{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8D7ZEN4","uniProtkbId":"A0A8D7ZEN4_9MOLL","entryAudit":{"firstPublicDate":"2022-01-19","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2022-01-19","entryVersion":13,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG4719767.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040276"}],"value":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038968"}],"value":"1.1.1.141"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039060"}],"value":"1.1.1.232"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042026"}],"value":"Eicosanoid/docosanoid dehydrogenase [NAD(+)]"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041812"}],"value":"Prostaglandin dehydrogenase 1"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045705"}],"value":"Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48640"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:78836"},{"database":"ChEBI","id":"CHEBI:90697"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048144"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48641"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048144"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:23260"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57409"},{"database":"ChEBI","id":"CHEBI:57410"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"1.1.1.232","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049151"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:23261"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049151"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48952"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:90866"},{"database":"ChEBI","id":"CHEBI:90867"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048008"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48953"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048008"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41596"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:78325"},{"database":"ChEBI","id":"CHEBI:78329"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048140"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41597"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048140"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41572"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:67026"},{"database":"ChEBI","id":"CHEBI:78311"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048535"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41573"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048535"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41263"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57398"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:85072"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048611"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41264"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048611"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16477"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57397"},{"database":"ChEBI","id":"CHEBI:57401"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047325"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:16478"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047325"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11876"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57400"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:606564"}],"ecNumber":"1.1.1.141","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048739"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11877"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048739"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50128"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:132079"},{"database":"ChEBI","id":"CHEBI:132081"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048170"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50129"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048170"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50124"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:132079"},{"database":"ChEBI","id":"CHEBI:132080"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047672"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50125"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047672"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53588"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:133367"},{"database":"ChEBI","id":"CHEBI:137498"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048921"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53589"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048921"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53584"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:133367"},{"database":"ChEBI","id":"CHEBI:137497"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048393"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53585"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048393"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:49244"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:91000"},{"database":"ChEBI","id":"CHEBI:91001"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049188"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:49245"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049188"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006484"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000363"}],"value":"Belongs to the short-chain dehydrogenases/reductases (SDR) family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-380OV44TCU592","citationType":"submission","authors":["Leclere L."],"publicationDate":"APR-2021","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG4719767.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OD960291","properties":[{"key":"ProteinId","value":"CAG4719767.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A8D7ZEN4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0047034","properties":[{"key":"GoTerm","value":"F:15-hydroxyicosatetraenoate dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0016404","properties":[{"key":"GoTerm","value":"F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"FunFam","id":"3.40.50.720:FF:000149","properties":[{"key":"EntryName","value":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR002347","properties":[{"key":"EntryName","value":"SDR_fam"}]},{"database":"PANTHER","id":"PTHR44229","properties":[{"key":"EntryName","value":"15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR44229:SF4","properties":[{"key":"EntryName","value":"15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00106","properties":[{"key":"EntryName","value":"adh_short"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00081","properties":[{"key":"EntryName","value":"GDHRDH"}]},{"database":"PRINTS","id":"PR00080","properties":[{"key":"EntryName","value":"SDRFAMILY"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKVKGCSAVVTGGASGIGKAICQALVIQEAQVCVVDVNASEGKLAVEELKLLHGEENVLFVQADVSSEDELKGAFDKAKSTFGRIDVVVNNAGILEEKDWRACVNVNLVGVISGTMLALEHMGMESGGSGGSGGVIINMASAAGLTPMFHFMPTYCATKAAVLAHTRSWSTNPRCARQGIRFNAVCPGIVQTPITRGFTQEALINLSEEEMAAYHSAKKIEPSRVAEVVLELIEDDTKNGAIIDVRVEGARRVEYPTKL","length":259,"molWeight":27506,"crc64":"8CC2B811D2F9CF5D","md5":"F4E4EE736E7E7BE35AF672B3FF17B491"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":13,"SIMILARITY":1},"uniParcId":"UPI001C749521"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8D7ZEN5","uniProtkbId":"A0A8D7ZEN5_9MOLL","entryAudit":{"firstPublicDate":"2022-01-19","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2022-01-19","entryVersion":13,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG4719768.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040276"}],"value":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038968"}],"value":"1.1.1.141"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039060"}],"value":"1.1.1.232"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042026"}],"value":"Eicosanoid/docosanoid dehydrogenase [NAD(+)]"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041812"}],"value":"Prostaglandin dehydrogenase 1"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045705"}],"value":"Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48640"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:78836"},{"database":"ChEBI","id":"CHEBI:90697"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048144"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48641"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048144"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:23260"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57409"},{"database":"ChEBI","id":"CHEBI:57410"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"1.1.1.232","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049151"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:23261"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049151"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48952"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:90866"},{"database":"ChEBI","id":"CHEBI:90867"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048008"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48953"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048008"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41596"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:78325"},{"database":"ChEBI","id":"CHEBI:78329"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048140"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41597"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048140"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41572"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:67026"},{"database":"ChEBI","id":"CHEBI:78311"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048535"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41573"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048535"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41263"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57398"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:85072"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048611"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41264"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048611"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16477"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57397"},{"database":"ChEBI","id":"CHEBI:57401"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047325"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:16478"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047325"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11876"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57400"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:606564"}],"ecNumber":"1.1.1.141","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048739"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11877"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048739"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50128"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:132079"},{"database":"ChEBI","id":"CHEBI:132081"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048170"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50129"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048170"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50124"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:132079"},{"database":"ChEBI","id":"CHEBI:132080"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047672"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50125"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047672"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53588"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:133367"},{"database":"ChEBI","id":"CHEBI:137498"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048921"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53589"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048921"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53584"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:133367"},{"database":"ChEBI","id":"CHEBI:137497"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048393"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53585"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048393"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:49244"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:91000"},{"database":"ChEBI","id":"CHEBI:91001"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049188"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:49245"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049188"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006484"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000363"}],"value":"Belongs to the short-chain dehydrogenases/reductases (SDR) family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-380OV44TCU592","citationType":"submission","authors":["Leclere L."],"publicationDate":"APR-2021","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG4719768.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OD960292","properties":[{"key":"ProteinId","value":"CAG4719768.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A8D7ZEN5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0047034","properties":[{"key":"GoTerm","value":"F:15-hydroxyicosatetraenoate dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0016404","properties":[{"key":"GoTerm","value":"F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"FunFam","id":"3.40.50.720:FF:000149","properties":[{"key":"EntryName","value":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR002347","properties":[{"key":"EntryName","value":"SDR_fam"}]},{"database":"PANTHER","id":"PTHR44229","properties":[{"key":"EntryName","value":"15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR44229:SF4","properties":[{"key":"EntryName","value":"15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00106","properties":[{"key":"EntryName","value":"adh_short"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00081","properties":[{"key":"EntryName","value":"GDHRDH"}]},{"database":"PRINTS","id":"PR00080","properties":[{"key":"EntryName","value":"SDRFAMILY"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKIQGCVAVVTGGASGIGKATCQTLAAKGAKVCIVDVNGTQGKEAADELTLSYGAGNILFAQADISCQEQFKGAFDKVKSTFGRVDVLVNNAGIVNEVDWRTVVNVNLVGTISGTTLAVEYMGKKNGGSGGVIINIGSIIGLSPGDSHIFPTYASTKAAVIANTLSWSANPRLKEEGFRFNVVCPHIVDTPLIHNITQESYIDIAADIVAGFKAGEKIKPSSVAQVILELIEDDTKNGVIMKVTMEKVEQVEYPTPISSSGK","length":262,"molWeight":27477,"crc64":"A175E6EC0DF90E73","md5":"F59716F72A50A94F1A0F27127D3F91D4"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":13,"SIMILARITY":1},"uniParcId":"UPI001C797503"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8D7ZF44","uniProtkbId":"A0A8D7ZF44_9MOLL","entryAudit":{"firstPublicDate":"2022-01-19","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2022-01-19","entryVersion":13,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG4719770.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040276"}],"value":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038968"}],"value":"1.1.1.141"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039060"}],"value":"1.1.1.232"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042026"}],"value":"Eicosanoid/docosanoid dehydrogenase [NAD(+)]"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041812"}],"value":"Prostaglandin dehydrogenase 1"}}],"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045705"}],"value":"Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48640"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:78836"},{"database":"ChEBI","id":"CHEBI:90697"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048144"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48641"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048144"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:23260"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57409"},{"database":"ChEBI","id":"CHEBI:57410"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"1.1.1.232","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049151"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:23261"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049151"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48952"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:90866"},{"database":"ChEBI","id":"CHEBI:90867"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048008"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48953"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048008"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41596"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:78325"},{"database":"ChEBI","id":"CHEBI:78329"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048140"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41597"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048140"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41572"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:67026"},{"database":"ChEBI","id":"CHEBI:78311"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048535"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41573"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048535"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41263"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57398"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:85072"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048611"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41264"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048611"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16477"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57397"},{"database":"ChEBI","id":"CHEBI:57401"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047325"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:16478"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047325"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11876"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57400"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:606564"}],"ecNumber":"1.1.1.141","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048739"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11877"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048739"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50128"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:132079"},{"database":"ChEBI","id":"CHEBI:132081"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048170"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50129"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048170"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50124"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:132079"},{"database":"ChEBI","id":"CHEBI:132080"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047672"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50125"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047672"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53588"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:133367"},{"database":"ChEBI","id":"CHEBI:137498"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048921"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53589"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048921"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53584"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:133367"},{"database":"ChEBI","id":"CHEBI:137497"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048393"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53585"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048393"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:49244"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:91000"},{"database":"ChEBI","id":"CHEBI:91001"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049188"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:49245"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049188"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006484"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000363"}],"value":"Belongs to the short-chain dehydrogenases/reductases (SDR) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG4719770.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-380OV44TCU592","citationType":"submission","authors":["Leclere L."],"publicationDate":"APR-2021","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG4719770.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OD960294","properties":[{"key":"ProteinId","value":"CAG4719770.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A8D7ZF44","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0047034","properties":[{"key":"GoTerm","value":"F:15-hydroxyicosatetraenoate dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0016404","properties":[{"key":"GoTerm","value":"F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR002347","properties":[{"key":"EntryName","value":"SDR_fam"}]},{"database":"PANTHER","id":"PTHR44229","properties":[{"key":"EntryName","value":"15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR44229:SF4","properties":[{"key":"EntryName","value":"15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00106","properties":[{"key":"EntryName","value":"adh_short"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00081","properties":[{"key":"EntryName","value":"GDHRDH"}]},{"database":"PRINTS","id":"PR00080","properties":[{"key":"EntryName","value":"SDRFAMILY"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"KAICQALAVKGAKVCVVDVNATAGDTFAAELQISHGEETIVFVQADVSSQEQLEGAFDKAKSKLGRIDVVVNNAGFLDEKNWRACVNINLVGMISGTMLAVNHMGKEHGGNGGVIINIASKAGLVPGPCWFIPTYAATKAAIIAHTMSWSANPRCKQEGFRFNVVCPTVVDTPFTQRMNQDLVIGLTEEHFARNKSREKMKPSRVADVVLELIEDDNKNGAIIHLDTDKVEQLEYPKCVVPSFNFQF","length":247,"molWeight":26890,"crc64":"8BF3B7B8D72A339B","md5":"96AD0E5A2AEE14D68A5DCB87CCE358B6"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":13,"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI001C7580B9"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A8D7ZGB5","uniProtkbId":"A0A8D7ZGB5_9MOLL","entryAudit":{"firstPublicDate":"2022-01-19","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2022-01-19","entryVersion":13,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG4719769.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040276"}],"value":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038968"}],"value":"1.1.1.141"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039060"}],"value":"1.1.1.232"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042026"}],"value":"Eicosanoid/docosanoid dehydrogenase [NAD(+)]"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041812"}],"value":"Prostaglandin dehydrogenase 1"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045705"}],"value":"Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48640"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:78836"},{"database":"ChEBI","id":"CHEBI:90697"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048144"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48641"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048144"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:23260"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57409"},{"database":"ChEBI","id":"CHEBI:57410"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"1.1.1.232","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049151"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:23261"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049151"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48952"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:90866"},{"database":"ChEBI","id":"CHEBI:90867"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048008"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48953"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048008"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41596"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:78325"},{"database":"ChEBI","id":"CHEBI:78329"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048140"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41597"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048140"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41572"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:67026"},{"database":"ChEBI","id":"CHEBI:78311"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048535"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41573"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048535"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:41263"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57398"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:85072"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048611"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:41264"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048611"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16477"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57397"},{"database":"ChEBI","id":"CHEBI:57401"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047325"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:16478"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047325"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11876"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57400"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:606564"}],"ecNumber":"1.1.1.141","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048739"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11877"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048739"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50128"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:132079"},{"database":"ChEBI","id":"CHEBI:132081"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048170"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50129"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048170"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50124"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:132079"},{"database":"ChEBI","id":"CHEBI:132080"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047672"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:50125"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047672"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53588"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:133367"},{"database":"ChEBI","id":"CHEBI:137498"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048921"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53589"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048921"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53584"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:133367"},{"database":"ChEBI","id":"CHEBI:137497"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048393"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53585"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048393"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:49244"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:91000"},{"database":"ChEBI","id":"CHEBI:91001"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049188"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:49245"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049188"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006484"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000363"}],"value":"Belongs to the short-chain dehydrogenases/reductases (SDR) family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-380OV44TCU592","citationType":"submission","authors":["Leclere L."],"publicationDate":"APR-2021","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CAG4719769.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OD960293","properties":[{"key":"ProteinId","value":"CAG4719769.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A8D7ZGB5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0047034","properties":[{"key":"GoTerm","value":"F:15-hydroxyicosatetraenoate dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0016404","properties":[{"key":"GoTerm","value":"F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"FunFam","id":"3.40.50.720:FF:000149","properties":[{"key":"EntryName","value":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR002347","properties":[{"key":"EntryName","value":"SDR_fam"}]},{"database":"PANTHER","id":"PTHR44229","properties":[{"key":"EntryName","value":"15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR44229:SF4","properties":[{"key":"EntryName","value":"15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00106","properties":[{"key":"EntryName","value":"adh_short"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00081","properties":[{"key":"EntryName","value":"GDHRDH"}]},{"database":"PRINTS","id":"PR00080","properties":[{"key":"EntryName","value":"SDRFAMILY"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKIQGSVAVVTGGASGIGKAICQALAAEGAKVCIIDINAAQGRTFADELKHAHGEENILFARADVTSQEELEGVFDDAKDTLGPLDIVINNAGIVDEINWRSCVNVNLMGVISGTRLAVDYMSGKNGGSGGVIISTASVSGLVPEQYHFLPTYGATKAAVIAHTLSWSANPRCQREGIRINAVCPEGVNTPIVDVLKHPELLIDMSEELTRAFDRDLETMKPSRVAEVVMELILDDTKNGAIIHLTAEKAQQVRLECPDMINSFCTTVSASSELAIGHEK","length":280,"molWeight":29812,"crc64":"4F4504D49D4DBE65","md5":"6FBEDCE4E12FC0FEAE5170A6C7361918"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":13,"SIMILARITY":1},"uniParcId":"UPI001C7404B2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A023PPH0","uniProtkbId":"A0A023PPH0_9MOLL","entryAudit":{"firstPublicDate":"2014-07-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2014-07-09","entryVersion":44,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHX26700.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012543"}],"value":"chitin synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012543"}],"value":"2.4.1.16"}]}},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16637"},{"database":"Rhea","id":"RHEA-COMP:9593"},{"database":"Rhea","id":"RHEA-COMP:9595"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17029"},{"database":"ChEBI","id":"CHEBI:57705"},{"database":"ChEBI","id":"CHEBI:58223"}],"ecNumber":"2.4.1.16","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048014"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"value":"Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046329"}],"value":"Belongs to the chitin synthase family. Class IV subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":440,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":499,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":619,"modifier":"EXACT"},"end":{"value":639,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":741,"modifier":"EXACT"},"end":{"value":760,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":772,"modifier":"EXACT"},"end":{"value":797,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":821,"modifier":"EXACT"},"end":{"value":844,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1291,"modifier":"EXACT"},"end":{"value":1319,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1331,"modifier":"EXACT"},"end":{"value":1350,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1356,"modifier":"EXACT"},"end":{"value":1377,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1389,"modifier":"EXACT"},"end":{"value":1408,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1644,"modifier":"EXACT"},"end":{"value":1666,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1686,"modifier":"EXACT"},"end":{"value":1707,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Myosin motor","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51456"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Actin-binding","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}]},{"type":"Region","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1516,"modifier":"EXACT"},"end":{"value":1593,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1753,"modifier":"EXACT"},"end":{"value":1777,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1866,"modifier":"EXACT"},"end":{"value":1917,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1518,"modifier":"EXACT"},"end":{"value":1528,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1529,"modifier":"EXACT"},"end":{"value":1546,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1572,"modifier":"EXACT"},"end":{"value":1592,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1761,"modifier":"EXACT"},"end":{"value":1777,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1874,"modifier":"EXACT"},"end":{"value":1884,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022676"}],"id":"KW-0328","category":"Molecular function","name":"Glycosyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023175"}],"id":"KW-0505","category":"Molecular function","name":"Motor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"id":"KW-0518","category":"Molecular function","name":"Myosin"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"24443419","citationType":"journal article","authors":["Zakrzewski A.C.","Weigert A.","Helm C.","Adamski M.","Adamska M.","Bleidorn C.","Raible F.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"24443419"},{"database":"DOI","id":"10.1093/gbe/evu011"}],"title":"Early divergence, broad distribution, and high diversity of animal chitin synthases.","publicationDate":"2014","journal":"Genome Biol. Evol.","firstPage":"316","lastPage":"325","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHX26700.1"}],"value":"LeasCS2","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHX26700.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KJ405452","properties":[{"key":"ProteinId","value":"AHX26700.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"GO","id":"GO:0016459","properties":[{"key":"GoTerm","value":"C:myosin complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004100","properties":[{"key":"GoTerm","value":"F:chitin synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0003774","properties":[{"key":"GoTerm","value":"F:cytoskeletal motor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006031","properties":[{"key":"GoTerm","value":"P:chitin biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd04190","properties":[{"key":"EntryName","value":"Chitin_synth_C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.550.10:FF:000139","properties":[{"key":"EntryName","value":"Chitin synthase 8"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.4820","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.530","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.850.10","properties":[{"key":"EntryName","value":"Kinesin motor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR004835","properties":[{"key":"EntryName","value":"Chitin_synth"}]},{"database":"InterPro","id":"IPR055120","properties":[{"key":"EntryName","value":"Chs-1/2_IV_N"}]},{"database":"InterPro","id":"IPR036961","properties":[{"key":"EntryName","value":"Kinesin_motor_dom_sf"}]},{"database":"InterPro","id":"IPR001609","properties":[{"key":"EntryName","value":"Myosin_head_motor_dom-like"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR22914","properties":[{"key":"EntryName","value":"CHITIN SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22914:SF42","properties":[{"key":"EntryName","value":"CHITIN SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03142","properties":[{"key":"EntryName","value":"Chitin_synth_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23000","properties":[{"key":"EntryName","value":"ChitinSynthase_IV_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00063","properties":[{"key":"EntryName","value":"Myosin_head"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50096","properties":[{"key":"EntryName","value":"IQ"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51456","properties":[{"key":"EntryName","value":"MYOSIN_MOTOR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAELPEGGDNMPDGENQNEEESGDDSYMTKPKNRNISSSPADLLSLKRGDKTLTDKSQNTVGQYFRNSLVDLMTKMNSSDPHFVRCLKPNVQKLPDEVEIDYVLDQLRSNGLIEIAKIRQQGYPVRIEFGEFIDKYKVLAFKPLTSVDPTGANCLLIAQKAQLEEFAIGESKIFLKYCHVDRLNACLAEIEGKVSRVQAVVRGVLARRKINEDVARKKMEQIALDALKQMHDEDLAKTGKPNIKPLDYKNILSPLKDGNFAAMNGDEKYIHVESIESEKKAYASKLAEDNRPRVRKKKRKRRNSVTSACTSETTSTSQMTLSTEDNNAQPVWDIFKTVSRKSETLYETSTNWFEVAAKSLKVFAYLFIFVCVLASAIASKGSLLLMTQSMGDTSQGWEYRDRWVYLLISTLCLPYLFTFFESLFKTLFGNKPSPSIGNVIWILFVETIHSFGLCLFVFRVLPCLDTVRSLLLMNAFCSVPAVFRLFATKRSEDPRRRMTTIILDFFAALMQISAYVIVMFSMRTNCLKTFTHSSANETDVKLMIENIGETTAAAQKIEEKSVWDQEYHLSDMSWELPVAMLMISTNWWENFIDKDFRLGFIEIPVKQYKDSLHRVRVKTYILASLWKVGLTFGFAFLLVPNLSMAHDAFSGIFKTTTVYYNTTGTTTMSPQSLSGTIRPEDRPPSTTDTPAIFRLKFPKEKYMVLQSFNCSEVSVMNVSMSVSYVNQTLCQEVYVDPWMHWYSYMPLLVQVVCSGLCYYFARLACKLCMQRFSFAVPLCLATPVSVGIVIGLCHLHPDKIVVLDDFLQWGCTGDGLKERWFIWHLGIGFGLWWVSQLWVTRYIWTPKAPRLAFTERLFLLPLYCGGLIEQSLLLNRRRNDKERILKELAFSDDVSLDSGSTDTMKKQAQQIVPKIYICATMWHETENEMVKLLKSVFRMDIDQSARRNAQDYFNVQDPDYYEFEAHIFIDDAMAFNDSDEWMPNMFVKQMVDVIERAACDIHESEVNLAHPCRIPTPYGGRLMWTLPGGNHLFAHIKDRNKVRHKKRWSQVMYMYYLLGYRLVAQQEESMQSGNGSSISLEKSDKWKLTNHHFTRGTLFKNVPEKVLILAENTYILALDGDVDFKPGAVQLLADRMKKSKKVGAACGRIHPIGSGPMIWYQNFEYAVGHWLQKAAEHMLGCVLCSPGCFSLFRGSALMDDNVMRTYATKSSEARHYLQYDQGEDRWLSTLMLQQGYRVEYCAASDAMTHAPERFVEFFNQRRRWIPSTLANIMDLLASYRSTVKINDNISYLYMAYQGALMLSTVLGPATVLLMMAGAYNAVMRISLWQSYLMSVGPAILFLILCFVTKGEIQLTIAAILSAVYSLLMMAVIVGTMVQIAEDTIVSPNAIFLMMLVFIFVVSACFHPQEFLCLIPGALYFLCIPSGYVLLIIYAMCNLHVVSWGTREMATVKLDPETEKKRQQQEQGGFMAWLGRNEDHEACCGIVGFFRRLCGNRHNDVNNEFLRQVMEKLDRVEQGVRSVSSGTSVHGRRRSSSRRSSSRRSRRSNIEDIEEEDDGNTRDDDSQTSTSSDEERSHHEEERDDLVNPRWLDDSGLGGGEVQYLPEKEIDFWEKFIQKYLHPIPPDRQHQAKIAEDLKSMRNNVAFAFFMMNAFWMIIIFMLQSVKDRVSISIPRYNGNDPLPIEPLGLIFLVFFAFILILQFCAMLRHRYGTLLHILASTELRCCGKRYDPRKHILEAVEYARVLQRLPGFDEEPESTDQETLNLGKSNVPQNNLRVNDRYNGNVPMFENGHLPDGSSSPIPTMFDNAAFCHSTPSMMEAVRRENSDPAPAVSRRQRHRHGGIMEKNNTLRRAFVRRYTKLMREHSADVASEAPTNSNFMNGETGSSSPPRRTRSLSRRRGENAQDLMSRFNKLNR","length":1917,"molWeight":219253,"crc64":"5B58B8168D7B0BC1","md5":"8F8819D7AE1E5BEFEFEECAA854334256"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2,"CAUTION":1},"countByFeatureType":{"Transmembrane":15,"Domain":1,"Region":6,"Compositional bias":7},"uniParcId":"UPI00045407D8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H6UNT6","uniProtkbId":"H6UNT6_9MOLL","entryAudit":{"firstPublicDate":"2012-04-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-04-18","entryVersion":38,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEZ54235.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019397"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Triosephosphate isomerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011940"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"5.3.1.1"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEZ54235.1"}],"value":"tpi"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18585"},{"database":"ChEBI","id":"CHEBI:57642"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"5.3.1.1","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate biosynthesis; gluconeogenesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004680"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007422"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"value":"Belongs to the triosephosphate isomerase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10127"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEZ54235.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEZ54235.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022432"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0312","category":"Biological process","name":"Gluconeogenesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023152"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0324","category":"Biological process","name":"Glycolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363013"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"21976685","citationType":"journal article","authors":["Vinther J.","Sperling E.A.","Briggs D.E.","Peterson K.J."],"citationCrossReferences":[{"database":"PubMed","id":"21976685"},{"database":"DOI","id":"10.1098/rspb.2011.1773"}],"title":"A molecular palaeobiological hypothesis for the origin of aplacophoran molluscs and their derivation from chiton-like ancestors.","publicationDate":"2012","journal":"Proc. R. Soc. B","firstPage":"1259","lastPage":"1268","volume":"279"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEZ54235.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN671514","properties":[{"key":"ProteinId","value":"AEZ54235.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H6UNT6","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00109","properties":[{"key":"RectionId","value":"UER00189"}]},{"database":"UniPathway","id":"UPA00138","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004807","properties":[{"key":"GoTerm","value":"F:triose-phosphate isomerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006094","properties":[{"key":"GoTerm","value":"P:gluconeogenesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0046166","properties":[{"key":"GoTerm","value":"P:glyceraldehyde-3-phosphate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019563","properties":[{"key":"GoTerm","value":"P:glycerol catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006096","properties":[{"key":"GoTerm","value":"P:glycolytic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd00311","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.70:FF:000016","properties":[{"key":"EntryName","value":"Triosephosphate isomerase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR035990","properties":[{"key":"EntryName","value":"TIM_sf"}]},{"database":"InterPro","id":"IPR000652","properties":[{"key":"EntryName","value":"Triosephosphate_isomerase"}]},{"database":"InterPro","id":"IPR020861","properties":[{"key":"EntryName","value":"Triosephosphate_isomerase_AS"}]},{"database":"NCBIfam","id":"TIGR00419","properties":[{"key":"EntryName","value":"tim"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21139","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21139:SF2","properties":[{"key":"EntryName","value":"TRIOSEPHOSPHATE ISOMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00121","properties":[{"key":"EntryName","value":"TIM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51351","properties":[{"key":"EntryName","value":"Triosephosphate isomerase (TIM)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00171","properties":[{"key":"EntryName","value":"TIM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51440","properties":[{"key":"EntryName","value":"TIM_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"NKQSIDVIIKFLEAGPLSENTEVVVGPPTLYLDYVRQKLDKKIGVSAQNCYKVAKGAFTGDISPAMIKDVGCEWVILGHSERRNVFGEPDELIGAKVAHALTEGLSVIACIGEKLEEREAGKTEEVVFRQMQAIVANVKDWSKVVIAYEPVWAIGTGKTATPEQAQDVHLALRTWMSKNVSADVGGAVRIIYGGSVTAGNCKDLGTRPDI","length":210,"molWeight":22696,"crc64":"8D47DF2593472F7B","md5":"AA7409223249B4770AC44BD3637FD827"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":2,"SUBUNIT":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00024E0AE2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A023PPX9","uniProtkbId":"A0A023PPX9_9MOLL","entryAudit":{"firstPublicDate":"2014-07-09","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2014-07-09","entryVersion":47,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHX26699.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHX26699.1"}],"value":"Chitin synthase"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004316"}],"value":"Cell projection","id":"SL-0280"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"value":"Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":905,"modifier":"EXACT"},"end":{"value":930,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":942,"modifier":"EXACT"},"end":{"value":964,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":976,"modifier":"EXACT"},"end":{"value":998,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1010,"modifier":"EXACT"},"end":{"value":1029,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1041,"modifier":"EXACT"},"end":{"value":1064,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1155,"modifier":"EXACT"},"end":{"value":1175,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1235,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1268,"modifier":"EXACT"},"end":{"value":1293,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1313,"modifier":"EXACT"},"end":{"value":1335,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1787,"modifier":"EXACT"},"end":{"value":1810,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1816,"modifier":"EXACT"},"end":{"value":1841,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1848,"modifier":"EXACT"},"end":{"value":1871,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":1883,"modifier":"EXACT"},"end":{"value":1900,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":2124,"modifier":"EXACT"},"end":{"value":2146,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":2167,"modifier":"EXACT"},"end":{"value":2191,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":753,"modifier":"EXACT"}},"description":"Myosin motor","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51456"}]},{"type":"Region","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":656,"modifier":"EXACT"}},"description":"Actin-binding","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}]},{"type":"Region","location":{"start":{"value":765,"modifier":"EXACT"},"end":{"value":805,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":853,"modifier":"EXACT"},"end":{"value":872,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2020,"modifier":"EXACT"},"end":{"value":2042,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2233,"modifier":"EXACT"},"end":{"value":2311,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2335,"modifier":"EXACT"},"end":{"value":2407,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":789,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2237,"modifier":"EXACT"},"end":{"value":2262,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2263,"modifier":"EXACT"},"end":{"value":2281,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2339,"modifier":"EXACT"},"end":{"value":2356,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2360,"modifier":"EXACT"},"end":{"value":2371,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2378,"modifier":"EXACT"},"end":{"value":2389,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023273"}],"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023175"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"id":"KW-0505","category":"Molecular function","name":"Motor protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"id":"KW-0518","category":"Molecular function","name":"Myosin"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00782"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"24443419","citationType":"journal article","authors":["Zakrzewski A.C.","Weigert A.","Helm C.","Adamski M.","Adamska M.","Bleidorn C.","Raible F.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"24443419"},{"database":"DOI","id":"10.1093/gbe/evu011"}],"title":"Early divergence, broad distribution, and high diversity of animal chitin synthases.","publicationDate":"2014","journal":"Genome Biol. Evol.","firstPage":"316","lastPage":"325","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHX26699.1"}],"value":"LeasCS1","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AHX26699.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KJ405451","properties":[{"key":"ProteinId","value":"AHX26699.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"GO","id":"GO:0016459","properties":[{"key":"GoTerm","value":"C:myosin complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004100","properties":[{"key":"GoTerm","value":"F:chitin synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0000146","properties":[{"key":"GoTerm","value":"F:microfilament motor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030832","properties":[{"key":"GoTerm","value":"P:regulation of actin filament length"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd04190","properties":[{"key":"EntryName","value":"Chitin_synth_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.820","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.4820","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.530","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.850.10","properties":[{"key":"EntryName","value":"Kinesin motor domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.720","properties":[{"key":"EntryName","value":"Myosin VI head, motor domain, U50 subdomain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036961","properties":[{"key":"EntryName","value":"Kinesin_motor_dom_sf"}]},{"database":"InterPro","id":"IPR052409","properties":[{"key":"EntryName","value":"Myosin-III_kinase_activity"}]},{"database":"InterPro","id":"IPR001609","properties":[{"key":"EntryName","value":"Myosin_head_motor_dom-like"}]},{"database":"InterPro","id":"IPR029044","properties":[{"key":"EntryName","value":"Nucleotide-diphossugar_trans"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR46256","properties":[{"key":"EntryName","value":"AGAP011099-PA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46256:SF3","properties":[{"key":"EntryName","value":"MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03142","properties":[{"key":"EntryName","value":"Chitin_synth_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00063","properties":[{"key":"EntryName","value":"Myosin_head"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00193","properties":[{"key":"EntryName","value":"MYOSINHEAVY"}]},{"database":"SMART","id":"SM00242","properties":[{"key":"EntryName","value":"MYSc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53448","properties":[{"key":"EntryName","value":"Nucleotide-diphospho-sugar transferases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51456","properties":[{"key":"EntryName","value":"MYOSIN_MOTOR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMQIYDTIDGDGDPKKIGLSVPGSADDLTYLDILDGDRILQELRVRYENDTYYTFIGDILLAVNPGNGVGLDVDDAELHVKYSNKAASPCRDPHVFWAAQHAHKNLKRKGRNQCILVSGESGAGKTECTKLLIKHLAHLSSPVTDTLHDSIVEVNPLLEAFGNASTVMNTNSSRFGKYVELYFKQEQGHLLGANIYDYLLEKSRVVLRGPGEKNFHVFYYLFAGMPEEELLYYYLEEPQKYRIFVDTDGNHSTHWTSEDVEIYREKFNELKTVMKRVGFADEEIGMIFTLLSSVIHLTNLTFLPDEETEGVQIDDEFTLRVVANLLYVDINELTTALISNIAYVSGERVECLKNQTQADDGRDALSKALYTRLFGWIVGQINNRIVPKDSAGLQESSISILDMSGFEHLRANSFEQICVNVANENLQQFFNDYIIDRDIREYESEGINLNDINFPNNQPLLDLFLKKPTGIFYIIDEESTFPKATDETLVQKLNSVCDVSENYVKSSFTDNSFTIKHYAGEVSYTTNGFLEKNRDSLSFNLIECMQNSTNEFVKALFLSSVSETGSISRTSSFVRVKGSPRTKRAEIARDNGKISLSKALARRIRRHSKSGTASHQNTGSRSTCTMGIYFRRSLADLLAKMSKTKPWFVRCIRANETCKKTDFDDRLVMRQLKCTGILEVTRIRKEGYAVRMSFRDFLDRYGELQFPTGAAVDPTPENCNCILSDVSDDGYVIGKTKIYMRKKNNKLLQATLRQKRHRRAELERLMMAQSSSDTDQRPIYSDHSRAESIDTTDASSTRSSNGFRGDILSVHSQSTQSMDKTGYGGSIISEQPYGSKDDLAKEFGIDYQANKNAEKNMTAPPPPPKPRVDPASNLSPRMWDRFRMIPRERVSSSERFEPLLKLFKIFWYMFLFVIVLGSAVVNKTTLLLMTTGLSVAGSAQNIFRTQLVVALIFPYACWFLLYTLKASFGNQVWPSLKLYCAVFFVEGLHSLGVSLIVFRILPRVDMVRGLMILTTVAIFPAFMKTLIKMKEFSTTGGVKRFSLVVLNAFAFLIQLGAIPVLMILRFLVTIPEKHIALEKAGRSNIVNRTESNILHRDASTTVLDFRSIAWEIPVALVCVSLAYWENFADSDLLVCGLKISMNKWKKNLHACREKVYMFVSLWKIIWTLTFAYLLLDNFFLTLFVYDDDRNVTTKTGDTKELFRGKRQADNATFVGTPDPDENSVHLTQEAIRHHFLAYGPMWALMVSTLLCSYFGMMACKLCMQLIGFAMPMLLATPATLAVILLQCMGPNWIPSHLNLIVWYCPEQSGSMLPFHYICLGLLWLSQMIIASHIWVPASGRMTKTERLFVLPMRCTALLEQSLLLRRRRDDNDLALKMTEEEEEELDENYKANDVVPRIYACATMWHETRNEMTQLLKSLFRMDQDHSARYLAQRFFKIKDPDFYEFEAHIFFDDAMELSDDDAMVPNQFVANLIDSMNDACSSVHERPMFMEAPIKTVTPYGGRLTWRLPGRTKLVVHLKDKTKIRHKKRWSQVMYMYYLLGYRIFAIKEYKQMKEGGEGKRFTEYDGSPIKLSATELRRRRRAAHYSRSAIFHQMDDDMEIQAENTFVLTLDGDVDFKPDAVRLLMDRVRKNKKVGAACGRIHPIGAGPLIWYQDFEYAIGHWLQKAAEHVFGCVLCAPGCFSLFRGSALMDDNVVRSYATRATEASQYIQYDQGEDRWLCTLLLQQGYRVEYCAASDALTHAPESFFEFFNQRRRWGPSTLANVIDLISDWKNTIRLNDNISRFYMLYQFLFMVSTILGPATILLMIIGSLNVVLNIAIGWAYVLGLAPPITYIIICLYMRTTIQLYAGAILSAMYAIVMTVAIVGSISNAVVGGPTSPNTIFLILLAAVFLISALMHPQETLSIVYGILYLICIPAGYLILTVYYLCNLNNVTWGTREMPVKKTPEQLEAEERAKEEKKKKSGLMVKLGLDVAIREMKDLLKQLHGYMTGANAKKTKTDVLLEELILEMKQKREGSTESTVIKSSEVMEEEEDEERGEHPLHEVVTTLPRSTITERFPREDPKRPGWLKYPKVGDGPCRPLKHLEDAFWRQLIGRYLHPIKEDKLHQEKVKQDLKNLRNNVVFGFFMVNAIWMVLSLELAIVYDRVQGLFIALPHVEEGKQNHLEPLGFVFLFLFGLLLVSQFLAMLIHRWGTLLHLLSITEVPLVGKKHGIQDAARDAIEKTKQLQRLRDIEFEPEPDPDYPTDEDMNEPYPDYDSEYESSLTSSPSDSVLSDIPPSYHSDEDYYQQVYDKKDKKKRKRRSVFNDRGFSTGHTLQQAFIRRFRRMQLEEQDRQASVRSGSHTSRPSLFTAFNISREATEAGDSRPETDAEAGPSRASSAMSLSAMGTTPAPHAYMSHEFPVSS","length":2407,"molWeight":274335,"crc64":"CF5F6C9A853D195F","md5":"8720E381AB9B51CE5DF0B7A0C98D6DD6"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":15,"Domain":1,"Region":6,"Compositional bias":7,"Binding site":1},"uniParcId":"UPI00045406BD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0DN34","uniProtkbId":"A0A0Y0DN34_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-04-13","entryVersion":33,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26731.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369122"}],"value":"Guanine nucleotide-binding protein subunit alpha"}}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369122"}],"value":"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011356"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369122"}],"value":"G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007976"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369122"}],"value":"Belongs to the G-alpha family. G(q) subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"G1 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Region","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"G2 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Region","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"G3 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Region","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"G4 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Region","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"G5 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Binding site","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240"}},{"type":"Binding site","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240"}},{"type":"Binding site","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-2"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26731.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193721","properties":[{"key":"ProteinId","value":"AMB26731.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0DN34","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005834","properties":[{"key":"GoTerm","value":"C:heterotrimeric G-protein complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0001664","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0031683","properties":[{"key":"GoTerm","value":"F:G-protein beta/gamma-subunit complex binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007188","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00066","properties":[{"key":"EntryName","value":"G-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.400.10:FF:000002","properties":[{"key":"EntryName","value":"guanine nucleotide-binding protein G(Q) subunit alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000692","properties":[{"key":"EntryName","value":"Guanine nucleotide-binding protein subunit alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.400.10","properties":[{"key":"EntryName","value":"GI Alpha 1, domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000654","properties":[{"key":"EntryName","value":"Gprotein_alpha_Q"}]},{"database":"InterPro","id":"IPR001019","properties":[{"key":"EntryName","value":"Gprotein_alpha_su"}]},{"database":"InterPro","id":"IPR011025","properties":[{"key":"EntryName","value":"GproteinA_insert"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR10218","properties":[{"key":"EntryName","value":"GTP-BINDING PROTEIN ALPHA SUBUNIT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10218:SF329","properties":[{"key":"EntryName","value":"GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00503","properties":[{"key":"EntryName","value":"G-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00318","properties":[{"key":"EntryName","value":"GPROTEINA"}]},{"database":"PRINTS","id":"PR00442","properties":[{"key":"EntryName","value":"GPROTEINAQ"}]},{"database":"SMART","id":"SM00275","properties":[{"key":"EntryName","value":"G_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47895","properties":[{"key":"EntryName","value":"Transducin (alpha subunit), insertion domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51882","properties":[{"key":"EntryName","value":"G_ALPHA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MACCLSEEAKEQKRINQEIEKQLRKDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGTGYSDEDKRSFIKLVYQNIFMAMHAMIRAMDTLKIEYKDPNNKENGNGIKQVDYETVTTFESNNVDAIKCLWADVGIQECYDRRREYQLTDSAKYYLDSVDRISNNNYLPTLQDILRVRVPTTGIIEYPFDLDSIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMHSHLVDYFPEFDGTKKDAQAAREFILRMFVDLNPDPDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV","length":353,"molWeight":41414,"crc64":"27093A4283B4F835","md5":"6CEC16ED4CEC02090D5A2892A57F0E07"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Region":5,"Binding site":10},"uniParcId":"UPI0007630FAA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0DYJ8","uniProtkbId":"A0A0Y0DYJ8_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2025-10-08","lastSequenceUpdateDate":"2016-04-13","entryVersion":30,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26730.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26730.1"}],"value":"Forkhead Q2 B"}}],"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00089"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Fork-head","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50039"}]},{"type":"DNA binding","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Fork-head","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00089"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26730.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26730.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00089"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00089"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26730.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193720","properties":[{"key":"ProteinId","value":"AMB26730.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0DYJ8","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0009653","properties":[{"key":"GoTerm","value":"P:anatomical structure morphogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd20035","properties":[{"key":"EntryName","value":"FH_FOXQ2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000135","properties":[{"key":"EntryName","value":"forkhead box protein G1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR047519","properties":[{"key":"EntryName","value":"FH_FOXQ2-like"}]},{"database":"InterPro","id":"IPR001766","properties":[{"key":"EntryName","value":"Fork_head_dom"}]},{"database":"InterPro","id":"IPR050211","properties":[{"key":"EntryName","value":"FOX_domain-containing"}]},{"database":"InterPro","id":"IPR018122","properties":[{"key":"EntryName","value":"TF_fork_head_CS_1"}]},{"database":"InterPro","id":"IPR030456","properties":[{"key":"EntryName","value":"TF_fork_head_CS_2"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR11829:SF142","properties":[{"key":"EntryName","value":"FORK-HEAD DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11829","properties":[{"key":"EntryName","value":"FORKHEAD BOX PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00250","properties":[{"key":"EntryName","value":"Forkhead"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00053","properties":[{"key":"EntryName","value":"FORKHEAD"}]},{"database":"SMART","id":"SM00339","properties":[{"key":"EntryName","value":"FH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00657","properties":[{"key":"EntryName","value":"FORK_HEAD_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00658","properties":[{"key":"EntryName","value":"FORK_HEAD_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50039","properties":[{"key":"EntryName","value":"FORK_HEAD_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DELRFPSKPVDHVAEEFYRQNTMSAPGLPRSDISRRPSTRNGIDNMSSSGSENDSVSSASDNDSISLDSTESIAQVLLSLDRRSRVFPSTNNNTARPPQSPSSSDGDQKPPHSYIALISMAILSSPGEKALLGDIYQYIMDNYPYYNNTERAWRNSIRHNLSLNECFIKNGRADNGKGNFWSIHPACVEDFAKGDYRRRQARRRARKTTKETNLIAAQQGYGYNIGYVPMQSSTIGHHSYHSLTSQMFTLGPQVQSTVTGSPQEYHPYYGVTPEMMTLDSQLP","length":283,"molWeight":31670,"crc64":"A0A8E4A067FDD1E9","md5":"B01963CBFE46E1913B0872C89A53573B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"DNA binding":1,"Region":2,"Compositional bias":3,"Non-terminal residue":2},"uniParcId":"UPI0007632F14"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0GMM1","uniProtkbId":"A0A0Y0GMM1_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-04-13","entryVersion":32,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26752.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}],"value":"Eyes absent homolog"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}],"value":"3.1.3.48"}]},"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10684"},{"database":"Rhea","id":"RHEA-COMP:10136"},{"database":"Rhea","id":"RHEA-COMP:20101"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:46858"},{"database":"ChEBI","id":"CHEBI:61978"}],"ecNumber":"3.1.3.48","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051722"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}],"value":"Binds 1 Mg(2+) ion per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010501"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}],"value":"Belongs to the HAD-like hydrolase superfamily. EYA family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-1"}]},{"type":"Active site","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-1"}]},{"type":"Binding site","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26752.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26752.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR628472-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022912"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}],"id":"KW-0904","category":"Molecular function","name":"Protein phosphatase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362036"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26752.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193742","properties":[{"key":"ProteinId","value":"AMB26752.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0GMM1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004725","properties":[{"key":"GoTerm","value":"F:protein tyrosine phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:2001240","properties":[{"key":"GoTerm","value":"P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0045739","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA repair"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.50.12350","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR028472","properties":[{"key":"EntryName","value":"EYA"}]},{"database":"InterPro","id":"IPR006545","properties":[{"key":"EntryName","value":"EYA_dom"}]},{"database":"InterPro","id":"IPR038102","properties":[{"key":"EntryName","value":"EYA_dom_sf"}]},{"database":"NCBIfam","id":"TIGR01658","properties":[{"key":"EntryName","value":"EYA-cons_domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10190:SF16","properties":[{"key":"EntryName","value":"DEVELOPMENTAL PROTEIN EYES ABSENT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10190","properties":[{"key":"EntryName","value":"EYES ABSENT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GGFSSYPYSPSTTAYPSSYYSPYMTQTTGGVGSVATTVPSTQTYQLRDVPPTVTAVDTSHSANHLIHMHGRAVQSLQHVLQANHRLPPTDSNLHISADNQFPSIPSSPSPTAIKTETNGNAKRRDTGRGRRQTNPSPGPESDLERVFVWDLDETIIIFHSLLTGSYAQRYGKDPPASVSLGLRMEEMIFNLADSHLFFNDLEECDQVHIDDVSSNDNGQDLSTYNFATDGFHAAANNANLCLATGVRGGVDWMRKLAFRYRRIKEIYNSYRNNVGGLLGPQKREQWLQLRQEIESMTDNWLTLALKSLSIINSRSNCVNVLVTTTQL","length":327,"molWeight":36284,"crc64":"A27D5F23078FBA4B","md5":"B3F70E95670D128457E375B40AF581E9"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1,"Active site":2,"Binding site":2,"Non-terminal residue":2},"uniParcId":"UPI000763161E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0H5B0","uniProtkbId":"A0A0Y0H5B0_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2025-10-08","lastSequenceUpdateDate":"2016-04-13","entryVersion":32,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26729.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26729.1"}],"value":"Forkhead Q2 A"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00089"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Fork-head","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50039"}]},{"type":"DNA binding","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Fork-head","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00089"}]},{"type":"Region","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00089"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00089"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26729.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193719","properties":[{"key":"ProteinId","value":"AMB26729.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0H5B0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0009653","properties":[{"key":"GoTerm","value":"P:anatomical structure morphogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd20035","properties":[{"key":"EntryName","value":"FH_FOXQ2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000352","properties":[{"key":"EntryName","value":"Forkhead box Q2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR047519","properties":[{"key":"EntryName","value":"FH_FOXQ2-like"}]},{"database":"InterPro","id":"IPR001766","properties":[{"key":"EntryName","value":"Fork_head_dom"}]},{"database":"InterPro","id":"IPR050211","properties":[{"key":"EntryName","value":"FOX_domain-containing"}]},{"database":"InterPro","id":"IPR030456","properties":[{"key":"EntryName","value":"TF_fork_head_CS_2"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR11829:SF343","properties":[{"key":"EntryName","value":"FORK-HEAD DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11829","properties":[{"key":"EntryName","value":"FORKHEAD BOX PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00250","properties":[{"key":"EntryName","value":"Forkhead"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00053","properties":[{"key":"EntryName","value":"FORKHEAD"}]},{"database":"SMART","id":"SM00339","properties":[{"key":"EntryName","value":"FH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00658","properties":[{"key":"EntryName","value":"FORK_HEAD_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50039","properties":[{"key":"EntryName","value":"FORK_HEAD_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MCSNNATNVNMLPYGLRVPNPAPLLPLLGGMGQTPLDFHRAQVYDYSGRLNLQFALRGYPTMSPYHPMGNSADPFRHLYLYAKHDPRANFMHEEPKPSQSYIGLIAMAILSVPDKKMVLSDIYQYILDHYPYFRTRGPGWRNSIRHNLSLNDCFIKSGRSANGKGHYWAIHPANLEDFKKGDFRRRRAQRRVRKYLGLSVPDDEDSPSPSPTSTHQETWMEEKDGDDTTAQATAEGKPADDNAVILPNLSMTVSSITDHNCNRGPGAILENDNMRGVVQKTTGIKRRLFDMESLLAPDTDSPRAFKTFVATDLSIRREVREVREDSDTEIVVTDDRCSPSGDVTRQISVSSDSERTTLDQSGSSKSEEENEVSSTDNEQGTNGLNLNIKSWRDNKQNQVNSDAGVPRVIKIHPSSPAVVTNGLGGLPFPPHHAIPTPIQLAQQGLTWQDRPSAFQRMSNGNLSRTLSPVSYSPLMVQGRPAFPICLSTSDPVTSAQKWQETLSRIMARSYDKPVKTDS","length":518,"molWeight":57756,"crc64":"5E341C64C9763A53","md5":"0C9B3E179C913F91D471AAB38E57C528"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"DNA binding":1,"Region":2,"Compositional bias":2},"uniParcId":"UPI000762FBE2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0H9H7","uniProtkbId":"A0A0Y0H9H7_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2025-06-18","lastSequenceUpdateDate":"2016-04-13","entryVersion":35,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26742.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26742.1"}],"value":"Sine oculis homeobox 3/6 A"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000682"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008161"}],"value":"Belongs to the SIX/Sine oculis homeobox family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50071"}]},{"type":"DNA binding","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023155"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0371","category":"Domain","name":"Homeobox"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26742.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193732","properties":[{"key":"ProteinId","value":"AMB26742.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0H9H7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000046","properties":[{"key":"EntryName","value":"SIX homeobox 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR031701","properties":[{"key":"EntryName","value":"SIX1_SD"}]},{"database":"PANTHER","id":"PTHR10390","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN SIX"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10390:SF33","properties":[{"key":"EntryName","value":"PROTEIN OPTIX"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00046","properties":[{"key":"EntryName","value":"Homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16878","properties":[{"key":"EntryName","value":"SIX1_SD"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFHLPMLHFTPGQVAQVCEILEESGDIERLGRFLWSLPVNPSARDSLNQHESILRARSMVAFHTGNFRDLYQILETHKFTKESHAKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRNLLREWYLQDPYPNPSKKRELAQGTGLTPTQVGNWFKNRRQRDRAAAAKNRLHNRHRQNGRLESSSSASSTPEASASGDHKDGLDSPRSSDSPISDSFLDDDFDDDDDLDVDSPGTPPRSSPSPPPMLGNTTLTSSRPT","length":279,"molWeight":31810,"crc64":"FDEB4DA39C3909F9","md5":"A495F6E6D3B3F32E328F74A0C0E51D41"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"DNA binding":1,"Region":1,"Compositional bias":6},"uniParcId":"UPI0007632137"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0HPJ9","uniProtkbId":"A0A0Y0HPJ9_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2016-04-13","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26732.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26732.1"}],"value":"Iroquois 4/6"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008446"}],"value":"Belongs to the TALE/IRO homeobox family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50071"}]},{"type":"DNA binding","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023155"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0371","category":"Domain","name":"Homeobox"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26732.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193722","properties":[{"key":"ProteinId","value":"AMB26732.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0HPJ9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0048468","properties":[{"key":"GoTerm","value":"P:cell development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030182","properties":[{"key":"GoTerm","value":"P:neuron differentiation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000003","properties":[{"key":"EntryName","value":"Iroquois-class homeobox protein IRX"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR017970","properties":[{"key":"EntryName","value":"Homeobox_CS"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR008422","properties":[{"key":"EntryName","value":"KN_HD"}]},{"database":"PANTHER","id":"PTHR11211","properties":[{"key":"EntryName","value":"IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11211:SF40","properties":[{"key":"EntryName","value":"MIRROR, ISOFORM C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05920","properties":[{"key":"EntryName","value":"Homeobox_KN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00027","properties":[{"key":"EntryName","value":"HOMEOBOX_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTAYTQFATYPYPAGTTGALTPAQLSSSSSSSSRSCCENGRPIMTDPHTGQTICSCQYGPGLIPYPRVPGLPDGVFSSSAYTQGYLQIGADASAFYSPLANSPYEVKENAEGWRSLQQSAAGACFPYEASMAMYPYGPGYGGLDLNGARRKNATRETTNTLKAWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNRSDDDGDDLDDMGEDDRDDDEDGREKSGDSDSADPSDATTNNPISTRKEQGQEDAVDSSDCHINVDDLPVSPSPLLRPTRETGSDGSERHRLSPVSPVLVEEDKDSSIGSPCPSLSPPVGELPTGGALSKDSHRSNKTSHRESPEVSRPKIWSVSQFLPTNSENHNSREPAVTSSLSSSASHLYHTSPSSSHRAMTSQGQCHPFLPSVSSHAYAGNYGSAISYVTHPLPMTMSSASLAFPYTISSVKSSLPNGSTTLPRQEALLAHSSSVLRQQADFLSHSRARDLSSRANGALDKERDTASMIL","length":521,"molWeight":56324,"crc64":"699EA8E4C59B9C6D","md5":"8AD78948BA67E0134003E3BD8FC7A6FF"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"DNA binding":1,"Region":1,"Compositional bias":5},"uniParcId":"UPI00076313BA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0HPL2","uniProtkbId":"A0A0Y0HPL2_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-04-13","entryVersion":26,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26747.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039304"}],"value":"Tyrosinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011906"}],"value":"1.14.18.1"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00042251"}],"value":"Monophenol monooxygenase"}}]},"comments":[{"commentType":"COFACTOR","cofactors":[{"name":"Cu(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001973"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29036"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046288"}],"value":"Endomembrane system","id":"SL-0147"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046288"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"Tyrosinase","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5007072917"},{"type":"Transmembrane","location":{"start":{"value":525,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"Tyrosinase copper-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00497"}]},{"type":"Domain","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Tyrosinase copper-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS00498"}]},{"type":"Region","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":582,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":595,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023033"}],"id":"KW-0503","category":"Molecular function","name":"Monooxygenase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26747.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193737","properties":[{"key":"ProteinId","value":"AMB26747.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0HPL2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004503","properties":[{"key":"GoTerm","value":"F:tyrosinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042438","properties":[{"key":"GoTerm","value":"P:melanin biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0043473","properties":[{"key":"GoTerm","value":"P:pigmentation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.10.1280.10","properties":[{"key":"EntryName","value":"Di-copper center containing domain from catechol oxidase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008922","properties":[{"key":"EntryName","value":"Di-copper_centre_dom_sf"}]},{"database":"InterPro","id":"IPR050316","properties":[{"key":"EntryName","value":"Tyrosinase-like"}]},{"database":"InterPro","id":"IPR002227","properties":[{"key":"EntryName","value":"Tyrosinase_Cu-bd"}]},{"database":"PANTHER","id":"PTHR11474:SF124","properties":[{"key":"EntryName","value":"TYROSINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11474","properties":[{"key":"EntryName","value":"TYROSINASE FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00264","properties":[{"key":"EntryName","value":"Tyrosinase"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00092","properties":[{"key":"EntryName","value":"TYROSINASE"}]},{"database":"SUPFAM","id":"SSF48056","properties":[{"key":"EntryName","value":"Di-copper centre-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00497","properties":[{"key":"EntryName","value":"TYROSINASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00498","properties":[{"key":"EntryName","value":"TYROSINASE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MYVARSRLNSLTWPESGICFICVLLSIWKGAVGQFPIACVGNATLTNSTCCPIPPGFDSPCGAPFRGKCTEIRDNNEDYSGASSQTANDDRFHWPRKFFIYGCECSGNFAGYMCHECSYGFTGDNCTERIVRIRKNLNKVTPSEKRYILSIMEKARRTQSDYALIDVSKGADPVENVQFVTASVYDYLAYVHYYASRKTIFRTSPDPENTKKPFRCDRPGFSGLDFAHRGSNFPIWHRYYMMVWEKEMQKLSGDIYFTFPYWNWTDAGNTCEVCTNDFLGASNENGSIQQSALTAGWYALCMRESGKCEDCDPKKRYTLIRTPSKVKSASYLPTSETVNFAMSQPIWDFDDYSTSTPNASFRSCLEGYVGIPENATYRLHNQVHMFFGGALNSATSASWDPMFYFHHSFMDKILEMWLRRTGAQPTQLPMTGAPPGHHRNSYLMAYFPVRESSLFFRPSVDLGYTYDDMVENAEVEGMPSSTEEPTRPTDAPSPIIGTGRHIEAPIDDVTSCRDRVAMESQSNDILIRVIVVETAILCVLLLIVISACVHAFTGKKKRRYARVQDDDDDDDEVNEKLLGMEKQQQPVLLSLDAGSETESDDLQT","length":604,"molWeight":68222,"crc64":"A3112A242B6AA78F","md5":"317F7359DFD2365705A7C009B5AB579D"},"extraAttributes":{"countByCommentType":{"COFACTOR":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":1,"Domain":2,"Region":2,"Compositional bias":1},"uniParcId":"UPI0007632A83"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0HYG9","uniProtkbId":"A0A0Y0HYG9_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-04-13","entryVersion":26,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26734.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00068012"}],"value":"Krueppel-like factor 2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080631"}],"value":"Lung krueppel-like factor"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055776"}],"value":"Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064490"}],"value":"Interacts with WWP1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006991"}],"value":"Belongs to the krueppel C2H2-type zinc-finger protein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":352,"modifier":"EXACT"},"end":{"value":381,"modifier":"EXACT"}},"description":"C2H2-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50157"}]},{"type":"Domain","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"C2H2-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50157"}]},{"type":"Domain","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"C2H2-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50157"}]},{"type":"Region","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023159"}],"id":"KW-0010","category":"Molecular function","name":"Activator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022843"}],"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00042"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26734.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193724","properties":[{"key":"ProteinId","value":"AMB26734.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0HYG9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"3.30.160.60:FF:000018","properties":[{"key":"EntryName","value":"Krueppel-like factor 15"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.60:FF:000237","properties":[{"key":"EntryName","value":"Krueppel-like factor 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.60:FF:001156","properties":[{"key":"EntryName","value":"Zinc finger protein 407"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR013087","properties":[{"key":"EntryName","value":"Zf-C2H2_type"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"PANTHER","id":"PTHR23235:SF158","properties":[{"key":"EntryName","value":"C2H2-TYPE DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23235","properties":[{"key":"EntryName","value":"KRUEPPEL-LIKE TRANSCRIPTION FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00096","properties":[{"key":"EntryName","value":"zf-C2H2"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00355","properties":[{"key":"EntryName","value":"ZnF_C2H2"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00028","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50157","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_2"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MTQAMDPMLTSNAFSSSASLMSKYEDTVDLQNTWQDVENLLYPDNNPYESSMVQMISQAEPSILSTASGSYITSLRNITTASPIGSITTTTNTSQLSIPHIGSMPSPQSDTDQQPRECYDDLLDLDFILTNTVDNNNMYPEDAGLLKVKLEPGTTHEPLPDFHSTFLDIPDIKLDNNMNEMMVDHHVPQVQQPQINVKVPDYKTVIPKQEFPPVPNTCASYNAMMTIIPNAHHQMHFIPGHISPPASPELHDEKALMSRDYRHQMGMMHPHQTHHHIQQTHHQQHIMMPHHLMTKMAHHSQNHMIQVPHQMITPPSSPQLVDLLLPQAAVDTAPQPKKRGRRTWGRKRQTSHTCTHPGCQKTYTKSSHLKAHLRTHTGEKPYHCNWKGCGWKFARSDELTRHYRKHTGDRPFQCHLCERAFSRSDHLSLHMKRHI","length":435,"molWeight":49698,"crc64":"9339A35C82BEE0AB","md5":"F5C496DC6AF7C846DAE2BEDB594AE24C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":3,"Region":2,"Compositional bias":1},"uniParcId":"UPI000762EBD3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0HYM7","uniProtkbId":"A0A0Y0HYM7_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-04-13","entryVersion":36,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26749.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00068167"}],"value":"Homeobox protein ceh-24"}}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00057950"}],"value":"Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000682"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50071"}]},{"type":"DNA binding","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023155"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0371","category":"Domain","name":"Homeobox"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26749.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193739","properties":[{"key":"ProteinId","value":"AMB26749.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0HYM7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000296","properties":[{"key":"EntryName","value":"Scarecrow, isoform A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR020479","properties":[{"key":"EntryName","value":"HD_metazoa"}]},{"database":"InterPro","id":"IPR017970","properties":[{"key":"EntryName","value":"Homeobox_CS"}]},{"database":"InterPro","id":"IPR050394","properties":[{"key":"EntryName","value":"Homeobox_NK-like"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"PANTHER","id":"PTHR24340","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN NKX"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24340:SF41","properties":[{"key":"EntryName","value":"MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00046","properties":[{"key":"EntryName","value":"Homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00024","properties":[{"key":"EntryName","value":"HOMEOBOX"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00027","properties":[{"key":"EntryName","value":"HOMEOBOX_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSLSPKHTTPFSVTDILSPIEETYKKTTIEAAIPPLATAYRSPQHHPQMGSMSSMSVPVTNPYHNYVPPLSHHTPSFPSQYCNGSELSHYGDPVRHSATSWYGPNTDPRFASYAAVSRLMGPSSCAMNPMSSGMNHMSMSLSGMDQAKMHGMQFPLTQRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMINLTPTQVKIWFQNHRYKCKRQQKDKDKMDGSHSSSGSSSQQQSSQQSQQQSQQQQSQSQQNNSLQPSPRRVAVPVLVKDGKPCTGAGGSEGQAGGAPPAHHQSSSQGQHNSLGHHQQTQVSQAPSHLGSSARSIHQVNSLNAGVISTHATNSHSQNTLNNHGLSAASLGYTAVSVNGSSMTSSPYLLNGRTW","length":388,"molWeight":42457,"crc64":"7376AE67E95ACC4D","md5":"A8DB922B946C7E5AAFAB65C5C69E0715"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"DNA binding":1,"Region":1,"Compositional bias":5},"uniParcId":"UPI0007632286"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0I0B8","uniProtkbId":"A0A0Y0I0B8_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2025-06-18","lastSequenceUpdateDate":"2016-04-13","entryVersion":36,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26743.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26743.1"}],"value":"Sine oculis homeobox 3/6 B"}}],"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000682"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008161"}],"value":"Belongs to the SIX/Sine oculis homeobox family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5007072924"},{"type":"Domain","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50071"}]},{"type":"DNA binding","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26743.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023155"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0371","category":"Domain","name":"Homeobox"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26743.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193733","properties":[{"key":"ProteinId","value":"AMB26743.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0I0B8","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0001654","properties":[{"key":"GoTerm","value":"P:eye development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000046","properties":[{"key":"EntryName","value":"SIX homeobox 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR031701","properties":[{"key":"EntryName","value":"SIX1_SD"}]},{"database":"PANTHER","id":"PTHR10390","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN SIX"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10390:SF12","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN SIX6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00046","properties":[{"key":"EntryName","value":"Homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16878","properties":[{"key":"EntryName","value":"SIX1_SD"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GWKPRGDARHASKRTFSFSPSALFLFAMFHLPMLHFTAGQVAQVCETLEESGDIERLGRFLWSLPVNPAALDALNQHEPVLKARAAVAFHSGNFRDLYHILENHKFGKDAHARLQAMWLESHYLEAERLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKSHCFKERTRNLLREFYLQDPYPNPAKKRELAQVTGLTPTQVGNWFKNRRQRDRAAAAKNRLHQKYQTQLRSTNKMGGDTSDEDICQPFLTNRGSPETTDVRNGCCRSEASSPISVKDEDCRNEHQTMKRELSNYEKEDFIVVDSPCSDV","length":307,"molWeight":35382,"crc64":"9481916ACA176C50","md5":"36F17527871726B5AA9A05AC89BD2F7F"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":1,"DNA binding":1,"Region":1,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI0007631C35"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0I158","uniProtkbId":"A0A0Y0I158_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2016-04-13","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26733.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26733.1"}],"value":"Iroquois 2/5"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008446"}],"value":"Belongs to the TALE/IRO homeobox family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50071"}]},{"type":"DNA binding","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023155"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0371","category":"Domain","name":"Homeobox"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26733.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193723","properties":[{"key":"ProteinId","value":"AMB26733.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0I158","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0048468","properties":[{"key":"GoTerm","value":"P:cell development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030182","properties":[{"key":"GoTerm","value":"P:neuron differentiation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000003","properties":[{"key":"EntryName","value":"Iroquois-class homeobox protein IRX"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR017970","properties":[{"key":"EntryName","value":"Homeobox_CS"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR008422","properties":[{"key":"EntryName","value":"KN_HD"}]},{"database":"PANTHER","id":"PTHR11211","properties":[{"key":"EntryName","value":"IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11211:SF15","properties":[{"key":"EntryName","value":"IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05920","properties":[{"key":"EntryName","value":"Homeobox_KN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00027","properties":[{"key":"EntryName","value":"HOMEOBOX_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSSYMEAGRQLPMHTLHPSDISRVYGRSPERQVHQRLPRLRIPQYPPQADMFSPCPPGFHAGISMHPHPHIEKESAYHPGVQPISPVGAEAMYNCVDPKLWTDPMINPLMLPPVFDTYYNGLDFHAPGYRKNVTKETTGPLKAWLQDHRKNPYPTKAEKIMLAIITKMTLTQVSTWFANARRRLKKETTGSPRSEDGDQKDASDEEDEKSDDPHSRNGSDDEYEEISVDDTDDECPSFISNHSPILPTSSYSTVNDRLLPSTETARSPDHRTAQGMPKMPPSSENTTTNCENGSVSASSVLSCSSKRQSDCDKSSSSETVPMDLSNSRTQAAQQHLQLRNPNLNHSQNDSGAKAKIWSISNILNLDSHSRDHQHS","length":375,"molWeight":41940,"crc64":"836354F5ACB1F7AF","md5":"EC5D6A514ED164481C49D35AE5E8DEE2"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"DNA binding":1,"Region":2,"Compositional bias":6},"uniParcId":"UPI000763121C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0Y0I1B1","uniProtkbId":"A0A0Y0I1B1_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-04-13","entryVersion":32,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26748.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26748.1"}],"value":"Frizzled5/8"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096288"}],"value":"Belongs to the G protein-coupled receptor Fz/Smo family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":337,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":571,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"FZ","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50038"}]},{"type":"Domain","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":578,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 2 profile 2","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50261"}]},{"type":"Region","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00090"}]},{"type":"Disulfide bond","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00090"}]},{"type":"Disulfide bond","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00090"}]},{"type":"Disulfide bond","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00090"}]},{"type":"Disulfide bond","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00090"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00090"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022687"}],"id":"KW-0879","category":"Biological process","name":"Wnt signaling pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26748.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193738","properties":[{"key":"ProteinId","value":"AMB26748.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A0Y0I1B1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0042813","properties":[{"key":"GoTerm","value":"F:Wnt receptor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0017147","properties":[{"key":"GoTerm","value":"F:Wnt-protein binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0060070","properties":[{"key":"GoTerm","value":"P:canonical Wnt signaling pathway"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0035567","properties":[{"key":"GoTerm","value":"P:non-canonical Wnt signaling pathway"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd15035","properties":[{"key":"EntryName","value":"7tmF_FZD5_FZD8-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd07456","properties":[{"key":"EntryName","value":"CRD_FZ5_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000262","properties":[{"key":"EntryName","value":"Frizzled 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.2000.10:FF:000004","properties":[{"key":"EntryName","value":"Frizzled class receptor 8a"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.2000.10","properties":[{"key":"EntryName","value":"Frizzled cysteine-rich domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR015526","properties":[{"key":"EntryName","value":"Frizzled/SFRP"}]},{"database":"InterPro","id":"IPR000539","properties":[{"key":"EntryName","value":"Frizzled/Smoothened_7TM"}]},{"database":"InterPro","id":"IPR020067","properties":[{"key":"EntryName","value":"Frizzled_dom"}]},{"database":"InterPro","id":"IPR036790","properties":[{"key":"EntryName","value":"Frizzled_dom_sf"}]},{"database":"InterPro","id":"IPR017981","properties":[{"key":"EntryName","value":"GPCR_2-like_7TM"}]},{"database":"PANTHER","id":"PTHR11309","properties":[{"key":"EntryName","value":"FRIZZLED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11309:SF126","properties":[{"key":"EntryName","value":"FRIZZLED-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01534","properties":[{"key":"EntryName","value":"Frizzled"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01392","properties":[{"key":"EntryName","value":"Fz"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00489","properties":[{"key":"EntryName","value":"FRIZZLED"}]},{"database":"SMART","id":"SM00063","properties":[{"key":"EntryName","value":"FRI"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01330","properties":[{"key":"EntryName","value":"Frizzled"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF63501","properties":[{"key":"EntryName","value":"Frizzled cysteine-rich domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50038","properties":[{"key":"EntryName","value":"FZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50261","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F2_4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSIAIVVGNRAMALHSQHRRMPGVAVSILAVYLLCISVGSGDQLRQCQEITIPMCKNIGYNLTYMPNQFNHETQEEAGLEVHQFWPLVEIHCSSDLKFFLCSMYAPICMTNYQKPLPACRTVCERAKAGCAPLMRQYGFAWPERMDCDNLPEYGTKGQLCMDANTTEKSTPPPKTKYPPIIPKPPPAGTGQHPTKKIYYPNNPPVPHNPDSPNSGGKGPIWTLPGDMSGFVPNCSCGCSKPLVSISKSSGRYSKISTGNVTNCAMNCDSPYFKGDEEKTFAVFWIGLWSVLCCISTLMTMLTFLIDMQRFKYPERPIIFLSGCYFMVSVGYIIRLVMGKESIACEKVMGENIIRYETTGPAVCTIVFLLIYFFGMASSIWWVILSFTWFLAAGLKWGQEAIARHSQYFHLTAWLIPSVKSIGVLAASSVDGDPIAGICYVGNQNIANLRGFVLAPLFVYLIIGTSFLLAGFVSLFRIRNVIKQQGRAKTDKLERLMIRIGVFSVLYTVPATIVISCYFYEQHMRLKWEKTVTCSCGSCPCSKDAAAPDFSVFMLKYFMCLVVGITSGFWIWTGKTLESWKKFYRKLCHRGEYSHPGRNKYTNQGYQAAKQQPLSHV","length":616,"molWeight":68975,"crc64":"AE58B01F30C8C180","md5":"84199835C2AC15057262D25A76697CA7"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":6,"Domain":2,"Region":1,"Compositional bias":1,"Disulfide bond":5},"uniParcId":"UPI000762E55F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A110AID8","uniProtkbId":"A0A110AID8_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-04-13","entryVersion":32,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26740.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26740.1"}],"value":"Prospero"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01162"}],"value":"The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01162"}],"value":"Belongs to the Prospero homeodomain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":770,"modifier":"EXACT"},"end":{"value":928,"modifier":"EXACT"}},"description":"Prospero","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51818"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":503,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":715,"modifier":"EXACT"},"end":{"value":761,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":770,"modifier":"EXACT"},"end":{"value":928,"modifier":"EXACT"}},"description":"Homeo-Prospero","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01162"}]},{"type":"Compositional bias","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":503,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":717,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01162"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023155"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01162"}],"id":"KW-0371","category":"Domain","name":"Homeobox"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01162"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01162"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26740.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193730","properties":[{"key":"ProteinId","value":"AMB26740.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A110AID8","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001227","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription repressor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0048468","properties":[{"key":"GoTerm","value":"P:cell development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0010001","properties":[{"key":"GoTerm","value":"P:glial cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"FunFam","id":"1.10.10.500:FF:000002","properties":[{"key":"EntryName","value":"Prospero homeobox 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.500","properties":[{"key":"EntryName","value":"Homeo-prospero domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023082","properties":[{"key":"EntryName","value":"Homeo_prospero_dom"}]},{"database":"InterPro","id":"IPR037131","properties":[{"key":"EntryName","value":"Homeo_prospero_dom_sf"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR039350","properties":[{"key":"EntryName","value":"Prospero_homeodomain"}]},{"database":"PANTHER","id":"PTHR12198:SF0","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN PROSPERO"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12198","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05044","properties":[{"key":"EntryName","value":"HPD"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51818","properties":[{"key":"EntryName","value":"HOMEO_PROSPERO"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRRMSSLEASSGLQSHNTTCRSVKQGRRNSVVETVGEGPTSLTGLENRPGEYQGIFQPREGYQSLQQQNTTASCPGSYPLVSLDFKSHLQVGQRIYQDDTGVGYTTMRESMETCTESESQLCRPSEHGMHLTQSSDEDSQPAENNNKCLQQDKLHEAAGALSKHRDRLGTGLPSETSKLLKDILQHKDRRLRDNNNSLKALMVNGEGKDSSDLIAQLLKNNSSFNTSPMMDDRDGSSRLAAVADSESDSDQESYSGRCQFTGEEDIAEIEAMEGDMKDSSGDERRWGSDSYDVVGQSGKECDSVEAKRARVENIITSMRPSPSGLGGDAGSQLSPDMRRPKRKQYQPQQHDSKHTPTTHSSPKYRKVEERDKLKEQLKHLQKTLHQMQRQYDLFDEEDKMAGQSSSRLNKDSKYIDLLSDTLLIKREDTEPCRNVNFNPSGFDANRIIKQATKLVHAQERSNKDCVSVEKEGLKDLASMLKCEIVDAVGSAIDGVVTRFLQTSPKTQKNDNHTSSSTKNVEKENKPAEDMTPRPSEVPTISAAQETDSIRENRASKPPKVHDKPEKFDKYDRFESKPYLDTPMRGFLDMARAHQNHSHLSPYPHLSYYLPSPIHHPPSLMFGVEPEQTEALPLVVSTPKKKRTKVTDTRLSPRAARALLQESVPMSGHSDMQMSRHSPGSYPHVFPMLPTTVAIPNPGLQHSDILRFYEEQRAFQEANHSSTQSPLQADQGSPGASHISASEGAHLSNGKREQDSYSPNEMSYDPSYHMTITLTPMHLRKAKLMFFYVRYPSSAILKMYFPDIKFNKNNTAQLVKWFSNFREFFYIQMEKYSRQAIAEGVKTGEDLVVTLDSELYRVLNLHYNRNNQLDVPESFRMVVQGTLREFFKSIYGGKDTEQSWKKSIYKVIARMDDIIPEYFKSPNWMEQLGEM","length":930,"molWeight":105193,"crc64":"60911B19C185A5E7","md5":"12048ACF4CF96E4C11F0D8DC6415B146"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":7,"Compositional bias":7},"uniParcId":"UPI00076325DA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A110AS48","uniProtkbId":"A0A110AS48_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2025-06-18","lastSequenceUpdateDate":"2016-04-13","entryVersion":38,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26741.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26741.1"}],"value":"Sine oculis homeobox 1/2"}}],"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000682"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008161"}],"value":"Belongs to the SIX/Sine oculis homeobox family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50071"}]},{"type":"DNA binding","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":235,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":236,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26741.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023155"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0371","category":"Domain","name":"Homeobox"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26741.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193731","properties":[{"key":"ProteinId","value":"AMB26741.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A110AS48","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000063","properties":[{"key":"EntryName","value":"SIX homeobox 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR017970","properties":[{"key":"EntryName","value":"Homeobox_CS"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR031701","properties":[{"key":"EntryName","value":"SIX1_SD"}]},{"database":"PANTHER","id":"PTHR10390","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN SIX"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10390:SF61","properties":[{"key":"EntryName","value":"HOMEOBOX PROTEIN SIX2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00046","properties":[{"key":"EntryName","value":"Homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16878","properties":[{"key":"EntryName","value":"SIX1_SD"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00027","properties":[{"key":"EntryName","value":"HOMEOBOX_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"PGQRTSTLGSPAEVSMLQDQAIPGVPSPTPSMVPSFGFTQEQVACVCEVLQQGGNIERLARFLWSLPACEHLHKNESVLKAKAVVAFHRGNFKELYKILDQNSFAQHNHPKLQALWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRNALKEWYTHNPYPSPREKRELAEGTGLTTTQVSNWFKNRRQRDRAAEQKERFGDQHSQGSLKDQASPTTDGSKEDSLGGFPSKHEDGGSSPDQPIDHSHVYAELQRPSPIQHAHHHDTVHANSMLSGSHHLATPVGHHHHHHHPGLLHHGVPISNGHGTDLSHVMGDYQTL","length":336,"molWeight":37682,"crc64":"7B725198EA7AB6F5","md5":"7E91157192D927CE66B6BD17AC0AD000"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"DNA binding":1,"Region":2,"Compositional bias":5,"Non-terminal residue":1},"uniParcId":"UPI000763237D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A110ASR5","uniProtkbId":"A0A110ASR5_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-04-13","entryVersion":50,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26739.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26739.1"}],"value":"Pax6"}}],"flag":"Fragment"},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000682"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005733"}],"value":"Belongs to the paired homeobox family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Paired","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51057"}]},{"type":"Domain","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50071"}]},{"type":"DNA binding","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Paired","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00381"}]},{"type":"DNA binding","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Homeobox","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}]},{"type":"Region","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"PAI subdomain","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00381"}]},{"type":"Region","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"RED subdomain","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00381"}]},{"type":"Region","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26739.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022473"}],"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023155"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0371","category":"Domain","name":"Homeobox"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00108"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022724"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00381"}],"id":"KW-0563","category":"Domain","name":"Paired box"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00381"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00381"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26739.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193729","properties":[{"key":"ProteinId","value":"AMB26739.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A110ASR5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030154","properties":[{"key":"GoTerm","value":"P:cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0090596","properties":[{"key":"GoTerm","value":"P:sensory organ morphogenesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0048731","properties":[{"key":"GoTerm","value":"P:system development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00086","properties":[{"key":"EntryName","value":"homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00131","properties":[{"key":"EntryName","value":"PAX"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000003","properties":[{"key":"EntryName","value":"Paired box protein Pax-6"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000069","properties":[{"key":"EntryName","value":"Paired box protein Pax-6"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.60:FF:000516","properties":[{"key":"EntryName","value":"Transcription factor Toy"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001356","properties":[{"key":"EntryName","value":"HD"}]},{"database":"InterPro","id":"IPR017970","properties":[{"key":"EntryName","value":"Homeobox_CS"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR043182","properties":[{"key":"EntryName","value":"PAIRED_DNA-bd_site"}]},{"database":"InterPro","id":"IPR001523","properties":[{"key":"EntryName","value":"Paired_dom"}]},{"database":"InterPro","id":"IPR043565","properties":[{"key":"EntryName","value":"PAX_fam"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR45636:SF41","properties":[{"key":"EntryName","value":"PAIRED BOX PROTEIN PAX-6-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45636","properties":[{"key":"EntryName","value":"PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00046","properties":[{"key":"EntryName","value":"Homeodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00292","properties":[{"key":"EntryName","value":"PAX"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00027","properties":[{"key":"EntryName","value":"PAIREDBOX"}]},{"database":"SMART","id":"SM00389","properties":[{"key":"EntryName","value":"HOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00351","properties":[{"key":"EntryName","value":"PAX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00027","properties":[{"key":"EntryName","value":"HOMEOBOX_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50071","properties":[{"key":"EntryName","value":"HOMEOBOX_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00034","properties":[{"key":"EntryName","value":"PAIRED_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51057","properties":[{"key":"EntryName","value":"PAIRED_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVASSGKLTADGFSVSVALSPGIERFTTAALLSDPSHDSTIMPSKEEEKKARPKRGECSTSHSFQRDFGHSGVNQLGGVFVNGRPLPDSTRQRIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVTKIAQYKRECPSIFAWEIRDRLLADSVCNQDNIPSVSSINRVLRNLASENQKVMGQGTMYDKLGLLNGQAWPRHNPWYAPNASMHGLTSSPYQPAPPPPPQNNSSISGGKKEPHHHLHDTSSVHSDHSNDAPQNGESEEQMRIRLKRKLQRNRTSFTASQIESLEKEFERTHYPDVFARERLAQKIDLPEARIQVWFSNRRAKWRREEKLRNQRREAANGTSRIPINSSFANSMYPSIHQPIGSMADSYRFDSQSTIPSVPSYSLSNNIAPNPACLQSTNSSSYSCMIPDYMSGSARSYDPLALSSYSRPPCNPAVGMQSHMNHSAHNGASTG","length":482,"molWeight":53311,"crc64":"2FE6C98CF9072927","md5":"A61964291431CDBEEB292DB315892087"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"DNA binding":2,"Region":4,"Compositional bias":2,"Non-terminal residue":1},"uniParcId":"UPI000762E52D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A125QZC8","uniProtkbId":"A0A125QZC8_9MOLL","entryAudit":{"firstPublicDate":"2016-04-13","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2016-04-13","entryVersion":38,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26738.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26738.1"}],"value":"Ovo"}}]},"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"C2H2-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50157"}]},{"type":"Domain","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"C2H2-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50157"}]},{"type":"Domain","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"C2H2-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50157"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00042"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"26702352","citationType":"journal article","authors":["Voecking O.","Kourtesis I.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"26702352"}],"title":"Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians.","publicationDate":"2015","journal":"Evodevo","firstPage":"40","lastPage":"40","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AMB26738.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU193728","properties":[{"key":"ProteinId","value":"AMB26738.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A125QZC8","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0009887","properties":[{"key":"GoTerm","value":"P:animal organ morphogenesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0003006","properties":[{"key":"GoTerm","value":"P:developmental process involved in reproduction"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009913","properties":[{"key":"GoTerm","value":"P:epidermal cell differentiation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0048731","properties":[{"key":"GoTerm","value":"P:system development"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"3.30.160.60:FF:000246","properties":[{"key":"EntryName","value":"Transcription factor Ovo-like 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.60:FF:000452","properties":[{"key":"EntryName","value":"Transcription factor Ovo-like 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR027756","properties":[{"key":"EntryName","value":"Ovo-like"}]},{"database":"InterPro","id":"IPR013087","properties":[{"key":"EntryName","value":"Zf-C2H2_type"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"PANTHER","id":"PTHR10032:SF271","properties":[{"key":"EntryName","value":"RH12261P-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10032","properties":[{"key":"EntryName","value":"ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00096","properties":[{"key":"EntryName","value":"zf-C2H2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00355","properties":[{"key":"EntryName","value":"ZnF_C2H2"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00028","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50157","properties":[{"key":"EntryName","value":"ZINC_FINGER_C2H2_2"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MPRSLMVRKNGKCKHKKPSVSLRDGEISMDTHHSDSGFHSGFEKSIISSNMDISSNVDSGRVDCVDSGRVDCDADRISPPRADSAGDSPEPPEQSRSEAGQIIPEPKLNGVTALLTTRRAISPIPYPVTSPVTPVTPHHSRVVTYGYSTPYGRPRFASAYLDERTESTAASSLLQLSRLTPPSVDPLHSPQFDVENVKPAMLEPISPPLTASTPLSFLNYRHIPAPIYNPMLSPYIPSGKPYIQPMRANPLPLHLGASSLQAACLSPIPAPRFQPSDSMHAENPAAKILAPTMSRMQPTSPPTSVAVMQRPSIGNYELINGGFGIKNPMLNHVKSAIDSSSTEMGVQMADNKFVCTVCNKVFPLQRLLNRHVKCHSEIKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCELCDKAFTQRCSLESHCRKVHSVSYEFAYKQRRNKMYVCEECGHTTNEPEAHYVHLKDNHPHSPALLKCYDKRQFKFNNTRVPSVLQPVNGR","length":503,"molWeight":55853,"crc64":"CD421524C243A850","md5":"20B865F364314221C9CC7FDDA7A4409B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":3,"Region":2,"Compositional bias":3},"uniParcId":"UPI0007631B1B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A288XNJ2","uniProtkbId":"A0A288XNJ2_9MOLL","entryAudit":{"firstPublicDate":"2017-12-20","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2017-12-20","entryVersion":26,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ASM47584.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369003"}],"value":"ADP-ribosylation factor"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ASM47584.1"}],"value":"Arf4B"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369003"}],"value":"GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004555"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369003"}],"value":"Golgi apparatus","id":"SL-0132"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010290"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003925"}],"value":"Belongs to the small GTPase superfamily. Arf family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Binding site","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606689-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606689-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606689-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606689-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606689-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022892"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369003"}],"id":"KW-0931","category":"Biological process","name":"ER-Golgi transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023034"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369003"}],"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606689-1"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369003"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606689-2"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606689-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022707"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369003"}],"id":"KW-0519","category":"PTM","name":"Myristate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606689-1"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022927"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369003"}],"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU369003"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"28876222","citationType":"journal article","authors":["Vocking O.","Kourtesis I.","Tumu S.C.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"28876222"}],"title":"Co-expression of xenopsin and rhabdomeric opsin in photoreceptors bearing microvilli and cilia.","publicationDate":"2017","journal":"Elife","firstPage":"e23435","lastPage":"e23435","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ASM47584.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MF133504","properties":[{"key":"ProteinId","value":"ASM47584.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A288XNJ2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016192","properties":[{"key":"GoTerm","value":"P:vesicle-mediated transport"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd04150","properties":[{"key":"EntryName","value":"Arf1_5_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000024","properties":[{"key":"EntryName","value":"ADP-ribosylation factor 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045872","properties":[{"key":"EntryName","value":"Arf1-5-like"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR024156","properties":[{"key":"EntryName","value":"Small_GTPase_ARF"}]},{"database":"InterPro","id":"IPR006689","properties":[{"key":"EntryName","value":"Small_GTPase_ARF/SAR"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11711","properties":[{"key":"EntryName","value":"ADP RIBOSYLATION FACTOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00025","properties":[{"key":"EntryName","value":"Arf"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00328","properties":[{"key":"EntryName","value":"SAR1GTPBP"}]},{"database":"SMART","id":"SM00177","properties":[{"key":"EntryName","value":"ARF"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00178","properties":[{"key":"EntryName","value":"SAR"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51417","properties":[{"key":"EntryName","value":"ARF"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGLTISGLFTRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIGEAREELSKMLSEDELRDAALLVFANKQDLPNAMPATELTDKLGLQQIRGRTWYIQATCATQGTGLYEGLDWLSDKLATGKS","length":182,"molWeight":20451,"crc64":"5C5D9A9F85AE6004","md5":"32C827856548E66AC36136EFCAE33A30"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Binding site":5},"uniParcId":"UPI000BC0DB03"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A288XNJ7","uniProtkbId":"A0A288XNJ7_9MOLL","entryAudit":{"firstPublicDate":"2017-12-20","lastAnnotationUpdateDate":"2025-10-08","lastSequenceUpdateDate":"2017-12-20","entryVersion":22,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptochiton asellus","taxonId":211853,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ASM47585.1"}],"lineage":["Eukaryota","Metazoa","Spiralia","Lophotrochozoa","Mollusca","Polyplacophora","Neoloricata","Lepidopleurida","Lepidopleuridae","Leptochiton"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ASM47585.1"}],"value":"Rab11 family-interacting protein 3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ASM47585.1"}],"value":"FIP3"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004626"}],"value":"Cleavage furrow","id":"SL-0467"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004214"}],"value":"Midbody","id":"SL-0469"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004654"}],"value":"Recycling endosome membrane","id":"SL-0231"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004654"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]}],"features":[{"type":"Domain","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]},{"type":"Domain","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"FIP-RBD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51511"}]},{"type":"Region","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Coiled coil","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022753"}],"id":"KW-0967","category":"Cellular component","name":"Endosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"28876222","citationType":"journal article","authors":["Vocking O.","Kourtesis I.","Tumu S.C.","Hausen H."],"citationCrossReferences":[{"database":"PubMed","id":"28876222"}],"title":"Co-expression of xenopsin and rhabdomeric opsin in photoreceptors bearing microvilli and cilia.","publicationDate":"2017","journal":"Elife","firstPage":"e23435","lastPage":"e23435","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ASM47585.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MF133505","properties":[{"key":"ProteinId","value":"ASM47585.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A0A288XNJ7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0032154","properties":[{"key":"GoTerm","value":"C:cleavage furrow"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030139","properties":[{"key":"GoTerm","value":"C:endocytic vesicle"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030496","properties":[{"key":"GoTerm","value":"C:midbody"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0055038","properties":[{"key":"GoTerm","value":"C:recycling endosome membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0032456","properties":[{"key":"GoTerm","value":"P:endocytic recycling"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0032465","properties":[{"key":"GoTerm","value":"P:regulation of cytokinesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00051","properties":[{"key":"EntryName","value":"EFh"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.2440","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR037245","properties":[{"key":"EntryName","value":"FIP-RBD_C_sf"}]},{"database":"InterPro","id":"IPR019018","properties":[{"key":"EntryName","value":"Rab-bd_FIP-RBD"}]},{"database":"InterPro","id":"IPR057316","properties":[{"key":"EntryName","value":"Rab11-FIP3/4_dom"}]},{"database":"InterPro","id":"IPR051977","properties":[{"key":"EntryName","value":"Rab11-interacting_regulator"}]},{"database":"PANTHER","id":"PTHR15726:SF7","properties":[{"key":"EntryName","value":"NUCLEAR FALLOUT, ISOFORM J"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15726","properties":[{"key":"EntryName","value":"RAB11-FAMILY INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13499","properties":[{"key":"EntryName","value":"EF-hand_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25450","properties":[{"key":"EntryName","value":"Rab11-FIP3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09457","properties":[{"key":"EntryName","value":"RBD-FIP"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF144270","properties":[{"key":"EntryName","value":"Eferin C-derminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51511","properties":[{"key":"EntryName","value":"FIP_RBD"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEDIDVDYTDRLRTVFELCDEQNEGYITVDHFKNQVKELGDFGGEEIVGIVQLLDPEGKGKINFEEFCQGVQQISELHAGFLGPSSPICVHSGQWNFKSPKSALSSTPVHSESSQPLSTIKLIESESIETLVPSSLNHSPSATEISENSNATYNEYDTATDEDASALGLSPTESNLHENKSALSELEFLNLPTHLSEDDRDSAISGRSSEVNSRQDITDEENYEDYGEAGEVDSELDIRSHISDSDLPLTHHSNRKITTAAYANQLHRSSPARRGSFGSDEIYDNIDGSFSEVNDKIEFLQKQISLLTDNYQDSESKHSRQREENTLLVRKIHGLEEQLREIEIKSDEKVMDEQRRQRDFVNRHDRERADQLDYLTQRLQRVEKENDQAQADVTRLKSEVDKLKQEKFEIQERLSEAQYENITVREEEELLREKLKTQNENIEVERQGAAQLMDEMGKELELLRKYKIENELHRNRAESVGDLPARYKDLQAEIRQLQEENRSLRTSNEDLGLQLLSNCMKEGRSLLETQEGISLAEEIEHMDKDQLMSKLKEQQDNNRRLTQYVDRILLTILEKNPSLLEIQQS","length":585,"molWeight":67176,"crc64":"188DE1031D73E251","md5":"79A2A910339E37D17CD1D69C73D752CE"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":2,"Region":1,"Coiled coil":3,"Compositional bias":2},"uniParcId":"UPI000BC02220"}}]}