{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EC24","uniProtkbId":"A0AAF0EC24_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":11,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22384.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364024"}],"value":"RNA polymerase II transcription factor B subunit 2"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22384.1"}],"value":"RAD54"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22384.1"}],"value":"MEQU1_001054"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364024"}],"value":"Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002817"}],"value":"Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00094237"}],"value":"Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:65296"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:156439"},{"database":"ChEBI","id":"CHEBI:156440"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048592"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:65297"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048592"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:48256"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57337"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:88166"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049552"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:48257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049552"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43780"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57336"},{"database":"ChEBI","id":"CHEBI:57337"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"}],"ecNumber":"1.3.8.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048235"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43781"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048235"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:44180"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57338"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:62500"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051903"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:44181"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051903"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048778"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:13066"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048778"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:47196"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:87487"},{"database":"ChEBI","id":"CHEBI:87488"}],"ecNumber":"1.3.8.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051002"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:47197"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00051002"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:24004"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57332"},{"database":"ChEBI","id":"CHEBI:57371"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049096"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:24005"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049096"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:43464"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:62077"},{"database":"ChEBI","id":"CHEBI:62620"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049192"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:43465"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049192"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:65344"},{"database":"Rhea","id":"RHEA-COMP:10685"},{"database":"Rhea","id":"RHEA-COMP:10686"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57692"},{"database":"ChEBI","id":"CHEBI:58307"},{"database":"ChEBI","id":"CHEBI:156457"},{"database":"ChEBI","id":"CHEBI:156458"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048307"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:65345"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048307"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"FAD","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001974"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:57692"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037895"}],"value":"Amino-acid degradation; L-isoleucine degradation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005198"}],"value":"Lipid metabolism; mitochondrial fatty acid beta-oxidation"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011881"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004305"}],"value":"Mitochondrion matrix","id":"SL-0170"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364024"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007025"}],"value":"Belongs to the SNF2/RAD54 helicase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364024"}],"value":"Belongs to the TFB2 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009347"}],"value":"Belongs to the acyl-CoA dehydrogenase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Helicase ATP-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51192"}]},{"type":"Domain","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"Helicase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51194"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00541"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364024"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364024"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022827"}],"id":"KW-0274","category":"Ligand","name":"FAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022832"}],"id":"KW-0276","category":"Biological process","name":"Fatty acid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00541"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00541"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364024"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364024"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU364024"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22384.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22384.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119901","properties":[{"key":"ProteinId","value":"WFD22384.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000439","properties":[{"key":"GoTerm","value":"C:transcription factor TFIIH core complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0001671","properties":[{"key":"GoTerm","value":"F:ATPase activator activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015616","properties":[{"key":"GoTerm","value":"F:DNA translocase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016817","properties":[{"key":"GoTerm","value":"F:hydrolase activity, acting on acid anhydrides"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003853","properties":[{"key":"GoTerm","value":"F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0046395","properties":[{"key":"GoTerm","value":"P:carboxylic acid catabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045003","properties":[{"key":"GoTerm","value":"P:double-strand break repair via synthesis-dependent strand annealing"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006631","properties":[{"key":"GoTerm","value":"P:fatty acid metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006289","properties":[{"key":"GoTerm","value":"P:nucleotide-excision repair"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007131","properties":[{"key":"GoTerm","value":"P:reciprocal meiotic recombination"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01158","properties":[{"key":"EntryName","value":"SCAD_SBCAD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd18793","properties":[{"key":"EntryName","value":"SF2_C_SNF"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.540.10:FF:000012","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase short/branched chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.140.10:FF:000002","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase short/branched chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.40.110.10:FF:000001","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.10810:FF:000010","properties":[{"key":"EntryName","value":"DNA repair and recombination protein RAD54-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000332","properties":[{"key":"EntryName","value":"DNA repair and recombination protein RAD54-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.2610","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.540.10","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase/oxidase, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.110.10","properties":[{"key":"EntryName","value":"Butyryl-CoA Dehydrogenase, subunit A, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.140.10","properties":[{"key":"EntryName","value":"Butyryl-CoA Dehydrogenase, subunit A, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.850","properties":[{"key":"EntryName","value":"SWI2/SNF2 ATPases, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.10810","properties":[{"key":"EntryName","value":"Tandem AAA-ATPase domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006089","properties":[{"key":"EntryName","value":"Acyl-CoA_DH_CS"}]},{"database":"InterPro","id":"IPR046373","properties":[{"key":"EntryName","value":"Acyl-CoA_Oxase/DH_mid-dom_sf"}]},{"database":"InterPro","id":"IPR036250","properties":[{"key":"EntryName","value":"AcylCo_DH-like_C"}]},{"database":"InterPro","id":"IPR009075","properties":[{"key":"EntryName","value":"AcylCo_DH/oxidase_C"}]},{"database":"InterPro","id":"IPR006091","properties":[{"key":"EntryName","value":"AcylCoA_DH/ox_M"}]},{"database":"InterPro","id":"IPR013786","properties":[{"key":"EntryName","value":"AcylCoA_DH/ox_N"}]},{"database":"InterPro","id":"IPR037069","properties":[{"key":"EntryName","value":"AcylCoA_DH/ox_N_sf"}]},{"database":"InterPro","id":"IPR009100","properties":[{"key":"EntryName","value":"AcylCoA_DH/oxidase_NM_dom_sf"}]},{"database":"InterPro","id":"IPR014001","properties":[{"key":"EntryName","value":"Helicase_ATP-bd"}]},{"database":"InterPro","id":"IPR001650","properties":[{"key":"EntryName","value":"Helicase_C-like"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR013967","properties":[{"key":"EntryName","value":"Rad54_N"}]},{"database":"InterPro","id":"IPR038718","properties":[{"key":"EntryName","value":"SNF2-like_sf"}]},{"database":"InterPro","id":"IPR049730","properties":[{"key":"EntryName","value":"SNF2/RAD54-like_C"}]},{"database":"InterPro","id":"IPR000330","properties":[{"key":"EntryName","value":"SNF2_N"}]},{"database":"InterPro","id":"IPR050496","properties":[{"key":"EntryName","value":"SNF2_RAD54_helicase_repair"}]},{"database":"InterPro","id":"IPR040662","properties":[{"key":"EntryName","value":"Tfb2_C"}]},{"database":"InterPro","id":"IPR004598","properties":[{"key":"EntryName","value":"TFIIH_p52/Tfb2"}]},{"database":"PANTHER","id":"PTHR45629:SF7","properties":[{"key":"EntryName","value":"DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45629","properties":[{"key":"EntryName","value":"SNF2/RAD54 FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00441","properties":[{"key":"EntryName","value":"Acyl-CoA_dh_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02770","properties":[{"key":"EntryName","value":"Acyl-CoA_dh_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02771","properties":[{"key":"EntryName","value":"Acyl-CoA_dh_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00271","properties":[{"key":"EntryName","value":"Helicase_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08658","properties":[{"key":"EntryName","value":"Rad54_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00176","properties":[{"key":"EntryName","value":"SNF2-rel_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03849","properties":[{"key":"EntryName","value":"Tfb2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18307","properties":[{"key":"EntryName","value":"Tfb2_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00487","properties":[{"key":"EntryName","value":"DEXDc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00490","properties":[{"key":"EntryName","value":"HELICc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47203","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56645","properties":[{"key":"EntryName","value":"Acyl-CoA dehydrogenase NM domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00072","properties":[{"key":"EntryName","value":"ACYL_COA_DH_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00073","properties":[{"key":"EntryName","value":"ACYL_COA_DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51192","properties":[{"key":"EntryName","value":"HELICASE_ATP_BIND_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51194","properties":[{"key":"EntryName","value":"HELICASE_CTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPKKKSSLEGVYKGIDASGVSLNADRRKWAVYQARPDAIKSKFNIPSMKNERGEVIETRLTHASLGVRRPIEVPPRPLHDPMGEHAIVLFDPTIDDKDAEKERERTRIEFEEQKKALEVDRGPHKSLARILGIDQPKVVMEKVPVVIDPRLGRILRPHQVEGVKFLYRCTTGMVSENAHGCIMADEMGLGKTLQCITLMWTLLRQSPRAGKGTIDKAIVVCPSSLVRNWANELVKWLGASAPGALALDGKLSREDMFQAVDRWAKAKGRAIVQPVMIVSYETLRNLQELLGNTEIGLMLCDEGHRLKNADSLTFQSLDLLKVQRRVILSGTPIQNDLSEYFSLINFAIPDILGNRNEFRKRFELDILRGRDAEATDKEKQIGKEKLQELSGLVSQFIIRRTNDILSKYLPVKYEHVVFCNLSPFQLDLYHLFLRAPAIEKMLKGTVSQPLKAIGVLKKLCNHPDLLNLPEDLEGSEDCFPEGYKPGDRRNVAVHLSGKMAILERFLTTMRTTTDDKIVLISNYTQTLDLFERLCRSRRWGFFRLDGTMNISKRQKLVDRFNDPEAPEFVFLLSSKAGGCGLNLIGANRLVLFDPDWNPASDQQALARVWRDGQKKTCFVYRFVATGSIEEKILQRQSHKQSLSSCVVDDDLDAERHFSGEILRALFQYKSGTVSDTHDTYKCKRCRDGKQIVSSQAMLYGDTSTMSNCMKFFQIQNEEEPLEQMQRLSILMVKGEEVYMNDVFRRGMVGALTGSGDSASFGKPCADSNHKSVPIEFLDEYARTQWETILYFMVGSEHSSRPRNTVLFLLQRAGLMQRGSGGDDLNITSLGFQFLLQDVNSQLWALLLHYLSMAEERNMDLVEVLSFFFTVGGLELGRAYETQGLSMTQMQTLEELSDYGLVYRPSKSVKYFFPTRLASTLTSTASPSISRLNDQEEQGYLILETNYRVYAYTCTSHVKSALNKGITADQIITYLSHHAHPQMYKNWARIPVADTPGNLYTDFTSMEDFVQVRDYAKSLSVLQWESEAKRMLFVTAEGHAQSPPTMSMRMLARSSTALRSMARSAVSARTVGAVRVPQVARTSVQAARALSSSALRAGEYENPFGPNSLYKLTEEEEMLREAVRRFAETEVQPRVAEMDEKEKMDPKIIQGLFEQGLMAIETDPELGGAGSGFLSAILVIEELAKVDPSVSVLCDVHNTLVNTVLRKYANEHLKKKYMPSLSIDKLGSFCLSEPGSGSDAFAMRTSVKKSEDGQHYIINGSKMWITNSGEAEFFIVFAQGDPSKGYKGISAFAVEKEMGVEIAKKESKLGIRASSTCTVNFDDVKVPAENLIGEEGKGYKIAIEILNEGRVGIGAQMVGLAQGAYDKAMAYTFERQQFGQPIAKFQGMQFQMGQIAAEIEAARLMVYNAARLKEEGRPFTKQAAMAKLISSQVAERAAGKAIEWLGGQGFTREQGVEKYWRDSKIGAIYEGTSNIQLNTIFNLTAKERGF","length":1489,"molWeight":166961,"crc64":"DE53BAD5060381AC","md5":"0655BD5D147F7BB03276EC8E53E39724"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"CATALYTIC ACTIVITY":9,"COFACTOR":1,"PATHWAY":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":3},"countByFeatureType":{"Domain":2},"uniParcId":"UPI00279FB62E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EFF5","uniProtkbId":"A0AAF0EFF5_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":8,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23418.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Pentafunctional AROM polypeptide"}},"includes":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"3-dehydroquinate synthase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"DHQS"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"4.2.3.4"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"3-phosphoshikimate 1-carboxyvinyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"2.5.1.19"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"5-enolpyruvylshikimate-3-phosphate synthase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"EPSP synthase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"EPSPS"}]}]},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Shikimate kinase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"SK"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"2.7.1.71"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"3-dehydroquinate dehydratase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"3-dehydroquinase"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"4.2.1.10"}]}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Shikimate dehydrogenase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"1.1.1.25"}]}}]},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23418.1"}],"value":"MEQU1_002107"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-dehydroquinate = 3-dehydroshikimate + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21096"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:16630"},{"database":"ChEBI","id":"CHEBI:32364"}],"ecNumber":"4.2.1.10","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21256"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57701"},{"database":"ChEBI","id":"CHEBI:58702"},{"database":"ChEBI","id":"CHEBI:145989"}],"ecNumber":"2.5.1.19","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21257"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044633"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21968"},{"database":"ChEBI","id":"CHEBI:32364"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58394"}],"ecNumber":"4.2.3.4","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69851"},{"database":"Rhea","id":"RHEA-COMP:14658"},{"database":"Rhea","id":"RHEA-COMP:17789"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:65315"},{"database":"ChEBI","id":"CHEBI:74443"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048342"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:69853"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048342"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:69855"},{"database":"Rhea","id":"RHEA-COMP:14658"},{"database":"Rhea","id":"RHEA-COMP:17789"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"},{"database":"ChEBI","id":"CHEBI:65315"},{"database":"ChEBI","id":"CHEBI:74443"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049447"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:69857"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049447"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"shikimate + ATP = 3-phosphoshikimate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13121"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:36208"},{"database":"ChEBI","id":"CHEBI:145989"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.71","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048567"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17737"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16630"},{"database":"ChEBI","id":"CHEBI:36208"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.1.1.25","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"FMN","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001917"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58210"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Binds 2 Zn(2+) ions per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004842"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004811"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009948"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004164"}],"value":"Belongs to the EPSP synthase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"In the 2nd section; belongs to the EPSP synthase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006477"}],"value":"In the 2nd section; belongs to the type-I 3-dehydroquinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"In the 3rd section; belongs to the shikimate kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"In the 4th section; belongs to the type-I 3-dehydroquinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"In the C-terminal section; belongs to the shikimate dehydrogenase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009349"}],"value":"In the N-terminal section; belongs to the shikimate kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"DUS-like FMN-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01207"}]},{"type":"Domain","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":560,"modifier":"EXACT"}},"description":"3-dehydroquinate synthase N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01761"}]},{"type":"Domain","location":{"start":{"value":562,"modifier":"EXACT"},"end":{"value":737,"modifier":"EXACT"}},"description":"3-dehydroquinate synthase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24621"}]},{"type":"Domain","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":1207,"modifier":"EXACT"}},"description":"Enolpyruvate transferase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00275"}]},{"type":"Domain","location":{"start":{"value":1653,"modifier":"EXACT"},"end":{"value":1734,"modifier":"EXACT"}},"description":"Shikimate dehydrogenase substrate binding N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF08501"}]},{"type":"Domain","location":{"start":{"value":1758,"modifier":"EXACT"},"end":{"value":1839,"modifier":"EXACT"}},"description":"Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01488"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"3-dehydroquinate synthase","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]},{"type":"Region","location":{"start":{"value":1648,"modifier":"EXACT"},"end":{"value":1934,"modifier":"EXACT"}},"description":"Shikimate dehydrogenase","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]},{"type":"Active site","location":{"start":{"value":639,"modifier":"EXACT"},"end":{"value":639,"modifier":"EXACT"}},"description":"Proton acceptor; for 3-dehydroquinate synthase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]},{"type":"Active site","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"Proton acceptor; for 3-dehydroquinate synthase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]},{"type":"Active site","location":{"start":{"value":1195,"modifier":"EXACT"},"end":{"value":1195,"modifier":"EXACT"}},"description":"For EPSP synthase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]},{"type":"Active site","location":{"start":{"value":1539,"modifier":"EXACT"},"end":{"value":1539,"modifier":"EXACT"}},"description":"Proton acceptor; for 3-dehydroquinate dehydratase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]},{"type":"Active site","location":{"start":{"value":1567,"modifier":"EXACT"},"end":{"value":1567,"modifier":"EXACT"}},"description":"Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}]},{"type":"Binding site","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":457,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":490,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":517,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":532,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":533,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":553,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":561,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57540"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"NAD(+)","id":"ChEBI:CHEBI:57540"}},{"type":"Binding site","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":565,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":629,"modifier":"EXACT"},"end":{"value":629,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":643,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":650,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":650,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":735,"modifier":"EXACT"},"end":{"value":735,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58394"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate","id":"ChEBI:CHEBI:58394"}},{"type":"Binding site","location":{"start":{"value":1251,"modifier":"EXACT"},"end":{"value":1258,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023141"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0057","category":"Biological process","name":"Aromatic amino acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022664"}],"id":"KW-0507","category":"Biological process","name":"mRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022694"}],"id":"KW-0819","category":"Biological process","name":"tRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03143"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23418.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23418.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119903","properties":[{"key":"ProteinId","value":"WFD23418.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003855","properties":[{"key":"GoTerm","value":"F:3-dehydroquinate dehydratase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003856","properties":[{"key":"GoTerm","value":"F:3-dehydroquinate synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003866","properties":[{"key":"GoTerm","value":"F:3-phosphoshikimate 1-carboxyvinyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0050660","properties":[{"key":"GoTerm","value":"F:flavin adenine dinucleotide binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004764","properties":[{"key":"GoTerm","value":"F:shikimate 3-dehydrogenase (NADP+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004765","properties":[{"key":"GoTerm","value":"F:shikimate kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0017150","properties":[{"key":"GoTerm","value":"F:tRNA dihydrouridine synthase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0009073","properties":[{"key":"GoTerm","value":"P:aromatic amino acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0009423","properties":[{"key":"GoTerm","value":"P:chorismate biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00502","properties":[{"key":"EntryName","value":"DHQase_I"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd08195","properties":[{"key":"EntryName","value":"DHQS"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd02801","properties":[{"key":"EntryName","value":"DUS_like_FMN"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01556","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01065","properties":[{"key":"EntryName","value":"NAD_bind_Shikimate_DH"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00464","properties":[{"key":"EntryName","value":"SK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.70:FF:000135","properties":[{"key":"EntryName","value":"Pentafunctional AROM polypeptide"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1970:FF:000007","properties":[{"key":"EntryName","value":"Pentafunctional AROM polypeptide"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.65.10.10:FF:000007","properties":[{"key":"EntryName","value":"Pentafunctional AROM polypeptide"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1970","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.1090.10","properties":[{"key":"EntryName","value":"Dehydroquinate synthase-like - alpha domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.65.10.10","properties":[{"key":"EntryName","value":"Enolpyruvate transferase domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.10860","properties":[{"key":"EntryName","value":"Leucine Dehydrogenase, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00210","properties":[{"key":"EntryName","value":"EPSP_synth"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03143","properties":[{"key":"EntryName","value":"Pentafunct_AroM"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00109","properties":[{"key":"EntryName","value":"Shikimate_kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR046346","properties":[{"key":"EntryName","value":"Aminoacid_DH-like_N_sf"}]},{"database":"InterPro","id":"IPR016037","properties":[{"key":"EntryName","value":"DHQ_synth_AroB"}]},{"database":"InterPro","id":"IPR030960","properties":[{"key":"EntryName","value":"DHQS/DOIS_N"}]},{"database":"InterPro","id":"IPR056179","properties":[{"key":"EntryName","value":"DHQS_C"}]},{"database":"InterPro","id":"IPR001381","properties":[{"key":"EntryName","value":"DHquinase_I"}]},{"database":"InterPro","id":"IPR035587","properties":[{"key":"EntryName","value":"DUS-like_FMN-bd"}]},{"database":"InterPro","id":"IPR001986","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_dom"}]},{"database":"InterPro","id":"IPR036968","properties":[{"key":"EntryName","value":"Enolpyruvate_Tfrase_sf"}]},{"database":"InterPro","id":"IPR006264","properties":[{"key":"EntryName","value":"EPSP_synthase"}]},{"database":"InterPro","id":"IPR023193","properties":[{"key":"EntryName","value":"EPSP_synthase_CS"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR008289","properties":[{"key":"EntryName","value":"Pentafunct_AroM"}]},{"database":"InterPro","id":"IPR013792","properties":[{"key":"EntryName","value":"RNA3'P_cycl/enolpyr_Trfase_a/b"}]},{"database":"InterPro","id":"IPR031322","properties":[{"key":"EntryName","value":"Shikimate/glucono_kinase"}]},{"database":"InterPro","id":"IPR013708","properties":[{"key":"EntryName","value":"Shikimate_DH-bd_N"}]},{"database":"InterPro","id":"IPR010110","properties":[{"key":"EntryName","value":"Shikimate_DH_AroM-type"}]},{"database":"InterPro","id":"IPR000623","properties":[{"key":"EntryName","value":"Shikimate_kinase/TSH1"}]},{"database":"InterPro","id":"IPR023000","properties":[{"key":"EntryName","value":"Shikimate_kinase_CS"}]},{"database":"InterPro","id":"IPR006151","properties":[{"key":"EntryName","value":"Shikm_DH/Glu-tRNA_Rdtase"}]},{"database":"InterPro","id":"IPR018517","properties":[{"key":"EntryName","value":"tRNA_hU_synthase_CS"}]},{"database":"NCBIfam","id":"TIGR01356","properties":[{"key":"EntryName","value":"aroA"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01357","properties":[{"key":"EntryName","value":"aroB"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01093","properties":[{"key":"EntryName","value":"aroD"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01809","properties":[{"key":"EntryName","value":"Shik-DH-AROM"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090","properties":[{"key":"EntryName","value":"AROM/DEHYDROQUINATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21090:SF5","properties":[{"key":"EntryName","value":"PENTAFUNCTIONAL AROM POLYPEPTIDE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01761","properties":[{"key":"EntryName","value":"DHQ_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24621","properties":[{"key":"EntryName","value":"DHQS_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01487","properties":[{"key":"EntryName","value":"DHquinase_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01207","properties":[{"key":"EntryName","value":"Dus"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00275","properties":[{"key":"EntryName","value":"EPSP_synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01488","properties":[{"key":"EntryName","value":"Shikimate_DH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08501","properties":[{"key":"EntryName","value":"Shikimate_dh_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01202","properties":[{"key":"EntryName","value":"SKI"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01100","properties":[{"key":"EntryName","value":"SHIKIMTKNASE"}]},{"database":"SUPFAM","id":"SSF51569","properties":[{"key":"EntryName","value":"Aldolase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53223","properties":[{"key":"EntryName","value":"Aminoacid dehydrogenase-like, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56796","properties":[{"key":"EntryName","value":"Dehydroquinate synthase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55205","properties":[{"key":"EntryName","value":"EPT/RTPC-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51395","properties":[{"key":"EntryName","value":"FMN-linked oxidoreductases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00104","properties":[{"key":"EntryName","value":"EPSP_SYNTHASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00885","properties":[{"key":"EntryName","value":"EPSP_SYNTHASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01128","properties":[{"key":"EntryName","value":"SHIKIMATE_KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01136","properties":[{"key":"EntryName","value":"UPF0034"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTSLRAEECVDEGRTKRLKLDTAMPPPSDPRMPAFDRGLFLAPMVRIGSLPSRLLALEYGADLVWSPEIVDRAIMGTTRRVNATTGLVEFMKGDKQIFSCHPVERPYLIYQVGSSTPENAAEAVRIVTAHDDVAGVDLNCGCPKPFSTLGGMGANLLTEPDLLCDILRQMRRAAPPHVSVTCKIRLLPTQAETLALVEQIVRTRTIRALTIHCRTKPMRPREPALVDRFREIAEHVQKVAAETGQDVPVIYNGDCFGASDWPRLRERTGASAVMMARAAELNPSCFQLQRQCVATVIAPRWMHYAVRFDNPFGNTKYCVTQLAFSTWAGARECEAPRASTGEPGEELPIPTMSEAGGGHKVPSYHAPPYTSELSGATIHELRCLDTRIQLGFHLVPHIVQTLYAELPTSSYVLFTDAHLEALGVIDKFREAFETYKPEGNTSRMLAHVLPPGEESKSRETKAGIEDWMLEHRLTRDTVVLACGGGVIGDLVGFVAATFMRGLKYVQIPTTLLAMVDSAVGGKTAIDHPHGKNLIGAFHQPQFVFVDAAWLLTLPEREFANGMAEVVKTAAIWDADDFDKLESESQSIQAAVLSDEARSAPAGLGHTLDTRTPSQTLLLDVIRGSIGVKAHIVTIDEKETGLRNLVNFGHSVGHAIEAVLTPAILHGECVAVGMIFEAEIARAMHGLPQVVIGRLVRALTNYGLPVSLKDARIAALPQAQAITTARLLDIMRVDKKNAGTAKKIVLLSRIGATVEERASTVPDAVIARVLAPSVQVGSSLGTPREPVTLPTPGSKSVSNRALVLAALAQGTCRLRNLLHSDDTQVMMNALRTLRAADFAWEEDGAQLVVHGGGGRLVACDKPVYLQNAGTAARFMTGVTTLLREGTVTLTGNARMKQRPIGPLVEALCANGAAIACVEAPGALPLRITGRGGLQGGVIRLAADVSSQYVSAVLLCAPYAQEAVTLELVGGKVISQPYIDMTVAMMQSFGVQVERVAEHVYRIPQQVYRAPDVYTVESDASSATYPLAMAAITGTTVTVPSIGSASLQGDARFARDVLAPMGCHVEQTEASTTVTGPPPGTLRQLNEVDMEPMTDAFMTAAVLFAVAQGTSTKITGIANQRVKECDRLRATVTELAKFGVQAHEHDDGIVVYGRPLSELQTSEPIACYDDHRIAMAFSVLASVVPSTRTTLEEKRCVEKTWPSWWDVLSTQLCVPIAAADEDVSLVPLPRASATLHGLPHRYAPDATIVLIGMRASGKSHIGRRLAARMHRTFVDADDVFSQRFDLSAFVAQHGWDAFRMEETRVLEQLLRDCARGHVLALGGGVVESAASRALLTAFQRTGPVVHIVRRYEDIEAFLATSDRPAYGEPLRTVYDRRQPWYEACACMETVNEGDVVTLLERQLATPLGAPGKERPAFFLSLTFPHVRDALPVLATASAGVDVLELRVDLLHPSGVPSIDEVRAQVALLRQHSSLPILYTVRSASEGGRCPDDNEQAYWALVRLGLRLGCEWVDVELRRSADYGRALRAQDVASRIVASAHDTTGQMPWSSSAIARLYERGRQEGDVVKLVGVARTVQDNMALEHFRTAVARDTSTLIAINMHAAGQLSRVLNPLLTPVTHPRLPSKAAPGQLSVQEIHQARHLLGLLPAQRFALLGSPIAHSLSPLIHNTSFELLGLPHKYALHETASVEESVAALIRAPDFGGASVTIPHKCAITSLLHTLSPEAEAIGAVNTVVPQRDAGRLWLRGENTDWQAIYELAQRARPSAHTALVIGAGGSARAALYAMHRLGVSTILLYNRTYAKAMELAAAVPTEWHVQPLKTLSDAVAQAPDVIVSNVPAAGTSLTPGGADIVLPADLLSSAGGVAIDMAYRPEKTPLLTLVEQNPAWHGVRGLEILLTQAFHQFHLWTGLPAPHDEVARAAWQAYHAQAEAHST","length":1934,"molWeight":209009,"crc64":"98DE120A329F6C8C","md5":"5233E87EEBE7051D7B2B176F0FF2EDFE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":7,"COFACTOR":2,"PATHWAY":5,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":8,"CAUTION":1},"countByFeatureType":{"Domain":6,"Region":2,"Active site":5,"Binding site":21},"uniParcId":"UPI0027A47CF3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EAG0","uniProtkbId":"A0AAF0EAG0_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":11,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22752.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012639"}],"value":"ATP citrate synthase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012639"}],"value":"2.3.3.8"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030151"}],"value":"ATP-citrate (pro-S-)-lyase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076189"}],"value":"ATP-citrate (pro-S-)-lyase 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00030982"}],"value":"Citrate cleavage enzyme"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00083544"}],"value":"Citrate cleavage enzyme subunit 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22752.1"}],"value":"acl1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22752.1"}],"value":"MEQU1_001429"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00093367"}],"value":"Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00054002"}],"value":"Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21160"},{"database":"ChEBI","id":"CHEBI:16452"},{"database":"ChEBI","id":"CHEBI:16947"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.3.3.8","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047593"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062455"}],"value":"Composed of two subunits"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011881"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00060724"}],"value":"Belongs to the succinate/malate CoA ligase alpha subunit family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005899"}],"value":"In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010719"}],"value":"In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":546,"modifier":"EXACT"}},"description":"Gamma tubulin complex component protein N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF17681"}]},{"type":"Domain","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":844,"modifier":"EXACT"}},"description":"Gamma tubulin complex component C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04130"}]},{"type":"Domain","location":{"start":{"value":913,"modifier":"EXACT"},"end":{"value":1167,"modifier":"EXACT"}},"description":"ATP-citrate synthase ATP-grasp","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF24948"}]},{"type":"Domain","location":{"start":{"value":1203,"modifier":"EXACT"},"end":{"value":1380,"modifier":"EXACT"}},"description":"ATP-citrate synthase citrate-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF16114"}]},{"type":"Domain","location":{"start":{"value":1454,"modifier":"EXACT"},"end":{"value":1559,"modifier":"EXACT"}},"description":"CoA-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF02629"}]},{"type":"Domain","location":{"start":{"value":1619,"modifier":"EXACT"},"end":{"value":1743,"modifier":"EXACT"}},"description":"ATP-citrate synthase/succinyl-CoA ligase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00549"}]},{"type":"Region","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1393,"modifier":"EXACT"},"end":{"value":1423,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1393,"modifier":"EXACT"},"end":{"value":1419,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22752.1"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022516"}],"id":"KW-0444","category":"Biological process","name":"Lipid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022701"}],"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22752.1"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22752.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22752.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119902","properties":[{"key":"ProteinId","value":"WFD22752.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000930","properties":[{"key":"GoTerm","value":"C:gamma-tubulin complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005816","properties":[{"key":"GoTerm","value":"C:spindle pole body"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0003878","properties":[{"key":"GoTerm","value":"F:ATP citrate synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0043015","properties":[{"key":"GoTerm","value":"F:gamma-tubulin binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006085","properties":[{"key":"GoTerm","value":"P:acetyl-CoA biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006633","properties":[{"key":"GoTerm","value":"P:fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007020","properties":[{"key":"GoTerm","value":"P:microtubule nucleation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd06100","properties":[{"key":"EntryName","value":"CCL_ACL-C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.261:FF:000003","properties":[{"key":"EntryName","value":"ATP-citrate synthase subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.261:FF:000004","properties":[{"key":"EntryName","value":"ATP-citrate synthase subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.230.10:FF:000005","properties":[{"key":"EntryName","value":"ATP-citrate synthase subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.470.110:FF:000003","properties":[{"key":"EntryName","value":"ATP-citrate synthase subunit 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000024","properties":[{"key":"EntryName","value":"Probable ATP-citrate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.470.110","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.230.10","properties":[{"key":"EntryName","value":"Cytochrome P450-Terp, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.1900","properties":[{"key":"EntryName","value":"Gamma-tubulin complex, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.261","properties":[{"key":"EntryName","value":"Succinyl-CoA synthetase domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR017440","properties":[{"key":"EntryName","value":"Cit_synth/succinyl-CoA_lig_AS"}]},{"database":"InterPro","id":"IPR032263","properties":[{"key":"EntryName","value":"Citrate-bd"}]},{"database":"InterPro","id":"IPR016143","properties":[{"key":"EntryName","value":"Citrate_synth-like_sm_a-sub"}]},{"database":"InterPro","id":"IPR056749","properties":[{"key":"EntryName","value":"Citrate_synth_N"}]},{"database":"InterPro","id":"IPR002020","properties":[{"key":"EntryName","value":"Citrate_synthase"}]},{"database":"InterPro","id":"IPR036969","properties":[{"key":"EntryName","value":"Citrate_synthase_sf"}]},{"database":"InterPro","id":"IPR033847","properties":[{"key":"EntryName","value":"Citrt_syn/SCS-alpha_CS"}]},{"database":"InterPro","id":"IPR003781","properties":[{"key":"EntryName","value":"CoA-bd"}]},{"database":"InterPro","id":"IPR040457","properties":[{"key":"EntryName","value":"GCP_C"}]},{"database":"InterPro","id":"IPR042241","properties":[{"key":"EntryName","value":"GCP_C_sf"}]},{"database":"InterPro","id":"IPR041470","properties":[{"key":"EntryName","value":"GCP_N"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR005811","properties":[{"key":"EntryName","value":"SUCC_ACL_C"}]},{"database":"InterPro","id":"IPR016102","properties":[{"key":"EntryName","value":"Succinyl-CoA_synth-like"}]},{"database":"PANTHER","id":"PTHR23118","properties":[{"key":"EntryName","value":"ATP-CITRATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23118:SF42","properties":[{"key":"EntryName","value":"ATP-CITRATE SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16114","properties":[{"key":"EntryName","value":"Citrate_bind"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00285","properties":[{"key":"EntryName","value":"Citrate_synt"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24948","properties":[{"key":"EntryName","value":"Citrate_synth_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02629","properties":[{"key":"EntryName","value":"CoA_binding"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04130","properties":[{"key":"EntryName","value":"GCP_C_terminal"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17681","properties":[{"key":"EntryName","value":"GCP_N_terminal"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00549","properties":[{"key":"EntryName","value":"Ligase_CoA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48256","properties":[{"key":"EntryName","value":"Citrate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56059","properties":[{"key":"EntryName","value":"Glutathione synthetase ATP-binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52210","properties":[{"key":"EntryName","value":"Succinyl-CoA synthetase domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01216","properties":[{"key":"EntryName","value":"SUCCINYL_COA_LIG_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00399","properties":[{"key":"EntryName","value":"SUCCINYL_COA_LIG_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSAKQYDRYLRRLSAVQHSTRRAMRTALDDSVQEEAHELEAGEEATPVARTPAERTRALPPQIRHLERGGNAPSIAPMPESYLQESSFVLNPLGGRLPSMTPRKLARPRAYDVEDPNESVERLANVDDRILALDTLDATLQDVVLVEDLLYVLMGIEGNYVQFAPEYQPDDLGHRLNGARYVIDAALHPSLRELVERILPLASYYTSIYAFVECESGLEYGTVMHALCAAIRAQLRQYEDLVAQMEQRMLSSPDFTLQQLWRVMHPMLRTFGLVHALTSDIASITHADVLPRPEDENVSEGSDASIDSDASQLERDRRALLGLDDFKSEDIVGGIVKGGEVLSMLWDRLTQLGGDPVAHALYLELFREASQPYARTLLRWITSGVLLDPYEEFMVVEDARVTRASLESDPTDEYWERRYMLRDERYLAQREQQARDGDMLPADEVDEARGELTGGAKIPAFLQPWKHKILLAGKYLNAIRECGIDVSNGQSERVKSLFGLQDAHVEAYLALDAKLERVVMDDEAFATCIERAYQRANAALLCLLKDDKDIIARLCSLKHYFFFAQSDFLQTFMDQSSHELRKMVDPYRIRETTLLRLQTQLDMALGSSDSVGFLDPYREDLRVDLAKERAYDQLQRIADTKGVVEVAKLRAKQQAERQQQGTREVVMYLLQFDVRVQFPVSLVISKKNILRWQFIHRCLLLFKQLERALTEVWVEQTMPAWRRKDRRVHAAPMEAWKMRIHLLRQRMLLLVQQLLAFYTSEIIEPHWHALERQLHAARSVDQFMKHHFDFLNTCRKECMLTDYRYLECHRKLMNTITAFTESRTRFMEQYESMQAAVDAWYERADDAAPPPVLLDERDILSKIEASWNKHSRGYHLDHPTLNSRATRHEESLYPSYCFPCRQNVCMHGRSCPAIHEFDAKLLINYWLPRSPDASPDAVASPSFCAPTARVAQLSWDANTQTLTPDERLPGWVFNSKLVAKPDQLIKRRGKAGLLKLNADWSDAKAWIAERAGQPQKVRPSRLTRQVEAVMGRLTHFLVEPFCPHAPETEFYVCINSAREGDYVLFTHEGGVDVGDVDAKAKKLLIPANPEEPFPPREQWTRTLLLEVGENKKELLTDFLLRLYSVYVDLHFAYLEINPLVVTDDQIYYLDMAAKLDQTADYLCGPKWAIAREPSVYGEVSASAGAALNEDRGPPMVWPAPFGRELTAEEAYISKLDAGTGASLKLTVLNAAGRIWTMVAGGGASVVYSDAIAAHGFAHELANYGEYSGAPTETQTFEYAKTLLDLMTRGEPHPDGKLLIIGGGIANFTNVAATFKGIIRALKQFKPLLIKHQVRIYVRRGGPNYQEGLRAMRLLGEELGVPIQVYGPETHITDIVPLALGLKRLEDMVLNETGPTVPTSVQTDVQAQPGPTESSSTNVGAVNPVTGERVQPQDQIVHFQTDGTPKRPWFMPFDEHTRSLVYGLQPRAIQGMLDFDFACGRDKPSVAAMVYPFGGHHIQKFYWGTKETLLPVYQSLQEAVKKHPDVDVVVNFASSRSVYASSLEVLAIPQIRALALIAEGVPERYAREILWRAKNASVLVIGPATVGGIKPGCFRIGNSGGMMDNIVASKLYRAGSVGYVSKSGGMSNELNNILSFTTNGTYEGIAIGGDRYPATTFIDHLLRYEKDPNCKMLVLLGEVGGVEEYRVIEAVKQGQITKPIVAWAIGTCAKMFTTEVQFGHAGSMANSEAETASAKNAAMRAAGFVVPDTFEDLPTVLRQTYERLVQNGTIQPKAERPPPPIPMDYKWAQELGMVRKPAAFISTISDERGAELMYSGVKISDVFGSNMGIGGVVSLLWFKRPLPPVCTKFIEMTLMLTADHGPAVSGAMNTIITSRAGKDLISSLVSGLLTIGDRFGGALDNAAREFSSAFDRGLTPREFVDSMRKANKLIPGIGHRIKSVSNPDYRVQVVKDYVQKNFESHKLLDYALAVEKVTTAKKDTLILNVDGCIAVCFVDLLRDSGAFTREEADEYVQIGALNGLFTLGRTIGFIGHHLDQKRLKTPLYRHPADDFHIEMATPSRVVGNYDPHHQ","length":2069,"molWeight":231990,"crc64":"EABE4D949993E85A","md5":"C31CC34D725191425DBBD5C415ADAA2E"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":1,"SUBUNIT":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":3},"countByFeatureType":{"Domain":6,"Region":3,"Compositional bias":1},"uniParcId":"UPI0027A5592C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EAV9","uniProtkbId":"A0AAF0EAV9_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":12,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22303.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22303.1"}],"value":"Carbamoyl-phosphate synthase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22303.1"}],"value":"URA2"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22303.1"}],"value":"MEQU1_000971"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-glutamine + H2O = L-glutamate + NH4(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15889"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:58359"}],"ecNumber":"3.5.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049534"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20013"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29991"},{"database":"ChEBI","id":"CHEBI:32814"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58228"}],"ecNumber":"2.1.3.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048859"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18633"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17544"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58228"},{"database":"ChEBI","id":"CHEBI:58359"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"6.3.5.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048816"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18029"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:17544"},{"database":"ChEBI","id":"CHEBI:28938"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:58228"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"6.3.4.16","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047359"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001947"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004812"}],"value":"Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004852"}],"value":"Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043998"}],"value":"In the 2nd section; belongs to the CarB family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043968"}],"value":"In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043979"}],"value":"In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043984"}],"value":"In the N-terminal section; belongs to the CarA family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":799,"modifier":"EXACT"}},"description":"ATP-grasp","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50975"}]},{"type":"Domain","location":{"start":{"value":1144,"modifier":"EXACT"},"end":{"value":1335,"modifier":"EXACT"}},"description":"ATP-grasp","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50975"}]},{"type":"Domain","location":{"start":{"value":1401,"modifier":"EXACT"},"end":{"value":1584,"modifier":"EXACT"}},"description":"MGS-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51855"}]},{"type":"Region","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00605"}]},{"type":"Active site","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00605"}]},{"type":"Active site","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00605"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00409"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00605"}],"id":"KW-0315","category":"Domain","name":"Glutamine amidotransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022598"}],"id":"KW-0436","category":"Molecular function","name":"Ligase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00409"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022975"}],"id":"KW-0665","category":"Biological process","name":"Pyrimidine biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22303.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22303.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119901","properties":[{"key":"ProteinId","value":"WFD22303.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016597","properties":[{"key":"GoTerm","value":"F:amino acid binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004070","properties":[{"key":"GoTerm","value":"F:aspartate carbamoyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004087","properties":[{"key":"GoTerm","value":"F:carbamoyl-phosphate synthase (ammonia) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004088","properties":[{"key":"GoTerm","value":"F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004151","properties":[{"key":"GoTerm","value":"F:dihydroorotase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004359","properties":[{"key":"GoTerm","value":"F:glutaminase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006207","properties":[{"key":"GoTerm","value":"P:'de novo' pyrimidine nucleobase biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0019240","properties":[{"key":"GoTerm","value":"P:L-citrulline biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006541","properties":[{"key":"GoTerm","value":"P:L-glutamine metabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006228","properties":[{"key":"GoTerm","value":"P:UTP biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01744","properties":[{"key":"EntryName","value":"GATase1_CPSase"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd01423","properties":[{"key":"EntryName","value":"MGS_CPS_I_III"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1370:FF:000002","properties":[{"key":"EntryName","value":"Aspartate carbamoyltransferase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1370:FF:000005","properties":[{"key":"EntryName","value":"CAD protein-like isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.1380:FF:000005","properties":[{"key":"EntryName","value":"CAD protein-like isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.20:FF:000011","properties":[{"key":"EntryName","value":"CAD protein-like isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.470.20:FF:000004","properties":[{"key":"EntryName","value":"Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.50.30.20:FF:000002","properties":[{"key":"EntryName","value":"Carbamoyl-phosphate synthase 1, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.1030.10:FF:000001","properties":[{"key":"EntryName","value":"Carbamoyl-phosphate synthase large chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.140:FF:000036","properties":[{"key":"EntryName","value":"Carbamoyl-phosphate synthase large chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.470.20:FF:000001","properties":[{"key":"EntryName","value":"Carbamoyl-phosphate synthase large chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.20:FF:000002","properties":[{"key":"EntryName","value":"Carbamoyl-phosphate synthase large chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.880","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1370","properties":[{"key":"EntryName","value":"Aspartate/ornithine carbamoyltransferase"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.1490.20","properties":[{"key":"EntryName","value":"ATP-grasp fold, A domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.470.20","properties":[{"key":"EntryName","value":"ATP-grasp fold, B domain"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.50.30.20","properties":[{"key":"EntryName","value":"Carbamoyl-phosphate synthase small subunit, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.1030.10","properties":[{"key":"EntryName","value":"Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.140","properties":[{"key":"EntryName","value":"Metal-dependent hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.1380","properties":[{"key":"EntryName","value":"Methylglyoxal synthase-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_00001","properties":[{"key":"EntryName","value":"Asp_carb_tr"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01209","properties":[{"key":"EntryName","value":"CPSase_S_chain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006132","properties":[{"key":"EntryName","value":"Asp/Orn_carbamoyltranf_P-bd"}]},{"database":"InterPro","id":"IPR006130","properties":[{"key":"EntryName","value":"Asp/Orn_carbamoylTrfase"}]},{"database":"InterPro","id":"IPR036901","properties":[{"key":"EntryName","value":"Asp/Orn_carbamoylTrfase_sf"}]},{"database":"InterPro","id":"IPR002082","properties":[{"key":"EntryName","value":"Asp_carbamoyltransf"}]},{"database":"InterPro","id":"IPR006131","properties":[{"key":"EntryName","value":"Asp_carbamoyltransf_Asp/Orn-bd"}]},{"database":"InterPro","id":"IPR011761","properties":[{"key":"EntryName","value":"ATP-grasp"}]},{"database":"InterPro","id":"IPR013815","properties":[{"key":"EntryName","value":"ATP_grasp_subdomain_1"}]},{"database":"InterPro","id":"IPR036897","properties":[{"key":"EntryName","value":"CarbamoylP_synth_lsu_oligo_sf"}]},{"database":"InterPro","id":"IPR006274","properties":[{"key":"EntryName","value":"CarbamoylP_synth_ssu"}]},{"database":"InterPro","id":"IPR002474","properties":[{"key":"EntryName","value":"CarbamoylP_synth_ssu_N"}]},{"database":"InterPro","id":"IPR036480","properties":[{"key":"EntryName","value":"CarbP_synth_ssu_N_sf"}]},{"database":"InterPro","id":"IPR029062","properties":[{"key":"EntryName","value":"Class_I_gatase-like"}]},{"database":"InterPro","id":"IPR005479","properties":[{"key":"EntryName","value":"CPAse_ATP-bd"}]},{"database":"InterPro","id":"IPR005483","properties":[{"key":"EntryName","value":"CPSase_dom"}]},{"database":"InterPro","id":"IPR035686","properties":[{"key":"EntryName","value":"CPSase_GATase1"}]},{"database":"InterPro","id":"IPR006275","properties":[{"key":"EntryName","value":"CPSase_lsu"}]},{"database":"InterPro","id":"IPR005480","properties":[{"key":"EntryName","value":"CPSase_lsu_oligo"}]},{"database":"InterPro","id":"IPR058047","properties":[{"key":"EntryName","value":"CPSase_preATP-grasp"}]},{"database":"InterPro","id":"IPR017926","properties":[{"key":"EntryName","value":"GATASE"}]},{"database":"InterPro","id":"IPR032466","properties":[{"key":"EntryName","value":"Metal_Hydrolase"}]},{"database":"InterPro","id":"IPR011607","properties":[{"key":"EntryName","value":"MGS-like_dom"}]},{"database":"InterPro","id":"IPR036914","properties":[{"key":"EntryName","value":"MGS-like_dom_sf"}]},{"database":"InterPro","id":"IPR016185","properties":[{"key":"EntryName","value":"PreATP-grasp_dom_sf"}]},{"database":"NCBIfam","id":"TIGR00670","properties":[{"key":"EntryName","value":"asp_carb_tr"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF003671","properties":[{"key":"EntryName","value":"carB"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01369","properties":[{"key":"EntryName","value":"CPSaseII_lrg"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR01368","properties":[{"key":"EntryName","value":"CPSaseIIsmall"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF002032","properties":[{"key":"EntryName","value":"PRK00856.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF009455","properties":[{"key":"EntryName","value":"PRK12815.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF009475","properties":[{"key":"EntryName","value":"PRK12838.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11405:SF5","properties":[{"key":"EntryName","value":"CAD PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11405","properties":[{"key":"EntryName","value":"CARBAMOYLTRANSFERASE FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25596","properties":[{"key":"EntryName","value":"CPSase_L_D1"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF02786","properties":[{"key":"EntryName","value":"CPSase_L_D2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF02787","properties":[{"key":"EntryName","value":"CPSase_L_D3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00988","properties":[{"key":"EntryName","value":"CPSase_sm_chain"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00117","properties":[{"key":"EntryName","value":"GATase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02142","properties":[{"key":"EntryName","value":"MGS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00185","properties":[{"key":"EntryName","value":"OTCace"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02729","properties":[{"key":"EntryName","value":"OTCace_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00100","properties":[{"key":"EntryName","value":"AOTCASE"}]},{"database":"PRINTS","id":"PR00101","properties":[{"key":"EntryName","value":"ATCASE"}]},{"database":"PRINTS","id":"PR00098","properties":[{"key":"EntryName","value":"CPSASE"}]},{"database":"PRINTS","id":"PR00099","properties":[{"key":"EntryName","value":"CPSGATASE"}]},{"database":"SMART","id":"SM01096","properties":[{"key":"EntryName","value":"CPSase_L_D3"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01097","properties":[{"key":"EntryName","value":"CPSase_sm_chain"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00851","properties":[{"key":"EntryName","value":"MGS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53671","properties":[{"key":"EntryName","value":"Aspartate/ornithine carbamoyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48108","properties":[{"key":"EntryName","value":"Carbamoyl phosphate synthetase, large subunit connection domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52021","properties":[{"key":"EntryName","value":"Carbamoyl phosphate synthetase, small subunit N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52317","properties":[{"key":"EntryName","value":"Class I glutamine amidotransferase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56059","properties":[{"key":"EntryName","value":"Glutathione synthetase ATP-binding domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF51556","properties":[{"key":"EntryName","value":"Metallo-dependent hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52335","properties":[{"key":"EntryName","value":"Methylglyoxal synthase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52440","properties":[{"key":"EntryName","value":"PreATP-grasp domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50975","properties":[{"key":"EntryName","value":"ATP_GRASP"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00097","properties":[{"key":"EntryName","value":"CARBAMOYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00866","properties":[{"key":"EntryName","value":"CPSASE_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00867","properties":[{"key":"EntryName","value":"CPSASE_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51273","properties":[{"key":"EntryName","value":"GATASE_TYPE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51855","properties":[{"key":"EntryName","value":"MGS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSGLNVNSQGAAAPTAISPSLRSALADQVPSRTPSPALPATSAPVGTPAAPPMVLELADGTEYQGLSFGAEGKSISGECVFQTGMVGYVESLTDPSYEGQILVLTYPLIGNYGVPARPQGAEIPKLKAPFESTRIHVAGLVVASYSHDFSHYLAASGLSDWLKENGVPAVYGIDTRALTKRIRTKGSMLARLLAPRPDAPLDGPWQQRMLEVPWHDPNGENLVAKVSRKQAELYTPQDTQPAGLRTANGPSLLHASGRPLRVLALDMGMKLNQIRCFTSRGVELKVVPFDYDFLHESEPFDGLFISNGPGDPTQCMATVERIRALLSRTDDVIPVFGICLGHQLLALAAGARTIKMKYGNRGQNIPCTDQLSGRCYITSQNHGYAVDSTSLPSGWAELFVNANDSTNEGIYCEHAPFFSVQFHPESTAGPRDTEYLFDVFVRSVVDNAAVRHASGGAMLAQGPTSFPGGTLAENEAATPRLHPRKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTVLINPNIATIQTSAGLADKVYFLPVTPEFVLKVLRHERPDGIYCTFGGQTALNVGIQIKDELAPLGVRNLGTPIDTIIKTEDRDLFARAMEEINERCAPSASANTWDEALTAARTIGFPVIVRAAFALGGLGSGFAKNEDELRRLCHTAFANSPQVLVEKSMKGWKEIEYEVVRDCRNNCITVCNMENFDPLGVHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPESKEYCIIEVNARLSRSSALASKATGYPLAFVAAKLGLNIPLNELRNSVTRETSACFEPSLDYIVTKMPRWDLRKFMRVSSKLGSSMKSVGEVMSIGRTFEESLQKAIRSVDPSFEGFGRNDHVELTDLDEELERPTDRRIFAIANAMAQGYSVERLHQLSSIDRWFLHKLQGIMNVAKAMESSSAATIPAALLRQAKQVGFSDRQIAKCSSSAELAVRRRRQELGIMPFVKQIDTVAAEFPAQTNYLYTTYNAVEHDLTFNDKGVMVLGSGVYRIGSSVEFDWCAVRAIRTLRAQGYKTVMVNYNPETVSTDYDEADRLYFENISLETVMDIYELEQSSGVVISMGGQIPNNIALPLHRQGVKVLGTSPEMIDNAENRYKFSRMLDRLGVDQPMWKELSSLEDAYSACARFGYPVLVRPSYVLSGAAMNVVYSAEDLSNYLSQAAAINREHPVVITKYLEGAKEIEMDAVAKDGKLIMHYISEHVENAGVHSGDATLILPPQDLEPETVRRIEDATSKIVEALNVTGPCNIQFIAKNNEIKVIECNVRAARSFPFVSKVTGVDAIEMATCAMMGLPVSPYPKVELPKEYVGIKVPQFSFSRLSGADPILGVEMASTGEVACFGRNKYEAYLRAMLASGIRLPTNNVLLSVGSFSEKQELLPSVRTLHGLGFTLYGSSGTADFYTEHGIPVVHLEALPEDDDWRSDDNSKASYSLLTHLTQGLSSLFISLPSKNKYRRPSSFTSMGYRARRLAIDRSIPLLTNVKNAKLFVEALAMHRRQGSQFEILPIDAKTSHITCQFPGLVGAPAMIPTLGALDKANVAAYTRAAAQAGFTSLVLHPVGKAGAIVDVASLTAAESALEGQCAVDVSLTLLATPEHVEQFEQLAPRVRALFVSYHGSAREASLRPAMVASYFAHWPEDKPIVTDAAGAELASVLLLASLHNRPIHVTNVRTRDDLQLIALSKAKGLHVTCDVPVYALFFASDRYPAASCLPSAEDQAALWQSLDEIDVFSLGTMPCQLAEQLGHAAPSTAGLDEAMHLLLNAVNENRLTVEVVQERLCTHPRAIFQLPEQMDTLVSAEVDRVVRDVARSGWSPLDTASCHGAVERVQLRGKTIVLDGNSLMERAIGANISALTSAKPVELKSTLEPVPMSPVAMRSPRRRGTNVRSLTSMDDFRMEPAMAPELGPAPPTRIPLYHPSFARRHILSVRQFSRDDLHALFAVAQELRFLVERQGVLDILRGRVMSTLFYEESTRTSSSFEAAMLRAGGQVVTINTSRSSVAKGETLADTVRTLGCYSDVIVLRHPAVGSSQEAAKFSPVPIMNAGDGVGEHPTQALLDVFTIREELGTVNGLTVTLLGDLKNGRTTHSLVRLLSLYGVAVNFVSPPSLAMPREVVREVSKQGISIYETSNLDEVLYKTDVLYVTRIQRERFASPDEYEAVKGSYVINNDVLARAKADMVVLHPLPRVDEIDPEVDFDIKRAAYFRQMRCGLFIRMALLAMTLQSSDRS","length":2269,"molWeight":247678,"crc64":"5C782205D87E1871","md5":"CAE558F739B3D0ABD0995385A84D9F97"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":4,"COFACTOR":1,"PATHWAY":2,"SIMILARITY":4},"countByFeatureType":{"Domain":3,"Region":1,"Compositional bias":1,"Active site":3},"uniParcId":"UPI00279ABB47"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EBP9","uniProtkbId":"A0AAF0EBP9_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":12,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21590.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012629"}],"value":"tRNA (cytosine(34)-C(5))-methyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012629"}],"value":"2.1.1.203"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032770"}],"value":"NOL1/NOP2/Sun domain family member 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032819"}],"value":"mRNA cytosine C(5)-methyltransferase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032179"}],"value":"tRNA cytosine C(5)-methyltransferase"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21590.1"}],"value":"NCL1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21590.1"}],"value":"MEQU1_000243"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:61464"},{"database":"Rhea","id":"RHEA-COMP:15145"},{"database":"Rhea","id":"RHEA-COMP:15826"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:74483"},{"database":"ChEBI","id":"CHEBI:82748"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049365"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:61465"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049365"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:42940"},{"database":"Rhea","id":"RHEA-COMP:10291"},{"database":"Rhea","id":"RHEA-COMP:10295"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:74483"},{"database":"ChEBI","id":"CHEBI:82748"}],"ecNumber":"2.1.1.203","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049286"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:42941"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049286"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:42948"},{"database":"Rhea","id":"RHEA-COMP:10293"},{"database":"Rhea","id":"RHEA-COMP:10297"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:74483"},{"database":"ChEBI","id":"CHEBI:82748"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049323"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:42949"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049323"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:42952"},{"database":"Rhea","id":"RHEA-COMP:10294"},{"database":"Rhea","id":"RHEA-COMP:10385"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:74483"},{"database":"ChEBI","id":"CHEBI:82748"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048755"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:42953"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048755"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:61488"},{"database":"Rhea","id":"RHEA-COMP:15838"},{"database":"Rhea","id":"RHEA-COMP:15839"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:74483"},{"database":"ChEBI","id":"CHEBI:82748"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048936"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:61489"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048936"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004186"}],"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004604"}],"value":"Nucleus, nucleolus","id":"SL-0188"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004550"}],"value":"Secreted, extracellular exosome","id":"SL-0466"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}],"value":"Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":468,"modifier":"EXACT"}},"description":"SAM-dependent MTase RsmB/NOP-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51686"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":793,"modifier":"EXACT"},"end":{"value":830,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":499,"modifier":"EXACT"},"end":{"value":549,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":817,"modifier":"EXACT"},"end":{"value":830,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":325,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}]},{"type":"Binding site","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022603"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}],"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022884"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}],"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022691"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}],"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01023"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022694"}],"id":"KW-0819","category":"Biological process","name":"tRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022555"}],"id":"KW-0820","category":"Molecular function","name":"tRNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21590.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21590.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD21590.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0EBP9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016428","properties":[{"key":"GoTerm","value":"F:tRNA (cytidine-N5)-methyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0000049","properties":[{"key":"GoTerm","value":"F:tRNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030488","properties":[{"key":"GoTerm","value":"P:tRNA methylation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"3.40.50.150:FF:000075","properties":[{"key":"EntryName","value":"NOP2/Sun RNA methyltransferase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR049560","properties":[{"key":"EntryName","value":"MeTrfase_RsmB-F_NOP2_cat"}]},{"database":"InterPro","id":"IPR001678","properties":[{"key":"EntryName","value":"MeTrfase_RsmB-F_NOP2_dom"}]},{"database":"InterPro","id":"IPR057285","properties":[{"key":"EntryName","value":"Pre-PUA_NSUN2"}]},{"database":"InterPro","id":"IPR057286","properties":[{"key":"EntryName","value":"PUA_NSUN2"}]},{"database":"InterPro","id":"IPR023267","properties":[{"key":"EntryName","value":"RCMT"}]},{"database":"InterPro","id":"IPR023270","properties":[{"key":"EntryName","value":"RCMT_NCL1"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"PANTHER","id":"PTHR22808","properties":[{"key":"EntryName","value":"NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22808:SF1","properties":[{"key":"EntryName","value":"RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01189","properties":[{"key":"EntryName","value":"Methyltr_RsmB-F"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25376","properties":[{"key":"EntryName","value":"Pre-PUA_NSUN2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25378","properties":[{"key":"EntryName","value":"PUA_NSUN2"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR02008","properties":[{"key":"EntryName","value":"RCMTFAMILY"}]},{"database":"PRINTS","id":"PR02011","properties":[{"key":"EntryName","value":"RCMTNCL1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51686","properties":[{"key":"EntryName","value":"SAM_MT_RSMB_NOP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGRGRAYRRGHGRGKAPGRSSGGERRADYATFEQTSPKFESYYQGQGILPADEWAPFLAAMRAPLPTTFRITSGKPTARQLLDAMKNIYVPFLSNVEFEGEKVTPPTQLPWYPEGLGWHLDVRKNVLRKSPEFKRFQQFLVHETEVGSISRQEAVSMLPPLFLDVQPEHLVLDMCAAPGSKTAQLIEAIHSPLTSEPDAFDPMPQGVVVANDSDTKRAHMLVHQAQRLPSPNLCVTNVDASNMANIQVAWKGEAPTDKIRMRDLKYDRILADVPCSGDGTLRKNLAIWKDWTPMNGVGLHALQLRILIRGLTLLRPGGRLVYSTCSLNPIENEAVVAAALRHFQGDVEIVDCADMVPALQRRPGMTHWKVVPGKGQHLAQATKTPESEQSHSHETKAEGQTEEKTLPPMPWVESYEALQSVDADLASRTPTSLWPQGDEEALHMERCIRVYPHLQNTGGFFVTVLTKKSTTPDESVSMAPGMIRAMDAMSAGDIPVSKRPADEEGPTEAKRVKSEAKAEAEPEAEPAKEDALPPVDKHRADREAKRRGQPEGVAIGAGGMPYREDPFAYVDPANADVQSCVEWFGLHHFPTANLLVRNPERVPLRSVYLTSNTVRAIVSGGGPGMGVHPTMNPLKVRLLNCGVKVFGRQESVSKATQAPNAMDVSGDAAVRRENVSAALACRWRVVSDSLHSMRPYLSEKVVIKATLADLAFFIKEYYPVLDKIPGEVGERIRQADMGSYVLDIEPSEHNGHQLTVRLCYPVWRSVASANLMLDKQEKSALSFRLFDTDLSDPEGQRQFSMHPQARKKQAELQAQKAQEESNEGRSEATA","length":830,"molWeight":91743,"crc64":"1A78CDD843C02EE3","md5":"797E24F72A174A68D6C857D7A0B07B70"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":5,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":4,"Compositional bias":4,"Active site":1,"Binding site":4},"uniParcId":"UPI0027AB457B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0ECU3","uniProtkbId":"A0AAF0ECU3_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":11,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22190.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"Sulfate adenylyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"2.7.7.4"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"ATP-sulfurylase"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"Sulfate adenylate transferase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"SAT"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22190.1"}],"value":"MET3"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22190.1"}],"value":"MEQU1_000854"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:24152"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:58243"},{"database":"ChEBI","id":"CHEBI:58339"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.25","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001823"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:18133"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16189"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:58243"}],"ecNumber":"2.7.7.4","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00062002"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"Homohexamer. Dimer of trimers"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"In the C-terminal section; belongs to the APS kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"In the N-terminal section; belongs to the sulfate adenylyltransferase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"ATP-sulfurylase PUA-like","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF14306"}]},{"type":"Domain","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"Sulphate adenylyltransferase catalytic","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01747"}]},{"type":"Domain","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":551,"modifier":"EXACT"}},"description":"APS kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF01583"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"N-terminal","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}]},{"type":"Region","location":{"start":{"value":396,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"Allosteric regulation domain; adenylyl-sulfate kinase-like","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}]},{"type":"Active site","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}]},{"type":"Active site","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}]},{"type":"Active site","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}]},{"type":"Binding site","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16189"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"ligand":{"name":"sulfate","id":"ChEBI:CHEBI:16189"}},{"type":"Binding site","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16189"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"ligand":{"name":"sulfate","id":"ChEBI:CHEBI:16189"}},{"type":"Binding site","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:16189"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"ligand":{"name":"sulfate","id":"ChEBI:CHEBI:16189"}},{"type":"Binding site","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58339"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"ligand":{"name":"3'-phosphoadenylyl sulfate","id":"ChEBI:CHEBI:58339","note":"allosteric inhibitor"}},{"type":"Binding site","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58339"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"ligand":{"name":"3'-phosphoadenylyl sulfate","id":"ChEBI:CHEBI:58339","note":"allosteric inhibitor"}},{"type":"Site","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}]},{"type":"Site","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}]},{"type":"Site","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Induces change in substrate recognition on ATP binding","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022533"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"id":"KW-0021","category":"Molecular function","name":"Allosteric enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"id":"KW-0198","category":"Biological process","name":"Cysteine biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"id":"KW-0486","category":"Biological process","name":"Methionine biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03106"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22190.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22190.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119901","properties":[{"key":"ProteinId","value":"WFD22190.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0ECU3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004020","properties":[{"key":"GoTerm","value":"F:adenylylsulfate kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004781","properties":[{"key":"GoTerm","value":"F:sulfate adenylyltransferase (ATP) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0070814","properties":[{"key":"GoTerm","value":"P:hydrogen sulfide biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000103","properties":[{"key":"GoTerm","value":"P:sulfate assimilation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd02027","properties":[{"key":"EntryName","value":"APSK"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00517","properties":[{"key":"EntryName","value":"ATPS"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.400.10:FF:000003","properties":[{"key":"EntryName","value":"Sulfate adenylyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000802","properties":[{"key":"EntryName","value":"Sulfate adenylyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.620:FF:000052","properties":[{"key":"EntryName","value":"Sulfate adenylyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.620","properties":[{"key":"EntryName","value":"HUPs"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.400.10","properties":[{"key":"EntryName","value":"Sulfate adenylyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03106","properties":[{"key":"EntryName","value":"Sulf_adenylyltr_euk"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002891","properties":[{"key":"EntryName","value":"APS"}]},{"database":"InterPro","id":"IPR059117","properties":[{"key":"EntryName","value":"APS_kinase_dom"}]},{"database":"InterPro","id":"IPR025980","properties":[{"key":"EntryName","value":"ATP-Sase_PUA-like_dom"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR015947","properties":[{"key":"EntryName","value":"PUA-like_sf"}]},{"database":"InterPro","id":"IPR014729","properties":[{"key":"EntryName","value":"Rossmann-like_a/b/a_fold"}]},{"database":"InterPro","id":"IPR027535","properties":[{"key":"EntryName","value":"Sulf_adenylyltr_euk"}]},{"database":"InterPro","id":"IPR050512","properties":[{"key":"EntryName","value":"Sulf_AdTrans/APS_kinase"}]},{"database":"InterPro","id":"IPR024951","properties":[{"key":"EntryName","value":"Sulfurylase_cat_dom"}]},{"database":"InterPro","id":"IPR002650","properties":[{"key":"EntryName","value":"Sulphate_adenylyltransferase"}]},{"database":"NCBIfam","id":"TIGR00455","properties":[{"key":"EntryName","value":"apsK"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF004040","properties":[{"key":"EntryName","value":"PRK05537.1"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR00339","properties":[{"key":"EntryName","value":"sopT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42700","properties":[{"key":"EntryName","value":"SULFATE ADENYLYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR42700:SF1","properties":[{"key":"EntryName","value":"SULFATE ADENYLYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01583","properties":[{"key":"EntryName","value":"APS_kinase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01747","properties":[{"key":"EntryName","value":"ATP-sulfurylase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14306","properties":[{"key":"EntryName","value":"PUA_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52374","properties":[{"key":"EntryName","value":"Nucleotidylyl transferase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF88697","properties":[{"key":"EntryName","value":"PUA domain-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVNPPHGGVLKDLLARDASKAAALEEEANSLSDLVLSERQLCDLELIITGGFSPLEGFMGQADYEGCLTNMRLADGTLFPMPITLDVSKEQVSSLGLQAGSRIALRDPRDDNAIAILTVSDLHDVNRSREAELVLGADDKAHPAVAYLYTQVKDVYVGGTVEAIRKPQYYDYVELRFTPAELRHHFEKVAWRKVVAFQTRNPMHRAHRELTVRAARQLQANILIHPVVGMTKPGDVDHYTRVRVYSSLMPRYPKGMATLALLPLAMRMAGPREALWHAIIRKNFGVSHFIVGRDHAGPGKNSKGQDFYGPYDAQDLVRKHTDELGIEMVPFQQMTYLPDSDEYQPVDEVQPGTRTLDISGTELRKRLRTGAPIPDWFSYESVVKTLRESYPPKTSQGFTLFLTGLYNSGKDQIARALQVKLHEQGGRSVSLLLGETVRSELSSELGFSPEDRHTNIQRIAFVASELTRAGAAVIAAPIAPYENSRAMARETVQKNGGSGNFFLVHVATPLEYCEKTDRRGNYAKARRGEIKGFTGVDDHYEEPKDVDLKVDPSQQSIAEITHSIVLLLEANGLI","length":574,"molWeight":63771,"crc64":"47FC5F2C4B29A677","md5":"33C0383D4FB12F50080D1A37F630E847"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"ACTIVITY REGULATION":1,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":2,"CAUTION":1},"countByFeatureType":{"Domain":3,"Region":2,"Active site":3,"Binding site":8,"Site":3},"uniParcId":"UPI0027A57591"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EDE9","uniProtkbId":"A0AAF0EDE9_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":12,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22934.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012551"}],"value":"DNA helicase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012551"}],"value":"3.6.4.12"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00078187"}],"value":"Minichromosome maintenance protein 3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22934.1"}],"value":"MCM3"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22934.1"}],"value":"MEQU1_001615"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.12","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047995"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037868"}],"value":"Endomembrane system","id":"SL-0147"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037868"}],"value":"Lipid-anchor","id":"SL-9901"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008010"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"value":"Belongs to the MCM family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006270"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"value":"Belongs to the small GTPase superfamily. Rab family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":673,"modifier":"EXACT"}},"description":"MCM C-terminal AAA(+) ATPase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50051"}]},{"type":"Region","location":{"start":{"value":675,"modifier":"EXACT"},"end":{"value":743,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":852,"modifier":"EXACT"},"end":{"value":860,"modifier":"EXACT"}},"description":"Switch-I","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Region","location":{"start":{"value":883,"modifier":"EXACT"},"end":{"value":899,"modifier":"EXACT"}},"description":"Switch-II","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}]},{"type":"Region","location":{"start":{"value":1005,"modifier":"EXACT"},"end":{"value":1028,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Walker A","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}]},{"type":"Motif","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"Walker B","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}]},{"type":"Compositional bias","location":{"start":{"value":689,"modifier":"EXACT"},"end":{"value":708,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":715,"modifier":"EXACT"},"end":{"value":728,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1008,"modifier":"EXACT"},"end":{"value":1019,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Arginine finger","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022806"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22934.1"}],"id":"KW-0347","category":"Molecular function","name":"Helicase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22934.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00753"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023289"}],"id":"KW-0636","category":"PTM","name":"Prenylation"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22934.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22934.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119902","properties":[{"key":"ProteinId","value":"WFD22934.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0EDE9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031410","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0031261","properties":[{"key":"GoTerm","value":"C:DNA replication preinitiation complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0042555","properties":[{"key":"GoTerm","value":"C:MCM complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005656","properties":[{"key":"GoTerm","value":"C:nuclear pre-replicative complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0043596","properties":[{"key":"GoTerm","value":"C:nuclear replication fork"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003697","properties":[{"key":"GoTerm","value":"F:single-stranded DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0017116","properties":[{"key":"GoTerm","value":"F:single-stranded DNA helicase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006271","properties":[{"key":"GoTerm","value":"P:DNA strand elongation involved in DNA replication"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000727","properties":[{"key":"GoTerm","value":"P:double-strand break repair via break-induced replication"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1902975","properties":[{"key":"GoTerm","value":"P:mitotic DNA replication initiation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006279","properties":[{"key":"GoTerm","value":"P:premeiotic DNA replication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd01868","properties":[{"key":"EntryName","value":"Rab11_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.20.28.10:FF:000008","properties":[{"key":"EntryName","value":"DNA helicase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000234","properties":[{"key":"EntryName","value":"DNA helicase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000085","properties":[{"key":"EntryName","value":"Putative ras-related protein rab-11a"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.28.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1640.10","properties":[{"key":"EntryName","value":"mini-chromosome maintenance (MCM) complex, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR031327","properties":[{"key":"EntryName","value":"MCM"}]},{"database":"InterPro","id":"IPR018525","properties":[{"key":"EntryName","value":"MCM_CS"}]},{"database":"InterPro","id":"IPR001208","properties":[{"key":"EntryName","value":"MCM_dom"}]},{"database":"InterPro","id":"IPR041562","properties":[{"key":"EntryName","value":"MCM_lid"}]},{"database":"InterPro","id":"IPR027925","properties":[{"key":"EntryName","value":"MCM_N"}]},{"database":"InterPro","id":"IPR033762","properties":[{"key":"EntryName","value":"MCM_OB"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR005225","properties":[{"key":"EntryName","value":"Small_GTP-bd"}]},{"database":"InterPro","id":"IPR001806","properties":[{"key":"EntryName","value":"Small_GTPase"}]},{"database":"InterPro","id":"IPR056575","properties":[{"key":"EntryName","value":"WH_MCM3_C"}]},{"database":"NCBIfam","id":"TIGR00231","properties":[{"key":"EntryName","value":"small_GTP"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11630","properties":[{"key":"EntryName","value":"DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11630:SF46","properties":[{"key":"EntryName","value":"DNA REPLICATION LICENSING FACTOR MCM3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00493","properties":[{"key":"EntryName","value":"MCM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17855","properties":[{"key":"EntryName","value":"MCM_lid"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14551","properties":[{"key":"EntryName","value":"MCM_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17207","properties":[{"key":"EntryName","value":"MCM_OB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00071","properties":[{"key":"EntryName","value":"Ras"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23191","properties":[{"key":"EntryName","value":"WHD_MCM3_C"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00449","properties":[{"key":"EntryName","value":"RASTRNSFRMNG"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00350","properties":[{"key":"EntryName","value":"MCM"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00175","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00176","properties":[{"key":"EntryName","value":"RAN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00173","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00174","properties":[{"key":"EntryName","value":"RHO"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00847","properties":[{"key":"EntryName","value":"MCM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50051","properties":[{"key":"EntryName","value":"MCM_CTD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51419","properties":[{"key":"EntryName","value":"RAB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51421","properties":[{"key":"EntryName","value":"RAS"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51420","properties":[{"key":"EntryName","value":"RHO"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAEGMALDVPALDDDLYRDRTRTFAEFLDDQSGATDYRSAIRRMIAADERRLIVNVDDLRAYNREYATGLLDEPNDYLPPFEHALQALVEQLHDPLKDDIQGKLFHIGVRGSFGDNHVSTRMLRSTHLGKLMSLEGIVTRCSLVRPKIVKSVHYCDATSRFHMREYRDATMYGSGPPTSSTYPTTDESGNRLTTEYGLCTFRDHQMISIQEMPERAPPGQLPRSVDVVMDDDLVDKVKPGDRIQLVGMYKSLGNRVGQSTTSTFRTLMVGNYVFVLSNKAGGGISQMPLSDLDIRNINKISRRRGVFDLLAESLAPSIFGHEYLKKAVLLMLLGGQEKNLPNGTHIRGDINILMVGDPSTAKSQMLRFVLNMAPLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMSDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPIYGQYDVHKEPGRNIALPDSLLSRFDLLFVITDDIDEVRDRRISEHVLRMHRYVQPGQPVGVPAKDSLDQVLDVGGASEAPQPAEAPEDESPFERYNPLLHVGVDSNRAEVLSMTFLKKYLQYAKSRVAPVLSPGAAAWISNVYANLRNDEQGGNVRRTAPLTARTLETLIRLATAYAKARLSATVEEQDAEAAEALLRYALFKEVMKPSRSKRQRTTRAGSQESDEDDDDMAWDEEHEDQDEADRQLGGQPSTARAPTSTYGTRAATRAAEQSADVTQAPAVPMSELQAFRARVAQALSSTFADDEFVELPALLQAVNAAGPPFEMEVARAALDAMSEANQIMLADEAAMAAESNYDYLFKVVLIGDSGTGKSNLLSRFTRNEFSLDSRSTIGVEFATRSINVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHSTYVNVSRWLKELRDHADSNIVVMLVGNKSDLKHLRAVPTEEAKAFAAENNLSFIETSALDASNVEQAFQNILTEIYHIVSNKALQSSDDVIKPSGGETISVQPSTDDGGQTKKGGCC","length":1028,"molWeight":112994,"crc64":"1DE7BCC2D6CC411D","md5":"E68C35E155339D09BE5B9E8BEF02F696"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2},"countByFeatureType":{"Domain":1,"Region":4,"Motif":2,"Compositional bias":3,"Site":1},"uniParcId":"UPI0027A0D6AB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EFM8","uniProtkbId":"A0AAF0EFM8_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":10,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD24149.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"}},"includes":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Glutamate N-acetyltransferase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"GAT"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"2.3.1.35"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Ornithine acetyltransferase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"OATase"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Ornithine transacetylase"}}]},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Amino-acid acetyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"2.3.1.1"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"N-acetylglutamate synthase"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"AGS"}]}]}],"contains":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Arginine biosynthesis bifunctional protein ArgJ alpha chain"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Arginine biosynthesis bifunctional protein ArgJ beta chain"}}}]},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD24149.1"}],"value":"MEQU1_002846"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:24292"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:44337"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"}],"ecNumber":"2.3.1.1","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15349"},{"database":"ChEBI","id":"CHEBI:29985"},{"database":"ChEBI","id":"CHEBI:44337"},{"database":"ChEBI","id":"CHEBI:46911"},{"database":"ChEBI","id":"CHEBI:57805"}],"ecNumber":"2.3.1.35","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Heterodimer of an alpha and a beta chain"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Mitochondrion matrix","id":"SL-0170"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006774"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Belongs to the ArgJ family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Arginine biosynthesis bifunctional protein ArgJ alpha chain","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"featureId":"PRO_5041753454"},{"type":"Chain","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"Arginine biosynthesis bifunctional protein ArgJ beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"featureId":"PRO_5041753453"},{"type":"Active site","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}]},{"type":"Binding site","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"ligand":{"name":"substrate"}},{"type":"Binding site","location":{"start":{"value":479,"modifier":"EXACT"},"end":{"value":479,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"ligand":{"name":"substrate"}},{"type":"Site","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}]},{"type":"Site","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}]},{"type":"Site","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Cleavage; by autolysis","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023315"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022605"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"id":"KW-0028","category":"Biological process","name":"Amino-acid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022571"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"id":"KW-0055","category":"Biological process","name":"Arginine biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022813"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"id":"KW-0068","category":"PTM","name":"Autocatalytic cleavage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03124"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD24149.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD24149.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119904","properties":[{"key":"ProteinId","value":"WFD24149.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0EFM8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004042","properties":[{"key":"GoTerm","value":"F:L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004358","properties":[{"key":"GoTerm","value":"F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006526","properties":[{"key":"GoTerm","value":"P:L-arginine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006592","properties":[{"key":"GoTerm","value":"P:L-ornithine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd02152","properties":[{"key":"EntryName","value":"OAT"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.10.20.340:FF:000002","properties":[{"key":"EntryName","value":"Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.60.70.12:FF:000006","properties":[{"key":"EntryName","value":"Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.2330.10","properties":[{"key":"EntryName","value":"arginine biosynthesis bifunctional protein suprefamily"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.20.340","properties":[{"key":"EntryName","value":"ArgJ beta chain, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.60.70.12","properties":[{"key":"EntryName","value":"L-amino peptidase D-ALA esterase/amidase"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01106","properties":[{"key":"EntryName","value":"ArgJ"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002813","properties":[{"key":"EntryName","value":"Arg_biosynth_ArgJ"}]},{"database":"InterPro","id":"IPR016117","properties":[{"key":"EntryName","value":"ArgJ-like_dom_sf"}]},{"database":"InterPro","id":"IPR042195","properties":[{"key":"EntryName","value":"ArgJ_beta_C"}]},{"database":"NCBIfam","id":"NF003802","properties":[{"key":"EntryName","value":"argJ"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"TIGR00120","properties":[{"key":"EntryName","value":"ArgJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23100","properties":[{"key":"EntryName","value":"ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23100:SF0","properties":[{"key":"EntryName","value":"ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01960","properties":[{"key":"EntryName","value":"ArgJ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56266","properties":[{"key":"EntryName","value":"DmpA/ArgJ-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHSTMSKAERFVVPVDRNTLPRGYLVATTYAGIKKAISPAPTTASAPQQAPKPDLTLLVSSTPASVAGTFTSNKFQAAPVVHATKALQAQGPHARARAVLVNSGCANAVTGQGGCEDTETLVKEVQKLLPAGKQSSSDMPSDVLMMSTGVIGVRLPVPQMLRGIQHLMRGHILQSNPDAWLEMARAFMTTDTFPKLRTRQFTLGNRLCSIAAIDKGAGMIHPHMTSPGGLHATLLGLFVTDAPVATPTLQRCLEEAVRQSFNCISVDGDMSTNDTILALANGQAPVIGQGTSVEGNMSEETHPDLVKIFADELKAMSVEMAHLIVRDGEGAEKFVQVRVKNAGTYEQAHAIASSISTSALVKCAMHGEDANWGRILCAAGYAAVPTSSPAWSLDPSKVNVTFVPPPNARNLSPIQTLKNGVPQPVDEAKAAELLSHEDIYIDMDLQGGSWTEGACAEAVFWTCDFSKEYISVRCACSHTDQW","length":482,"molWeight":51342,"crc64":"71038DFC5CA366B8","md5":"FC8DC519B9D96BD9E06C9459AC9A7301"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"PATHWAY":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"PTM":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Chain":2,"Active site":1,"Binding site":5,"Site":3},"uniParcId":"UPI00279AEE9C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EFW8","uniProtkbId":"A0AAF0EFW8_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":12,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD24694.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00068515"}],"value":"L-lactate dehydrogenase (cytochrome)"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00066458"}],"value":"1.1.2.3"}]}},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD24694.1"}],"value":"MEQU1_003397"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:19909"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15361"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16651"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.1.2.3","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052399"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:19910"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052399"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"FMN","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001917"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58210"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"heme b","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001970"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:60344"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011881"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004569"}],"value":"Mitochondrion intermembrane space","id":"SL-0169"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"value":"Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005804"}],"value":"Belongs to the G-alpha family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061137"}],"value":"In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00061589"}],"value":"In the N-terminal section; belongs to the cytochrome b5 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00279"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"Cytochrome b5 heme-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50255"}]},{"type":"Domain","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"FMN hydroxy acid dehydrogenase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51349"}]},{"type":"Region","location":{"start":{"value":511,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"G1 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Region","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"G2 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Region","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"G3 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Region","location":{"start":{"value":734,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"G4 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Region","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"G5 motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}]},{"type":"Active site","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}]},{"type":"Binding site","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:35179"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"ligand":{"name":"a 2-oxocarboxylate","id":"ChEBI:CHEBI:35179"}},{"type":"Binding site","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58210"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"ligand":{"name":"FMN","id":"ChEBI:CHEBI:58210"}},{"type":"Binding site","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:35179"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"ligand":{"name":"a 2-oxocarboxylate","id":"ChEBI:CHEBI:35179"}},{"type":"Binding site","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58210"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"ligand":{"name":"FMN","id":"ChEBI:CHEBI:58210"}},{"type":"Binding site","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:35179"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"ligand":{"name":"a 2-oxocarboxylate","id":"ChEBI:CHEBI:35179"}},{"type":"Binding site","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58210"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"ligand":{"name":"FMN","id":"ChEBI:CHEBI:58210"}},{"type":"Binding site","location":{"start":{"value":366,"modifier":"EXACT"},"end":{"value":366,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:35179"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"ligand":{"name":"a 2-oxocarboxylate","id":"ChEBI:CHEBI:35179"}},{"type":"Binding site","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58210"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"ligand":{"name":"FMN","id":"ChEBI:CHEBI:58210"}},{"type":"Binding site","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58210"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"ligand":{"name":"FMN","id":"ChEBI:CHEBI:58210"}},{"type":"Binding site","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240"}},{"type":"Binding site","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-2"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60240"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}],"ligand":{"name":"a divalent metal cation","id":"ChEBI:CHEBI:60240"}},{"type":"Binding site","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":738,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}},{"type":"Binding site","location":{"start":{"value":793,"modifier":"EXACT"},"end":{"value":793,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:37565"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"ligand":{"name":"GTP","id":"ChEBI:CHEBI:37565"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022630"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"id":"KW-0285","category":"Ligand","name":"Flavoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022643"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00683"}],"id":"KW-0288","category":"Ligand","name":"FMN"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023288"}],"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-2"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-2"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022707"}],"id":"KW-0519","category":"PTM","name":"Myristate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601019-1"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD24694.1"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023139"}],"id":"KW-0564","category":"PTM","name":"Palmitate"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01230"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD24694.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD24694.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119906","properties":[{"key":"ProteinId","value":"WFD24694.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0EFW8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"GO","id":"GO:0005834","properties":[{"key":"GoTerm","value":"C:heterotrimeric G-protein complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005758","properties":[{"key":"GoTerm","value":"C:mitochondrial intermembrane space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0001664","properties":[{"key":"GoTerm","value":"F:G protein-coupled receptor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0031683","properties":[{"key":"GoTerm","value":"F:G-protein beta/gamma-subunit complex binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004460","properties":[{"key":"GoTerm","value":"F:L-lactate dehydrogenase (cytochrome) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007189","properties":[{"key":"GoTerm","value":"P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0010255","properties":[{"key":"GoTerm","value":"P:glucose mediated signaling pathway"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006089","properties":[{"key":"GoTerm","value":"P:lactate metabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd02922","properties":[{"key":"EntryName","value":"FCB2_FMN"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00066","properties":[{"key":"EntryName","value":"G-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.20.20.70:FF:000062","properties":[{"key":"EntryName","value":"Cytochrome b2, mitochondrial, putative"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000181","properties":[{"key":"EntryName","value":"Guanine nucleotide-binding protein subunit alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000692","properties":[{"key":"EntryName","value":"Guanine nucleotide-binding protein subunit alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.10.120.10","properties":[{"key":"EntryName","value":"Cytochrome b5-like heme/steroid binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.400.10","properties":[{"key":"EntryName","value":"GI Alpha 1, domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"InterPro","id":"IPR001199","properties":[{"key":"EntryName","value":"Cyt_B5-like_heme/steroid-bd"}]},{"database":"InterPro","id":"IPR036400","properties":[{"key":"EntryName","value":"Cyt_B5-like_heme/steroid_sf"}]},{"database":"InterPro","id":"IPR018506","properties":[{"key":"EntryName","value":"Cyt_B5_heme-BS"}]},{"database":"InterPro","id":"IPR000262","properties":[{"key":"EntryName","value":"FMN-dep_DH"}]},{"database":"InterPro","id":"IPR037396","properties":[{"key":"EntryName","value":"FMN_HAD"}]},{"database":"InterPro","id":"IPR008259","properties":[{"key":"EntryName","value":"FMN_hydac_DH_AS"}]},{"database":"InterPro","id":"IPR002975","properties":[{"key":"EntryName","value":"Fungi_Gprotein_alpha"}]},{"database":"InterPro","id":"IPR001019","properties":[{"key":"EntryName","value":"Gprotein_alpha_su"}]},{"database":"InterPro","id":"IPR011025","properties":[{"key":"EntryName","value":"GproteinA_insert"}]},{"database":"InterPro","id":"IPR037458","properties":[{"key":"EntryName","value":"L-MDH/L-LDH_FMN-bd"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR10578:SF148","properties":[{"key":"EntryName","value":"L-LACTATE DEHYDROGENASE (CYTOCHROME)"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10578","properties":[{"key":"EntryName","value":"S -2-HYDROXY-ACID OXIDASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00173","properties":[{"key":"EntryName","value":"Cyt-b5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01070","properties":[{"key":"EntryName","value":"FMN_dh"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00503","properties":[{"key":"EntryName","value":"G-alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00363","properties":[{"key":"EntryName","value":"CYTOCHROMEB5"}]},{"database":"PRINTS","id":"PR00318","properties":[{"key":"EntryName","value":"GPROTEINA"}]},{"database":"PRINTS","id":"PR01241","properties":[{"key":"EntryName","value":"GPROTEINAFNG"}]},{"database":"SMART","id":"SM01117","properties":[{"key":"EntryName","value":"Cyt-b5"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00275","properties":[{"key":"EntryName","value":"G_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55856","properties":[{"key":"EntryName","value":"Cytochrome b5-like heme/steroid binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51395","properties":[{"key":"EntryName","value":"FMN-linked oxidoreductases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47895","properties":[{"key":"EntryName","value":"Transducin (alpha subunit), insertion domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00191","properties":[{"key":"EntryName","value":"CYTOCHROME_B5_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50255","properties":[{"key":"EntryName","value":"CYTOCHROME_B5_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00557","properties":[{"key":"EntryName","value":"FMN_HYDROXY_ACID_DH_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51349","properties":[{"key":"EntryName","value":"FMN_HYDROXY_ACID_DH_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51882","properties":[{"key":"EntryName","value":"G_ALPHA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MWGLNYIMPLIRFEEVAKHTSPDDCWIIIGNKVYNMTSFLPDHPGGPQIIIKNAGTDATRLFESTHPAGTIEKHLPKECYQGDLDLQSVPQAVKAAQEQAEEEEKARRANVPPLAQCLNLNDFEAAGRQAMSPEAWAYYSSAADDEHTLRENRDIFERIWFRPRILRNVQEVDCSTQLLGYPSSMPVYITATALGRLGHPDGELNLTRGAARTGVIQMVPTLSSCSFDEIVQERKDGLPLQFFQLYVNSDRKVVLDMLRRAEEADIKAIFVTVDAPQLGRREKDMRMQFAGEGSNVQGGTVEKRDEGAARAISTFIDPSFDWDDLLFITRNTKLPVLLKGVQAWEDVVLACEMGLAGVVLSNHGGRQLNFAPSSIEVLEESVRELKKRHLFPNKNFQLFVDGGFRRGTDVLKAIALGATAVGLGRPLLYAYSAYGSDGVVRALQLLRDELEMDMRLLGARTLKEVVPEMLDLRALHARGGVSHFAKAHEDVVSRKANSGKPQQRQSKDELKVLLLGSGESGKSTIVKQMKIIHQNGYSEQELYMFRINILKNLLDSIKALALAMRRFNMEPQQLENREAADLLITYELPADADATLPPQVAQAITGLWSDPIMASLLERRARIAQPDYVPTQEDVLHSRSKTTGIVETNFQMGDMRINLVDLGGQRSERSKWIHSFESVTSIIFCVALSEYDQMLLEDPSQNRMAESLVLFESVVNSRTYMALTLGWFLRTSVILFLNKIDIFTKKLPLRPLADYFPDYKGGNDVNKAAKYILWRFTSLNRAKLQIYPHVTQATDTTNIRLVFAAVKEYV","length":810,"molWeight":91042,"crc64":"C0BEE65A43E0198D","md5":"1AC013435BE6D5840E90EB228B49BF99"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":4,"CAUTION":1},"countByFeatureType":{"Domain":2,"Region":5,"Active site":1,"Binding site":18},"uniParcId":"UPI0027989DF2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EG63","uniProtkbId":"A0AAF0EG63_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":10,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21767.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363051"}],"value":"Peroxidase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363051"}],"value":"1.11.1.-"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21767.1"}],"value":"CCP1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21767.1"}],"value":"MEQU1_000423"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00003917"}],"value":"Destroys radicals which are normally produced within the cells and which are toxic to biological systems"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:16581"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16240"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"1.11.1.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049265"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"NADH + O2 + H(+) = H2O2 + NAD(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11264"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16240"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57945"}],"ecNumber":"1.6.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10012"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"NADPH + O2 + H(+) = H2O2 + NADP(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11260"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16240"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.6.3.1","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10012"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004569"}],"value":"Mitochondrion intermembrane space","id":"SL-0169"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004305"}],"value":"Mitochondrion matrix","id":"SL-0170"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005997"}],"value":"Belongs to the peroxidase family. Cytochrome c peroxidase subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00297"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Plant heme peroxidase family profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50873"}]},{"type":"Region","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10012"}]},{"type":"Binding site","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00297"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Site","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00297"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00297"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00297"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00297"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363051"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022559"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU363051"}],"id":"KW-0575","category":"Molecular function","name":"Peroxidase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21767.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21767.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD21767.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0EG63","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005758","properties":[{"key":"GoTerm","value":"C:mitochondrial intermembrane space"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004130","properties":[{"key":"GoTerm","value":"F:cytochrome-c peroxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005506","properties":[{"key":"GoTerm","value":"F:iron ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016174","properties":[{"key":"GoTerm","value":"F:NAD(P)H oxidase H2O2-forming activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0034599","properties":[{"key":"GoTerm","value":"P:cellular response to oxidative stress"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042744","properties":[{"key":"GoTerm","value":"P:hydrogen peroxide catabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000302","properties":[{"key":"GoTerm","value":"P:response to reactive oxygen species"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00691","properties":[{"key":"EntryName","value":"ascorbate_peroxidase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.420.10:FF:000009","properties":[{"key":"EntryName","value":"Ascorbate peroxidase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.520.10:FF:000005","properties":[{"key":"EntryName","value":"Cytochrome c peroxidase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.520.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.420.10","properties":[{"key":"EntryName","value":"Peroxidase, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR044831","properties":[{"key":"EntryName","value":"Ccp1-like"}]},{"database":"InterPro","id":"IPR002016","properties":[{"key":"EntryName","value":"Haem_peroxidase"}]},{"database":"InterPro","id":"IPR010255","properties":[{"key":"EntryName","value":"Haem_peroxidase_sf"}]},{"database":"InterPro","id":"IPR002207","properties":[{"key":"EntryName","value":"Peroxidase_I"}]},{"database":"InterPro","id":"IPR019794","properties":[{"key":"EntryName","value":"Peroxidases_AS"}]},{"database":"InterPro","id":"IPR019793","properties":[{"key":"EntryName","value":"Peroxidases_heam-ligand_BS"}]},{"database":"PANTHER","id":"PTHR31356:SF58","properties":[{"key":"EntryName","value":"CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31356","properties":[{"key":"EntryName","value":"THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00141","properties":[{"key":"EntryName","value":"peroxidase"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00459","properties":[{"key":"EntryName","value":"ASPEROXIDASE"}]},{"database":"PRINTS","id":"PR00458","properties":[{"key":"EntryName","value":"PEROXIDASE"}]},{"database":"SUPFAM","id":"SSF48113","properties":[{"key":"EntryName","value":"Heme-dependent peroxidases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00435","properties":[{"key":"EntryName","value":"PEROXIDASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00436","properties":[{"key":"EntryName","value":"PEROXIDASE_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50873","properties":[{"key":"EntryName","value":"PEROXIDASE_4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASLRTSVRFARNLRVTAPRAVDSSPLMFSRAYSTPAPEAKQGGGSSMLWAAVLAGAAGAAYYYRDDLKALAGGESSSKIPTKQDYQAVYNEIAKILEKEGYDDGSYAPVLIRLAWHSSGTYDKESNTGGSNGATMRFPPEANHSENPGLHNGRDFLEPIKKKFPWISYSDLWTLAGVAAVQEMGGPKIPWRPGREDKPVETTPPDGRLPHAPLGADHIRDVFYRMGFNDQEAVALIGAHAVGRCHTQYSGFDGPWTHTPTMFTNQFFTLLLDESWVPKKWEGPFQYVDKNSNTLMMLPTDYALVKDSAFKKHVQTYAKDQDKFFKDFAAAFGTLIELGVPSENFKKAAESLGDDQPIVFTPTADQP","length":367,"molWeight":40471,"crc64":"462044E6435F9BA8","md5":"EE191C12DE11DCD125B8EA668757A682"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":3,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Region":1,"Active site":1,"Binding site":1,"Site":1},"uniParcId":"UPI0027A169BD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0EHV5","uniProtkbId":"A0AAF0EHV5_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":10,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22637.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012429"}],"value":"protein kinase C"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012429"}],"value":"2.7.11.13"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22637.1"}],"value":"PKC1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22637.1"}],"value":"MEQU1_001311"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.13","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047470"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.13","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047272"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010014"}],"value":"Belongs to the eukaryotic ribosomal protein eS19 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005490"}],"value":"Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00618"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"REM-1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51860"}]},{"type":"Domain","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"C2","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50004"}]},{"type":"Domain","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"Phorbol-ester/DAG-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50081"}]},{"type":"Domain","location":{"start":{"value":502,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"Phorbol-ester/DAG-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50081"}]},{"type":"Domain","location":{"start":{"value":717,"modifier":"EXACT"},"end":{"value":976,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Domain","location":{"start":{"value":977,"modifier":"EXACT"},"end":{"value":1047,"modifier":"EXACT"}},"description":"AGC-kinase C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51285"}]},{"type":"Zinc finger","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"Phorbol-ester/DAG-type","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00226"}]},{"type":"Zinc finger","location":{"start":{"value":502,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"Phorbol-ester/DAG-type","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00226"}]},{"type":"Region","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":707,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1116,"modifier":"EXACT"},"end":{"value":1136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1176,"modifier":"EXACT"},"end":{"value":1206,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":615,"modifier":"EXACT"},"end":{"value":628,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1116,"modifier":"EXACT"},"end":{"value":1129,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1181,"modifier":"EXACT"},"end":{"value":1206,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":842,"modifier":"EXACT"},"end":{"value":842,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":746,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Modified residue","location":{"start":{"value":1018,"modifier":"EXACT"},"end":{"value":1018,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00618"}]},{"type":"Modified residue","location":{"start":{"value":1036,"modifier":"EXACT"},"end":{"value":1036,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00618"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01207"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00226"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00618"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023274"}],"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022980"}],"id":"KW-0689","category":"Molecular function","name":"Ribosomal protein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00226"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00226"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22637.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22637.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119901","properties":[{"key":"ProteinId","value":"WFD22637.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0EHV5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"GO","id":"GO:0005840","properties":[{"key":"GoTerm","value":"C:ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019992","properties":[{"key":"GoTerm","value":"F:diacylglycerol binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004697","properties":[{"key":"GoTerm","value":"F:diacylglycerol-dependent serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0003735","properties":[{"key":"GoTerm","value":"F:structural constituent of ribosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0009272","properties":[{"key":"GoTerm","value":"P:fungal-type cell wall biogenesis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006412","properties":[{"key":"GoTerm","value":"P:translation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd20822","properties":[{"key":"EntryName","value":"C1_ScPKC1-like_rpt1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd20823","properties":[{"key":"EntryName","value":"C1_ScPKC1-like_rpt2"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd11620","properties":[{"key":"EntryName","value":"HR1_PKC-like_2_fungi"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05570","properties":[{"key":"EntryName","value":"STKc_PKC"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.10:FF:000118","properties":[{"key":"EntryName","value":"40S ribosomal protein S19"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000101","properties":[{"key":"EntryName","value":"Protein kinase C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.60.20:FF:000064","properties":[{"key":"EntryName","value":"Protein kinase C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.200.20:FF:000474","properties":[{"key":"EntryName","value":"Serine/threonine-protein kinase N2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.60.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000961","properties":[{"key":"EntryName","value":"AGC-kinase_C"}]},{"database":"InterPro","id":"IPR046349","properties":[{"key":"EntryName","value":"C1-like_sf"}]},{"database":"InterPro","id":"IPR000008","properties":[{"key":"EntryName","value":"C2_dom"}]},{"database":"InterPro","id":"IPR035892","properties":[{"key":"EntryName","value":"C2_domain_sf"}]},{"database":"InterPro","id":"IPR011072","properties":[{"key":"EntryName","value":"HR1_rho-bd"}]},{"database":"InterPro","id":"IPR036274","properties":[{"key":"EntryName","value":"HR1_rpt_sf"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR037312","properties":[{"key":"EntryName","value":"PKC-like_HR1"}]},{"database":"InterPro","id":"IPR002219","properties":[{"key":"EntryName","value":"PKC_DAG/PE"}]},{"database":"InterPro","id":"IPR017892","properties":[{"key":"EntryName","value":"Pkinase_C"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR001266","properties":[{"key":"EntryName","value":"Ribosomal_eS19"}]},{"database":"InterPro","id":"IPR018277","properties":[{"key":"EntryName","value":"Ribosomal_eS19_CS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"PANTHER","id":"PTHR24351","properties":[{"key":"EntryName","value":"RIBOSOMAL PROTEIN S6 KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00130","properties":[{"key":"EntryName","value":"C1_1"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF02185","properties":[{"key":"EntryName","value":"HR1"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00433","properties":[{"key":"EntryName","value":"Pkinase_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01090","properties":[{"key":"EntryName","value":"Ribosomal_S19e"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00109","properties":[{"key":"EntryName","value":"C1"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00742","properties":[{"key":"EntryName","value":"Hr1"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM01413","properties":[{"key":"EntryName","value":"Ribosomal_S19e"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00133","properties":[{"key":"EntryName","value":"S_TK_X"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49562","properties":[{"key":"EntryName","value":"C2 domain (Calcium/lipid-binding domain, CaLB)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57889","properties":[{"key":"EntryName","value":"Cysteine-rich domain"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF46585","properties":[{"key":"EntryName","value":"HR1 repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51285","properties":[{"key":"EntryName","value":"AGC_KINASE_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50004","properties":[{"key":"EntryName","value":"C2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51860","properties":[{"key":"EntryName","value":"REM_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00628","properties":[{"key":"EntryName","value":"RIBOSOMAL_S19E"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00479","properties":[{"key":"EntryName","value":"ZF_DAG_PE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50081","properties":[{"key":"EntryName","value":"ZF_DAG_PE_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGKIADLESRISKQRRIIEGFQSLCHATPNQDVIRQAESNIRSAQRTISFLEESLAQLQRRDVSHMAAATGRPGDAPAAMASRQTAGSIPEVSPASLPSSPMRPMDAGMPPAASFPIDSSAAYRAQVPGGAPDAGRRAYTALDLLRYDTPLTSAKVQRKLDQLQYKLQLERQYKLGYDKIAQLYQAEGDRRSQDDAKSQRMETASKMVLIQQALSRYQHMHIQDGPEIENPYANRRPRKPQPGTLRIAIEAARDVDHAPMPSGLRLSRESFVAVKIEELDRVHTHASRNDTWGECFELPMEDTSEVELILFDRVGTTAPVPVGLLWLRVSDIVEHLRKIKFGQVGADGTATPSPASEIPVAPWAPGTVPDAATTASSAVTDQGVEGWFTVEPTGALYLRLSYVKQHGPKRPVEQGLGRQGAVRMRPKEVSEVNGHRFVSRQFYQMIRCAFCGELLLNASGAQCEDCQYTCHRKCAQKVVIRCVRRSGTGPDNDDVNVKHRIPHRFEPFSNLGANWCCHCGSMLSLGRRSNRKCSECDITCHADCAHLVPDFCGMSMDMANQMMSNIATIKKNRLSIKSPLPQLATPRTPAVDARRTSADSLSSSMQGLQVSPRPGWASSGLSPAGSGATTPTAPKHMQLPPSTSMPYTAPPMPTTPVTRRPVADGAAMSPASGALKPSPGPGPTLATSAATSPQKRRSATAMEFPPSSDRKVALEDFNFLAVLGKGNFGKVMLAEEKQTGQLFAIKVLKKEFIIENDEIDSTRSEKRVFLTAAREQHPFLLSLHSCFQTETRVYFVMEYVSGGDLMLHIQREQFNLHRAKFYAAEVLLALEYFHKHGIIYRDLKLDNIMLTLDGHIKIADYGLCKEGMWYGNTTSTFCGTPEFMAPEILLEQRYGRAVDWWAFGILLYEMLLGQAPFRGDDEDEIFDAILEDEPLYPIQMPRDSVSLLQRLLTRDPARRLGAGPNDAEEVKAHPFFRDVNWDDLLHKRVTPPFLPTLKNASDTTWFDTEFTSEKPTLTPVHSIFSPQDQAEFRDFSWTNPHIIVRDVDAAQFINAYAQHLKRSGKLEMPTWVDIVKTGAYKEQAPYDPDWYYVRAAALARHIYLRKSVGVGKLRKLHGGPKNRGFRPSHHSPASGAVQRKVLQSLEQIGVLEISEKGGRSITQDGMRDLDRIAVAVLEAQREDEDDEDEDEDDEDEDEDDEDEDDE","length":1206,"molWeight":134262,"crc64":"A2ECD583B471E633","md5":"FA67D5129A439B1B3ED2B866DD7A9820"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":4,"SIMILARITY":3,"CAUTION":1},"countByFeatureType":{"Domain":6,"Zinc finger":2,"Region":4,"Coiled coil":1,"Compositional bias":4,"Active site":1,"Binding site":1,"Modified residue":2},"uniParcId":"UPI00279887DC"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0IXW8","uniProtkbId":"A0AAF0IXW8_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":12,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22251.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013184"}],"value":"histone acetyltransferase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013184"}],"value":"2.3.1.48"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22251.1"}],"value":"ESA1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22251.1"}],"value":"MEQU1_000917"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045805"}],"value":"Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:53908"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:13707"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57332"},{"database":"ChEBI","id":"CHEBI:137954"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047752"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:53909"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047752"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:24180"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:15921"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:131780"},{"database":"ChEBI","id":"CHEBI:144968"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047557"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:24181"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047557"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21992"},{"database":"Rhea","id":"RHEA-COMP:9845"},{"database":"Rhea","id":"RHEA-COMP:11338"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"ecNumber":"2.3.1.48","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048940"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:21993"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048940"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45948"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:10731"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"ecNumber":"2.3.1.48","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:45948"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:10731"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:61930"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047787"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:45949"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047787"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011353"}],"value":"Component of the NuA4 histone acetyltransferase complex"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004286"}],"value":"Chromosome","id":"SL-0468"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010107"}],"value":"Belongs to the MYST (SAS/MOZ) family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"MYST-type HAT","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51726"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR602717-51"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}]},{"type":"Binding site","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57288"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}],"ligand":{"name":"acetyl-CoA","id":"ChEBI:CHEBI:57288"}},{"type":"Binding site","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57288"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}],"ligand":{"name":"acetyl-CoA","id":"ChEBI:CHEBI:57288"}},{"type":"Modified residue","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"N6-acetyllysine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023159"}],"id":"KW-0010","category":"Molecular function","name":"Activator"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22251.1"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022454"}],"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022763"}],"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023204"}],"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01063"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22251.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22251.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119901","properties":[{"key":"ProteinId","value":"WFD22251.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0IXW8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004402","properties":[{"key":"GoTerm","value":"F:histone acetyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003712","properties":[{"key":"GoTerm","value":"F:transcription coregulator activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"1.10.10.10:FF:000022","properties":[{"key":"EntryName","value":"Histone acetyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.60.60:FF:000001","properties":[{"key":"EntryName","value":"Histone acetyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.630.30:FF:000002","properties":[{"key":"EntryName","value":"Histone acetyltransferase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.30.140","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.630.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.60.60","properties":[{"key":"EntryName","value":"N-acetyl transferase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.10","properties":[{"key":"EntryName","value":"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016181","properties":[{"key":"EntryName","value":"Acyl_CoA_acyltransferase"}]},{"database":"InterPro","id":"IPR016197","properties":[{"key":"EntryName","value":"Chromo-like_dom_sf"}]},{"database":"InterPro","id":"IPR002717","properties":[{"key":"EntryName","value":"HAT_MYST-type"}]},{"database":"InterPro","id":"IPR050603","properties":[{"key":"EntryName","value":"MYST_HAT"}]},{"database":"InterPro","id":"IPR025995","properties":[{"key":"EntryName","value":"Tudor-knot"}]},{"database":"InterPro","id":"IPR036388","properties":[{"key":"EntryName","value":"WH-like_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR040706","properties":[{"key":"EntryName","value":"Zf-MYST"}]},{"database":"PANTHER","id":"PTHR10615","properties":[{"key":"EntryName","value":"HISTONE ACETYLTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10615:SF218","properties":[{"key":"EntryName","value":"HISTONE ACETYLTRANSFERASE ESA1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01853","properties":[{"key":"EntryName","value":"MOZ_SAS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11717","properties":[{"key":"EntryName","value":"Tudor-knot"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17772","properties":[{"key":"EntryName","value":"zf-MYST"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55729","properties":[{"key":"EntryName","value":"Acyl-CoA N-acyltransferases (Nat)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54160","properties":[{"key":"EntryName","value":"Chromo domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51726","properties":[{"key":"EntryName","value":"MYST_HAT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPRANAADKQGSEPARKSAGGEYTLKDIQVGAKLFVEKTNPDNGEVEQRLAEVLSTRERRQNRLHMLQAMHERGDDKIDEKEPELDFYVHYCDFNKRLDEWVPSARLILTREMEWPKPPDPATNKHTKRKVVQGVRAVQTPTPTPGTPTPGTSPSASLEDLKEEETFSKEKEVEKLRTSGSMTQCASEVSRVKNLNMLQMGKHQIEAWYFSPYPMEYAYIDCLYVCEMCLSYYPSDFMLKRHRHKCKMLHPPGNEIYRCDDISFFEIDGRRQKTWCRNLCLLSKCFLDHKTLYYDVDPFLYYVMCQRDNTGCHLIGYFSKEKESAEGYNVACILTLPQHQRSGFGRLLIEFSYELSKRENKLGSPEKPLSDLGLLGYRAYWSETIVELLLKTDEDISIDEIATKTSILHADVLQTCQALNMLKQYQGKHYLVLSDAIIEKHERQMKKKRRRIHPEHLHWKPPVFTRDQLRFGW","length":474,"molWeight":55246,"crc64":"01943F17CA58492C","md5":"9BF31EB6F4D0413FD1F5909AC9887CE9"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":5,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Region":2,"Active site":1,"Binding site":2,"Modified residue":1},"uniParcId":"UPI00279D2FDD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0IYY6","uniProtkbId":"A0AAF0IYY6_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":11,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23439.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021157"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU367134"}],"value":"Aurora kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU367134"}],"value":"2.7.11.1"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23439.1"}],"value":"IPL1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23439.1"}],"value":"MEQU1_002129"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU367134"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047899"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU367134"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004186"}],"value":"Cytoplasm, cytoskeleton, spindle","id":"SL-0251"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU367134"}],"value":"Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR630616-1"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10027"}]},{"type":"Binding site","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR630616-2"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR630616-2"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10141"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR630616-2"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR630616-2"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR630616-2"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Cross-link","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR630616-3"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR630616-2"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR630616-2"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23439.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23439.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119903","properties":[{"key":"ProteinId","value":"WFD23439.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0IYY6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"GO","id":"GO:0032133","properties":[{"key":"GoTerm","value":"C:chromosome passenger complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000776","properties":[{"key":"GoTerm","value":"C:kinetochore"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0051233","properties":[{"key":"GoTerm","value":"C:spindle midzone"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008608","properties":[{"key":"GoTerm","value":"P:attachment of spindle microtubules to kinetochore"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0045143","properties":[{"key":"GoTerm","value":"P:homologous chromosome segregation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0044779","properties":[{"key":"GoTerm","value":"P:meiotic spindle checkpoint signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0032465","properties":[{"key":"GoTerm","value":"P:regulation of cytokinesis"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0090266","properties":[{"key":"GoTerm","value":"P:regulation of mitotic cell cycle spindle assembly checkpoint"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:1902115","properties":[{"key":"GoTerm","value":"P:regulation of organelle assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0072479","properties":[{"key":"GoTerm","value":"P:response to mitotic cell cycle spindle assembly checkpoint signaling"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0000819","properties":[{"key":"GoTerm","value":"P:sister chromatid segregation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd14007","properties":[{"key":"EntryName","value":"STKc_Aurora"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.510.10:FF:000235","properties":[{"key":"EntryName","value":"Serine/threonine-protein kinase ark1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR030616","properties":[{"key":"EntryName","value":"Aur-like"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR017441","properties":[{"key":"EntryName","value":"Protein_kinase_ATP_BS"}]},{"database":"InterPro","id":"IPR008271","properties":[{"key":"EntryName","value":"Ser/Thr_kinase_AS"}]},{"database":"PANTHER","id":"PTHR24350","properties":[{"key":"EntryName","value":"SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00220","properties":[{"key":"EntryName","value":"S_TKc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00107","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ATP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00108","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_ST"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGEGESAGLEARMTSMSLGPHESKTQSRSHGATALMNTTWLASQQRKVAPPPFQPRPLKTATKVESSAAAQPRAPLVSKHGVSNLSAHPPASSRGSVAQAQARPAGLSSTASQNSRAAPSEVKLDLGHYDGGLERDERKGRREASQSDEADTLAMDSSMDGLQHQPTRPWGLSQFEIGRPLGKGKFGRVYLARTKASPSSYPGHQGYVVALKCVYKKELVENKVDLQLRREIEIQMNLRHPNVLRMFGYFHDPGRIFMMLEFAGRGELFKILSKLPERRFDEATAAKYIAQIADALQYLHSKHIIHRDIKPENLLVGIRGEVKIADFGWSVHAPGNRRATLCGTLDYLPPEMVEGKSHGGAVDLWAMGVLTYEFLEGVPPFEELSGASMTYKRIASVDLHIPTHFSEEAKDLVRSLLRYHPTDRLPLSKVLRHPWIMRYDPQAFVRASRYVRADSA","length":456,"molWeight":50590,"crc64":"B44E546C70D2FE7B","md5":"8C1A4BB53074AB46C077CFD08AF24091"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":1,"Compositional bias":3,"Active site":1,"Binding site":5,"Cross-link":1},"uniParcId":"UPI0027A6B351"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0IYZ8","uniProtkbId":"A0AAF0IYZ8_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-05-29","entryVersion":8,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23406.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"value":"Lon protease homolog, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"value":"3.4.21.53"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23406.1"}],"value":"PIM1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23406.1"}],"value":"MEQU1_002095"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"value":"ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Hydrolysis of proteins in presence of ATP.","ecNumber":"3.4.21.53","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"value":"Homohexamer or homoheptamer. Organized in a ring with a central cavity"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004305"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"value":"Mitochondrion matrix","id":"SL-0170"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR001174"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01122"}],"value":"Belongs to the peptidase S16 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"Lon N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51787"}]},{"type":"Domain","location":{"start":{"value":724,"modifier":"EXACT"},"end":{"value":911,"modifier":"EXACT"}},"description":"Lon proteolytic","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51786"}]},{"type":"Region","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":667,"modifier":"EXACT"},"end":{"value":688,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":667,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":677,"modifier":"EXACT"},"end":{"value":688,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":816,"modifier":"EXACT"},"end":{"value":816,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001174-1"}]},{"type":"Active site","location":{"start":{"value":859,"modifier":"EXACT"},"end":{"value":859,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001174-1"}]},{"type":"Binding site","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001174-2"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022825"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03120"}],"id":"KW-0720","category":"Molecular function","name":"Serine protease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23406.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23406.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119903","properties":[{"key":"ProteinId","value":"WFD23406.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0IYZ8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016887","properties":[{"key":"GoTerm","value":"F:ATP hydrolysis activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004176","properties":[{"key":"GoTerm","value":"F:ATP-dependent peptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0004252","properties":[{"key":"GoTerm","value":"F:serine-type endopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003697","properties":[{"key":"GoTerm","value":"F:single-stranded DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0034599","properties":[{"key":"GoTerm","value":"P:cellular response to oxidative stress"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0051131","properties":[{"key":"GoTerm","value":"P:chaperone-mediated protein complex assembly"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007005","properties":[{"key":"GoTerm","value":"P:mitochondrion organization"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0070407","properties":[{"key":"GoTerm","value":"P:oxidation-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006515","properties":[{"key":"GoTerm","value":"P:protein quality control for misfolded or incompletely synthesized proteins"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd19500","properties":[{"key":"EntryName","value":"RecA-like_Lon"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000021","properties":[{"key":"EntryName","value":"Lon protease homolog"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.8.60:FF:000184","properties":[{"key":"EntryName","value":"Lon protease homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.5270:FF:000001","properties":[{"key":"EntryName","value":"Lon protease homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.58.1480:FF:000003","properties":[{"key":"EntryName","value":"Lon protease homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.130.40:FF:000010","properties":[{"key":"EntryName","value":"Lon protease homolog, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.8.60","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.5270","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.58.1480","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.230.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.130.40","properties":[{"key":"EntryName","value":"LON domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03120","properties":[{"key":"EntryName","value":"lonm_euk"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR003959","properties":[{"key":"EntryName","value":"ATPase_AAA_core"}]},{"database":"InterPro","id":"IPR004815","properties":[{"key":"EntryName","value":"Lon_bac/euk-typ"}]},{"database":"InterPro","id":"IPR054594","properties":[{"key":"EntryName","value":"Lon_lid"}]},{"database":"InterPro","id":"IPR008269","properties":[{"key":"EntryName","value":"Lon_proteolytic"}]},{"database":"InterPro","id":"IPR027065","properties":[{"key":"EntryName","value":"Lon_Prtase"}]},{"database":"InterPro","id":"IPR003111","properties":[{"key":"EntryName","value":"Lon_prtase_N"}]},{"database":"InterPro","id":"IPR046336","properties":[{"key":"EntryName","value":"Lon_prtase_N_sf"}]},{"database":"InterPro","id":"IPR027503","properties":[{"key":"EntryName","value":"Lonm_euk"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR015947","properties":[{"key":"EntryName","value":"PUA-like_sf"}]},{"database":"InterPro","id":"IPR020568","properties":[{"key":"EntryName","value":"Ribosomal_Su5_D2-typ_SF"}]},{"database":"InterPro","id":"IPR014721","properties":[{"key":"EntryName","value":"Ribsml_uS5_D2-typ_fold_subgr"}]},{"database":"NCBIfam","id":"TIGR00763","properties":[{"key":"EntryName","value":"lon"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43718","properties":[{"key":"EntryName","value":"LON PROTEASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43718:SF2","properties":[{"key":"EntryName","value":"LON PROTEASE HOMOLOG, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00004","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05362","properties":[{"key":"EntryName","value":"Lon_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22667","properties":[{"key":"EntryName","value":"Lon_lid"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02190","properties":[{"key":"EntryName","value":"LON_substr_bdg"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001174","properties":[{"key":"EntryName","value":"Lon_proteas"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00830","properties":[{"key":"EntryName","value":"ENDOLAPTASE"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00464","properties":[{"key":"EntryName","value":"LON"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF88697","properties":[{"key":"EntryName","value":"PUA domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54211","properties":[{"key":"EntryName","value":"Ribosomal protein S5 domain 2-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51787","properties":[{"key":"EntryName","value":"LON_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51786","properties":[{"key":"EntryName","value":"LON_PROTEOLYTIC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVSRNTVPTVYPQVLALPISRRPLFPGFYKAVVIKDPHVCAAIKEATERGQPYVGAFLLKDEEEDSDIIVNLDRVHRVGVFAQITSIFPTNTSGKADASEDGITAVLYPHRRIVIDELITPVRKEDVGTSVQESSSEENAEPSGEQQSILEGDSTTQSESKLDIQETKDMPENVEPSEELPSHTPPFQTAFLHQYEVSLVNVTNLEMEPYDKKPNQYIRAVMSELISVFKDIANLNPLFRDQIANFSISQGAGNVFEEPEKLADFAAAVSSSEVDELQGVLESMNVEERLQKALLVLKKELVNAQLQSKISKDVENKIQKRQREYYLMEQLKGIKRELGIESDGKDKLIEKYKEKAAKLNMPEAVHKVFDEELAKLQSLEQAASEFNVTRGYLEWITSIPWGVHSRDNYAIKRAAEVLDQDHFGLKDVKNRILEFLAVGKLRGTVEGKIICLVGPPGVGKTSIGKSISKALGREFYRFSVGGLSDVAEIKGHRRTYVGAMPGKAIQALKKVGTENPLILIDEVDKLARGYNGDPSSALLEMLDPEQNASFMDHYLDVPVDLSRVLFVCTANTLSTIPQPLLDRMEVIEVSSYTAEEKRHIARDYLAPQAMEASGLKDAQVTLPDESIDFLIKRYARESGVRSLRKLLEKVYRKVAYDIVKEHGEEVFPEPELSEQADTDKEKVTTEPREPMKIPSTVSLVITEDKLREYLGPPLYHKDRLYTQTMPAGVALGLGYLGNGSGSLMPIETTLMPGKGHLQLTGKLGDVIKESATIALSWAKTHAFELGMTKEQDTSLLNSRDVHLHMPEGAIGKDGPSAGVAFAVSLISLLLNRPLPTTLAMTGEVSLRGMVLPVGGLKEKLLAAHRAGVTTLILPAQNRPSVEADVPKMVLDDLDVHYVTNVWAALEIAFGPGPWSEQARVWNANESPEAASQ","length":932,"molWeight":103035,"crc64":"0FFF2F98572A85A7","md5":"2969C726B31466CDF15AA32F59574B99"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Region":2,"Compositional bias":4,"Active site":2,"Binding site":1},"uniParcId":"UPI0027A16200"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0IZ35","uniProtkbId":"A0AAF0IZ35_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2024-05-29","entryVersion":7,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23032.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Phosphatidylserine decarboxylase proenzyme 1, mitochondrial"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"4.1.1.65"}]},"contains":[{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Phosphatidylserine decarboxylase 1 beta chain"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Phosphatidylserine decarboxylase 1 alpha chain"}}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23032.1"}],"value":"PSD1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23032.1"}],"value":"MEQU1_001716"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:20828"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:57262"},{"database":"ChEBI","id":"CHEBI:64612"}],"ecNumber":"4.1.1.65","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"pyruvate","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:15361"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Binds 1 pyruvoyl group covalently per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00005189"}],"value":"Lipid metabolism"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","molecule":"Phosphatidylserine decarboxylase 1 alpha chain","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Intermembrane side","id":"SL-9912"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Phosphatidylserine decarboxylase 1 beta chain","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Single-pass membrane protein","id":"SL-9904"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Intermembrane side","id":"SL-9912"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"value":"Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":507,"modifier":"EXACT"}},"description":"Phosphatidylserine decarboxylase 1 beta chain","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"featureId":"PRO_5041755969"},{"type":"Chain","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"Phosphatidylserine decarboxylase 1 alpha chain","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"featureId":"PRO_5041755968"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}]},{"type":"Topological domain","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"Mitochondrial intermembrane","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}]},{"type":"Region","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Charge relay system; for autoendoproteolytic cleavage activity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}]},{"type":"Active site","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"Charge relay system; for autoendoproteolytic cleavage activity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}]},{"type":"Active site","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"Charge relay system; for autoendoproteolytic cleavage activity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}]},{"type":"Active site","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}]},{"type":"Site","location":{"start":{"value":507,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"Cleavage (non-hydrolytic); by autocatalysis","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}]},{"type":"Modified residue","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"Pyruvic acid (Ser); by autocatalysis","evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022793"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0210","category":"Molecular function","name":"Decarboxylase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022516"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0444","category":"Biological process","name":"Lipid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023098"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023209"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0594","category":"Biological process","name":"Phospholipid biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023264"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-1208","category":"Biological process","name":"Phospholipid metabolism"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023317"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0670","category":"Ligand","name":"Pyruvate"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03208"}],"id":"KW-0865","category":"PTM","name":"Zymogen"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23032.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD23032.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119902","properties":[{"key":"ProteinId","value":"WFD23032.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0IZ35","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004609","properties":[{"key":"GoTerm","value":"F:phosphatidylserine decarboxylase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006646","properties":[{"key":"GoTerm","value":"P:phosphatidylethanolamine biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0016540","properties":[{"key":"GoTerm","value":"P:protein autoprocessing"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"HAMAP","id":"MF_03208","properties":[{"key":"EntryName","value":"PS_decarb_PSD_B_type1_euk"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003817","properties":[{"key":"EntryName","value":"PS_Dcarbxylase"}]},{"database":"InterPro","id":"IPR033177","properties":[{"key":"EntryName","value":"PSD-B"}]},{"database":"InterPro","id":"IPR033661","properties":[{"key":"EntryName","value":"PSD_type1_euk"}]},{"database":"NCBIfam","id":"TIGR00163","properties":[{"key":"EntryName","value":"PS_decarb"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10067","properties":[{"key":"EntryName","value":"PHOSPHATIDYLSERINE DECARBOXYLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10067:SF6","properties":[{"key":"EntryName","value":"PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02666","properties":[{"key":"EntryName","value":"PS_Dcarbxylase"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MWGRARPRVPPLGRGPGVVSRAYARDPNEAVHAATTVRGHRAERARLQSLHQAPRRASIWTRAWRTWRETPLKWSPIPIFLGGAVLVAVQARREHQQRREAPVVDEHGQPVRRMGPWTMYILGVIPFNAISRTWGWFNDLTLPVWFRPYGFQLYARLFGCHLDEMKEKDLRQYANLADFFVRELEPGARPISPSLLVSPADGKVLHLGVVEGDRVEQVKGLTYSLGSLLGYHTPAHAHDDALLDDARTWDVADERHFAQVNGIDYTLEELLGDKRRPFRLHAYLQGWAKGAWRWMSLTLRGKRSAYQHVPTHEVQPTELAREQANKEDAELSEQGDAGIPTADSAETLSHYAQVAMDMGSASLPGWNTPGPRTPGHRLYFCVIYLSPGDYHRFHSPAPWVVELRRHFRGELYSVAPSIAASLPNLFVVNERVALLGRWRHGFFSMTPIGATNVGSIQIHFDRNLRTNQHTERQLAGSFTEATYHAASRLLGGQPLAPGDEMGCFRLGSTVVLVFEAPESFRFHCRAGDRVQVGEALGDVA","length":540,"molWeight":60787,"crc64":"9D0CE10D114745D6","md5":"D4585EE8A66676FD3083D4839C1D86C9"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":2,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":2,"Topological domain":2,"Region":1,"Compositional bias":1,"Active site":4,"Site":1,"Modified residue":1},"uniParcId":"UPI0027A2C44C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E7S7","uniProtkbId":"A0AAF0E7S7_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":9,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21372.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00020771"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000515"}],"value":"Delta-aminolevulinic acid dehydratase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012053"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000515"}],"value":"4.2.1.24"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21372.1"}],"value":"HEM2"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21372.1"}],"value":"MEQU1_000020"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025628"}],"value":"Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:24064"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58126"},{"database":"ChEBI","id":"CHEBI:356416"}],"ecNumber":"4.2.1.24","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047651"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000515"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001947"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004694"}],"value":"Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000515"}],"value":"Homooctamer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008055"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004161"}],"value":"Belongs to the ALAD family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Active site","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Schiff-base intermediate with substrate","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-1"}]},{"type":"Active site","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"Schiff-base intermediate with substrate","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-1"}]},{"type":"Binding site","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-3"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-3"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-3"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:356416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-2"}],"ligand":{"name":"5-aminolevulinate","id":"ChEBI:CHEBI:356416","label":"1"}},{"type":"Binding site","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:356416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-2"}],"ligand":{"name":"5-aminolevulinate","id":"ChEBI:CHEBI:356416","label":"1"}},{"type":"Binding site","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:356416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-2"}],"ligand":{"name":"5-aminolevulinate","id":"ChEBI:CHEBI:356416","label":"2"}},{"type":"Binding site","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:356416"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-2"}],"ligand":{"name":"5-aminolevulinate","id":"ChEBI:CHEBI:356416","label":"2"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023133"}],"id":"KW-0350","category":"Biological process","name":"Heme biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023239"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000515"}],"id":"KW-0456","category":"Molecular function","name":"Lyase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-3"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023244"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000515"}],"id":"KW-0627","category":"Biological process","name":"Porphyrin biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR001415-3"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21372.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21372.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD21372.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0E7S7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004655","properties":[{"key":"GoTerm","value":"F:porphobilinogen synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006783","properties":[{"key":"GoTerm","value":"P:heme biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"3.20.20.70:FF:000048","properties":[{"key":"EntryName","value":"Delta-aminolevulinic acid dehydratase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.20.20.70","properties":[{"key":"EntryName","value":"Aldolase class I"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001731","properties":[{"key":"EntryName","value":"ALAD"}]},{"database":"InterPro","id":"IPR030656","properties":[{"key":"EntryName","value":"ALAD_AS"}]},{"database":"InterPro","id":"IPR013785","properties":[{"key":"EntryName","value":"Aldolase_TIM"}]},{"database":"NCBIfam","id":"NF006762","properties":[{"key":"EntryName","value":"hemB"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11458","properties":[{"key":"EntryName","value":"DELTA-AMINOLEVULINIC ACID DEHYDRATASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11458:SF0","properties":[{"key":"EntryName","value":"DELTA-AMINOLEVULINIC ACID DEHYDRATASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00490","properties":[{"key":"EntryName","value":"ALAD"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF001415","properties":[{"key":"EntryName","value":"Porphbilin_synth"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00144","properties":[{"key":"EntryName","value":"DALDHYDRTASE"}]},{"database":"SMART","id":"SM01004","properties":[{"key":"EntryName","value":"ALAD"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51569","properties":[{"key":"EntryName","value":"Aldolase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00169","properties":[{"key":"EntryName","value":"D_ALA_DEHYDRATASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPNQFRWGFNRLEEFLGPLVERGLASVILFGIPVLKEKDECGTLADDVEGPVIQAIQKIRALFPSVYVAADVCLCEYTSHGHCGVLLDDGTIDNPKSIARLADVAVAYAKAGAHCVAPSDMMDGRIASIRQALVDHGLAGSTSLMAYSAKFASSMYGPFREAVASAPSFGDRRCYQLPANGRGIARRAIVRDVQEGADIIMVKPALPYLDILADARELASDYPLACYQVSGEYAMLHATANAGVGDLRRLVEETMVSFLRAGASLILTYFTPELLEWLDSPALA","length":284,"molWeight":30632,"crc64":"DA3A689F6148EDA7","md5":"81F782B811AD06B5817C27A14A7A6CDB"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Active site":2,"Binding site":7},"uniParcId":"UPI00279D564A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E7U7","uniProtkbId":"A0AAF0E7U7_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":10,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21402.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00017363"}],"value":"Transcription initiation factor TFIID subunit 2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00076306"}],"value":"TBP-associated factor 2"}}]},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21402.1"}],"value":"MEQU1_000051"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025346"}],"value":"Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00037565"}],"value":"Is probably involved in a pathway contributing to genomic integrity"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004115"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004115"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00038311"}],"value":"Belongs to the IRC22 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010937"}],"value":"Belongs to the TAF2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":1739,"modifier":"EXACT"},"end":{"value":1757,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1131,"modifier":"EXACT"},"end":{"value":1238,"modifier":"EXACT"}},"description":"Bromo","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50014"}]},{"type":"Domain","location":{"start":{"value":1360,"modifier":"EXACT"},"end":{"value":1466,"modifier":"EXACT"}},"description":"Bromo","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50014"}]},{"type":"Domain","location":{"start":{"value":1470,"modifier":"EXACT"},"end":{"value":1578,"modifier":"EXACT"}},"description":"Bromo","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50014"}]},{"type":"Region","location":{"start":{"value":1098,"modifier":"EXACT"},"end":{"value":1130,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1246,"modifier":"EXACT"},"end":{"value":1367,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1770,"modifier":"EXACT"},"end":{"value":1813,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1277,"modifier":"EXACT"},"end":{"value":1286,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1788,"modifier":"EXACT"},"end":{"value":1799,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1802,"modifier":"EXACT"},"end":{"value":1813,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023117"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00035"}],"id":"KW-0103","category":"Domain","name":"Bromodomain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022824"}],"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023015"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21402.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21402.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD21402.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005669","properties":[{"key":"GoTerm","value":"C:transcription factor TFIID complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016251","properties":[{"key":"GoTerm","value":"F:RNA polymerase II general transcription initiation factor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006325","properties":[{"key":"GoTerm","value":"P:chromatin organization"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0006367","properties":[{"key":"GoTerm","value":"P:transcription initiation at RNA polymerase II promoter"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd04369","properties":[{"key":"EntryName","value":"Bromodomain"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd09839","properties":[{"key":"EntryName","value":"M1_like_TAF2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.390.10:FF:000011","properties":[{"key":"EntryName","value":"Transcription initiation factor TFIID subunit"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.920.10","properties":[{"key":"EntryName","value":"Bromodomain-like"},{"key":"MatchStatus","value":"3"}]},{"database":"Gene3D","id":"1.10.390.10","properties":[{"key":"EntryName","value":"Neutral Protease Domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1730","properties":[{"key":"EntryName","value":"tricorn interacting facor f3 domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR042097","properties":[{"key":"EntryName","value":"Aminopeptidase_N-like_N_sf"}]},{"database":"InterPro","id":"IPR001487","properties":[{"key":"EntryName","value":"Bromodomain"}]},{"database":"InterPro","id":"IPR036427","properties":[{"key":"EntryName","value":"Bromodomain-like_sf"}]},{"database":"InterPro","id":"IPR018359","properties":[{"key":"EntryName","value":"Bromodomain_CS"}]},{"database":"InterPro","id":"IPR057345","properties":[{"key":"EntryName","value":"Ig-like_TAF2"}]},{"database":"InterPro","id":"IPR027268","properties":[{"key":"EntryName","value":"Peptidase_M4/M1_CTD_sf"}]},{"database":"InterPro","id":"IPR037813","properties":[{"key":"EntryName","value":"TAF2"}]},{"database":"InterPro","id":"IPR057991","properties":[{"key":"EntryName","value":"TPR_TAF2_C"}]},{"database":"InterPro","id":"IPR005595","properties":[{"key":"EntryName","value":"TRAP_alpha"}]},{"database":"PANTHER","id":"PTHR15137","properties":[{"key":"EntryName","value":"TRANSCRIPTION INITIATION FACTOR TFIID"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15137:SF9","properties":[{"key":"EntryName","value":"TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00439","properties":[{"key":"EntryName","value":"Bromodomain"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF25316","properties":[{"key":"EntryName","value":"TAF2_3rd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25577","properties":[{"key":"EntryName","value":"TPR_TAF2_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03896","properties":[{"key":"EntryName","value":"TRAP_alpha"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00503","properties":[{"key":"EntryName","value":"BROMODOMAIN"}]},{"database":"SMART","id":"SM00297","properties":[{"key":"EntryName","value":"BROMO"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF47370","properties":[{"key":"EntryName","value":"Bromodomain"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF63737","properties":[{"key":"EntryName","value":"Leukotriene A4 hydrolase N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55486","properties":[{"key":"EntryName","value":"Metalloproteases ('zincins'), catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00633","properties":[{"key":"EntryName","value":"BROMODOMAIN_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50014","properties":[{"key":"EntryName","value":"BROMODOMAIN_2"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MPTDRGFTLSHQKVALELSFRSGLAGYTELAVTPAQADLRHVYLHARCMEIQRVLCNGKEAIYTHSDPRATVLPLSDVHGHAQTKRAWFSASSQAAEGELQITLPEGVRAERVPGSTEGSEDEYAPITVRVDYVLDDVHEAIHVVVPTAEAPYRVPHLYTRPTGPNSARCWVPCVDSLWDRCTWELEFVVPRTLATDAPDDEPEVLVVASGELTEHAVHPHDPAKSIFYYTQPVATSVQHVAFCAGPFVLARLSPAGQEGCEALAFCLPAHEHELRTTAQFTWQAIEFISSEYGSYPFASFKLVFVDDTLVDCHPACTLAVCSSDLLHPPSVIDQAFENRHLLSHAVAFQWVGINIVQKTWADTWLIHGLSQHLASMFLRRLLGNNEYRFRMKKDCDRLCMWDIGMPPLYQVGREEPLDEQLLPFVNLKAPLVLYLLDRRLCKMGASLGLGRVIPKLFLQAITGEMTNNALGTHSFLRTCKKVSGADLRLFVDQWINGSGCPRFVCTATFNRKKLLIEMHVRQESPAALYAQARPEDALLSNPVTLWEGQMTVRIHEADGTPYEHVLDIKNEHQRYDVPFNTKYKRVRRNTKRFQARQAAAAAAAAGDEDAAEAIGMIDLGFGLGMWEDENERERWKVADWTEEDEAIMASAPYEWIRLDADFEWMAQIQFEQPDYMWVSQLQRDRDVVAQLAAVHALSQMPSLITSSMLTRTVLVTKYFYRIRAEAAYGLANCALPHLDLLGLFHLLLLFRTSYCLDVPDGGDATALEAPCIPRPNDFSDMADYYVRRALIHAIARVRDHRGRALPIVQRFLINLLRYNDNSTNRFVDDYYLASIINALATTLIPVDSTGFTTHADEVYTDEELTLRQLATQEVERLQVLDRLVPSFHNVVTLAALDFQLSLVLANLRPLDLPHFVEYTREGNWTAVRVAAFNALLLLRGLQHKVLTRYYFAVLSTDEDPVVRMHLARGLCDALAVAMATGELGVAWQRQETLQEGDPRDNVAEQEALLAQEAAQVEQVVKVLRREIGRSASVRDGFLAAFQASRDHVGTRLALMRLAELLFKGTEDTKVTSDRTAAAANDEHTGAMRIRLLIKNAPQQEKRSSQPLKVVLPKAPKPKKPKAPEPGQALGMSASDLSACRTCIHKLMANKHCEPFTRPVDPVRDEAPDYFDVIKEPMDLSSVSNKLQSGQYKDRFQFKEDVELIFRNAKTYTPDPKAWIYYEASRSESAFRQLWNRITKTLEQAAARAEKAQAEDAMDAADAQAPEEPEAPPSVPAPISEASASPAPAPKKITIKLSRKGEKREASEGPARPVLKIKRARTGDESATPEASSEQPSEAPKAQAVDPSQTSEDPILPGETEMPLNPKKARSVLQMVSKTKEAAIFLYPIDPVRDQAPTYYDEIKHPMDLSKIDAKLKQGDYKTMGDFASDMRLMFANCRQFNPPGTVPAVMEQAVSRVWRREWSRAMVRKLEYSHKRSLQSMMSRLKQHPTGALFLYAVDPVALGIPTYFDVIPKENARDLTLISQKLRADQYDSIDALDADIRLMLHNCYTFNAGDERICDIAHAFEKAYQQEMYALRQAIEAFVAVLVALVRADAHEDAPELNVLATFPDNPFNIVKNGQANRVVFSIKTPPSTDRALTIESLTGAFLDPARADGHKKRVLRNMTTTRLKDAHLLTQGQTRQVPFDFFSEFKPQKLDVEFRAMVVDQSSSNKYNVPLYRGSVVVEEPPQSWFDLQLLSVYAIGLALVGLIGYVLFDKYGASLKRSLGTSAPKRKETVKPAAQPLGKDGKSYDEDWIPKQHNLRPRKPRGRK","length":1813,"molWeight":203467,"crc64":"B1A9DA1332B5D5FB","md5":"369350556F5A0B078366BFC874EBD2CC"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":2},"countByFeatureType":{"Transmembrane":1,"Domain":3,"Region":3,"Compositional bias":3},"uniParcId":"UPI0027A8216A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E819","uniProtkbId":"A0AAF0E819_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":11,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21507.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012299"}],"value":"mitochondrial processing peptidase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012299"}],"value":"3.4.24.64"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031018"}],"value":"Beta-MPP"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21507.1"}],"value":"MAS1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21507.1"}],"value":"MEQU1_000159"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00045757"}],"value":"Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon.","ecNumber":"3.4.24.55","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10096"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.","ecNumber":"3.4.24.64","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001098"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001947"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004173"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007261"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004447"}],"value":"Belongs to the peptidase M16 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Peptidase M16 N-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00675"}]},{"type":"Domain","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"Peptidase M16 C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF05193"}]},{"type":"Active site","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10096"}]},{"type":"Binding site","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10096"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10096"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21507.1"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023049"}],"id":"KW-0482","category":"Molecular function","name":"Metalloprotease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022670"}],"id":"KW-0645","category":"Molecular function","name":"Protease"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022946"}],"id":"KW-0809","category":"Domain","name":"Transit peptide"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21507.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21507.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD21507.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0E819","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004222","properties":[{"key":"GoTerm","value":"F:metalloendopeptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0009003","properties":[{"key":"GoTerm","value":"F:signal peptidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006508","properties":[{"key":"GoTerm","value":"P:proteolysis"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"FunFam","id":"3.30.830.10:FF:000002","properties":[{"key":"EntryName","value":"Mitochondrial-processing peptidase subunit beta"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.830.10:FF:000001","properties":[{"key":"EntryName","value":"Mitochondrial-processing peptidase subunit beta, mitochondrial"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.830.10","properties":[{"key":"EntryName","value":"Metalloenzyme, LuxS/M16 peptidase-like"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011249","properties":[{"key":"EntryName","value":"Metalloenz_LuxS/M16"}]},{"database":"InterPro","id":"IPR050361","properties":[{"key":"EntryName","value":"MPP/UQCRC_Complex"}]},{"database":"InterPro","id":"IPR011765","properties":[{"key":"EntryName","value":"Pept_M16_N"}]},{"database":"InterPro","id":"IPR001431","properties":[{"key":"EntryName","value":"Pept_M16_Zn_BS"}]},{"database":"InterPro","id":"IPR007863","properties":[{"key":"EntryName","value":"Peptidase_M16_C"}]},{"database":"PANTHER","id":"PTHR11851:SF149","properties":[{"key":"EntryName","value":"GH01077P"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11851","properties":[{"key":"EntryName","value":"METALLOPROTEASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00675","properties":[{"key":"EntryName","value":"Peptidase_M16"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05193","properties":[{"key":"EntryName","value":"Peptidase_M16_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF63411","properties":[{"key":"EntryName","value":"LuxS/MPP-like metallohydrolase"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00143","properties":[{"key":"EntryName","value":"INSULINASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSARLFLANSIKGNLRVPLASRSLATAATLQVGPRKRPGANVQPLTQVTMLPNGLTVATESNPSAQTATVGAWIDAGSRSECARTNGTAHFLEHMAFKGTHNRSQHGLELEVENLGAHLNAYTSREQTVFYAKSFRQDVDKAVDIISDILQNSKLDATAIERERDVILREQEEVDKQVEEVVFDHLHAVAFQSQALGRTILGPKENILSINRDDLSNYIQSKYTADRMVLVGAGGVEHDALVKLAEKHFSGLPVSQNPIKLGENQYEPSRFIGSEVRIRDDTSSTVNVAIAVEGASWKSPDYFPMLVLQSIFGNWDRSLGSSPLLSSRLSHIISSNNLANSFMHFSTSYSDTGLWGVYLVSENHMNLDDLVHFTLKEWQRASTGPAPAEVERAKSQLKASLLLGLDGTTAIAEDIGRQLVTTGKRFTPHEIEAAIDRVTPGEIQRVAQKYLWDKDIALAATGRVEGLLDYNRIRADMSTLLY","length":482,"molWeight":53065,"crc64":"848D972254AAD3B5","md5":"69D4C69375D39A884748EB2C6480CA99"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":2,"Active site":1,"Binding site":2},"uniParcId":"UPI00279DF015"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E850","uniProtkbId":"A0AAF0E850_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-05-29","entryVersion":8,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21552.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013152"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"value":"Transketolase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013152"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"value":"2.2.1.1"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21552.1"}],"value":"TKL1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21552.1"}],"value":"MEQU1_000205"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"value":"Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10508"},{"database":"ChEBI","id":"CHEBI:57483"},{"database":"ChEBI","id":"CHEBI:57737"},{"database":"ChEBI","id":"CHEBI:58273"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"2.2.1.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049473"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Ca(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001913"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29108"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Co(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001941"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:48828"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}},{"name":"Ca(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29108"}},{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}},{"name":"Co(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:48828"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"value":"Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+)."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-4"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-4"}],"value":"Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+)."}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001936"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"thiamine diphosphate","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-3"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:58937"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-3"}],"value":"Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004959"}],"value":"Carbohydrate degradation; pentose phosphate pathway"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007131"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"value":"Belongs to the transketolase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Transketolase-like pyrimidine-binding","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00861"}]},{"type":"Active site","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-1"}]},{"type":"Binding site","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78346"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-2"}],"ligand":{"name":"D-ribose 5-phosphate","id":"ChEBI:CHEBI:78346","label":"(ligand shared between dimeric partners)"}},{"type":"Binding site","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58937"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-3"}],"ligand":{"name":"thiamine diphosphate","id":"ChEBI:CHEBI:58937"}},{"type":"Binding site","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58937"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-3"}],"ligand":{"name":"thiamine diphosphate","id":"ChEBI:CHEBI:58937"}},{"type":"Binding site","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-4"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58937"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-3"}],"ligand":{"name":"thiamine diphosphate","id":"ChEBI:CHEBI:58937"}},{"type":"Binding site","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-4"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58937"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-3"}],"ligand":{"name":"thiamine diphosphate","id":"ChEBI:CHEBI:58937"}},{"type":"Binding site","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-4"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420"}},{"type":"Binding site","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78346"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-2"}],"ligand":{"name":"D-ribose 5-phosphate","id":"ChEBI:CHEBI:78346","label":"(ligand shared between dimeric partners)"}},{"type":"Binding site","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58937"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-3"}],"ligand":{"name":"thiamine diphosphate","id":"ChEBI:CHEBI:58937"}},{"type":"Binding site","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78346"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-2"}],"ligand":{"name":"D-ribose 5-phosphate","id":"ChEBI:CHEBI:78346","label":"(ligand shared between dimeric partners)"}},{"type":"Binding site","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":388,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78346"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-2"}],"ligand":{"name":"D-ribose 5-phosphate","id":"ChEBI:CHEBI:78346","label":"(ligand shared between dimeric partners)"}},{"type":"Binding site","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58937"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-3"}],"ligand":{"name":"thiamine diphosphate","id":"ChEBI:CHEBI:58937"}},{"type":"Binding site","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78346"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-2"}],"ligand":{"name":"D-ribose 5-phosphate","id":"ChEBI:CHEBI:78346","label":"(ligand shared between dimeric partners)"}},{"type":"Binding site","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":478,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78346"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-2"}],"ligand":{"name":"D-ribose 5-phosphate","id":"ChEBI:CHEBI:78346","label":"(ligand shared between dimeric partners)"}},{"type":"Binding site","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78346"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-2"}],"ligand":{"name":"D-ribose 5-phosphate","id":"ChEBI:CHEBI:78346","label":"(ligand shared between dimeric partners)"}},{"type":"Binding site","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:78346"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-2"}],"ligand":{"name":"D-ribose 5-phosphate","id":"ChEBI:CHEBI:78346","label":"(ligand shared between dimeric partners)"}},{"type":"Site","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Important for catalytic activity","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-5"}]},{"type":"Site","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Important for catalytic activity","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-5"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-4"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-4"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023052"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR605478-3"}],"id":"KW-0786","category":"Ligand","name":"Thiamine pyrophosphate"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004996"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21552.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21552.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD21552.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0E850","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004802","properties":[{"key":"GoTerm","value":"F:transketolase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006098","properties":[{"key":"GoTerm","value":"P:pentose-phosphate shunt"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd07033","properties":[{"key":"EntryName","value":"TPP_PYR_DXS_TK_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd02012","properties":[{"key":"EntryName","value":"TPP_TK"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.920:FF:000003","properties":[{"key":"EntryName","value":"Transketolase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000003","properties":[{"key":"EntryName","value":"Transketolase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.970:FF:000004","properties":[{"key":"EntryName","value":"Transketolase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.920","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.970","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR029061","properties":[{"key":"EntryName","value":"THDP-binding"}]},{"database":"InterPro","id":"IPR009014","properties":[{"key":"EntryName","value":"Transketo_C/PFOR_II"}]},{"database":"InterPro","id":"IPR055152","properties":[{"key":"EntryName","value":"Transketolase-like_C_2"}]},{"database":"InterPro","id":"IPR005475","properties":[{"key":"EntryName","value":"Transketolase-like_Pyr-bd"}]},{"database":"InterPro","id":"IPR005478","properties":[{"key":"EntryName","value":"Transketolase_bac-like"}]},{"database":"InterPro","id":"IPR020826","properties":[{"key":"EntryName","value":"Transketolase_BS"}]},{"database":"InterPro","id":"IPR049557","properties":[{"key":"EntryName","value":"Transketolase_CS"}]},{"database":"InterPro","id":"IPR033247","properties":[{"key":"EntryName","value":"Transketolase_fam"}]},{"database":"InterPro","id":"IPR005474","properties":[{"key":"EntryName","value":"Transketolase_N"}]},{"database":"NCBIfam","id":"TIGR00232","properties":[{"key":"EntryName","value":"tktlase_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43522","properties":[{"key":"EntryName","value":"TRANSKETOLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43522:SF2","properties":[{"key":"EntryName","value":"TRANSKETOLASE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02779","properties":[{"key":"EntryName","value":"Transket_pyr"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22613","properties":[{"key":"EntryName","value":"Transketolase_C_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00456","properties":[{"key":"EntryName","value":"Transketolase_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00861","properties":[{"key":"EntryName","value":"Transket_pyr"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52518","properties":[{"key":"EntryName","value":"Thiamin diphosphate-binding fold (THDP-binding)"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF52922","properties":[{"key":"EntryName","value":"TK C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00801","properties":[{"key":"EntryName","value":"TRANSKETOLASE_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00802","properties":[{"key":"EntryName","value":"TRANSKETOLASE_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVFTPTDVDLKAINTIRTLAADIVAKSKSGHPGAPMGLAPLAHLLWSRVITCDPKDSKWLNRDRFVLSNGHACALQYIMLHLMGYQVTMDDLKAFRQLNSKTPGHPEANHTDGVEVTTGPLGQGFATAVGLAIAERNAAAAFNKEGFELFNNYTYTILGDGCMQEGVASEAASLAGHLGLYNLIAFYDDNSVTIDGDTNVSFTEDVTKRFESYGWNVIPIEDGDNDIKSVFEAIEKAHSEKIKPTLISIKTTIGFGSKNQGTASTHGAPLKADDIEQLKEKFGFDPKETFVVPDEVAKAYASYAQRGAEKHAEWTKMFEEYGKKYEKEHSEILRRAAHKLPDGWEKCLPRYQPSDKPVATRKLSEMVLQEISSQVPEILGGSADLTGSNLTRWAEATDFQNPKLEIGNYAGRYLRYGVREHAMGAIMNGLHAYGLHIPTAGTFLNFVTYAWGAVRLSSLSHFQVIWVATHDSIGLGEDGPTHQPIEVAAALRALPNMDYWRPADGNEVSAAYKVALESPTTPSVLSLTRQNLPHLDGSSIEKASQGGYVVMEVPDAAITLVSTGSEVSICRDAAVKLNEQGIKARLVSLPCFSVFDKQPLDYRLSVLPSGHPILSVEAYSTLGWGKYAHVHHGINAFGVSAPYQQAYEHFHMTDKDVAEKAAKVVEYYKSMDQKLYSPVEVEAHFNP","length":687,"molWeight":75359,"crc64":"D06F58E32EF4AB7D","md5":"6E8525E9D767077296B44EE58D0FFB00"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":6,"PATHWAY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Active site":1,"Binding site":17,"Site":2},"uniParcId":"UPI0027A955BF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E8S8","uniProtkbId":"A0AAF0E8S8_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-05-29","entryVersion":9,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21837.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024074"}],"value":"alcohol dehydrogenase (NADP(+))"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024074"}],"value":"1.1.1.2"}]}},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21837.1"}],"value":"MEQU1_000493"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00024947"}],"value":"Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:15937"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15734"},{"database":"ChEBI","id":"CHEBI:17478"},{"database":"ChEBI","id":"CHEBI:57783"},{"database":"ChEBI","id":"CHEBI:58349"}],"ecNumber":"1.1.1.2","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050997"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:15938"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050997"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:15939"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00050997"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601765-1"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601765-1"}],"value":"Binds 1 zinc ion per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011738"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011814"}],"value":"Interacts with coenzyme Q"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006885"}],"value":"Belongs to the COQ10 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006217"}],"value":"Belongs to the beta-class carbonic anhydrase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008072"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361277"}],"value":"Belongs to the zinc-containing alcohol dehydrogenase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"Enoyl reductase (ER)","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00829"}]},{"type":"Binding site","location":{"start":{"value":623,"modifier":"EXACT"},"end":{"value":623,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601765-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":625,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601765-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":679,"modifier":"EXACT"},"end":{"value":679,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601765-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":682,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601765-1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601765-1"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022857"}],"id":"KW-0521","category":"Ligand","name":"NADP"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21837.1"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"PIRSR","id":"PIRSR601765-1"}],"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21837.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21837.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD21837.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0E8S8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:GOC"}]},{"database":"GO","id":"GO:0008106","properties":[{"key":"GoTerm","value":"F:alcohol dehydrogenase (NADP+) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004089","properties":[{"key":"GoTerm","value":"F:carbonate dehydratase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0048039","properties":[{"key":"GoTerm","value":"F:ubiquinone binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd05283","properties":[{"key":"EntryName","value":"CAD1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd07813","properties":[{"key":"EntryName","value":"COQ10p_like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000158","properties":[{"key":"EntryName","value":"Zinc-binding alcohol dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.530.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1050.10","properties":[{"key":"EntryName","value":"Carbonic anhydrase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.180.10","properties":[{"key":"EntryName","value":"Medium-chain alcohol dehydrogenases, catalytic domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013149","properties":[{"key":"EntryName","value":"ADH-like_C"}]},{"database":"InterPro","id":"IPR013154","properties":[{"key":"EntryName","value":"ADH-like_N"}]},{"database":"InterPro","id":"IPR002328","properties":[{"key":"EntryName","value":"ADH_Zn_CS"}]},{"database":"InterPro","id":"IPR047109","properties":[{"key":"EntryName","value":"CAD-like"}]},{"database":"InterPro","id":"IPR001765","properties":[{"key":"EntryName","value":"Carbonic_anhydrase"}]},{"database":"InterPro","id":"IPR036874","properties":[{"key":"EntryName","value":"Carbonic_anhydrase_sf"}]},{"database":"InterPro","id":"IPR044996","properties":[{"key":"EntryName","value":"COQ10-like"}]},{"database":"InterPro","id":"IPR005031","properties":[{"key":"EntryName","value":"COQ10_START"}]},{"database":"InterPro","id":"IPR019182","properties":[{"key":"EntryName","value":"Cytochrome_b-c1_su10_fun"}]},{"database":"InterPro","id":"IPR020843","properties":[{"key":"EntryName","value":"ER"}]},{"database":"InterPro","id":"IPR011032","properties":[{"key":"EntryName","value":"GroES-like_sf"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR023393","properties":[{"key":"EntryName","value":"START-like_dom_sf"}]},{"database":"PANTHER","id":"PTHR42683","properties":[{"key":"EntryName","value":"ALDEHYDE REDUCTASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08240","properties":[{"key":"EntryName","value":"ADH_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00107","properties":[{"key":"EntryName","value":"ADH_zinc_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03364","properties":[{"key":"EntryName","value":"Polyketide_cyc"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00484","properties":[{"key":"EntryName","value":"Pro_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09796","properties":[{"key":"EntryName","value":"QCR10"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00829","properties":[{"key":"EntryName","value":"PKS_ER"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00947","properties":[{"key":"EntryName","value":"Pro_CA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55961","properties":[{"key":"EntryName","value":"Bet v1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53056","properties":[{"key":"EntryName","value":"beta-carbonic anhydrase, cab"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50129","properties":[{"key":"EntryName","value":"GroES-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00059","properties":[{"key":"EntryName","value":"ADH_ZINC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSDFSQPPSCAGRRAAPYTSEQLYAIVADVDAYKEFLPYCLDSRVLGPSSPRATQAEPEATRVVDAELVIGFSALRESYVSEVSMRPHEWVKAKAKPSPLFKGLETAWYFRTLPKMPHIQRPQTEVTFTLAFAFSSPMYAAIAGQVFQKLSSSMIDAMPKGYAIHDTKNWTDFKVIDFELKTPEDDDVEVSITHCGICGSDLHTVSGGWGPLSVPACIPGHEIVGHVTQVGKNVKVIKVGDRVGIGAQVGSCMNCHPCKHDNENYCIGDGKGHMVDTYNSHWPDGSIAQGGYSTAIRAHQQFVFPIPEGLKSEHAAPMLCAGLTVYSPLYRNKVGPGMRVAIVGIGGLGHFGVMFAKAMGADVVAISHSASKEQDALKMGASKFVSTKEDPKWAEKFKTEPFDLIINTASSSAVDVPGMISSLKPEGRLVCVGMPEDEIKLRVQDLAMRSALLGSSHIGNKIEALSMLKLAAEKNVEPWIELVDMKDCSKAIERVSKGDTRESSPVCDSFLMFRPSPAAMGAFRATARAAFLKPSFQPHVGTMWVPSLFFWGASAGVLVTLALSGVPLFKKDVLLNTPVPIRAITETLLDRNASWSQEFITQQPDLAEALRGGQHPKVFWIGCSDSRVPESVVCNARPGELFVLRNVANQFHTYDDSAVSALTFAVQALGVEHVIVVGHTSCGGVAAAVKQVLHEQEDDFEPLPASALSRHLTPLTELARYLRARVRERHTIPGPEMQERLVPLLTEASVRKQIQNIVDHPVVQDNWQGKVSPLNGKVNPRVKIHGWIHNIHTGRLLDLNITVSPPPLPDTVN","length":813,"molWeight":88624,"crc64":"EB1BCD6F1A9538BD","md5":"FDF5AE85D94903F32F553945D92769DC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":2,"SIMILARITY":3},"countByFeatureType":{"Domain":1,"Binding site":4},"uniParcId":"UPI00279B0AD0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E8Z2","uniProtkbId":"A0AAF0E8Z2_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":10,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21942.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03005"}],"value":"Eukaryotic translation initiation factor 3 subunit F"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03005"}],"value":"eIF3f"}]}},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21942.1"}],"value":"MEQU1_000602"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03005"}],"value":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03005"}],"value":"Component of the eukaryotic translation initiation factor 3 (eIF-3) complex"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03005"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009802"}],"value":"Belongs to the MBF1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03005"}],"value":"Belongs to the eIF-3 subunit F family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01182"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"HTH cro/C1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50943"}]},{"type":"Domain","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":553,"modifier":"EXACT"}},"description":"N-acetyltransferase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51186"}]},{"type":"Domain","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":789,"modifier":"EXACT"}},"description":"MPN","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50249"}]},{"type":"DNA binding","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"H-T-H motif","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00257"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":816,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00532"}],"id":"KW-0012","category":"Molecular function","name":"Acyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03005"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00257"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022540"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03005"}],"id":"KW-0396","category":"Molecular function","name":"Initiation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022917"},{"evidenceCode":"ECO:0000256","source":"HAMAP-Rule","id":"MF_03005"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00257"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00257"}],"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00532"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21942.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21942.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD21942.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0E8Z2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0016282","properties":[{"key":"GoTerm","value":"C:eukaryotic 43S preinitiation complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0033290","properties":[{"key":"GoTerm","value":"C:eukaryotic 48S preinitiation complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0071541","properties":[{"key":"GoTerm","value":"C:eukaryotic translation initiation factor 3 complex, eIF3m"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016407","properties":[{"key":"GoTerm","value":"F:acetyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008233","properties":[{"key":"GoTerm","value":"F:peptidase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003743","properties":[{"key":"GoTerm","value":"F:translation initiation factor activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0031369","properties":[{"key":"GoTerm","value":"F:translation initiation factor binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0001732","properties":[{"key":"GoTerm","value":"P:formation of cytoplasmic translation initiation complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0006355","properties":[{"key":"GoTerm","value":"P:regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd00093","properties":[{"key":"EntryName","value":"HTH_XRE"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd08064","properties":[{"key":"EntryName","value":"MPN_eIF3f"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.630.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.140.10","properties":[{"key":"EntryName","value":"Cytidine Deaminase, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.260.40","properties":[{"key":"EntryName","value":"lambda repressor-like DNA-binding domains"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_03005","properties":[{"key":"EntryName","value":"eIF3f"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016181","properties":[{"key":"EntryName","value":"Acyl_CoA_acyltransferase"}]},{"database":"InterPro","id":"IPR001387","properties":[{"key":"EntryName","value":"Cro/C1-type_HTH"}]},{"database":"InterPro","id":"IPR027531","properties":[{"key":"EntryName","value":"eIF3f"}]},{"database":"InterPro","id":"IPR024969","properties":[{"key":"EntryName","value":"EIF3F/CSN6-like_C"}]},{"database":"InterPro","id":"IPR000182","properties":[{"key":"EntryName","value":"GNAT_dom"}]},{"database":"InterPro","id":"IPR000555","properties":[{"key":"EntryName","value":"JAMM/MPN+_dom"}]},{"database":"InterPro","id":"IPR010982","properties":[{"key":"EntryName","value":"Lambda_DNA-bd_dom_sf"}]},{"database":"InterPro","id":"IPR013729","properties":[{"key":"EntryName","value":"MBF1_N"}]},{"database":"InterPro","id":"IPR037518","properties":[{"key":"EntryName","value":"MPN"}]},{"database":"PANTHER","id":"PTHR10540:SF6","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10540","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00583","properties":[{"key":"EntryName","value":"Acetyltransf_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01381","properties":[{"key":"EntryName","value":"HTH_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01398","properties":[{"key":"EntryName","value":"JAB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08523","properties":[{"key":"EntryName","value":"MBF1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13012","properties":[{"key":"EntryName","value":"MitMem_reg"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00530","properties":[{"key":"EntryName","value":"HTH_XRE"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00232","properties":[{"key":"EntryName","value":"JAB_MPN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55729","properties":[{"key":"EntryName","value":"Acyl-CoA N-acyltransferases (Nat)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47413","properties":[{"key":"EntryName","value":"lambda repressor-like DNA-binding domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51186","properties":[{"key":"EntryName","value":"GNAT"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50943","properties":[{"key":"EntryName","value":"HTH_CROC1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50249","properties":[{"key":"EntryName","value":"MPN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASDESKKKTKKQKLEKDTHEKQASTLKKTVTLETVQSVVAELSKHNDKVALTDVIEKIASQYHLNAKDVKSRLLKKIPPTYLPSNHIRTMSAWDQTVVIGRKARPAGSSSSGPRGPTALERAKQVGAVTALDRKTAAGHNKAHQGTDHQRIAKLDREDDVAPPPKVSASVGKIIGQSRQAKGMTQKDLAVKINEKPSVIQEYESGKAIPSPQILAKMERNLGVKLRAVGDMTVSGEPPGNQAPALDVPPLTCDELLSLLLSNEFDVLVREFARLNLDTACATAFQPMRDDELEMVGIWVIQSVFHQALSPHSTFVEFFDGIKARFVIGFTEVYERKGSFSDIFEQMILASLSPYQVMVAKAYELSSDMHDCIFELLEANMRAMYEQVGIWDPDAKRAELQHKTSRFLLVLDTPTKDAARRRSPRTGSHAVQLLGFTMWRYDVDETNDDDISADPNDDIVEVTYWYVATPDNSYEVQVNAAFRGHKIGTAMLTILEQLAWKAGMRKVALTVFRANEAARAFYRRCGYTVDATSPDFGQEDVDTHYIILSKPMNNRFRNINDADNPLLHCEMNQHTLVSSDNCMAKVAERERGDRAAYRSDDHVALGEEGSRRPTFFIRDSMAGQNTFASSSALHLSFPPAASGVFHSRSITGVKVHPVALFSILDHFLRRDASQPRVIGTLLGTRSENEVEIRNCFAVPHGESQDPWQIHLDAEHHRRMLDLHLRVCPEEVVLGWYSTNPELNANSALIQDHYSRETAPHQAIHLTLNTNVADEKNGLGVQCYVSALLGATWKAEDCVFVSLPTTLLTTSPEQTALRFLSQEKREMLTDLDALKASLEQVQAQLERVLTYVRKVLSGELEGDKAVGRYLSDTISVVPVGLKGDELSALFNSHLQDVFMVSYLANMVSTQADLSARLALLQ","length":920,"molWeight":102371,"crc64":"4AC979C256598922","md5":"4EE1265A3F835A70190BC5EA785AD1F5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":2,"CAUTION":1},"countByFeatureType":{"Domain":3,"DNA binding":1,"Region":1,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI0027A1BDB7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E957","uniProtkbId":"A0AAF0E957_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":11,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22047.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096864"}],"value":"Double-stranded nucleic acid 5'-3' helicase Upf1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044969"}],"value":"5.6.2.3"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00066581"}],"value":"5.6.2.5"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00096814"}],"value":"Double-stranded nucleic acid 5'-3' helicase upf1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22047.1"}],"value":"NAM7"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22047.1"}],"value":"MEQU1_000709"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"5.6.2.3","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048954"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.","ecNumber":"5.6.2.3","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00093875"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.","ecNumber":"5.6.2.5","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00052583"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Zn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001947"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29105"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007913"}],"value":"Belongs to the DNA2/NAM7 helicase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01341"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Upf1","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51997"}]},{"type":"Region","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"C4","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01341"}]},{"type":"Region","location":{"start":{"value":820,"modifier":"EXACT"},"end":{"value":844,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022806"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22047.1"}],"id":"KW-0347","category":"Molecular function","name":"Helicase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01341"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023161"}],"id":"KW-0866","category":"Biological process","name":"Nonsense-mediated mRNA decay"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01341"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01341"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22047.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22047.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD22047.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0E957","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0043139","properties":[{"key":"GoTerm","value":"F:5'-3' DNA helicase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0032574","properties":[{"key":"GoTerm","value":"F:5'-3' RNA helicase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0000184","properties":[{"key":"GoTerm","value":"P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd21407","properties":[{"key":"EntryName","value":"1B_UPF1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd18039","properties":[{"key":"EntryName","value":"DEXXQc_UPF1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd18808","properties":[{"key":"EntryName","value":"SF1_C_Upf1"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21400","properties":[{"key":"EntryName","value":"ZBD_UPF1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000097","properties":[{"key":"EntryName","value":"Regulator of nonsense transcripts 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.30.230","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.140.1240","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR003593","properties":[{"key":"EntryName","value":"AAA+_ATPase"}]},{"database":"InterPro","id":"IPR045055","properties":[{"key":"EntryName","value":"DNA2/NAM7-like"}]},{"database":"InterPro","id":"IPR041679","properties":[{"key":"EntryName","value":"DNA2/NAM7-like_C"}]},{"database":"InterPro","id":"IPR041677","properties":[{"key":"EntryName","value":"DNA2/NAM7_AAA_11"}]},{"database":"InterPro","id":"IPR014001","properties":[{"key":"EntryName","value":"Helicase_ATP-bd"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR047187","properties":[{"key":"EntryName","value":"SF1_C_Upf1"}]},{"database":"InterPro","id":"IPR040812","properties":[{"key":"EntryName","value":"UPF1_1B_dom"}]},{"database":"InterPro","id":"IPR018999","properties":[{"key":"EntryName","value":"UPF1_CH/ZBD"}]},{"database":"PANTHER","id":"PTHR10887","properties":[{"key":"EntryName","value":"DNA2/NAM7 HELICASE FAMILY"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10887:SF364","properties":[{"key":"EntryName","value":"REGULATOR OF NONSENSE TRANSCRIPTS 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13086","properties":[{"key":"EntryName","value":"AAA_11"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF13087","properties":[{"key":"EntryName","value":"AAA_12"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18141","properties":[{"key":"EntryName","value":"UPF1_1B_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09416","properties":[{"key":"EntryName","value":"UPF1_Zn_bind"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00382","properties":[{"key":"EntryName","value":"AAA"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00487","properties":[{"key":"EntryName","value":"DEXDc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51997","properties":[{"key":"EntryName","value":"UPF1_CH_RICH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLHPESPLGDTVPECYTCGSKNPFMLGFLPARGSAVVMLLCRNPCNYAANTKEVEWDASQWAPLIENRSFLSWFVRIPSSATQRNAQPISSAQICKLENLWRDNEQATLEDVENPTKEQELTKTLVRYENAQQYYNIFRALLSVEEQYDKKLKESLIQHDVVVRWEAGKGRSLTLWLRLPQLESGEMRLGVGDELCVSYTGSLANTWKAVLKVSQFSPTSSMEVACDVPVYLQPPTECSTNFTVEFVWVGVTYSRMKKALNVFLNVRECMAPFLRKKLLGFPTGSEQVQFQEPKRYTAPGLPELNHSQVAAIKSVLSKPLSLIQGPPGTGKTVTSATIVYHLTQITKGKVLVCAPSNVAVDQLTEKIDRTGLKVVRLVSRTRETISSHVSFLSLHEQVSLIPPSPEMSRLINLRKKNGELSSDDEKRHRSLIFQMERKVLATADVICTTCSSSADRRLEGFEFSAVLIDEATQAVEPEILLPIVRGCKKLVLVGDHQQLGPVVMSNKVADAGMNLSLFERLILLGNQPRRLEVQYRMHPCLSEFPSNMFYDGMLQNGVTAQERLRRQDPIPWPIPTMPMMFYQNLGQEEISGSGTSFLNRTEASSVEKIITLFLKSGIVPEQIGVVTPYEGQRNFIINYMQTFGSLNKDLYRNVEVASVDAFQGREKDYIIVSCVRSNDRGGIGFLSDPRRLNVALTRARYGLIVIGNSKVLCKNPLWYHLLVHFKDRFALVEGALSNLQPSMIQFGRPPAERNKATPMQRMAVQKTETMDSLAMDPIHAPFRTLGGTAAPLREDMWSSLSLDAKSLSYTQSDRLAKKMAGGDDDLDSLDGFKSQASLDDDLDDNSMEGLLPTWSQNSVTTFT","length":863,"molWeight":96622,"crc64":"EBE7BB50B3E70E6E","md5":"5DD3F6F7099CD1EA138DA434A261A036"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":3,"COFACTOR":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Region":2},"uniParcId":"UPI00279F6451"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E9F1","uniProtkbId":"A0AAF0E9F1_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":11,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22197.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00019632"}],"value":"DNA topoisomerase 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012891"}],"value":"5.6.2.1"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00033297"}],"value":"DNA topoisomerase I"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22197.1"}],"value":"TOP1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22197.1"}],"value":"MEQU1_000861"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.","ecNumber":"5.6.2.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000213"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10130"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006645"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01382"}],"value":"Belongs to the type IB topoisomerase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":769,"modifier":"EXACT"}},"description":"DNA topoisomerase I eukaryotic-type","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00435"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":774,"modifier":"EXACT"},"end":{"value":807,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":755,"modifier":"EXACT"},"end":{"value":755,"modifier":"EXACT"}},"description":"O-(3'-phospho-DNA)-tyrosine intermediate","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10130"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01382"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023235"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01382"}],"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023029"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01382"}],"id":"KW-0799","category":"Molecular function","name":"Topoisomerase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22197.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22197.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119901","properties":[{"key":"ProteinId","value":"WFD22197.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0E9F1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003917","properties":[{"key":"GoTerm","value":"F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0007059","properties":[{"key":"GoTerm","value":"P:chromosome segregation"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006260","properties":[{"key":"GoTerm","value":"P:DNA replication"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006265","properties":[{"key":"GoTerm","value":"P:DNA topological change"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"1.10.132.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.170.11.10","properties":[{"key":"EntryName","value":"DNA Topoisomerase I, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.15.10","properties":[{"key":"EntryName","value":"Topoisomerase I, Chain A, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.41","properties":[{"key":"EntryName","value":"Yeast DNA topoisomerase - domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011010","properties":[{"key":"EntryName","value":"DNA_brk_join_enz"}]},{"database":"InterPro","id":"IPR013034","properties":[{"key":"EntryName","value":"DNA_topo_DNA_db_N_dom1"}]},{"database":"InterPro","id":"IPR013030","properties":[{"key":"EntryName","value":"DNA_topo_DNA_db_N_dom2"}]},{"database":"InterPro","id":"IPR001631","properties":[{"key":"EntryName","value":"TopoI"}]},{"database":"InterPro","id":"IPR025834","properties":[{"key":"EntryName","value":"TopoI_C_dom"}]},{"database":"InterPro","id":"IPR014711","properties":[{"key":"EntryName","value":"TopoI_cat_a-hlx-sub_euk"}]},{"database":"InterPro","id":"IPR014727","properties":[{"key":"EntryName","value":"TopoI_cat_a/b-sub_euk"}]},{"database":"InterPro","id":"IPR013500","properties":[{"key":"EntryName","value":"TopoI_cat_euk"}]},{"database":"InterPro","id":"IPR008336","properties":[{"key":"EntryName","value":"TopoI_DNA-bd_euk"}]},{"database":"InterPro","id":"IPR036202","properties":[{"key":"EntryName","value":"TopoI_DNA-bd_euk_N_sf"}]},{"database":"InterPro","id":"IPR013499","properties":[{"key":"EntryName","value":"TopoI_euk"}]},{"database":"InterPro","id":"IPR018521","properties":[{"key":"EntryName","value":"TopoIB_AS"}]},{"database":"InterPro","id":"IPR051062","properties":[{"key":"EntryName","value":"Topoisomerase_IB"}]},{"database":"PANTHER","id":"PTHR10290:SF3","properties":[{"key":"EntryName","value":"DNA TOPOISOMERASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10290","properties":[{"key":"EntryName","value":"DNA TOPOISOMERASE I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14370","properties":[{"key":"EntryName","value":"Topo_C_assoc"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01028","properties":[{"key":"EntryName","value":"Topoisom_I"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02919","properties":[{"key":"EntryName","value":"Topoisom_I_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00416","properties":[{"key":"EntryName","value":"EUTPISMRASEI"}]},{"database":"SMART","id":"SM00435","properties":[{"key":"EntryName","value":"TOPEUc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56349","properties":[{"key":"EntryName","value":"DNA breaking-rejoining enzymes"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56741","properties":[{"key":"EntryName","value":"Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00176","properties":[{"key":"EntryName","value":"TOPO_IB_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52038","properties":[{"key":"EntryName","value":"TOPO_IB_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRPKRQRSTPQYIKEEDSDEDVPLSLQASADDSDSDVPVSQQIQRRGTMKDNDSESEEDDQEEEEDDEESDDEDDVPLSGKKRKSPSRSKQKQSQSKTDIEGGGEQRWNTLVHKGPKFPEPYSSLPKDVMLRYDGHSVPLPPESEEVAMFYAVKLETQHASNPIFNKNFFEDFQSYLKRYPPKDGTKITKFEKLDFRDMFNYWRSLKEAEADRKKSMAPSARKAELAARKEADNQYKLCLVDGTPQKAGNVTVEPPGLFLGRGAHPKAGRVKTRILPEQITINHSADHPPPAPPAGHKWGEVVERKDVTWLALWRENINGSFKYVFLDASSNFKTESDREKFEKARRLDACVKQVRSDVLKNLTSKDRVDRMVATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCGHATLVPPNQLNLSFLGKDSMKFEETLTINNTDVYKNIAMFLKTDGTKVNGVLQKKGPDDPIFAAPKVRGEKMTPLPPDVVNQFLGKYMKGLSAKVFRTYNASATFQGLLDHTEDWLAARPTAQEREINPANLRIAYNEANRQVAILCNHQKTINHVTLGKSLDRTRDKIYGLKYDIYKEQQKLLTFHKAADLKKDYLPKDHPFAKQWALILKEPDLDKSRIQEHEENMIQAKKARMLSAFERQESERRYQEEQRKSTAKKIKDEVEDIKISKISTKAELDAELKKVDGHLKMLERERKSNKSEATSCNVPSVARKILSKYEAIKKQEAELLNKHNTSDVSLGTSKMNYIDPRITVAWLKKWDKKLQSLTPKNPKKGPTDSGTTNKKVKKEPIKSDSAAASEKMELDLEVMNIGQFFPMTLQKKFKWASFDDNNSPLSPNWTFVKNADQKMRKLSSAERK","length":866,"molWeight":98940,"crc64":"0A5A778B6A4C8090","md5":"8C8FAA17B7AF34D1FAFCFAD76092BD7D"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":3,"Active site":1},"uniParcId":"UPI0027A5A494"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E9I6","uniProtkbId":"A0AAF0E9I6_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-05-29","entryVersion":10,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21480.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044180"}],"value":"Histone H3-like centromeric protein CSE4"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044336"}],"value":"CENP-A homolog"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044234"}],"value":"CENPA homolog"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21480.1"}],"value":"PTH2"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21480.1"}],"value":"MEQU1_000132"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00043846"}],"value":"Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00044024"}],"value":"Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004584"}],"value":"Chromosome, centromere","id":"SL-0047"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010343"}],"value":"Belongs to the histone H3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":461,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"Core Histone H2A/H2B/H3","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF00125"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023328"}],"id":"KW-0137","category":"Cellular component","name":"Centromere"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022454"}],"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023269"}],"id":"KW-0544","category":"Cellular component","name":"Nucleosome core"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21480.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD21480.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119900","properties":[{"key":"ProteinId","value":"WFD21480.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0E9I6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0000775","properties":[{"key":"GoTerm","value":"C:chromosome, centromeric region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000786","properties":[{"key":"GoTerm","value":"C:nucleosome"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0030527","properties":[{"key":"GoTerm","value":"F:structural constituent of chromatin"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd22911","properties":[{"key":"EntryName","value":"HFD_H3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.20.10:FF:000087","properties":[{"key":"EntryName","value":"Probable histone 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.20.10","properties":[{"key":"EntryName","value":"Histone, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR018608","properties":[{"key":"EntryName","value":"Gti1/Pac2"}]},{"database":"InterPro","id":"IPR007125","properties":[{"key":"EntryName","value":"H2A/H2B/H3"}]},{"database":"InterPro","id":"IPR009072","properties":[{"key":"EntryName","value":"Histone-fold"}]},{"database":"InterPro","id":"IPR000164","properties":[{"key":"EntryName","value":"Histone_H3/CENP-A"}]},{"database":"PANTHER","id":"PTHR28027:SF1","properties":[{"key":"EntryName","value":"CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28027","properties":[{"key":"EntryName","value":"TRANSCRIPTIONAL REGULATOR MIT1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09729","properties":[{"key":"EntryName","value":"Gti1_Pac2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00125","properties":[{"key":"EntryName","value":"Histone"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00428","properties":[{"key":"EntryName","value":"H3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47113","properties":[{"key":"EntryName","value":"Histone-fold"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSATLDPPARPLALSNGSDRATPSSRASSISPPHVPSPQNQITWEPTPYRNTGRDIHIGERRPTYFGYIKTPADAILLLAACDLPDVPRDPRMEPPPRRISRRLLDDERAALIRSGSIFVWDEREAGMRRWTDGHCWSASRVSGCFLTYRELEMRKKNTENVKEAPRGNLYKPDGLIKQSFSITTASNRKLHVISYFRKNDVRMGLLQRVSKDPRITGRGPDSWNVQVDEEEFGELMTRESERLPHHVLMDNKQAPYAMDEKRAMKRSLSEDSSGPSSPTISDETEPVPRPYVVPRPVMAYPSYDRAYPRYPSINNNHAVRDEGMAMKRYRYDRSYSPPYPYYPEQRAWASRYDTPVHMSPITPPPLSSPVPVGYKPHPKPAPYAYNKSRPQLPPLQFPRASEAERGTLGALASLRADVSRYPPQPAAMSYKMIAQGPTQPRFAPVSAHVTTQEKKRRYKPGTVALREIRKYQRSTDLLISKLPFARVVREVADDFIEANYDSSASAVGLRWQSSAILALQEATEAYLVHLFEDANLCAIHAKRVTIMQRDIQLARRIRGVWGGMG","length":566,"molWeight":64209,"crc64":"61D0A67AD3EBEE31","md5":"E847A8F25ABF0E1BA6D46D459709F58E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":2},"uniParcId":"UPI0027A0F86F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAF0E9X0","uniProtkbId":"A0AAF0E9X0_9BASI","entryAudit":{"firstPublicDate":"2024-05-29","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2024-05-29","entryVersion":9,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Malassezia equina","taxonId":1381935,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22467.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"lineage":["Eukaryota","Fungi","Dikarya","Basidiomycota","Ustilaginomycotina","Malasseziomycetes","Malasseziales","Malasseziaceae","Malassezia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"}],"value":"non-specific serine/threonine protein kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012513"}],"value":"2.7.11.1"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22467.1"}],"value":"BUD32"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22467.1"}],"value":"MEQU1_001139"}]}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:17989"},{"database":"Rhea","id":"RHEA-COMP:9863"},{"database":"Rhea","id":"RHEA-COMP:11604"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29999"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:83421"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048679"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:46608"},{"database":"Rhea","id":"RHEA-COMP:11060"},{"database":"Rhea","id":"RHEA-COMP:11605"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30013"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:61977"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.11.1","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00047899"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10596"},{"database":"Rhea","id":"RHEA-COMP:10136"},{"database":"Rhea","id":"RHEA-COMP:20101"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:46858"},{"database":"ChEBI","id":"CHEBI:61978"},{"database":"ChEBI","id":"CHEBI:456216"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10028"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010630"}],"value":"Belongs to the protein kinase superfamily. BUD32 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"value":"Belongs to the protein kinase superfamily. Tyr protein kinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Protein kinase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50011"}]},{"type":"Active site","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10028"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP001214415"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022527"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22467.1"}],"id":"KW-0723","category":"Molecular function","name":"Serine/threonine-protein kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022694"}],"id":"KW-0819","category":"Biological process","name":"tRNA processing"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00159"}],"id":"KW-0829","category":"Molecular function","name":"Tyrosine-protein kinase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8IS3H32II2RLO","citationType":"submission","authors":["Coelho M.A."],"title":"Mating type loci evolution in Malassezia.","publicationDate":"MAR-2023","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22467.1"}],"value":"CBS 12830","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"WFD22467.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP119901","properties":[{"key":"ProteinId","value":"WFD22467.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAF0E9X0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP001214415","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000408","properties":[{"key":"GoTerm","value":"C:EKC/KEOPS complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004674","properties":[{"key":"GoTerm","value":"F:protein serine/threonine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0004713","properties":[{"key":"GoTerm","value":"F:protein tyrosine kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0070525","properties":[{"key":"GoTerm","value":"P:tRNA threonylcarbamoyladenosine metabolic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"FunFam","id":"3.30.200.20:FF:000201","properties":[{"key":"EntryName","value":"TP53-regulating kinase isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.200.20","properties":[{"key":"EntryName","value":"Phosphorylase Kinase, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.510.10","properties":[{"key":"EntryName","value":"Transferase(Phosphotransferase) domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR022495","properties":[{"key":"EntryName","value":"Bud32"}]},{"database":"InterPro","id":"IPR011009","properties":[{"key":"EntryName","value":"Kinase-like_dom_sf"}]},{"database":"InterPro","id":"IPR000719","properties":[{"key":"EntryName","value":"Prot_kinase_dom"}]},{"database":"InterPro","id":"IPR008266","properties":[{"key":"EntryName","value":"Tyr_kinase_AS"}]},{"database":"NCBIfam","id":"TIGR03724","properties":[{"key":"EntryName","value":"arch_bud32"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12209:SF0","properties":[{"key":"EntryName","value":"EKC_KEOPS COMPLEX SUBUNIT TP53RK"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12209","properties":[{"key":"EntryName","value":"NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00069","properties":[{"key":"EntryName","value":"Pkinase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56112","properties":[{"key":"EntryName","value":"Protein kinase-like (PK-like)"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50011","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_DOM"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00109","properties":[{"key":"EntryName","value":"PROTEIN_KINASE_TYR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDEPGGEAPVLQLLQAPDTCLVKQGAEAKVYRAVLWEDEAPLTFPDGRTETHHARSSTVLIKHRFFKRYRHPALSKSITAQRTISEARSLVRSARSGVHVPRLVFVDETRGLLGMEWIEGQSVRQWLGGVPEEGEEAKKEHPSEEEQLDIMNRIGEQLGRMHCADVIHGDLTTSNMMLRPDGQIVLIDFGLASVSSFWEDKAVDLYVLERAFASTHPASEPLFHRVLASYAAYTTEHTRGTKTKGERHVDGAWPHIYARLQEVRLRGRKRSMVG","length":274,"molWeight":30884,"crc64":"3082ECE7C7AC4644","md5":"2A4E829A4B724B671DB3357746E5AB1C"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":3,"SIMILARITY":2},"countByFeatureType":{"Domain":1,"Active site":1},"uniParcId":"UPI0027A1739F"}}]}