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The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile))"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007078"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_02003"}],"value":"Belongs to the class-I aminoacyl-tRNA synthetase family. 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