{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A076VJJ2","uniProtkbId":"A0A076VJJ2_9TELE","entryAudit":{"firstPublicDate":"2014-10-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2014-10-29","entryVersion":35,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Sebastes viviparus","commonName":"Norway redfish","taxonId":394708,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIK28700.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Neoteleostei","Acanthomorphata","Eupercaria","Perciformes","Scorpaenoidei","Sebastidae","Sebastinae","Sebastes"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013487"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"value":"Rhodopsin"}},"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095979"}],"value":"Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G proteins. Subsequent receptor phosphorylation mediates displacement of the bound G protein alpha subunit by arrestin and terminates signaling"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004504"}],"value":"Cell projection, cilium, photoreceptor outer segment","id":"SL-0458"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"value":"Belongs to the G protein-coupled receptor 1 family. Opsin subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}]},{"type":"Transmembrane","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}]},{"type":"Transmembrane","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}]},{"type":"Transmembrane","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}]},{"type":"Transmembrane","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}]},{"type":"Domain","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Binding site","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600732-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600732-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Site","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Plays an important role in the conformation switch to the active conformation","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600732-2"}]},{"type":"Disulfide bond","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600732-3"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIK28700.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIK28700.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022991"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"id":"KW-0157","category":"Ligand","name":"Chromophore"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600732-3"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600732-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022543"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"id":"KW-0600","category":"Molecular function","name":"Photoreceptor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022925"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"id":"KW-0681","category":"Molecular function","name":"Retinal protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022606"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"id":"KW-0716","category":"Biological process","name":"Sensory transduction"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004951"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023305"}],"id":"KW-0844","category":"Biological process","name":"Vision"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR600732-1"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"25165634","citationType":"journal article","authors":["Shum P.","Pampoulie C.","Sacchi C.","Mariani S."],"citationCrossReferences":[{"database":"PubMed","id":"25165634"}],"title":"Divergence by depth in an oceanic fish.","publicationDate":"2014","journal":"PeerJ","firstPage":"E525","lastPage":"E525","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIK28700.1"}],"value":"1","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIK28706.1"}],"value":"2","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIK28701.1"}],"value":"7","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIK28702.1"}],"value":"9","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AIK28700.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KM013921","properties":[{"key":"ProteinId","value":"AIK28700.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KM013922","properties":[{"key":"ProteinId","value":"AIK28701.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KM013923","properties":[{"key":"ProteinId","value":"AIK28702.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KM013927","properties":[{"key":"ProteinId","value":"AIK28706.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A076VJJ2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001750","properties":[{"key":"GoTerm","value":"C:photoreceptor outer segment"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004930","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007602","properties":[{"key":"GoTerm","value":"P:phototransduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007601","properties":[{"key":"GoTerm","value":"P:visual perception"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000018","properties":[{"key":"EntryName","value":"Rhodopsin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050125","properties":[{"key":"EntryName","value":"GPCR_opsins"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"InterPro","id":"IPR001760","properties":[{"key":"EntryName","value":"Opsin"}]},{"database":"InterPro","id":"IPR000732","properties":[{"key":"EntryName","value":"Rhodopsin"}]},{"database":"PANTHER","id":"PTHR24240","properties":[{"key":"EntryName","value":"OPSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"PRINTS","id":"PR00238","properties":[{"key":"EntryName","value":"OPSIN"}]},{"database":"PRINTS","id":"PR00579","properties":[{"key":"EntryName","value":"RHODOPSIN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"FLLILLGFPINFLTLYVTLEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATIGGEIALWSLVVLAVERWMVVCKPISGFRFTEDHAIMGLGLTWLMACACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFVCHFSIPLTIIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIAFLVCWCPYASVAWFIFLNQGSEFGPVFMTIPA","length":248,"molWeight":27922,"crc64":"21C7A71A5FB66417","md5":"D6BA928B2E193E87FD6DEFFCE4872896"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":5,"Domain":1,"Binding site":2,"Site":1,"Disulfide bond":1,"Non-terminal residue":2},"uniParcId":"UPI0004EF6264"}}]}