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Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Together with LhpH, is involved in a trans-3-hydroxy-L-proline (t3LHyp) degradation pathway to L-proline, which allows A.brasilense to grow on t3LHyp as a sole carbon source. Also appears to be involved in D-proline and D-lysine metabolism. 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NAD(+)."}]}},"phDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24649405"}],"value":"Optimum pH is 6.5 for Pyr2C reduction and 10.5 for L-proline oxidation."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24649405"}],"value":"Amino-acid degradation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24649405"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24649405"}],"value":"Induced by trans-3-hydroxy-L-proline (T3LHyp), D-proline and D-lysine, but not by trans-4-hydroxy-L-proline (T4LHyp) and by cis-4-hydroxy-D-proline (C4DHyp)"}],"commentType":"INDUCTION"},{"texts":[{"value":"Disruption of this gene leads to loss of growth on T3LHyp, D-proline and D-lysine as a sole carbon source, indicating that this gene has dual metabolic functions as a reductase for Pyr2C and Pip2C in these pathways. 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