{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P9WES9","uniProtkbId":"LECAS_PSEFF","entryAudit":{"firstPublicDate":"2022-10-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-10-12","entryVersion":14,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34430202"}],"value":"Non-reducing polyketide synthase PFUR17_0229"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34430202"}],"value":"NR-PKS PFUR17_0229"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34430202"}],"value":"2.3.1.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34430202"}],"value":"Lecanoric acid synthase"}}]},"genes":[{"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"34430202"}],"value":"PFUR17_0229"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34430202"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34430202"}],"value":"Non-reducing polyketide synthase; part of a gene cluster that mediates the biosynthesis of a yet unidentified depside/depsidone compound (Probable). The first step in the pathway is performed by the PKS PFUR17_0229 that condenses 2 acetyl-CoA starter units with 6 malonyl-CoA units to produce lecanoric acid (LA), also known as orsellinate depside (PubMed:34430202). The biosynthesis occurs via the formation of 2 orsellinate intermediates fused together by the C-terminal thioesterase (TE) domain that finally releases lecanoric acid (PubMed:34430202). In addition to the PKS gene, the PFUR17 gene cluster contains closely linked genes encoding a cytochrome P-450 and a laccase (phenol oxidase), directly upstream and downstream respectively, so it is likely that lecanoric acid is an intermediate in a longer biosynthetic pathway (Probable)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"6 malonyl-CoA + 2 acetyl-CoA + 5 H(+) = o-orsellinate depside + 6 CO2 + 8 CoA + H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72467"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:57287"},{"database":"ChEBI","id":"CHEBI:57288"},{"database":"ChEBI","id":"CHEBI:57384"},{"database":"ChEBI","id":"CHEBI:57548"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34430202"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:72468"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34430202"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"pantetheine 4'-phosphate","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00258"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:47942"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34430202"}],"value":"Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34430202"}],"value":"The release of the polyketide chain from the non-reducing polyketide synthase is mediated by the thioesterase (TE) domain localized at the C-ter of the protein"}],"commentType":"DOMAIN"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2115,"modifier":"EXACT"}},"description":"Non-reducing polyketide synthase PFUR17_0229","featureId":"PRO_0000456486"},{"type":"Domain","location":{"start":{"value":367,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"Ketosynthase family 3 (KS3)","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01348"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34430202"}]},{"type":"Domain","location":{"start":{"value":1282,"modifier":"EXACT"},"end":{"value":1588,"modifier":"EXACT"}},"description":"PKS/mFAS DH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01363"}]},{"type":"Domain","location":{"start":{"value":1626,"modifier":"EXACT"},"end":{"value":1703,"modifier":"EXACT"}},"description":"Carrier 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00258"}]},{"type":"Domain","location":{"start":{"value":1742,"modifier":"EXACT"},"end":{"value":1819,"modifier":"EXACT"}},"description":"Carrier 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00258"}]},{"type":"Region","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"N-terminal acylcarrier protein transacylase (SAT) domain (SAT)","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34430202"}]},{"type":"Region","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":1218,"modifier":"EXACT"}},"description":"Malonyl-CoA:ACP transacylase (MAT) domain","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34430202"}]},{"type":"Region","location":{"start":{"value":1279,"modifier":"EXACT"},"end":{"value":1592,"modifier":"EXACT"}},"description":"Product template (PT) domain","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34430202"}]},{"type":"Region","location":{"start":{"value":1282,"modifier":"EXACT"},"end":{"value":1413,"modifier":"EXACT"}},"description":"N-terminal hotdog fold","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01363"}]},{"type":"Region","location":{"start":{"value":1441,"modifier":"EXACT"},"end":{"value":1588,"modifier":"EXACT"}},"description":"C-terminal hotdog fold","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01363"}]},{"type":"Region","location":{"start":{"value":1594,"modifier":"EXACT"},"end":{"value":1613,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1710,"modifier":"EXACT"},"end":{"value":1742,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1861,"modifier":"EXACT"},"end":{"value":2097,"modifier":"EXACT"}},"description":"Thioesterase (TE) domain","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34430202"}]},{"type":"Compositional bias","location":{"start":{"value":1718,"modifier":"EXACT"},"end":{"value":1733,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"For beta-ketoacyl synthase activity","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01348"}]},{"type":"Active site","location":{"start":{"value":674,"modifier":"EXACT"},"end":{"value":674,"modifier":"EXACT"}},"description":"For beta-ketoacyl synthase activity","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01348"}]},{"type":"Active site","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":713,"modifier":"EXACT"}},"description":"For beta-ketoacyl synthase activity","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01348"}]},{"type":"Active site","location":{"start":{"value":1315,"modifier":"EXACT"},"end":{"value":1315,"modifier":"EXACT"}},"description":"Proton acceptor; for dehydratase activity","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01363"}]},{"type":"Active site","location":{"start":{"value":1501,"modifier":"EXACT"},"end":{"value":1501,"modifier":"EXACT"}},"description":"Proton donor; for dehydratase activity","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01363"}]},{"type":"Modified residue","location":{"start":{"value":1663,"modifier":"EXACT"},"end":{"value":1663,"modifier":"EXACT"}},"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00258"}]},{"type":"Modified residue","location":{"start":{"value":1779,"modifier":"EXACT"},"end":{"value":1779,"modifier":"EXACT"}},"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00258"}]}],"keywords":[{"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"id":"KW-0596","category":"PTM","name":"Phosphopantetheine"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"30626017","citationType":"journal article","authors":["Calchera A.","Dal Grande F.","Bode H.B.","Schmitt I."],"citationCrossReferences":[{"database":"PubMed","id":"30626017"},{"database":"DOI","id":"10.3390/molecules24010203"}],"title":"Biosynthetic gene content of the 'Perfume Lichens' Evernia prunastri and Pseudevernia furfuracea.","publicationDate":"2019","journal":"Molecules","firstPage":"0","lastPage":"0","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"34430202","citationType":"journal article","authors":["Kealey J.T.","Craig J.P.","Barr P.J."],"citationCrossReferences":[{"database":"PubMed","id":"34430202"},{"database":"DOI","id":"10.1016/j.mec.2021.e00172"}],"title":"Identification of a lichen depside polyketide synthase gene by heterologous expression in Saccharomyces cerevisiae.","publicationDate":"2021","journal":"Metab. Eng. Commun.","firstPage":"e00172","lastPage":"e00172","volume":"13"},"referencePositions":["IDENTIFICATION","DOMAIN","FUNCTION","CATALYTIC ACTIVITY"]}],"uniProtKBCrossReferences":[{"database":"AlphaFoldDB","id":"P9WES9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P9WES9","properties":[{"key":"Description","value":"-"}]},{"database":"ESTHER","id":"pseff-p9wes9","properties":[{"key":"FamilyName","value":"Thioesterase"}]},{"database":"GO","id":"GO:0004315","properties":[{"key":"GoTerm","value":"F:3-oxoacyl-[acyl-carrier-protein] synthase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004312","properties":[{"key":"GoTerm","value":"F:fatty acid synthase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0031177","properties":[{"key":"GoTerm","value":"F:phosphopantetheine binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006633","properties":[{"key":"GoTerm","value":"P:fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0044550","properties":[{"key":"GoTerm","value":"P:secondary metabolite biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00833","properties":[{"key":"EntryName","value":"PKS"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.366.10:FF:000002","properties":[{"key":"EntryName","value":"Probable polyketide synthase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.1200.10:FF:000011","properties":[{"key":"EntryName","value":"Sterigmatocystin biosynthesis polyketide synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.70.3290","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.47.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.1200.10","properties":[{"key":"EntryName","value":"ACP-like"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.40.50.1820","properties":[{"key":"EntryName","value":"alpha/beta hydrolase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.366.10","properties":[{"key":"EntryName","value":"Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"3.10.129.110","properties":[{"key":"EntryName","value":"Polyketide synthase dehydratase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR029058","properties":[{"key":"EntryName","value":"AB_hydrolase_fold"}]},{"database":"InterPro","id":"IPR001227","properties":[{"key":"EntryName","value":"Ac_transferase_dom_sf"}]},{"database":"InterPro","id":"IPR036736","properties":[{"key":"EntryName","value":"ACP-like_sf"}]},{"database":"InterPro","id":"IPR014043","properties":[{"key":"EntryName","value":"Acyl_transferase_dom"}]},{"database":"InterPro","id":"IPR016035","properties":[{"key":"EntryName","value":"Acyl_Trfase/lysoPLipase"}]},{"database":"InterPro","id":"IPR014031","properties":[{"key":"EntryName","value":"KAS_C"}]},{"database":"InterPro","id":"IPR014030","properties":[{"key":"EntryName","value":"KAS_N"}]},{"database":"InterPro","id":"IPR018201","properties":[{"key":"EntryName","value":"Ketoacyl_synth_AS"}]},{"database":"InterPro","id":"IPR016036","properties":[{"key":"EntryName","value":"Malonyl_transacylase_ACP-bd"}]},{"database":"InterPro","id":"IPR020841","properties":[{"key":"EntryName","value":"PKS_Beta-ketoAc_synthase_dom"}]},{"database":"InterPro","id":"IPR042104","properties":[{"key":"EntryName","value":"PKS_dehydratase_sf"}]},{"database":"InterPro","id":"IPR049900","properties":[{"key":"EntryName","value":"PKS_mFAS_DH"}]},{"database":"InterPro","id":"IPR050091","properties":[{"key":"EntryName","value":"PKS_NRPS_Biosynth_Enz"}]},{"database":"InterPro","id":"IPR020806","properties":[{"key":"EntryName","value":"PKS_PP-bd"}]},{"database":"InterPro","id":"IPR009081","properties":[{"key":"EntryName","value":"PP-bd_ACP"}]},{"database":"InterPro","id":"IPR030918","properties":[{"key":"EntryName","value":"PT_fungal_PKS"}]},{"database":"InterPro","id":"IPR032088","properties":[{"key":"EntryName","value":"SAT"}]},{"database":"InterPro","id":"IPR001031","properties":[{"key":"EntryName","value":"Thioesterase"}]},{"database":"InterPro","id":"IPR016039","properties":[{"key":"EntryName","value":"Thiolase-like"}]},{"database":"NCBIfam","id":"TIGR04532","properties":[{"key":"EntryName","value":"PT_fungal_PKS"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43775","properties":[{"key":"EntryName","value":"FATTY ACID SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43775:SF37","properties":[{"key":"EntryName","value":"SI:DKEY-61P9.11"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00698","properties":[{"key":"EntryName","value":"Acyl_transf_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22621","properties":[{"key":"EntryName","value":"CurL-like_PKS_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00109","properties":[{"key":"EntryName","value":"ketoacyl-synt"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02801","properties":[{"key":"EntryName","value":"Ketoacyl-synt_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00550","properties":[{"key":"EntryName","value":"PP-binding"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF16073","properties":[{"key":"EntryName","value":"SAT"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00975","properties":[{"key":"EntryName","value":"Thioesterase"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00827","properties":[{"key":"EntryName","value":"PKS_AT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00825","properties":[{"key":"EntryName","value":"PKS_KS"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00823","properties":[{"key":"EntryName","value":"PKS_PP"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF47336","properties":[{"key":"EntryName","value":"ACP-like"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF53474","properties":[{"key":"EntryName","value":"alpha/beta-Hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52151","properties":[{"key":"EntryName","value":"FabD/lysophospholipase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55048","properties":[{"key":"EntryName","value":"Probable ACP-binding domain of malonyl-CoA ACP transacylase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53901","properties":[{"key":"EntryName","value":"Thiolase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50075","properties":[{"key":"EntryName","value":"CARRIER"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00606","properties":[{"key":"EntryName","value":"KS3_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52004","properties":[{"key":"EntryName","value":"KS3_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52019","properties":[{"key":"EntryName","value":"PKS_MFAS_DH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTTTSRVVLFGDQTVDPSPLIKQLCRHSTHSLTLQTFLQKTYFAVRQELAICEISDRANFPSFDSILALAETYSQSNESNEAVSTVLLCIAQLGLLLSREYNDNVINDSSCYSTTYLVGLCTGMLPAAALAFASSTTQLLELAPEVVRISVRLGLEASRRSAQIEKSHESWATLVPGIPLQEQRDILHRFHDVYPIPASKRAYISAESDSTTTISGPPSTLASLFSFSESLRNTRKISLPITAAFHAPHLGSSDTDKIIGSLSKGNEYHLRRDAVIISTSTGDQITGRSLGEALQQVVWDILREPLRWSTVTHAIAAKFRDQDAVLISAGPVRAANSLRREMTNAGVKIVDSYEMQPLQVSQSRNTSGDIAIVGVAGRLPGGETLEEIWENLEKGKDLHKEIPKDRFDVKTHCDPSGKIKNTTLTPYGCFLDRPGFFDARLFNMSPREAAQTDPAQRLLLLTTYEALEMSGYTPNGSPSSASDRIGTFFGQTLDDYREANASQNIDMYYVTGGIRAFGPGRLNYHFKWEGPSYCVDAACSSSALSVQMAMSSLRARECDTAVAGGTNILTGVDMFSGLSRGSFLSPTGSCKTFDDEADGYCRGEGVGSVVLKRLEDAIAEGDNIQAVIKSAATNHSAHAISITHPHAGTQQKLIRQVLREADVEADEIDYVEMHGTGTQAGDATEFTSVTKVLSDRTKDNPLHIGAVKANFGHAEAAAGTNSLIKILMMMRKNKIPPHVGIKGRINHKFPPLDKVNVSIDRALVAFKAHAKGDGKRRVLLNNFNATGGNTSLVLEDPPETVTEGEDPRTAWVVAVSAKTSNSFTQNQQRLLNYVESNPETQLQDLSYTTTARRMHHDTYRKAYAVESMDQLVRSMRKDLSSPSEPTAITGSSPSIFAFTGQGAQYLGMGRQLFETNTSFRQNILDFDRICVRQGLPSFKWLVTSSTSDESVPSPSESQLAMVSIAVALVSLWQSWGIVPSAVIGHSLGEYAALCVAGVLSVSDTLYLVGKRAEMMEKKCIANSHAMLAVQSGSELIQQIIHAEKISTCELACSNGPSNTVVSGTGKDINSLAEKLDDMGVKKTLLKLPYAFHSAQMDPILEDIRAIASNVEFLKPTVPIASTLLGSLVRDQGVITAEYLSRQTRQPVKFQEALYSLRSEGIAGDEALWIEVGAHPLCHSMVRSTLGLSPTKALPTLRRDEDCWSTISKSISNAYNSGAKFMWTEYHRDFRGALKLLELPSYAFDLKNYWIQHEGDWSLRKGEKMIASSTPTVPQQTFSTTCLQKVESETFTQDSASVAFSSRLAEPSLNTAVRGHLVNNVGLCPSSVYADVAFTAAWYIASRMAPSELVPAMDLSTMEVFRPLIVDKETSQILHVSASRKPGEQVVKVQISSQDMNGSKDHANCTVMYGDGQQWIDEWQLNAYLVQSRVDQLIQPVKPASVHRLLKEMIYRQFQTVVTYSKEYHNIDEIFMDCDLNETAANIRFQPTAGNGNFIYSPYWIDTVAHLAGFVLNASTKTPADTVFISHGWQSFRIAAPLSDEKTYRGYVRMQPIGTRGVMAGDVYIFDGDRIVVLCKGIKFQKMKRNILQSLLSTGHEETPPARPVPSKRTVQGSVTETKAAITPSIKAASGGFSNILETIASEVGIEVSEITDDGKISDLGVDSLLTISILGRLRSETGLDLPSSLFIAYPTVAQLRNFFLDKVATSQSVFDDEESEMSSSTAGSTPGSSTSHGNQNTTVTTPAEPDVVAILMSIIAREVGIDATEIQPSTPFADLGVDSLLTISILDSFKSEMRMSLAATFFHENPTFTDVQKALGVPSMPQKSLKMPSEFPEMNMGPSNQSVRSKSSILQGRPASNRPALFLLPDGAGSMFSYISLPALPSGVPVYGLDSPFHNSPKDYTVSFEEVASIFIKEIRAIQPRGPYMLGGWSLGGILAYEASRQLIAQGETITNLIMIDSPCPGTLPPLPSPTLNLLEKAGIFDGLSASSGPITERTRLHFLGSVRALENYTVKPIPADRSPGKVTVIWAQDGVLEGREDVGGEEWMADSSGGDANADMEKAKQWLTGKRTSFGPSGWDKLTGAEVQCHVVGGNHFSIMFPPKIEAVAVAMATGLPA","length":2115,"molWeight":230207,"crc64":"A232B37F91D55D2D","md5":"54455A592A9E91A52753F70E16163B6F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"DOMAIN":2},"countByFeatureType":{"Chain":1,"Domain":4,"Region":8,"Compositional bias":1,"Active site":5,"Modified residue":2},"uniParcId":"UPI00210F2345"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7T4PVM1","uniProtkbId":"A0A7T4PVM1_PSEFF","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-06-02","entryVersion":15,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97237.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10009"}],"value":"Glyceraldehyde-3-phosphate dehydrogenase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10009"}],"value":"1.2.1.12"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10009"}],"value":"phosphorylating"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97237.1"}],"value":"GAPDH"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:10300"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:57604"},{"database":"ChEBI","id":"CHEBI:57945"},{"database":"ChEBI","id":"CHEBI:59776"}],"ecNumber":"1.2.1.12","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10009"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004869"}],"value":"Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00011881"}],"value":"Homotetramer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004514"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007406"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000397"}],"value":"Belongs to the glyceraldehyde-3-phosphate dehydrogenase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM00846"}]},{"type":"Active site","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10009"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97237.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97237.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022703"}],"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023152"}],"id":"KW-0324","category":"Biological process","name":"Glycolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023027"}],"id":"KW-0520","category":"Ligand","name":"NAD"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023002"}],"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022799"}],"id":"KW-0702","category":"PTM","name":"S-nitrosylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"33242583","citationType":"journal article","authors":["Garrido-Benavent I.","Perez-Ortega S.","de Los Rios A.","Mayrhofer H.","Fernandez-Mendoza F."],"citationCrossReferences":[{"database":"PubMed","id":"33242583"}],"title":"Neogene speciation and Pleistocene expansion of the genus Pseudephebe (Parmeliaceae, lichenized fungi) involving multiple colonizations of Antarctica.","publicationDate":"2020","journal":"Mol. Phylogenet. Evol.","firstPage":"0","lastPage":"0","volume":"107020"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97237.1"}],"value":"IGB802","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97237.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT416175","properties":[{"key":"ProteinId","value":"QQC97237.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7T4PVM1","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00109","properties":[{"key":"RectionId","value":"UER00184"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0004365","properties":[{"key":"GoTerm","value":"F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0051287","properties":[{"key":"GoTerm","value":"F:NAD binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006096","properties":[{"key":"GoTerm","value":"P:glycolytic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"CDD","id":"cd18126","properties":[{"key":"EntryName","value":"GAPDH_I_C"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd05214","properties":[{"key":"EntryName","value":"GAPDH_I_N"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.360.10:FF:000001","properties":[{"key":"EntryName","value":"Glyceraldehyde-3-phosphate dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.720:FF:000319","properties":[{"key":"EntryName","value":"Glyceraldehyde-3-phosphate dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.360.10","properties":[{"key":"EntryName","value":"Dihydrodipicolinate Reductase, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR020831","properties":[{"key":"EntryName","value":"GlycerAld/Erythrose_P_DH"}]},{"database":"InterPro","id":"IPR020830","properties":[{"key":"EntryName","value":"GlycerAld_3-P_DH_AS"}]},{"database":"InterPro","id":"IPR020829","properties":[{"key":"EntryName","value":"GlycerAld_3-P_DH_cat"}]},{"database":"InterPro","id":"IPR020828","properties":[{"key":"EntryName","value":"GlycerAld_3-P_DH_NAD(P)-bd"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"PANTHER","id":"PTHR10836","properties":[{"key":"EntryName","value":"GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10836:SF76","properties":[{"key":"EntryName","value":"GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02800","properties":[{"key":"EntryName","value":"Gp_dh_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00044","properties":[{"key":"EntryName","value":"Gp_dh_N"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00078","properties":[{"key":"EntryName","value":"G3PDHDRGNASE"}]},{"database":"SMART","id":"SM00846","properties":[{"key":"EntryName","value":"Gp_dh_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55347","properties":[{"key":"EntryName","value":"Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00071","properties":[{"key":"EntryName","value":"GAPDH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"KGTIEVKGSDLVVNGQTVKFYTEKDPANIPWKDTGAYYIVESTGVFTTTEKAKAHLKGGAKKVVISAPSADAAMFVMGVNEKEYKSDIEIISNASCTTNCLAPLAKVMHDNFTIIEGLMTTIHSYTATQKTVDGPSSKDWRGGRTAAQNIIPSSTGAAKAVGKVIPSLNGKLTGMSMRVPTSNVSVVDLTCRLEKSVTYDQIKETMKKASEGELKGIMSYSEDALVSTDLNGDNHSCIFDATAG","length":244,"molWeight":25986,"crc64":"AB4A41837581786E","md5":"59444BCE10CB552E1F9156FB271ED102"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Domain":1,"Active site":1,"Non-terminal residue":2},"uniParcId":"UPI00193675AF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7T4U5H1","uniProtkbId":"A0A7T4U5H1_PSEFF","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-06-02","entryVersion":19,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97230.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU365012"}],"value":"DNA replication licensing factor MCM7"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU365012"}],"value":"3.6.4.12"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97230.1"}],"value":"Mcm7"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU365012"}],"value":"MCM7"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU365012"}],"value":"Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"ATP + H2O = ADP + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13065"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"3.6.4.12","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU365012"}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU365012"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU365012"}],"value":"Belongs to the MCM family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"MCM C-terminal AAA(+) ATPase","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50051"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97230.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97230.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023306"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022705"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0235","category":"Biological process","name":"DNA replication"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022806"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU365012"}],"id":"KW-0347","category":"Molecular function","name":"Helicase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU365012"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01410"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"33242583","citationType":"journal article","authors":["Garrido-Benavent I.","Perez-Ortega S.","de Los Rios A.","Mayrhofer H.","Fernandez-Mendoza F."],"citationCrossReferences":[{"database":"PubMed","id":"33242583"}],"title":"Neogene speciation and Pleistocene expansion of the genus Pseudephebe (Parmeliaceae, lichenized fungi) involving multiple colonizations of Antarctica.","publicationDate":"2020","journal":"Mol. Phylogenet. Evol.","firstPage":"0","lastPage":"0","volume":"107020"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97230.1"}],"value":"IGB802","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97230.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT416168","properties":[{"key":"ProteinId","value":"QQC97230.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7T4U5H1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0031261","properties":[{"key":"GoTerm","value":"C:DNA replication preinitiation complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0042555","properties":[{"key":"GoTerm","value":"C:MCM complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005656","properties":[{"key":"GoTerm","value":"C:nuclear pre-replicative complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0043596","properties":[{"key":"GoTerm","value":"C:nuclear replication fork"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003697","properties":[{"key":"GoTerm","value":"F:single-stranded DNA binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0017116","properties":[{"key":"GoTerm","value":"F:single-stranded DNA helicase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006270","properties":[{"key":"GoTerm","value":"P:DNA replication initiation"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006271","properties":[{"key":"GoTerm","value":"P:DNA strand elongation involved in DNA replication"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0000727","properties":[{"key":"GoTerm","value":"P:double-strand break repair via break-induced replication"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006279","properties":[{"key":"GoTerm","value":"P:premeiotic DNA replication"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"2.20.28.10:FF:000004","properties":[{"key":"EntryName","value":"DNA replication licensing factor MCM7"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.50.140","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR031327","properties":[{"key":"EntryName","value":"MCM"}]},{"database":"InterPro","id":"IPR008050","properties":[{"key":"EntryName","value":"MCM7"}]},{"database":"InterPro","id":"IPR001208","properties":[{"key":"EntryName","value":"MCM_dom"}]},{"database":"InterPro","id":"IPR033762","properties":[{"key":"EntryName","value":"MCM_OB"}]},{"database":"InterPro","id":"IPR012340","properties":[{"key":"EntryName","value":"NA-bd_OB-fold"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"PANTHER","id":"PTHR11630","properties":[{"key":"EntryName","value":"DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11630:SF26","properties":[{"key":"EntryName","value":"DNA REPLICATION LICENSING FACTOR MCM7"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00493","properties":[{"key":"EntryName","value":"MCM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17207","properties":[{"key":"EntryName","value":"MCM_OB"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01663","properties":[{"key":"EntryName","value":"MCMPROTEIN7"}]},{"database":"SMART","id":"SM00350","properties":[{"key":"EntryName","value":"MCM"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50249","properties":[{"key":"EntryName","value":"Nucleic acid-binding proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50051","properties":[{"key":"EntryName","value":"MCM_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"RCGCEIFQPVTSKQFTPMTECPSEECKQNNSKGQLFLSTRASKFLPFQEVKIQEMADQVPVGHIPRTLTVHCHGTLTRQINPGDVIDVAGIFLPTPYTGFKAIRAGLLTDTYLEAQHVNQHKKAYDDLVFDAKTFRRIEQYKHSGHMYEYLSRSIAPEIYGHQDVKKALLLLLIGGVTKEMGDGMRIRGDINI","length":193,"molWeight":21796,"crc64":"B2AE23A555889D47","md5":"8066A31C4ADBB373F52CA04B50EEB4F7"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI001936D662"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7T4PVZ5","uniProtkbId":"A0A7T4PVZ5_PSEFF","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-06-02","entryVersion":19,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97264.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013061"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000532"}],"value":"Phosphoglycerate kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013061"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000532"}],"value":"2.7.2.3"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97264.1"}],"value":"PGK"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:14801"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:57604"},{"database":"ChEBI","id":"CHEBI:58272"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.2.3","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000642"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000532"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004838"}],"value":"Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000696"}],"value":"Monomer"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000532"}],"value":"Belongs to the phosphoglycerate kinase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97264.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97264.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022840"}],"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023152"}],"id":"KW-0324","category":"Biological process","name":"Glycolysis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022777"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000532"}],"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000532"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"33242583","citationType":"journal article","authors":["Garrido-Benavent I.","Perez-Ortega S.","de Los Rios A.","Mayrhofer H.","Fernandez-Mendoza F."],"citationCrossReferences":[{"database":"PubMed","id":"33242583"}],"title":"Neogene speciation and Pleistocene expansion of the genus Pseudephebe (Parmeliaceae, lichenized fungi) involving multiple colonizations of Antarctica.","publicationDate":"2020","journal":"Mol. Phylogenet. Evol.","firstPage":"0","lastPage":"0","volume":"107020"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97264.1"}],"value":"IGB802","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97264.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT416202","properties":[{"key":"ProteinId","value":"QQC97264.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0043531","properties":[{"key":"GoTerm","value":"F:ADP binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0004618","properties":[{"key":"GoTerm","value":"F:phosphoglycerate kinase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006094","properties":[{"key":"GoTerm","value":"P:gluconeogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006096","properties":[{"key":"GoTerm","value":"P:glycolytic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.1260","properties":[{"key":"EntryName","value":"Phosphoglycerate kinase, N-terminal domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001576","properties":[{"key":"EntryName","value":"Phosphoglycerate_kinase"}]},{"database":"InterPro","id":"IPR015824","properties":[{"key":"EntryName","value":"Phosphoglycerate_kinase_N"}]},{"database":"InterPro","id":"IPR036043","properties":[{"key":"EntryName","value":"Phosphoglycerate_kinase_sf"}]},{"database":"PANTHER","id":"PTHR11406","properties":[{"key":"EntryName","value":"PHOSPHOGLYCERATE KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11406:SF0","properties":[{"key":"EntryName","value":"PHOSPHOGLYCERATE KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00162","properties":[{"key":"EntryName","value":"PGK"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00477","properties":[{"key":"EntryName","value":"PHGLYCKINASE"}]},{"database":"SUPFAM","id":"SSF53748","properties":[{"key":"EntryName","value":"Phosphoglycerate kinase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"ILMSHLGRPEGHPNPKYSLKPVVPELEKLLGKKVIFTEDCVGKEVEETVNKASDGEVVLLENLRFHAEEEGSSKDSEGKKVKADKGDVDXFRKGLTALGDVYINDAFGTAHRAHSSMVGVKLPEKASGFLMKKELDYFAQALEKPKRPFLAILGGAKVSDKIQLIDNLLSKVDSLIICGGMAFTFKKTLENVKIGNSL","length":198,"molWeight":21650,"crc64":"713EBF54B58D35E7","md5":"A35660968078100691BD50E7FE6C0F7A"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":1,"SUBUNIT":1,"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI00193782B2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A1BY02","uniProtkbId":"A1BY02_PSEFF","entryAudit":{"firstPublicDate":"2007-01-23","lastAnnotationUpdateDate":"2025-10-08","lastSequenceUpdateDate":"2007-01-23","entryVersion":46,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL07120.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"DNA-directed RNA polymerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"2.7.7.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL07120.1"}],"value":"RPB1"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"RNA polymerase Rpb1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04997"}]},{"type":"Region","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL07120.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL07120.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022478"}],"id":"KW-0240","category":"Cellular component","name":"DNA-directed RNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-AL2HL5KK8EA8C","citationType":"submission","authors":["Lumbsch T.","Schmitt I.","Luecking R.","Wiklund E.","Wedin M."],"publicationDate":"JUL-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL07120.1"}]},{"referenceNumber":2,"citation":{"id":"17363237","citationType":"journal article","authors":["Lumbsch H.T.","Schmitt I.","Lucking R.","Wiklund E.","Wedin M."],"citationCrossReferences":[{"database":"PubMed","id":"17363237"},{"database":"DOI","id":"10.1016/j.mycres.2007.01.006"}],"title":"The phylogenetic placement of Ostropales within Lecanoromycetes (Ascomycota) revisited.","publicationDate":"2007","journal":"Mycol. Res.","firstPage":"257","lastPage":"267","volume":"111"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABL07120.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ870990","properties":[{"key":"ProteinId","value":"ABL07120.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A1BY02","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005665","properties":[{"key":"GoTerm","value":"C:RNA polymerase II, core complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003899","properties":[{"key":"GoTerm","value":"F:DNA-directed RNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR045867","properties":[{"key":"EntryName","value":"DNA-dir_RpoC_beta_prime"}]},{"database":"InterPro","id":"IPR007080","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_1"}]},{"database":"PANTHER","id":"PTHR19376","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19376:SF37","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04997","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64484","properties":[{"key":"EntryName","value":"beta and beta-prime subunits of DNA dependent RNA-polymerase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"FMTKIKKLLETVCHNCGKILVDESNPAFADAIRRRDPKKRFDSVWRLCKPKMICETTMALDEDAPSDKTKEPKHDHGGCGNIQPEVRREGLRLTGTWKAQKGDEENEGQQPEKKPITPQMALNIFRHISTDDIKRMGLSNDYARPEWMIITVLPVPPPPVRPSISVDGGNGPRGEDDLTYKLGDIIRANGNVRRCETEGSPA","length":202,"molWeight":22686,"crc64":"8F7021EA2328AC04","md5":"9241C6F5EBD5049F7F12B33CE7A3CF33"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI0000EA2CA2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7KAJ4","uniProtkbId":"A7KAJ4_PSEFF","entryAudit":{"firstPublicDate":"2007-09-11","lastAnnotationUpdateDate":"2025-10-08","lastSequenceUpdateDate":"2007-09-11","entryVersion":44,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS82489.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"DNA-directed RNA polymerase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012418"}],"value":"2.7.7.6"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS82489.1"}],"value":"RPB1"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"RNA polymerase Rpb1","evidences":[{"evidenceCode":"ECO:0000259","source":"Pfam","id":"PF04997"}]},{"type":"Region","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS82489.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS82489.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022478"}],"id":"KW-0240","category":"Cellular component","name":"DNA-directed RNA polymerase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022695"}],"id":"KW-0548","category":"Molecular function","name":"Nucleotidyltransferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023163"}],"id":"KW-0804","category":"Biological process","name":"Transcription"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"17276700","citationType":"journal article","authors":["Crespo A.","Lumbsch H.T.","Mattsson J.E.","Blanco O.","Divakar P.K.","Articus K.","Wiklund E.","Bawingan P.A.","Wedin M."],"citationCrossReferences":[{"database":"PubMed","id":"17276700"},{"database":"DOI","id":"10.1016/j.ympev.2006.11.029"}],"title":"Testing morphology-based hypotheses of phylogenetic relationships in Parmeliaceae (Ascomycota) using three ribosomal markers and the nuclear RPB1 gene.","publicationDate":"2007","journal":"Mol. Phylogenet. Evol.","firstPage":"812","lastPage":"824","volume":"44"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABS82489.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF105435","properties":[{"key":"ProteinId","value":"ABS82489.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7KAJ4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005665","properties":[{"key":"GoTerm","value":"C:RNA polymerase II, core complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003899","properties":[{"key":"GoTerm","value":"F:DNA-directed RNA polymerase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0006351","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR045867","properties":[{"key":"EntryName","value":"DNA-dir_RpoC_beta_prime"}]},{"database":"InterPro","id":"IPR007080","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_1"}]},{"database":"PANTHER","id":"PTHR19376","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19376:SF37","properties":[{"key":"EntryName","value":"DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04997","properties":[{"key":"EntryName","value":"RNA_pol_Rpb1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64484","properties":[{"key":"EntryName","value":"beta and beta-prime subunits of DNA dependent RNA-polymerase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VYHVGFMTKIKKLLETVCHNCGKILVDESNPAFADAIRRRDPKKRFDSVWRLCKPKMICETTMALDEDAPSDKTKEPKHDHGGCGNIQPEVRREGLRLTGTWKAQKGDEENEGQQPEKKPITPQMALNIFRHISTDDIKRMGLSNDYARPEWMIITVLPVPPPPVRPSISVDGGNGPRGEDDLTYKLGDIIRANGNVRRCETEGSPAHVVNELSSCC","length":217,"molWeight":24314,"crc64":"00BCECBAC44179C3","md5":"3A941224CA91F24E318E46F92E63552F"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Region":2,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI00015A1DFB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0L3G4","uniProtkbId":"B0L3G4_PSEFF","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":52,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABQ08174.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}],"value":"Beta-ketoacyl-acyl-carrier-protein synthase I"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}],"value":"2.3.1.41"}]},"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22836"},{"database":"Rhea","id":"RHEA-COMP:9623"},{"database":"Rhea","id":"RHEA-COMP:9685"},{"database":"Rhea","id":"RHEA-COMP:9916"},{"database":"Rhea","id":"RHEA-COMP:14125"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:64479"},{"database":"ChEBI","id":"CHEBI:78449"},{"database":"ChEBI","id":"CHEBI:78776"},{"database":"ChEBI","id":"CHEBI:138651"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}]}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"Ketosynthase family 3 (KS3)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS52004"}]},{"type":"Active site","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABQ08174.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABQ08174.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022450"}],"id":"KW-0596","category":"PTM","name":"Phosphopantetheine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"18280127","citationType":"journal article","authors":["Muggia L.","Schmitt I.","Grube M."],"citationCrossReferences":[{"database":"PubMed","id":"18280127"},{"database":"DOI","id":"10.1016/j.mycres.2007.08.020"}],"title":"Purifying selection is a prevailing motif in the evolution of ketoacyl synthase domains of polyketide synthases from lichenized fungi.","publicationDate":"2008","journal":"Mycol. Res.","firstPage":"277","lastPage":"288","volume":"112"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABQ08174.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF212824","properties":[{"key":"ProteinId","value":"ABQ08174.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0L3G4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004315","properties":[{"key":"GoTerm","value":"F:3-oxoacyl-[acyl-carrier-protein] synthase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004312","properties":[{"key":"GoTerm","value":"F:fatty acid synthase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006633","properties":[{"key":"GoTerm","value":"P:fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0044550","properties":[{"key":"GoTerm","value":"P:secondary metabolite biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00833","properties":[{"key":"EntryName","value":"PKS"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.47.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR014030","properties":[{"key":"EntryName","value":"KAS_N"}]},{"database":"InterPro","id":"IPR018201","properties":[{"key":"EntryName","value":"Ketoacyl_synth_AS"}]},{"database":"InterPro","id":"IPR020841","properties":[{"key":"EntryName","value":"PKS_Beta-ketoAc_synthase_dom"}]},{"database":"InterPro","id":"IPR050091","properties":[{"key":"EntryName","value":"PKS_NRPS_Biosynth_Enz"}]},{"database":"InterPro","id":"IPR016039","properties":[{"key":"EntryName","value":"Thiolase-like"}]},{"database":"PANTHER","id":"PTHR43775","properties":[{"key":"EntryName","value":"FATTY ACID SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43775:SF37","properties":[{"key":"EntryName","value":"SI:DKEY-61P9.11"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00109","properties":[{"key":"EntryName","value":"ketoacyl-synt"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00825","properties":[{"key":"EntryName","value":"PKS_KS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53901","properties":[{"key":"EntryName","value":"Thiolase-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00606","properties":[{"key":"EntryName","value":"KS3_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52004","properties":[{"key":"EntryName","value":"KS3_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SPREAYQTDPMGRLALVTAYEALEMSGFMPNRTPSSMLDRVGTFYGQTSDDWRQVNAAQNIDTYYIPGTIRAFASGRINYNFKFKGPSYNVDTACSSSFAAIQLACTSLQAKECDTAVAGGLNVMTTPDLFAGLSRAQFLSKTGSCKTFDDTADGFCRGDGVATVILKRLEDAEIDNDPILGVILGTATNHSSEAVSITQPHAPAQESLYRKILSNARVDARDI","length":224,"molWeight":24205,"crc64":"8E4355C38A79316D","md5":"70DC2EACE679BA9C891C2439EC0C52D4"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1},"countByFeatureType":{"Domain":1,"Active site":1,"Non-terminal residue":2},"uniParcId":"UPI00016411D6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0L3G5","uniProtkbId":"B0L3G5_PSEFF","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":51,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABQ08175.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}],"value":"Beta-ketoacyl-acyl-carrier-protein synthase I"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}],"value":"2.3.1.41"}]},"flag":"Fragment"},"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:22836"},{"database":"Rhea","id":"RHEA-COMP:9623"},{"database":"Rhea","id":"RHEA-COMP:9685"},{"database":"Rhea","id":"RHEA-COMP:9916"},{"database":"Rhea","id":"RHEA-COMP:14125"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:64479"},{"database":"ChEBI","id":"CHEBI:78449"},{"database":"ChEBI","id":"CHEBI:78776"},{"database":"ChEBI","id":"CHEBI:138651"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}]}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"Ketosynthase family 3 (KS3)","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS52004"}]},{"type":"Active site","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10022"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABQ08175.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABQ08175.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022450"}],"id":"KW-0596","category":"PTM","name":"Phosphopantetheine"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"18280127","citationType":"journal article","authors":["Muggia L.","Schmitt I.","Grube M."],"citationCrossReferences":[{"database":"PubMed","id":"18280127"},{"database":"DOI","id":"10.1016/j.mycres.2007.08.020"}],"title":"Purifying selection is a prevailing motif in the evolution of ketoacyl synthase domains of polyketide synthases from lichenized fungi.","publicationDate":"2008","journal":"Mycol. Res.","firstPage":"277","lastPage":"288","volume":"112"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABQ08175.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EF212825","properties":[{"key":"ProteinId","value":"ABQ08175.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0L3G5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0004315","properties":[{"key":"GoTerm","value":"F:3-oxoacyl-[acyl-carrier-protein] synthase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004312","properties":[{"key":"GoTerm","value":"F:fatty acid synthase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006633","properties":[{"key":"GoTerm","value":"P:fatty acid biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0044550","properties":[{"key":"GoTerm","value":"P:secondary metabolite biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00833","properties":[{"key":"EntryName","value":"PKS"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.47.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR014030","properties":[{"key":"EntryName","value":"KAS_N"}]},{"database":"InterPro","id":"IPR018201","properties":[{"key":"EntryName","value":"Ketoacyl_synth_AS"}]},{"database":"InterPro","id":"IPR020841","properties":[{"key":"EntryName","value":"PKS_Beta-ketoAc_synthase_dom"}]},{"database":"InterPro","id":"IPR050091","properties":[{"key":"EntryName","value":"PKS_NRPS_Biosynth_Enz"}]},{"database":"InterPro","id":"IPR016039","properties":[{"key":"EntryName","value":"Thiolase-like"}]},{"database":"PANTHER","id":"PTHR43775","properties":[{"key":"EntryName","value":"FATTY ACID SYNTHASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43775:SF37","properties":[{"key":"EntryName","value":"SI:DKEY-61P9.11"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00109","properties":[{"key":"EntryName","value":"ketoacyl-synt"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00825","properties":[{"key":"EntryName","value":"PKS_KS"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53901","properties":[{"key":"EntryName","value":"Thiolase-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00606","properties":[{"key":"EntryName","value":"KS3_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52004","properties":[{"key":"EntryName","value":"KS3_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SPREATQTDPMHRLGLASAYEALEMAGYVPNRSPSTRLERIGTFYGQTSDDWREINEAQDIDTYFITAGVRAFAPGRINYYFKFSGPSFSVDTACSSSAAAMQLACTSLWAGDCDTAVAGGLNVMTNSDIFAGLSRGQFLSKTGNCQTFDNDADGYCRGDGIGTVILKRLDDALADNDRILGVILETATNHSANAISITHPHAPTQEVLFKKVMDDAGKDPHDV","length":224,"molWeight":24146,"crc64":"9F1FFF047D0CAEC6","md5":"83029E06715C2E43CC085C2BD910101C"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1},"countByFeatureType":{"Domain":1,"Active site":1,"Non-terminal residue":2},"uniParcId":"UPI00016411D7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7T4PVZ0","uniProtkbId":"A0A7T4PVZ0_PSEFF","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-06-02","entryVersion":14,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97240.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97240.1"}],"value":"Translation elongation factor 1 alpha"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97240.1"}],"value":"TEF1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}],"value":"Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01059"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Tr-type G","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51722"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97240.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97240.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97240.1"}],"id":"KW-0251","category":"Molecular function","name":"Elongation factor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023134"}],"id":"KW-0342","category":"Ligand","name":"GTP-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022741"}],"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97240.1"}],"id":"KW-0648","category":"Biological process","name":"Protein biosynthesis"}],"references":[{"referenceNumber":1,"citation":{"id":"33242583","citationType":"journal article","authors":["Garrido-Benavent I.","Perez-Ortega S.","de Los Rios A.","Mayrhofer H.","Fernandez-Mendoza F."],"citationCrossReferences":[{"database":"PubMed","id":"33242583"}],"title":"Neogene speciation and Pleistocene expansion of the genus Pseudephebe (Parmeliaceae, lichenized fungi) involving multiple colonizations of Antarctica.","publicationDate":"2020","journal":"Mol. Phylogenet. Evol.","firstPage":"0","lastPage":"0","volume":"107020"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97240.1"}],"value":"IGB802","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97240.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT416178","properties":[{"key":"ProteinId","value":"QQC97240.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7T4PVZ0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005525","properties":[{"key":"GoTerm","value":"F:GTP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003924","properties":[{"key":"GoTerm","value":"F:GTPase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.40.30.10","properties":[{"key":"EntryName","value":"Translation factors"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR000795","properties":[{"key":"EntryName","value":"T_Tr_GTP-bd_dom"}]},{"database":"InterPro","id":"IPR050100","properties":[{"key":"EntryName","value":"TRAFAC_GTPase_members"}]},{"database":"PANTHER","id":"PTHR23115","properties":[{"key":"EntryName","value":"TRANSLATION FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00009","properties":[{"key":"EntryName","value":"GTP_EFTU"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00315","properties":[{"key":"EntryName","value":"ELONGATNFCT"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51722","properties":[{"key":"EntryName","value":"G_TR_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"KNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAFTLGVRQLIVAINKMDTAKWSGDRYNEIIKETSNFIKKVGYNPKTVPFVPISGFNGDNMIDESPNCPWYKGWEKETKTKTTGKTLLEAIDAIDPPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVTFAPANVTTEVKSVEMH","length":193,"molWeight":20952,"crc64":"3C3B92FD66E800A0","md5":"BB09700169614F5F843186B083A874E9"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI001937945D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A7T4U5A9","uniProtkbId":"A0A7T4U5A9_PSEFF","entryAudit":{"firstPublicDate":"2021-06-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-06-02","entryVersion":16,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Pseudevernia furfuracea","commonName":"Tree moss","taxonId":136282,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97257.1"}],"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Lecanoromycetes","OSLEUM clade","Lecanoromycetidae","Lecanorales","Lecanorineae","Parmeliaceae","Pseudevernia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000659"}],"value":"Ribosomal protein"}},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97257.1"}],"value":"L1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00010531"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000659"}],"value":"Belongs to the universal ribosomal protein uL1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97257.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97257.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023274"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000659"}],"id":"KW-0687","category":"Molecular function","name":"Ribonucleoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022980"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000659"}],"id":"KW-0689","category":"Molecular function","name":"Ribosomal protein"}],"references":[{"referenceNumber":1,"citation":{"id":"33242583","citationType":"journal article","authors":["Garrido-Benavent I.","Perez-Ortega S.","de Los Rios A.","Mayrhofer H.","Fernandez-Mendoza F."],"citationCrossReferences":[{"database":"PubMed","id":"33242583"}],"title":"Neogene speciation and Pleistocene expansion of the genus Pseudephebe (Parmeliaceae, lichenized fungi) involving multiple colonizations of Antarctica.","publicationDate":"2020","journal":"Mol. Phylogenet. Evol.","firstPage":"0","lastPage":"0","volume":"107020"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97257.1"}],"value":"IGB802","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"QQC97257.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"MT416195","properties":[{"key":"ProteinId","value":"QQC97257.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A7T4U5A9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00403","properties":[{"key":"EntryName","value":"Ribosomal_L1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.790:FF:000002","properties":[{"key":"EntryName","value":"Ribosomal protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.790","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050257","properties":[{"key":"EntryName","value":"eL8/uL1-like"}]},{"database":"InterPro","id":"IPR023674","properties":[{"key":"EntryName","value":"Ribosomal_uL1-like"}]},{"database":"InterPro","id":"IPR028364","properties":[{"key":"EntryName","value":"Ribosomal_uL1/biogenesis"}]},{"database":"InterPro","id":"IPR016095","properties":[{"key":"EntryName","value":"Ribosomal_uL1_3-a/b-sand"}]},{"database":"InterPro","id":"IPR023673","properties":[{"key":"EntryName","value":"Ribosomal_uL1_CS"}]},{"database":"PANTHER","id":"PTHR23105","properties":[{"key":"EntryName","value":"RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00687","properties":[{"key":"EntryName","value":"Ribosomal_L1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56808","properties":[{"key":"EntryName","value":"Ribosomal protein L1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01199","properties":[{"key":"EntryName","value":"RIBOSOMAL_L1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DKRFSGTIKLPTVPRPNMSICVLGDQHDIDRAKHHGVDAMSSDDLKKLNKNKKLIKKLARKYDSFISSDTLIKQIPRLLGPGLSKAGKFPTPISHNED","length":98,"molWeight":10934,"crc64":"FFAD4FDFC00B8E12","md5":"4E8D77C30DF22F83EEC9281CFEB43DC7"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Non-terminal residue":2},"uniParcId":"UPI001934B978"}}]}