{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXX1","uniProtkbId":"TXU8F_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2025-02-05","entryVersion":6,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(8)-Mo15"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(8)-Mo15"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70383.1"}],"value":"U-MPTX.8-15"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"Aerolysin-like pore-forming toxin"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"Megalysin"}}],"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"May function as a large pore-forming protein"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"Target cell membrane","id":"SL-0451"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"Contains 3 disulfide bonds"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":31526.9,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the megalysin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"U-megalopygitoxin(8)-Mo15","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461529"}],"keywords":[{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-1052","category":"Cellular component","name":"Target cell membrane"},{"id":"KW-1053","category":"Cellular component","name":"Target membrane"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","3D-STRUCTURE MODELING","RECOMBINANT EXPRESSION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514865","properties":[{"key":"ProteinId","value":"WJJ70383.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXX1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"database":"CDD","id":"cd20235","properties":[{"key":"EntryName","value":"PFM_spherulin-2a-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.170.15.10","properties":[{"key":"EntryName","value":"Proaerolysin, chain A, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR053237","properties":[{"key":"EntryName","value":"Natterin-like_C"}]},{"database":"PANTHER","id":"PTHR39244:SF5","properties":[{"key":"EntryName","value":"NATTERIN-3-LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39244","properties":[{"key":"EntryName","value":"NATTERIN-4"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56973","properties":[{"key":"EntryName","value":"Aerolisin/ETX pore-forming domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARFSSKNLTKLFQYLVLSLLSPVAFGNFNIEVDTRNKVLNDAAINFYGQNIGIITDGERRVFGITDGPLKEACSKVQGGKPGYVWVRSPTPANLYEIHNWRQVLRVLTAYDARIVGIEQKPEMVATQTYKNRSDHPAKVSGMITQSVSNTIENKWIEMNQFSITATVSCKVKAAEIGLSMGYERSWGKEDTNSTTTMLGQQTGFEVELPPGGNCTAVLSATKGSMKIDVGYRATLEGDCAVDFPNTWNGHHYWCYPIGLVQDVGNLKKHIDCRELITIGYYSDAHVTIENLGKKKNKKTKKPPRKTKMN","length":310,"molWeight":34567,"crc64":"827825C5A50C485C","md5":"930B991AEB9FA1DC5834852CFE4DF995"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI00388C33C7"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXX2","uniProtkbId":"TXU8C_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2025-02-05","entryVersion":5,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(8)-Mo12"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(8)-Mo12"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70381.1"}],"value":"U-MPTX.8-12"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"Aerolysin-like pore-forming toxin"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"Megalysin"}}],"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"May function as a large pore-forming protein"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"Target cell membrane","id":"SL-0451"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"Contains 2 disulfide bonds"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":29818.77,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the megalysin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"U-megalopygitoxin(8)-Mo12","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461530"},{"type":"Modified residue","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Histidine amide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]}],"keywords":[{"id":"KW-0027","category":"PTM","name":"Amidation"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-1052","category":"Cellular component","name":"Target cell membrane"},{"id":"KW-1053","category":"Cellular component","name":"Target membrane"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","PROBABLE AMIDATION AT HIS-284","3D-STRUCTURE MODELING","RECOMBINANT EXPRESSION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514863","properties":[{"key":"ProteinId","value":"WJJ70381.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXX2","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"database":"CDD","id":"cd20235","properties":[{"key":"EntryName","value":"PFM_spherulin-2a-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.170.15.10","properties":[{"key":"EntryName","value":"Proaerolysin, chain A, domain 3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56973","properties":[{"key":"EntryName","value":"Aerolisin/ETX pore-forming domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNLQYLILSLLSTTVYGGFNLNFDSKGDALEKAAIDFTGEDVAVIKENERESFGITDGPLKDACGKVSGRRPDHVWLYKPTLWGDMYTMYKWPEVTRTLTPIAARVVGKEQKPMIVSSQVYRNRSNRTVKVNGKISQEVTNTVENKWSKTHGLSVTASMTYSFKVVEASMEIGYTSEWGQEETKSESVAVGQEMGFESELQPGESVEAVLSATKGSMIIDVTYRATLDGCCAINYNNGWKGHHYYCYPIGMVQDAGKLKKHVDVKETIKIGFYSDSHVIVRDKHGKK","length":287,"molWeight":32066,"crc64":"70960EDBEB50110C","md5":"6C6713A821F72A67C9864AF8A7BE55DB"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Modified residue":1},"uniParcId":"UPI00388C33AD"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXW7","uniProtkbId":"TXU29_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2025-02-05","entryVersion":4,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(2)-Mo9"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(2)-Mo9"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70365.1"}],"value":"U-MPTX.2-9"}]},"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable toxin"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"Contains 2 disulfide bonds"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":3328.55,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the caterpillar 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Peptide","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"U-megalopygitoxin(2)-Mo9","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461525"},{"type":"Modified residue","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Pyrrolidone carboxylic acid","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"type":"Modified residue","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Threonine amide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]}],"keywords":[{"id":"KW-0027","category":"PTM","name":"Amidation"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0873","category":"PTM","name":"Pyrrolidone carboxylic acid"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","SYNTHESIS OF 26-55","PYROGLUTAMATE FORMATION AT GLN-26","AMIDATION AT THR-55","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514847","properties":[{"key":"ProteinId","value":"WJJ70365.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXW7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]}],"sequence":{"value":"MKFIVLLLIVTSVLMMFAVTTEASPQVNHKIERAKCGQKGKCYDGVNVQCIDCNTG","length":56,"molWeight":6147,"crc64":"79648B15B922AFB1","md5":"631EF3AA588C12A8E2E303D7BEFB02BF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Peptide":1,"Modified residue":2},"uniParcId":"UPI00388C33BA"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXW3","uniProtkbId":"TXU11_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2025-02-05","entryVersion":6,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(1)-Mo1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(1)-Mo1"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70362.1"}],"value":"U-MPTX.1-1"}]},"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable toxin"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"Contains 4 disulfide bonds"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":9188.36,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the caterpillar 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"U-megalopygitoxin(1)-Mo1","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461521"}],"keywords":[{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","RECOMBINANT EXPRESSION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514844","properties":[{"key":"ProteinId","value":"WJJ70362.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXW3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DXW3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"database":"InterPro","id":"IPR029277","properties":[{"key":"EntryName","value":"SVWC_dom"}]},{"database":"InterPro","id":"IPR053308","properties":[{"key":"EntryName","value":"Vago-like"}]},{"database":"PANTHER","id":"PTHR39957","properties":[{"key":"EntryName","value":"AT09846P1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39957:SF1","properties":[{"key":"EntryName","value":"AT09846P1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15430","properties":[{"key":"EntryName","value":"SVWC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MYRETFVFCVLLAVVSANVEMRDLEEKPEKYKGVNCCYVSAIQECIPVGETRPFKHECKGWTCNKDNLLEVSCGKVLVEHYVEDKTAPYPHCCPVAKA","length":98,"molWeight":11133,"crc64":"8C870F89D10C4EAB","md5":"F1FA4A36B245D6B37A0C6588969F365B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI00388C33B0"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXW6","uniProtkbId":"TXU45_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2025-02-05","entryVersion":4,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(4)-Mo5"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(4)-Mo5"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70368.1"}],"value":"U-MPTX.4-5"}]},"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable toxin"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":1944.05,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the caterpillar 4 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Peptide","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"U-megalopygitoxin(4)-Mo5","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461524"}],"keywords":[{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","SYNTHESIS OF 24-40","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514850","properties":[{"key":"ProteinId","value":"WJJ70368.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXW6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]}],"sequence":{"value":"MKCSLLLVVFAAMVALFAAGTNAAMNQRKMLEVIGGLKKEK","length":41,"molWeight":4397,"crc64":"C15244D20BA9B068","md5":"A86449A777F7F07ACB84B7B3F30F012A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Peptide":1},"uniParcId":"UPI00388C33C9"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXX0","uniProtkbId":"TXU33_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2025-02-05","entryVersion":5,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(3)-Mo3"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(3)-Mo3"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70366.1"}],"value":"U-MPTX.3-3"}]},"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable toxin"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"Contains 3 disulfide bonds"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":7202.15,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the caterpillar 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"U-megalopygitoxin(3)-Mo3","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461528"}],"keywords":[{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514848","properties":[{"key":"ProteinId","value":"WJJ70366.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXX0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DXX0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"database":"CDD","id":"cd00104","properties":[{"key":"EntryName","value":"KAZAL_FS"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.60.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002350","properties":[{"key":"EntryName","value":"Kazal_dom"}]},{"database":"InterPro","id":"IPR036058","properties":[{"key":"EntryName","value":"Kazal_dom_sf"}]},{"database":"SUPFAM","id":"SSF100895","properties":[{"key":"EntryName","value":"Kazal-type serine protease inhibitors"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MYSKYVIIISLLAVVSLGSAIEFWNPEECGCPPFDKTENEVCTKHGTTYDNRCQFDCHQKFLSKSGVALEEGPCILSAEAEEEAKK","length":86,"molWeight":9579,"crc64":"51BBCCDAB617A7C9","md5":"2CE297FA9E479D400C5317C9C8D10BF3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI00388C3391"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXW5","uniProtkbId":"TXU34_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2025-02-05","entryVersion":5,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(3)-Mo4"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(3)-Mo4"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70367.1"}],"value":"U-MPTX.3-4"}]},"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable toxin"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"Contains 3 disulfide bonds"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":6872.12,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the caterpillar 3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"U-megalopygitoxin(3)-Mo4","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461523"}],"keywords":[{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","RECOMBINANT EXPRESSION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514849","properties":[{"key":"ProteinId","value":"WJJ70367.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXW5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DXW5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"database":"CDD","id":"cd00104","properties":[{"key":"EntryName","value":"KAZAL_FS"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.60.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002350","properties":[{"key":"EntryName","value":"Kazal_dom"}]},{"database":"InterPro","id":"IPR036058","properties":[{"key":"EntryName","value":"Kazal_dom_sf"}]},{"database":"Pfam","id":"PF07648","properties":[{"key":"EntryName","value":"Kazal_2"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF100895","properties":[{"key":"EntryName","value":"Kazal-type serine protease inhibitors"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNSKFVLIVVFLAVVSICFANEVWDPEKCGCPPFDKVENAVCTKDRATYDNRCQFDCHAKFLSKSGKTLEESPCIESADPK","length":81,"molWeight":9065,"crc64":"448FFF963FB02F44","md5":"20549CC139F4DB8886A4095E5AD5F7BD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI00388C338D"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXW8","uniProtkbId":"TXU9D_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2025-02-05","entryVersion":4,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(9)-Mo13"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(9)-Mo13"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70391.1"}],"value":"U-MPTX.9-13"}]},"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable toxin"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":3018.43,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the caterpillar 9 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Peptide","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"U-megalopygitoxin(9)-Mo13","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461526"},{"type":"Disulfide bond","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}]}],"keywords":[{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","SYNTHESIS OF 24-48","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514873","properties":[{"key":"ProteinId","value":"WJJ70391.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXW8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P0DXW8","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]}],"sequence":{"value":"MKLVFLFFIVAVMVSLFVGMTEADKPRFLTTVCQDTYEKCKEQMLKKDKK","length":50,"molWeight":5880,"crc64":"5563084FEF1809AB","md5":"4CB8BEC3D91F58A66F9B8F20FA354197"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Peptide":1,"Disulfide bond":1},"uniParcId":"UPI00388C33A0"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXW4","uniProtkbId":"TXU22_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2025-02-05","entryVersion":4,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(2)-Mo2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(2)-Mo2"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70364.1"}],"value":"U-MPTX.2-2"}]},"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable toxin"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"value":"Contains 2 disulfide bonds"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":2717.26,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the caterpillar 2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Peptide","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"U-megalopygitoxin(2)-Mo2","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461522"}],"keywords":[{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","SYNTHESIS OF 30-55","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514846","properties":[{"key":"ProteinId","value":"WJJ70364.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXW4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]}],"sequence":{"value":"MKFVVLLMIVAAAVAMFAAGTEAFPEPIPASNNFLRKRCAGQGKCIGNGECVPCP","length":55,"molWeight":5741,"crc64":"1C0FB2BAC7245C5D","md5":"5EAA686B2303F25E241B61206CE600D0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Peptide":1},"uniParcId":"UPI00388C339E"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P0DXW9","uniProtkbId":"TXUB_MEGOP","entryAudit":{"firstPublicDate":"2025-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2025-02-05","entryVersion":4,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Megalopyge opercularis","commonName":"Southern flannel moth","synonyms":["Phalaena opercularis"],"taxonId":1113279,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Lepidoptera","Glossata","Ditrysia","Zygaenoidea","Megalopygidae","Megalopyge"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-megalopygitoxin(11)-Mo28"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37428925"}],"value":"U-MPTX(11)-Mo28"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"WJJ70395.1"}],"value":"U-MPTX.11-28"}]},"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Probable toxin"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Expressed by the venom apparatus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}],"value":"Larvae"}],"commentType":"DEVELOPMENTAL STAGE"},{"commentType":"MASS SPECTROMETRY","method":"MALDI","molWeight":1201.68,"molWeightError":0.0,"note":"Monoisotopic mass.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the caterpillar 11 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Peptide","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"U-megalopygitoxin(11)-Mo28","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37428925"}],"featureId":"PRO_0000461527"}],"keywords":[{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0800","category":"Molecular function","name":"Toxin"}],"references":[{"referenceNumber":1,"citation":{"id":"37428925","citationType":"journal article","authors":["Walker A.A.","Robinson S.D.","Merritt D.J.","Cardoso F.C.","Goudarzi M.H.","Mercedes R.S.","Eagles D.A.","Cooper P.","Zdenek C.N.","Fry B.G.","Hall D.W.","Vetter I.","King G.F."],"citationCrossReferences":[{"database":"PubMed","id":"37428925"},{"database":"DOI","id":"10.1073/pnas.2305871120"}],"title":"Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).","publicationDate":"2023","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"e2305871120","lastPage":"e2305871120","volume":"120"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","MASS SPECTROMETRY","SYNTHESIS OF 30-40","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Venom","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"OP514877","properties":[{"key":"ProteinId","value":"WJJ70395.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"P0DXW9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37428925"}]}],"sequence":{"value":"MRTTLLLLIIAITVMVFVSEAYAAPAPEPILKQGTIESLTR","length":41,"molWeight":4472,"crc64":"6FE3226816FB5D34","md5":"82F0A0C1E276A546474336AA49551C2E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"MASS SPECTROMETRY":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Peptide":1},"uniParcId":"UPI00388C33C6"}}]}