{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GCA6","uniProtkbId":"G3GCA6_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":40,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62951.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"dTTP/UTP pyrophosphatase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"dTTPase/UTPase"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"3.6.1.9"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"Nucleoside triphosphate pyrophosphatase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"Nucleotide pyrophosphatase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"Nucleotide PPase"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62951.1"}],"value":"maf"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"UTP + H2O = UMP + diphosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29395"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:46398"},{"database":"ChEBI","id":"CHEBI:57865"}],"ecNumber":"3.6.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dTTP + H2O = dTMP + diphosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:28534"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37568"},{"database":"ChEBI","id":"CHEBI:63528"}],"ecNumber":"3.6.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"a divalent metal cation","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001968"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:60240"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"Belongs to the Maf family. YhdE subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Active site","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}]},{"type":"Site","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"Important for substrate specificity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}]},{"type":"Site","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Important for substrate specificity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}]},{"type":"Site","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Important for substrate specificity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_00528"}],"id":"KW-0546","category":"Biological process","name":"Nucleotide metabolism"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-EK1I8MJR6CTDG","citationType":"submission","authors":["You Y.","Hilpert M.","Ward M.J."],"title":"Characterization of Two Transferrable Tetracycline Resistance Genes Identified in Chicken-Waste-Impacted Soil.","publicationDate":"APR-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62946.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62946.1"}]},{"referenceNumber":2,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62951.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62951.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF837330","properties":[{"key":"ProteinId","value":"AEM62946.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"JF837331","properties":[{"key":"ProteinId","value":"AEM62951.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GCA6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0047429","properties":[{"key":"GoTerm","value":"F:nucleoside triphosphate diphosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"CDD","id":"cd00555","properties":[{"key":"EntryName","value":"Maf"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.950.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00528","properties":[{"key":"EntryName","value":"Maf"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR029001","properties":[{"key":"EntryName","value":"ITPase-like_fam"}]},{"database":"InterPro","id":"IPR003697","properties":[{"key":"EntryName","value":"Maf-like"}]},{"database":"NCBIfam","id":"TIGR00172","properties":[{"key":"EntryName","value":"maf"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43213","properties":[{"key":"EntryName","value":"BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43213:SF5","properties":[{"key":"EntryName","value":"BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02545","properties":[{"key":"EntryName","value":"Maf"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF006305","properties":[{"key":"EntryName","value":"Maf"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52972","properties":[{"key":"EntryName","value":"ITPase-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKFRLSKPVVLASGSPRRKELLELAGIDFEVVKPGVDEPPIAPGEAPHEYAVRLASLKAHAVHGKAPGAAVIGSDTVVYRDSTVYGKPDGEAGARRYLNELSGRTHLVSTGVCILDGETERSFAKDTEVVFRDIPAPLIDAYVQSGDPLDKVGAYGIQSGGALFVREIRGDYHAVVGLPVADVFAALDEMGVILTGEDEP","length":200,"molWeight":21222,"crc64":"A7D037325C635565","md5":"84E2C0841EE119C81133CD83E2CADCB4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Active site":1,"Site":3},"uniParcId":"UPI00021E9D8C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"D5KLY1","uniProtkbId":"D5KLY1_9BACL","entryAudit":{"firstPublicDate":"2010-06-15","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-05-03","entryVersion":53,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADE08372.2"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040630"}],"value":"Tetracycline resistance protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADE08372.2"}],"value":"tet(45)"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003279"}],"value":"Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007520"}],"value":"Belongs to the major facilitator superfamily. TCR/Tet family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":344,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":428,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022449"}],"id":"KW-0050","category":"Biological process","name":"Antiport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-F3GAPN6R7J7K1","citationType":"submission","authors":["You Y.","Hilpert M.","Ward M."],"title":"A new tetracycline resistance protein gene found in a Bacillus sp. isolate from a broiler chicken farm.","publicationDate":"FEB-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADE08372.2"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADE08372.2"}]},{"referenceNumber":2,"citation":{"id":"CI-EK1I8MJR6CTDG","citationType":"submission","authors":["You Y.","Hilpert M.","Ward M.J."],"title":"Characterization of Two Transferrable Tetracycline Resistance Genes Identified in Chicken-Waste-Impacted Soil.","publicationDate":"APR-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62948.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62948.1"}]},{"referenceNumber":3,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62953.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62953.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GU584217","properties":[{"key":"ProteinId","value":"ADE08372.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"JF837330","properties":[{"key":"ProteinId","value":"AEM62948.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"JF837331","properties":[{"key":"ProteinId","value":"AEM62953.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_063855885.1","properties":[{"key":"NucleotideSequenceId","value":"NG_048147.1"}]},{"database":"AlphaFoldDB","id":"D5KLY1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"D5KLY1","properties":[{"key":"Description","value":"-"}]},{"database":"CARD","id":"ARO:3003196","properties":[{"key":"CARD short name","value":"tet(45)"},{"key":"Resistance mechanism identifier","value":"ARO:0010000"},{"key":"Resistance mechanism name","value":"antibiotic efflux"}]},{"database":"KEGG","id":"ag:AEM62953","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0022857","properties":[{"key":"GoTerm","value":"F:transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd17321","properties":[{"key":"EntryName","value":"MFS_MMR_MDR_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1720.10","properties":[{"key":"EntryName","value":"Multidrug resistance protein D"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"NCBIfam","id":"NF012184","properties":[{"key":"EntryName","value":"tet_MFS_45"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF012175","properties":[{"key":"EntryName","value":"tet_MFS_L_K_45"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23501","properties":[{"key":"EntryName","value":"MAJOR FACILITATOR SUPERFAMILY"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23501:SF188","properties":[{"key":"EntryName","value":"TETRACYCLINE RESISTANCE PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01036","properties":[{"key":"EntryName","value":"TCRTETB"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNTPHSHSNLRHNQILLWLCVLSFFSVLNEMVLNVSLPDIASDFNKEPASINWVNSSFILTFSIGTAVYGKLSDQLGIKKLLLFGIIVNCFGSVIGFVGHFFFPVLILARFIQGVGAAAFPALVMVVIARYIPKENRGKAFGIIGSIVTMGEGVGPSVGGVIAEYAHWSYILLLPVVTIITVPFLAKLLKQEEVIKGSFDTKGIIFMSVGIVFFIMFTTCYRVSFLVVSIICFLIFVKNIRKVSNPFINPSLGKNVSFMIGIICGGLIFGTVAGFISMVPYMMKDVYQLSTAAIGSGIIFPGAMSVIVFGYIGGLLVDKKGSLFVLTTGVAFLSISFLVAALFIETTPWLITIILIFVFGGLSFTKTVISTIVSSSLEQKEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIHLLNRKLLPINAEPSTHLYSNLLLLFAGITIISWLVTIKMHKRSRGNI","length":458,"molWeight":49597,"crc64":"539B7C395421A10D","md5":"7CB57E4A8C4BED19D1AB3DEAD8C49B49"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":14,"Domain":1},"uniParcId":"UPI000201C34C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F1JTM4","uniProtkbId":"F1JTM4_9BACL","entryAudit":{"firstPublicDate":"2011-05-03","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-05-03","entryVersion":55,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX42736.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"DNA topoisomerase (ATP-hydrolyzing)"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"5.6.2.2"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX42736.1"}],"value":"gyrB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP-dependent breakage, passage and rejoining of double-stranded DNA.","ecNumber":"5.6.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000185"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010708"}],"value":"Belongs to the type II topoisomerase GyrB family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Toprim","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50880"}]},{"type":"Site","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00995"}]},{"type":"Site","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00995"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX42736.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX42736.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00995"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX42736.1"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023029"}],"id":"KW-0799","category":"Molecular function","name":"Topoisomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"22155760","citationType":"journal article","authors":["Verma P.","Pandey P.K.","Gupta A.K.","Seong C.N.","Park S.C.","Choe H.N.","Baik K.S.","Patole M.S.","Shouche Y.S."],"citationCrossReferences":[{"database":"PubMed","id":"22155760"},{"database":"DOI","id":"10.1099/ijs.0.034850-0"}],"title":"Reclassification of Bacillus beijingensis Qiu et al. 2009 and Bacillus ginsengi Qiu et al. 2009 as Bhargavaea beijingensis comb. nov. and Bhargavaea ginsengi comb. nov. and emended description of the genus Bhargavaea.","publicationDate":"2012","journal":"Int. J. Syst. Evol. Microbiol.","firstPage":"2495","lastPage":"2504","volume":"62"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX42736.1"}],"value":"DSE10","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADX42736.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF261161","properties":[{"key":"ProteinId","value":"ADX42736.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"F1JTM4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0034335","properties":[{"key":"GoTerm","value":"F:DNA negative supercoiling activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006265","properties":[{"key":"GoTerm","value":"P:DNA topological change"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00822","properties":[{"key":"EntryName","value":"TopoII_Trans_DNA_gyrase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.230.10:FF:000005","properties":[{"key":"EntryName","value":"DNA gyrase subunit B"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.230.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.670","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"InterPro","id":"IPR014721","properties":[{"key":"EntryName","value":"Ribsml_uS5_D2-typ_fold_subgr"}]},{"database":"InterPro","id":"IPR001241","properties":[{"key":"EntryName","value":"Topo_IIA"}]},{"database":"InterPro","id":"IPR013760","properties":[{"key":"EntryName","value":"Topo_IIA-like_dom_sf"}]},{"database":"InterPro","id":"IPR000565","properties":[{"key":"EntryName","value":"Topo_IIA_B"}]},{"database":"InterPro","id":"IPR013759","properties":[{"key":"EntryName","value":"Topo_IIA_B_C"}]},{"database":"InterPro","id":"IPR013506","properties":[{"key":"EntryName","value":"Topo_IIA_bsu_dom2"}]},{"database":"InterPro","id":"IPR018522","properties":[{"key":"EntryName","value":"TopoIIA_CS"}]},{"database":"InterPro","id":"IPR006171","properties":[{"key":"EntryName","value":"TOPRIM_dom"}]},{"database":"PANTHER","id":"PTHR45866:SF1","properties":[{"key":"EntryName","value":"DNA GYRASE SUBUNIT B, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45866","properties":[{"key":"EntryName","value":"DNA GYRASE/TOPOISOMERASE SUBUNIT B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00204","properties":[{"key":"EntryName","value":"DNA_gyraseB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01751","properties":[{"key":"EntryName","value":"Toprim"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01159","properties":[{"key":"EntryName","value":"DNAGYRASEB"}]},{"database":"PRINTS","id":"PR00418","properties":[{"key":"EntryName","value":"TPI2FAMILY"}]},{"database":"SMART","id":"SM00433","properties":[{"key":"EntryName","value":"TOP2c"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56719","properties":[{"key":"EntryName","value":"Type II DNA topoisomerase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00177","properties":[{"key":"EntryName","value":"TOPOISOMERASE_II"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50880","properties":[{"key":"EntryName","value":"TOPRIM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"FIAFERGQISEELRVIGDTEETGSEVRFKADPEIFTETTVYEYDILAHRLQELAYLNRGIRITLSDERGEEERSDSYHYEGGIKSYVQHINEDKEPIHEEPIFIEGEKDGISVEIAMQYNAGYASNIFSFANNINTYEGGTHESGFKTALTRVINDYARKSGLLKDNESNLSGEDAREGLTAIVSVKHPDPQFEGQTKTKLGNSEVSQIVNSLFSEGLERFLMENPTGARMIVEKGLMAARARVAAKKARELTRRKSVLEISNLPGKLSDCSSRDPAISELYIVEGDSAGGSAKNGRDRHFQAILPLRGKILNVEKANINRILSNTEIRAMITALGT","length":337,"molWeight":37510,"crc64":"678FEEC2D75C4911","md5":"55F78D9E4950DC24DF882EA242BEB0FF"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Site":2,"Non-terminal residue":2},"uniParcId":"UPI0001FFCEA1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G9G1F7","uniProtkbId":"G9G1F7_9BACL","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2012-05-16","entryVersion":51,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEV41265.2"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040630"}],"value":"Tetracycline resistance protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEV41265.2"}],"value":"tetL"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEV41265.2"}],"value":"pBSDMV46A_p3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003279"}],"value":"Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007520"}],"value":"Belongs to the major facilitator superfamily. TCR/Tet family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEV41265.2"}],"value":"pBSDMV46A","geneEncodingType":"Plasmid"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023251"}],"id":"KW-0046","category":"Biological process","name":"Antibiotic resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022449"}],"id":"KW-0050","category":"Biological process","name":"Antiport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEV41265.2"}],"id":"KW-0614","category":"Technical term","name":"Plasmid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"22389375","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"22389375"},{"database":"DOI","id":"10.1128/AEM.07763-11"}],"title":"Detection of a Common and Persistent tet(L)-Carrying Plasmid in Chicken-Waste-Impacted Farm Soil.","publicationDate":"2012","journal":"Appl. Environ. Microbiol.","firstPage":"3203","lastPage":"3213","volume":"78"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEV41265.2"}],"value":"DMV46A","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEV41265.2"}],"value":"pBSDMV46A","type":"PLASMID"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEV41265.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN980138","properties":[{"key":"ProteinId","value":"AEV41265.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_012477450.1","properties":[{"key":"NucleotideSequenceId","value":"NC_019270.1"}]},{"database":"AlphaFoldDB","id":"G9G1F7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0022857","properties":[{"key":"GoTerm","value":"F:transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd17321","properties":[{"key":"EntryName","value":"MFS_MMR_MDR_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1720.10","properties":[{"key":"EntryName","value":"Multidrug resistance protein D"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"NCBIfam","id":"NF012185","properties":[{"key":"EntryName","value":"tet_MFS_L"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF012175","properties":[{"key":"EntryName","value":"tet_MFS_L_K_45"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23501","properties":[{"key":"EntryName","value":"MAJOR FACILITATOR SUPERFAMILY"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23501:SF188","properties":[{"key":"EntryName","value":"TETRACYCLINE RESISTANCE PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01036","properties":[{"key":"EntryName","value":"TCRTETB"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNTSYSQSNLRHNQILIWLCVLSFFSVLNEMVLNVSLPDIANDFNKSPASTNWVNTAFMLTFSIGTALYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFPILILARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGIGPAIGGMIAHFIHWSYLLLIPMMTIITVPFLIKLLKKEVRIKGHFDIVGIILMSVGIVFFMLFTTSYNISFLIISILSFLIFVKHIRKVTEPFVEPALGKNISFIIGVLCGGLIFGTVAGFISMVPYMMKDVHQLSTAAIGSVIIFPGAMSVIIFGYIGGLLVDRKGPLYVLTIGVTFLSVSFLIAAFFLEVTPWLLTIILVFVFGGLSFTKTVISTIVSSSLKQKEAGAGMSLLNFTSFLSEGIGIAIVGGLLSVRLLNQKLLPMDLDQSTYLYSNMLFLFTGVVVTSWLITLNVYKRRQIQFKS","length":460,"molWeight":50360,"crc64":"EDB39E40043C43E2","md5":"05F94B5869A98B2DCEF56FC97843472C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":14,"Domain":1},"uniParcId":"UPI0000E8CD76"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GCA2","uniProtkbId":"G3GCA2_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-11-16","entryVersion":30,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62947.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62947.1"}],"value":"RadC"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62947.1"}],"value":"radC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010243"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003797"}],"value":"Belongs to the UPF0758 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"UPF0758","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF20582"}]},{"type":"Domain","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"RadC-like JAB","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04002"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023049"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023049"}],"id":"KW-0482","category":"Molecular function","name":"Metalloprotease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023049"}],"id":"KW-0645","category":"Molecular function","name":"Protease"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-EK1I8MJR6CTDG","citationType":"submission","authors":["You Y.","Hilpert M.","Ward M.J."],"title":"Characterization of Two Transferrable Tetracycline Resistance Genes Identified in Chicken-Waste-Impacted Soil.","publicationDate":"APR-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62947.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62947.1"}]},{"referenceNumber":2,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62952.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62952.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF837330","properties":[{"key":"ProteinId","value":"AEM62947.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"JF837331","properties":[{"key":"ProteinId","value":"AEM62952.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GCA2","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"1.10.150.20","properties":[{"key":"EntryName","value":"5' to 3' exonuclease, C-terminal subdomain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.140.10","properties":[{"key":"EntryName","value":"Cytidine Deaminase, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR025657","properties":[{"key":"EntryName","value":"RadC_JAB"}]},{"database":"InterPro","id":"IPR010994","properties":[{"key":"EntryName","value":"RuvA_2-like"}]},{"database":"InterPro","id":"IPR001405","properties":[{"key":"EntryName","value":"UPF0758"}]},{"database":"InterPro","id":"IPR046778","properties":[{"key":"EntryName","value":"UPF0758_N"}]},{"database":"NCBIfam","id":"NF000642","properties":[{"key":"EntryName","value":"radC"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR00608","properties":[{"key":"EntryName","value":"radc"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30471","properties":[{"key":"EntryName","value":"DNA REPAIR PROTEIN RADC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30471:SF3","properties":[{"key":"EntryName","value":"UPF0758 PROTEIN YEES-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04002","properties":[{"key":"EntryName","value":"RadC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20582","properties":[{"key":"EntryName","value":"UPF0758_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47781","properties":[{"key":"EntryName","value":"RuvA domain 2-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTFDLYVPKISELHVADRPRERLIRQGAESLSNQELIAILLRTGTRQESVLQLANRVLAFFDKIQDLQHATLEEITSVKGIGEAKAVQLLAAVELGRRLSRKQSTERYVIRSPEDAAAYLMPDMASLQQENFVVLFLNVKNEVLHSSTIFIGSLNSSIVHPREVFREAVKRSAAAIIFGHIGMKNQWRNYNLLYPQCYINFAFFLMAKLSLKVVMSLLVLSTAGSHLVFTNNKVV","length":235,"molWeight":26546,"crc64":"F2043AF8300EA4E2","md5":"DD8E54EDCD1A404F9D77BDE5C10D4A99"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI00021E9D8D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GCA9","uniProtkbId":"G3GCA9_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":15,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62954.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62954.1"}],"value":"Tet 45 leader peptide"}}]},"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62954.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62954.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF837331","properties":[{"key":"ProteinId","value":"AEM62954.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GCA9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0046677","properties":[{"key":"GoTerm","value":"P:response to antibiotic"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR012618","properties":[{"key":"EntryName","value":"Tet-R_leader_TetL"}]},{"database":"NCBIfam","id":"NF033685","properties":[{"key":"EntryName","value":"Tet_leader_L"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08050","properties":[{"key":"EntryName","value":"Tet_res_leader"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKCNKYNWVHLKRVSVSMTL","length":20,"molWeight":2438,"crc64":"F370EA2BCE721AF1","md5":"FCB610E5A5C1A91B8C90AFD9541E5A1A"},"extraAttributes":{"uniParcId":"UPI00021E9D8F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GCB0","uniProtkbId":"G3GCB0_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":21,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62955.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62955.1"}],"value":"Uncharacterized protein"}}]},"references":[{"referenceNumber":1,"citation":{"id":"CI-EK1I8MJR6CTDG","citationType":"submission","authors":["You Y.","Hilpert M.","Ward M.J."],"title":"Characterization of Two Transferrable Tetracycline Resistance Genes Identified in Chicken-Waste-Impacted Soil.","publicationDate":"APR-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62950.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62950.1"}]},{"referenceNumber":2,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62955.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62955.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF837330","properties":[{"key":"ProteinId","value":"AEM62950.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"JF837331","properties":[{"key":"ProteinId","value":"AEM62955.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GCB0","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR043895","properties":[{"key":"EntryName","value":"DUF5839"}]},{"database":"Pfam","id":"PF19157","properties":[{"key":"EntryName","value":"DUF5839"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNNNTISGFHILGTENGNLKLNTNKMYHWHIQKKLRNTLIAQGDIVLVQTKRGNRPILVMNVFREEDKEKKRKYKRVIKLLEKAPEKSHAVKS","length":93,"molWeight":10894,"crc64":"4B198B60A3F7B17D","md5":"D0B408FBE812785F22F33374B1142E71"},"extraAttributes":{"uniParcId":"UPI00021E9D8E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GCB1","uniProtkbId":"G3GCB1_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-11-16","entryVersion":43,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62956.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62956.1"}],"value":"ArsR"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62956.1"}],"value":"arsR"}}],"features":[{"type":"Domain","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"HTH arsR-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50987"}]},{"type":"DNA binding","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"H-T-H motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00340"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00340"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00340"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00340"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62956.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62956.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF837331","properties":[{"key":"ProteinId","value":"AEM62956.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GCB1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00090","properties":[{"key":"EntryName","value":"HTH_ARSR"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011991","properties":[{"key":"EntryName","value":"ArsR-like_HTH"}]},{"database":"InterPro","id":"IPR001845","properties":[{"key":"EntryName","value":"HTH_ArsR_DNA-bd_dom"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"NCBIfam","id":"NF033788","properties":[{"key":"EntryName","value":"HTH_metalloreg"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33154:SF18","properties":[{"key":"EntryName","value":"ARSENICAL RESISTANCE OPERON REPRESSOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33154","properties":[{"key":"EntryName","value":"TRANSCRIPTIONAL REGULATOR, ARSR FAMILY"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01022","properties":[{"key":"EntryName","value":"HTH_5"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00778","properties":[{"key":"EntryName","value":"HTHARSR"}]},{"database":"SMART","id":"SM00418","properties":[{"key":"EntryName","value":"HTH_ARSR"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50987","properties":[{"key":"EntryName","value":"HTH_ARSR_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIERSDVCDTTLLDYEKKFKALSDHKRLYILRILATEGKTCVCDLSELLALPQSKLSYHLKILLDVKFISVEKEGKWNYYSANPNEIKKILSSDLCCLFYPE","length":102,"molWeight":11852,"crc64":"8A6FD9D38F09414A","md5":"C0591A985A2FDF5C9276C86574352702"},"extraAttributes":{"countByFeatureType":{"Domain":1,"DNA binding":1},"uniParcId":"UPI00021E9D90"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GCB2","uniProtkbId":"G3GCB2_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":14,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62957.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62957.1"}],"value":"Uncharacterized protein"}}]},"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62957.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62957.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF837331","properties":[{"key":"ProteinId","value":"AEM62957.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GCB2","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MIVNHASILSVDYFISYLELIMKARQLSLEEAVFYMKENFFKGEAFLYGEVTAKHFEQAIQLLKRGNFK","length":69,"molWeight":8110,"crc64":"0D556695E74440B2","md5":"4D3D1EFE2D6DF26CCAC8EDE258F754C4"},"extraAttributes":{"uniParcId":"UPI00021E9D91"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GCB3","uniProtkbId":"G3GCB3_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-11-16","entryVersion":20,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62958.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62958.1"}],"value":"TrkA"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62958.1"}],"value":"trkA"}}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62958.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62958.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62958.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF837331","properties":[{"key":"ProteinId","value":"AEM62958.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GCB3","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"3.50.50.60","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050982","properties":[{"key":"EntryName","value":"Auxin_biosynth/cation_transpt"}]},{"database":"InterPro","id":"IPR036188","properties":[{"key":"EntryName","value":"FAD/NAD-bd_sf"}]},{"database":"PANTHER","id":"PTHR43539","properties":[{"key":"EntryName","value":"FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43539:SF78","properties":[{"key":"EntryName","value":"FLAVIN-CONTAINING MONOOXYGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13738","properties":[{"key":"EntryName","value":"Pyr_redox_3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51905","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKEIKLFTIKETSCYGEEPTTTSCCAPETINESTCCSSPEVTVEKPEQKQFNLDLPVAIIGAGPVGLAAAAHLTIQKVPFIVFESGENVGHNILKWQHVQLFSPWQYDIDKAARQLLEETDWESPQDNILPTGKELVDQYLVPLSTLPVLKEAIRYNSKVISISRQQNDKMKSLHREKQPFEIYVERNHEIEIVEARAIIDATGTWGNPNPSTSN","length":215,"molWeight":24163,"crc64":"BFB7B3C947AEE7D6","md5":"4E90EDF4CDF83C89B38C34ADB74BF19E"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI00021E9D92"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHX6","uniProtkbId":"G3GHX6_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":44,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62960.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015313"}],"value":"Copper chaperone CopZ"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62960.1"}],"value":"copA"}}],"features":[{"type":"Domain","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"HMA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50846"}]},{"type":"Non-terminal residue","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62960.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62960.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62960.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62960.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHX6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00371","properties":[{"key":"EntryName","value":"HMA"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.70.100:FF:000005","properties":[{"key":"EntryName","value":"Copper-exporting P-type ATPase A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.100","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR017969","properties":[{"key":"EntryName","value":"Heavy-metal-associated_CS"}]},{"database":"InterPro","id":"IPR006121","properties":[{"key":"EntryName","value":"HMA_dom"}]},{"database":"InterPro","id":"IPR036163","properties":[{"key":"EntryName","value":"HMA_dom_sf"}]},{"database":"PANTHER","id":"PTHR46594","properties":[{"key":"EntryName","value":"P-TYPE CATION-TRANSPORTING ATPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46594:SF4","properties":[{"key":"EntryName","value":"P-TYPE CATION-TRANSPORTING ATPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00403","properties":[{"key":"EntryName","value":"HMA"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00942","properties":[{"key":"EntryName","value":"CUATPASEI"}]},{"database":"SUPFAM","id":"SSF55008","properties":[{"key":"EntryName","value":"HMA, heavy metal-associated domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01047","properties":[{"key":"EntryName","value":"HMA_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50846","properties":[{"key":"EntryName","value":"HMA_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSMSAPSKEASIQISGMTCAACATRIEKGLSKMDGVEQAAVNLALEKSSVKYDPSKMSEAELEKKIESLGYGVVKQKAE","length":80,"molWeight":8487,"crc64":"D4FF314E1E8079E8","md5":"5F8D0D79BADD1CFECA203400CF376E4B"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI00021E9D93"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHX7","uniProtkbId":"G3GHX7_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":36,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62961.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62961.1"}],"value":"CopY"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62961.1"}],"value":"copY"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011046"}],"value":"Belongs to the BlaI transcriptional regulatory family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62961.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62961.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62961.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHX7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005650","properties":[{"key":"EntryName","value":"BlaI_family"}]},{"database":"InterPro","id":"IPR014071","properties":[{"key":"EntryName","value":"Cu_transp_CopY/TcrY"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"NCBIfam","id":"TIGR02698","properties":[{"key":"EntryName","value":"CopY_TcrY"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03965","properties":[{"key":"EntryName","value":"Penicillinase_R"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF019455","properties":[{"key":"EntryName","value":"CopR_AtkY"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSVKTDFNVTDSEWEVMRVVWAHGQASSKEIIDVLGQKMDWKPATTKTFLGRLVNKGMLSTETEGRRYLYSAMVGESEFVRHALDEFFSHVCNREVGRTIEDVLSKATLSHRDIDVLQAILDEKKETAVEEVPCNCIPGQCHCSLHGNDGCGC","length":153,"molWeight":17151,"crc64":"74286DF49C77CA11","md5":"99992E770DE3538960A2BB503B173D73"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"uniParcId":"UPI00021E9D94"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHX8","uniProtkbId":"G3GHX8_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":39,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62979.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62979.1"}],"value":"UvdE"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62979.1"}],"value":"uvdE"}}],"features":[{"type":"Region","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022769"}],"id":"KW-0228","category":"Biological process","name":"DNA excision"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022759"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022722"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62979.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62979.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62979.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHX8","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006289","properties":[{"key":"GoTerm","value":"P:nucleotide-excision repair"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0009411","properties":[{"key":"GoTerm","value":"P:response to UV"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.20.20.150","properties":[{"key":"EntryName","value":"Divalent-metal-dependent TIM barrel enzymes"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004601","properties":[{"key":"EntryName","value":"UvdE"}]},{"database":"InterPro","id":"IPR036237","properties":[{"key":"EntryName","value":"Xyl_isomerase-like_sf"}]},{"database":"NCBIfam","id":"TIGR00629","properties":[{"key":"EntryName","value":"uvde"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31290","properties":[{"key":"EntryName","value":"UV-DAMAGE ENDONUCLEASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31290:SF5","properties":[{"key":"EntryName","value":"UV-DAMAGE ENDONUCLEASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03851","properties":[{"key":"EntryName","value":"UvdE"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51658","properties":[{"key":"EntryName","value":"Xylose isomerase-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDDAGAPGVYSMIKETASGVRSLKVGYACINTSIKEHFRTCRVATVEKKGPEILKELTLENLKLTKRIIEWNIEHGIKFYRMTSEMVVLATHPVNPWDWRNDPDVIQACSEIKMLRDEHGLRLSTHPGQYSVLNSPNPDVVDRTIADLDYHAALSELTGAQDMILHLGGKYGDPEAALGRLVNETRALPEPILKRLRFENDDRTYNLERRPVCQRSDRRTGLLRHPPSPLQPGGRPARKTHQPGVQNMGKHRHAESPHLLRQDRTERPPAPRLHLPRRRRLAARRPRRPQRRHHGRSEGEGTGRARRDRTARGAGDPSGRRILNGSFLAFARQRIRTWLFWKPSWKKHLDDFKNFAKRMMALETSSDLS","length":369,"molWeight":42328,"crc64":"E8342ED571AF8D88","md5":"47F682588ECD6121C39057085BAA2C26"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":4},"uniParcId":"UPI00021E9D95"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHX9","uniProtkbId":"G3GHX9_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-11-16","entryVersion":27,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62962.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62962.1"}],"value":"Fic"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62962.1"}],"value":"fic"}}],"features":[{"type":"Domain","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Fido","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51459"}]},{"type":"Active site","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR640198-1"}]},{"type":"Site","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Important for autoinhibition of adenylyltransferase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR640198-3"}]}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62962.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62962.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62962.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHX9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0070733","properties":[{"key":"GoTerm","value":"F:AMPylase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"Gene3D","id":"1.10.3290.10","properties":[{"key":"EntryName","value":"Fido-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003812","properties":[{"key":"EntryName","value":"Fido"}]},{"database":"InterPro","id":"IPR036597","properties":[{"key":"EntryName","value":"Fido-like_dom_sf"}]},{"database":"InterPro","id":"IPR040198","properties":[{"key":"EntryName","value":"Fido_containing"}]},{"database":"PANTHER","id":"PTHR13504:SF38","properties":[{"key":"EntryName","value":"FIDO DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13504","properties":[{"key":"EntryName","value":"FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02661","properties":[{"key":"EntryName","value":"Fic"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF140931","properties":[{"key":"EntryName","value":"Fic-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51459","properties":[{"key":"EntryName","value":"FIDO"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIRLFETIDTKKARLDAARPLPPYTLKSLQEKLFLEWTYNSNAIEGNTLTLNETKIVLEGITVGGKTLREHLEVINHRDAIMYVEEIVQKKEPLSEWQVKNLHRLVLKGIDDDYAGRYRGEQVFISGAKHIPPAHFLIQEKMERMMDWYHKEGFLLHPVERGAMLHAIFTGIHPFVDGNVPSRHLLRTA","length":189,"molWeight":21892,"crc64":"D38D3A5372EEC5B9","md5":"680862ED0396DDD0B9F4597306928001"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Active site":1,"Site":1},"uniParcId":"UPI00021E9D96"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY0","uniProtkbId":"G3GHY0_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62977.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62977.1"}],"value":"Conjugative transposon protein"}}]},"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62977.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62977.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62977.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY0","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"2.40.50.390","properties":[{"key":"EntryName","value":"Conjugative transposon protein, DUF961"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010365","properties":[{"key":"EntryName","value":"DUF961"}]},{"database":"InterPro","id":"IPR038620","properties":[{"key":"EntryName","value":"YdcP-like_sf"}]},{"database":"Pfam","id":"PF06125","properties":[{"key":"EntryName","value":"DUF961"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MELKFVIPNMEKTFGNLEFAGEDKIVQRRINGQLTILSRSYNLYSDVQRADDIVVVLPAEAGEKHFSFEEKVKLVNPRITAEGYKIGTRGFTNYILEADDMIKE","length":104,"molWeight":11915,"crc64":"7C9CF6AF6ECD9BE9","md5":"3D8128E77C11A9436AC0D7C2D2F99723"},"extraAttributes":{"uniParcId":"UPI000000976C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY1","uniProtkbId":"G3GHY1_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62976.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62976.1"}],"value":"Conjugative transposon protein"}}]},"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62976.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62976.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62976.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY1","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"2.40.50.390","properties":[{"key":"EntryName","value":"Conjugative transposon protein, DUF961"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010365","properties":[{"key":"EntryName","value":"DUF961"}]},{"database":"InterPro","id":"IPR038620","properties":[{"key":"EntryName","value":"YdcP-like_sf"}]},{"database":"Pfam","id":"PF06125","properties":[{"key":"EntryName","value":"DUF961"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRLANGIVLEKDATFGELKFSALRREVRIQNEDGSVSDEIKERTYDLKSKGQGRMIQVSIPASVPLKEFDYNARVELINPVADTVATATFQGADVDWYIKADDIVLTKDSNSFRTQPQPKKEPVIDKQ","length":128,"molWeight":14416,"crc64":"33FEAFA8174A7B13","md5":"0AF090D200D654C9BDE6B61DCFB1108E"},"extraAttributes":{"uniParcId":"UPI000000976D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY2","uniProtkbId":"G3GHY2_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":42,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62975.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62975.1"}],"value":"Conjugative transposon FtsK/SpoIIIE family protein"}}]},"features":[{"type":"Transmembrane","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"FtsK","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50901"}]},{"type":"Binding site","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00289"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00289"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00289"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62975.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62975.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62975.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050206","properties":[{"key":"EntryName","value":"FtsK/SpoIIIE/SftA"}]},{"database":"InterPro","id":"IPR002543","properties":[{"key":"EntryName","value":"FtsK_dom"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR22683:SF47","properties":[{"key":"EntryName","value":"FTSK DOMAIN-CONTAINING PROTEIN YDCQ"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22683","properties":[{"key":"EntryName","value":"SPORULATION PROTEIN RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01580","properties":[{"key":"EntryName","value":"FtsK_SpoIIIE"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50901","properties":[{"key":"EntryName","value":"FTSK"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKQRGKRIRPSDKDLVFHFTIASLLPVFLLVVGLFHVKTIQQINWQDLDLLQVDKIDIPYLVISFSVAILVCLLGAFIFRRYKYDMFKQLQHRQKLAKMILENKWYESEQVKTDGFFKDSTSRTKEKITYFPKMYYRLKDGLISIRVEIMLGKYQDQLLHLEKKLESGLYCELTDKELKDSYVEYTLLYDTIANRLSIDEVQAKDGKLRLMTNVWWEYDKLPHMLIAGGTGGGKTYFILTLIEALLHTNSKLTILDPKNADLADLGSVMGNVYYRKDDMLSCIDRFYDEMMKRSEVMKKMENYKTGENYAYLGLPAHFLIFDEYVAFMEMLGTKENTAVLNKLKQIVMLGRQAGFFLILACQRPDAKYLGDGIRDQFNFRVALGRMSEMGYGMMFGSDVQKDFFLKQIKGRGYVDVGTSVISEFYTPLVPKGHDFLEEIKRLSHSKQDTQATCEAEVAGVD","length":461,"molWeight":53440,"crc64":"49F20D18017F6220","md5":"547D82C700D794A5573C71A3D3EB83E4"},"extraAttributes":{"countByFeatureType":{"Transmembrane":2,"Domain":1,"Binding site":1},"uniParcId":"UPI000000976E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY3","uniProtkbId":"G3GHY3_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":19,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62959.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0008006","source":"Google","id":"ProtNLM"}],"value":"Conjugal transfer protein"}}},"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62959.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62959.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62959.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY3","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MLAGVATATPALNPPYLTGGYKSTGNRQKNSRKSFGYKGFRKFRCMSNEL","length":50,"molWeight":5516,"crc64":"7667F627FDCBB5E0","md5":"027C25DD96246EBA5A6D903551E20681"},"extraAttributes":{"countByFeatureType":{"Region":1},"uniParcId":"UPI0000DA4F08"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY4","uniProtkbId":"G3GHY4_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-11-16","entryVersion":39,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62974.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62974.1"}],"value":"Putative conjugative transposon replication initiation factor"}}]},"features":[{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"HTH cro/C1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50943"}]},{"type":"DNA binding","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"H-T-H motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00257"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00257"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62974.1"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62974.1"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00257"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00257"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62974.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62974.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62974.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"G3GHY4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00093","properties":[{"key":"EntryName","value":"HTH_XRE"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.260.40","properties":[{"key":"EntryName","value":"lambda repressor-like DNA-binding domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001387","properties":[{"key":"EntryName","value":"Cro/C1-type_HTH"}]},{"database":"InterPro","id":"IPR010982","properties":[{"key":"EntryName","value":"Lambda_DNA-bd_dom_sf"}]},{"database":"InterPro","id":"IPR048093","properties":[{"key":"EntryName","value":"MobT"}]},{"database":"InterPro","id":"IPR003491","properties":[{"key":"EntryName","value":"REP-like_C"}]},{"database":"InterPro","id":"IPR040819","properties":[{"key":"EntryName","value":"Rol_Rep_N"}]},{"database":"NCBIfam","id":"NF041493","properties":[{"key":"EntryName","value":"MobT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46558:SF4","properties":[{"key":"EntryName","value":"DNA-BIDING PHAGE PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46558","properties":[{"key":"EntryName","value":"TRACRIPTIONAL REGULATORY PROTEIN-RELATED-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01381","properties":[{"key":"EntryName","value":"HTH_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02486","properties":[{"key":"EntryName","value":"Rep_trans"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18106","properties":[{"key":"EntryName","value":"Rol_Rep_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00530","properties":[{"key":"EntryName","value":"HTH_XRE"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47413","properties":[{"key":"EntryName","value":"lambda repressor-like DNA-binding domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50943","properties":[{"key":"EntryName","value":"HTH_CROC1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIGGISLNEQTWVQHLKEKRLSYGLSQNRLAIATGITRQYLSDIETGKVKPSDELQLALLETLERFNPDAPLEMLFDYVRIRFPTTDVQHVVEDVLRLKLSYMLHEDYGFYSYTEHYALGNIFVLCSHELDKGVLVELKGRGCRQFESYLLAQQRSWYEFFMDALVASGVMKRLDLAINDKTGILNIPILTEKCRQEECISVFRSFKSYRSGELVRKDEKECMGNTLYIGSLQSEVYFCIYEKDYEQYKKNDIPIEDAEVKNRFEIRLKNERAYYAVRDLLAYDNPEHTAFKIINRYIRFVDKDDSKARSDWKLNEEWAWFIGNNRERLKLTTKPEPYSFQRTLNWLSHQVAPTLKVAITLDEINQTQVVKDILDHAKLTDRHKQILKQQSVKEQDVITNKK","length":402,"molWeight":47304,"crc64":"BFE6A80A5E938A5A","md5":"36D4617D5E8F5AB05971A9C47A5C157F"},"extraAttributes":{"countByFeatureType":{"Domain":1,"DNA binding":1},"uniParcId":"UPI0000DA4F09"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY5","uniProtkbId":"G3GHY5_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62973.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62973.1"}],"value":"Conjugative transposon protein"}}]},"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62973.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62973.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62973.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"G3GHY5","properties":[{"key":"Description","value":"-"}]}],"sequence":{"value":"MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLIIAIIAVGLVFNAAGVKDILLELFNRIIGA","length":73,"molWeight":8059,"crc64":"D22EFC19A06F786A","md5":"BCC25291AD1128D1B2B67111987A26BF"},"extraAttributes":{"countByFeatureType":{"Transmembrane":2},"uniParcId":"UPI0000009770"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY6","uniProtkbId":"G3GHY6_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":19,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62972.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62972.1"}],"value":"Conjugative transposon protein"}}]},"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62972.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62972.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62972.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY6","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"1.10.8.560:FF:000001","properties":[{"key":"EntryName","value":"Antirestriction protein ArdA"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.480:FF:000001","properties":[{"key":"EntryName","value":"Antirestriction protein ArdA"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.480","properties":[{"key":"EntryName","value":"Antirestriction protein ArdA, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.8.560","properties":[{"key":"EntryName","value":"Antirestriction protein ArdA, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.1190","properties":[{"key":"EntryName","value":"Antirestriction protein ArdA, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009899","properties":[{"key":"EntryName","value":"ArdA"}]},{"database":"InterPro","id":"IPR041895","properties":[{"key":"EntryName","value":"ArdA_dom1"}]},{"database":"InterPro","id":"IPR041896","properties":[{"key":"EntryName","value":"ArdA_dom2"}]},{"database":"InterPro","id":"IPR041893","properties":[{"key":"EntryName","value":"ArdA_dom3"}]},{"database":"Pfam","id":"PF07275","properties":[{"key":"EntryName","value":"ArdA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKIGLNDEYEEYAIHDYELPFTVDEYTSIGELNRLWEMVSELPEELQSELSALLTHFSSIEELSEHQEDIIIHSDCDDMEDVARYYIEETGALGEVPASLQNYIDYESYGRDLELSGTFISTNHGIFEITH","length":165,"molWeight":19098,"crc64":"1E8FA1AE3E683D95","md5":"2AD171D562FAC118FAAE1500250B3DA6"},"extraAttributes":{"uniParcId":"UPI0000009771"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY7","uniProtkbId":"G3GHY7_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-11-16","entryVersion":19,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62971.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62971.1"}],"value":"Conjugative transposon membrane protein"}}]},"features":[{"type":"Transmembrane","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62971.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62971.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62971.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY7","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR025608","properties":[{"key":"EntryName","value":"TcpE"}]},{"database":"Pfam","id":"PF12648","properties":[{"key":"EntryName","value":"TcpE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKKIRSYTSIWSVEKVLYSINDFRLPFPITFTQMTWFVVSLFAVMILGNVPPLSMIEGAFLKYFGIPVAFTWFMSTKTFDGKKPYGFLKSVIAYALRPKLTYAGKKVTLGRNQPQEAITAVRSEFYGISN","length":130,"molWeight":14858,"crc64":"EA61DECFCC369277","md5":"0E6491656E61EEBF71C90909414BB2FA"},"extraAttributes":{"countByFeatureType":{"Transmembrane":2},"uniParcId":"UPI0000009772"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY8","uniProtkbId":"G3GHY8_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-11-16","entryVersion":31,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62970.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62970.1"}],"value":"Conjugative transposon ATP/GTP-binding protein"}}]},"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62970.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62970.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62970.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY8","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR064211","properties":[{"key":"EntryName","value":"ATP/GTP-like"}]},{"database":"InterPro","id":"IPR016628","properties":[{"key":"EntryName","value":"ATPase_SAG2001_prd"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"NCBIfam","id":"NF052333","properties":[{"key":"EntryName","value":"ATPase_TcpF"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30121:SF6","properties":[{"key":"EntryName","value":"SLR6007 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30121","properties":[{"key":"EntryName","value":"UNCHARACTERIZED PROTEIN YJGR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12846","properties":[{"key":"EntryName","value":"AAA_10"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF015040","properties":[{"key":"EntryName","value":"ATPase_SAG2001_prd"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAYPIKYIENNLVWNKDGECYAYYELVPYNYSFLSPEQKIQVHDSFRQLIAQNRDGKIHALQISTESSIRSAQERSKNEVTGKLKAIAYDKIDQQTDALISMIGENQVDYRFFIGFKLLLNDQEFSMKSLTVEAKNALSDFVYDVNHKLMGDFVSMSNDEILRFQKMEKLLENKISRRFKIRRLNKDDFGYLIEHLYGQTGTAYEDYEYHLSKKKLDNETLIKYYDLIKPTRCLIEEKQRYLKIQQEDETVYVAYFTINSIVGELDFPSSEIFYYQQQQFTFPIDTSMNVEIVANCKALSTVRNKKKELKDLDNHAWQSDNETSSNVAEALDSVNELETNLDQSKESMYKLSYVVRVSANDLDELKRRCNEVKDFYDDLSVKLVRPFGDMLGLHEEFLPASKRYMNDYIQYVTSDFLAGLGFGATQMLGENEGIYVGYSLDTGRNVYLKPALASQGVKGSVTNALASAFVGSLGGGKSFANNLIVYYAVLYGAQAVIVDPKAERGRWKETLPEIAHEINIVNLTSDEKSKGLLDPYVIMKNPKDSESLAIDILTFLTGISSRDSERFPVLRKAIRAVTNSEVRGLLKVIEELRVEGTPTSTSIADHIESFTDYDFAHLLFSDGYVEQSISLEKQLNIIQVVDLVLPDKETSFEEYTTMELLSVAMLIVISTFALDFIHSDRSLFKIVDLDEAWSFLQVAQGKTLSMKLVRAGRAMNAGVYFVTQNTDDLLDEKLKNNLGLKFAFRSTDINEIKKTLAFFGVDPEDENNQKRLRDLENGQCLISDLYGRVGVIQFHPVFEELLHAFDTRPPVRKEV","length":815,"molWeight":93179,"crc64":"E1627A3E311BE82E","md5":"188D5D48890A90D6BAAC3297DE776EC7"},"extraAttributes":{"uniParcId":"UPI0000DA4F0A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHY9","uniProtkbId":"G3GHY9_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-11-16","entryVersion":26,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62969.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62969.1"}],"value":"Conjugative transposon membrane protein"}}]},"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":722,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5052348558"},{"type":"Transmembrane","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":424,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Region","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":515,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":553,"modifier":"EXACT"},"end":{"value":722,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":483,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":496,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":623,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":694,"modifier":"EXACT"},"end":{"value":705,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62969.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62969.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62969.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHY9","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR058112","properties":[{"key":"EntryName","value":"CD3337_EF1877-like"}]},{"database":"InterPro","id":"IPR052231","properties":[{"key":"EntryName","value":"Rho_GEF_signaling-related"}]},{"database":"NCBIfam","id":"NF046089","properties":[{"key":"EntryName","value":"CD3337_EF1877"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45845:SF3","properties":[{"key":"EntryName","value":"PURATROPHIN-1-LIKE, ISOFORM A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45845","properties":[{"key":"EntryName","value":"RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMVQKLKSNWTLKRLNKVAMTVVLSLVIAIFLLAMLGTVVQAAGLVDDTVNVANEYSRYPLENYQLDFYVDNSWGWLPWNWSDGIGKQVMYGLYAITNFIWTISLYVSNATGYLVQEAYSLDFISATADSIGKNMQTLAGVTPSGLSTEGFYVGFLLLLILVLGVYVVYTGLIKRETTKAIHAIVNFVMVFILSASFIAYAPDYIKKINDFSSDISQASLSLGTKIVMPHSDSQGNDSVDLIRDSLFSIQVQQPWLLLQYNSSDIESIGADRVESLLSTSPDSNNGEDREKIVAEEIEDRNNVNMTITKTINRLGTVFFLFVFNIGISIFVFLLTGIMIFSQVLFIIYAMFLPVSFILSMIPSFDGMSKRAIIKLFNTILTRAGITLIITTAFSISTMLYTLSAGYPFFLIAFLQIVTFAGIYFKLSDLMSMFSLQSNDSQSVGSRVMRKPRMLMHAHMHRLQRKLGRSMTALGAGSAIASATGKQGQSGSSGRTQADHTRPDGQEKSTLGKRIGQTIGAVADTKDKIVDSAGNLKEQVKDIPTNARYAVYQGKSKAKENVRDLTSSISQTRADRASGRKEQQEQRRKTIAERRSEMEQVKQKKQPASSVHERPATKQEQSHDGQTAKQSSIQTSRMESQQAKQERPAVKSDSLSLKAERQNRTTQERTVQKPATSTTPADRASQRPVTKERPSTVQRVQSQNLRNRPPIKSATIKKGSKKP","length":722,"molWeight":80237,"crc64":"686882B3E126076D","md5":"0368FC5F377BD1D7F45BB324F86F6359"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":5,"Region":2,"Compositional bias":7},"uniParcId":"UPI0000009774"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G3GHZ0","uniProtkbId":"G3GHZ0_9BACL","entryAudit":{"firstPublicDate":"2011-11-16","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2011-11-16","entryVersion":34,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Bhargavaea cecembensis","taxonId":394098,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62968.1"}],"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Caryophanaceae","Bhargavaea"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62968.1"}],"value":"Putative cell wall hydrolase"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007074"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01284"}],"value":"Belongs to the peptidase C40 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"NlpC/P60","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51935"}]},{"type":"Active site","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01284"}]},{"type":"Active site","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01284"}]},{"type":"Active site","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01284"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01284"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01284"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022807"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01284"}],"id":"KW-0788","category":"Molecular function","name":"Thiol protease"}],"references":[{"referenceNumber":1,"citation":{"id":"23595824","citationType":"journal article","authors":["You Y.","Hilpert M.","Ward M.J."],"citationCrossReferences":[{"database":"PubMed","id":"23595824"},{"database":"DOI","id":"10.1093/jac/dkt127"}],"title":"Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil.","publicationDate":"2013","journal":"J. Antimicrob. Chemother.","firstPage":"1962","lastPage":"1969","volume":"68"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62968.1"}],"value":"DMV42A","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM62968.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF915701","properties":[{"key":"ProteinId","value":"AEM62968.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G3GHZ0","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"C40.007","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0008234","properties":[{"key":"GoTerm","value":"F:cysteine-type peptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd16891","properties":[{"key":"EntryName","value":"CwlT-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.530.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1720.10","properties":[{"key":"EntryName","value":"endopeptidase domain like (from Nostoc punctiforme)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR047194","properties":[{"key":"EntryName","value":"CwlT-like_lysozyme"}]},{"database":"InterPro","id":"IPR023346","properties":[{"key":"EntryName","value":"Lysozyme-like_dom_sf"}]},{"database":"InterPro","id":"IPR000064","properties":[{"key":"EntryName","value":"NLP_P60_dom"}]},{"database":"InterPro","id":"IPR038765","properties":[{"key":"EntryName","value":"Papain-like_cys_pep_sf"}]},{"database":"InterPro","id":"IPR051202","properties":[{"key":"EntryName","value":"Peptidase_C40"}]},{"database":"PANTHER","id":"PTHR47053:SF5","properties":[{"key":"EntryName","value":"BIFUNCTIONAL MURAMIDASE_DL-ENDOPEPTIDASE CWLT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47053","properties":[{"key":"EntryName","value":"MUREIN DD-ENDOPEPTIDASE MEPH-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13702","properties":[{"key":"EntryName","value":"Lysozyme_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00877","properties":[{"key":"EntryName","value":"NLPC_P60"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54001","properties":[{"key":"EntryName","value":"Cysteine proteinases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53955","properties":[{"key":"EntryName","value":"Lysozyme-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51935","properties":[{"key":"EntryName","value":"NLPC_P60"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKLKALVIGGSGLFLMVFSLLLFVAILFSDEQDGGFSNIHYGGVNVSAEVLAHKPMVEKYAREYGIEEYVNVLLAIIQVESGGTAEDVMQSSESLGLPPNSLSTEESIKQGVKYFSELLASRDRLGVDLESVIQSYNYGGGFLGYVANRGNKYTFELAQSFSKEYSDGEKVSYPNPIAIPINGGWRYNYGNMFYVQLVTQYLVTTQFNDNTVQAIMDEALKYEGWKYVYGGASPTTSFDCSGLTQWTYGKAGIKLPRTAQQQYDVTQHIPLSEAKAGDLVFFHSTYNAGSYITHIGIYLGDNRMFHAGDPIGYADLTSSYWQQHLVGAGRIKQ","length":333,"molWeight":36854,"crc64":"4CA80EE8A3ABEF9A","md5":"1C4F647C1DB40AFA8AC7B758B52011B0"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Active site":3},"uniParcId":"UPI0001B2B5F9"}}]}