{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2P1L4D3","uniProtkbId":"A0A2P1L4D3_TESTE","entryAudit":{"firstPublicDate":"2018-05-23","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-05-23","entryVersion":27,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12667.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361160"}],"value":"Glyceraldehyde-3-phosphate dehydrogenase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361160"}],"value":"1.2.1.12"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10300"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57604"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"1.2.1.12","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10009"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361160"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-nitroso-L-cysteinyl-[GAPDH] + L-cysteinyl-[protein] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66684"},{"database":"Rhea","id":"RHEA-COMP:10131"},{"database":"Rhea","id":"RHEA-COMP:17089"},{"database":"Rhea","id":"RHEA-COMP:17090"},{"database":"Rhea","id":"RHEA-COMP:17091"},{"database":"ChEBI","id":"CHEBI:29950"},{"database":"ChEBI","id":"CHEBI:149494"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048005"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:66685"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048005"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004869"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361160"}],"value":"Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011881"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361160"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007406"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000397"}],"value":"Belongs to the glyceraldehyde-3-phosphate dehydrogenase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00846"}]},{"type":"Active site","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10009"}]},{"type":"Binding site","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-3"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-3"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-3"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-3"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59776"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-2"}],"ligand":{"name":"D-glyceraldehyde 3-phosphate","id":"ChEBI:CHEBI:59776"}},{"type":"Binding site","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59776"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-2"}],"ligand":{"name":"D-glyceraldehyde 3-phosphate","id":"ChEBI:CHEBI:59776"}},{"type":"Binding site","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59776"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-2"}],"ligand":{"name":"D-glyceraldehyde 3-phosphate","id":"ChEBI:CHEBI:59776"}},{"type":"Binding site","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59776"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-2"}],"ligand":{"name":"D-glyceraldehyde 3-phosphate","id":"ChEBI:CHEBI:59776"}},{"type":"Binding site","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-3"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Site","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Activates thiol group during catalysis","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-4"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023152"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361160"}],"id":"KW-0324","category":"Biological process","name":"Glycolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-3"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR000149-3"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361160"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022799"}],"id":"KW-0702","category":"PTM","name":"S-nitrosylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"29501422","citationType":"journal article","authors":["Gorbushin A.M."],"citationCrossReferences":[{"database":"PubMed","id":"29501422"}],"title":"Immune repertoire in the transcriptome of Littorina littorea reveals new trends in lophotrochozoan proto-complement evolution.","publicationDate":"2018","journal":"Dev. Comp. Immunol.","firstPage":"250","lastPage":"263","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12667.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MG596912","properties":[{"key":"ProteinId","value":"AVP12667.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A2P1L4D3","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00109","properties":[{"key":"RectionId","value":"UER00184"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004365","properties":[{"key":"GoTerm","value":"F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0051287","properties":[{"key":"GoTerm","value":"F:NAD binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0050661","properties":[{"key":"GoTerm","value":"F:NADP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0035605","properties":[{"key":"GoTerm","value":"F:peptidyl-cysteine S-nitrosylase activity"},{"key":"GoEvidenceType","value":"IEA:RHEA"}]},{"database":"GO","id":"GO:0006006","properties":[{"key":"GoTerm","value":"P:glucose metabolic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019682","properties":[{"key":"GoTerm","value":"P:glyceraldehyde-3-phosphate metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006096","properties":[{"key":"GoTerm","value":"P:glycolytic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd18126","properties":[{"key":"EntryName","value":"GAPDH_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05214","properties":[{"key":"EntryName","value":"GAPDH_I_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000266","properties":[{"key":"EntryName","value":"Glyceraldehyde-3-phosphate dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.360.10:FF:000044","properties":[{"key":"EntryName","value":"Uncharacterized protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.360.10","properties":[{"key":"EntryName","value":"Dihydrodipicolinate Reductase, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR020831","properties":[{"key":"EntryName","value":"GlycerAld/Erythrose_P_DH"}]},{"database":"InterPro","id":"IPR020830","properties":[{"key":"EntryName","value":"GlycerAld_3-P_DH_AS"}]},{"database":"InterPro","id":"IPR020829","properties":[{"key":"EntryName","value":"GlycerAld_3-P_DH_cat"}]},{"database":"InterPro","id":"IPR020828","properties":[{"key":"EntryName","value":"GlycerAld_3-P_DH_NAD(P)-bd"}]},{"database":"InterPro","id":"IPR006424","properties":[{"key":"EntryName","value":"Glyceraldehyde-3-P_DH_1"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"NCBIfam","id":"TIGR01534","properties":[{"key":"EntryName","value":"GAPDH-I"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10836","properties":[{"key":"EntryName","value":"GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10836:SF76","properties":[{"key":"EntryName","value":"GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02800","properties":[{"key":"EntryName","value":"Gp_dh_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00044","properties":[{"key":"EntryName","value":"Gp_dh_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF000149","properties":[{"key":"EntryName","value":"GAP_DH"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00078","properties":[{"key":"EntryName","value":"G3PDHDRGNASE"}]},{"database":"SMART","id":"SM00846","properties":[{"key":"EntryName","value":"Gp_dh_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55347","properties":[{"key":"EntryName","value":"Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00071","properties":[{"key":"EntryName","value":"GAPDH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALKIGINGFGRIGRLVMRAAIEKGLEIVAVNDPFIDLDYMVYMFQYDSTHGKFKGEVKAEGGKLIINGKPTIVHMLRNPEEIPWSAAGAEYVVESTGVFTTLEKAGLHFKGGAKKVVISAPSSDAPMFVMGVNENKYDKSMNVVSNASCTTNCLAPLVKVVNDSFGIVEGLMTTCHAFTATQKIVDGPSMKDWRGGRGAAQNIIPSSTGAAKAVGKVIPELNGKLTGMALRVPVADVSVVDLTVKLKNPASYDDIKAALKKASEGPMAGILGYTEDAVVSSDFISDTRSSIFDAKAGIALNDTFVKLVSWYDNEYAYSNRVIELIQHMSKQQ","length":333,"molWeight":35767,"crc64":"9ADE9C9049038898","md5":"53A3D38BF0293EE704C7C925B49F2DB0"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Active site":1,"Binding site":9,"Site":1},"uniParcId":"UPI000D213817"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A1L6KUP9","uniProtkbId":"A0A1L6KUP9_TESTE","entryAudit":{"firstPublicDate":"2017-03-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2017-03-15","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72798.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015947"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Cytochrome c oxidase subunit 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"7.1.1.9"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72798.1"}],"value":"COX1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001971"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004673"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Energy metabolism; oxidative phosphorylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009578"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Belongs to the heme-copper respiratory oxidase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit I profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50855"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72798.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72798.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72798.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72798.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"27994972","citationType":"journal article","authors":["Gusman A.","Lecomte S.","Stewart D.T.","Passamonti M.","Breton S."],"citationCrossReferences":[{"database":"PubMed","id":"27994972"}],"title":"Pursuing the quest for better understanding the taxonomic distribution of the system of doubly uniparental inheritance of mtDNA.","publicationDate":"2016","journal":"PeerJ","firstPage":"E2760","lastPage":"E2760","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72798.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KX139428","properties":[{"key":"ProteinId","value":"APR72798.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A1L6KUP9","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00705","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.210.10","properties":[{"key":"EntryName","value":"Cytochrome c oxidase-like, subunit I domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023616","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_dom"}]},{"database":"InterPro","id":"IPR036927","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_sf"}]},{"database":"InterPro","id":"IPR000883","properties":[{"key":"EntryName","value":"Cyt_C_Oxase_1"}]},{"database":"PANTHER","id":"PTHR10422","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10422:SF18","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00115","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01165","properties":[{"key":"EntryName","value":"CYCOXIDASEI"}]},{"database":"SUPFAM","id":"SSF81442","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit I-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50855","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TLSLLIRIHLMHSGSGFLVTGTLYNAVVTAHAFLMIFFMVMPVLIGGFGNWLVPMLIPAPDLGLARMNNLSFWLLPHSLVFLLVSTLTDTAVGTGWTLYPPLSSLEGHHSPCVDEAIFSLHMSGIASISASVNFITTIKHAR","length":142,"molWeight":15388,"crc64":"B6C4DBF4801EF5AD","md5":"75F135E2212F15C419273F063B837485"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":3,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00094A49CC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A1L6KUQ1","uniProtkbId":"A0A1L6KUQ1_TESTE","entryAudit":{"firstPublicDate":"2017-03-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2017-03-15","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72797.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015947"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Cytochrome c oxidase subunit 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"7.1.1.9"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72797.1"}],"value":"COX1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001971"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004673"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Energy metabolism; oxidative phosphorylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009578"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Belongs to the heme-copper respiratory oxidase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit I profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50855"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72797.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72797.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72797.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72797.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"27994972","citationType":"journal article","authors":["Gusman A.","Lecomte S.","Stewart D.T.","Passamonti M.","Breton S."],"citationCrossReferences":[{"database":"PubMed","id":"27994972"}],"title":"Pursuing the quest for better understanding the taxonomic distribution of the system of doubly uniparental inheritance of mtDNA.","publicationDate":"2016","journal":"PeerJ","firstPage":"E2760","lastPage":"E2760","volume":"4"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"APR72797.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KX139427","properties":[{"key":"ProteinId","value":"APR72797.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A1L6KUQ1","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00705","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.210.10","properties":[{"key":"EntryName","value":"Cytochrome c oxidase-like, subunit I domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023616","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_dom"}]},{"database":"InterPro","id":"IPR036927","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_sf"}]},{"database":"InterPro","id":"IPR000883","properties":[{"key":"EntryName","value":"Cyt_C_Oxase_1"}]},{"database":"PANTHER","id":"PTHR10422","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10422:SF18","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00115","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01165","properties":[{"key":"EntryName","value":"CYCOXIDASEI"}]},{"database":"SUPFAM","id":"SSF81442","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit I-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50855","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"TLSLLIRIHLMHSGSGFLVTGTLYNAVVTAHAFLMIFFMVMPVLIGGFGNWLVPMLIPAPDLGLARMNNLSFWLLPHSLVFLLVSTLTDTAVGTGWTLYPPLSSLEGHHSPCVDEAIFSLHMSGIASIFASVNFITTIKHARGPHKPLVALPLFVAAIGTTSILLLLSVPVLAGALTMLITDRNINTAFFDPEGGGDPVLFQHLFWFFG","length":209,"molWeight":22580,"crc64":"336D248DD9D2F565","md5":"FEB904D43C1228B9512CE4658C526915"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00094A9160"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2P1L4D1","uniProtkbId":"A0A2P1L4D1_TESTE","entryAudit":{"firstPublicDate":"2018-05-23","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2018-05-23","entryVersion":27,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12663.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012596"}],"value":"ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012596"}],"value":"2.5.1.87"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53008"},{"database":"Rhea","id":"RHEA-COMP:19494"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:128769"},{"database":"ChEBI","id":"CHEBI:136960"},{"database":"ChEBI","id":"CHEBI:175763"}],"ecNumber":"2.5.1.87","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047353"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004922"}],"value":"Protein modification; protein glycosylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004586"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005432"}],"value":"Belongs to the UPP synthase family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"29501422","citationType":"journal article","authors":["Gorbushin A.M."],"citationCrossReferences":[{"database":"PubMed","id":"29501422"}],"title":"Immune repertoire in the transcriptome of Littorina littorea reveals new trends in lophotrochozoan proto-complement evolution.","publicationDate":"2018","journal":"Dev. Comp. Immunol.","firstPage":"250","lastPage":"263","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12663.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MG596908","properties":[{"key":"ProteinId","value":"AVP12663.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A2P1L4D1","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00378","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:1904423","properties":[{"key":"GoTerm","value":"C:dehydrodolichyl diphosphate synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045547","properties":[{"key":"GoTerm","value":"F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0043048","properties":[{"key":"GoTerm","value":"P:dolichyl monophosphate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.1180.10","properties":[{"key":"EntryName","value":"Decaprenyl diphosphate synthase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR038887","properties":[{"key":"EntryName","value":"Nus1/NgBR"}]},{"database":"InterPro","id":"IPR036424","properties":[{"key":"EntryName","value":"UPP_synth-like_sf"}]},{"database":"PANTHER","id":"PTHR21528","properties":[{"key":"EntryName","value":"DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21528:SF0","properties":[{"key":"EntryName","value":"DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64005","properties":[{"key":"EntryName","value":"Undecaprenyl diphosphate synthase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIAAIVLRVLHYILTLGLFLRNFVYNIPNAYLSFYKKNNVSSIRNDAKLLKKLPMHLGFVIVENDYTFRDIANLIVWSVAMGISYISVYDINGDIKRNSFLLQKEIKRSKQETFASEDSKFEISLSLSESEEICNEEELSFKQAQVQLLAADDGRLNLVKTAQNYCQLVTTNQYQLEDIVPNNVDSHLQKLFKLPDPDLVILLGHINSLLGYMPWQVRLSEILNLPLIKGVNYKSYLSLIYTYGKTIQRFGT","length":252,"molWeight":28969,"crc64":"ECCB349DD4EC40CE","md5":"02F83B7D27E00E53E4A6D88293E22FFB"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"uniParcId":"UPI000D20E7F4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2P1L4E0","uniProtkbId":"A0A2P1L4E0_TESTE","entryAudit":{"firstPublicDate":"2018-05-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-05-23","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12664.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041077"}],"value":"Charged multivesicular body protein 7"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041629"}],"value":"Chromatin-modifying protein 7"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004259"}],"value":"Nucleus envelope","id":"SL-0178"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006190"}],"value":"Belongs to the SNF7 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"CHMP7 N-terminal winged helix","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF25880"}]},{"type":"Domain","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"CHMP7 winged helix","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF25239"}]},{"type":"Region","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"29501422","citationType":"journal article","authors":["Gorbushin A.M."],"citationCrossReferences":[{"database":"PubMed","id":"29501422"}],"title":"Immune repertoire in the transcriptome of Littorina littorea reveals new trends in lophotrochozoan proto-complement evolution.","publicationDate":"2018","journal":"Dev. Comp. Immunol.","firstPage":"250","lastPage":"263","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12664.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MG596909","properties":[{"key":"ProteinId","value":"AVP12664.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A2P1L4E0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009898","properties":[{"key":"GoTerm","value":"C:cytoplasmic side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000815","properties":[{"key":"GoTerm","value":"C:ESCRT III complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005771","properties":[{"key":"GoTerm","value":"C:multivesicular body"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0032511","properties":[{"key":"GoTerm","value":"P:late endosome to vacuole transport via multivesicular body sorting pathway"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006900","properties":[{"key":"GoTerm","value":"P:vesicle budding from membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"6.10.250.1710","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.1060","properties":[{"key":"EntryName","value":"ESAT-6-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR057471","properties":[{"key":"EntryName","value":"CHMP7_WHD"}]},{"database":"InterPro","id":"IPR005024","properties":[{"key":"EntryName","value":"Snf7_fam"}]},{"database":"InterPro","id":"IPR058720","properties":[{"key":"EntryName","value":"WHD_CHMP7_1st"}]},{"database":"PANTHER","id":"PTHR22761","properties":[{"key":"EntryName","value":"CHARGED MULTIVESICULAR BODY PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22761:SF21","properties":[{"key":"EntryName","value":"CHARGED MULTIVESICULAR BODY PROTEIN 7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03357","properties":[{"key":"EntryName","value":"Snf7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25239","properties":[{"key":"EntryName","value":"WHD_CHMP7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25880","properties":[{"key":"EntryName","value":"WHD_CHMP7_1st"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAENTESDGFPPEWQDDQRMAVLFAAFRDKSLNPHSWNQKMNFWKTLITKKCKQKGTCSLSLDNLASTFERKGKSPKCLDLVVQEMIRLKKLRNLSDIEASGSSKGWLSWSLSVVKKPISWSFSRLLGSPNTNTEKLVYLPDLLQDKCNELLRQHYRCIEHDISDHILELEELKSKYQQLFPTDIDLHVVLQQLQTDRKILLQQINDKEALVKFCKEGEKEVKPIEDIELSLYNIIKVQRDLEKQIESLSEKCDSHTQDAKVYVREGKKKMALQCLRRRKAVGKVIDKKSHSLDILHTMLLKIQDAANNEMVLKAYKAGVSALKSTSQTVNIDKVENVMDDLQEVLEDQDEINRTLSAGEITLDDSSVADLESELDAMLNEDQQQTDIDDLADLMSNLETKDAEYPNIPTTSPVKRMKGGNSNIAMEKS","length":429,"molWeight":49002,"crc64":"26DB9E1F0EAED7D2","md5":"33170AD13311209003A3A1CDA333D00F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI000D22BED0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2P1L4E1","uniProtkbId":"A0A2P1L4E1_TESTE","entryAudit":{"firstPublicDate":"2018-05-23","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-05-23","entryVersion":30,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12665.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049739"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"value":"mRNA cap guanine-N(7) methyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011926"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"value":"2.1.1.56"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032772"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"value":"mRNA (guanine-N(7))-methyltransferase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"value":"mRNA cap methyltransferase"}}]},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:67008"},{"database":"Rhea","id":"RHEA-COMP:17166"},{"database":"Rhea","id":"RHEA-COMP:17167"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:156461"},{"database":"ChEBI","id":"CHEBI:167617"}],"ecNumber":"2.1.1.56","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044712"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"value":"Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"MRNA cap 0 methyltransferase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51562"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:33699"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"ligand":{"name":"mRNA","id":"ChEBI:CHEBI:33699"}},{"type":"Binding site","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-1"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-1"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-1"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Site","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"mRNA cap binding","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}]},{"type":"Site","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"mRNA cap binding","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}]},{"type":"Site","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"mRNA cap binding","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}]},{"type":"Site","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"mRNA cap binding","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}]},{"type":"Site","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"mRNA cap binding","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}]},{"type":"Site","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"mRNA cap binding","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR028762-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00895"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022603"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023042"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"id":"KW-0506","category":"Biological process","name":"mRNA capping"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022664"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022691"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR028762"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"29501422","citationType":"journal article","authors":["Gorbushin A.M."],"citationCrossReferences":[{"database":"PubMed","id":"29501422"}],"title":"Immune repertoire in the transcriptome of Littorina littorea reveals new trends in lophotrochozoan proto-complement evolution.","publicationDate":"2018","journal":"Dev. Comp. Immunol.","firstPage":"250","lastPage":"263","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12665.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MG596910","properties":[{"key":"ProteinId","value":"AVP12665.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A2P1L4E1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004482","properties":[{"key":"GoTerm","value":"F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0046500","properties":[{"key":"GoTerm","value":"P:S-adenosylmethionine metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd02440","properties":[{"key":"EntryName","value":"AdoMet_MTases"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.150:FF:000093","properties":[{"key":"EntryName","value":"mRNA cap guanine-N7 methyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004971","properties":[{"key":"EntryName","value":"mRNA_G-N7_MeTrfase_dom"}]},{"database":"InterPro","id":"IPR016899","properties":[{"key":"EntryName","value":"mRNA_G-N7_MeTrfase_euk"}]},{"database":"InterPro","id":"IPR039753","properties":[{"key":"EntryName","value":"RG7MT1"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"PANTHER","id":"PTHR12189:SF2","properties":[{"key":"EntryName","value":"MRNA CAP GUANINE-N7 METHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12189","properties":[{"key":"EntryName","value":"MRNA GUANINE-7- METHYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03291","properties":[{"key":"EntryName","value":"mRNA_G-N7_MeTrfase"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF028762","properties":[{"key":"EntryName","value":"ABD1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51562","properties":[{"key":"EntryName","value":"RNA_CAP0_MT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MENNGNKVVESEGGESSSKAEGGKDGGEDLTGTVAKHYNELQEAGRQSRALSRIYHMRNFNNWTKSILIGDTLDKIRESDRNKKIVVLDLCSGKGGDLLKWKKGGIDQLVCADIAATSVEQSEARYKDMTERSRNERYGPRLYEAEFIAADCTKEKLTDKYKDPNLQFDLTSCQFSFHYSFESEQQADIMLQNACSSLKPGGYFIGTTPNSNELVKRLRASEDNSFGNDVYRVTFPDPDESSFPLFGAKYNFHLEGVVDCPEFLVYFPLLEKMAEKYDMKLIEKKTFADFYSEKVQRSDAKKLLNKMSALETYPTNDELVGKDADDYIHASQFISTLESQPDDRGHSSRRPVKIGTLSKAEWEAITVYLVFVFQKMGGEEKEVTSPRRRKHDDEEEETEPSEKRAKNSD","length":409,"molWeight":46465,"crc64":"9E77829596C25664","md5":"0ECC1AD9A2CFC8A7945754DBAC97CAF0"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":1,"Binding site":9,"Site":6},"uniParcId":"UPI000D203F1B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A411DES6","uniProtkbId":"A0A411DES6_TESTE","entryAudit":{"firstPublicDate":"2019-05-08","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-05-08","entryVersion":24,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18420.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18420.1"}],"value":"MASP-related molecule Type 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18420.1"}],"value":"MReM-1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.","ecNumber":"3.4.21.1","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10078"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}],"value":"Belongs to the peptidase S1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":1008,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5019094628"},{"type":"Domain","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"CUB","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS01180"}]},{"type":"Domain","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"CUB","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS01180"}]},{"type":"Domain","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"CUB","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS01180"}]},{"type":"Domain","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":503,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":542,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":546,"modifier":"EXACT"},"end":{"value":636,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":640,"modifier":"EXACT"},"end":{"value":718,"modifier":"EXACT"}},"description":"Ig-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50835"}]},{"type":"Domain","location":{"start":{"value":758,"modifier":"EXACT"},"end":{"value":1003,"modifier":"EXACT"}},"description":"Peptidase S1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50240"}]},{"type":"Active site","location":{"start":{"value":800,"modifier":"EXACT"},"end":{"value":800,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}]},{"type":"Active site","location":{"start":{"value":854,"modifier":"EXACT"},"end":{"value":854,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}]},{"type":"Active site","location":{"start":{"value":955,"modifier":"EXACT"},"end":{"value":955,"modifier":"EXACT"}},"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}]},{"type":"Disulfide bond","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":532,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":785,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}]},{"type":"Disulfide bond","location":{"start":{"value":951,"modifier":"EXACT"},"end":{"value":979,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00114"}],"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022825"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00274"}],"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022659"}],"id":"KW-0768","category":"Domain","name":"Sushi"}],"references":[{"referenceNumber":1,"citation":{"id":"30682446","citationType":"journal article","authors":["Gorbushin A.M."],"citationCrossReferences":[{"database":"PubMed","id":"30682446"},{"database":"DOI","id":"10.1016/j.dci.2019.01.010"}],"title":"Derivatives of the lectin complement pathway in Lophotrochozoa.","publicationDate":"2019","journal":"Dev. Comp. Immunol.","firstPage":"35","lastPage":"58","volume":"94"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18420.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MK153126","properties":[{"key":"ProteinId","value":"QBA18420.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A411DES6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00041","properties":[{"key":"EntryName","value":"CUB"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00190","properties":[{"key":"EntryName","value":"Tryp_SPc"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.290:FF:000013","properties":[{"key":"EntryName","value":"Membrane frizzled-related protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.120.290:FF:000005","properties":[{"key":"EntryName","value":"Procollagen C-endopeptidase enhancer 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.10.10:FF:000120","properties":[{"key":"EntryName","value":"Putative serine protease"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000699","properties":[{"key":"EntryName","value":"Uncharacterized protein, isoform C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.60.120.290","properties":[{"key":"EntryName","value":"Spermadhesin, CUB domain"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"2.40.10.10","properties":[{"key":"EntryName","value":"Trypsin-like serine proteases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000859","properties":[{"key":"EntryName","value":"CUB_dom"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR007110","properties":[{"key":"EntryName","value":"Ig-like_dom"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR003599","properties":[{"key":"EntryName","value":"Ig_sub"}]},{"database":"InterPro","id":"IPR003598","properties":[{"key":"EntryName","value":"Ig_sub2"}]},{"database":"InterPro","id":"IPR009003","properties":[{"key":"EntryName","value":"Peptidase_S1_PA"}]},{"database":"InterPro","id":"IPR001314","properties":[{"key":"EntryName","value":"Peptidase_S1A"}]},{"database":"InterPro","id":"IPR035914","properties":[{"key":"EntryName","value":"Sperma_CUB_dom_sf"}]},{"database":"InterPro","id":"IPR001254","properties":[{"key":"EntryName","value":"Trypsin_dom"}]},{"database":"InterPro","id":"IPR018114","properties":[{"key":"EntryName","value":"TRYPSIN_HIS"}]},{"database":"InterPro","id":"IPR033116","properties":[{"key":"EntryName","value":"TRYPSIN_SER"}]},{"database":"PANTHER","id":"PTHR24255","properties":[{"key":"EntryName","value":"COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24255:SF28","properties":[{"key":"EntryName","value":"ST14 TRANSMEMBRANE SERINE PROTEASE MATRIPTASE B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00431","properties":[{"key":"EntryName","value":"CUB"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00008","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13927","properties":[{"key":"EntryName","value":"Ig_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00089","properties":[{"key":"EntryName","value":"Trypsin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00722","properties":[{"key":"EntryName","value":"CHYMOTRYPSIN"}]},{"database":"SMART","id":"SM00042","properties":[{"key":"EntryName","value":"CUB"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00409","properties":[{"key":"EntryName","value":"IG"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00408","properties":[{"key":"EntryName","value":"IGc2"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00020","properties":[{"key":"EntryName","value":"Tryp_SPc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF49854","properties":[{"key":"EntryName","value":"Spermadhesin, CUB domain"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF50494","properties":[{"key":"EntryName","value":"Trypsin-like serine proteases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01180","properties":[{"key":"EntryName","value":"CUB"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50835","properties":[{"key":"EntryName","value":"IG_LIKE"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50240","properties":[{"key":"EntryName","value":"TRYPSIN_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00134","properties":[{"key":"EntryName","value":"TRYPSIN_HIS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00135","properties":[{"key":"EntryName","value":"TRYPSIN_SER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAEYKLLVILLGLQTYQISQCFNLDDETETFLDCGGHLVAGEGYFESPGFPDYYPNDLDCTWTITTSLGDRVHIFSKYFMIENQEQCLWDYVEIIENGNDSSIPWKYCGNEVIDFKSTSNSVSIYFHTDESTNGVGFKFKYTVIRKVESSSNYCNGTVKHEGYLTSPNHPMKYPSNTNCYYNIQAPIGYTIYLKFNSFHVEVEPCLFDKVTVYEVTPIGKSNKISLCGRNTPSPIHSKTNKLTLILNTDSSQQFYGFNISVLFIRPPTMLPLDTTDMLPLDTEQTMSTSTLSIAPNTSISSTIDSSDNTMATTPVSLYDTDCSYVVRNETGVISSPGYPAHYDSNKYCSILLQSNKNSSIVIQFTNFDVEGSHECMYDYVVLIPDKDGDRRVLLCGRRLDKKIYTFASETLQVLFRRVLLCGRRLDKKIYTFASETLQVLFRSDKSVHGLGFAANYFITPLDNDKSCALVCENGAECNKNFTADNIPIWSCICPPNFYGELCEKKRTTCFDLNCHNNGQCIASEDNEVHCQCLHGFTGHFCEIEREDVFRFIKKPVNTTVARGSSVLFECGVNEPNADIMWLLRDRILSIDDHTHGINIYPGGVLVIPDIKEEHEGQYTCAARSGDNWIEVSAWLSLVGPCHLRVTKAPKNVTRDDGATALFECLVPDADSIVPASGTRHSNRAVAPSSQQKEKILVNNYLMIENLMETDAGVYTCVAVGQNGCFAKPSAKLIIQTTGHNEFCGRPIVSASTDKKFRIASGREAEDGSAPWHVIIWESVHGLAYCGGSLVNEKWVLTAAHCVTQFEKYFEYKFDKSLIEMFIGTRNCKGRGGISRKIKDYIIYPTFNGTDFNNDLALFELDEPVTFGDLVMPICLEREVFTSELLKSGKAGIVTGCGNRYERGRPPTYLHEVTIPYVPRELCTESAKAVNASFSDYMICAGYARSMQGDACTGDSGGPYSMKFNGRWILVGIVSWGVGCDRENQYGYYTHISKYYDWIMSITTNNQRV","length":1008,"molWeight":113070,"crc64":"B2BAC07BC7D53C5C","md5":"FFB65446150780327E104DCFBDE14AAA"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":8,"Active site":3,"Disulfide bond":5},"uniParcId":"UPI00101802FF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"O02419","uniProtkbId":"O02419_TESTE","entryAudit":{"firstPublicDate":"1997-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1997-07-01","entryVersion":101,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC03160.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"value":"Elongation factor 1-alpha"}},"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"value":"This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007249"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"value":"Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Tr-type G","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51722"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC03160.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC03160.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022768"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"id":"KW-0251","category":"Molecular function","name":"Elongation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000325"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"}],"references":[{"referenceNumber":1,"citation":{"id":"9287423","citationType":"journal article","authors":["Regier J.C.","Shultz J.W."],"citationCrossReferences":[{"database":"PubMed","id":"9287423"}],"title":"Molecular phylogeny of the major arthropod groups indicates polyphyly of crustaceans and a new hypothesis for the origin of hexapods.","publicationDate":"1997","journal":"Mol. Biol. Evol.","firstPage":"902","lastPage":"913","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAC03160.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U90061","properties":[{"key":"ProteinId","value":"AAC03160.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003746","properties":[{"key":"GoTerm","value":"F:translation elongation factor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd01883","properties":[{"key":"EntryName","value":"EF1_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd03693","properties":[{"key":"EntryName","value":"EF1_alpha_II"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd03705","properties":[{"key":"EntryName","value":"EF1_alpha_III"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.30.10:FF:000003","properties":[{"key":"EntryName","value":"Elongation factor 1-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.30.10:FF:000005","properties":[{"key":"EntryName","value":"Elongation factor 1-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.30.10","properties":[{"key":"EntryName","value":"Translation factors"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR004161","properties":[{"key":"EntryName","value":"EFTu-like_2"}]},{"database":"InterPro","id":"IPR031157","properties":[{"key":"EntryName","value":"G_TR_CS"}]},{"database":"InterPro","id":"IPR054696","properties":[{"key":"EntryName","value":"GTP-eEF1A_C"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR000795","properties":[{"key":"EntryName","value":"T_Tr_GTP-bd_dom"}]},{"database":"InterPro","id":"IPR050100","properties":[{"key":"EntryName","value":"TRAFAC_GTPase_members"}]},{"database":"InterPro","id":"IPR009000","properties":[{"key":"EntryName","value":"Transl_B-barrel_sf"}]},{"database":"InterPro","id":"IPR009001","properties":[{"key":"EntryName","value":"Transl_elong_EF1A/Init_IF2_C"}]},{"database":"InterPro","id":"IPR004539","properties":[{"key":"EntryName","value":"Transl_elong_EF1A_euk/arc"}]},{"database":"NCBIfam","id":"TIGR00483","properties":[{"key":"EntryName","value":"EF-1_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23115","properties":[{"key":"EntryName","value":"TRANSLATION FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22594","properties":[{"key":"EntryName","value":"GTP-eEF1A_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00009","properties":[{"key":"EntryName","value":"GTP_EFTU"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03144","properties":[{"key":"EntryName","value":"GTP_EFTU_D2"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00315","properties":[{"key":"EntryName","value":"ELONGATNFCT"}]},{"database":"SUPFAM","id":"SSF50465","properties":[{"key":"EntryName","value":"EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50447","properties":[{"key":"EntryName","value":"Translation proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00301","properties":[{"key":"EntryName","value":"G_TR_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51722","properties":[{"key":"EntryName","value":"G_TR_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LDKLKAERERGITIDIALWKFETERYYVTIIDAPGHRDFIKNMITGTSQADCAVLIIAAGTGEFEAGISKDGQTREHALLAYTLGVKQLIIGVNKMDNTEPPYSETRFNEITKEVSGYIKKIGYNPKAVGFVPISGYNGDNMLEKSPKMPWYKGWKVEQKDDKGNASTVTGDTLTQALDSIQPPKRPTDKALRLPLQDVYKIGGIGTVPVGRVETGVXKPGMVISFGPTMITTECKSVEMHXESXTEGLPGDNVGFNVKNISVKDIKRGFVASDSKNDPAKGAKSFNAQVIILNHPGEIHAGYSPVLDCHTAHIACKFNELLEKIDRRSAKKMEDSPKMVKSGDAAIVNLIPSKPMCVEAFTDY","length":364,"molWeight":39886,"crc64":"C6F2AE209610A8D7","md5":"BB126B36CCD309FCB7D4032C135C3AD0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0000081FAB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2P1L4C4","uniProtkbId":"A0A2P1L4C4_TESTE","entryAudit":{"firstPublicDate":"2018-05-23","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2018-05-23","entryVersion":23,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12662.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12662.1"}],"value":"Solute carrier family 25 member 46"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004374"}],"value":"Mitochondrion outer membrane","id":"SL-0172"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004374"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006375"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000488"}],"value":"Belongs to the mitochondrial carrier (TC 2.A.29) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Repeat","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"Solcar","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00282"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00282"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022787"}],"id":"KW-1000","category":"Cellular component","name":"Mitochondrion outer membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00282"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000488"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"29501422","citationType":"journal article","authors":["Gorbushin A.M."],"citationCrossReferences":[{"database":"PubMed","id":"29501422"}],"title":"Immune repertoire in the transcriptome of Littorina littorea reveals new trends in lophotrochozoan proto-complement evolution.","publicationDate":"2018","journal":"Dev. Comp. Immunol.","firstPage":"250","lastPage":"263","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12662.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MG596907","properties":[{"key":"ProteinId","value":"AVP12662.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A2P1L4C4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005741","properties":[{"key":"GoTerm","value":"C:mitochondrial outer membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0090149","properties":[{"key":"GoTerm","value":"P:mitochondrial membrane fission"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.50.40.10","properties":[{"key":"EntryName","value":"Mitochondrial carrier domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR023395","properties":[{"key":"EntryName","value":"MCP_dom_sf"}]},{"database":"InterPro","id":"IPR018108","properties":[{"key":"EntryName","value":"MCP_transmembrane"}]},{"database":"InterPro","id":"IPR039158","properties":[{"key":"EntryName","value":"SLC25A46"}]},{"database":"PANTHER","id":"PTHR21252:SF2","properties":[{"key":"EntryName","value":"MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21252","properties":[{"key":"EntryName","value":"TB1 PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00153","properties":[{"key":"EntryName","value":"Mito_carr"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF103506","properties":[{"key":"EntryName","value":"Mitochondrial carrier"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50920","properties":[{"key":"EntryName","value":"SOLCAR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGTNVTYDSFSMSERYSPKDSSRRNQLDDEIRYRQYLEAEQSNKPVPSQPDQFQKAAGFAIGLSSVFAEQILSHPCKVIRRQCQVHHNGEWYHLTPFTLIQVLINRYRHQGMGTLWKGLGSVFVVSGFVMISDTVISEITPLPKEVSRHSSIKKNLQNVLLKGLTFALATPLFASSLIETIQSDIASERPGVFDCIKEAATRIMGWGMPQTTRLLPIWKLVLPTAIFRVTQYVICSVAQYTVVSSIRSDQLEAGESSETSSSMSQTLYDEYFPDLIGTFSGAIIADIALYPLETVLNRLYIQGTRTIIDNMDTGFGVIPINTGYEGFINCFQSIVIEEGLQGLYRGFGALLLQYAIHAAILRMARILFVKLTESYRPKQRPSLPPISPNPALSTSDSKYSPYRPPTNPNSPSYYQYRDK","length":419,"molWeight":47060,"crc64":"11A2CD908E2452D5","md5":"7FEE1E9E557F0275499D3DC3AA1E4B7B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Repeat":1,"Region":2,"Compositional bias":2},"uniParcId":"UPI000D227035"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A2P1L4D2","uniProtkbId":"A0A2P1L4D2_TESTE","entryAudit":{"firstPublicDate":"2018-05-23","lastAnnotationUpdateDate":"2025-10-08","lastSequenceUpdateDate":"2018-05-23","entryVersion":15,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12666.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12666.1"}],"value":"T-cell immunomodulatory protein"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004479"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006496"}],"value":"Belongs to the TIP family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5015199637"},{"type":"Transmembrane","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":585,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":555,"modifier":"EXACT"}},"description":"T-cell immunomodulatory protein TIP C2","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF23122"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"29501422","citationType":"journal article","authors":["Gorbushin A.M."],"citationCrossReferences":[{"database":"PubMed","id":"29501422"}],"title":"Immune repertoire in the transcriptome of Littorina littorea reveals new trends in lophotrochozoan proto-complement evolution.","publicationDate":"2018","journal":"Dev. Comp. Immunol.","firstPage":"250","lastPage":"263","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AVP12666.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MG596911","properties":[{"key":"ProteinId","value":"AVP12666.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A2P1L4D2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"2.130.10.130","properties":[{"key":"EntryName","value":"Integrin alpha, N-terminal"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR057089","properties":[{"key":"EntryName","value":"C2_TIP"}]},{"database":"InterPro","id":"IPR028994","properties":[{"key":"EntryName","value":"Integrin_alpha_N"}]},{"database":"InterPro","id":"IPR024881","properties":[{"key":"EntryName","value":"Tip"}]},{"database":"PANTHER","id":"PTHR13412:SF0","properties":[{"key":"EntryName","value":"T-CELL IMMUNOMODULATORY PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13412","properties":[{"key":"EntryName","value":"T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23122","properties":[{"key":"EntryName","value":"C2_ITFG1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF69318","properties":[{"key":"EntryName","value":"Integrin alpha N-terminal domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSQNEMMNVFLSLLAFFCIISNECTFASFSDTSSGIFGLTSQGLIAAFGDFNADKATDVFILSDDAKTVQLIFGKTEKIDASYSQEELISSKQNNDSYMVSLIPSDFNGDSIMDLLVTRRKDGDKSGPLQVLIYWGTTKSDLVEDEPLVLTELFKDQPAILDVNSDMIPDLLAETNDGERSYWIFNSNQNYTTIKVENGTSQSSLPPLYVPQSSAFLDFDMDLTADLITVSSGKSSKLQFEIWLNKKGVLVWDQTIETPTEIKIFGQPSFLDMNSDHSIDIVLPGCLDDECSKSVIYVYSKEKWCKLDVKFKDNNNLWGFTPTSLHPLLDVPLSLRMGDLNLDGYPDALTILSSRNKTEVQKEVVMKNVPCGSCDGFSRTFEMDFIGASKSSSNPVLVAFFDIGENGVLDVLISNYDGKNSQLVALSQTFTEDAYFVKVMVLSGLCKSECHGHQRYGVNQVGPAIKYETVNSNGDPQIGIASQLVQSAYFSLQLPFTVFGLGQTPNFVDKLVVGIPYPHGAKSRNKEFTSIIPNSRLVITPFPVDEPSSWSNKLFITPSKLVLLTGASLLGVCGFIAIIVGILHWRDRAEDKREKLQDSHKFHFDAM","length":607,"molWeight":67268,"crc64":"8B4862C6FEC6D0DA","md5":"81E29FB45538517DF092D005F14E8B1D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":1},"uniParcId":"UPI000D20E726"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A411DEQ6","uniProtkbId":"A0A411DEQ6_TESTE","entryAudit":{"firstPublicDate":"2019-05-08","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-05-08","entryVersion":14,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18422.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18422.1"}],"value":"C1q-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18422.1"}],"value":"C1qL"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5019036257"},{"type":"Domain","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"C1q","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50871"}]},{"type":"Region","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023119"}],"id":"KW-0176","category":"Domain","name":"Collagen"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"30682446","citationType":"journal article","authors":["Gorbushin A.M."],"citationCrossReferences":[{"database":"PubMed","id":"30682446"},{"database":"DOI","id":"10.1016/j.dci.2019.01.010"}],"title":"Derivatives of the lectin complement pathway in Lophotrochozoa.","publicationDate":"2019","journal":"Dev. Comp. Immunol.","firstPage":"35","lastPage":"58","volume":"94"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18422.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MK153128","properties":[{"key":"ProteinId","value":"QBA18422.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A411DEQ6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"Gene3D","id":"2.60.120.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001073","properties":[{"key":"EntryName","value":"C1q_dom"}]},{"database":"InterPro","id":"IPR050392","properties":[{"key":"EntryName","value":"Collagen/C1q_domain"}]},{"database":"InterPro","id":"IPR008983","properties":[{"key":"EntryName","value":"Tumour_necrosis_fac-like_dom"}]},{"database":"PANTHER","id":"PTHR15427:SF52","properties":[{"key":"EntryName","value":"C1Q DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15427","properties":[{"key":"EntryName","value":"EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00386","properties":[{"key":"EntryName","value":"C1q"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00007","properties":[{"key":"EntryName","value":"COMPLEMNTC1Q"}]},{"database":"SMART","id":"SM00110","properties":[{"key":"EntryName","value":"C1Q"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49842","properties":[{"key":"EntryName","value":"TNF-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50871","properties":[{"key":"EntryName","value":"C1Q"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMIKSDICMLMLVVMTMVEGRRYPRKNRNKDKEQAQRDEAEPVCELEVACRGEKNIPITLPIRGAKGPQGKNGQKGEPGDAGIPGIPGREGRSTPPIIRVAFFVGLQENQGPVKENSDLLFDKVITNVGNVFNPDTGRFTATHNGTYQFNVVVAAQGRQRAAVNLVRNGEMIATVWAESIPYWASASNTAILKLKGGDQVWLVLLSRAPYIHGYMYSTFSGHLLFPDKK","length":229,"molWeight":25272,"crc64":"3B76763375CB3247","md5":"62FC0234D5DE1BE2A6A869AA1BEB2D8C"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"Region":1},"uniParcId":"UPI00101747D1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A411DEU4","uniProtkbId":"A0A411DEU4_TESTE","entryAudit":{"firstPublicDate":"2019-05-08","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2019-05-08","entryVersion":14,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Testudinalia testudinalis","commonName":"Tortoise-shell limpet","synonyms":["Tectura testudinalis"],"taxonId":2126142,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18421.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Gastropoda","Patellogastropoda","Lottioidea","Lottiidae","Testudinalia"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18421.1"}],"value":"Type 2 C1q domain-containing protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18421.1"}],"value":"C1qDC2"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Domain","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"C1q","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50871"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"30682446","citationType":"journal article","authors":["Gorbushin A.M."],"citationCrossReferences":[{"database":"PubMed","id":"30682446"},{"database":"DOI","id":"10.1016/j.dci.2019.01.010"}],"title":"Derivatives of the lectin complement pathway in Lophotrochozoa.","publicationDate":"2019","journal":"Dev. Comp. Immunol.","firstPage":"35","lastPage":"58","volume":"94"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QBA18421.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MK153127","properties":[{"key":"ProteinId","value":"QBA18421.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A411DEU4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"Gene3D","id":"2.60.120.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001073","properties":[{"key":"EntryName","value":"C1q_dom"}]},{"database":"InterPro","id":"IPR050822","properties":[{"key":"EntryName","value":"Cerebellin_Synaptic_Org"}]},{"database":"InterPro","id":"IPR008983","properties":[{"key":"EntryName","value":"Tumour_necrosis_fac-like_dom"}]},{"database":"PANTHER","id":"PTHR22923:SF116","properties":[{"key":"EntryName","value":"C1Q DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22923","properties":[{"key":"EntryName","value":"CEREBELLIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00386","properties":[{"key":"EntryName","value":"C1q"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00007","properties":[{"key":"EntryName","value":"COMPLEMNTC1Q"}]},{"database":"SMART","id":"SM00110","properties":[{"key":"EntryName","value":"C1Q"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49842","properties":[{"key":"EntryName","value":"TNF-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50871","properties":[{"key":"EntryName","value":"C1Q"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTDKTTAVVKGLMHLLHFISKTTISGNMLALLTVCFIGGTTAMWPAFPFQLIPSAQLTPGLSPTHHQPREPLQAESVSESVRTCLCQNEIQILDARLRSEHTLLEKFHTKLTDLSNVVYNLRATVIEKDIPKRETAEQAFGPGFGQHVAFTARTRTNKVFLGPTDTVVFDEATVNNGHAYDPLTGVFTAPFNGVYHFSSTILSGFNATIETMFVLNGEEVGRMFSGAFLSRGSGSNSILLNLKERDEVSVNVFYGNGNYVHGGWSTFMGYLISTIY","length":276,"molWeight":30362,"crc64":"684755F520302376","md5":"11B61B4E22D45E21BDDA07AC2F2BC0B0"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI001018ED0F"}}]}