{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P80440","uniProtkbId":"COX1_ALLMA","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-11-01","entryVersion":120,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Cytochrome c oxidase subunit 1"},"ecNumbers":[{"value":"7.1.1.9"}]},"alternativeNames":[{"fullName":{"value":"Cytochrome c oxidase polypeptide I"}}]},"genes":[{"geneName":{"value":"COX1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"value":"Binds 2 heme A groups non-covalently per subunit."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Cu cation","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:23378"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"value":"Binds a copper B center."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"value":"Energy metabolism; oxidative phosphorylation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"value":"Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the heme-copper respiratory oxidase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"Cytochrome c oxidase subunit 1","featureId":"PRO_0000183279"},{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Binding site","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61715"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Fe(II)-heme a","id":"ChEBI:CHEBI:61715","note":"low-spin"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:23378"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Cu cation","id":"ChEBI:CHEBI:23378","label":"B"}},{"type":"Binding site","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:15379"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00396"}],"ligand":{"name":"O2","id":"ChEBI:CHEBI:15379"}},{"type":"Binding site","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:23378"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Cu cation","id":"ChEBI:CHEBI:23378","label":"B"}},{"type":"Binding site","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:23378"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Cu cation","id":"ChEBI:CHEBI:23378","label":"B"}},{"type":"Binding site","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","note":"ligand shared with subunit 2"}},{"type":"Binding site","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","note":"ligand shared with subunit 2"}},{"type":"Binding site","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:83282"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"heme a3","id":"ChEBI:CHEBI:83282","note":"high-spin"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":383,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:61715"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Fe(II)-heme a","id":"ChEBI:CHEBI:61715","note":"low-spin"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Cross-link","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00401"}]}],"geneLocations":[{"geneEncodingType":"Mitochondrion"}],"keywords":[{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0186","category":"Ligand","name":"Copper"},{"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"id":"KW-0349","category":"Ligand","name":"Heme"},{"id":"KW-0408","category":"Ligand","name":"Iron"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"7490780","citationType":"journal article","authors":["Paquin B.","Forget L.","Roewer I.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"7490780"},{"database":"DOI","id":"10.1007/bf00175824"}],"title":"Molecular phylogeny of Allomyces macrogynus: congruency between nuclear ribosomal RNA- and mitochondrial protein-based trees.","publicationDate":"1995","journal":"J. Mol. Evol.","firstPage":"657","lastPage":"665","volume":"41"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 46923 / Burma 3-35 (35OC)","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 46923 / Burma 3-35 (35OC)","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49234.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63651","properties":[{"key":"EntryName","value":"S63651"}]},{"database":"RefSeq","id":"NP_043733.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"P80440","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P80440","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801856","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp14","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00705","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01663","properties":[{"key":"EntryName","value":"Cyt_c_Oxidase_I"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.210.10:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.210.10","properties":[{"key":"EntryName","value":"Cytochrome c oxidase-like, subunit I domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023616","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_dom"}]},{"database":"InterPro","id":"IPR036927","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_sf"}]},{"database":"InterPro","id":"IPR000883","properties":[{"key":"EntryName","value":"Cyt_C_Oxase_1"}]},{"database":"InterPro","id":"IPR023615","properties":[{"key":"EntryName","value":"Cyt_c_Oxase_su1_BS"}]},{"database":"InterPro","id":"IPR033944","properties":[{"key":"EntryName","value":"Cyt_c_oxase_su1_dom"}]},{"database":"InterPro","id":"IPR014241","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su1_bac"}]},{"database":"NCBIfam","id":"TIGR02891","properties":[{"key":"EntryName","value":"CtaD_CoxA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10422","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10422:SF18","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00115","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01165","properties":[{"key":"EntryName","value":"CYCOXIDASEI"}]},{"database":"SUPFAM","id":"SSF81442","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit I-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50855","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00077","properties":[{"key":"EntryName","value":"COX1_CUB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFQRNTVYRWLFSTNAKDIGTLYLVFSIFAGMIGTAFSVLIRFELAGPGVQYLYGDHQLYNVIITAHAFIMIFFLVMPAMLGGFGNYFVPIMIGAPDMAFPRLNNISFWLLPPSLILLVGSAFVEQGAGTGWTVYPPLSSIGFHSGGSVDLAIFSLHLAGISSMLGSINFITTILNMRAPGMTMHKLPLFVWSILITAILLLLSLPVLAGAITMLLTDRNLNTTFYDPAGGGDPVLYQHLFWFFGHPEVYIIIIPGFGIISQVISTFSRKPIFGYLGMVYAMASIGILGFIVWSHHMYTVGLDVDTRAYFTAATMIIAVPTGIKIFSWLATLYGGNILYRTPAYFALGFLFLFTIGGVTGVMLANASLDVALHDTYYVVAHFHYVLSMGAVFALFAGFYYWIGKITGKQYNEFWGQVHFWTMFIGVNVTFFPMHFLGLNGMPRRIPDYPDAFTQWNVISSFGSIISIVSTIVFLYGLYLTLSQPAVSLANNYWHVPSFFSSTHSLYGDTTQTSSSLEWVLPSPPAFHAFNHLPVQS","length":536,"molWeight":59445,"crc64":"7DE8DF291EAE4091","md5":"B3F7206F809A8F7A223E1A5CD518CAA1"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":2,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":12,"Binding site":12,"Cross-link":1},"uniParcId":"UPI0000127F48"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P50364","uniProtkbId":"ATP6_ALLMA","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":100,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"ATP synthase subunit a"}},"alternativeNames":[{"fullName":{"value":"F-ATPase protein 6"}}]},"genes":[{"geneName":{"value":"ATP6"}}],"comments":[{"texts":[{"value":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane"}],"commentType":"FUNCTION"},{"texts":[{"value":"F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ATPase A chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"ATP synthase subunit a","featureId":"PRO_0000082082"},{"type":"Transmembrane","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"geneLocations":[{"geneEncodingType":"Mitochondrion"}],"keywords":[{"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"7991539","citationType":"journal article","authors":["Paquin B.","Laforest M.-J.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"7991539"},{"database":"DOI","id":"10.1073/pnas.91.25.11807"}],"title":"Interspecific transfer of mitochondrial genes in fungi and creation of a homologous hybrid gene.","publicationDate":"1994","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11807","lastPage":"11810","volume":"91"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 46923 / Burma 3-35 (35OC)","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 46923 / Burma 3-35 (35OC)","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U02039","properties":[{"key":"ProteinId","value":"AAA64932.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49231.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63648","properties":[{"key":"EntryName","value":"S63648"}]},{"database":"RefSeq","id":"NP_043730.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"P50364","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P50364","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801875","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp11","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046933","properties":[{"key":"GoTerm","value":"F:proton-transporting ATP synthase activity, rotational mechanism"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00310","properties":[{"key":"EntryName","value":"ATP-synt_Fo_a_6"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.220:FF:000003","properties":[{"key":"EntryName","value":"ATP synthase subunit a"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.220","properties":[{"key":"EntryName","value":"ATP synthase, F0 complex, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01393","properties":[{"key":"EntryName","value":"ATP_synth_a_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000568","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu"}]},{"database":"InterPro","id":"IPR023011","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu_AS"}]},{"database":"InterPro","id":"IPR045083","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu_bact/mt"}]},{"database":"InterPro","id":"IPR035908","properties":[{"key":"EntryName","value":"F0_ATP_A_sf"}]},{"database":"NCBIfam","id":"TIGR01131","properties":[{"key":"EntryName","value":"ATP_synt_6_or_A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11410","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11410:SF0","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00119","properties":[{"key":"EntryName","value":"ATP-synt_A"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00123","properties":[{"key":"EntryName","value":"ATPASEA"}]},{"database":"SUPFAM","id":"SSF81336","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00449","properties":[{"key":"EntryName","value":"ATPASE_A"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFINLNPLEQFSVYSATSAILGSSSNSLAITSLTNIAILFIIGLLVLTIFQISASSHLIKPTRWNIVLETWVASILGIVKDQIGNDAKNSLIYFPLIFTFFSFVFISNILGMIPYSFTPTSHISVTLGLSIAIMIGVTLIGFSKHQLDFFSLFVPKGTPLALVPLLVLIEFISYSARAFSLALRLTANVSAGHCLFGVISALSVSACIAVSSLLLKGITITLPLAVLVVLYGLELLVALLQSYVFTLLTCSYLADVVNMGDH","length":262,"molWeight":28228,"crc64":"D086B3A57771B5FB","md5":"EC1ED2909140A977C615C2C8D259D96F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":7},"uniParcId":"UPI00001262D9"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q37395","uniProtkbId":"CYB_ALLMA","entryAudit":{"firstPublicDate":"2005-12-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":103,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Cytochrome b"}},"alternativeNames":[{"fullName":{"value":"Complex III subunit 3"}},{"fullName":{"value":"Complex III subunit III"}},{"fullName":{"value":"Cytochrome b-c1 complex subunit 3"}},{"fullName":{"value":"Ubiquinol-cytochrome-c reductase complex cytochrome b subunit"}}]},"genes":[{"geneName":{"value":"cob"},"synonyms":[{"value":"cytB"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"heme b","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:60344"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}],"value":"Binds 2 heme b groups non-covalently."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}],"value":"Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00967"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00968"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}],"value":"The protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"Cytochrome b","featureId":"PRO_0000061733"},{"type":"Transmembrane","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}]},{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}]},{"type":"Transmembrane","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}]},{"type":"Transmembrane","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}]},{"type":"Transmembrane","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}]},{"type":"Transmembrane","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}]},{"type":"Transmembrane","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}]},{"type":"Transmembrane","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00163"}]},{"type":"Binding site","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16389"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00157"}],"ligand":{"name":"a ubiquinone","id":"ChEBI:CHEBI:16389"}}],"geneLocations":[{"geneEncodingType":"Mitochondrion"}],"keywords":[{"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"id":"KW-0349","category":"Ligand","name":"Heme"},{"id":"KW-0408","category":"Ligand","name":"Iron"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49221.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63638","properties":[{"key":"EntryName","value":"S63638"}]},{"database":"RefSeq","id":"NP_043720.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q37395","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q37395","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801884","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp01","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045275","properties":[{"key":"GoTerm","value":"C:respiratory chain complex III"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00290","properties":[{"key":"EntryName","value":"cytochrome_b_C"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.810.10:FF:000002","properties":[{"key":"EntryName","value":"Cytochrome b"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR036150","properties":[{"key":"EntryName","value":"Cyt_b/b6_C_sf"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR030689","properties":[{"key":"EntryName","value":"Cytochrome_b"}]},{"database":"InterPro","id":"IPR048260","properties":[{"key":"EntryName","value":"Cytochrome_b_C_euk/bac"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00032","properties":[{"key":"EntryName","value":"Cytochrom_B_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038885","properties":[{"key":"EntryName","value":"COB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81648","properties":[{"key":"EntryName","value":"a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRFLKSHPVLSLANSFLIDSPLPSNITYLWNFGSLLGLCLVIQIVTGVTLAMHYAPSTSLAFVSVEHIMRDVFYGWLIRYAHANGASFFFICVYIHMARGLYFNSYTKPRVLLWSVGVVIYILMMATAFLGYVLPWGQMSFWGATVITNLLSAIPYIGTALVEFVWGGFSVDNATLNRFFSLHYLLPFILAALVVVHLIALHEHGSNNPLGISSKVDRLPFHPYFTYKDLVGFFVFFLIFFGFVFYQPNLMGHPDNYIPANPLVTPVSIVPEWYFLPFYAILRAIPSKLGGVIGMFGALLILLALPWLETSKVRGAGFRPVMKFFFWLFVVNFFLLMYCGGQHAEEPFITLSRICTAYYFMYFLVIIPVIGHLENLLHRCRD","length":382,"molWeight":43468,"crc64":"A892A1A46A6915FA","md5":"86DB232D39C0CD8352A279860C9404E1"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Chain":1,"Transmembrane":8,"Binding site":5},"uniParcId":"UPI000009883D"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P80439","uniProtkbId":"COX3_ALLMA","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1995-11-01","entryVersion":104,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Cytochrome c oxidase subunit 3"},"ecNumbers":[{"value":"7.1.1.9"}]},"alternativeNames":[{"fullName":{"value":"Cytochrome c oxidase polypeptide III"}}]},"genes":[{"geneName":{"value":"COX3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00420"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00420"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00420"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00420"}],"value":"Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00420"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P00420"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the cytochrome c oxidase subunit 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Cytochrome c oxidase subunit 3","featureId":"PRO_0000183730"},{"type":"Transmembrane","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"geneLocations":[{"geneEncodingType":"Mitochondrion"}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"7490780","citationType":"journal article","authors":["Paquin B.","Forget L.","Roewer I.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"7490780"},{"database":"DOI","id":"10.1007/bf00175824"}],"title":"Molecular phylogeny of Allomyces macrogynus: congruency between nuclear ribosomal RNA- and mitochondrial protein-based trees.","publicationDate":"1995","journal":"J. Mol. Evol.","firstPage":"657","lastPage":"665","volume":"41"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 46923 / Burma 3-35 (35OC)","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 46923 / Burma 3-35 (35OC)","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49226.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63643","properties":[{"key":"EntryName","value":"S63643"}]},{"database":"RefSeq","id":"NP_043725.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"P80439","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P80439","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801893","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp06","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01665","properties":[{"key":"EntryName","value":"Cyt_c_Oxidase_III"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.70:FF:000082","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.80:FF:000002","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.80","properties":[{"key":"EntryName","value":"Cytochrome c oxidase, subunit III, four-helix bundle"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024791","properties":[{"key":"EntryName","value":"Cyt_c/ubiquinol_Oxase_su3"}]},{"database":"InterPro","id":"IPR033945","properties":[{"key":"EntryName","value":"Cyt_c_oxase_su3_dom"}]},{"database":"InterPro","id":"IPR000298","properties":[{"key":"EntryName","value":"Cyt_c_oxidase-like_su3"}]},{"database":"InterPro","id":"IPR035973","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su3-like_sf"}]},{"database":"InterPro","id":"IPR013833","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su3_a-hlx"}]},{"database":"PANTHER","id":"PTHR11403:SF7","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11403","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT III"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00510","properties":[{"key":"EntryName","value":"COX3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81452","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit III-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50253","properties":[{"key":"EntryName","value":"COX3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTKKLINQFKSFQVHPYHLVEPSPWPLGASVACLILTLGGVMKFHGFAAGDIGLPLGLILVLASMLLWWRDVIREATYQGHHTKTVKYGITLGVVLFIVSEILLFFSLFWAFFHSSLAPSVELGSTWPPVGIEPLNPFEVPLLNTIILLTSGCTITVSHAKIISGDRGATILYLILTILLAWMFLGLQWVEYVNAPFTIADSVYGSTFFVATGFHGLHVMIGTIFLTVSLNRILSYHLTSGHHLGYEAAIWYWHVVDVIWLFLYVSVYYWGSNV","length":274,"molWeight":30630,"crc64":"4B2A835ED31386F3","md5":"314AD0F72171045C693BF474371FC7DB"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":7},"uniParcId":"UPI000012809E"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P50365","uniProtkbId":"NU5M_ALLMA","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1996-10-01","entryVersion":86,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"NADH-ubiquinone oxidoreductase chain 5"},"ecNumbers":[{"value":"7.1.1.2"}]},"alternativeNames":[{"fullName":{"value":"NADH dehydrogenase subunit 5"}}]},"genes":[{"geneName":{"value":"ND5"},"synonyms":[{"value":"NAD5"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2"}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the complex I subunit 5 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"NADH-ubiquinone oxidoreductase chain 5","featureId":"PRO_0000118052"},{"type":"Transmembrane","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":496,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":512,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":564,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":621,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"geneLocations":[{"geneEncodingType":"Mitochondrion"}],"keywords":[{"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"id":"KW-0520","category":"Ligand","name":"NAD"},{"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-4UH8N3UAV6NIE","citationType":"journal article","authors":["Paquin B.","Roewer I.","Wang Z.","Lang B.F."],"title":"A robust fungal phylogeny using the mitochondrially encoded nad5 protein sequence.","publicationDate":"1995","journal":"Can. J. Bot.","firstPage":"S180","lastPage":"S185","volume":"73"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 46923 / Burma 3-35 (35OC)","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 46923 / Burma 3-35 (35OC)","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U17010","properties":[{"key":"ProteinId","value":"AAB05846.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49228.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63645","properties":[{"key":"EntryName","value":"S63645"}]},{"database":"RefSeq","id":"NP_043727.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"P50365","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P50365","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801885","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp08","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR010934","properties":[{"key":"EntryName","value":"NADH_DH_su5_C"}]},{"database":"InterPro","id":"IPR018393","properties":[{"key":"EntryName","value":"NADHpl_OxRdtase_5_subgr"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"InterPro","id":"IPR003945","properties":[{"key":"EntryName","value":"NU5C-like"}]},{"database":"InterPro","id":"IPR001516","properties":[{"key":"EntryName","value":"Proton_antipo_N"}]},{"database":"NCBIfam","id":"TIGR01974","properties":[{"key":"EntryName","value":"NDH_I_L"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF005141","properties":[{"key":"EntryName","value":"nuoL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42829","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42829:SF2","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06455","properties":[{"key":"EntryName","value":"NADH5_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00662","properties":[{"key":"EntryName","value":"Proton_antipo_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01434","properties":[{"key":"EntryName","value":"NADHDHGNASE5"}]},{"database":"PRINTS","id":"PR01435","properties":[{"key":"EntryName","value":"NPOXDRDTASE5"}]}],"sequence":{"value":"MYLTIITLPLFAFLTVGVIGRKLGVRGSQIITSLSIIISAILSLYGFYEIVLLNNLGPITIYLSPWMNVIGAHADWAFYFDSISITMCVVVSSISSLVHLYSIGYMQGDPHIQRFFSYLSLFTFFMLLLVTGNNYLLMFVGWEGIGVSSYLLINFWFTRIQANKASMQAMLVNRVGDLGFVLGLFGIFWLFGSSDYDTVGIIAYKLDEQYITIVTLFLLIAAIGKSAQLGLHTWLPSAMEGPTPVSALIHAATLVTAGVYLILRSSPLFELAPTSLICVCVIGSLTAIFAATTGLFQNDLKRVIAYSTCSQLGYMVFALGLSQYEVAFFHLFNHAYFKALLFLSAGSIIHALHDEQDMRKMGGLVNILPFTYTMILIGSLSLMALPFLTGYYSKDAILEVAYGQFLVTGTFTYWLGTITATITAFYSSKALILGFFGTPNGSKKIYNTIHEAPLIMSIPLFLLSICSIFIGYITNKHLSVIGIGSSGIISGGVGTLRDHYLGFDIEFISTSFGVQFYPLFASLLGISLALIVLKDPKKMHSIEKPEGLLNTVNITRWLSSKSYWFDNVYNTVLISGSLHFGGIFARDIDKGFLSLLGPQGLQQLLITISRFFAIKIDTGFIPHYASIIIIIPIFIILSIFI","length":641,"molWeight":70675,"crc64":"9C64C376B72E7E61","md5":"A904837A9069041EB08D7E8EEAE7318A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":17},"uniParcId":"UPI00001307C9"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q37399","uniProtkbId":"NU3M_ALLMA","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":75,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"NADH-ubiquinone oxidoreductase chain 3"},"ecNumbers":[{"value":"7.1.1.2"}]},"alternativeNames":[{"fullName":{"value":"NADH dehydrogenase subunit 3"}}]},"genes":[{"geneName":{"value":"ND3"},"synonyms":[{"value":"NAD3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2"}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the complex I subunit 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"NADH-ubiquinone oxidoreductase chain 3","featureId":"PRO_0000117702"},{"type":"Transmembrane","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"geneLocations":[{"geneEncodingType":"Mitochondrion"}],"keywords":[{"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0520","category":"Ligand","name":"NAD"},{"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 46923 / Burma 3-35 (35OC)","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49240.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63657","properties":[{"key":"EntryName","value":"S63657"}]},{"database":"RefSeq","id":"NP_043739.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q37399","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q37399","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801838","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp20","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030964","properties":[{"key":"GoTerm","value":"C:NADH dehydrogenase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"FunFam","id":"1.20.58.1610:FF:000004","properties":[{"key":"EntryName","value":"NADH-quinone oxidoreductase subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1610","properties":[{"key":"EntryName","value":"NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000440","properties":[{"key":"EntryName","value":"NADH_UbQ/plastoQ_OxRdtase_su3"}]},{"database":"InterPro","id":"IPR038430","properties":[{"key":"EntryName","value":"NDAH_ubi_oxred_su3_sf"}]},{"database":"PANTHER","id":"PTHR11058","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11058:SF9","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00507","properties":[{"key":"EntryName","value":"Oxidored_q4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTYLVYIVFTIVLTVGLILVSYLLSQAQPDSEKVSAYECGFSPLGDARQKFDVSFYLIAILFIIFDLEVVFILPFASVIHNVSLLGGWITIIFLVILTIGFIYEFVSGAITDSF","length":114,"molWeight":12715,"crc64":"7CF6092F508D3A53","md5":"7656D3CE0BE82EDA2A5F3FE976DBE205"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":3},"uniParcId":"UPI00001306C2"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q37403","uniProtkbId":"NU4LM_ALLMA","entryAudit":{"firstPublicDate":"2005-03-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":84,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"NADH-ubiquinone oxidoreductase chain 4L"},"ecNumbers":[{"value":"7.1.1.2"}]},"alternativeNames":[{"fullName":{"value":"NADH dehydrogenase subunit 4L"}}]},"genes":[{"geneName":{"value":"ND4L"},"synonyms":[{"value":"NAD4L"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2"}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the complex I subunit 4L family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"NADH-ubiquinone oxidoreductase chain 4L","featureId":"PRO_0000118382"},{"type":"Transmembrane","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"geneLocations":[{"geneEncodingType":"Mitochondrion"}],"keywords":[{"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0520","category":"Ligand","name":"NAD"},{"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49245.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63662","properties":[{"key":"EntryName","value":"S63662"}]},{"database":"RefSeq","id":"NP_043744.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q37403","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q37403","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801851","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp25","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030964","properties":[{"key":"GoTerm","value":"C:NADH dehydrogenase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.287.3510","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001133","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_chain4L/K"}]},{"database":"InterPro","id":"IPR039428","properties":[{"key":"EntryName","value":"NUOK/Mnh_C1-like"}]},{"database":"PANTHER","id":"PTHR11434:SF16","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11434","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00420","properties":[{"key":"EntryName","value":"Oxidored_q2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLLEIITAYKIGTILFLIGILGFIINRQNILLLIISIEMTLLAISFIIICSALFLDDSAAACFSLYILALAGSEAAIGLSLLVLFHRFRGSVLISASRQ","length":99,"molWeight":10745,"crc64":"750D5FF1F44E02B3","md5":"4DDA056825950E604E3AA26DC258CF23"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":3},"uniParcId":"UPI0000098DB8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2D0WD11","uniProtkbId":"A0A2D0WD11_ALLMA","entryAudit":{"firstPublicDate":"2018-01-31","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-01-31","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29921.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29921.1"}],"value":"Putative ethylene receptor 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29921.1"}],"value":"ETR1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":1015,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5053809434"},{"type":"Transmembrane","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":633,"modifier":"EXACT"}},"description":"Histidine kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50109"}]},{"type":"Domain","location":{"start":{"value":957,"modifier":"EXACT"},"end":{"value":1015,"modifier":"EXACT"}},"description":"Response regulatory","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50110"}]},{"type":"Region","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":548,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":918,"modifier":"EXACT"},"end":{"value":948,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":918,"modifier":"EXACT"},"end":{"value":934,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":935,"modifier":"EXACT"},"end":{"value":947,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1007,"modifier":"EXACT"},"end":{"value":1007,"modifier":"EXACT"}},"description":"4-aspartylphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29921.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023012"}],"id":"KW-0902","category":"Biological process","name":"Two-component regulatory system"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2FQL44AL3JJJO","citationType":"submission","authors":["Shamseldin A.","Moawad H.","Abd El-Rahim W.M.","Sadowsky M.J."],"publicationDate":"DEC-2015","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29921.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU297226","properties":[{"key":"ProteinId","value":"APW29921.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A2D0WD11","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AMAG_09825","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0016301","properties":[{"key":"GoTerm","value":"F:kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000160","properties":[{"key":"GoTerm","value":"P:phosphorelay signal transduction system"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd17546","properties":[{"key":"EntryName","value":"REC_hyHK_CKI1_RcsC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011006","properties":[{"key":"EntryName","value":"CheY-like_sf"}]},{"database":"InterPro","id":"IPR058544","properties":[{"key":"EntryName","value":"ETR1_N"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR003594","properties":[{"key":"EntryName","value":"HATPase_dom"}]},{"database":"InterPro","id":"IPR005467","properties":[{"key":"EntryName","value":"His_kinase_dom"}]},{"database":"InterPro","id":"IPR004358","properties":[{"key":"EntryName","value":"Sig_transdc_His_kin-like_C"}]},{"database":"InterPro","id":"IPR001789","properties":[{"key":"EntryName","value":"Sig_transdc_resp-reg_receiver"}]},{"database":"PANTHER","id":"PTHR45339","properties":[{"key":"EntryName","value":"HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45339:SF1","properties":[{"key":"EntryName","value":"HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25487","properties":[{"key":"EntryName","value":"ETR1_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02518","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00072","properties":[{"key":"EntryName","value":"Response_reg"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00344","properties":[{"key":"EntryName","value":"BCTRLSENSOR"}]},{"database":"SMART","id":"SM00387","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF52172","properties":[{"key":"EntryName","value":"CheY-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50109","properties":[{"key":"EntryName","value":"HIS_KIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50110","properties":[{"key":"EntryName","value":"RESPONSE_REGULATORY"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRALAAAFTAVALVATIGAFGAAAAAATANANANPTVLHLGGQGEWHFARSSQAGPNAPPPPPSPPSPPSPPPSSAPVSSSSPPSRDGTASNGGISSISSGMSTLMTVEMVADLLIGLAYVAIPCMIAFFQRQLVGATSPTYRGLLVLFQAFILCCGATHILHALRFSSDSILLVVTKVITAAVSCLTSAMLFWVVPVAFSMPARLHRLESELGEMIREANRRQYGVHDGARRPLRELTARLRHEQLAESPGVDGAGGGANSAAAGGSSSNIATTTPNAEDHHVDSEDEYKALPLERVCHLAVRAIAQSVPGFASVLMFMEPARDSVAPVAAPAELTTSGAGAGDDAVQPDWMGPGLRCIAEYHPAAPSSSARAAGERLVLAHAPFRLRTCIEACLDLVAPRLEHVDVALNYILDADVPEVVAGDRTRVTQILANLLGNAAKFTEQGEILVIVSTRPRRVVDPAVFTSVRKLDFRNPAQGVTPATLVAVSPESIDRAGRPVESATPAEGDRKSSLSPGSRHREATSASSASAPDPLSPRLATQSRTRTNSLGGHTGYLYFYVVDTGCGIHQHDMGRLFERFQQGQQGAARRQHGTGLGLAVSARLVELHGGQMAVQSAPGAGTVFSFSLRMQYAGAAHAGDHDDVVHAAAVAWEPLWQAPAAPLGSPWTGLELVVVPDPRLASSARSLGSLLDAIGCAYTCVPTVAQAQRVARRLHAAHVEPIHVAFLVVERALLAPATAPGSATDGGRGRRQELRAELLALQAIGPIALLTRRGRGDELTVDVTWFDYVLRKPVKRLSLERVLHKIADKHAQSSDAPPVVTDDVAAPLPTVVPTQVSVAVPVAVRVPDANSPAIAAAAAGAAAGGFPAAGAAAAFPGIQRHDSVMLHSVLDRPFVADFPTHRSPAAAGTPPAVAPFPLPPLIEPMATPSPAPSTPTSITTSRTTATPEREDWMRQAVLVLDDNVINLKVAQKLLKSIGVTAITTANHGGEAVDMVERGAFDIVFMDVSMPVMLG","length":1015,"molWeight":105920,"crc64":"2090F64879195BDE","md5":"0EC88B29ED223FCB6667B5CE4BBC2C95"},"extraAttributes":{"countByCommentType":{"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":3,"Domain":2,"Region":4,"Compositional bias":5,"Modified residue":1},"uniParcId":"UPI0006771B61"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A1YIB9","uniProtkbId":"A1YIB9_ALLMA","entryAudit":{"firstPublicDate":"2007-02-06","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-02-06","entryVersion":59,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM26998.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004279"}],"value":"DNA-directed RNA polymerase subunit"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004279"}],"value":"2.7.7.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM26998.1"}],"value":"RPB1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004279"}],"value":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21248"},{"database":"Rhea","id":"RHEA-COMP:14527"},{"database":"Rhea","id":"RHEA-COMP:17342"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61557"},{"database":"ChEBI","id":"CHEBI:140395"}],"ecNumber":"2.7.7.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048552"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004279"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006460"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004279"}],"value":"Belongs to the RNA polymerase beta' chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"RNA polymerase N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00663"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM26998.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":1008,"modifier":"EXACT"},"end":{"value":1008,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM26998.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022478"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004279"}],"id":"KW-0240","category":"Cellular component","name":"DNA-directed RNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004279"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004279"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004279"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"17010206","citationType":"journal article","authors":["Liu Y.J.","Hodson M.C.","Hall B.D."],"citationCrossReferences":[{"database":"PubMed","id":"17010206"},{"database":"DOI","id":"10.1186/1471-2148-6-74"}],"title":"Loss of the flagellum happened only once in the fungal lineage: phylogenetic structure of kingdom Fungi inferred from RNA polymerase II subunit genes.","publicationDate":"2006","journal":"BMC Evol. Biol.","firstPage":"74","lastPage":"74","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM26998.1"}],"value":"Burma 3-35","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM26998.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF014385","properties":[{"key":"ProteinId","value":"ABM26998.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A1YIB9","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AMAG_09650","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005665","properties":[{"key":"GoTerm","value":"C:RNA polymerase II, core complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003899","properties":[{"key":"GoTerm","value":"F:DNA-directed RNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd02733","properties":[{"key":"EntryName","value":"RNAP_II_RPB1_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.132.30:FF:000001","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.274.100:FF:000001","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.40.20:FF:000018","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1490.180:FF:000001","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.132.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.40.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.250.2940","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.20.50.80","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1490.180","properties":[{"key":"EntryName","value":"RNA polymerase ii"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.274.100","properties":[{"key":"EntryName","value":"RNA polymerase Rpb1, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045867","properties":[{"key":"EntryName","value":"DNA-dir_RpoC_beta_prime"}]},{"database":"InterPro","id":"IPR000722","properties":[{"key":"EntryName","value":"RNA_pol_asu"}]},{"database":"InterPro","id":"IPR006592","properties":[{"key":"EntryName","value":"RNA_pol_N"}]},{"database":"InterPro","id":"IPR007080","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_1"}]},{"database":"InterPro","id":"IPR007066","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_3"}]},{"database":"InterPro","id":"IPR042102","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_3_sf"}]},{"database":"InterPro","id":"IPR007083","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_4"}]},{"database":"InterPro","id":"IPR007081","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_5"}]},{"database":"InterPro","id":"IPR007075","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_6"}]},{"database":"InterPro","id":"IPR038120","properties":[{"key":"EntryName","value":"Rpb1_funnel_sf"}]},{"database":"NCBIfam","id":"NF006336","properties":[{"key":"EntryName","value":"PRK08566.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19376","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19376:SF37","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04997","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00623","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04983","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05000","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04998","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04992","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_6"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00663","properties":[{"key":"EntryName","value":"RPOLA_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64484","properties":[{"key":"EntryName","value":"beta and beta-prime subunits of DNA dependent RNA-polymerase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"HIELARPVYHVSFLPRVKKVLECVCFHCSKLLVDPNNPLFQKARRIKDRNRRFKEVHKLCKTRTECKAADEPKEGEDPDLPAGYIQASGCGEKQPAIRKKNLTLYVQFKQANHNGEDGKQEGKQELSPSQVLQILKKISDEDCEAMGLDPVFARPEWMILTVFPVPPPPVRPSILVDGTSRGEDDLTFKLCDIIKANAFLQKAEADGVPGHRIKDHEDLLQFHVATFVDNEISGMPRAMQRSGRPIKAIRSRLKGKEGRLRGNLMGKRVDFSARTVITGDPNLSIDQVGVPRSIARNLTYPEIVTPYNINKLQELVHNGPTQHPGAKYVIRDNGDRVDLRFIGAKGNLGLQYGWIVERHLDDGDVIIFNRQPSLHKMSMMGHKVKVMPYSTFRLNLSVTSPYNADFDGDEMNMHVPQSLEAKAEIQQLCMVPLQIISPQSNKPVMGIVQDTLCGITKFTRRDTFMDKNMVMNLLMWVPNWDGNVPPPAIMKPKPLWTGKQILSLVIPKVNCITHHSTHPDDESTDISPGDTRVIVEDGELLAGIVCKKTVGAAAGGLVHVSWMEHGPEAAKALLNGCQTIVNYWLLHNGFSIGIGDTIADDATMAQINKIIASARDTVKQTIHTAQRGQLKAMTGMTLRETFEAQVNRALNEAVNKAGSAAAKSFKVSNNVKQMVVSGSKGSNINISQMSACVGQQNVEGKRIPFGFQYRSLPHFVKDDYSPESRGFVENSYLRGLSPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKALEDIMVKYDGTVRNAQGHIIQFAYGEDGMDGTRVEAQILEPLRMNNHRFERRYRIDLTDPEGKKGLKPGSVEFGIQQEMQSIEVQQLLDQEYRQLEEDRERLRHIFPRGDARWPLPGNIQRIIWNAQNLFKIDKTKPSNLHPEYVVNEVRKLCDKLMVIPGTDKISVEAQRNATLLSQILVRSTLATKRVIEEFRLDKRAFDYVLGEIATRFAQSLVHAGEMVGIIAAQSIGEPAT","length":1008,"molWeight":112976,"crc64":"728630BEE7331171","md5":"4ACED53D83F7F46BEC0616863FA79549"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0000ECFD4C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A1YID5","uniProtkbId":"A1YID5_ALLMA","entryAudit":{"firstPublicDate":"2007-02-06","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-02-06","entryVersion":74,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27014.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"value":"DNA-directed RNA polymerase subunit beta"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"value":"2.7.7.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27014.1"}],"value":"RPB2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"value":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21248"},{"database":"Rhea","id":"RHEA-COMP:14527"},{"database":"Rhea","id":"RHEA-COMP:17342"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61557"},{"database":"ChEBI","id":"CHEBI:140395"}],"ecNumber":"2.7.7.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048552"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011730"}],"value":"Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006835"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000434"}],"value":"Belongs to the RNA polymerase beta chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"RNA polymerase beta subunit protrusion","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04563"}]},{"type":"Domain","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04561"}]},{"type":"Domain","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04565"}]},{"type":"Domain","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04566"}]},{"type":"Domain","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04567"}]},{"type":"Domain","location":{"start":{"value":526,"modifier":"EXACT"},"end":{"value":867,"modifier":"EXACT"}},"description":"DNA-directed RNA polymerase subunit 2 hybrid-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00562"}]},{"type":"Region","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":707,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27014.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":867,"modifier":"EXACT"},"end":{"value":867,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27014.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022478"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0240","category":"Cellular component","name":"DNA-directed RNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"17010206","citationType":"journal article","authors":["Liu Y.J.","Hodson M.C.","Hall B.D."],"citationCrossReferences":[{"database":"PubMed","id":"17010206"},{"database":"DOI","id":"10.1186/1471-2148-6-74"}],"title":"Loss of the flagellum happened only once in the fungal lineage: phylogenetic structure of kingdom Fungi inferred from RNA polymerase II subunit genes.","publicationDate":"2006","journal":"BMC Evol. Biol.","firstPage":"74","lastPage":"74","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27014.1"}],"value":"Burma 3-35","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27014.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF014403","properties":[{"key":"ProteinId","value":"ABM27014.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A1YID5","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AMAG_10446","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005665","properties":[{"key":"GoTerm","value":"C:RNA polymerase II, core complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003899","properties":[{"key":"GoTerm","value":"F:DNA-directed RNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0032549","properties":[{"key":"GoTerm","value":"F:ribonucleoside binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006367","properties":[{"key":"GoTerm","value":"P:transcription initiation at RNA polymerase II promoter"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00653","properties":[{"key":"EntryName","value":"RNA_pol_B_RPB2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.150:FF:000002","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1070.20:FF:000001","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.150","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1070.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.270.10","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase, subunit 2, domain 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1110.10","properties":[{"key":"EntryName","value":"RNA polymerase Rpb2, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR015712","properties":[{"key":"EntryName","value":"DNA-dir_RNA_pol_su2"}]},{"database":"InterPro","id":"IPR007120","properties":[{"key":"EntryName","value":"DNA-dir_RNAP_su2_dom"}]},{"database":"InterPro","id":"IPR037033","properties":[{"key":"EntryName","value":"DNA-dir_RNAP_su2_hyb_sf"}]},{"database":"InterPro","id":"IPR007121","properties":[{"key":"EntryName","value":"RNA_pol_bsu_CS"}]},{"database":"InterPro","id":"IPR007644","properties":[{"key":"EntryName","value":"RNA_pol_bsu_protrusion"}]},{"database":"InterPro","id":"IPR007642","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"}]},{"database":"InterPro","id":"IPR037034","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2_sf"}]},{"database":"InterPro","id":"IPR007645","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"}]},{"database":"InterPro","id":"IPR007646","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_4"}]},{"database":"InterPro","id":"IPR007647","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_5"}]},{"database":"InterPro","id":"IPR014724","properties":[{"key":"EntryName","value":"RNA_pol_RPB2_OB-fold"}]},{"database":"PANTHER","id":"PTHR20856","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04563","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04561","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04565","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04566","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04567","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00562","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_6"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64484","properties":[{"key":"EntryName","value":"beta and beta-prime subunits of DNA dependent RNA-polymerase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01166","properties":[{"key":"EntryName","value":"RNA_POL_BETA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SEKVIIAQERTATNTVFVFSKPPPSAVLFQAEIRSQAEDGPKTLSSFIVKMSRDQNITASLPYIQQDIPIMVLFRALGLVADRDILERICYDFSDDQMLEMLKPSIDNAFTIQEREIALDFIGKRGRNIGLTRDKRIRYAHDLLERELLPHIGITPGCQTRKSYFIGYMVHRLLLAALGRRQVDDRDHFGKKRLDLAGPLLASLFRTFFQKLTKDVSRYFTVCIERGREFNLNMAINSNTITNGLRYALATGNWGDQKKFMETRAGVSQVLNRYTFASTLSHLRRLNTPIGREGKLAKPRQLHNTHWGMVCPAETPEGQACGLVKNLALMAYISVGSASGPILEFLEEWTTENLEEITASAIGSNTKVFVNGSWVGIHRQPDSLVQTLISLRRSGDIMPEVSVVRDVRDNELRIYTDAGRICRPLFIVNEQQQLVLRRDHVARLEVGEWGWEDLLANGIVEYLDTEEEETTMICMTPDDLAESRGDPIPDKSKLDKTARLKSRKAGDVCKQWSHCEIHPSMILGICASIIPFPDHNQSPRNTYQSAMGKQAMGLYLTNFQLRMDTLANILYYPQKPLVATRSMKYLRFRELPAGQNAVVAIAVYSGYNQEDSIIMNQSSIDRGLFRSIYYRAYMDQEKKSGFSDVETFEKPTRETTLKLRHGSYDKIEEDGLVAPGTRVTGDDIIIGKTAPLPPDTSEMGARTTQTKKDVSTSLKSTEQGIVDHVMLTTNNDGYKFVKVRVRSTRVPQMGDKFASRHGQKGTVGMTYRQEDMPFSADGVTPDLIVNPHAIPSRMTIGHLVECLLSKVGSLTGTEGDATPFTDITVQEIADRLRSCGYQQRGFEIMYNGHTGKKLAAQVFFGPTYYQR","length":867,"molWeight":97654,"crc64":"D3D4EF81F2F0FDCF","md5":"F6FFB4C85C63E6F34EBBC6F749D89C3D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Domain":6,"Region":1,"Non-terminal residue":2},"uniParcId":"UPI0000ECFD5D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A1YID6","uniProtkbId":"A1YID6_ALLMA","entryAudit":{"firstPublicDate":"2007-02-06","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-02-06","entryVersion":74,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27015.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"value":"DNA-directed RNA polymerase subunit beta"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"value":"2.7.7.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27015.1"}],"value":"RPB2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"value":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21248"},{"database":"Rhea","id":"RHEA-COMP:14527"},{"database":"Rhea","id":"RHEA-COMP:17342"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61557"},{"database":"ChEBI","id":"CHEBI:140395"}],"ecNumber":"2.7.7.6","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048552"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011730"}],"value":"Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006835"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000434"}],"value":"Belongs to the RNA polymerase beta chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"RNA polymerase beta subunit protrusion","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04563"}]},{"type":"Domain","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04561"}]},{"type":"Domain","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":333,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04565"}]},{"type":"Domain","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04566"}]},{"type":"Domain","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"RNA polymerase Rpb2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04567"}]},{"type":"Domain","location":{"start":{"value":526,"modifier":"EXACT"},"end":{"value":896,"modifier":"EXACT"}},"description":"DNA-directed RNA polymerase subunit 2 hybrid-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00562"}]},{"type":"Region","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":708,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27015.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":896,"modifier":"EXACT"},"end":{"value":896,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27015.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022478"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0240","category":"Cellular component","name":"DNA-directed RNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363031"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"17010206","citationType":"journal article","authors":["Liu Y.J.","Hodson M.C.","Hall B.D."],"citationCrossReferences":[{"database":"PubMed","id":"17010206"},{"database":"DOI","id":"10.1186/1471-2148-6-74"}],"title":"Loss of the flagellum happened only once in the fungal lineage: phylogenetic structure of kingdom Fungi inferred from RNA polymerase II subunit genes.","publicationDate":"2006","journal":"BMC Evol. Biol.","firstPage":"74","lastPage":"74","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27015.1"}],"value":"Burma 3-35","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABM27015.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF014404","properties":[{"key":"ProteinId","value":"ABM27015.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A1YID6","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AMAG_10446","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005665","properties":[{"key":"GoTerm","value":"C:RNA polymerase II, core complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003899","properties":[{"key":"GoTerm","value":"F:DNA-directed RNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0032549","properties":[{"key":"GoTerm","value":"F:ribonucleoside binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006367","properties":[{"key":"GoTerm","value":"P:transcription initiation at RNA polymerase II promoter"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00653","properties":[{"key":"EntryName","value":"RNA_pol_B_RPB2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.50.150:FF:000002","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.1070.20:FF:000001","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.150","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1070.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.270.10","properties":[{"key":"EntryName","value":"DNA-directed RNA polymerase, subunit 2, domain 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.1110.10","properties":[{"key":"EntryName","value":"RNA polymerase Rpb2, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR015712","properties":[{"key":"EntryName","value":"DNA-dir_RNA_pol_su2"}]},{"database":"InterPro","id":"IPR007120","properties":[{"key":"EntryName","value":"DNA-dir_RNAP_su2_dom"}]},{"database":"InterPro","id":"IPR037033","properties":[{"key":"EntryName","value":"DNA-dir_RNAP_su2_hyb_sf"}]},{"database":"InterPro","id":"IPR007121","properties":[{"key":"EntryName","value":"RNA_pol_bsu_CS"}]},{"database":"InterPro","id":"IPR007644","properties":[{"key":"EntryName","value":"RNA_pol_bsu_protrusion"}]},{"database":"InterPro","id":"IPR007642","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"}]},{"database":"InterPro","id":"IPR037034","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2_sf"}]},{"database":"InterPro","id":"IPR007645","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"}]},{"database":"InterPro","id":"IPR007646","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_4"}]},{"database":"InterPro","id":"IPR007647","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_5"}]},{"database":"InterPro","id":"IPR014724","properties":[{"key":"EntryName","value":"RNA_pol_RPB2_OB-fold"}]},{"database":"PANTHER","id":"PTHR20856","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04563","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04561","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04565","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04566","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04567","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00562","properties":[{"key":"EntryName","value":"RNA_pol_Rpb2_6"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64484","properties":[{"key":"EntryName","value":"beta and beta-prime subunits of DNA dependent RNA-polymerase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01166","properties":[{"key":"EntryName","value":"RNA_POL_BETA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SEKVIIAQERTATNTVFVFSKPPPSAVLFQAEIRSQAEDGPKTLSSFIVKMSRDQNITASLPYIQQDIPIMVLFRALGLVADRDILERICYDFSDDQMLEMLKPSIDNAFTIQEREVALDFIGKRGRNIGLTRDKRIRYAHDLLERELLPHIGITPGCQTRKSYFIGYMVHRLLLAALGRRQVDDRDHFGKKRLDLAGPLLASLFRTFFQKLTKDVSRYFTVCIERGREFNLNMAINSNTITNGLRYALATGNWGDQKKFMETRAGVSQVLNRYTFASTLSHLRRLNTPIGREGKLAKPRQLHNTHWGMVCPAETPEGQACGLVKNLALMAYISVGSASGPILEFLEEWTTENLEEITASAIGSNTKVFVNGSWVGIHRQPDSLVQTLISLRRSGDIMPEVSVVRDVRDNELRIYTDAGRICRPLFIVNEQQQLVLRRDHVARLEVGEWGWEELLANGIVEYLDTEEEETTMICMTPDDLAESRGDPIPDKSKLDKTARLKSRKAGDVCKQWSHCEIHPSMILGICASIIPFPDHNQSPRNTYQSAMGKQAMGLYLTNFQLRMDTLANILYYPQKPLVATRSMKYLRFRELPAGQNAVVAIAVYSGYNQEDSIIMNQSSIDRGLFRSIYYRAYMDQEKKSGFSDVETFEKPARETTLKLRHGSYDKIEEDGLVAPGTRVTGDDIIIGKTAPLPPDTSEMGARTTQTKKDVSTSLKSTEQGIVDHVMLTTNNDGYKFVKVRVRSTRVPQMGDKFASRHGQKGTVGMTYRQEDMPFSADGVTPDLIVNPHAIPSRMTIGHLVECLLSKVGSLTGTEGDATPFTDITVQEIADRLRSCGYQQRGFEIMYNGHTGKKLAAQVFFGPTYYQRLKHMVDDKIHSRARGPLQILTRQPVEGRS","length":896,"molWeight":100944,"crc64":"2B15026E7E38FFC4","md5":"C827194DCBFBA49AF966AC06E7F48EEB"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Domain":6,"Region":1,"Non-terminal residue":2},"uniParcId":"UPI0000ECFD5E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q27SS1","uniProtkbId":"Q27SS1_ALLMA","entryAudit":{"firstPublicDate":"2006-04-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-04-04","entryVersion":63,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABD46617.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00095026"}],"value":"Zeta-crystallin"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038919"}],"value":"1.6.5.5"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043088"}],"value":"NADPH:quinone reductase"}}],"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094201"}],"value":"Multifunctional crystallin endowed with unrelated mRNA stabilization and enzymatic oxidoreductase activities. Binds (AU)-rich elements (ARE) in the 3'-UTR of target mRNA to enhance their stability. Upon metabolic acidosis, stabilizes the mRNA encoding SLC12A1 a cotransporter involved in transepithelial NH4(+) reabsorption in the medullary thick ascending limb in kidney. In response to acidosis, also participates to the adaptive increase in renal ammoniagenesis by stabilizing the mRNAs of enzymes involved in glutamine catabolism. By the same mechanism, it also regulates the expression of the antiapoptotic protein BCL2. Beside its mRNA stabilization activity, also catalyzes the reduction of orthoquinones such as 1,2-naphthoquinone or 9,10-phenanthrenequinone in the presence of NADPH in vitro and could be involved in the detoxification of xenobiotics and protection against oxidative stress"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85243"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:34055"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:234268"}],"ecNumber":"1.6.5.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00093827"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 9,10-phenanthroquinone + NADPH + H(+) = 2 9,10-phenanthrosemiquinone + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85247"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:37454"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:234267"}],"ecNumber":"1.6.5.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00093896"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 a quinone + NADPH + H(+) = 2 a 1,4-benzosemiquinone + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:14269"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:132124"},{"database":"ChEBI","id":"CHEBI:134225"}],"ecNumber":"1.6.5.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048980"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011881"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"Enoyl reductase (ER)","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00829"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABD46617.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABD46617.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"17086451","citationType":"journal article","authors":["Watkins R.F.","Gray M.W."],"citationCrossReferences":[{"database":"PubMed","id":"17086451"},{"database":"DOI","id":"10.1007/s00239-006-0031-0"}],"title":"The frequency of eubacterium-to-eukaryote lateral gene transfers shows significant cross-taxa variation within amoebozoa.","publicationDate":"2006","journal":"J. Mol. Evol.","firstPage":"801","lastPage":"814","volume":"63"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABD46617.1"}]},{"referenceNumber":2,"citation":{"id":"CI-AJGJU46MAKSVJ","citationType":"submission","authors":["Lang B.F.","Burger G."],"publicationDate":"JAN-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABD46617.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ384287","properties":[{"key":"ProteinId","value":"ABD46617.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q27SS1","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AMAG_19900","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003960","properties":[{"key":"GoTerm","value":"F:quinone reductase (NADPH) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.90.180.10","properties":[{"key":"EntryName","value":"Medium-chain alcohol dehydrogenases, catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013149","properties":[{"key":"EntryName","value":"ADH-like_C"}]},{"database":"InterPro","id":"IPR013154","properties":[{"key":"EntryName","value":"ADH-like_N"}]},{"database":"InterPro","id":"IPR020843","properties":[{"key":"EntryName","value":"ER"}]},{"database":"InterPro","id":"IPR011032","properties":[{"key":"EntryName","value":"GroES-like_sf"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR002364","properties":[{"key":"EntryName","value":"Quin_OxRdtase/zeta-crystal_CS"}]},{"database":"InterPro","id":"IPR051603","properties":[{"key":"EntryName","value":"Zinc-ADH_QOR/CCCR"}]},{"database":"PANTHER","id":"PTHR44154","properties":[{"key":"EntryName","value":"QUINONE OXIDOREDUCTASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR44154:SF1","properties":[{"key":"EntryName","value":"QUINONE OXIDOREDUCTASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08240","properties":[{"key":"EntryName","value":"ADH_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00107","properties":[{"key":"EntryName","value":"ADH_zinc_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00829","properties":[{"key":"EntryName","value":"PKS_ER"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50129","properties":[{"key":"EntryName","value":"GroES-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01162","properties":[{"key":"EntryName","value":"QOR_ZETA_CRYSTAL"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"PLPAPKKGQVLVEVKAVGANFFDILLVQGKYQYKPKGDFIPGTEFAGIVRQVGPGVTGFAAGDRVFGAVQVGAYATHVLADTHSLFKIPGALSFEEASGIFITYPTSYAALVLRANVQPGETVLVHAGAGGVGLAAIQIAKLLGATVIGTASSPEKLAIMRAQGADHV","length":168,"molWeight":17255,"crc64":"B85EB57B3CE5174E","md5":"4543F11779B82F3FC0A31FFF3BAB629A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":3,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00006C9C2F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q33759","uniProtkbId":"Q33759_ALLMA","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1996-11-01","entryVersion":77,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49235.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49235.1"}],"value":"Orf785 protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49235.1"}],"value":"orf785"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22508"},{"database":"Rhea","id":"RHEA-COMP:17339"},{"database":"Rhea","id":"RHEA-COMP:17340"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61560"},{"database":"ChEBI","id":"CHEBI:173112"}],"ecNumber":"2.7.7.49","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22508"},{"database":"Rhea","id":"RHEA-COMP:17339"},{"database":"Rhea","id":"RHEA-COMP:17340"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:61560"},{"database":"ChEBI","id":"CHEBI:173112"}],"ecNumber":"2.7.7.7","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}]}}],"features":[{"type":"Domain","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"Reverse transcriptase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50878"}]},{"type":"Region","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":483,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","note":"catalytic"}}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49235.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0239","category":"Molecular function","name":"DNA-directed DNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49235.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0695","category":"Molecular function","name":"RNA-directed DNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00405"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49235.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49235.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63652","properties":[{"key":"EntryName","value":"S63652"}]},{"database":"RefSeq","id":"NP_043734.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q33759","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801882","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp15","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003887","properties":[{"key":"GoTerm","value":"F:DNA-directed DNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003964","properties":[{"key":"GoTerm","value":"F:RNA-directed DNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006315","properties":[{"key":"GoTerm","value":"P:homing of group II introns"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0090615","properties":[{"key":"GoTerm","value":"P:mitochondrial mRNA processing"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00085","properties":[{"key":"EntryName","value":"HNHc"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01651","properties":[{"key":"EntryName","value":"RT_G2_intron"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR043502","properties":[{"key":"EntryName","value":"DNA/RNA_pol_sf"}]},{"database":"InterPro","id":"IPR024937","properties":[{"key":"EntryName","value":"Domain_X"}]},{"database":"InterPro","id":"IPR003615","properties":[{"key":"EntryName","value":"HNH_nuc"}]},{"database":"InterPro","id":"IPR000477","properties":[{"key":"EntryName","value":"RT_dom"}]},{"database":"PANTHER","id":"PTHR33642","properties":[{"key":"EntryName","value":"COX1/OXI3 INTRON 1 PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33642:SF4","properties":[{"key":"EntryName","value":"COX1_OXI3 INTRON 1 PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01348","properties":[{"key":"EntryName","value":"Intron_maturas2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00078","properties":[{"key":"EntryName","value":"RVT_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00507","properties":[{"key":"EntryName","value":"HNHc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56672","properties":[{"key":"EntryName","value":"DNA/RNA polymerases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50878","properties":[{"key":"EntryName","value":"RT_POL"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"ASLWILMGCLLGGFVADFGLTIVAEWCADFSHIIETEGFALLHKSYHLPDAEMARGPEHVINTIHCPCSLDLEVLLDRSIMVSPFIAGGASLNPVRCCNNTNLIESSVPDQSSDEANLITPPSTEDNSDVPKIDISHKESTARFPKGSNPYGDGVPIVGCGRAAQSVSEVGQRNYSTDTDAVKIGTGGYSKLVKLANGKFTGLYDTIMSIEFLLLAYRNIKSKAGNMTPGPDDQTLDGITPGFFEDLIKSLKNESFRFKSVKRTFKKKTNGKMRPLGIPAPRDKIVQEAMRILLEFIFEPIFSDFSHGFRPQRSCHTALKEVSKWNGMTWCIEGDIKSFFDNVDHKILENFLREKIEDQRFIDLFWKLVRAGYLEKGVSFDSPLGVPQGGIISPLLSNIYLHAFDMFMEKVMSDHSSDSKSISKVNPKMVSYSNKLSKLNKQYQDTKDPAILKEIRALRLERNKIPSRIRTGTRVRYVRYADDWLVGIIGPRELAVSLKEMIASFLAQELKITLSPEKTKISHFGKDLISFLGVNLRIPKPAESKVVLRKGAKGHTLARVNHTRVFFYIPVDKILAKLAAQGFLKDYVPGGKIVTNAITKWIFLDHRSIISKYNSIINGFLSYYSFVDNLNAFHLIINYILVHSCAKTLARKFRLGSRAGAFKKFGGDLAAPAPSPQDKPLGLNLKKSYAKTNKFNIKTSYRDPTEVLNWSLRTLTPFDPCWVCGSEKDIEMHHVRHLRKGVDPKQKRVTLLMSQLNRKQIPVCRSCHLKIHKGLYNGPSIRNLK","length":785,"molWeight":88120,"crc64":"DE501DE9561FA24F","md5":"A1EABE9444FEDF1486CFE4D6430F7045"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":1,"Binding site":3},"uniParcId":"UPI0000094A6B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q37396","uniProtkbId":"Q37396_ALLMA","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":135,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49227.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015946"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Cytochrome c oxidase subunit 2"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49227.1"}],"value":"cox2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Cu cation","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:23378"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Binds a copper A center."}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007866"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Belongs to the cytochrome c oxidase subunit 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit II transmembrane region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50999"}]},{"type":"Domain","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit II copper A binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50857"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49227.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49227.1"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49227.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49227.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63644","properties":[{"key":"EntryName","value":"S63644"}]},{"database":"RefSeq","id":"NP_043726.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q37396","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801887","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp07","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:1902494","properties":[{"key":"GoTerm","value":"C:catalytic complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0098796","properties":[{"key":"GoTerm","value":"C:membrane protein complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005507","properties":[{"key":"GoTerm","value":"F:copper ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd13912","properties":[{"key":"EntryName","value":"CcO_II_C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.90:FF:000004","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.420:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.90","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.420","properties":[{"key":"EntryName","value":"Cupredoxins - blue copper proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045187","properties":[{"key":"EntryName","value":"CcO_II"}]},{"database":"InterPro","id":"IPR002429","properties":[{"key":"EntryName","value":"CcO_II-like_C"}]},{"database":"InterPro","id":"IPR034210","properties":[{"key":"EntryName","value":"CcO_II_C"}]},{"database":"InterPro","id":"IPR001505","properties":[{"key":"EntryName","value":"Copper_CuA"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR014222","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2"}]},{"database":"InterPro","id":"IPR011759","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2_TM_dom"}]},{"database":"InterPro","id":"IPR036257","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2_TM_sf"}]},{"database":"NCBIfam","id":"TIGR02866","properties":[{"key":"EntryName","value":"CoxB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22888:SF9","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22888","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE, SUBUNIT II"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00116","properties":[{"key":"EntryName","value":"COX2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02790","properties":[{"key":"EntryName","value":"COX2_TM"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01166","properties":[{"key":"EntryName","value":"CYCOXIDASEII"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81464","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit II-like, transmembrane region"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00078","properties":[{"key":"EntryName","value":"COX2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50857","properties":[{"key":"EntryName","value":"COX2_CUA"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50999","properties":[{"key":"EntryName","value":"COX2_TM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKLLNFIYNDHPQPWQIGFQDGATTTFYGIVDLHDNIIFYLIIVIIGVTWIQTSVMLDSYGNSDKHVYKYSHHGTLVEIIWTITPALILVAIAFPSFKLLYLMDSVVDPAVTVKAIGYQWYWGYNYGDYNEDISFDSFMVPTDELEMGQFRLLEVDNRVVVPVDTRVRIVVTAADVIHSFAVPSLGIKIDAIPGRINQASFLIDREGVYYGQCSELCGANHGFMPIAIEAVSLDRYVAWVDAQLS","length":245,"molWeight":27688,"crc64":"E198ACAD66D9A3AB","md5":"9747E153F7A50D55D9EC046450CD6679"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":2,"Domain":2},"uniParcId":"UPI000008BD8A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q37397","uniProtkbId":"Q37397_ALLMA","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":74,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49238.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"NADH-ubiquinone oxidoreductase chain 6"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49238.1"}],"value":"nad6"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"value":"Belongs to the complex I subunit 6 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]},{"type":"Transmembrane","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49238.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49238.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004430"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"7490780","citationType":"journal article","authors":["Paquin B.","Forget L.","Roewer I.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"7490780"},{"database":"DOI","id":"10.1007/BF00175824"}],"title":"Molecular phylogeny of Allomyces macrogynus: congruency between nuclear ribosomal RNA- and mitochondrial protein-based trees.","publicationDate":"1995","journal":"J. Mol. Evol.","firstPage":"657","lastPage":"665","volume":"41"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49238.1"}]},{"referenceNumber":2,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49238.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49238.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63655","properties":[{"key":"EntryName","value":"S63655"}]},{"database":"RefSeq","id":"NP_043737.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q37397","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801848","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp18","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"1.20.120.1200","properties":[{"key":"EntryName","value":"NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001457","properties":[{"key":"EntryName","value":"NADH_UbQ/plastoQ_OxRdtase_su6"}]},{"database":"InterPro","id":"IPR042106","properties":[{"key":"EntryName","value":"Nuo/plastoQ_OxRdtase_6_NuoJ"}]},{"database":"PANTHER","id":"PTHR33269","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33269:SF17","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00499","properties":[{"key":"EntryName","value":"Oxidored_q3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTITWGLFYLLSGLGIISGVLTIIMGKNPINSVVYLVFCFVNCAAVFILMGISLLGFIYIIVYVGAIAILFIFVIMMMDLRNLTESNLMSGHKTFFSFYNYPLALIIAITTLLLVMKDNSHAVSVLFDTNISDMRDAHGVLVHDFTTWERIQGIHWYSSIQNSMNSVLHSVGYLLYTDFLSLLLLASLVLLMVMISVIALIKIG","length":204,"molWeight":22777,"crc64":"5857E79D0B018FFD","md5":"ECA1FE095503914938141B4F9AD4A55B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":5},"uniParcId":"UPI0000095076"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q37398","uniProtkbId":"Q37398_ALLMA","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1996-11-01","entryVersion":56,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49239.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"ATP synthase protein 8"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49239.1"}],"value":"atp8"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"value":"Belongs to the ATPase protein 8 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49239.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49239.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49239.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU368038"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49239.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49239.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63656","properties":[{"key":"EntryName","value":"S63656"}]},{"database":"RefSeq","id":"NP_043738.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q37398","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801865","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp19","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015078","properties":[{"key":"GoTerm","value":"F:proton transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0015986","properties":[{"key":"GoTerm","value":"P:proton motive force-driven ATP synthesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"InterPro","id":"IPR009230","properties":[{"key":"EntryName","value":"ATP_synth_su8_fun"}]},{"database":"Pfam","id":"PF05933","properties":[{"key":"EntryName","value":"Fun_ATP-synt_8"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPQLEPLYFINSISWTYLAFGITFVLVSKVFLPLNLKTQMIRLTLIQ","length":47,"molWeight":5503,"crc64":"59F0BDCD698E8B0F","md5":"46126FE4977E5AE9D6C6B4AA72C03D23"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":1},"uniParcId":"UPI000009668E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q37401","uniProtkbId":"Q37401_ALLMA","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1996-11-01","entryVersion":86,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49242.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"NADH-ubiquinone oxidoreductase chain 4"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49242.1"}],"value":"nad4"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003257"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009025"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Belongs to the complex I subunit 4 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":453,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Domain","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49242.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49242.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49242.1"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49242.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49242.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63659","properties":[{"key":"EntryName","value":"S63659"}]},{"database":"RefSeq","id":"NP_043741.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q37401","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801841","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp22","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0048039","properties":[{"key":"GoTerm","value":"F:ubiquinone binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR010227","properties":[{"key":"EntryName","value":"NADH_Q_OxRdtase_chainM/4"}]},{"database":"InterPro","id":"IPR003918","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"NCBIfam","id":"TIGR01972","properties":[{"key":"EntryName","value":"NDH_I_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43507","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43507:SF1","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01437","properties":[{"key":"EntryName","value":"NUOXDRDTASE4"}]}],"sequence":{"value":"MLSTLIILPLVGALIIYLGESSFTNETRLRIALIIAGINFIISIGLWIQFDENTAQFQFVEDFGSLFGQGLCHLIIGVDGISLFFVILTSFLTIPIILTPPYNGESPTAYLITLLILESMLIAVFVVLDLLLFYICFETVLIPMFLIIGIWGSKVRKIMAAYHFFLYTLLGSLFMLLGIIVIYYQTGTTDYQYLLAVLGTAESSLTRENLLWLTFFLSFAVKVPMFPVYGWLPLAHSEAPTGGSMILAGILLKLSGYGFLRYSIPLFPNASNYFTPFVLTLAVIGILYSIFACFRQTDLKSVIAYSSISHMNIVIAAIFSDNIIGIEGALFMMISHGIVSSALFFCVGALYDRTGTRILAYYRGLTMVMPLFSLCFFILILNNMAVPGGIGFIGEFLCFLGIFKTNPIICLLASLSIVLGAAYNIFLTNRLLFGSLSKYFKSYNDLTRREFMILLPFVFLSILLGLCPNIILNAIHQSCSIF","length":482,"molWeight":53575,"crc64":"41217A15F034356F","md5":"82FE788C1C9F4D187225BFBABB891B11"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":14,"Domain":1},"uniParcId":"UPI00000980A9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q37402","uniProtkbId":"Q37402_ALLMA","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":88,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49243.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"value":"NADH-ubiquinone oxidoreductase chain 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49243.1"}],"value":"nad1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010535"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Belongs to the complex I subunit 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49243.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49243.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49243.1"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49243.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49243.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63660","properties":[{"key":"EntryName","value":"S63660"}]},{"database":"RefSeq","id":"NP_043742.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q37402","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801891","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp23","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0009060","properties":[{"key":"GoTerm","value":"P:aerobic respiration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"HAMAP","id":"MF_01350","properties":[{"key":"EntryName","value":"NDH1_NuoH"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001694","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_su1/FPO"}]},{"database":"InterPro","id":"IPR018086","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_su1_CS"}]},{"database":"PANTHER","id":"PTHR11432","properties":[{"key":"EntryName","value":"NADH DEHYDROGENASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11432:SF3","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00146","properties":[{"key":"EntryName","value":"NADHdh"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00668","properties":[{"key":"EntryName","value":"COMPLEX1_ND1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLHWNLNFIISAIAPLLIVILSIVVVLLAVAYATLAERKVMGSMQRRLGPNKVGIYGLLQPLADGGKLLLKETVIPSHANLGLFLLAPILTLIFSLLGWMIIPFNNTTVIFDTPLGILFVLAISSLGIYGVIFSGWAANSKYAFLGSLRSTAQMISYEVVLGLIILTVVFCLGDAPNINQIVISQKAIWYIIPLAPLGIMFFISALAETNRPPFDLPEAESELVAGYFTEHSAMPFAYFFLGEYSSILLISTLTVILFLGGWWTPLGFLLPGSLSSFILGLKVSFIFFTFIWVRATFPRWKYTQLIVICWTSLLPLTLGFITAVPSLLLTCV","length":332,"molWeight":36516,"crc64":"39D5F74D9B0E42E2","md5":"BC472099DA6A405710742460459B7BC7"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":8},"uniParcId":"UPI000008BDB0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q37404","uniProtkbId":"Q37404_ALLMA","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":103,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49246.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019317"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"ATP synthase subunit 9, mitochondrial"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49246.1"}],"value":"atp9"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006704"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"value":"Belongs to the ATPase C chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}]},{"type":"Transmembrane","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}]},{"type":"Domain","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"V-ATPase proteolipid subunit C-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00137"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49246.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022547"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023121"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0446","category":"Ligand","name":"Lipid-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004221"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49246.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49246.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63632","properties":[{"key":"EntryName","value":"S63632"}]},{"database":"RefSeq","id":"NP_043745.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q37404","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801850","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp26","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0033177","properties":[{"key":"GoTerm","value":"C:proton-transporting two-sector ATPase complex, proton-transporting domain"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015078","properties":[{"key":"GoTerm","value":"F:proton transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015986","properties":[{"key":"GoTerm","value":"P:proton motive force-driven ATP synthesis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd18182","properties":[{"key":"EntryName","value":"ATP-synt_Fo_c_ATP5G3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.20.10:FF:000003","properties":[{"key":"EntryName","value":"Atp synthase f complex subunit mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.20.10","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit C"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01396","properties":[{"key":"EntryName","value":"ATP_synth_c_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000454","properties":[{"key":"EntryName","value":"ATP_synth_F0_csu"}]},{"database":"InterPro","id":"IPR020537","properties":[{"key":"EntryName","value":"ATP_synth_F0_csu_DDCD_BS"}]},{"database":"InterPro","id":"IPR038662","properties":[{"key":"EntryName","value":"ATP_synth_F0_csu_sf"}]},{"database":"InterPro","id":"IPR002379","properties":[{"key":"EntryName","value":"ATPase_proteolipid_c-like_dom"}]},{"database":"InterPro","id":"IPR035921","properties":[{"key":"EntryName","value":"F/V-ATP_Csub_sf"}]},{"database":"PANTHER","id":"PTHR10031","properties":[{"key":"EntryName","value":"ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10031:SF0","properties":[{"key":"EntryName","value":"ATPASE PROTEIN 9"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00137","properties":[{"key":"EntryName","value":"ATP-synt_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00124","properties":[{"key":"EntryName","value":"ATPASEC"}]},{"database":"SUPFAM","id":"SSF81333","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit C"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00605","properties":[{"key":"EntryName","value":"ATPASE_C"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIASAKIIGAGLTTMGLAGAGVGVGIVFASLIQGTSRNPAVKGDLFSYAILGFALTEALGLFSLMMAFLLLYAV","length":74,"molWeight":7454,"crc64":"9FD611C9709C0F65","md5":"43199EE8A67ECA345440F74B40A3D363"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":2,"Domain":1},"uniParcId":"UPI0000090A4F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q9P334","uniProtkbId":"Q9P334_ALLMA","entryAudit":{"firstPublicDate":"2000-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-10-01","entryVersion":98,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF31654.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF31653.1"}],"value":"Beta-tubulin 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF31654.1"}],"value":"Beta-tubulin 2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF31654.1"}],"value":"btub2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF31653.1"}],"value":"btub1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011747"}],"value":"Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009636"}],"value":"Belongs to the tubulin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Tubulin/FtsZ 2-layer sandwich","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00865"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF31654.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF31654.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"10666703","citationType":"journal article","authors":["Keeling P.J.","Luker M.A.","Palmer J.D."],"citationCrossReferences":[{"database":"PubMed","id":"10666703"}],"title":"Evidence from beta-tubulin phylogeny that microsporidia evolved from within the fungi.","publicationDate":"2000","journal":"Mol. Biol. Evol.","firstPage":"23","lastPage":"31","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF31654.1"}],"value":"ATCC 46923","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAF31654.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF162074","properties":[{"key":"ProteinId","value":"AAF31653.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF162075","properties":[{"key":"ProteinId","value":"AAF31654.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q9P334","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AMAG_07885","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005874","properties":[{"key":"GoTerm","value":"C:microtubule"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005200","properties":[{"key":"GoTerm","value":"F:structural constituent of cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000070","properties":[{"key":"GoTerm","value":"P:mitotic sister chromatid segregation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0007052","properties":[{"key":"GoTerm","value":"P:mitotic spindle organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0097435","properties":[{"key":"GoTerm","value":"P:supramolecular fiber organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd02187","properties":[{"key":"EntryName","value":"beta_tubulin"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1330.20:FF:000002","properties":[{"key":"EntryName","value":"Tubulin beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1440:FF:000056","properties":[{"key":"EntryName","value":"Tubulin beta chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.600","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1330.20","properties":[{"key":"EntryName","value":"Tubulin/FtsZ, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1440","properties":[{"key":"EntryName","value":"Tubulin/FtsZ, GTPase domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002453","properties":[{"key":"EntryName","value":"Beta_tubulin"}]},{"database":"InterPro","id":"IPR008280","properties":[{"key":"EntryName","value":"Tub_FtsZ_C"}]},{"database":"InterPro","id":"IPR000217","properties":[{"key":"EntryName","value":"Tubulin"}]},{"database":"InterPro","id":"IPR037103","properties":[{"key":"EntryName","value":"Tubulin/FtsZ-like_C"}]},{"database":"InterPro","id":"IPR018316","properties":[{"key":"EntryName","value":"Tubulin/FtsZ_2-layer-sand-dom"}]},{"database":"InterPro","id":"IPR036525","properties":[{"key":"EntryName","value":"Tubulin/FtsZ_GTPase_sf"}]},{"database":"InterPro","id":"IPR023123","properties":[{"key":"EntryName","value":"Tubulin_C"}]},{"database":"PANTHER","id":"PTHR11588","properties":[{"key":"EntryName","value":"TUBULIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03953","properties":[{"key":"EntryName","value":"Tubulin_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01163","properties":[{"key":"EntryName","value":"BETATUBULIN"}]},{"database":"PRINTS","id":"PR01161","properties":[{"key":"EntryName","value":"TUBULIN"}]},{"database":"SMART","id":"SM00865","properties":[{"key":"EntryName","value":"Tubulin_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55307","properties":[{"key":"EntryName","value":"Tubulin C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52490","properties":[{"key":"EntryName","value":"Tubulin nucleotide-binding domain-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"ATLSVHQLVENSDETFCIDNEALYDICFRTLKLTTPTYGDLNHLVSAVMSGITTCLRFPGQLNADLRKLAVNLVPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAASDPRHGRYLTVAVMFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPKGLKMSVTFIGNSTAIQELFKRISDQFTSMFRRKAFLHWYTGEG","length":218,"molWeight":24794,"crc64":"763B6B0FA07888CF","md5":"63155E461B93E503768BE92D2C79429A"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000006C445"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"V9GZV4","uniProtkbId":"V9GZV4_ALLMA","entryAudit":{"firstPublicDate":"2014-02-19","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2014-02-19","entryVersion":29,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA64934.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021312"}],"value":"ATP synthase subunit a"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032954"}],"value":"F-ATPase protein 6"}}],"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006810"}],"value":"Belongs to the ATPase A chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA64934.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA64934.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023310"}],"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022547"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA64934.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6F2KOP9QIGG1U","citationType":"submission","authors":["Lang B."],"publicationDate":"SEP-1993","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA64934.1"}],"value":"Burma 3-35","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA64934.1"}]},{"referenceNumber":2,"citation":{"id":"7991539","citationType":"journal article","authors":["Paquin B.","Laforest M.J.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"7991539"},{"database":"DOI","id":"10.1073/pnas.91.25.11807"}],"title":"Interspecific transfer of mitochondrial genes in fungi and creation of a homologous hybrid gene.","publicationDate":"1994","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"11807","lastPage":"11810","volume":"91"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA64934.1"}],"value":"Burma 3-35","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAA64934.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U02039","properties":[{"key":"ProteinId","value":"AAA64934.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"V9GZV4","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp11","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015078","properties":[{"key":"GoTerm","value":"F:proton transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015986","properties":[{"key":"GoTerm","value":"P:proton motive force-driven ATP synthesis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.20.120.220","properties":[{"key":"EntryName","value":"ATP synthase, F0 complex, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000568","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu"}]},{"database":"InterPro","id":"IPR045083","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu_bact/mt"}]},{"database":"InterPro","id":"IPR035908","properties":[{"key":"EntryName","value":"F0_ATP_A_sf"}]},{"database":"PANTHER","id":"PTHR11410","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11410:SF0","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00119","properties":[{"key":"EntryName","value":"ATP-synt_A"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81336","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit A"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VISMLSVSACMAVSSILLKGITIGLPLAVLVVLYGLELLVALLQSYVFTLLTCSYLADIVNMGDH","length":65,"molWeight":6870,"crc64":"81F9404494E7CEF4","md5":"F696403A7F1375F4EFB2C42C04D1ACCE"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":1,"Non-terminal residue":1},"uniParcId":"UPI000011DE8A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2D0WCY6","uniProtkbId":"A0A2D0WCY6_ALLMA","entryAudit":{"firstPublicDate":"2018-01-31","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-01-31","entryVersion":28,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29920.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29920.1"}],"value":"Putative ethylene receptor 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29920.1"}],"value":"ETR2"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":472,"modifier":"EXACT"},"end":{"value":734,"modifier":"EXACT"}},"description":"Histidine kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50109"}]},{"type":"Domain","location":{"start":{"value":1123,"modifier":"EXACT"},"end":{"value":1248,"modifier":"EXACT"}},"description":"Response regulatory","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50110"}]},{"type":"Region","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":993,"modifier":"EXACT"},"end":{"value":1017,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1029,"modifier":"EXACT"},"end":{"value":1054,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":475,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"Phosphohistidine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}]},{"type":"Modified residue","location":{"start":{"value":1174,"modifier":"EXACT"},"end":{"value":1174,"modifier":"EXACT"}},"description":"4-aspartylphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29920.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023012"}],"id":"KW-0902","category":"Biological process","name":"Two-component regulatory system"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2FQL44AL3JJJO","citationType":"submission","authors":["Shamseldin A.","Moawad H.","Abd El-Rahim W.M.","Sadowsky M.J."],"publicationDate":"DEC-2015","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29920.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU297225","properties":[{"key":"ProteinId","value":"APW29920.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"VEuPathDB","id":"FungiDB:AMAG_07058","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0000155","properties":[{"key":"GoTerm","value":"F:phosphorelay sensor kinase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd16922","properties":[{"key":"EntryName","value":"HATPase_EvgS-ArcB-TorS-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00082","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd17546","properties":[{"key":"EntryName","value":"REC_hyHK_CKI1_RcsC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.565.10:FF:000010","properties":[{"key":"EntryName","value":"Sensor histidine kinase RcsC"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.130","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011006","properties":[{"key":"EntryName","value":"CheY-like_sf"}]},{"database":"InterPro","id":"IPR058544","properties":[{"key":"EntryName","value":"ETR1_N"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR003594","properties":[{"key":"EntryName","value":"HATPase_dom"}]},{"database":"InterPro","id":"IPR005467","properties":[{"key":"EntryName","value":"His_kinase_dom"}]},{"database":"InterPro","id":"IPR003661","properties":[{"key":"EntryName","value":"HisK_dim/P_dom"}]},{"database":"InterPro","id":"IPR036097","properties":[{"key":"EntryName","value":"HisK_dim/P_sf"}]},{"database":"InterPro","id":"IPR004358","properties":[{"key":"EntryName","value":"Sig_transdc_His_kin-like_C"}]},{"database":"InterPro","id":"IPR001789","properties":[{"key":"EntryName","value":"Sig_transdc_resp-reg_receiver"}]},{"database":"PANTHER","id":"PTHR45339","properties":[{"key":"EntryName","value":"HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45339:SF1","properties":[{"key":"EntryName","value":"HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25487","properties":[{"key":"EntryName","value":"ETR1_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02518","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00512","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00072","properties":[{"key":"EntryName","value":"Response_reg"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00344","properties":[{"key":"EntryName","value":"BCTRLSENSOR"}]},{"database":"SMART","id":"SM00387","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00388","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00448","properties":[{"key":"EntryName","value":"REC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52172","properties":[{"key":"EntryName","value":"CheY-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47384","properties":[{"key":"EntryName","value":"Homodimeric domain of signal transducing histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50109","properties":[{"key":"EntryName","value":"HIS_KIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50110","properties":[{"key":"EntryName","value":"RESPONSE_REGULATORY"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEVAGIVSDALIAIAYFAIPCQIVYFSRFIRLEGRGVQFKSVIILFELFILLCGLSHLIKVWTADNSWLMTIVKVLTAIVSITTSALLVKLMPVVLKLPERLFVLEEELGLRIQNEQQLQAENSNLQKLRSITQSIRRTMHFQSICDIACIQLTNHFDMVGCCIFALDLPGTMTPNTAASPNSPTTPVNHATSPTSNGNNSDMALCLAEYSRLPPATSLSASSPSTGSSPPPSGTHLVVNPSGSSRQGKMTTAMSMGVLAALNAAGGGCVGVGATGVTKGMRIDLSRLVATWSKTGEWRRISATTMHGVFGISLPRSPTNKSRATLTRADSVPENPLGSGDGVALAESYKGKKDDDDEEIEIRVLATGRMDGSSPTSDRHGDANVIPEARYGTLAMMRVQGRRLIVLMMHEHEDVHASPGVVQDALGQVEIALDQSLQIEQEASRRSQMSVLETEKREAEALNGMKTVFLATISHELRTPMNAIIGFVDLLLTQYELSRDMRDILEIVSVSSSTLLNLVNDILDLSKLEFQGKQFTIEEAPLSILNVTEESVEVVYSQAERKSIKLNAILDHCVDLVLGDKLRVRQILVNLLSNAIKFTSQGSVTVTVSTKMPNTFLTLPPDHPDFARLMVPRKQRVLDYSNANVKDAPAASNGPRTQIYFQVCDTGIGVEQDKMHLLFEKFQQVDATIARRFHGTGLGLAITSRLVELHRGRVWVDSLPGVGTLFTIMLTFTPAPANVTQVPDEPAAPSLLSAASAHGSLAASADLSATSSTAPTIRIAVLDSCPIETRAIATLLKRMGCEAAAFESVAALVAAVEHDRAFESTRPLSAIVTEEDFVRALTGDDSQRLATLGLPVVTLVRIKSSSRMLIGEGLYRHTATKPLKLRTLEATLRGALEYHHNQWRRAQLGAGDSVTASQMASRDGLAKTVSAPDREAALLEVGVEPGSQAVSEAMLVPVPDAAATAEVPSGAALLAHNVTQVEAAAYEVPTSATRVAGGDSGPNSGHASPKTAAPRPLCPKQVDMLRRAEGGARPAPSTAHSSSTGLSPAARPEGKLNVAGAPVMNRSLASLAQPVLFPPARKSPIEAVRAGTAAVGSISQLIQNCGTGGAGDGGLRDTLSSLKVLVVDDNNINQMVAARTLKTLGIDKVDTANNGQEAVTYFETHPTVSIIFMDVSMPILDGLDATRAILARSSHAPPGQRRRAPFICAMTASALPEERNTCLSTGMHDFVPKPTRRQDLMQLLDRYFTWRAAQDEEEAKGSAPLGMGLLQPFLYVPPSSGKHDLQGQHP","length":1290,"molWeight":138106,"crc64":"22DC2340BAA3AF67","md5":"9FC9AA06A24D5629FF29ACC630CB74B0"},"extraAttributes":{"countByFeatureType":{"Transmembrane":3,"Domain":2,"Region":5,"Compositional bias":2,"Modified residue":2},"uniParcId":"UPI000677370D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2D0WCY9","uniProtkbId":"A0A2D0WCY9_ALLMA","entryAudit":{"firstPublicDate":"2018-01-31","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-01-31","entryVersion":27,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29919.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29919.1"}],"value":"Putative ethylene receptor 3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29919.1"}],"value":"ETR3"}}],"features":[{"type":"Transmembrane","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":953,"modifier":"EXACT"}},"description":"Histidine kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50109"}]},{"type":"Domain","location":{"start":{"value":1238,"modifier":"EXACT"},"end":{"value":1365,"modifier":"EXACT"}},"description":"Response regulatory","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50110"}]},{"type":"Region","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":756,"modifier":"EXACT"},"end":{"value":872,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":962,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1197,"modifier":"EXACT"},"end":{"value":1227,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1418,"modifier":"EXACT"},"end":{"value":1450,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":765,"modifier":"EXACT"},"end":{"value":774,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":819,"modifier":"EXACT"},"end":{"value":832,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1214,"modifier":"EXACT"},"end":{"value":1227,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1440,"modifier":"EXACT"},"end":{"value":1450,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":616,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"Phosphohistidine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}]},{"type":"Modified residue","location":{"start":{"value":1289,"modifier":"EXACT"},"end":{"value":1289,"modifier":"EXACT"}},"description":"4-aspartylphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00169"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29919.1"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00107"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2FQL44AL3JJJO","citationType":"submission","authors":["Shamseldin A.","Moawad H.","Abd El-Rahim W.M.","Sadowsky M.J."],"publicationDate":"DEC-2015","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APW29919.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU297224","properties":[{"key":"ProteinId","value":"APW29919.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"VEuPathDB","id":"FungiDB:AMAG_07095","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0000155","properties":[{"key":"GoTerm","value":"F:phosphorelay sensor kinase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00082","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd17546","properties":[{"key":"EntryName","value":"REC_hyHK_CKI1_RcsC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.130","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011006","properties":[{"key":"EntryName","value":"CheY-like_sf"}]},{"database":"InterPro","id":"IPR058544","properties":[{"key":"EntryName","value":"ETR1_N"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR003594","properties":[{"key":"EntryName","value":"HATPase_dom"}]},{"database":"InterPro","id":"IPR005467","properties":[{"key":"EntryName","value":"His_kinase_dom"}]},{"database":"InterPro","id":"IPR003661","properties":[{"key":"EntryName","value":"HisK_dim/P_dom"}]},{"database":"InterPro","id":"IPR036097","properties":[{"key":"EntryName","value":"HisK_dim/P_sf"}]},{"database":"InterPro","id":"IPR004358","properties":[{"key":"EntryName","value":"Sig_transdc_His_kin-like_C"}]},{"database":"InterPro","id":"IPR001789","properties":[{"key":"EntryName","value":"Sig_transdc_resp-reg_receiver"}]},{"database":"PANTHER","id":"PTHR45339:SF5","properties":[{"key":"EntryName","value":"HISTIDINE KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45339","properties":[{"key":"EntryName","value":"HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25487","properties":[{"key":"EntryName","value":"ETR1_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02518","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00512","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00072","properties":[{"key":"EntryName","value":"Response_reg"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00344","properties":[{"key":"EntryName","value":"BCTRLSENSOR"}]},{"database":"SMART","id":"SM00387","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00388","properties":[{"key":"EntryName","value":"HisKA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00448","properties":[{"key":"EntryName","value":"REC"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF52172","properties":[{"key":"EntryName","value":"CheY-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47384","properties":[{"key":"EntryName","value":"Homodimeric domain of signal transducing histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50109","properties":[{"key":"EntryName","value":"HIS_KIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50110","properties":[{"key":"EntryName","value":"RESPONSE_REGULATORY"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIPITRASSGSASALAMTTTSTTMALAAALVSPLLLLFVVTAGPHHATHALPVPTPDPAPGILAASPLAPNRVVSRASWHIDPPLHGPPRDPTGDPTATVWVAVSMVSDALIAFAYFAIPAQIFYFERHLQVDSLRGRLRAIVWLFEAFILACGTTHLLKVWTTSDTATLALTKAVTAIVSVVTSVALVQLMPMAMLLPGRLFLLEEELVVRAHNERVLQAENTNLTKLRAITLCVRKALEFHTICDIASVQLARHFDLVGCAVFALDAHCPVPDGPATPAAVAAALATALRSAPPSPAISHCAWRFSPVPGHVPLADMPAAAPDTHPWAQHVALGPATCVALHHTPEYADLVAAQAAAAAAASPRPSSSSNDSSSRTSTGSAPRRIRAWTRFMQRRSSTDLAATDEHTSPAPPPPTAPWSAPATPVVSAPIPGAAAATTASAPPGTLRHDDMHSPPPLPHARDMTGSTAVSGDSLATGASASTVLPPPRTPLAVGARVDFAHVAAVWSRFPQRVVLDQPAVAAILGESAVPYATLVALRAQDRVVVVALLHRDRPVGENAILHDALGQIEIALDQAVQIEYEAKRQAQMSVLEREKQEAEALNSTKTVFLATVSHELRTPMNAIIGLVDLLLTKYTLSRDMREVLEIVAVSSSTLLNLVNDLLDLSKLECQGNSFTLDHRPFSVLDVVEKSIEVVCTQAEAKGLYLCAHLDHEFNVVVGDKLRLRQVLVNLMSNAIKFTERGGVTLCVTTEEPSMLVDEGDGESPTSATSTPKTGARSERRSKRRQRILDYRQPAKATADKDRAAAAAASHVRRSSLPAPPLPPLPPPAPAAPSLSSDTLVPAQADTVPPPPPAAAAADHGRDHGEADETVLPKRSVYFQVRDTGIGIEQDNMHLLFEKFQQMDATISRRFHGTGLGLAITSRLVGLHQGRIVVDSVLGKGSVFTVELPFPVAQVAAGDAQSAPLKTPPHDSAVGAVRHAHPPPPDPVPPTELVKPSLLLSEDQRPPRTLHAPAPSIPRSPRVRHPTTGSTGIPVAVADTCAAERSAIAALLRRMGCNPVPVDSTESLCAFFESETHEPGAEAPVIADAAVRVAAAVVEDWVAWSLDEPTRRALLDHKIPVLVTAHIQLASKERATDTALAAGRTRKCKVPFRFGLSKPIKLRALHRLLRDALEECYTPAELAAAGCAMPALDPQDMFTSPDDANTDVHADSAESAAPSTAAAAAAGPDPARIPQLHVLVVDDNAINLVVAQRTLASIGVAQIGTAADGLLAVQYVDAHPDVDVILMDVSMPVMDGFEATRAILAKGARLVAGGELRAPFPYICAMTASALPEERNVCLASGMHDFVPKPARCLDLVRVLERFVEWRDAFCPGMPVVVAPQLVGAHATVAAHAALELPAPLEPIEEVASEVASVVASVKDDAGEEMPGGGGEEERVGGDRSGGTTEGQG","length":1450,"molWeight":152974,"crc64":"74CFBCAF1429CA45","md5":"C015716710E1162C4C9A76BA427800E9"},"extraAttributes":{"countByFeatureType":{"Transmembrane":3,"Domain":2,"Region":5,"Compositional bias":6,"Modified residue":2},"uniParcId":"UPI0006772CFD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q33758","uniProtkbId":"Q33758_ALLMA","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1996-11-01","entryVersion":51,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49223.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49223.1"}],"value":"OMEGA orf"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49223.1"}],"value":"orf233"}}],"features":[{"type":"Domain","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03161"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49223.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49223.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"}],"references":[{"referenceNumber":1,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49223.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49223.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63640","properties":[{"key":"EntryName","value":"S63640"}]},{"database":"RefSeq","id":"NP_043722.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q33758","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801840","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp03","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.10.28.10","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR027434","properties":[{"key":"EntryName","value":"Homing_endonucl"}]},{"database":"InterPro","id":"IPR004860","properties":[{"key":"EntryName","value":"LAGLIDADG_dom"}]},{"database":"Pfam","id":"PF03161","properties":[{"key":"EntryName","value":"LAGLIDADG_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55608","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DFSCPIWLDFSVLDSSCLPILPFNKSHTRAIKRVGPHCQDILSIIFGSLLGDAFAELRNGATRICFQQESSHREYLLWLHRKIADLGYCNPDVPEVASRPGSSGKTRFLSRFKTWSFTSFTWIHSVFYVNGVKIVPKCIELYLTPLALAIWIQDDGGAVSTTMKIATNSFTLSDIQFLCDVLDRLYNIKATPMSAGYPGQYCIYIKAESMQLIADICKPHTHPSMYYKFNGYM","length":233,"molWeight":26389,"crc64":"A94820E8EE4170AD","md5":"D09CFA0D8B2A578E987B69B4B461C457"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI000008C579"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q33760","uniProtkbId":"Q33760_ALLMA","entryAudit":{"firstPublicDate":"1996-11-01","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"1996-11-01","entryVersion":52,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Allomyces macrogynus","taxonId":28583,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49236.1"}],"lineage":["Eukaryota","Fungi","Fungi incertae sedis","Blastocladiomycota","Blastocladiomycetes","Blastocladiales","Blastocladiaceae","Allomyces"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49236.1"}],"value":"Orf176 protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49236.1"}],"value":"orf176"}}],"features":[{"type":"Domain","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"Homing endonuclease LAGLIDADG","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF03161"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49236.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49236.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"}],"references":[{"referenceNumber":1,"citation":{"id":"7490780","citationType":"journal article","authors":["Paquin B.","Forget L.","Roewer I.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"7490780"},{"database":"DOI","id":"10.1007/BF00175824"}],"title":"Molecular phylogeny of Allomyces macrogynus: congruency between nuclear ribosomal RNA- and mitochondrial protein-based trees.","publicationDate":"1995","journal":"J. Mol. Evol.","firstPage":"657","lastPage":"665","volume":"41"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49236.1"}]},{"referenceNumber":2,"citation":{"id":"8636971","citationType":"journal article","authors":["Paquin B.","Lang B.F."],"citationCrossReferences":[{"database":"PubMed","id":"8636971"},{"database":"DOI","id":"10.1006/jmbi.1996.0056"}],"title":"The mitochondrial DNA of Allomyces macrogynus: the complete genomic sequence from an ancestral fungus.","publicationDate":"1996","journal":"J. Mol. Biol.","firstPage":"688","lastPage":"701","volume":"255"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC49236.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U41288","properties":[{"key":"ProteinId","value":"AAC49236.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S63653","properties":[{"key":"EntryName","value":"S63653"}]},{"database":"RefSeq","id":"NP_043735.1","properties":[{"key":"NucleotideSequenceId","value":"NC_001715.1"}]},{"database":"AlphaFoldDB","id":"Q33760","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"801883","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:AlmafMp16","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004519","properties":[{"key":"GoTerm","value":"F:endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.10.28.10","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027434","properties":[{"key":"EntryName","value":"Homing_endonucl"}]},{"database":"InterPro","id":"IPR004860","properties":[{"key":"EntryName","value":"LAGLIDADG_dom"}]},{"database":"Pfam","id":"PF03161","properties":[{"key":"EntryName","value":"LAGLIDADG_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55608","properties":[{"key":"EntryName","value":"Homing endonucleases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRGLKRELHGLDFALSRRRYTRNSFFLFIECFVFLFKLFLSLGLDMIKELQKFTQLGISLLLTNPLFTHYHDLFYKDRKKIVPSNIYDLMTPVVLAFWIMCDGYKYNAGVALATNSFSISDNELLIDALNRKFGFSCWIINDHGQPSIFIPRVNLRKLQELVVPHIHTSLLYKIHL","length":176,"molWeight":20664,"crc64":"4FF1232680311172","md5":"16402C1B1F7630DF7F34212185706B52"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI00000973B5"}}]}