{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B5A826","uniProtkbId":"B5A826_9PSEU","entryAudit":{"firstPublicDate":"2008-09-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-09-23","entryVersion":62,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Amycolatopsis decaplanina","taxonId":208441,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF49448.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Pseudonocardiales","Pseudonocardiaceae","Amycolatopsis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"DNA topoisomerase (ATP-hydrolyzing)"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012895"}],"value":"5.6.2.2"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF49448.1"}],"value":"gyrB"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP-dependent breakage, passage and rejoining of double-stranded DNA.","ecNumber":"5.6.2.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000185"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010708"}],"value":"Belongs to the type II topoisomerase GyrB family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Histidine kinase/HSP90-like ATPase","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00387"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF49448.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":456,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF49448.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023029"}],"id":"KW-0799","category":"Molecular function","name":"Topoisomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"18803029","citationType":"journal article","authors":["Everest G.J.","Meyers P.R."],"citationCrossReferences":[{"database":"PubMed","id":"18803029"},{"database":"DOI","id":"10.1007/s10482-008-9280-9"}],"title":"The use of gyrB sequence analysis in the phylogeny of the genus Amycolatopsis.","publicationDate":"2009","journal":"Antonie Van Leeuwenhoek","firstPage":"1","lastPage":"11","volume":"95"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF49448.1"}],"value":"NRRL B-24209","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACF49448.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU822891","properties":[{"key":"ProteinId","value":"ACF49448.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B5A826","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0034335","properties":[{"key":"GoTerm","value":"F:DNA negative supercoiling activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006265","properties":[{"key":"GoTerm","value":"P:DNA topological change"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd16928","properties":[{"key":"EntryName","value":"HATPase_GyrB-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00822","properties":[{"key":"EntryName","value":"TopoII_Trans_DNA_gyrase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.230.10:FF:000005","properties":[{"key":"EntryName","value":"DNA gyrase subunit B"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.230.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.670","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.565.10","properties":[{"key":"EntryName","value":"Histidine kinase-like ATPase, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036890","properties":[{"key":"EntryName","value":"HATPase_C_sf"}]},{"database":"InterPro","id":"IPR003594","properties":[{"key":"EntryName","value":"HATPase_dom"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"InterPro","id":"IPR014721","properties":[{"key":"EntryName","value":"Ribsml_uS5_D2-typ_fold_subgr"}]},{"database":"InterPro","id":"IPR001241","properties":[{"key":"EntryName","value":"Topo_IIA"}]},{"database":"InterPro","id":"IPR013760","properties":[{"key":"EntryName","value":"Topo_IIA-like_dom_sf"}]},{"database":"InterPro","id":"IPR000565","properties":[{"key":"EntryName","value":"Topo_IIA_B"}]},{"database":"InterPro","id":"IPR013759","properties":[{"key":"EntryName","value":"Topo_IIA_B_C"}]},{"database":"InterPro","id":"IPR013506","properties":[{"key":"EntryName","value":"Topo_IIA_bsu_dom2"}]},{"database":"InterPro","id":"IPR018522","properties":[{"key":"EntryName","value":"TopoIIA_CS"}]},{"database":"InterPro","id":"IPR006171","properties":[{"key":"EntryName","value":"TOPRIM_dom"}]},{"database":"PANTHER","id":"PTHR45866:SF1","properties":[{"key":"EntryName","value":"DNA GYRASE SUBUNIT B, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45866","properties":[{"key":"EntryName","value":"DNA GYRASE/TOPOISOMERASE SUBUNIT B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00204","properties":[{"key":"EntryName","value":"DNA_gyraseB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02518","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01751","properties":[{"key":"EntryName","value":"Toprim"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01159","properties":[{"key":"EntryName","value":"DNAGYRASEB"}]},{"database":"PRINTS","id":"PR00418","properties":[{"key":"EntryName","value":"TPI2FAMILY"}]},{"database":"SMART","id":"SM00387","properties":[{"key":"EntryName","value":"HATPase_c"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00433","properties":[{"key":"EntryName","value":"TOP2c"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55874","properties":[{"key":"EntryName","value":"ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56719","properties":[{"key":"EntryName","value":"Type II DNA topoisomerase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00177","properties":[{"key":"EntryName","value":"TOPOISOMERASE_II"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LVQEVVDNSVDEAMAGFATKVEVTLLADGGVRVVDDGRGIPVDMHPKEQKPTLEVVLTVLHAGGKFDSDSYAVSGGLHGVGVSVVNALSTKLIAEVKRGGHSWRQVYTDQVPGELEDLGPAEDTGTTITFWADGDIFETTTYNFETISRRLQEMAFLNKGLTLSLRDERVADEETEADASGQAARVKEKTYCYPGGLEDFVKHINGSKDPIHASVISFEAKGTGLEVEVAMQWNNGFTPSVYTFANTINTHEGGTHEEGFRAALTRVVNAYAREKKLLKEKDANLSGDDVREGLAAIVSIKLSEPQFEGQTKTKLGNSEAKTFVQQTSNEWLADWFERNPTEAKTIINKSISSAQARMAARKARDLVRRKGALEIGGLPGKLKDCRSTNPSECELYIVEGDSAGGSAKEGRDSMYQAILPIRGKIINVEKARIDRVLKNTEVQSLITALGTGIHEE","length":456,"molWeight":49617,"crc64":"1B4B6A7ED37CB5BA","md5":"012B2A3A1837D55E76D2FF2897E656E1"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00017AA1B7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F8UBZ3","uniProtkbId":"F8UBZ3_9PSEU","entryAudit":{"firstPublicDate":"2011-09-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-09-21","entryVersion":33,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Amycolatopsis decaplanina","taxonId":208441,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEI72071.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Pseudonocardiales","Pseudonocardiaceae","Amycolatopsis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021315"}],"value":"DNA repair protein RecN"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033408"}],"value":"Recombination protein N"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEI72071.1"}],"value":"recN"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009441"}],"value":"Belongs to the RecN family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEI72071.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEI72071.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"21671192","citationType":"journal article","authors":["Everest G.J.","Cook A.E.","Kirby B.M.","Meyers P.R."],"citationCrossReferences":[{"database":"PubMed","id":"21671192"},{"database":"DOI","id":"10.1007/s10482-011-9604-z"}],"title":"Evaluation of the use of recN sequence analysis in the phylogeny of the genus Amycolatopsis.","publicationDate":"2011","journal":"Antonie Van Leeuwenhoek","firstPage":"483","lastPage":"496","volume":"100"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEI72071.1"}],"value":"NRRL B-24209","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEI72071.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF772781","properties":[{"key":"ProteinId","value":"AEI72071.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"F8UBZ3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0043590","properties":[{"key":"GoTerm","value":"C:bacterial nucleoid"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006310","properties":[{"key":"GoTerm","value":"P:DNA recombination"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006281","properties":[{"key":"GoTerm","value":"P:DNA repair"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0009432","properties":[{"key":"GoTerm","value":"P:SOS response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR004604","properties":[{"key":"EntryName","value":"DNA_recomb/repair_RecN"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR11059","properties":[{"key":"EntryName","value":"DNA REPAIR PROTEIN RECN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11059:SF0","properties":[{"key":"EntryName","value":"DNA REPAIR PROTEIN RECN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"PALGGRAEVSKVRTGMLKAFVEGRFELGGAEGATRIVTDAGAEVDEDGSVIALRAVSVDGRSRAHLGGRSVPVGVLADLSEQLIAVHGQNDQLRLLRPAEQRAVIDRFAGEAVTEPLERYRAVRDEWLAVVAELTERSTRSREMAQQADLLRHGLAEIDAVAPEPGEDTELTEQIKRLAAVDELRGAASAAHAAVAGSPDGDPDAPGALGLIGEATRHLTGSEDAVLRELGPRLDEASVLLSEVGTELGSYLETLDADPALLEKVLARQADLKRLTRKYAADVDGVLAWADDARRRMSTMDTSEEALAELAKRRDELAVTLAEHALTLSEARVEAAAELAEAITAEMSGLAMGQAEIEITVERRTVDESDAHAVKVDGRLVHAGPDGVDDVELLLRAHNGAPPLPVHKAASGGELSRVMLAIEVVLAHADTGR","length":433,"molWeight":45857,"crc64":"4D91EA736A09BE73","md5":"954BA8BC7B24493076543ABEEDAF70FF"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI0002148417"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E5KCN5","uniProtkbId":"E5KCN5_9PSEU","entryAudit":{"firstPublicDate":"2011-02-08","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2011-02-08","entryVersion":9,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Amycolatopsis decaplanina","taxonId":208441,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89931.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Pseudonocardiales","Pseudonocardiaceae","Amycolatopsis"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89931.1"}],"value":"Type-II polyketide synthase KSI"}}],"flag":"Fragment"},"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89931.1"}]}],"references":[{"referenceNumber":1,"citation":{"id":"21615633","citationType":"journal article","authors":["Everest G.J.","Meyers P.R."],"citationCrossReferences":[{"database":"PubMed","id":"21615633"},{"database":"DOI","id":"10.1111/j.1365-2672.2011.05058.x"}],"title":"Evaluation of the antibiotic biosynthetic potential of the genus Amycolatopsis and description of Amycolatopsis circi sp. nov., Amycolatopsis equina sp. nov. and Amycolatopsis hippodromi sp. nov.","publicationDate":"2011","journal":"J. Appl. Microbiol.","firstPage":"300","lastPage":"311","volume":"111"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89931.1"}],"value":"NRRL B-24209","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89931.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ021217","properties":[{"key":"ProteinId","value":"ADP89931.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]}],"sequence":{"value":"GGFQSAVILERAA","length":13,"molWeight":1318,"crc64":"DE46C782DBBB42CD","md5":"E9C2971D91C3D60B20498160433E4E53"},"extraAttributes":{"countByFeatureType":{"Non-terminal residue":1},"uniParcId":"UPI0001F24FC2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E5KCN6","uniProtkbId":"E5KCN6_9PSEU","entryAudit":{"firstPublicDate":"2011-02-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-02-08","entryVersion":40,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Amycolatopsis decaplanina","taxonId":208441,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89932.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Pseudonocardiales","Pseudonocardiaceae","Amycolatopsis"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89932.1"}],"value":"Type-II polyketide synthase KSII"}}],"flag":"Fragment"},"features":[{"type":"Domain","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Beta-ketoacyl synthase-like N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00109"}]},{"type":"Non-terminal residue","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89932.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023315"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"21615633","citationType":"journal article","authors":["Everest G.J.","Meyers P.R."],"citationCrossReferences":[{"database":"PubMed","id":"21615633"},{"database":"DOI","id":"10.1111/j.1365-2672.2011.05058.x"}],"title":"Evaluation of the antibiotic biosynthetic potential of the genus Amycolatopsis and description of Amycolatopsis circi sp. nov., Amycolatopsis equina sp. nov. and Amycolatopsis hippodromi sp. nov.","publicationDate":"2011","journal":"J. Appl. Microbiol.","firstPage":"300","lastPage":"311","volume":"111"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89932.1"}],"value":"NRRL B-24209","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ADP89932.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HQ021217","properties":[{"key":"ProteinId","value":"ADP89932.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"E5KCN6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004315","properties":[{"key":"GoTerm","value":"F:3-oxoacyl-[acyl-carrier-protein] synthase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006633","properties":[{"key":"GoTerm","value":"P:fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"3.40.47.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000794","properties":[{"key":"EntryName","value":"Beta-ketoacyl_synthase"}]},{"database":"InterPro","id":"IPR014030","properties":[{"key":"EntryName","value":"KAS_N"}]},{"database":"InterPro","id":"IPR016039","properties":[{"key":"EntryName","value":"Thiolase-like"}]},{"database":"PANTHER","id":"PTHR11712:SF322","properties":[{"key":"EntryName","value":"POLYKETIDE BETA-KETOACYL SYNTHASE 2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11712","properties":[{"key":"EntryName","value":"POLYKETIDE SYNTHASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00109","properties":[{"key":"EntryName","value":"ketoacyl-synt"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53901","properties":[{"key":"EntryName","value":"Thiolase-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSTGVRAVITGIGVVAPNGLSTEDYWSATVKGRSGLDRINRFEPSRYPVRVAGEISSFTPEEHLPNRLLPQTDRVTQLALTASDSALRDAGLSTETLPDYAMGVVTSTAAGGFEFGQGELAKLWGK","length":126,"molWeight":13413,"crc64":"733EB39F861A65F8","md5":"72CBE3DB9992F20497CFFE405A65F4A3"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":1},"uniParcId":"UPI0001F24FC3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G1APT1","uniProtkbId":"G1APT1_9PSEU","entryAudit":{"firstPublicDate":"2011-10-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-10-19","entryVersion":30,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Amycolatopsis decaplanina","taxonId":208441,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM24399.1"}],"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Pseudonocardiales","Pseudonocardiaceae","Amycolatopsis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM24399.1"}],"value":"Glycopeptide monooxygenase B"}}],"flag":"Fragment"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010617"}],"value":"Belongs to the cytochrome P450 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM24399.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM24399.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM24399.1"}],"id":"KW-0503","category":"Molecular function","name":"Monooxygenase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM24399.1"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"}],"references":[{"referenceNumber":1,"citation":{"id":"21615633","citationType":"journal article","authors":["Everest G.J.","Meyers P.R."],"citationCrossReferences":[{"database":"PubMed","id":"21615633"},{"database":"DOI","id":"10.1111/j.1365-2672.2011.05058.x"}],"title":"Evaluation of the antibiotic biosynthetic potential of the genus Amycolatopsis and description of Amycolatopsis circi sp. nov., Amycolatopsis equina sp. nov. and Amycolatopsis hippodromi sp. nov.","publicationDate":"2011","journal":"J. Appl. Microbiol.","firstPage":"300","lastPage":"311","volume":"111"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM24399.1"}],"value":"NRRL B-24209","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEM24399.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF416940","properties":[{"key":"ProteinId","value":"AEM24399.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"G1APT1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005506","properties":[{"key":"GoTerm","value":"F:iron ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004497","properties":[{"key":"GoTerm","value":"F:monooxygenase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016705","properties":[{"key":"GoTerm","value":"F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.630.10","properties":[{"key":"EntryName","value":"Cytochrome P450"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002397","properties":[{"key":"EntryName","value":"Cyt_P450_B"}]},{"database":"InterPro","id":"IPR036396","properties":[{"key":"EntryName","value":"Cyt_P450_sf"}]},{"database":"PANTHER","id":"PTHR46696:SF1","properties":[{"key":"EntryName","value":"CYTOCHROME P450 YJIB-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46696","properties":[{"key":"EntryName","value":"P450, PUTATIVE (EUROFUNG)-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00359","properties":[{"key":"EntryName","value":"BP450"}]},{"database":"SUPFAM","id":"SSF48264","properties":[{"key":"EntryName","value":"Cytochrome P450"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"RQKLNPGFTLRKMQRMGPYIEQIVTERLDELEQAGSPADLVAIVADKVPGAVLCELIGVPRDDRATFLQLCHAHLDASRSQKRRAVAGEAFSRYLLAMIARERKEPGEGLIGAVVAEYGDEATDEELRGFCVQVMLAGDDNISGMIGLGVLALLRNPGQIAALQGGE","length":167,"molWeight":18057,"crc64":"7C648D37A09D6973","md5":"649BED1DEB167F835220B327554CAA48"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00021E3C40"}}]}