{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT8","uniProtkbId":"A0A347ZJT8_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-11-07","entryVersion":36,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85503.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015947"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Cytochrome c oxidase subunit 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012949"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"7.1.1.9"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85503.1"}],"value":"COI"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Cu cation","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001935"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:23378"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001971"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004673"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Energy metabolism; oxidative phosphorylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009578"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Belongs to the heme-copper respiratory oxidase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit I profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50855"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85503.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023053"}],"id":"KW-0915","category":"Ligand","name":"Sodium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85503.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85503.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85503.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT8","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00705","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01663","properties":[{"key":"EntryName","value":"Cyt_c_Oxidase_I"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.210.10:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.210.10","properties":[{"key":"EntryName","value":"Cytochrome c oxidase-like, subunit I domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023616","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_dom"}]},{"database":"InterPro","id":"IPR036927","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_sf"}]},{"database":"InterPro","id":"IPR000883","properties":[{"key":"EntryName","value":"Cyt_C_Oxase_1"}]},{"database":"InterPro","id":"IPR023615","properties":[{"key":"EntryName","value":"Cyt_c_Oxase_su1_BS"}]},{"database":"InterPro","id":"IPR033944","properties":[{"key":"EntryName","value":"Cyt_c_oxase_su1_dom"}]},{"database":"PANTHER","id":"PTHR10422","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10422:SF18","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00115","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01165","properties":[{"key":"EntryName","value":"CYCOXIDASEI"}]},{"database":"SUPFAM","id":"SSF81442","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit I-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50855","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00077","properties":[{"key":"EntryName","value":"COX1_CUB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMITRWLFSTNHKDIGTLYFMFGAWAGMVGTALSLLIRAELSQPGTLLGNDQFYNVIVTAHAFVMIFFMVMPVMIGGFGNWLVPMMIGAPDMAFPRMNNMSFWLLPPALLLLLASSGVEGGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILGAINFISTIINMKSPIVTQYRTPLFVWSVLVTAILLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIIAYYSGKKEPFGYMGMVWAMMTIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGVIKWETPMLWALGFIFLFTIGGLTGIVLANSSIDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFTGFSLHPKWTKVHFGIMFLGVNLTFFPQHFLGLAGMPRRYSDYPDAYAMWNLLSSIGSLISLTAVVLFMFILWEAFATKRLIKWVHITGTNMEWLQGSPPPSHTFEDFPLVRIQSYWSVRMSRLNKVI","length":528,"molWeight":58773,"crc64":"8A7E26DD1DEDC0A3","md5":"134762C8219449F903C83253F2A63B34"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":2,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":12,"Domain":1},"uniParcId":"UPI000DF5C47A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT0","uniProtkbId":"A0A347ZJT0_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-11-07","entryVersion":33,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85495.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021009"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"value":"NADH-ubiquinone oxidoreductase chain 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85495.1"}],"value":"ND1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010535"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"value":"Belongs to the complex I subunit 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85495.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85495.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000471"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000473"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85495.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85495.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85495.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009510314.1","properties":[{"key":"NucleotideSequenceId","value":"NC_039137.1"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT0","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"37622625","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4535","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0009060","properties":[{"key":"GoTerm","value":"P:aerobic respiration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"HAMAP","id":"MF_01350","properties":[{"key":"EntryName","value":"NDH1_NuoH"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001694","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_su1/FPO"}]},{"database":"InterPro","id":"IPR018086","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_su1_CS"}]},{"database":"PANTHER","id":"PTHR11432","properties":[{"key":"EntryName","value":"NADH DEHYDROGENASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11432:SF3","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00146","properties":[{"key":"EntryName","value":"NADHdh"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00667","properties":[{"key":"EntryName","value":"COMPLEX1_ND1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00668","properties":[{"key":"EntryName","value":"COMPLEX1_ND1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKYIIIFIISPLMYIVPVLLAVAFLTLLERKVLGYMQMRKGPNIVGPFGLLQPVADGIKLFIKEPVRPSTSNSLLFIVAPTLALTLALTLWTPMPMPYPMMELSLGILFMLALSSLAVYSILASGWASNSKYALMGALRAVAQTISYEVCLGLIILSVIMTVGGFNLKMLNNIQETMWLIVPMWPMAAVWYTSTLAETNRAPFDLTEGESELVSGFNVEYAGGPFALFFLAEYSNILMMNMFSTIIFLGSTYPHQTPELATMTLAMKTVLLSCLFLWVRGSYPRFRYDQLMFLVWKNFLPLTLALLIWNLSLLTMMAGLPTL","length":322,"molWeight":35980,"crc64":"C1E33439683A76CA","md5":"7CB17E69BD13065A9B283EC20C549D67"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":8},"uniParcId":"UPI000DF5F2E4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT1","uniProtkbId":"A0A347ZJT1_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-11-07","entryVersion":21,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85496.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"value":"ATP synthase complex subunit 8"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85496.1"}],"value":"ATP8"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00053067"}],"value":"Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094686"}],"value":"Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctamer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004304"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004304"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008892"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"value":"Belongs to the ATPase protein 8 family"}],"commentType":"SIMILARITY"}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85496.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023310"}],"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022547"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003661"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85496.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85496.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85496.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009510315.1","properties":[{"key":"NucleotideSequenceId","value":"NC_039137.1"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"37622627","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4509","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0015078","properties":[{"key":"GoTerm","value":"F:proton transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015986","properties":[{"key":"GoTerm","value":"P:proton motive force-driven ATP synthesis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR001421","properties":[{"key":"EntryName","value":"ATP8"}]},{"database":"InterPro","id":"IPR050635","properties":[{"key":"EntryName","value":"ATPase_protein_8"}]},{"database":"PANTHER","id":"PTHR39937","properties":[{"key":"EntryName","value":"ATP SYNTHASE PROTEIN 8"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39937:SF1","properties":[{"key":"EntryName","value":"ATP SYNTHASE PROTEIN 8"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00895","properties":[{"key":"EntryName","value":"ATP-synt_8"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPQLNPSPWLKVATLSWIAYAVVLPPKILKLVFDNDPNQTNSCPTQQTPWNWPWL","length":55,"molWeight":6359,"crc64":"59115E85891B842E","md5":"979484521059BE7D7621B645D0FC9894"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"uniParcId":"UPI000DF5EDC0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT2","uniProtkbId":"A0A347ZJT2_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-11-07","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85497.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004450"}],"value":"ATP synthase subunit a"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85497.1"}],"value":"ATP6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"H(+)(in) = H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34979"},{"database":"ChEBI","id":"CHEBI:15378"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024169"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094784"}],"value":"Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctamer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Interacts with DNAJC30; interaction is direct"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004141"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004450"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004450"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006810"}],"value":"Belongs to the ATPase A chain family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85497.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023310"}],"id":"KW-0066","category":"Biological process","name":"ATP synthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022547"}],"id":"KW-0138","category":"Cellular component","name":"CF(0)"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022781"}],"id":"KW-0375","category":"Biological process","name":"Hydrogen ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85497.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85497.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85497.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85497.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009510316.1","properties":[{"key":"NucleotideSequenceId","value":"NC_039137.1"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT2","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"37622610","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4508","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045259","properties":[{"key":"GoTerm","value":"C:proton-transporting ATP synthase complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046933","properties":[{"key":"GoTerm","value":"F:proton-transporting ATP synthase activity, rotational mechanism"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00310","properties":[{"key":"EntryName","value":"ATP-synt_Fo_a_6"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.220","properties":[{"key":"EntryName","value":"ATP synthase, F0 complex, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000568","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu"}]},{"database":"InterPro","id":"IPR045083","properties":[{"key":"EntryName","value":"ATP_synth_F0_asu_bact/mt"}]},{"database":"InterPro","id":"IPR035908","properties":[{"key":"EntryName","value":"F0_ATP_A_sf"}]},{"database":"NCBIfam","id":"TIGR01131","properties":[{"key":"EntryName","value":"ATP_synt_6_or_A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11410","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11410:SF0","properties":[{"key":"EntryName","value":"ATP SYNTHASE SUBUNIT A"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00119","properties":[{"key":"EntryName","value":"ATP-synt_A"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00123","properties":[{"key":"EntryName","value":"ATPASEA"}]},{"database":"SUPFAM","id":"SSF81336","properties":[{"key":"EntryName","value":"F1F0 ATP synthase subunit A"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTMDLFHQFTPNIIPLTVMLLLPLTVLLPYSFQWLGGRIVTLKIWIIKQLTSQILSPLSRVGHKWALVLMALIVFLMTLNVLGMLPYTFTPTTQLAVNLGFAIPLWLATITLGARKKPVQFTAHVLPLGTPLPLIPVLVLIETVSMIVRPFALGVRITANLVAGHLLIQLSSMATASLVSSTLVAAVLVSSTVVLLTALEVAVALIQAYVYVLLVSLYLKENT","length":223,"molWeight":24317,"crc64":"24386743ADFE33AA","md5":"BA8B76540C40A58C1269EFC6CEF57A7E"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":5},"uniParcId":"UPI000DF6246A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT3","uniProtkbId":"A0A347ZJT3_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2018-11-07","entryVersion":25,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85498.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"value":"Cytochrome c oxidase subunit 3"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85498.1"}],"value":"COIII"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094728"}],"value":"Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and COXFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2))"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010581"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"value":"Belongs to the cytochrome c oxidase subunit 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Heme-copper oxidase subunit III family profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50253"}]},{"type":"Region","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85498.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003375"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85498.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85498.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85498.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01665","properties":[{"key":"EntryName","value":"Cyt_c_Oxidase_III"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.70:FF:000048","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.80:FF:000002","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.80","properties":[{"key":"EntryName","value":"Cytochrome c oxidase, subunit III, four-helix bundle"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024791","properties":[{"key":"EntryName","value":"Cyt_c/ubiquinol_Oxase_su3"}]},{"database":"InterPro","id":"IPR033945","properties":[{"key":"EntryName","value":"Cyt_c_oxase_su3_dom"}]},{"database":"InterPro","id":"IPR000298","properties":[{"key":"EntryName","value":"Cyt_c_oxidase-like_su3"}]},{"database":"InterPro","id":"IPR035973","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su3-like_sf"}]},{"database":"InterPro","id":"IPR013833","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su3_a-hlx"}]},{"database":"PANTHER","id":"PTHR11403:SF7","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11403","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT III"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00510","properties":[{"key":"EntryName","value":"COX3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81452","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit III-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50253","properties":[{"key":"EntryName","value":"COX3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSGRYHPYYTVKLSPQQLEEQKKSQLIREQKSSQPLKKQKSSEPLEKQKSSEPLVKQKAPQNHPYHMVNPSPWPLTGAAAALMLTSGTAMWFHYQKMALINLGLLMLLLTMFQWWRDIVREGTFQGHHTPQVQKGLRYGMVLFITSEIFFFLGFFWAFYHSSLAPTPELGGCWPPTGISPLNPFDVPLLNTIVLLASGVTVTWAHHSLMNEKREQAIQSLTMTVLLGMYFTMLQAAEYCETSFTMADSTYGSTFFVATGFHGLHVLIGTLFLMVCLSRQIKFQFTSHHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS","length":318,"molWeight":36564,"crc64":"BDF6F7E53E80E598","md5":"8A27BA1D6A51EDCCB98F4044EB33D05D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":7,"Domain":1,"Region":1,"Compositional bias":2},"uniParcId":"UPI000DF5EC0D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT4","uniProtkbId":"A0A347ZJT4_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-11-07","entryVersion":26,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85499.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021007"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"NADH-ubiquinone oxidoreductase chain 3"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85499.1"}],"value":"ND3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008472"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"value":"Belongs to the complex I subunit 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]},{"type":"Transmembrane","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]},{"type":"Transmembrane","location":{"start":{"value":88,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85499.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003640"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85499.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85499.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85499.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009510318.1","properties":[{"key":"NucleotideSequenceId","value":"NC_039137.1"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT4","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"37622628","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4537","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030964","properties":[{"key":"GoTerm","value":"C:NADH dehydrogenase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"FunFam","id":"1.20.58.1610:FF:000004","properties":[{"key":"EntryName","value":"NADH-quinone oxidoreductase subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1610","properties":[{"key":"EntryName","value":"NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000440","properties":[{"key":"EntryName","value":"NADH_UbQ/plastoQ_OxRdtase_su3"}]},{"database":"InterPro","id":"IPR038430","properties":[{"key":"EntryName","value":"NDAH_ubi_oxred_su3_sf"}]},{"database":"PANTHER","id":"PTHR11058","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11058:SF9","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00507","properties":[{"key":"EntryName","value":"Oxidored_q4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNLMMSTLIVTGSLAYLLIVISFWLPQMSPNAIKLSPYECGFDPTGSARIPFSIRFFLVGVLFLLFDLEIALLLPITWGGQLSDTLAMFSWVISIIIIMTLGLTYEWVQGGLEWAE","length":116,"molWeight":12981,"crc64":"ACA38326856773C0","md5":"25A8E0398E8CDE29D2B318386544E740"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":3},"uniParcId":"UPI000DF63475"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT5","uniProtkbId":"A0A347ZJT5_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-11-07","entryVersion":37,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85500.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021096"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"NADH-ubiquinone oxidoreductase chain 5"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85500.1"}],"value":"ND5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"value":"Belongs to the complex I subunit 5 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Transmembrane","location":{"start":{"value":589,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}]},{"type":"Domain","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00662"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]},{"type":"Domain","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"NADH dehydrogenase subunit 5 C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF06455"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85500.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003404"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85500.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85500.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85500.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009510319.1","properties":[{"key":"NucleotideSequenceId","value":"NC_039137.1"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT5","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"37622629","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4540","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR010934","properties":[{"key":"EntryName","value":"NADH_DH_su5_C"}]},{"database":"InterPro","id":"IPR018393","properties":[{"key":"EntryName","value":"NADHpl_OxRdtase_5_subgr"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"InterPro","id":"IPR003945","properties":[{"key":"EntryName","value":"NU5C-like"}]},{"database":"InterPro","id":"IPR001516","properties":[{"key":"EntryName","value":"Proton_antipo_N"}]},{"database":"NCBIfam","id":"TIGR01974","properties":[{"key":"EntryName","value":"NDH_I_L"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42829","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42829:SF2","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06455","properties":[{"key":"EntryName","value":"NADH5_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00662","properties":[{"key":"EntryName","value":"Proton_antipo_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01434","properties":[{"key":"EntryName","value":"NADHDHGNASE5"}]}],"sequence":{"value":"MPATHVMINSSMLTMAAVIMYLPLTSMLSPNMVKKTTKHVKVVIQMAFFISLIPLLLFLDQGMETTLTNWQWFNTAMFNLNMSFKFDQYSIIFIPVALYVTWSILEFTLWYMASDPNINRFFNYMLVFLIAMIVLVTANNLFQLFIGWEGVGIMSFLLIGWWHGRSDANTAALQAVIYNRVGDVGFVMAMAWMALNINSWEMQQMFMMSKEINMTLPIVGFIMAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRLHPLMSNNPTALSLCLCSGALTTLFTATCALTQNDIKKIIAFSTSSQLGLMMVTIGLNQPQLAFIHICTHAFFKAMLFLCSGVVIHSLNDEQDIRKMGGLHKMLPLTSSCILLGSLALTGTPFLTGFYSKDAIIEAMNTSHLNAWALTLTLIATSFTAAYSLRIIFFTSMKYPRLMSLNPINENNPSVINPIKRLAWGSMIAGLMITLNFLFIKTPNMTMSPTLKMSALLVTAVGLMTAIEMTTLTNKQHKIFPNMKMGGFSNMLGFFPTLTHRMGPKLVLTMGQKMASHMSDQTWFESLGPKSMQNKQLFMVKFVSSPQQGLIKVYLTMFLLTGIMAVLLMS","length":610,"molWeight":68004,"crc64":"B8A1B56B134C0AE0","md5":"F2D6C184B3F66B499FD02E943228ECFD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":16,"Domain":3},"uniParcId":"UPI000DF60684"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT6","uniProtkbId":"A0A347ZJT6_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-11-07","entryVersion":19,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85501.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021095"}],"value":"NADH-ubiquinone oxidoreductase chain 6"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"}],"value":"7.1.1.2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031019"}],"value":"NADH dehydrogenase subunit 6"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85501.1"}],"value":"ND6"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005698"}],"value":"Belongs to the complex I subunit 6 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85501.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85501.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85501.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85501.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85501.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009510320.1","properties":[{"key":"NucleotideSequenceId","value":"NC_039137.1"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT6","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"37622619","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4541","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"InterPro","id":"IPR050269","properties":[{"key":"EntryName","value":"ComplexI_Subunit6"}]},{"database":"PANTHER","id":"PTHR11435","properties":[{"key":"EntryName","value":"NADH UBIQUINONE OXIDOREDUCTASE SUBUNIT ND6"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11435:SF1","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNYISFSQFYYCWGFWGGIKSSPYYAALGSVGGFGVGLYFGMFDLFGGMQQYSYSAALIADPYPEAWGIWPVLGRVLFFGLLVMIWGFMFGDWEWGYNMGWGLMPMPASGNIYCGVADELHNLSYLRGDFCGVAFLYGLGGMMLIICGWGLLITLFSVLELVRGQSRGALRAI","length":173,"molWeight":19242,"crc64":"E1903BABF032F8DB","md5":"69E56CF6A4941A47D51458812FB8B891"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":3},"uniParcId":"UPI000DF5E578"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT7","uniProtkbId":"A0A347ZJT7_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2018-11-07","entryVersion":34,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85502.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021008"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"value":"NADH-ubiquinone oxidoreductase chain 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85502.1"}],"value":"ND2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007012"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"value":"Belongs to the complex I subunit 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Transmembrane","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Transmembrane","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Transmembrane","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Transmembrane","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Transmembrane","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Transmembrane","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Transmembrane","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Transmembrane","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Transmembrane","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}]},{"type":"Domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]},{"type":"Domain","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"NADH dehydrogenase subunit 2 C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF06444"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85502.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003403"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85502.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85502.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85502.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009510321.1","properties":[{"key":"NucleotideSequenceId","value":"NC_039137.1"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT7","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"37622633","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4536","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006120","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, NADH to ubiquinone"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR050175","properties":[{"key":"EntryName","value":"Complex_I_Subunit_2"}]},{"database":"InterPro","id":"IPR010933","properties":[{"key":"EntryName","value":"NADH_DH_su2_C"}]},{"database":"InterPro","id":"IPR003917","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_chain2"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"PANTHER","id":"PTHR46552","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46552:SF1","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06444","properties":[{"key":"EntryName","value":"NADH_dehy_S2_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01436","properties":[{"key":"EntryName","value":"NADHDHGNASE2"}]}],"sequence":{"value":"MTPYVSFVLFTSLGLGTTITFASSHWLLAWLGLEINTLAIIPLMAQRNHPRALEATTKYFLVQAMAATLMLFTVTSNAWMTGHWEVQESSQPILAMITFLALGLKIGIAPMHYWLPEVMQGVDLMTGMILATWQKLAPMAMMFQLAPEMNMPLLLTLAITSTLMGGWGGINQTQLRKILAYSSIANMGWMLVVLKYMPNLMVLSLVFYIVMTMSIFMMVKMAAVTKINMLSTAWAKSPTLSVMTLVVILSIASLPPLTGFTPKWFILKSLTQQELTIIPTLMALSTLMSLFFYLRLCYSVALTTSPNTNNTKTSWRLKSKQMMKPMAPFITLTVMAFPLSPLATALTMINGDPTL","length":355,"molWeight":39451,"crc64":"ACA19970FED68E45","md5":"6378E2E68AA0090AF5F6EC1181F6EE62"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":10,"Domain":2},"uniParcId":"UPI000DF63EDF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJT9","uniProtkbId":"A0A347ZJT9_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-11-07","entryVersion":27,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85504.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015946"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Cytochrome c oxidase subunit 2"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85504.1"}],"value":"COII"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Cu cation","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:23378"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Binds a copper A center."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094606"}],"value":"Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and COXFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007866"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"value":"Belongs to the cytochrome c oxidase subunit 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit II transmembrane region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50999"}]},{"type":"Domain","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit II copper A binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50857"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85504.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000457"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85504.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85504.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85504.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A347ZJT9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005507","properties":[{"key":"GoTerm","value":"F:copper ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd13912","properties":[{"key":"EntryName","value":"CcO_II_C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.90:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.420:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.90","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.420","properties":[{"key":"EntryName","value":"Cupredoxins - blue copper proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR045187","properties":[{"key":"EntryName","value":"CcO_II"}]},{"database":"InterPro","id":"IPR002429","properties":[{"key":"EntryName","value":"CcO_II-like_C"}]},{"database":"InterPro","id":"IPR034210","properties":[{"key":"EntryName","value":"CcO_II_C"}]},{"database":"InterPro","id":"IPR001505","properties":[{"key":"EntryName","value":"Copper_CuA"}]},{"database":"InterPro","id":"IPR008972","properties":[{"key":"EntryName","value":"Cupredoxin"}]},{"database":"InterPro","id":"IPR014222","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2"}]},{"database":"InterPro","id":"IPR011759","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2_TM_dom"}]},{"database":"InterPro","id":"IPR036257","properties":[{"key":"EntryName","value":"Cyt_c_oxidase_su2_TM_sf"}]},{"database":"NCBIfam","id":"TIGR02866","properties":[{"key":"EntryName","value":"CoxB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22888:SF9","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22888","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE, SUBUNIT II"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00116","properties":[{"key":"EntryName","value":"COX2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02790","properties":[{"key":"EntryName","value":"COX2_TM"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01166","properties":[{"key":"EntryName","value":"CYCOXIDASEII"}]},{"database":"SUPFAM","id":"SSF49503","properties":[{"key":"EntryName","value":"Cupredoxins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81464","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit II-like, transmembrane region"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00078","properties":[{"key":"EntryName","value":"COX2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50857","properties":[{"key":"EntryName","value":"COX2_CUA"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50999","properties":[{"key":"EntryName","value":"COX2_TM"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALPSQTGFQDAASPIMEELIHFHDHALMIVLLISTFVAYIMIAMTTTTMFDLYTLDSQEIEIVWTILPAAILILIALPSLRILYLMDEINDPHLTIKTIGHQWYWSYEYSEYENLEFDSYLIPTQDLTPGQFRLLETDHRVVIPVKSPIRLMITAEDVLHSWTVPALGVKMDAVPGRLNQTALSAFRPGIYYGQCSEICGANHSFMPIVIEAVPLQNFEAWSSAMTEYLL","length":231,"molWeight":26257,"crc64":"E30CA772E8866BBA","md5":"32B3003B3A9FF34F7EB31DB79B033651"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":2,"Domain":2},"uniParcId":"UPI000DF601F3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJU0","uniProtkbId":"A0A347ZJU0_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-11-07","entryVersion":28,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85505.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016612"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"NADH-ubiquinone oxidoreductase chain 4L"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85505.1"}],"value":"ND4L"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043911"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048769"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:29092"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048769"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010519"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"value":"Belongs to the complex I subunit 4L family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}]},{"type":"Transmembrane","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}]},{"type":"Transmembrane","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85505.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004419"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85505.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85505.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85505.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"YP_009510324.1","properties":[{"key":"NucleotideSequenceId","value":"NC_039137.1"}]},{"database":"AlphaFoldDB","id":"A0A347ZJU0","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"37622641","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"4539","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0030964","properties":[{"key":"GoTerm","value":"C:NADH dehydrogenase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"1.10.287.3510","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001133","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase_chain4L/K"}]},{"database":"InterPro","id":"IPR039428","properties":[{"key":"EntryName","value":"NUOK/Mnh_C1-like"}]},{"database":"PANTHER","id":"PTHR11434:SF0","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11434","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00420","properties":[{"key":"EntryName","value":"Oxidored_q2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLSLHLGIPLTFILAILGLALHRKYLLSALLCLEAMMLTLYLTAAINPLQTQAAMQSSTPIMILAFSACEATVGLALLVATSRTHGTTLLKMLNMLQC","length":98,"molWeight":10529,"crc64":"2AABE5682E315390","md5":"75A0434EDF8F2C02C0D80B7F970475FD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":3},"uniParcId":"UPI000DF5EEFA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJU1","uniProtkbId":"A0A347ZJU1_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-11-07","entryVersion":31,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85506.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021006"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"NADH-ubiquinone oxidoreductase chain 4"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012944"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"7.1.1.2"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85506.1"}],"value":"ND4"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29091"},{"database":"Rhea","id":"RHEA-COMP:9565"},{"database":"Rhea","id":"RHEA-COMP:9566"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16389"},{"database":"ChEBI","id":"CHEBI:17976"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"7.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049551"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Mitochondrion membrane","id":"SL-0171"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004225"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009025"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"value":"Belongs to the complex I subunit 4 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Transmembrane","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"NADH:ubiquinone oxidoreductase chain 4 N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01059"}]},{"type":"Domain","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"NADH:quinone oxidoreductase/Mrp antiporter transmembrane","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00361"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85506.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU003297"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85506.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85506.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85506.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A347ZJU1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031966","properties":[{"key":"GoTerm","value":"C:mitochondrial membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0008137","properties":[{"key":"GoTerm","value":"F:NADH dehydrogenase (ubiquinone) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0048039","properties":[{"key":"GoTerm","value":"F:ubiquinone binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042773","properties":[{"key":"GoTerm","value":"P:ATP synthesis coupled electron transport"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR000260","properties":[{"key":"EntryName","value":"NADH4_N"}]},{"database":"InterPro","id":"IPR010227","properties":[{"key":"EntryName","value":"NADH_Q_OxRdtase_chainM/4"}]},{"database":"InterPro","id":"IPR003918","properties":[{"key":"EntryName","value":"NADH_UbQ_OxRdtase"}]},{"database":"InterPro","id":"IPR001750","properties":[{"key":"EntryName","value":"ND/Mrp_TM"}]},{"database":"NCBIfam","id":"TIGR01972","properties":[{"key":"EntryName","value":"NDH_I_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43507","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43507:SF20","properties":[{"key":"EntryName","value":"NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01059","properties":[{"key":"EntryName","value":"Oxidored_q5_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00361","properties":[{"key":"EntryName","value":"Proton_antipo_M"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01437","properties":[{"key":"EntryName","value":"NUOXDRDTASE4"}]}],"sequence":{"value":"MLKILIPTMMLIPTIWWADKKWVWSMILCQSLGIACVSLMWFKWETETGWATMSPHMATDPLSTPLLILSSWLLPLMILASQNHMNPEPPKRQKAYISLLVSLQLSLIMAFGATEIIMFYIMFETTLIPTLIIITRWGTQKERLHAGIYFLFYTMAGSLPLLVALMILQKDLGTLSMLMMSYTKPLITLTWSTQLWWAACLIAFLVKMPLYGMHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMIRILIIFSAPTKDLVYPFIIMALWGIIMTGTICLRQTDLKALIAYSSVSHMGLVTAGILTQTPWGLSGAMILMISHGLTSSALFCLANFNYERTRSRVLLLTRGLQIILPLMTAWWFIANLANMALPPLPNLMAEIMIITSMFNWSHWTLSTTGMGMLVTTGYSMYMFLATQRGPTPNHIINLTPTHTREHLLMAMHLIPILLLMLKPELIWGWHMCKYSLNKTLDCDS","length":473,"molWeight":53477,"crc64":"DDABE36DDF8EF65A","md5":"8F1E494D03E04AAB0ACF05EDEB74E75F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":13,"Domain":2},"uniParcId":"UPI000DF61840"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A347ZJU2","uniProtkbId":"A0A347ZJU2_9TELE","entryAudit":{"firstPublicDate":"2018-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-11-07","entryVersion":27,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Neocyema erythrosoma","taxonId":2024705,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85507.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Anguilliformes","Cyematidae","Neocyema"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Cytochrome b"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85507.1"}],"value":"cyt b"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002566"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"heme b","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:60344"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Binds 2 heme groups non-covalently."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"value":"Binds 2 heme groups non-covalently."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011660"}],"value":"The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061233"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Transmembrane","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16389"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-1"}],"ligand":{"name":"a ubiquinone","id":"ChEBI:CHEBI:16389"}}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85507.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR038885-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362117"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6RD01UP8EHNOM","citationType":"submission","authors":["Poulsen JY."],"publicationDate":"AUG-2017","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85507.1"}]},{"referenceNumber":2,"citation":{"id":"30044814","citationType":"journal article","authors":["Poulsen J.Y.","Miller M.J.","Sado T.","Hanel R.","Tsukamoto T.","Miya M."],"citationCrossReferences":[{"database":"PubMed","id":"30044814"},{"database":"DOI","id":"10.1371/journal.pone.0199982"}],"title":"Resolving deep-sea pelagic saccopharyngiform eel mysteries: Identification of Neocyema and Monognathidae leptocephali and establishment of a new fish family \"Neocyematidae\" based on larvae, adults and mitogenomic gene orders.","publicationDate":"2018","journal":"PLoS ONE","firstPage":"e0199982","lastPage":"e0199982","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BBA85507.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP018345","properties":[{"key":"ProteinId","value":"BBA85507.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A347ZJU2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045275","properties":[{"key":"GoTerm","value":"C:respiratory chain complex III"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00290","properties":[{"key":"EntryName","value":"cytochrome_b_C"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.810.10:FF:000002","properties":[{"key":"EntryName","value":"Cytochrome b"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR036150","properties":[{"key":"EntryName","value":"Cyt_b/b6_C_sf"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR030689","properties":[{"key":"EntryName","value":"Cytochrome_b"}]},{"database":"InterPro","id":"IPR048260","properties":[{"key":"EntryName","value":"Cytochrome_b_C_euk/bac"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00032","properties":[{"key":"EntryName","value":"Cytochrom_B_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038885","properties":[{"key":"EntryName","value":"COB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81648","properties":[{"key":"EntryName","value":"a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTKLRKSYPMLSTTNDSLVDLPAPPNLSAWWNFGSLIGLALILQIITGIFLGMNYASDISTAFSSVVHAHREVEMGWMIRHMHMNGASLLFVLLYLHAARGLYYGSYLFMETWSIGVILFLLMMTTAFVGYVLPWGQMSFWGATVITNLTSAVPYMGDSVVQWLWGGYAVDNATLNRFFTFHFLLPFIILGLTTIHLMFLHETGSNNPIGLNSNSDKIPFHPYFSYKDLVGFFIILMILVNIALFFPNLLGDPENFTQANSMTTPAHIKPEWYFLFAYAILRAVPNKMGGVMALMSSILILLVTPILHTSKQRGLMFRPPSKWLFWVLVIIVFMLTWVGGMPVEQPFIVIGQVTSVLYFSMFLIIHPLTGWLENKMLMKK","length":380,"molWeight":43082,"crc64":"0CE814AF2DA5DD04","md5":"BCAD484C1B4254B165E63CBD79E5AF6F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":8,"Domain":2,"Binding site":5},"uniParcId":"UPI000DF60823"}}]}