{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"G9FRD7","uniProtkbId":"HDHA_CLOSR","entryAudit":{"firstPublicDate":"2020-12-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2012-02-22","entryVersion":49,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Clostridium sardiniense","commonName":"Clostridium absonum","taxonId":29369,"lineage":["Bacteria","Bacillati","Bacillota","Clostridia","Eubacteriales","Clostridiaceae","Clostridium"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22198717"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26961171"}],"value":"7alpha-hydroxysteroid dehydrogenase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22198717"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26961171"}],"value":"7alpha-HSDH"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22198717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24810359"}],"value":"1.1.1.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22198717"}],"value":"NADP-dependent 7alpha-hydroxysteroid dehydrogenase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22198717"}],"value":"hdha"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22198717"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24810359"}],"value":"7alpha-hydroxysteroid dehydrogenase that catalyzes the NADP(+)-dependent oxidation of the 7alpha-hydroxy group of 7alpha-hydroxysteroids, such as cholate, chenodeoxycholate, glycochenodeoxycholate and taurochenodeoxycholate, to the corresponding 7-oxosteroids (PubMed:22198717, PubMed:24810359). 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