"},{"database":"ChEBI","id":"CHEBI:58601"}],"ecNumber":"2.7.7.24","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049336"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005125"}],"value":"Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004781"}],"value":"Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010480"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"value":"Belongs to the glucose-1-phosphate thymidylyltransferase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Nucleotidyl transferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00483"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84304.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84304.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84304.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7EEI3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0008879","properties":[{"key":"GoTerm","value":"F:glucose-1-phosphate thymidylyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"CDD","id":"cd02538","properties":[{"key":"EntryName","value":"G1P_TT_short"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.550.10:FF:000023","properties":[{"key":"EntryName","value":"Glucose-1-phosphate thymidylyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.550.10","properties":[{"key":"EntryName","value":"Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005907","properties":[{"key":"EntryName","value":"G1P_thy_trans_s"}]},{"database":"InterPro","id":"IPR005835","properties":[{"key":"EntryName","value":"NTP_transferase_dom"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"NCBIfam","id":"NF012024","properties":[{"key":"EntryName","value":"rfbA"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01207","properties":[{"key":"EntryName","value":"rmlA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43532","properties":[{"key":"EntryName","value":"GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43532:SF1","properties":[{"key":"EntryName","value":"GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00483","properties":[{"key":"EntryName","value":"NTP_transferase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MWVLNACLKSGSLPEFNDRNALYRAFRIVRIKKMITRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFEQLLGNGSQWGLNLQYKVQSSPDGLAQAFIIGEEFIGNDKCALVLGDNIFYGHDLPKQLESAVSKENGATVFAYHVNDPERYGVVEFDKSGKAISLEEKPAEPKSNYAVTGLYFYDNNVVEMAKSLKPSARGELEITDINRLYLEQGRLNVAMMGRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAFRKGFIDAEQVKRLAQPLSKNAYGQYLLKMIKGY","length":325,"molWeight":36370,"crc64":"E1DF308EA16B15CB","md5":"AB70CD37D133E336E782C0AE6BDD45C3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":2,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI000274E203"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7EGV1","uniProtkbId":"I7EGV1_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2025-06-18","lastSequenceUpdateDate":"2012-10-03","entryVersion":40,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84302.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011990"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"value":"dTDP-glucose 4,6-dehydratase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011990"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"value":"4.2.1.46"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84302.1"}],"value":"rmlB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17221"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:57477"},{"database":"ChEBI","id":"CHEBI:57649"}],"ecNumber":"4.2.1.46","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001539"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"NAD(+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001911"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57540"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008178"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"value":"Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"NAD(P)-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF16363"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"}],"id":"KW-0520","category":"Ligand","name":"NAD"}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84302.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84302.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84302.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7EGV1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0008460","properties":[{"key":"GoTerm","value":"F:dTDP-glucose 4,6-dehydratase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0009225","properties":[{"key":"GoTerm","value":"P:nucleotide-sugar metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd05246","properties":[{"key":"EntryName","value":"dTDP_GD_SDR_e"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000108","properties":[{"key":"EntryName","value":"dTDP-glucose 4,6-dehydratase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.25.10","properties":[{"key":"EntryName","value":"UDP-galactose 4-epimerase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005888","properties":[{"key":"EntryName","value":"dTDP_Gluc_deHydtase"}]},{"database":"InterPro","id":"IPR016040","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"NCBIfam","id":"TIGR01181","properties":[{"key":"EntryName","value":"dTDP_gluc_dehyt"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF007490","properties":[{"key":"EntryName","value":"PRK10084.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43000","properties":[{"key":"EntryName","value":"DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16363","properties":[{"key":"EntryName","value":"GDP_Man_Dehyd"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKILVTGGAGFIGSAVVRHIINHTQDRVVNLDKLTYAGNPESVASVANSERYAFEQVDICDRAALDRVFKEHQPDAVMHLAAESHVDRSISGPADFIETNIVGTYTLLEAARAYWSSLDEQRKAAFRFHHISTDEVYGDLPRPDEWHESAALPLFTETTAYAPSSPYSASKASSDHLVRAWLRTYGLPTMVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDHARALYTVVTQGQIGETYNIGGHNEKKNLDVVLTICDLLDEIKPKATSYREQITYVADRPGHDRRYAIDADKISRELGWQPQETFESGIRKTVHWYLENSQWVENVKSGAYKSWIEQNYGAR","length":360,"molWeight":40662,"crc64":"B48A6176475C7F71","md5":"26D93C389AFC81564FA390250CA5BBDB"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI000274E201"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7FEQ7","uniProtkbId":"I7FEQ7_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":38,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFP23367.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"DNA topoisomerase (ATP-hydrolyzing)"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"5.6.2.2"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFP23367.1"}],"value":"gyrB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP-dependent breakage, passage and rejoining of double-stranded DNA.","ecNumber":"5.6.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000185"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010708"}],"value":"Belongs to the type II topoisomerase GyrB family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"DNA topoisomerase type IIA subunit B","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00204"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFP23367.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFP23367.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023029"}],"id":"KW-0799","category":"Molecular function","name":"Topoisomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-BK2TSB1UJ3MEL","citationType":"submission","authors":["Huang C.-H."],"publicationDate":"MAY-2012","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFP23367.1"}],"value":"BCRC 17994","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFP23367.1"}]},{"referenceNumber":2,"citation":{"id":"22963906","citationType":"journal article","authors":["Huang C.H.","Chang M.T.","Huang L."],"citationCrossReferences":[{"database":"PubMed","id":"22963906"},{"database":"DOI","id":"10.1016/j.mcp.2012.08.004"}],"title":"Use of novel species-specific PCR primers targeted to DNA gyrase subunit B (gyrB) gene for species identification of the Cronobacter sakazakii and Cronobacter dublinensis.","publicationDate":"2013","journal":"Mol. Cell. Probes","firstPage":"15","lastPage":"18","volume":"27"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFP23367.1"}],"value":"BCRC 17994","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFP23367.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX088569","properties":[{"key":"ProteinId","value":"AFP23367.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7FEQ7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003918","properties":[{"key":"GoTerm","value":"F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006265","properties":[{"key":"GoTerm","value":"P:DNA topological change"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.30.230.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"InterPro","id":"IPR014721","properties":[{"key":"EntryName","value":"Ribsml_uS5_D2-typ_fold_subgr"}]},{"database":"InterPro","id":"IPR000565","properties":[{"key":"EntryName","value":"Topo_IIA_B"}]},{"database":"InterPro","id":"IPR013506","properties":[{"key":"EntryName","value":"Topo_IIA_bsu_dom2"}]},{"database":"PANTHER","id":"PTHR45866:SF1","properties":[{"key":"EntryName","value":"DNA GYRASE SUBUNIT B, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45866","properties":[{"key":"EntryName","value":"DNA GYRASE/TOPOISOMERASE SUBUNIT B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00204","properties":[{"key":"EntryName","value":"DNA_gyraseB"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01159","properties":[{"key":"EntryName","value":"DNAGYRASEB"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LELVIRREGKIHQQTYVHGVPQAPLAVTGDTEQTGTQVRFWPSHETFTNVTEFEYEILAKRLRELSFLNSGVSIRLVDKRDGKQDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAM","length":160,"molWeight":18344,"crc64":"F3948AA18515EDC8","md5":"9A399E749E0742AAD98F5020C0457F90"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000277631D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"K7RZJ6","uniProtkbId":"K7RZJ6_9ENTR","entryAudit":{"firstPublicDate":"2013-02-06","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2013-02-06","entryVersion":43,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFV94699.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019166"}],"value":"DNA gyrase subunit B"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"5.6.2.2"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFV94699.1"}],"value":"gyrB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP-dependent breakage, passage and rejoining of double-stranded DNA.","ecNumber":"5.6.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000185"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010708"}],"value":"Belongs to the type II topoisomerase GyrB family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"Toprim","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50880"}]},{"type":"Site","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00995"}]},{"type":"Site","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00995"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFV94699.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFV94699.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00995"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023029"}],"id":"KW-0799","category":"Molecular function","name":"Topoisomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"24102218","citationType":"journal article","authors":["Chen W.","Ai L.","Yang J.","Ren J.","Li Y.","Guo B."],"citationCrossReferences":[{"database":"PubMed","id":"24102218"}],"title":"Development of a PCR assay for rapid detection of Cronobacter spp. from food.","publicationDate":"2013","journal":"Can. J. Microbiol.","firstPage":"656","lastPage":"661","volume":"59"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFV94699.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX983610","properties":[{"key":"ProteinId","value":"AFV94699.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"K7RZJ6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003918","properties":[{"key":"GoTerm","value":"F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006265","properties":[{"key":"GoTerm","value":"P:DNA topological change"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00822","properties":[{"key":"EntryName","value":"TopoII_Trans_DNA_gyrase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.230.10:FF:000005","properties":[{"key":"EntryName","value":"DNA gyrase subunit B"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.230.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.670","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"InterPro","id":"IPR014721","properties":[{"key":"EntryName","value":"Ribsml_uS5_D2-typ_fold_subgr"}]},{"database":"InterPro","id":"IPR001241","properties":[{"key":"EntryName","value":"Topo_IIA"}]},{"database":"InterPro","id":"IPR013760","properties":[{"key":"EntryName","value":"Topo_IIA-like_dom_sf"}]},{"database":"InterPro","id":"IPR000565","properties":[{"key":"EntryName","value":"Topo_IIA_B"}]},{"database":"InterPro","id":"IPR013759","properties":[{"key":"EntryName","value":"Topo_IIA_B_C"}]},{"database":"InterPro","id":"IPR013506","properties":[{"key":"EntryName","value":"Topo_IIA_bsu_dom2"}]},{"database":"InterPro","id":"IPR018522","properties":[{"key":"EntryName","value":"TopoIIA_CS"}]},{"database":"InterPro","id":"IPR006171","properties":[{"key":"EntryName","value":"TOPRIM_dom"}]},{"database":"PANTHER","id":"PTHR45866:SF1","properties":[{"key":"EntryName","value":"DNA GYRASE SUBUNIT B, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45866","properties":[{"key":"EntryName","value":"DNA GYRASE/TOPOISOMERASE SUBUNIT B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00204","properties":[{"key":"EntryName","value":"DNA_gyraseB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01751","properties":[{"key":"EntryName","value":"Toprim"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01159","properties":[{"key":"EntryName","value":"DNAGYRASEB"}]},{"database":"PRINTS","id":"PR00418","properties":[{"key":"EntryName","value":"TPI2FAMILY"}]},{"database":"SMART","id":"SM00433","properties":[{"key":"EntryName","value":"TOP2c"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56719","properties":[{"key":"EntryName","value":"Type II DNA topoisomerase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00177","properties":[{"key":"EntryName","value":"TOPOISOMERASE_II"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50880","properties":[{"key":"EntryName","value":"TOPRIM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SGGLHGVGVSVVNALSQKLELVIRREGKIHQQTYVHGVPQAPLAVTGDTEQTGTQVRFWPSHETFTNVTEFEYEILAKRLRELSFLNSGVSIRLVDKRDGKQDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKTAVEQQMNELLAEYLLENPSDAKIVVGKIIDAARAREAARKAREMTRRKGALDLAGLPGKLADCQERDPAHSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIII","length":384,"molWeight":42501,"crc64":"0570CFA6D83DCB1A","md5":"9AD8E5C3345E18D0B85AE4DDF28109D9"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Site":2,"Non-terminal residue":2},"uniParcId":"UPI000299AA54"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"R4J991","uniProtkbId":"R4J991_9ENTR","entryAudit":{"firstPublicDate":"2013-07-24","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2013-07-24","entryVersion":29,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50606.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012461"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"value":"Glucose-1-phosphate thymidylyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012461"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"value":"2.7.7.24"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50606.1"}],"value":"rmlA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"value":"Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTTP + alpha-D-glucose 1-phosphate + H(+) = dTDP-alpha-D-glucose + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15225"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37568"},{"database":"ChEBI","id":"CHEBI:57477"},{"database":"ChEBI","id":"CHEBI:58601"}],"ecNumber":"2.7.7.24","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049336"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005125"}],"value":"Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004781"}],"value":"Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010480"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"value":"Belongs to the glucose-1-phosphate thymidylyltransferase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Nucleotidyl transferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00483"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003706"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"23566272","citationType":"journal article","authors":["Jarvis K.G.","Yan Q.Q.","Grim C.J.","Power K.A.","Franco A.A.","Hu L.","Gopinath G.","Sathyamoorthy V.","Kotewicz M.L.","Kothary M.H.","Lee C.","Sadowski J.","Fanning S.","Tall B.D."],"citationCrossReferences":[{"database":"PubMed","id":"23566272"},{"database":"DOI","id":"10.1089/fpd.2012.1344"}],"title":"Identification and Characterization of Five New Molecular Serogroups of Cronobacter spp.","publicationDate":"2013","journal":"Foodborne Pathog. Dis.","firstPage":"343","lastPage":"352","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50606.1"}],"value":"E609","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50606.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX475926","properties":[{"key":"ProteinId","value":"AGJ50606.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_105537734.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_CP187990.1"}]},{"database":"AlphaFoldDB","id":"R4J991","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0008879","properties":[{"key":"GoTerm","value":"F:glucose-1-phosphate thymidylyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"CDD","id":"cd02538","properties":[{"key":"EntryName","value":"G1P_TT_short"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.550.10:FF:000023","properties":[{"key":"EntryName","value":"Glucose-1-phosphate thymidylyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.550.10","properties":[{"key":"EntryName","value":"Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005907","properties":[{"key":"EntryName","value":"G1P_thy_trans_s"}]},{"database":"InterPro","id":"IPR005835","properties":[{"key":"EntryName","value":"NTP_transferase_dom"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"NCBIfam","id":"NF012024","properties":[{"key":"EntryName","value":"rfbA"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01207","properties":[{"key":"EntryName","value":"rmlA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43532","properties":[{"key":"EntryName","value":"GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43532:SF1","properties":[{"key":"EntryName","value":"GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00483","properties":[{"key":"EntryName","value":"NTP_transferase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFEQLLGDGSQWGLNLQYKVQPSPDGLAQAFIIGEEFIGNDKCALVLGDNIFYGHDLPKQLGHAVSQESGATVFAYHVNDPERYGVVEFDKTGKAISLEEKPTEPKSNYAVTGLYFYDNDVVEMAKSLKPSARGELEITDINRLYLEQGRLAVAMMGRGYAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAFRKGFIDAEQVKKLAEPLKKNAYGQYLLKMIKGY","length":292,"molWeight":32443,"crc64":"38E9407BACBC6928","md5":"C21C43F9FCA724BF6F882074841BCBF7"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":2,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI0003321172"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"R4J9A6","uniProtkbId":"R4J9A6_9ENTR","entryAudit":{"firstPublicDate":"2013-07-24","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2013-07-24","entryVersion":35,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50605.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017099"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"dTDP-4-dehydrorhamnose reductase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012929"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"1.1.1.133"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50605.1"}],"value":"rmlD"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00097277"}],"value":"Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS). Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21796"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57510"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:62830"}],"ecNumber":"1.1.1.133","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048200"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"Binds 1 Mg(2+) ion per monomer."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005125"}],"value":"Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004781"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"value":"Belongs to the dTDP-4-dehydrorhamnose reductase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"RmlD-like substrate binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04321"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364082"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"23566272","citationType":"journal article","authors":["Jarvis K.G.","Yan Q.Q.","Grim C.J.","Power K.A.","Franco A.A.","Hu L.","Gopinath G.","Sathyamoorthy V.","Kotewicz M.L.","Kothary M.H.","Lee C.","Sadowski J.","Fanning S.","Tall B.D."],"citationCrossReferences":[{"database":"PubMed","id":"23566272"},{"database":"DOI","id":"10.1089/fpd.2012.1344"}],"title":"Identification and Characterization of Five New Molecular Serogroups of Cronobacter spp.","publicationDate":"2013","journal":"Foodborne Pathog. Dis.","firstPage":"343","lastPage":"352","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50605.1"}],"value":"E609","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50605.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX475926","properties":[{"key":"ProteinId","value":"AGJ50605.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_282831948.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JASCZX010000018.1"}]},{"database":"AlphaFoldDB","id":"R4J9A6","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00124","properties":[{"key":"RectionId","value":"-"}]},{"database":"UniPathway","id":"UPA00281","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008831","properties":[{"key":"GoTerm","value":"F:dTDP-4-dehydrorhamnose reductase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0019305","properties":[{"key":"GoTerm","value":"P:dTDP-rhamnose biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0009243","properties":[{"key":"GoTerm","value":"P:O antigen biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd05254","properties":[{"key":"EntryName","value":"dTDP_HR_like_SDR_e"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000159","properties":[{"key":"EntryName","value":"dTDP-4-dehydrorhamnose reductase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.25.10","properties":[{"key":"EntryName","value":"UDP-galactose 4-epimerase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR005913","properties":[{"key":"EntryName","value":"RmlD"}]},{"database":"InterPro","id":"IPR029903","properties":[{"key":"EntryName","value":"RmlD-like-bd"}]},{"database":"NCBIfam","id":"NF007440","properties":[{"key":"EntryName","value":"rfbD"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01214","properties":[{"key":"EntryName","value":"rmlD"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10491","properties":[{"key":"EntryName","value":"DTDP-4-DEHYDRORHAMNOSE REDUCTASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10491:SF4","properties":[{"key":"EntryName","value":"METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04321","properties":[{"key":"EntryName","value":"RmlD_sub_bind"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNILLFGKSGQVGWELQRALAPLGHIIALDFNSEDYCGDFSNPEGVAETVRRIKPDVIVNAAAHTAVDKAEAERDFAQLLNATSVEAIAREAAKINAWVIHYSTDYVFPGTGETPWCESDATAPLNVYGETKLAGERAVQNFCPNHLIFRTSWVYAGKGNNFAKTMLRLAKERESLSVINDQYGAPTGAELLADCTAHAIRVALAKPEVAGLYHLVASGVTTWYDFAALVFDEARKAGITLKLTDLQPVPTSAYPTPARRPQNSRLNTLKFQQQFGLVLPQWDMGVKRMLEEWFTGVN","length":298,"molWeight":32802,"crc64":"EE3CABF7C888A336","md5":"A04C14201DBFDC17C309459B01489597"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":2,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI0003321347"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"R4J9C2","uniProtkbId":"R4J9C2_9ENTR","entryAudit":{"firstPublicDate":"2013-07-24","lastAnnotationUpdateDate":"2025-10-08","lastSequenceUpdateDate":"2013-07-24","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50603.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019048"}],"value":"UTP--glucose-1-phosphate uridylyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012415"}],"value":"2.7.7.9"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031455"}],"value":"Alpha-D-glucosyl-1-phosphate uridylyltransferase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031959"}],"value":"UDP-glucose pyrophosphorylase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032341"}],"value":"Uridine diphosphoglucose pyrophosphorylase"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50603.1"}],"value":"galF"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19889"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:46398"},{"database":"ChEBI","id":"CHEBI:58601"},{"database":"ChEBI","id":"CHEBI:58885"}],"ecNumber":"2.7.7.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048128"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006890"}],"value":"Belongs to the UDPGP type 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Nucleotidyl transferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00483"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50603.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"23566272","citationType":"journal article","authors":["Jarvis K.G.","Yan Q.Q.","Grim C.J.","Power K.A.","Franco A.A.","Hu L.","Gopinath G.","Sathyamoorthy V.","Kotewicz M.L.","Kothary M.H.","Lee C.","Sadowski J.","Fanning S.","Tall B.D."],"citationCrossReferences":[{"database":"PubMed","id":"23566272"},{"database":"DOI","id":"10.1089/fpd.2012.1344"}],"title":"Identification and Characterization of Five New Molecular Serogroups of Cronobacter spp.","publicationDate":"2013","journal":"Foodborne Pathog. Dis.","firstPage":"343","lastPage":"352","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50603.1"}],"value":"E609","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50603.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX475926","properties":[{"key":"ProteinId","value":"AGJ50603.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"R4J9C2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003983","properties":[{"key":"GoTerm","value":"F:UTP:glucose-1-phosphate uridylyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006011","properties":[{"key":"GoTerm","value":"P:UDP-alpha-D-glucose metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.90.550.10","properties":[{"key":"EntryName","value":"Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005771","properties":[{"key":"EntryName","value":"GalU_uridylyltTrfase_bac/arc"}]},{"database":"InterPro","id":"IPR005835","properties":[{"key":"EntryName","value":"NTP_transferase_dom"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"PANTHER","id":"PTHR43197","properties":[{"key":"EntryName","value":"UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43197:SF2","properties":[{"key":"EntryName","value":"UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00483","properties":[{"key":"EntryName","value":"NTP_transferase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"ENHFDTSYELEALLEQRVKRQLLAEVQSICPPGVTIMNVRQAQPLGLGHSILCARPIIGDNPFVVVLPDVIIDAASADPLRYNLAAMIARFQENGRSQVLAKRMAGDLSEYSVITTQDALDTEGKISRIVDFIEKPDQPQTLNSDLMAVGRYVLSADVWEELAKTEPGAWGRIQLTDAIARLNENQPVEAMLMTGESYDCGKKMGYMKAFVNYGLRNLKEGQKFRESIKKLLA","length":233,"molWeight":25942,"crc64":"C6222295A3B9611B","md5":"9260E665B21C3161F9A8F899D828E7EB"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI000332252A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"R4J9C5","uniProtkbId":"R4J9C5_9ENTR","entryAudit":{"firstPublicDate":"2013-07-24","lastAnnotationUpdateDate":"2025-06-18","lastSequenceUpdateDate":"2013-07-24","entryVersion":36,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50604.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011990"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"value":"dTDP-glucose 4,6-dehydratase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011990"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"value":"4.2.1.46"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50604.1"}],"value":"rmlB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17221"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:57477"},{"database":"ChEBI","id":"CHEBI:57649"}],"ecNumber":"4.2.1.46","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001539"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"NAD(+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001911"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57540"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008178"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"value":"Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"NAD(P)-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF16363"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004473"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"}],"id":"KW-0520","category":"Ligand","name":"NAD"}],"references":[{"referenceNumber":1,"citation":{"id":"23566272","citationType":"journal article","authors":["Jarvis K.G.","Yan Q.Q.","Grim C.J.","Power K.A.","Franco A.A.","Hu L.","Gopinath G.","Sathyamoorthy V.","Kotewicz M.L.","Kothary M.H.","Lee C.","Sadowski J.","Fanning S.","Tall B.D."],"citationCrossReferences":[{"database":"PubMed","id":"23566272"},{"database":"DOI","id":"10.1089/fpd.2012.1344"}],"title":"Identification and Characterization of Five New Molecular Serogroups of Cronobacter spp.","publicationDate":"2013","journal":"Foodborne Pathog. Dis.","firstPage":"343","lastPage":"352","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50604.1"}],"value":"E609","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AGJ50604.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX475926","properties":[{"key":"ProteinId","value":"AGJ50604.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_282831949.1","properties":[{"key":"NucleotideSequenceId","value":"NZ_JASCZX010000018.1"}]},{"database":"AlphaFoldDB","id":"R4J9C5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0008460","properties":[{"key":"GoTerm","value":"F:dTDP-glucose 4,6-dehydratase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0009225","properties":[{"key":"GoTerm","value":"P:nucleotide-sugar metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd05246","properties":[{"key":"EntryName","value":"dTDP_GD_SDR_e"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000108","properties":[{"key":"EntryName","value":"dTDP-glucose 4,6-dehydratase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.25.10","properties":[{"key":"EntryName","value":"UDP-galactose 4-epimerase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005888","properties":[{"key":"EntryName","value":"dTDP_Gluc_deHydtase"}]},{"database":"InterPro","id":"IPR016040","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"NCBIfam","id":"TIGR01181","properties":[{"key":"EntryName","value":"dTDP_gluc_dehyt"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF007490","properties":[{"key":"EntryName","value":"PRK10084.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43000","properties":[{"key":"EntryName","value":"DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16363","properties":[{"key":"EntryName","value":"GDP_Man_Dehyd"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKILVTGGAGFIGSAVVRHIIDHTQDRVVNLDKLTYAGNPESVSSVAHSERYAFEQVDICDRAALDRVFKEHQPDAVMHLAAESHVDRSISGPADFIETNIVGTYTLLEAARAYWSLLDDQRKAAFRFHHISTDEVYGDLPHPDEWQASEALPLFTEKTAYAPSSPYSASKASSDHLVRAWLRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALDGKPLPVYGKGDQIRDWLYVEDHARALYTVVTQGQVGETYNIGGHNEKKNLDVVLTICALLDEIKPKSTSYREQITYVADRPGHDRRYAIDADKISRELGWQPQETFESGIRKTVQWYLDNSQWVENVKSGAYKSWIEENYGTR","length":360,"molWeight":40632,"crc64":"E92683117B6FED13","md5":"A7D04ADF9A065CA472CE3419C70DD9B3"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI000332426F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F6KPF5","uniProtkbId":"F6KPF5_9ENTR","entryAudit":{"firstPublicDate":"2011-07-27","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2011-07-27","entryVersion":24,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADU60586.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADU60586.1"}],"value":"Truncated replication protein A"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADU60586.1"}],"value":"repA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038283"}],"value":"Belongs to the initiator RepB protein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Initiator Rep protein WH1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01051"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADU60586.1"}],"value":"CTU1","geneEncodingType":"Plasmid"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADU60586.1"}],"id":"KW-0614","category":"Technical term","name":"Plasmid"}],"references":[{"referenceNumber":1,"citation":{"id":"21421789","citationType":"journal article","authors":["Franco A.A.","Hu L.","Grim C.J.","Gopinath G.","Sathyamoorthy V.","Jarvis K.G.","Lee C.","Sadowski J.","Kim J.","Kothary M.H.","McCardell B.A.","Tall B.D."],"citationCrossReferences":[{"database":"PubMed","id":"21421789"},{"database":"DOI","id":"10.1128/AEM.03023-10"}],"title":"Characterization of putative virulence genes on the related RepFIB plasmids harbored by Cronobacter spp.","publicationDate":"2011","journal":"Appl. Environ. Microbiol.","firstPage":"3255","lastPage":"3267","volume":"77"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADU60586.1"}],"value":"E681","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADU60586.1"}],"value":"CTU1","type":"PLASMID"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADU60586.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ536984","properties":[{"key":"ProteinId","value":"ADU60586.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"F6KPF5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003887","properties":[{"key":"GoTerm","value":"F:DNA-directed DNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006270","properties":[{"key":"GoTerm","value":"P:DNA replication initiation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000525","properties":[{"key":"EntryName","value":"Initiator_Rep_WH1"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"Pfam","id":"PF01051","properties":[{"key":"EntryName","value":"Rep3_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MADEESININDAFSELDRKTGEVVTLVPNRNNTVQPVALMRLGLFVPTLKSTARGRKGQMSSMDVTEELKQLSLVKSEGYENIKITGARLDMDNDFKTWVGIIHAFAKYNVLGDSVTLPFVEFVKLCGIPSARSSAKLRKRLDASLTRIATNTISFSNKEGEYYVTHLVQSAKYSAKKDEVTLQADPKIFELYQFDKKVLLQLRAINELSRKESAQALYTFIESLPPNPAPISLARLRARLNLTSRTITQNSTVRKAMEQLKEIGYLDYTEIKRGRVVYFHIHYRRPKLRPQSLPGVLPAGEEYR","length":305,"molWeight":34575,"crc64":"8EF7D62B491A15F8","md5":"2A5835836328BD5491ED57A4C77CA873"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI00020D6313"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7D760","uniProtkbId":"I7D760_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2012-10-03","entryVersion":28,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84308.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84308.1"}],"value":"Elg3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84308.1"}],"value":"elg3"}}],"features":[{"type":"Domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"UDP-N-acetylglucosamine 2-epimerase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02350"}]}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84308.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84308.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84308.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7D760","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004553","properties":[{"key":"GoTerm","value":"F:hydrolase activity, hydrolyzing O-glycosyl compounds"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006047","properties":[{"key":"GoTerm","value":"P:UDP-N-acetylglucosamine metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd03786","properties":[{"key":"EntryName","value":"GTB_UDP-GlcNAc_2-Epimerase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2000","properties":[{"key":"EntryName","value":"Glycogen Phosphorylase B"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR020004","properties":[{"key":"EntryName","value":"UDP-GlcNAc_Epase"}]},{"database":"InterPro","id":"IPR003331","properties":[{"key":"EntryName","value":"UDP_GlcNAc_Epimerase_2_dom"}]},{"database":"InterPro","id":"IPR029767","properties":[{"key":"EntryName","value":"WecB-like"}]},{"database":"NCBIfam","id":"TIGR03568","properties":[{"key":"EntryName","value":"NeuC_NnaA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43174","properties":[{"key":"EntryName","value":"UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43174:SF3","properties":[{"key":"EntryName","value":"UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02350","properties":[{"key":"EntryName","value":"Epimerase_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53756","properties":[{"key":"EntryName","value":"UDP-Glycosyltransferase/glycogen phosphorylase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPKKIAVFTGTRAEYGLLYWLMKDIQNEPSLQLQILVSGMHLSPEFGLTWQQIEKDGFKIDEKVEILLSSDSAVGVLKSMGLGLIGYSDALSRMQPQLLIILGDRYEAFAAAQAAMFLRIPVFHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEEYRNRVIQLGEEPERVFNVGALGLEHIKRTKMLSREELSNSLGFNLQAPYFLITYHPVTLADEPPEASFTALLDALQEFFPYKIILTYPNSDDGGRKIIPLLERYAADNRDRVFAIPSLGQLRYMSALAHCSMVIGNSSSGIIEAPSFGIPTVNIGARQKGRLAADSVINCLPAKKDIVRAITDALHLSKKLCKTSVINPYGQGDSSKKIINAIKSMHFKPMKKFYDLG","length":384,"molWeight":42623,"crc64":"407E6A6709DB7E55","md5":"04C098A09ECF9144F6339FF92F62BB1C"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI000274E207"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7D763","uniProtkbId":"I7D763_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2025-06-18","lastSequenceUpdateDate":"2012-10-03","entryVersion":25,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84313.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049738"}],"value":"Putative O-antigen transporter"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84313.1"}],"value":"wzx"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84313.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84313.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84313.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7D763","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR050833","properties":[{"key":"EntryName","value":"Poly_Biosynth_Transport"}]},{"database":"InterPro","id":"IPR002797","properties":[{"key":"EntryName","value":"Polysacc_synth"}]},{"database":"PANTHER","id":"PTHR30250:SF11","properties":[{"key":"EntryName","value":"O-ANTIGEN TRANSPORTER-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30250","properties":[{"key":"EntryName","value":"PST FAMILY PREDICTED COLANIC ACID TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01943","properties":[{"key":"EntryName","value":"Polysacc_synt"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSLLKKSSIYLISNIINASIPFVLLPILTRYLSASQYGQVAIFQTVITGLVSVIAFNTLGAMARAYFDDKDEVYLRNYNGACILLLLVSLLIIGLVTILFSSQLIHFLGLNRKWLVLAIGIAAINFIVQFRLNQWQIKEKAIHFGLLQIGQSLLLFLFSVWFVVFLLMGADGRVEAHFYSMLIVFMITVFLIYKDKLVSFSNLRKEMFADALSFGIPLIPHVFGMYLLSSVDRFFINAELGSGKAGIYMVAMQLSMGFVIIFDAINKAFMPWLFRELNSSHYTERKGIARKTYLYFLILTVVGVLSFLIAPYVLTFVAGPEYHEGQVVIGWLCLGQVFLGMYLMVTNYIFYAKKTGQLSLLTILCGAFNVALLLILIKPYGIEGVAISFAISMFIRFLGTWALAYRTKLVPWF","length":413,"molWeight":46629,"crc64":"AA85B534B3A6610B","md5":"5A33941B1650773E5FB8895661B3C3AD"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":12},"uniParcId":"UPI000274E20C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7DGU9","uniProtkbId":"I7DGU9_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2012-10-03","entryVersion":24,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84306.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84306.1"}],"value":"Elg1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84306.1"}],"value":"elg1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007430"}],"value":"Belongs to the polysaccharide synthase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Polysaccharide biosynthesis protein CapD-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02719"}]}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84306.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84306.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84306.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7DGU9","properties":[{"key":"Description","value":"-"}]},{"database":"CDD","id":"cd05237","properties":[{"key":"EntryName","value":"UDP_invert_4-6DH_SDR_e"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR003869","properties":[{"key":"EntryName","value":"Polysac_CapD-like"}]},{"database":"InterPro","id":"IPR051203","properties":[{"key":"EntryName","value":"Polysaccharide_Synthase-Rel"}]},{"database":"PANTHER","id":"PTHR43318:SF1","properties":[{"key":"EntryName","value":"POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43318","properties":[{"key":"EntryName","value":"UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02719","properties":[{"key":"EntryName","value":"Polysacc_synt_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIDILKLIGRNKALFDSDILNNEAELQAKVSNSKFLVLGGAGSIGQAVTKEIFKRNPRKLHVVDISENNLVELVRDIRSSFGYINGDFKTFALDIGSLEYDVFINADGEYDYVLNLSALKHVRSEKDPFTLMRMIDVNIFNTEKTILQSHQHGAKKYFCVSTDKAANPVNMMGGSKRIMEMFLMTQTSNIDISTARFANVAFSDGSLLHGFNQRIQKKQPIVAPNDIKRYFVTPQESGELCLMSCMFGKSGDIFFPKLSEELDLITFSDIAILYLRQLGREPYLCDTEEEAREFAKNNRDSKHWPCLFTPSDTTGEKDFEEFFMDDEVVDMDKYLNIGIVKKTSAYDVDAVEHFRSEIKKMKNKMSWNKDEIVALFHKTIPGFGHQEKGKYLDSKM","length":396,"molWeight":45177,"crc64":"6C95BB6F3FF6BFB8","md5":"060B2FA8D7E3A0325960CBFEDB2F8F06"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI000274E205"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7DGV3","uniProtkbId":"I7DGV3_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2025-10-08","lastSequenceUpdateDate":"2012-10-03","entryVersion":31,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84311.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84311.1"}],"value":"Elg6"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84311.1"}],"value":"elg6"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"CBS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51371"}]},{"type":"Domain","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"CBS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51371"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00703"}],"id":"KW-0129","category":"Domain","name":"CBS domain"}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84311.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84311.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84311.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7DGV3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016779","properties":[{"key":"GoTerm","value":"F:nucleotidyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd04607","properties":[{"key":"EntryName","value":"CBS_pair_NTP_transferase_assoc"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd06426","properties":[{"key":"EntryName","value":"NTP_transferase_like_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.580.10","properties":[{"key":"EntryName","value":"CBS-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.550.10","properties":[{"key":"EntryName","value":"Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000644","properties":[{"key":"EntryName","value":"CBS_dom"}]},{"database":"InterPro","id":"IPR046342","properties":[{"key":"EntryName","value":"CBS_dom_sf"}]},{"database":"InterPro","id":"IPR050486","properties":[{"key":"EntryName","value":"Mannose-1P_guanyltransferase"}]},{"database":"InterPro","id":"IPR005835","properties":[{"key":"EntryName","value":"NTP_transferase_dom"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"PANTHER","id":"PTHR22572","properties":[{"key":"EntryName","value":"SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00571","properties":[{"key":"EntryName","value":"CBS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00483","properties":[{"key":"EntryName","value":"NTP_transferase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00116","properties":[{"key":"EntryName","value":"CBS"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF54631","properties":[{"key":"EntryName","value":"CBS-domain pair"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51371","properties":[{"key":"EntryName","value":"CBS"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MIKQWRKVLISPQETIRNALKIINDEALRIALVVDESEKLLGVLTDGDIRRAIIGNIDLNDEVYKIMNNRPVTAYADTAKAQLFKIMSERSILAIPLIEAASGKVIGLETFESSLNKKKYQNPIFIMAGGFGTRLKPLTDTCPKPMLKVGDKPILETLLKQFVSAGFENIYISTHYMPELISNYFGDGSKWGVKITYVHEADPLGTGGALGLLPADLPELPLIMINGDVLTTLNVEKLLEFHTTEKAIATMCVREYEYQIPYGVVRGNGNLITDMVEKPVQKFFVNAGIYVIEPQIYKNVPPNFKIDMPTLLEQQIKISKRVTMFPIHEYWLDIGRMDDFNRAQQDIQGLF","length":351,"molWeight":39568,"crc64":"52E1D84AC987B0BE","md5":"3D3BE821E8B20833DBA67651561A7394"},"extraAttributes":{"countByFeatureType":{"Domain":2},"uniParcId":"UPI000274E20A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7DGV7","uniProtkbId":"I7DGV7_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2012-10-03","entryVersion":14,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84316.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84316.1"}],"value":"Wzy"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84316.1"}],"value":"wzy"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84316.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84316.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84316.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7DGV7","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MNKIFKAIFFVFTALYLFSLVFDGILLRQITTVLLFIMSLISIAVDKSKFSVGNVVGVLALVLLFAITALISPNDDWKLKVFFVFSGVTFLLFSYALFTLDYKNYFMHFLVIACVIIIVRFLIVQDENLIFYHASRNIVATFVLFPVICCFLFMKKSSSLLALAFLTIFMCFLLKGRTALLLSLVIMCVALYRAFGIKVLTVIILFSSPIFFYLNFNEINESIAAHTNFSEGLKTTRSVIYDEYFSNFSLADFVFGRSFDGMMIINTLNNNPHNSFLLIHSLFGFLPAFFLLLMFFIASLMLFFRYGFIAALLFLLIPIKAMTDSVIFFNILDVFYMLPLMFLFIRYKAESPAVSIVTDYK","length":361,"molWeight":41375,"crc64":"6A9296015EC830C7","md5":"E64F5217B54FA286AE7C240E3BAE42AE"},"extraAttributes":{"countByFeatureType":{"Transmembrane":10},"uniParcId":"UPI000274E212"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7E4Y5","uniProtkbId":"I7E4Y5_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":27,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84310.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84310.1"}],"value":"Elg5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84310.1"}],"value":"elg5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007274"}],"value":"Belongs to the transferase hexapeptide repeat family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"PglD N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF17836"}]},{"type":"Active site","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR620019-1"}]},{"type":"Binding site","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR620019-2"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57288"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR620019-2"}],"ligand":{"name":"acetyl-CoA","id":"ChEBI:CHEBI:57288"}},{"type":"Site","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Increases basicity of active site His","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR620019-1"}]}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84310.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84310.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84310.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7E4Y5","properties":[{"key":"Description","value":"-"}]},{"database":"CDD","id":"cd03360","properties":[{"key":"EntryName","value":"LbH_AT_putative"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.160.10.10","properties":[{"key":"EntryName","value":"Hexapeptide repeat proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR020019","properties":[{"key":"EntryName","value":"AcTrfase_PglD-like"}]},{"database":"InterPro","id":"IPR001451","properties":[{"key":"EntryName","value":"Hexapep"}]},{"database":"InterPro","id":"IPR041561","properties":[{"key":"EntryName","value":"PglD_N"}]},{"database":"InterPro","id":"IPR050179","properties":[{"key":"EntryName","value":"Trans_hexapeptide_repeat"}]},{"database":"InterPro","id":"IPR011004","properties":[{"key":"EntryName","value":"Trimer_LpxA-like_sf"}]},{"database":"NCBIfam","id":"TIGR03570","properties":[{"key":"EntryName","value":"NeuD_NnaD"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43300","properties":[{"key":"EntryName","value":"ACETYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43300:SF7","properties":[{"key":"EntryName","value":"UDP-N-ACETYLBACILLOSAMINE N-ACETYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00132","properties":[{"key":"EntryName","value":"Hexapep"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17836","properties":[{"key":"EntryName","value":"PglD_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51161","properties":[{"key":"EntryName","value":"Trimeric LpxA-like enzymes"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMRVIRSAMTKQIVLIAGGGHASVIADILLRQHYHIEAIVDVCDNLSRRVFHGIPLISDEQFYERYAPGTIKIANGFGFVPGMTIRKKITEKLFSLGYTFETIISHEAVISKYAIIGAGAQILPGAIVQAGVNIDENSIINTRAIIEHDTSIGRNCHIAPGAVICGGVVCGNDVFIGANATVIQNKRIGDRAIIGAAALVRANVSSDTTIY","length":211,"molWeight":22614,"crc64":"2E501059C07AA2C5","md5":"331D0CFC2767C0CEF4C069B2AE0E437F"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Active site":1,"Binding site":2,"Site":1},"uniParcId":"UPI000274E209"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7E4Y9","uniProtkbId":"I7E4Y9_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":22,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84315.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84315.1"}],"value":"WepB"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84315.1"}],"value":"wepB"}}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84315.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84315.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84315.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7E4Y9","properties":[{"key":"Description","value":"-"}]},{"database":"CDD","id":"cd03801","properties":[{"key":"EntryName","value":"GT4_PimA-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2000","properties":[{"key":"EntryName","value":"Glycogen Phosphorylase B"},{"key":"MatchStatus","value":"2"}]},{"database":"PANTHER","id":"PTHR12526","properties":[{"key":"EntryName","value":"GLYCOSYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13692","properties":[{"key":"EntryName","value":"Glyco_trans_1_4"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53756","properties":[{"key":"EntryName","value":"UDP-Glycosyltransferase/glycogen phosphorylase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNKAVVIHPLDDSYGATKILAYVIAALTRNYKIEVWYKSNKEFLERFLAAQNFTQENITYRLVPSIPVVHSQIFNIKGMLGLLKELVAFTFIVLKMKRSIGFVYINTYAAGLASFICKLCSVKNIIHCHENQKHKISGRALAYLIRKSADKIICVSKVVRNYVCGTSKNTPAVVIMNGITDIFSEVIDDKKIERHNPRFLIVGRIMPEKGYWFLADAIKRLNKDIGSITFSVDAYGDAPPNRPTLVDEYQEYLKSNKLDNDIKLLGFSQQADREMFNYDVVLVPSIMSDPFPTTVLEAMRAKCLVVTTSHGGAAEIITDGVNGILIQKDDTCMFARILRSIAQGDIDIASLASNARLYYEENLTQSAFEKNIVNCFDSFTKEHIDE","length":386,"molWeight":43523,"crc64":"BCD63F78CEF487CB","md5":"0D8E9EC6529E8F54605854CEE85AC541"},"extraAttributes":{"uniParcId":"UPI000274E211"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7EEI9","uniProtkbId":"I7EEI9_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2012-10-03","entryVersion":25,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84309.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84309.1"}],"value":"Elg4"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84309.1"}],"value":"elg4"}}],"features":[{"type":"Domain","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"AFP-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50844"}]}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84309.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84309.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84309.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7EEI9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0047444","properties":[{"key":"GoTerm","value":"F:N-acylneuraminate-9-phosphate synthase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016051","properties":[{"key":"GoTerm","value":"P:carbohydrate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd11615","properties":[{"key":"EntryName","value":"SAF_NeuB_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1210.10","properties":[{"key":"EntryName","value":"Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036732","properties":[{"key":"EntryName","value":"AFP_Neu5c_C_sf"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR020007","properties":[{"key":"EntryName","value":"NeuB/NeuA"}]},{"database":"InterPro","id":"IPR051690","properties":[{"key":"EntryName","value":"PseI-like"}]},{"database":"InterPro","id":"IPR013132","properties":[{"key":"EntryName","value":"PseI/NeuA/B-like_N"}]},{"database":"InterPro","id":"IPR013974","properties":[{"key":"EntryName","value":"SAF"}]},{"database":"InterPro","id":"IPR006190","properties":[{"key":"EntryName","value":"SAF_AFP_Neu5Ac"}]},{"database":"InterPro","id":"IPR057736","properties":[{"key":"EntryName","value":"SAF_PseI/NeuA/NeuB"}]},{"database":"NCBIfam","id":"TIGR03569","properties":[{"key":"EntryName","value":"NeuB_NnaB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42966","properties":[{"key":"EntryName","value":"N-ACETYLNEURAMINATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42966:SF1","properties":[{"key":"EntryName","value":"SIALIC ACID SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03102","properties":[{"key":"EntryName","value":"NeuB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08666","properties":[{"key":"EntryName","value":"SAF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51269","properties":[{"key":"EntryName","value":"AFP III-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51569","properties":[{"key":"EntryName","value":"Aldolase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50844","properties":[{"key":"EntryName","value":"AFP_LIKE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTLIIAEAGVNHNGQRDLAFKLVDAAHQAGADIVKFQTFKSKNLVTKHAAQAEYQITNTNKTESQLAMLSRLELSYETHRELIDYCNELGIEFLSTAFDEESLNFLVSDLGLKKLKVPSGELTNAPFVLAHALTGCDIMLSTGMASLAEIEDALGVIAFGYTTTGDVTPSKAEFEKAYASEAGQEALKSKVRILHCTTEYPAPMKEINLRAMDAISVAFGLPTGYSDHSEGISIPVAAVARGAVIIEKHFTLDKNMEGPDHKASLEPDELAEMIRSIRNVELALGDGVKRPTPSEQKNKNIARRSIVAATNISKGSVFSKDNLAIKRPGDGLSPYNYWNLLGKVARKDYDEGDSLSND","length":358,"molWeight":38937,"crc64":"B2E6EBF2D25116B6","md5":"9CF9964D4A76E8F8CB35803898E940A5"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI000274E208"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7EEJ4","uniProtkbId":"I7EEJ4_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":13,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84314.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84314.1"}],"value":"WepA"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84314.1"}],"value":"wepA"}}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84314.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84314.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84314.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7EEJ4","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"3.40.50.11110","properties":[{"key":"EntryName","value":"Sialyltransferase, C-terminal GT-B Rossman nucleotide-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012477","properties":[{"key":"EntryName","value":"Glyco_transf_52"}]},{"database":"Pfam","id":"PF07922","properties":[{"key":"EntryName","value":"Glyco_transf_52"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNKLEKYQLTPVCIVNNVHGLLIYYLYNTQYFFDTLFVVSDGISVDVQKKLKHTIRIPSFSHSPKLLRIILRAIYYQLANFFLKFKKDNKIVYGHDHLFYSQLFIKKAKRFILLEDGLANYSEHDAAKGGKIRKIIFGSSGPFFGWSKQVSSVVLSGIVDIPDKLKNKTTLVDINMRWNELAPQQKQRFINIFSAEPYIALKKVVIFTQPFSEDAMMSEAQKINIYKKIYNHYRQIFQKDEICIKSHPREHTDYSQYFDCVFIKSKIPGQIMILNDRPEILVTIYSSVGYIRDNIKTHIWGTEFDSFLLEKVGYFEGNYTGWTSNE","length":326,"molWeight":38173,"crc64":"44CEB91F32555473","md5":"39ABE196E241900D176707B655A19B4B"},"extraAttributes":{"uniParcId":"UPI000274E20D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7EGV6","uniProtkbId":"I7EGV6_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":42,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84307.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84307.1"}],"value":"Elg2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84307.1"}],"value":"elg2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004508"}],"value":"Belongs to the DegT/DnrJ/EryC1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Active site","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000390-1"}]},{"type":"Modified residue","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000390-2"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022898"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000390-2"}],"id":"KW-0663","category":"Ligand","name":"Pyridoxal phosphate"}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84307.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84307.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84307.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7EGV6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0030170","properties":[{"key":"GoTerm","value":"F:pyridoxal phosphate binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008483","properties":[{"key":"GoTerm","value":"F:transaminase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000271","properties":[{"key":"GoTerm","value":"P:polysaccharide biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00616","properties":[{"key":"EntryName","value":"AHBA_syn"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1150.10","properties":[{"key":"EntryName","value":"Aspartate Aminotransferase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.640.10","properties":[{"key":"EntryName","value":"Type I PLP-dependent aspartate aminotransferase-like (Major domain)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000653","properties":[{"key":"EntryName","value":"DegT/StrS_aminotransferase"}]},{"database":"InterPro","id":"IPR026385","properties":[{"key":"EntryName","value":"LegC-like"}]},{"database":"InterPro","id":"IPR015424","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase"}]},{"database":"InterPro","id":"IPR015421","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_major"}]},{"database":"InterPro","id":"IPR015422","properties":[{"key":"EntryName","value":"PyrdxlP-dep_Trfase_small"}]},{"database":"NCBIfam","id":"TIGR04181","properties":[{"key":"EntryName","value":"NHT_00031"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30244:SF30","properties":[{"key":"EntryName","value":"BLR5990 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30244","properties":[{"key":"EntryName","value":"TRANSAMINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01041","properties":[{"key":"EntryName","value":"DegT_DnrJ_EryC1"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000390","properties":[{"key":"EntryName","value":"PLP_StrS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53383","properties":[{"key":"EntryName","value":"PLP-dependent transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNAESLVGYIRELYETKEFIPLHAPTFSGNEKEYVLNTIETTFVSSVGQYVDEFERKIESYTGSARAVATVNGTAALHAALYLAGVQRGDLIITQALTFVATCNAIYHLGAEPVFIDISSDSLGLCPKAMSAWLDENARRTETGAVHKKTGKVIRAAVPMHTFGHPVDLDELLIVCDKWGITLVEDAAESLGSFYKGKHTGTIGRYGCLSFNGNKIITTGGGGMILCRSEEDGKRSKHVTTTAKQPHPFEFFHDEPGFNYRMPNINAALGCGQIEKLTLFLSQKRKLAEKYKNFFAGSEFKFVSEPKYSSSNYWLNAIICDSKASRDNLLKDMNASGVMVRPVWKLMHRLPMFENYLRDELKISELIEERLINLPSTPIGHL","length":382,"molWeight":42509,"crc64":"50F3BD18D556671E","md5":"203DBD0CC5514693D4C61DAFCCD21823"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Active site":1,"Modified residue":1},"uniParcId":"UPI000274E206"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7EGV9","uniProtkbId":"I7EGV9_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":27,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84312.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84312.1"}],"value":"Lea7"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84312.1"}],"value":"lea7"}}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84312.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84312.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84312.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7EGV9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0008781","properties":[{"key":"GoTerm","value":"F:N-acylneuraminate cytidylyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd02513","properties":[{"key":"EntryName","value":"CMP-NeuAc_Synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.550.10","properties":[{"key":"EntryName","value":"Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050793","properties":[{"key":"EntryName","value":"CMP-NeuNAc_synthase"}]},{"database":"InterPro","id":"IPR003329","properties":[{"key":"EntryName","value":"Cytidylyl_trans"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"PANTHER","id":"PTHR21485","properties":[{"key":"EntryName","value":"HAD SUPERFAMILY MEMBERS CMAS AND KDSC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21485:SF6","properties":[{"key":"EntryName","value":"N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02348","properties":[{"key":"EntryName","value":"CTP_transf_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTGNIAIIPARGGSKRLPGKNIKILNGKPLIQWSIDAALQSELFDRIIVSTDSIDIKNVAEKAGAEVPYLRSAELSSDTANTDDVVKDVVLWLETHGCQISTITILQPTSPLRTASNIIDAFKLMQLKKAKAIISVCPLEHPIQYCNTLPDDLSLAGFINNKNLKRTQDLPQYYRLNGAIYLFKRSYVSSFRDIYSEGTYAYIMSKDQSIDIDEEIDFEFAQLLMAKRTA","length":230,"molWeight":25693,"crc64":"CEB5B8F9ECD31D0F","md5":"D047A64784A4D7D3848C875A29706FAC"},"extraAttributes":{"uniParcId":"UPI000274E20B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I7EGW5","uniProtkbId":"I7EGW5_9ENTR","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":22,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84317.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84317.1"}],"value":"WepC"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84317.1"}],"value":"wepC"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"DUF1972","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF09314"}]},{"type":"Domain","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Glycosyl transferase family 1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00534"}]}],"references":[{"referenceNumber":1,"citation":{"id":"22834466","citationType":"journal article","authors":["Sun Y.","Arbatsky N.P.","Wang M.","Shashkov A.S.","Liu B.","Wang L.","Knirel Y.A."],"citationCrossReferences":[{"database":"PubMed","id":"22834466"},{"database":"DOI","id":"10.1111/j.1574-695X.2012.01013.x"}],"title":"Structure and genetics of the O-antigen of Cronobacter turicensis G3882 from a new serotype, C. turicensis O2, and identification of a serotype-specific gene.","publicationDate":"2012","journal":"FEMS Immunol. Med. Microbiol.","firstPage":"323","lastPage":"333","volume":"66"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84317.1"}],"value":"G3882","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFO84317.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JQ354993","properties":[{"key":"ProteinId","value":"AFO84317.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I7EGW5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016757","properties":[{"key":"GoTerm","value":"F:glycosyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.2000","properties":[{"key":"EntryName","value":"Glycogen Phosphorylase B"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR015393","properties":[{"key":"EntryName","value":"DUF1972"}]},{"database":"InterPro","id":"IPR001296","properties":[{"key":"EntryName","value":"Glyco_trans_1"}]},{"database":"PANTHER","id":"PTHR46401:SF8","properties":[{"key":"EntryName","value":"BLL6006 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46401","properties":[{"key":"EntryName","value":"GLYCOSYLTRANSFERASE WBBK-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09314","properties":[{"key":"EntryName","value":"DUF1972"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00534","properties":[{"key":"EntryName","value":"Glycos_transf_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53756","properties":[{"key":"EntryName","value":"UDP-Glycosyltransferase/glycogen phosphorylase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKKVSVIGIVGIPASYGGFESLVENLTRFSSEDIHYDVYCSSKQLPTKLHNHNGAELRYVPLKANGIQSILYDIVSILRTLRHKPNVMLVLGVSGAIAIPLFKIFSRSKVITNIDGLEWKREKWGRFARAFLKFSEALAVKYSDVIITDNQAISDYVAIEYGRKSEVIAYGGDHALTHENITDVKNEEPYFLTVCRIEPENNIHLILDSFAKSKKHIKFVGNWSSNEYGRELLRKYDNISNVELINPIYDINELYKLRMNCFGYIHGHSAGGTNPSLVEAMHFEKPIYAFDCKFNRFTTEDKAFYFDSSDSLIQLLNNSNLDTTANAVCMKEIAKRRYTWEIIARQYEHLY","length":351,"molWeight":40236,"crc64":"DC0D6914C85B984F","md5":"EF667D82556C1856D51DF787199E2E59"},"extraAttributes":{"countByFeatureType":{"Domain":2},"uniParcId":"UPI000274E213"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"J9Z405","uniProtkbId":"J9Z405_9ENTR","entryAudit":{"firstPublicDate":"2012-11-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-11-28","entryVersion":32,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Cronobacter turicensis","taxonId":413502,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFS50092.1"}],"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Cronobacter"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFS50092.1"}],"value":"Alpha-1,6-glucosidase"}}],"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008061"}],"value":"Belongs to the glycosyl hydrolase 13 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Glycosyl hydrolase family 13 catalytic","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00642"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFS50092.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFS50092.1"}]}],"references":[{"referenceNumber":1,"citation":{"id":"22941079","citationType":"journal article","authors":["Pava-Ripoll M.","Pearson R.E.","Miller A.K.","Ziobro G.C."],"citationCrossReferences":[{"database":"PubMed","id":"22941079"},{"database":"DOI","id":"10.1128/AEM.02195-12"}],"title":"Prevalence and Relative Risk of Cronobacter spp., Salmonella spp., and Listeria monocytogenes Associated with the Body Surfaces and Guts of Individual Filth Flies.","publicationDate":"2012","journal":"Appl. Environ. Microbiol.","firstPage":"7891","lastPage":"7902","volume":"78"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFS50092.1"}],"value":"Sh41s","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AFS50092.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JX315549","properties":[{"key":"ProteinId","value":"AFS50092.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"J9Z405","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004556","properties":[{"key":"GoTerm","value":"F:alpha-amylase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0009313","properties":[{"key":"GoTerm","value":"P:oligosaccharide catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd11333","properties":[{"key":"EntryName","value":"AmyAc_SI_OligoGlu_DGase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.80:FF:000064","properties":[{"key":"EntryName","value":"Oligo-1,6-glucosidase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.400.10:FF:000002","properties":[{"key":"EntryName","value":"Sucrose isomerase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.80","properties":[{"key":"EntryName","value":"Glycosidases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1180","properties":[{"key":"EntryName","value":"Golgi alpha-mannosidase II"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.400.10","properties":[{"key":"EntryName","value":"Oligo-1,6-glucosidase, Domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006047","properties":[{"key":"EntryName","value":"GH13_cat_dom"}]},{"database":"InterPro","id":"IPR017853","properties":[{"key":"EntryName","value":"GH_hydrolase_sf"}]},{"database":"InterPro","id":"IPR013780","properties":[{"key":"EntryName","value":"Glyco_hydro_b"}]},{"database":"InterPro","id":"IPR032091","properties":[{"key":"EntryName","value":"Malt_amylase-like_C"}]},{"database":"InterPro","id":"IPR045857","properties":[{"key":"EntryName","value":"O16G_dom_2"}]},{"database":"NCBIfam","id":"NF008183","properties":[{"key":"EntryName","value":"PRK10933.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10357","properties":[{"key":"EntryName","value":"ALPHA-AMYLASE FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10357:SF179","properties":[{"key":"EntryName","value":"NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00128","properties":[{"key":"EntryName","value":"Alpha-amylase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16657","properties":[{"key":"EntryName","value":"Malt_amylase_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00642","properties":[{"key":"EntryName","value":"Aamy"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51445","properties":[{"key":"EntryName","value":"(Trans)glycosidases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51011","properties":[{"key":"EntryName","value":"Glycosyl hydrolase domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SFMDANGDGVGDLAGIISKLDYLQQLGINLIWLSPVYKSPMDDNGYDISDYDDIAAEFGTMAEMEQLIQEAKARDIYILMDLVVNHTSDEHPWFIEAKKGKDNPYRDFYIWRKPAPDGGPPNDYRSHFGGSGWAYDEASGEYYLHQFSVRQPDLNWENPRVQEEIHAMMNRWLDKGIGGFRMDVIDLIGKEVDRQIMANGKHLHVLLRQMHDATFGPRDSLTVGEAWSATPEDALLYSDPERRELSMVFQFEHIKQTWDEKAGKWRSRPFELPRFKAVIDKWQTALADRGWNSLFWSNHDLPRAVSKFGHDGEFREVSAKMLATALHCLRGTPYIYQGEEIGMTNVRYSTIEEYRDIESLNFYRELIAGGLTHDEMMTGIYANGRDNARTPMQWNDSPNGGFTTGMPWLGVNPNYREINVAQALAEPDSILWHYQKLVALRKQYPILVYGDYQMLFAEHPEVFAWVRRYEGDTLLVINNFFGNAITLPIPEAMQAWHGECLISNYAPRDQ","length":510,"molWeight":58749,"crc64":"56524F93848AA09B","md5":"D3B9B0B8BA49BB45729DFC3FA0148C85"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0002870C6C"}}]}