{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q06VT1","uniProtkbId":"Q06VT1_9BACT","entryAudit":{"firstPublicDate":"2006-10-31","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-31","entryVersion":38,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61436.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}],"value":"Nickel/cobalt efflux system"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61436.1"}],"value":"ncrC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002510"}],"value":"Efflux system for nickel and cobalt"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}],"value":"Belongs to the NiCoT transporter (TC 2.A.52) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}]},{"type":"Transmembrane","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}]},{"type":"Transmembrane","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}]},{"type":"Transmembrane","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}]},{"type":"Transmembrane","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}]},{"type":"Transmembrane","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023285"}],"id":"KW-0170","category":"Ligand","name":"Cobalt"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022426"}],"id":"KW-0171","category":"Biological process","name":"Cobalt transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022596"}],"id":"KW-0533","category":"Ligand","name":"Nickel"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023112"}],"id":"KW-0921","category":"Biological process","name":"Nickel transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU362101"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"17293508","citationType":"journal article","authors":["Tian J.","Wu N.","Li J.","Liu Y.","Guo J.","Yao B.","Fan Y."],"citationCrossReferences":[{"database":"PubMed","id":"17293508"},{"database":"DOI","id":"10.1128/AEM.00207-07"}],"title":"Nickel-resistant determinant from Leptospirillum ferriphilum.","publicationDate":"2007","journal":"Appl. Environ. Microbiol.","firstPage":"2364","lastPage":"2368","volume":"73"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61436.1"}],"value":"UBK03","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61436.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ517331","properties":[{"key":"ProteinId","value":"ABF61436.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q06VT1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0046583","properties":[{"key":"GoTerm","value":"F:monoatomic cation efflux transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0015099","properties":[{"key":"GoTerm","value":"F:nickel cation transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0032025","properties":[{"key":"GoTerm","value":"P:response to cobalt ion"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0010045","properties":[{"key":"GoTerm","value":"P:response to nickel cation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"InterPro","id":"IPR011541","properties":[{"key":"EntryName","value":"Ni/Co_transpt_high_affinity"}]},{"database":"InterPro","id":"IPR051224","properties":[{"key":"EntryName","value":"NiCoT_RcnA"}]},{"database":"NCBIfam","id":"NF007454","properties":[{"key":"EntryName","value":"PRK10019.1"},{"key":"MatchStatus","value":"2"}]},{"database":"PANTHER","id":"PTHR40659","properties":[{"key":"EntryName","value":"NICKEL/COBALT EFFLUX SYSTEM RCNA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR40659:SF1","properties":[{"key":"EntryName","value":"NICKEL_COBALT EFFLUX SYSTEM RCNA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03824","properties":[{"key":"EntryName","value":"NicO"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MTDFSTLLQQGVANAWLFIPSAILLGALHGLEPGHSKTMMAAFIVAIRGTVKQAVLLGLAATISHTSVVWLIAFGGMYISQKFTAESAEPWFQLISAVIILGTAAWMFWRTWRGEKLWKMEQEEEHSHGHHDHDETRIIDTGHGSVELSIFEEGQPPHWRLRSLSGKKWEARDISLVTNRGPGTFSQVFDFVEKDGFMESALAIPEPHSFDVRLSLGHRGHVHDYDVEFREHEHDHDHSSLEGLDVNSREYQDAHEKAHANDIKKRFANRSVTTGQIILFGLTGGLIPCPAAITVLLLCIQVKEFTLGAALVLCFSIGLAITLVSVGAAAAFSVRQATKRWSGLDTLARRAPYFSSVLIALVGIYMGYHGWIGVTS","length":376,"molWeight":41605,"crc64":"A90AD071A30CE573","md5":"78D1DAD7ADAA37DB74C5B13B6C88FC7D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":6},"uniParcId":"UPI0000E2D037"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q06VT2","uniProtkbId":"Q06VT2_9BACT","entryAudit":{"firstPublicDate":"2006-10-31","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-31","entryVersion":36,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61435.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00039938"}],"value":"Copper-sensing transcriptional repressor CsoR"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041544"}],"value":"Copper-sensitive operon repressor"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61435.1"}],"value":"ncrB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005260"}],"value":"Belongs to the FrmR/RcnR family"}],"commentType":"SIMILARITY"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"17293508","citationType":"journal article","authors":["Tian J.","Wu N.","Li J.","Liu Y.","Guo J.","Yao B.","Fan Y."],"citationCrossReferences":[{"database":"PubMed","id":"17293508"},{"database":"DOI","id":"10.1128/AEM.00207-07"}],"title":"Nickel-resistant determinant from Leptospirillum ferriphilum.","publicationDate":"2007","journal":"Appl. Environ. Microbiol.","firstPage":"2364","lastPage":"2368","volume":"73"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61435.1"}],"value":"UBK03","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61435.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ517331","properties":[{"key":"ProteinId","value":"ABF61435.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q06VT2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q06VT2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd10154","properties":[{"key":"EntryName","value":"NreA-like_DUF156"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1000","properties":[{"key":"EntryName","value":"Metal-sensitive repressor, helix protomer"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003735","properties":[{"key":"EntryName","value":"Metal_Tscrpt_repr"}]},{"database":"InterPro","id":"IPR038390","properties":[{"key":"EntryName","value":"Metal_Tscrpt_repr_sf"}]},{"database":"PANTHER","id":"PTHR33677:SF4","properties":[{"key":"EntryName","value":"COPPER-SENSING TRANSCRIPTIONAL REPRESSOR CSOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33677","properties":[{"key":"EntryName","value":"TRANSCRIPTIONAL REPRESSOR FRMR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02583","properties":[{"key":"EntryName","value":"Trns_repr_metal"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTVHASHPDIIKRLKRAAGHLKSTIQMLEDEKACLDIAQQLHAVEKAITNAKRTLIHDHLDHCLEDALHADHTESDKTLSEFKEITKYL","length":89,"molWeight":10133,"crc64":"62D3FC546C28CC83","md5":"61F718C53AB42D24C936EE647718AC87"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"uniParcId":"UPI0000E2D036"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q2LMN3","uniProtkbId":"Q2LMN3_9BACT","entryAudit":{"firstPublicDate":"2006-02-21","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-02-21","entryVersion":38,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85171.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"value":"Arsenical pump membrane protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85171.1"}],"value":"arsB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"value":"Involved in arsenical resistance. Thought to form the channel of an arsenite pump"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"value":"Belongs to the ArsB family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}]},{"type":"Transmembrane","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}]},{"type":"Transmembrane","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}]},{"type":"Transmembrane","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}]},{"type":"Transmembrane","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}]},{"type":"Transmembrane","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}]},{"type":"Transmembrane","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}]},{"type":"Transmembrane","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"id":"KW-0059","category":"Biological process","name":"Arsenical resistance"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004993"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"16517682","citationType":"journal article","authors":["Tuffin I.M.","Hector S.B.","Deane S.M.","Rawlings D.E."],"citationCrossReferences":[{"database":"PubMed","id":"16517682"},{"database":"DOI","id":"10.1128/AEM.72.3.2247-2253.2006"}],"title":"Resistance determinants of a highly arsenic-resistant strain of Leptospirillum ferriphilum isolated from a commercial biooxidation tank.","publicationDate":"2006","journal":"Appl. Environ. Microbiol.","firstPage":"2247","lastPage":"2253","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85171.1"}],"value":"Fairview","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85171.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ057986","properties":[{"key":"ProteinId","value":"AAY85171.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q2LMN3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0042960","properties":[{"key":"GoTerm","value":"F:antimonite secondary active transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0008490","properties":[{"key":"GoTerm","value":"F:arsenite secondary active transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01118","properties":[{"key":"EntryName","value":"ArsB_permease"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000802","properties":[{"key":"EntryName","value":"Arsenical_pump_ArsB"}]},{"database":"NCBIfam","id":"TIGR00935","properties":[{"key":"EntryName","value":"2a45"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF011980","properties":[{"key":"EntryName","value":"arsB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43302","properties":[{"key":"EntryName","value":"TRANSPORTER ARSB-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43302:SF5","properties":[{"key":"EntryName","value":"TRANSPORTER ARSB-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02040","properties":[{"key":"EntryName","value":"ArsB"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00758","properties":[{"key":"EntryName","value":"ARSENICPUMP"}]}],"sequence":{"value":"MIAALPIFLATIVLVIWQPRGLGIGWSATLGAVVALLSGVVHFGDIPVVWQIVWNATATFIAIIIISLLLDEAGFFEWAALHVARWGGGKGRLLFALIILLGAAVAALFANDGAALILTPIVMAMLLALGFSPAATLAFVMAAGFIADAASLPLVVSNLVNIVSADFFNIGFNDYAAVMIPVNIVAIIASLAVLSIYFRRSIPAHYDVNQLKQPNEAIRDVATFRFGWVVLALLLVGFFGLEPLGVPVSAVAAAGALLLLAVAARGHVISTRKVIREAPWQIVVFSLGMYLVVYGLRNQGLAEHIARLLDYFAQGGVWGAAFGTGFLTALLSSAMNNMPTVLVGALSIDATSATGVVKDTMIYANVIGSDLGPKITPIGSLATLLWLHVLARKGMTITWGYYFKVGVVLTVPVLAATLAALALRLSLT","length":428,"molWeight":45056,"crc64":"B0DC9AA967FCF6B5","md5":"397034B5F298E1401D0376DA8713E591"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":8},"uniParcId":"UPI0000683F63"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q2LMN5","uniProtkbId":"Q2LMN5_9BACT","entryAudit":{"firstPublicDate":"2006-02-21","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2006-02-21","entryVersion":68,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85169.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00066752"}],"value":"arsenite-transporting ATPase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00066752"}],"value":"7.3.2.7"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85169.1"}],"value":"arsA"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"arsenite(in) + ATP + H2O = arsenite(out) + ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11348"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29242"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"7.3.2.7","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052296"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011040"}],"value":"Belongs to the arsA ATPase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"AAA+ ATPase","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00382"}]},{"type":"Domain","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"AAA+ ATPase","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00382"}]}],"references":[{"referenceNumber":1,"citation":{"id":"16517682","citationType":"journal article","authors":["Tuffin I.M.","Hector S.B.","Deane S.M.","Rawlings D.E."],"citationCrossReferences":[{"database":"PubMed","id":"16517682"},{"database":"DOI","id":"10.1128/AEM.72.3.2247-2253.2006"}],"title":"Resistance determinants of a highly arsenic-resistant strain of Leptospirillum ferriphilum isolated from a commercial biooxidation tank.","publicationDate":"2006","journal":"Appl. Environ. Microbiol.","firstPage":"2247","lastPage":"2253","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85169.1"}],"value":"Fairview","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85169.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ057986","properties":[{"key":"ProteinId","value":"AAY85169.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q2LMN5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015446","properties":[{"key":"GoTerm","value":"F:ATPase-coupled arsenite transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"CDD","id":"cd02035","properties":[{"key":"EntryName","value":"ArsA"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR027541","properties":[{"key":"EntryName","value":"Ars_ATPase"}]},{"database":"InterPro","id":"IPR025723","properties":[{"key":"EntryName","value":"ArsA/GET3_ATPase-like"}]},{"database":"InterPro","id":"IPR016300","properties":[{"key":"EntryName","value":"ATPase_ArsA/GET3"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"NCBIfam","id":"TIGR04291","properties":[{"key":"EntryName","value":"arsen_driv_ArsA"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR00345","properties":[{"key":"EntryName","value":"GET3_arsA_TRC40"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10803","properties":[{"key":"EntryName","value":"ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10803:SF3","properties":[{"key":"EntryName","value":"ATPASE GET3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02374","properties":[{"key":"EntryName","value":"ArsA_ATPase"},{"key":"MatchStatus","value":"2"}]},{"database":"PIRSF","id":"PIRSF001327","properties":[{"key":"EntryName","value":"Arsenical_pump-driving_ATPase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MEKMMMIFLQLPPRFLFFTGKGGVGKTSIACATAIQLAEAGKRVLLVSTDPASNVGQVFGVDIGNRVTPIPAVPRLSALEIDPEAAASAYRERLVGPVRGVLPDDVVKGIEESLSGACTTEIAAFDEFTALLTNVALTADYEHIIFDTAPTGHTIRLLQLPGAWSGFLEAGKGDASCLGPLAGLEKQRTQYKAAVEALADPLQTRLVLVARAQQATLREVARTHEELAAIGLKQQHLVINGILPHIEAATDPLAAAIHEREQTALKNIPATLTALPCDHVELKPFNLVGLDALRQLLTDLPPQAPVAVDSPIELDEPGVADLIDGIAADGHGLVMLMGKGGVGKTTLAAAIAVELAHRGLPVHLTTSDPAAHLTDTLDSSLDNLTVSRIDPHAETERYRQHVLETKGAQLDAEGRALLEEDLRSPCTEEIAVFQAFSRIIREAGKKFVVMDTAPTGHTLLLLDATGAYHREVTRQMGKTGMHFTTPMMQLQDPKQTKVLIVTLAETTPVLEAANLQADLRRAGIEPWAWIINTSVAAASAKSPLLRQRAANELREISAVANQHADRYAVVPLLKEEPIGADRLRALIHPQT","length":591,"molWeight":63367,"crc64":"B3DBCD0A36385941","md5":"655C97B4AA2EF4A02BE5E7DECB790E6F"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2},"uniParcId":"UPI0000683F61"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q06VT0","uniProtkbId":"Q06VT0_9BACT","entryAudit":{"firstPublicDate":"2006-10-31","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2006-10-31","entryVersion":41,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61437.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61437.1"}],"value":"NcrY"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61437.1"}],"value":"ncrY"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5004165410"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"17293508","citationType":"journal article","authors":["Tian J.","Wu N.","Li J.","Liu Y.","Guo J.","Yao B.","Fan Y."],"citationCrossReferences":[{"database":"PubMed","id":"17293508"},{"database":"DOI","id":"10.1128/AEM.00207-07"}],"title":"Nickel-resistant determinant from Leptospirillum ferriphilum.","publicationDate":"2007","journal":"Appl. Environ. Microbiol.","firstPage":"2364","lastPage":"2368","volume":"73"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61437.1"}],"value":"UBK03","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61437.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ517331","properties":[{"key":"ProteinId","value":"ABF61437.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q06VT0","properties":[{"key":"Description","value":"-"}]},{"database":"Gene3D","id":"2.40.50.200","properties":[{"key":"EntryName","value":"Bacterial OB-fold"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036700","properties":[{"key":"EntryName","value":"BOBF_sf"}]},{"database":"InterPro","id":"IPR005220","properties":[{"key":"EntryName","value":"CarO-like"}]},{"database":"NCBIfam","id":"NF033674","properties":[{"key":"EntryName","value":"stress_OB_fold"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36571:SF2","properties":[{"key":"EntryName","value":"PERIPLASMIC PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36571","properties":[{"key":"EntryName","value":"PROTEIN YGIW"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04076","properties":[{"key":"EntryName","value":"BOF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF101756","properties":[{"key":"EntryName","value":"Hypothetical protein YgiW"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MESAMQKQYFSQFVTGVLLTSFIAIPALAAQGGFSAEKEPVVTEHMYAGHKVQQENSQSRIQIVSSMHEGAWITLEGNVVSQQQDEWYTFRDPTGTIKVRIPQKVWNGQHFDAQDLVRVSGPVSHENDGSILYVAVISKP","length":140,"molWeight":15593,"crc64":"D322C096A569FC40","md5":"8C3544AA6A0ED7032A5C0757EE3AAF39"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI0000E2D038"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q06VT3","uniProtkbId":"Q06VT3_9BACT","entryAudit":{"firstPublicDate":"2006-10-31","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-10-31","entryVersion":48,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61434.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61434.1"}],"value":"NcrA"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61434.1"}],"value":"ncrA"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004651"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":390,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]},{"type":"Region","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"17293508","citationType":"journal article","authors":["Tian J.","Wu N.","Li J.","Liu Y.","Guo J.","Yao B.","Fan Y."],"citationCrossReferences":[{"database":"PubMed","id":"17293508"},{"database":"DOI","id":"10.1128/AEM.00207-07"}],"title":"Nickel-resistant determinant from Leptospirillum ferriphilum.","publicationDate":"2007","journal":"Appl. Environ. Microbiol.","firstPage":"2364","lastPage":"2368","volume":"73"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61434.1"}],"value":"UBK03","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABF61434.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ517331","properties":[{"key":"ProteinId","value":"ABF61434.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q06VT3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0022857","properties":[{"key":"GoTerm","value":"F:transmembrane transporter activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd06173","properties":[{"key":"EntryName","value":"MFS_MefA_like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"PANTHER","id":"PTHR43266","properties":[{"key":"EntryName","value":"MACROLIDE-EFFLUX PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43266:SF2","properties":[{"key":"EntryName","value":"MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLNILSNRTYRHLFMAQVIALIGTGLATVALGLLAYDLAGDRAGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEREYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAVGFLASAALVVSVTLPKMKALTVKRSIYDKTTRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVLIWRPEHEVYAQVHSHKDPETNNESTHEHDFVIDDEHPSWPKKEK","length":432,"molWeight":46734,"crc64":"8291A16F97DA2BD0","md5":"7D280E6D9CA88CABCDB8D0B64F84DD35"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":12,"Domain":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000E2D035"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q2LMN2","uniProtkbId":"Q2LMN2_9BACT","entryAudit":{"firstPublicDate":"2006-02-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-02-21","entryVersion":30,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85172.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85172.1"}],"value":"Transposase-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85172.1"}],"value":"tnpA"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009402"}],"value":"Belongs to the transposase 7 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"DUF4158","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF13700"}]},{"type":"Domain","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":966,"modifier":"EXACT"}},"description":"Tn3 transposase DDE","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01526"}]},{"type":"Region","location":{"start":{"value":673,"modifier":"EXACT"},"end":{"value":702,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":674,"modifier":"EXACT"},"end":{"value":695,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022578"}],"id":"KW-0815","category":"Biological process","name":"Transposition"}],"references":[{"referenceNumber":1,"citation":{"id":"16517682","citationType":"journal article","authors":["Tuffin I.M.","Hector S.B.","Deane S.M.","Rawlings D.E."],"citationCrossReferences":[{"database":"PubMed","id":"16517682"},{"database":"DOI","id":"10.1128/AEM.72.3.2247-2253.2006"}],"title":"Resistance determinants of a highly arsenic-resistant strain of Leptospirillum ferriphilum isolated from a commercial biooxidation tank.","publicationDate":"2006","journal":"Appl. Environ. Microbiol.","firstPage":"2247","lastPage":"2253","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85172.1"}],"value":"Fairview","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85172.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ057986","properties":[{"key":"ProteinId","value":"AAY85172.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q2LMN2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004803","properties":[{"key":"GoTerm","value":"F:transposase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006313","properties":[{"key":"GoTerm","value":"P:DNA transposition"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR025296","properties":[{"key":"EntryName","value":"DUF4158"}]},{"database":"InterPro","id":"IPR047653","properties":[{"key":"EntryName","value":"Tn3-like_transpos"}]},{"database":"InterPro","id":"IPR002513","properties":[{"key":"EntryName","value":"Tn3_Tnp_DDE_dom"}]},{"database":"NCBIfam","id":"NF033527","properties":[{"key":"EntryName","value":"transpos_Tn3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01526","properties":[{"key":"EntryName","value":"DDE_Tnp_Tn3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13700","properties":[{"key":"EntryName","value":"DUF4158"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPRRSILSAAERDNLLALPDAKEELIRHYTFSDSDLSIIRQRRGPANRLGFAVQLCYLRFPGVILGADEPPFPPLLKLVADQLKIGIESWGEYGQRGQTRREHLVELQTVFGFQPFTMSHYRQAVQLLTELAMQTDKGIVLASALIEHLRRQSVILPALNAVERASAEAITRANWRIYDALAEPLSDVHRRRLDDLLKRRDNGKTTWLAWLRQSPAKPNSRHMLEHIERLKAWQALDLPSGVERSVHQNRLLKIAREGGQMTPADLAKFEAQRRYATLVALAIEGMATVTDEIIDLHDRILGKLFNAAKNKHQQQFQASGKAINAKVRLYGRIGQALIDAKQSGRDPFAAIEAVMSWDAFAESVTEAQKLAQPDDFDFLHRIGESYATLRGYAPEFLAVLKLRAAPAAKNVLDAIEVLRGMNTDNARKVPADAPTGFIKPRWQKLVMTDTGIDRRYYELCALSELKNSLRSGDIWVQGSRQFKDFEDYLVPPAKFASLKQSSELPLAVATDCDQYLSERLELLEAQLATVNRMAAANDLPDAIITESGLKITPLDAAVPDTAQALIDQTAMILPHVKITELLLEVDEWTGFTRHFTHLKSGDLAKDKNLLLTTILADAINLGLTKMAESCPGTTYAKLAWLQAWNTRDETYSTALAELVNAQFRHPFAGHWGDGTTSSSDGQNFRTGSKAESTGHINPKYGSSPGRTFYTHISDQYAPFHTKVVNVGVRDSTYVLDGLLYHESDLRIEEHYTDTAGFTDHVFALMHLLGFRFAPRIRDLGDTKLYIPKGETAYDALKPMIGGTLNIKHVRAHWDEILRLATSIKQGTVTASLMLRKLGSYPRQNGLAVALRELGRIERTLFILDWLQSVELRRRVHAGLNKGEARNALARAVFFNRLGEIRDRSFEQQRYRASGLNLVTAAIVLWNTVYLERAANALRDHGKPVDDSLLQYLSPLGWEHINLTGDYLWRSSAKIGAGKFRPLRPLQPA","length":988,"molWeight":110856,"crc64":"4CD607BA57C6B087","md5":"FECAFFC7B5F6D0B011BAE3C73BBED346"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Region":1,"Compositional bias":1},"uniParcId":"UPI0000683F64"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q2LMN4","uniProtkbId":"Q2LMN4_9BACT","entryAudit":{"firstPublicDate":"2006-02-21","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2006-02-21","entryVersion":37,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85170.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85170.1"}],"value":"CBS domain-like protein"}}]},"features":[{"type":"Domain","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"CBS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51371"}]},{"type":"Domain","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"CBS","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51371"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023122"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00703"}],"id":"KW-0129","category":"Domain","name":"CBS domain"}],"references":[{"referenceNumber":1,"citation":{"id":"16517682","citationType":"journal article","authors":["Tuffin I.M.","Hector S.B.","Deane S.M.","Rawlings D.E."],"citationCrossReferences":[{"database":"PubMed","id":"16517682"},{"database":"DOI","id":"10.1128/AEM.72.3.2247-2253.2006"}],"title":"Resistance determinants of a highly arsenic-resistant strain of Leptospirillum ferriphilum isolated from a commercial biooxidation tank.","publicationDate":"2006","journal":"Appl. Environ. Microbiol.","firstPage":"2247","lastPage":"2253","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85170.1"}],"value":"Fairview","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85170.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ057986","properties":[{"key":"ProteinId","value":"AAY85170.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q2LMN4","properties":[{"key":"Description","value":"-"}]},{"database":"CDD","id":"cd04586","properties":[{"key":"EntryName","value":"CBS_pair_BON_assoc"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.580.10","properties":[{"key":"EntryName","value":"CBS-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000644","properties":[{"key":"EntryName","value":"CBS_dom"}]},{"database":"InterPro","id":"IPR046342","properties":[{"key":"EntryName","value":"CBS_dom_sf"}]},{"database":"InterPro","id":"IPR051257","properties":[{"key":"EntryName","value":"Diverse_CBS-Domain"}]},{"database":"PANTHER","id":"PTHR43080","properties":[{"key":"EntryName","value":"CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43080:SF29","properties":[{"key":"EntryName","value":"OS02G0818000 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00571","properties":[{"key":"EntryName","value":"CBS"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00116","properties":[{"key":"EntryName","value":"CBS"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF54631","properties":[{"key":"EntryName","value":"CBS-domain pair"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51371","properties":[{"key":"EntryName","value":"CBS"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MLIRNFMTPDPVTIQPETPVEDIARLLLAHRINGVPVVDGAGRLIGVVTAEDLIHRGADERLEPRESIWKENFWVSFLGPKGTQRDKAEGRTAAEVMTTEVHSVTPAMHPSVAARLMVDHHLTALPVVDDGKVIGVISRIDLLSLLKELENPLKREN","length":157,"molWeight":17376,"crc64":"2096B1E88E864470","md5":"CB8FDB3E1DA13A8DEFA7FFA17723D3C2"},"extraAttributes":{"countByFeatureType":{"Domain":2},"uniParcId":"UPI0000683F62"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q2LMN6","uniProtkbId":"Q2LMN6_9BACT","entryAudit":{"firstPublicDate":"2006-02-21","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-02-21","entryVersion":32,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85168.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85168.1"}],"value":"Trans-acting repressor-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85168.1"}],"value":"arsD"}}],"references":[{"referenceNumber":1,"citation":{"id":"16517682","citationType":"journal article","authors":["Tuffin I.M.","Hector S.B.","Deane S.M.","Rawlings D.E."],"citationCrossReferences":[{"database":"PubMed","id":"16517682"},{"database":"DOI","id":"10.1128/AEM.72.3.2247-2253.2006"}],"title":"Resistance determinants of a highly arsenic-resistant strain of Leptospirillum ferriphilum isolated from a commercial biooxidation tank.","publicationDate":"2006","journal":"Appl. Environ. Microbiol.","firstPage":"2247","lastPage":"2253","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85168.1"}],"value":"Fairview","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85168.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ057986","properties":[{"key":"ProteinId","value":"AAY85168.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q2LMN6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046685","properties":[{"key":"GoTerm","value":"P:response to arsenic-containing substance"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.30.10","properties":[{"key":"EntryName","value":"Glutaredoxin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010712","properties":[{"key":"EntryName","value":"Arsenical-R_ArsD"}]},{"database":"InterPro","id":"IPR036249","properties":[{"key":"EntryName","value":"Thioredoxin-like_sf"}]},{"database":"NCBIfam","id":"NF033727","properties":[{"key":"EntryName","value":"chaperon_ArsD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06953","properties":[{"key":"EntryName","value":"ArsD"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKKIEVFDPSLCCSTGVCGVDVDQALVTFAADVDWAKQNGAHIERYNLAQQPQMFADNATVKGFLQRSGQDALPLILVDGEVALAGRYPKRAELALWIGIDQPADAAKPTTGGCCSGPRGCC","length":122,"molWeight":12957,"crc64":"1EA7741616796A7A","md5":"6477F72DAAE6D92D0ADEDD7CB314C2E2"},"extraAttributes":{"uniParcId":"UPI0000683F60"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q2LMN7","uniProtkbId":"Q2LMN7_9BACT","entryAudit":{"firstPublicDate":"2006-02-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-02-21","entryVersion":47,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85167.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85167.1"}],"value":"Arsenate reductase-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85167.1"}],"value":"arsC"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"Phosphotyrosine protein phosphatase I","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00226"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022849"}],"id":"KW-0059","category":"Biological process","name":"Arsenical resistance"}],"references":[{"referenceNumber":1,"citation":{"id":"16517682","citationType":"journal article","authors":["Tuffin I.M.","Hector S.B.","Deane S.M.","Rawlings D.E."],"citationCrossReferences":[{"database":"PubMed","id":"16517682"},{"database":"DOI","id":"10.1128/AEM.72.3.2247-2253.2006"}],"title":"Resistance determinants of a highly arsenic-resistant strain of Leptospirillum ferriphilum isolated from a commercial biooxidation tank.","publicationDate":"2006","journal":"Appl. Environ. Microbiol.","firstPage":"2247","lastPage":"2253","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85167.1"}],"value":"Fairview","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85167.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ057986","properties":[{"key":"ProteinId","value":"AAY85167.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q2LMN7","properties":[{"key":"Description","value":"-"}]},{"database":"CDD","id":"cd16345","properties":[{"key":"EntryName","value":"LMWP_ArsC"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.2300","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023485","properties":[{"key":"EntryName","value":"Ptyr_pPase"}]},{"database":"InterPro","id":"IPR036196","properties":[{"key":"EntryName","value":"Ptyr_pPase_sf"}]},{"database":"PANTHER","id":"PTHR43428","properties":[{"key":"EntryName","value":"ARSENATE REDUCTASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43428:SF1","properties":[{"key":"EntryName","value":"ARSENATE REDUCTASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01451","properties":[{"key":"EntryName","value":"LMWPc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00226","properties":[{"key":"EntryName","value":"LMWPc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52788","properties":[{"key":"EntryName","value":"Phosphotyrosine protein phosphatases I"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNILFLCTGNSCRSILAEATFNHLAPTGWKAMSAGSQPTGTVHPRSLSLLTHEGIDTGGLHSKSWDNLPLAPDVVITVCANAAGETCPAYLGPVLRAHWGVDDPAHATGTEAEIEAAFPTAYRILRRRIEALLALPLAQLAHDRTRLKAELDRIGALSA","length":159,"molWeight":16927,"crc64":"029F041E833E1EB7","md5":"2A2BA3F064DE8AB560994731CBC5F402"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI0000683F5F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q2LMN8","uniProtkbId":"Q2LMN8_9BACT","entryAudit":{"firstPublicDate":"2006-02-21","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-02-21","entryVersion":69,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85166.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85166.1"}],"value":"Transcriptional regulator-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85166.1"}],"value":"arsR"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"HTH arsR-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50987"}]},{"type":"DNA binding","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"H-T-H motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00340"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00340"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00340"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00340"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"16517682","citationType":"journal article","authors":["Tuffin I.M.","Hector S.B.","Deane S.M.","Rawlings D.E."],"citationCrossReferences":[{"database":"PubMed","id":"16517682"},{"database":"DOI","id":"10.1128/AEM.72.3.2247-2253.2006"}],"title":"Resistance determinants of a highly arsenic-resistant strain of Leptospirillum ferriphilum isolated from a commercial biooxidation tank.","publicationDate":"2006","journal":"Appl. Environ. Microbiol.","firstPage":"2247","lastPage":"2253","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85166.1"}],"value":"Fairview","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85166.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ057986","properties":[{"key":"ProteinId","value":"AAY85166.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q2LMN8","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00090","properties":[{"key":"EntryName","value":"HTH_ARSR"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011991","properties":[{"key":"EntryName","value":"ArsR-like_HTH"}]},{"database":"InterPro","id":"IPR001845","properties":[{"key":"EntryName","value":"HTH_ArsR_DNA-bd_dom"}]},{"database":"InterPro","id":"IPR051011","properties":[{"key":"EntryName","value":"Metal_resp_trans_reg"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"NCBIfam","id":"NF033788","properties":[{"key":"EntryName","value":"HTH_metalloreg"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43132","properties":[{"key":"EntryName","value":"ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43132:SF2","properties":[{"key":"EntryName","value":"ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12840","properties":[{"key":"EntryName","value":"HTH_20"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00778","properties":[{"key":"EntryName","value":"HTHARSR"}]},{"database":"SMART","id":"SM00418","properties":[{"key":"EntryName","value":"HTH_ARSR"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50987","properties":[{"key":"EntryName","value":"HTH_ARSR_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEKQAATSIFESLSSGLRLDVFRLLVKKGPGGMVAGEIANALDIPPANLSFHLKALSQAHLVTVEQEGRFQRYRADIPLMLDLIAYLTEECCSGSPDQCLELRTASKCSEEFLPLLSPTPTKATT","length":125,"molWeight":13610,"crc64":"70704992F7E22502","md5":"D9389B82CB1407E3E29212ACDA118E41"},"extraAttributes":{"countByFeatureType":{"Domain":1,"DNA binding":1},"uniParcId":"UPI0000683F5E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q2LMN9","uniProtkbId":"Q2LMN9_9BACT","entryAudit":{"firstPublicDate":"2006-02-21","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2006-02-21","entryVersion":69,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Leptospirillum ferriphilum","taxonId":178606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85165.1"}],"lineage":["Bacteria","Pseudomonadati","Nitrospirota","Nitrospiria","Nitrospirales","Nitrospiraceae","Leptospirillum"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85165.1"}],"value":"Resolvase-like protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85165.1"}],"value":"tnpR"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009913"}],"value":"Belongs to the site-specific recombinase resolvase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Resolvase/invertase-type recombinase catalytic","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51736"}]},{"type":"Active site","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"O-(5'-phospho-DNA)-serine intermediate","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR606118-50"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01072"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022908"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01072"}],"id":"KW-0229","category":"Biological process","name":"DNA integration"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01072"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"16517682","citationType":"journal article","authors":["Tuffin I.M.","Hector S.B.","Deane S.M.","Rawlings D.E."],"citationCrossReferences":[{"database":"PubMed","id":"16517682"},{"database":"DOI","id":"10.1128/AEM.72.3.2247-2253.2006"}],"title":"Resistance determinants of a highly arsenic-resistant strain of Leptospirillum ferriphilum isolated from a commercial biooxidation tank.","publicationDate":"2006","journal":"Appl. Environ. Microbiol.","firstPage":"2247","lastPage":"2253","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85165.1"}],"value":"Fairview","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAY85165.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ057986","properties":[{"key":"ProteinId","value":"AAY85165.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q2LMN9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000150","properties":[{"key":"GoTerm","value":"F:DNA strand exchange activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0015074","properties":[{"key":"GoTerm","value":"P:DNA integration"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00569","properties":[{"key":"EntryName","value":"HTH_Hin_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd03768","properties":[{"key":"EntryName","value":"SR_ResInv"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.60","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1390","properties":[{"key":"EntryName","value":"Resolvase, N-terminal catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009057","properties":[{"key":"EntryName","value":"Homeodomain-like_sf"}]},{"database":"InterPro","id":"IPR006118","properties":[{"key":"EntryName","value":"Recombinase_CS"}]},{"database":"InterPro","id":"IPR006119","properties":[{"key":"EntryName","value":"Resolv_N"}]},{"database":"InterPro","id":"IPR036162","properties":[{"key":"EntryName","value":"Resolvase-like_N_sf"}]},{"database":"InterPro","id":"IPR006120","properties":[{"key":"EntryName","value":"Resolvase_HTH_dom"}]},{"database":"InterPro","id":"IPR050639","properties":[{"key":"EntryName","value":"SSR_resolvase"}]},{"database":"PANTHER","id":"PTHR30461","properties":[{"key":"EntryName","value":"DNA-INVERTASE FROM LAMBDOID PROPHAGE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR30461:SF26","properties":[{"key":"EntryName","value":"RESOLVASE HOMOLOG YNEB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02796","properties":[{"key":"EntryName","value":"HTH_7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00239","properties":[{"key":"EntryName","value":"Resolvase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00857","properties":[{"key":"EntryName","value":"Resolvase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46689","properties":[{"key":"EntryName","value":"Homeodomain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53041","properties":[{"key":"EntryName","value":"Resolvase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00397","properties":[{"key":"EntryName","value":"RECOMBINASES_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00398","properties":[{"key":"EntryName","value":"RECOMBINASES_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51736","properties":[{"key":"EntryName","value":"RECOMBINASES_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQGQRIGYVRVSSFDQNPERQLEQAEVGKVFTDKASGKDTQRPELDSLLAFVREGDTVVVHSMDRLARNLDDLRRLVQKLTKRGVRIEFVKECLTFTGEDSPMANLMLSVMGAFAEFERALIRERQKEGIALAKQRGAYRGRKKALSPERAAELLQRVNAGEQKAKLAREFGISRETLYQYLREIRA","length":187,"molWeight":21361,"crc64":"DB5566C9CFDB241A","md5":"2D0BEB0445702ADF91A112EA9A64B066"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Active site":1},"uniParcId":"UPI0000683F5D"}}]}