{"results":[{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1L2","uniProtkbId":"B0I1L2_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-03-18","entryVersion":79,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99782.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021277"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"V(D)J recombination-activating protein 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012483"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"2.3.2.27"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"3.1.-.-"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99782.1"}],"value":"RAG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000900"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+)."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Belongs to the RAG1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50089"}]},{"type":"Domain","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"RAG1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51765"}]},{"type":"Domain","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"NBD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51487"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99782.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99782.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022759"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022722"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01101"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99782.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277336","properties":[{"key":"ProteinId","value":"BAF99782.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"GO","id":"GO:0097519","properties":[{"key":"GoTerm","value":"C:DNA recombinase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1905347","properties":[{"key":"GoTerm","value":"C:endodeoxyribonuclease complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:1990238","properties":[{"key":"GoTerm","value":"F:double-stranded DNA endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042393","properties":[{"key":"GoTerm","value":"F:histone binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030183","properties":[{"key":"GoTerm","value":"P:B cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0033077","properties":[{"key":"GoTerm","value":"P:T cell differentiation in thymus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0033151","properties":[{"key":"GoTerm","value":"P:V(D)J recombination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd16530","properties":[{"key":"EntryName","value":"RING-HC_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000142","properties":[{"key":"EntryName","value":"Recombination activating gene 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.140.510","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024627","properties":[{"key":"EntryName","value":"RAG1"}]},{"database":"InterPro","id":"IPR035714","properties":[{"key":"EntryName","value":"RAG1_imp-bd"}]},{"database":"InterPro","id":"IPR019485","properties":[{"key":"EntryName","value":"RAG1_Znf"}]},{"database":"InterPro","id":"IPR023336","properties":[{"key":"EntryName","value":"RAG_nonamer-bd_dom"}]},{"database":"InterPro","id":"IPR058558","properties":[{"key":"EntryName","value":"RING-HC_RAG1"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR018957","properties":[{"key":"EntryName","value":"Znf_C3HC4_RING-type"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR11539:SF0","properties":[{"key":"EntryName","value":"V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11539","properties":[{"key":"EntryName","value":"VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12940","properties":[{"key":"EntryName","value":"RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12560","properties":[{"key":"EntryName","value":"RAG1_imp_bd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00097","properties":[{"key":"EntryName","value":"zf-C3HC4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10426","properties":[{"key":"EntryName","value":"zf-RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51487","properties":[{"key":"EntryName","value":"NBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51765","properties":[{"key":"EntryName","value":"ZF_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SPYFNFSSDDLNLTTSSQSHSECMSQEENMVDNEDXDSSLKRIEEETHTSILQHLCRICGVSFKMDQQNRNYPVHGPVDDETQEVLRRREKKATSWPELISKVFKVDVRGDMDTIHPTRFCHNCWTIMHQKFSNTSSEVYFPRNKVVEWKSHSXTCDVCNNSKTWGKRKGGLIQSSLLPKKRKISIEHGKKNKNGNTTSFWKNSKALNQIKSSCKKIHLDANLLVVDYPSDFVKSVTCQVCEHILSDPVQTACKHLFCRSCILKYIKIMGCYCPACRYTCFPTDFTTPVKSYLNILNSLVLKCTVAECDEEVTLGKYSHHISKHKEIKGKEAYAHINKGGRPRQHLLSLTRRAQKHRLRE","length":360,"molWeight":41475,"crc64":"09146697CE6CDCFB","md5":"0F0F627242F761261291C0A09AEBCB5D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":3,"Region":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF78"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1K9","uniProtkbId":"B0I1K9_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":79,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99779.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021277"}],"value":"V(D)J recombination-activating protein 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012483"}],"value":"2.3.2.27"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99779.1"}],"value":"RAG1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000900"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001936"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Belongs to the RAG1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50089"}]},{"type":"Domain","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"RAG1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51765"}]},{"type":"Domain","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"NBD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51487"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99779.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99779.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022759"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022722"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01101"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99779.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277333","properties":[{"key":"ProteinId","value":"BAF99779.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"GO","id":"GO:0097519","properties":[{"key":"GoTerm","value":"C:DNA recombinase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1905347","properties":[{"key":"GoTerm","value":"C:endodeoxyribonuclease complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:1990238","properties":[{"key":"GoTerm","value":"F:double-stranded DNA endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0033151","properties":[{"key":"GoTerm","value":"P:V(D)J recombination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd16530","properties":[{"key":"EntryName","value":"RING-HC_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000142","properties":[{"key":"EntryName","value":"Recombination activating gene 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.140.510","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024627","properties":[{"key":"EntryName","value":"RAG1"}]},{"database":"InterPro","id":"IPR035714","properties":[{"key":"EntryName","value":"RAG1_imp-bd"}]},{"database":"InterPro","id":"IPR019485","properties":[{"key":"EntryName","value":"RAG1_Znf"}]},{"database":"InterPro","id":"IPR023336","properties":[{"key":"EntryName","value":"RAG_nonamer-bd_dom"}]},{"database":"InterPro","id":"IPR058558","properties":[{"key":"EntryName","value":"RING-HC_RAG1"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR018957","properties":[{"key":"EntryName","value":"Znf_C3HC4_RING-type"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR11539:SF0","properties":[{"key":"EntryName","value":"V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11539","properties":[{"key":"EntryName","value":"VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12560","properties":[{"key":"EntryName","value":"RAG1_imp_bd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00097","properties":[{"key":"EntryName","value":"zf-C3HC4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10426","properties":[{"key":"EntryName","value":"zf-RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51487","properties":[{"key":"EntryName","value":"NBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51765","properties":[{"key":"EntryName","value":"ZF_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"ETSPYFNVSSDDLNLTTSSQSHSECMSQEENMVDNEDNDSSLKRMXEDTHTSILQHLCRICGISFKMDQQNRNYPVHGPVDDETQEVLRRREKKATSWPELISKVFKVDVRGDMDTIHPTRFCHNCWTIMHQKFSNTSNEVYFPRNKVVEWKSHSSTCDVCSNSKTWGKRKGGLIQSSLLPKKRKISIEHGKKSKNGNTTSFWKNSKALNQIKTSCKKIHLDANLLVVDYPSDFVKSVTCQVCEHILSDPVQTACKHLFCRSCILKYIKIMGCYCPACRYTCFPTDFTTPVKSYLNILNSLVLKCTVAECDEEVTLGKYSHHISKHKEIKGKEAYAHINKGGRPRQHLLSLTRRAQKHRL","length":360,"molWeight":41337,"crc64":"FFF27AB86FC9E0D1","md5":"49512D9391EFBC28F475943491FCD3CF"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI000163DF75"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1L0","uniProtkbId":"B0I1L0_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":73,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99780.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021277"}],"value":"V(D)J recombination-activating protein 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012483"}],"value":"2.3.2.27"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99780.1"}],"value":"RAG1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000900"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001936"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Belongs to the RAG1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50089"}]},{"type":"Domain","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"RAG1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51765"}]},{"type":"Domain","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"NBD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51487"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99780.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99780.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022759"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022722"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01101"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99780.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277334","properties":[{"key":"ProteinId","value":"BAF99780.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1L0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0097519","properties":[{"key":"GoTerm","value":"C:DNA recombinase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1905347","properties":[{"key":"GoTerm","value":"C:endodeoxyribonuclease complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:1990238","properties":[{"key":"GoTerm","value":"F:double-stranded DNA endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0033151","properties":[{"key":"GoTerm","value":"P:V(D)J recombination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd16530","properties":[{"key":"EntryName","value":"RING-HC_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000142","properties":[{"key":"EntryName","value":"Recombination activating gene 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024627","properties":[{"key":"EntryName","value":"RAG1"}]},{"database":"InterPro","id":"IPR035714","properties":[{"key":"EntryName","value":"RAG1_imp-bd"}]},{"database":"InterPro","id":"IPR019485","properties":[{"key":"EntryName","value":"RAG1_Znf"}]},{"database":"InterPro","id":"IPR023336","properties":[{"key":"EntryName","value":"RAG_nonamer-bd_dom"}]},{"database":"InterPro","id":"IPR058558","properties":[{"key":"EntryName","value":"RING-HC_RAG1"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR018957","properties":[{"key":"EntryName","value":"Znf_C3HC4_RING-type"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR11539:SF0","properties":[{"key":"EntryName","value":"V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11539","properties":[{"key":"EntryName","value":"VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12560","properties":[{"key":"EntryName","value":"RAG1_imp_bd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00097","properties":[{"key":"EntryName","value":"zf-C3HC4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10426","properties":[{"key":"EntryName","value":"zf-RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51487","properties":[{"key":"EntryName","value":"NBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51765","properties":[{"key":"EntryName","value":"ZF_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"THTSILQHLCRICGISFKMDQQNRNYPVHGPVDDETQEVLRRREKKATSWPELISKVFKVDVRGDMDTIHPTRFCHNCWTIMHQKFSNTSNEVYFPRNKVVEWKSHSSTCDVCSNSKTWGKRKGGLIQSSLLPKKCKISIEHGKKSKNGNTTSFWKNSKALNQIKTSCKKIHLDANLLVVDYPSDFVKSVTCQVCEHILSDPVQTACKHLFCRSCILKYIKIMGCYCPACRYTCFPTDFTTPVKSYLNILNSLVLKCTVAECDEEVTLGKYSHHISKHKEIKGKEAYAHINKGGRPRQHLLS","length":302,"molWeight":34583,"crc64":"D581BA444E6E6025","md5":"CDD3F5E5637890F8CC338485854BF70B"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI000163DF76"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1L1","uniProtkbId":"B0I1L1_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":80,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99781.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021277"}],"value":"V(D)J recombination-activating protein 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012483"}],"value":"2.3.2.27"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99781.1"}],"value":"RAG1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000900"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001936"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Belongs to the RAG1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50089"}]},{"type":"Domain","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"RAG1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51765"}]},{"type":"Domain","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"NBD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51487"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99781.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99781.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022759"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022722"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01101"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99781.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277335","properties":[{"key":"ProteinId","value":"BAF99781.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"GO","id":"GO:0097519","properties":[{"key":"GoTerm","value":"C:DNA recombinase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1905347","properties":[{"key":"GoTerm","value":"C:endodeoxyribonuclease complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:1990238","properties":[{"key":"GoTerm","value":"F:double-stranded DNA endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0033151","properties":[{"key":"GoTerm","value":"P:V(D)J recombination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd16530","properties":[{"key":"EntryName","value":"RING-HC_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000142","properties":[{"key":"EntryName","value":"Recombination activating gene 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.140.510","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024627","properties":[{"key":"EntryName","value":"RAG1"}]},{"database":"InterPro","id":"IPR035714","properties":[{"key":"EntryName","value":"RAG1_imp-bd"}]},{"database":"InterPro","id":"IPR019485","properties":[{"key":"EntryName","value":"RAG1_Znf"}]},{"database":"InterPro","id":"IPR023336","properties":[{"key":"EntryName","value":"RAG_nonamer-bd_dom"}]},{"database":"InterPro","id":"IPR058558","properties":[{"key":"EntryName","value":"RING-HC_RAG1"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR018957","properties":[{"key":"EntryName","value":"Znf_C3HC4_RING-type"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR11539:SF0","properties":[{"key":"EntryName","value":"V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11539","properties":[{"key":"EntryName","value":"VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12560","properties":[{"key":"EntryName","value":"RAG1_imp_bd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00097","properties":[{"key":"EntryName","value":"zf-C3HC4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10426","properties":[{"key":"EntryName","value":"zf-RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51487","properties":[{"key":"EntryName","value":"NBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51765","properties":[{"key":"EntryName","value":"ZF_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SQEEQDDSGLSCTSSQETSPYFNVSSDDLNLTTSSQSHSECTSQEENMVDNEDNDSSLKRMEEDTHTSILQHLCRICGISFKMDQQNRNYPVHGPVDDETQEVLRRREKKATSXPELISKVFKVDVRGDMDTIHPTRFCHNCWTIMHQKFSNTSNEVYFPRNKVVEWKSHSSTCDVCSNSKTWGKRKGGLIQSSLLPKKRKISIEHGKKSKNGNTTSFWKNSKALNQIKTSCKKIHLDANLLVVDYPSDFVKSVTCQVCEHILSDPVQTACKHLFCRSCILKYIKIMGCYCPACRYTCFPTDFTTPVKSYLNILNSLVLKCTVAECDEEVTLGKYSHHISKHKEIKGKEAYAHINKGGRPRQHLLSLTRRAQKHRL","length":376,"molWeight":42933,"crc64":"7E6181F02081B972","md5":"BFE1FE962016A1B185D5944F035A26CF"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":3,"Region":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF77"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1L3","uniProtkbId":"B0I1L3_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":75,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99783.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021277"}],"value":"V(D)J recombination-activating protein 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012483"}],"value":"2.3.2.27"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99783.1"}],"value":"RAG1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000900"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001936"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Belongs to the RAG1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50089"}]},{"type":"Domain","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"RAG1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51765"}]},{"type":"Domain","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"NBD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51487"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99783.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":331,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99783.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022759"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022722"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01101"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99783.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277337","properties":[{"key":"ProteinId","value":"BAF99783.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"GO","id":"GO:0097519","properties":[{"key":"GoTerm","value":"C:DNA recombinase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1905347","properties":[{"key":"GoTerm","value":"C:endodeoxyribonuclease complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:1990238","properties":[{"key":"GoTerm","value":"F:double-stranded DNA endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0033151","properties":[{"key":"GoTerm","value":"P:V(D)J recombination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd16530","properties":[{"key":"EntryName","value":"RING-HC_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000142","properties":[{"key":"EntryName","value":"Recombination activating gene 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024627","properties":[{"key":"EntryName","value":"RAG1"}]},{"database":"InterPro","id":"IPR035714","properties":[{"key":"EntryName","value":"RAG1_imp-bd"}]},{"database":"InterPro","id":"IPR019485","properties":[{"key":"EntryName","value":"RAG1_Znf"}]},{"database":"InterPro","id":"IPR023336","properties":[{"key":"EntryName","value":"RAG_nonamer-bd_dom"}]},{"database":"InterPro","id":"IPR058558","properties":[{"key":"EntryName","value":"RING-HC_RAG1"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR018957","properties":[{"key":"EntryName","value":"Znf_C3HC4_RING-type"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR11539:SF0","properties":[{"key":"EntryName","value":"V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11539","properties":[{"key":"EntryName","value":"VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12560","properties":[{"key":"EntryName","value":"RAG1_imp_bd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00097","properties":[{"key":"EntryName","value":"zf-C3HC4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10426","properties":[{"key":"EntryName","value":"zf-RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51487","properties":[{"key":"EntryName","value":"NBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51765","properties":[{"key":"EntryName","value":"ZF_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SSQSHSECXSQEENMVDNEDNDSSLKRMEEETHTSILQHLCRICGISFKMDQQNRNYPVHGPVDDETQEVLRRREKKATSWPELISKVFKVDVRGDMDTIHPTRFCHNCWTIMHQKFSNTSSEVYFPRNKVVEWKSHSSTCDVCNNSKTWGKRKGGLIQSSLLPKKRKISIEHGKKXKNGNTTSFWKNSKALNQIKXSCKKIHLDANLLVVDYPSDFVKSVTCQVCEHILSDPVQTACKHLFCRSCILKYIKIMGCYCPACRYTCFPTDFTTPVKSYLNILNSLVLKCTVAECDEEVTLGKYSHHISKHKEIKGKEAYAHINKGGRPRQHL","length":331,"molWeight":38038,"crc64":"8E2EF297BD8B7A9B","md5":"555ACABDE65EF0A15B0B97A5C9843595"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":3,"Region":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF79"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1L4","uniProtkbId":"B0I1L4_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":80,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99784.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021277"}],"value":"V(D)J recombination-activating protein 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012483"}],"value":"2.3.2.27"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99784.1"}],"value":"RAG1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000900"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001936"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]}],"features":[{"type":"Domain","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50089"}]},{"type":"Domain","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"RAG1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51765"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99784.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99784.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022759"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022722"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01101"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99784.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277338","properties":[{"key":"ProteinId","value":"BAF99784.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"GO","id":"GO:0097519","properties":[{"key":"GoTerm","value":"C:DNA recombinase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1905347","properties":[{"key":"GoTerm","value":"C:endodeoxyribonuclease complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1990238","properties":[{"key":"GoTerm","value":"F:double-stranded DNA endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0033151","properties":[{"key":"GoTerm","value":"P:V(D)J recombination"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd16530","properties":[{"key":"EntryName","value":"RING-HC_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000142","properties":[{"key":"EntryName","value":"Recombination activating gene 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024627","properties":[{"key":"EntryName","value":"RAG1"}]},{"database":"InterPro","id":"IPR035714","properties":[{"key":"EntryName","value":"RAG1_imp-bd"}]},{"database":"InterPro","id":"IPR019485","properties":[{"key":"EntryName","value":"RAG1_Znf"}]},{"database":"InterPro","id":"IPR058558","properties":[{"key":"EntryName","value":"RING-HC_RAG1"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR018957","properties":[{"key":"EntryName","value":"Znf_C3HC4_RING-type"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR11539:SF0","properties":[{"key":"EntryName","value":"V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11539","properties":[{"key":"EntryName","value":"VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12560","properties":[{"key":"EntryName","value":"RAG1_imp_bd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00097","properties":[{"key":"EntryName","value":"zf-C3HC4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10426","properties":[{"key":"EntryName","value":"zf-RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51765","properties":[{"key":"EntryName","value":"ZF_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SPYFNFSSDDLNLTTSSQSHSECMSQEENMVDNEDNDSSLKRIEEETHTSILQHLCRICGVSFKMDQQNRNYPVHGPVDDETQEVLRRREKKATSWPELISKVFKVDVRGDMDTIHPTRFCHNCWTIMHQKFSNTSSEVYFPRNKVVEWKSHXXTCDVCNNSKTWGKRKGGLIQSSLLPKKRKISIEHGKKNKNGTTTSFWKNSKALNQIKSSCKKIHLDANLLVVDYPSDFVKSVTCQVCEHILSDPVQTACKHLFCRSCILKYIKIMGCYCPACRYTCFPTDFTTPVKSYLNILNSLVLKCTVAECDEEVTLGKYSHHISKHKEIKGKEAYAHINKG","length":339,"molWeight":38898,"crc64":"1921CDE44A9D1922","md5":"C3604841A2C322B3196650F4EE2BBBC8"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2},"countByFeatureType":{"Domain":2,"Region":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF7A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1L6","uniProtkbId":"B0I1L6_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":78,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99786.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021277"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"V(D)J recombination-activating protein 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012483"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"2.3.2.27"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"3.1.-.-"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99786.1"}],"value":"RAG1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000900"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+)."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"value":"Belongs to the RAG1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50089"}]},{"type":"Domain","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"RAG1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51765"}]},{"type":"Domain","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"NBD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51487"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99786.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99786.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022759"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022722"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00820"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU366024"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01101"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99786.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277340","properties":[{"key":"ProteinId","value":"BAF99786.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1L6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0097519","properties":[{"key":"GoTerm","value":"C:DNA recombinase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1905347","properties":[{"key":"GoTerm","value":"C:endodeoxyribonuclease complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:1990238","properties":[{"key":"GoTerm","value":"F:double-stranded DNA endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042393","properties":[{"key":"GoTerm","value":"F:histone binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0030183","properties":[{"key":"GoTerm","value":"P:B cell differentiation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0033077","properties":[{"key":"GoTerm","value":"P:T cell differentiation in thymus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0033151","properties":[{"key":"GoTerm","value":"P:V(D)J recombination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd16530","properties":[{"key":"EntryName","value":"RING-HC_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000142","properties":[{"key":"EntryName","value":"Recombination activating gene 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.140.510","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024627","properties":[{"key":"EntryName","value":"RAG1"}]},{"database":"InterPro","id":"IPR035714","properties":[{"key":"EntryName","value":"RAG1_imp-bd"}]},{"database":"InterPro","id":"IPR019485","properties":[{"key":"EntryName","value":"RAG1_Znf"}]},{"database":"InterPro","id":"IPR023336","properties":[{"key":"EntryName","value":"RAG_nonamer-bd_dom"}]},{"database":"InterPro","id":"IPR058558","properties":[{"key":"EntryName","value":"RING-HC_RAG1"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR018957","properties":[{"key":"EntryName","value":"Znf_C3HC4_RING-type"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR11539:SF0","properties":[{"key":"EntryName","value":"V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11539","properties":[{"key":"EntryName","value":"VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12940","properties":[{"key":"EntryName","value":"RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12560","properties":[{"key":"EntryName","value":"RAG1_imp_bd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00097","properties":[{"key":"EntryName","value":"zf-C3HC4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10426","properties":[{"key":"EntryName","value":"zf-RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51487","properties":[{"key":"EntryName","value":"NBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51765","properties":[{"key":"EntryName","value":"ZF_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"AHTSILQHLCRICGISFKMDQQSRSYPVHGPVDDETQEILRRKEKKATSWPELISKVFKVDVRSDLDTIHPTRFCHNCWTIMHQKFSNSSSEVYFPRNKAVEWKSHSSTCDICNNSKTWGKRKGGLLQSSLLPKKRKISIEHGKKNKNGNTTSFWKNSKALNQIKTSCKKIHLDASLLVVDYPSDFVKSVTCQVCEHILSDPVQTACKHLFCRSCILKYIKIMGCYCPACRYTCFPTDFTTPVKSYLNILNSLVLKCTVAECNEEVTLGKYSHHISKHKEIKGKEAYAHINKGGRPRQHLLSLTRRAQKHRLE","length":313,"molWeight":35911,"crc64":"12630D154F7AD49C","md5":"48FCDD9199376D01E468F3EF87667D2B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI000163DF7C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1L7","uniProtkbId":"B0I1L7_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":83,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99787.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00021277"}],"value":"V(D)J recombination-activating protein 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012483"}],"value":"2.3.2.27"}]},"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99787.1"}],"value":"RAG1"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00000900"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001946"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001936"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}]}],"features":[{"type":"Domain","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50089"}]},{"type":"Domain","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"RAG1-type","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51765"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99787.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99787.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022853"}],"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023172"}],"id":"KW-0233","category":"Biological process","name":"DNA recombination"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022759"}],"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022801"}],"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023268"}],"id":"KW-0511","category":"Molecular function","name":"Multifunctional enzyme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022722"}],"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022679"}],"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022786"}],"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022833"}],"id":"KW-0862","category":"Ligand","name":"Zinc"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022771"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU01101"}],"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99787.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277341","properties":[{"key":"ProteinId","value":"BAF99787.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1L7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0097519","properties":[{"key":"GoTerm","value":"C:DNA recombinase complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1905347","properties":[{"key":"GoTerm","value":"C:endodeoxyribonuclease complex"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:1990238","properties":[{"key":"GoTerm","value":"F:double-stranded DNA endonuclease activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0043565","properties":[{"key":"GoTerm","value":"F:sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0033151","properties":[{"key":"GoTerm","value":"P:V(D)J recombination"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd16530","properties":[{"key":"EntryName","value":"RING-HC_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.40.10:FF:000142","properties":[{"key":"EntryName","value":"Recombination activating gene 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.60","properties":[{"key":"EntryName","value":"Classic Zinc Finger"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR024627","properties":[{"key":"EntryName","value":"RAG1"}]},{"database":"InterPro","id":"IPR035714","properties":[{"key":"EntryName","value":"RAG1_imp-bd"}]},{"database":"InterPro","id":"IPR019485","properties":[{"key":"EntryName","value":"RAG1_Znf"}]},{"database":"InterPro","id":"IPR058558","properties":[{"key":"EntryName","value":"RING-HC_RAG1"}]},{"database":"InterPro","id":"IPR036236","properties":[{"key":"EntryName","value":"Znf_C2H2_sf"}]},{"database":"InterPro","id":"IPR018957","properties":[{"key":"EntryName","value":"Znf_C3HC4_RING-type"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR11539:SF0","properties":[{"key":"EntryName","value":"V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11539","properties":[{"key":"EntryName","value":"VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12560","properties":[{"key":"EntryName","value":"RAG1_imp_bd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00097","properties":[{"key":"EntryName","value":"zf-C3HC4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10426","properties":[{"key":"EntryName","value":"zf-RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57667","properties":[{"key":"EntryName","value":"beta-beta-alpha zinc fingers"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51765","properties":[{"key":"EntryName","value":"ZF_RAG1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"DDLNLTTSSQSHSECMSQEENMVDNEDNDSSLKRIEEETHTSILQHLCRICGVSFKMDQQNRNYPVHGPVDDETQEVLRRREKKATSWPELISKVFKVDVRGDMDTIHPTRFCHNCWTIMHQKFSNTSSEVYFPRNKVVEWKSHSSTCDVCNNSKTWGKRKGGLIQSSLLPKKRKISIEHGKKNKNGNTTSFWKNSKALNQIKSSCKKIHLDANLLVVEYPSDFVKSVTCQVCEHILSDPVQTACKHLFCRSCILKYIKIMGCYCPACRYTCFPTDFTTPVKSYLNILNSLVLKCTVAECDEEVTLGKYSHHISKHKEIKGKE","length":323,"molWeight":37091,"crc64":"F54089E078071C41","md5":"C68D9F7B65C675DADFBC0BE66E41CC61"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":1,"COFACTOR":2},"countByFeatureType":{"Domain":2,"Region":1,"Compositional bias":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF7D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q7YA21","uniProtkbId":"Q7YA21_FEJLI","entryAudit":{"firstPublicDate":"2003-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-10-01","entryVersion":114,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO12109.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00015947"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Cytochrome c oxidase subunit 1"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00012949"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"7.1.1.9"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO12109.1"}],"value":"COI"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:11436"},{"database":"Rhea","id":"RHEA-COMP:10350"},{"database":"Rhea","id":"RHEA-COMP:14399"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:29033"},{"database":"ChEBI","id":"CHEBI:29034"}],"ecNumber":"7.1.1.9","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:11437"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00049512"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Cu cation","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001935"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:23378"}}]},{"commentType":"COFACTOR","cofactors":[{"name":"heme","evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00001971"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:30413"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004673"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Energy metabolism; oxidative phosphorylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009578"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"value":"Belongs to the heme-copper respiratory oxidase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":455,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Cytochrome oxidase subunit I profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50855"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO12109.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023008"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0186","category":"Ligand","name":"Copper"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022842"}],"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023053"}],"id":"KW-0915","category":"Ligand","name":"Sodium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022967"}],"id":"KW-1278","category":"Molecular function","name":"Translocase"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000369"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-6HI969ITRG6TH","citationType":"submission","authors":["Liu Z.","Wang Y.","Zhou K."],"publicationDate":"OCT-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO12109.1"}]},{"referenceNumber":2,"citation":{"id":"15716031","citationType":"journal article","authors":["Liu Z.Q.","Wang Y.Q.","Su B."],"citationCrossReferences":[{"database":"PubMed","id":"15716031"},{"database":"DOI","id":"10.1016/j.gene.2004.10.013"}],"title":"The mitochondrial genome organization of the rice frog, Fejervarya limnocharis (Amphibia: Anura): a new gene order in the vertebrate mtDNA.","publicationDate":"2005","journal":"Gene","firstPage":"145","lastPage":"151","volume":"346"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAO12109.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY158705","properties":[{"key":"ProteinId","value":"AAO12109.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q7YA21","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00705","properties":[{"key":"RectionId","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0045277","properties":[{"key":"GoTerm","value":"C:respiratory chain complex IV"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004129","properties":[{"key":"GoTerm","value":"F:cytochrome-c oxidase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-EC"}]},{"database":"GO","id":"GO:0020037","properties":[{"key":"GoTerm","value":"F:heme binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0015990","properties":[{"key":"GoTerm","value":"P:electron transport coupled proton transport"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006123","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, cytochrome c to oxygen"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd01663","properties":[{"key":"EntryName","value":"Cyt_c_Oxidase_I"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.210.10:FF:000001","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.210.10","properties":[{"key":"EntryName","value":"Cytochrome c oxidase-like, subunit I domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023616","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_dom"}]},{"database":"InterPro","id":"IPR036927","properties":[{"key":"EntryName","value":"Cyt_c_oxase-like_su1_sf"}]},{"database":"InterPro","id":"IPR000883","properties":[{"key":"EntryName","value":"Cyt_C_Oxase_1"}]},{"database":"InterPro","id":"IPR023615","properties":[{"key":"EntryName","value":"Cyt_c_Oxase_su1_BS"}]},{"database":"InterPro","id":"IPR033944","properties":[{"key":"EntryName","value":"Cyt_c_oxase_su1_dom"}]},{"database":"PANTHER","id":"PTHR10422","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10422:SF18","properties":[{"key":"EntryName","value":"CYTOCHROME C OXIDASE SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00115","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01165","properties":[{"key":"EntryName","value":"CYCOXIDASEI"}]},{"database":"SUPFAM","id":"SSF81442","properties":[{"key":"EntryName","value":"Cytochrome c oxidase subunit I-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50855","properties":[{"key":"EntryName","value":"COX1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00077","properties":[{"key":"EntryName","value":"COX1_CUB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFSRWLFSTNHKDIGTMYLIFGAWAGMTGTALSLLIRAELSQPGALLGDDQIYNVVVTAHAFVMIFFMVMPILIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFFLLLASSTVEAGAGTGWTVYPPLAGNLAHAGPSVDLAIFSLHLAGVSSILGAINFITTIINMKPPSTTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVAYYSTKKEPFGYMGMVWAMLSIGLLGFIVWAHHMFTTDLNVDTRAYFTSATMIIAIPTGVKVFSWLATMYGGIIKWEAPMLWALGFIFLFTVGGLTGIVLANSSIDIVLHDTYYVGAHFHYVLSMGAVFAIMAGFVHWFPLFTGFTFHKTWAKAQFAVMFTGVNVTFFPQHFLGLAGMPRRYSDYPDAYALWNTISSMGSLISLVGVIMLMFIIWEAFSSKRLFSNPKLTTTNIEWLLGFPPQHHTFEASFLLI","length":511,"molWeight":56553,"crc64":"468C3ED1E83B5955","md5":"4B7C6F027933A2D8F987DADCAD9566D8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":2,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":12,"Domain":1},"uniParcId":"UPI00001B5DE7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7M6L5","uniProtkbId":"A7M6L5_FEJLI","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-10-02","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76055.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"}],"value":"Cytochrome b"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031681"}],"value":"Complex III subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032600"}],"value":"Complex III subunit III"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029812"}],"value":"Cytochrome b-c1 complex subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032818"}],"value":"Ubiquinol-cytochrome-c reductase complex cytochrome b subunit"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76055.1"}],"value":"cytb"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002566"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76055.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76055.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76055.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76055.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"18271636","citationType":"journal article","authors":["Djong T.H.","Matsui M.","Kuramoto M.","Belabut D.M.","Sen Y.H.","Nishioka M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18271636"},{"database":"DOI","id":"10.2108/zsj.24.1197"}],"title":"Morphological divergence, reproductive isolating mechanism, and molecular phylogenetic relationships among Indonesia, Malaysia, and Japan populations of the Fejervarya limnocharis complex (Anura, Ranidae).","publicationDate":"2007","journal":"Zool. Sci.","firstPage":"1197","lastPage":"1212","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76055.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76055.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB296087","properties":[{"key":"ProteinId","value":"BAF76055.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB296088","properties":[{"key":"ProteinId","value":"BAF76056.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7M6L5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VNNGWLLRNLHANGASFFFICIYLHIGRGLYYGSFLYKETWNTGIILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAAPYIGNDLVQWIWGGFSVDNATLTRFFSFHFVFPFAIAGASMIHLLFLHQTGSSNPTGLNQNLDKVPFHPYFSYKDLLGFVILIGLLATLSTFAPNLLGDPDNFTPANPLVTPPHI","length":196,"molWeight":21845,"crc64":"B385035AC5F28843","md5":"84B46D5FD752646F261E82C9339546AE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":4,"Domain":2,"Binding site":4,"Non-terminal residue":2},"uniParcId":"UPI00015BF9F0"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7M6L7","uniProtkbId":"A7M6L7_FEJLI","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-10-02","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76057.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"}],"value":"Cytochrome b"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031681"}],"value":"Complex III subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032600"}],"value":"Complex III subunit III"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029812"}],"value":"Cytochrome b-c1 complex subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032818"}],"value":"Ubiquinol-cytochrome-c reductase complex cytochrome b subunit"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76057.1"}],"value":"cytb"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002566"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76057.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76057.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76057.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76057.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"18271636","citationType":"journal article","authors":["Djong T.H.","Matsui M.","Kuramoto M.","Belabut D.M.","Sen Y.H.","Nishioka M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18271636"},{"database":"DOI","id":"10.2108/zsj.24.1197"}],"title":"Morphological divergence, reproductive isolating mechanism, and molecular phylogenetic relationships among Indonesia, Malaysia, and Japan populations of the Fejervarya limnocharis complex (Anura, Ranidae).","publicationDate":"2007","journal":"Zool. Sci.","firstPage":"1197","lastPage":"1212","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76057.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76057.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB296089","properties":[{"key":"ProteinId","value":"BAF76057.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7M6L7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VNNGWVLRNLHANGASFFFICIYLHIGRGLYYGSFLYKETWNTGIILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAAPYIGNDLVQWIWGGFSVDNATLTRFFSFHFVFPFAIAGASMIHLLFLHQTGSSNPTGLNQNLDKVPFHPYFSYKDLLGFVILIGLLATLSTFAPNLLGDPDNFTPANPLVTPPHI","length":196,"molWeight":21831,"crc64":"BA8BF85D25E767B9","md5":"C0530F6612BF7DB88546BF75C2E8BD4D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":4,"Domain":2,"Binding site":4,"Non-terminal residue":2},"uniParcId":"UPI00015BF9F1"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7M6L8","uniProtkbId":"A7M6L8_FEJLI","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-10-02","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76058.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"}],"value":"Cytochrome b"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031681"}],"value":"Complex III subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032600"}],"value":"Complex III subunit III"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029812"}],"value":"Cytochrome b-c1 complex subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032818"}],"value":"Ubiquinol-cytochrome-c reductase complex cytochrome b subunit"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76058.1"}],"value":"cytb"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002566"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76058.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76058.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76058.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76058.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"18271636","citationType":"journal article","authors":["Djong T.H.","Matsui M.","Kuramoto M.","Belabut D.M.","Sen Y.H.","Nishioka M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18271636"},{"database":"DOI","id":"10.2108/zsj.24.1197"}],"title":"Morphological divergence, reproductive isolating mechanism, and molecular phylogenetic relationships among Indonesia, Malaysia, and Japan populations of the Fejervarya limnocharis complex (Anura, Ranidae).","publicationDate":"2007","journal":"Zool. Sci.","firstPage":"1197","lastPage":"1212","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76058.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76058.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB296090","properties":[{"key":"ProteinId","value":"BAF76058.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7M6L8","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VNNGWVLRNLHANGASFFFIWIYLHIGRGLYYGSFLYKETWNTGIILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAAPYIGNDLVQWIWGGFSVDNATLTRFFSFHFVFPFAIAGASMIHLLFLHQTGSSNPTGLNQNLDKVPFHPYFSYKDLLGFVILIGLLATLSTFAPNLLGDPDNFTPANPLVTPPHI","length":196,"molWeight":21914,"crc64":"CC5FEC52533C1169","md5":"1F95EB18D3739C3D973EDE901E58E169"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":4,"Domain":2,"Binding site":4,"Non-terminal residue":2},"uniParcId":"UPI00015BF9F2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7M6L9","uniProtkbId":"A7M6L9_FEJLI","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-10-02","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76059.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"}],"value":"Cytochrome b"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031681"}],"value":"Complex III subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032600"}],"value":"Complex III subunit III"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029812"}],"value":"Cytochrome b-c1 complex subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032818"}],"value":"Ubiquinol-cytochrome-c reductase complex cytochrome b subunit"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76059.1"}],"value":"cytb"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002566"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76059.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76059.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76059.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76059.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"18271636","citationType":"journal article","authors":["Djong T.H.","Matsui M.","Kuramoto M.","Belabut D.M.","Sen Y.H.","Nishioka M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18271636"},{"database":"DOI","id":"10.2108/zsj.24.1197"}],"title":"Morphological divergence, reproductive isolating mechanism, and molecular phylogenetic relationships among Indonesia, Malaysia, and Japan populations of the Fejervarya limnocharis complex (Anura, Ranidae).","publicationDate":"2007","journal":"Zool. Sci.","firstPage":"1197","lastPage":"1212","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76059.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB296091","properties":[{"key":"ProteinId","value":"BAF76059.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7M6L9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VNNGWGLRNLHANGASFFFICIYLHIGRGLYYGSFLYKETWNTGIILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAAPYIGNDLVQWIWGGFSVDNATLTRFFSFHFVFPFAIAGASMIHLLFLHQTGSSNPTGLNQNLDKVPFHPYFSYKDLLGFVILIGLLATLSTFAPNLLGDPDNFTPANPLVTPPHI","length":196,"molWeight":21789,"crc64":"B53BE2E295FDDC18","md5":"A592A3D675D9EA22FDEBE446B54103A7"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":4,"Domain":2,"Binding site":4,"Non-terminal residue":2},"uniParcId":"UPI00015BF9F3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7M6M0","uniProtkbId":"A7M6M0_FEJLI","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-10-02","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76060.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"}],"value":"Cytochrome b"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031681"}],"value":"Complex III subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032600"}],"value":"Complex III subunit III"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029812"}],"value":"Cytochrome b-c1 complex subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032818"}],"value":"Ubiquinol-cytochrome-c reductase complex cytochrome b subunit"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76060.1"}],"value":"cytb"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002566"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76060.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76060.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76060.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76060.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"18271636","citationType":"journal article","authors":["Djong T.H.","Matsui M.","Kuramoto M.","Belabut D.M.","Sen Y.H.","Nishioka M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18271636"},{"database":"DOI","id":"10.2108/zsj.24.1197"}],"title":"Morphological divergence, reproductive isolating mechanism, and molecular phylogenetic relationships among Indonesia, Malaysia, and Japan populations of the Fejervarya limnocharis complex (Anura, Ranidae).","publicationDate":"2007","journal":"Zool. Sci.","firstPage":"1197","lastPage":"1212","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76060.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76060.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB296092","properties":[{"key":"ProteinId","value":"BAF76060.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7M6M0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VNNSWLLRNLHANGASFFFIWIYLHIGRGLYYGSFLYKETWNTGIILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAAPYIGNDLVQWIWGGFSVDNATLTRFFSFHFVFPFAIAGASMIHLLFLHQTGSSNPTGLNQNLDKVPFHPYFSYKDLLGFVILIGLLATLSTFAPNLLGDPDNFTPANPLVTPPHI","length":196,"molWeight":21958,"crc64":"7DC8DBC0FBB03E8E","md5":"11337C1E35658BC9D95CAE156A33827B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":4,"Domain":2,"Binding site":4,"Non-terminal residue":2},"uniParcId":"UPI00015BF9F4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7M6M1","uniProtkbId":"A7M6M1_FEJLI","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-10-02","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76061.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"}],"value":"Cytochrome b"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031681"}],"value":"Complex III subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032600"}],"value":"Complex III subunit III"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029812"}],"value":"Cytochrome b-c1 complex subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032818"}],"value":"Ubiquinol-cytochrome-c reductase complex cytochrome b subunit"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76061.1"}],"value":"cytb"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002566"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76061.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76061.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76061.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76061.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"18271636","citationType":"journal article","authors":["Djong T.H.","Matsui M.","Kuramoto M.","Belabut D.M.","Sen Y.H.","Nishioka M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18271636"},{"database":"DOI","id":"10.2108/zsj.24.1197"}],"title":"Morphological divergence, reproductive isolating mechanism, and molecular phylogenetic relationships among Indonesia, Malaysia, and Japan populations of the Fejervarya limnocharis complex (Anura, Ranidae).","publicationDate":"2007","journal":"Zool. Sci.","firstPage":"1197","lastPage":"1212","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76061.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76061.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB296093","properties":[{"key":"ProteinId","value":"BAF76061.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7M6M1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VNNGWLLRNLHANGAFFFFICIYLHIGRGLYYGSFLYKETWNTGIILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAAPYIGNDLVQWIWGGFSVDNATLTRFFSFHFVFPFAIAGASMIHLLFLHQTGSSNPTGLNQNLDKVPFHPYFSYKDLLGFVILIGLLATLSTFAPNLLGDPDNFTPANPLVTPPHI","length":196,"molWeight":21905,"crc64":"5AE0034FCA4287FC","md5":"148A9ABDE1A83158752A63B3D091C4DD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":4,"Domain":2,"Binding site":4,"Non-terminal residue":2},"uniParcId":"UPI00015BF9F5"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7M6M3","uniProtkbId":"A7M6M3_FEJLI","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-10-02","entryVersion":63,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76063.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"}],"value":"Cytochrome b"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031681"}],"value":"Complex III subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032600"}],"value":"Complex III subunit III"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029812"}],"value":"Cytochrome b-c1 complex subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032818"}],"value":"Ubiquinol-cytochrome-c reductase complex cytochrome b subunit"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76063.1"}],"value":"cytb"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002566"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76063.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76063.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76063.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76063.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"18271636","citationType":"journal article","authors":["Djong T.H.","Matsui M.","Kuramoto M.","Belabut D.M.","Sen Y.H.","Nishioka M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18271636"},{"database":"DOI","id":"10.2108/zsj.24.1197"}],"title":"Morphological divergence, reproductive isolating mechanism, and molecular phylogenetic relationships among Indonesia, Malaysia, and Japan populations of the Fejervarya limnocharis complex (Anura, Ranidae).","publicationDate":"2007","journal":"Zool. Sci.","firstPage":"1197","lastPage":"1212","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76063.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76063.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB296095","properties":[{"key":"ProteinId","value":"BAF76063.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7M6M3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VNNSWRLGNLHGNEDSVLCICIDLHIGRGLYYGSFLYKETWNTGIILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAAPYIGNDLVQWIWGGFSVDNATLTRFFSFHFVFPFAIAGASMIHLLFLHQTGSSNPTGLNQNLDKVPFHPYFSYKDLLGFVILIGLLAALSTFAPNLLGDPDNFTPANPLVTPPHI","length":196,"molWeight":21717,"crc64":"9EE6F7F3A798A541","md5":"D3B5BF5EFB2FB9F97C42CF2F96060C13"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":3,"Domain":2,"Binding site":4,"Non-terminal residue":2},"uniParcId":"UPI00015BF9F7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7M6M4","uniProtkbId":"A7M6M4_FEJLI","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2007-10-02","entryVersion":63,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76064.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00013531"}],"value":"Cytochrome b"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00031681"}],"value":"Complex III subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032600"}],"value":"Complex III subunit III"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00029812"}],"value":"Cytochrome b-c1 complex subunit 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00032818"}],"value":"Ubiquinol-cytochrome-c reductase complex cytochrome b subunit"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76064.1"}],"value":"cytb"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00002566"}],"value":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004448"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"value":"Belongs to the cytochrome b family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Cytochrome b/b6 N-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51002"}]},{"type":"Domain","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Cytochrome b/b6 C-terminal region profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51003"}]},{"type":"Binding site","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b562"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"axial binding residue","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60344"},{"database":"ChEBI","id":"CHEBI:18248"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"ligand":{"name":"heme b","id":"ChEBI:CHEBI:60344","label":"b566"},"ligandPart":{"name":"Fe","id":"ChEBI:CHEBI:18248"}},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76064.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76064.1"}]}],"geneLocations":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76064.1"}],"geneEncodingType":"Mitochondrion"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022982"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0249","category":"Biological process","name":"Electron transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022617"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0349","category":"Ligand","name":"Heme"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023004"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0408","category":"Ligand","name":"Iron"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023128"},{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76064.1"}],"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022792"}],"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022660"}],"id":"KW-0679","category":"Biological process","name":"Respiratory chain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00968"}],"id":"KW-0813","category":"Biological process","name":"Transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023075"}],"id":"KW-0830","category":"Ligand","name":"Ubiquinone"}],"references":[{"referenceNumber":1,"citation":{"id":"18271636","citationType":"journal article","authors":["Djong T.H.","Matsui M.","Kuramoto M.","Belabut D.M.","Sen Y.H.","Nishioka M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18271636"},{"database":"DOI","id":"10.2108/zsj.24.1197"}],"title":"Morphological divergence, reproductive isolating mechanism, and molecular phylogenetic relationships among Indonesia, Malaysia, and Japan populations of the Fejervarya limnocharis complex (Anura, Ranidae).","publicationDate":"2007","journal":"Zool. Sci.","firstPage":"1197","lastPage":"1212","volume":"24"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76064.1"}],"value":"Muscle","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF76064.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB296096","properties":[{"key":"ProteinId","value":"BAF76064.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A7M6M4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0046872","properties":[{"key":"GoTerm","value":"F:metal ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0008121","properties":[{"key":"GoTerm","value":"F:quinol-cytochrome-c reductase activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006122","properties":[{"key":"GoTerm","value":"P:mitochondrial electron transport, ubiquinol to cytochrome c"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"CDD","id":"cd00284","properties":[{"key":"EntryName","value":"Cytochrome_b_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.810.10","properties":[{"key":"EntryName","value":"Cytochrome Bc1 Complex, Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005798","properties":[{"key":"EntryName","value":"Cyt_b/b6_C"}]},{"database":"InterPro","id":"IPR005797","properties":[{"key":"EntryName","value":"Cyt_b/b6_N"}]},{"database":"InterPro","id":"IPR027387","properties":[{"key":"EntryName","value":"Cytb/b6-like_sf"}]},{"database":"InterPro","id":"IPR048259","properties":[{"key":"EntryName","value":"Cytochrome_b_N_euk/bac"}]},{"database":"InterPro","id":"IPR016174","properties":[{"key":"EntryName","value":"Di-haem_cyt_TM"}]},{"database":"PANTHER","id":"PTHR19271","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR19271:SF16","properties":[{"key":"EntryName","value":"CYTOCHROME B"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00033","properties":[{"key":"EntryName","value":"Cytochrome_B"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81342","properties":[{"key":"EntryName","value":"Transmembrane di-heme cytochromes"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51003","properties":[{"key":"EntryName","value":"CYTB_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51002","properties":[{"key":"EntryName","value":"CYTB_NTER"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VNNGWRLRNLHANGASFLFICIDLHIGRGLCYGSFLYKETWNTGSILLFLVMATAFMGYVLPWGQMSFWGATVITNLLSAAPYIGNDLVQWIWGGFSVDNATLTRFFSFHFVFPFAIAGASMIHLLFLHQTGSSNPTGLNQNLDKVPFHPYFSYKDLLGFVILIGLLAALSTFAPNLLGDPDNFTPANPLVTPPHI","length":196,"molWeight":21690,"crc64":"17DF02A3649B2703","md5":"BFC271F3FED5E25978D05F7AF6DC090A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":4,"Domain":2,"Binding site":4,"Non-terminal residue":2},"uniParcId":"UPI00015BF9F8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1I3","uniProtkbId":"B0I1I3_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":71,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99753.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99753.1"}],"value":"Chemokine receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99753.1"}],"value":"CXCR4"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99753.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99753.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99753.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277307","properties":[{"key":"ProteinId","value":"BAF99753.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB277315","properties":[{"key":"ProteinId","value":"BAF99761.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1I3","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019957","properties":[{"key":"GoTerm","value":"F:C-C chemokine binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016493","properties":[{"key":"GoTerm","value":"F:C-C chemokine receptor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0060326","properties":[{"key":"GoTerm","value":"P:cell chemotaxis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0022008","properties":[{"key":"GoTerm","value":"P:neurogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050119","properties":[{"key":"EntryName","value":"CCR1-9-like"}]},{"database":"InterPro","id":"IPR001277","properties":[{"key":"EntryName","value":"CXCR4/ACKR2"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR10489:SF594","properties":[{"key":"EntryName","value":"C-X-C CHEMOKINE RECEPTOR TYPE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10489","properties":[{"key":"EntryName","value":"CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00645","properties":[{"key":"EntryName","value":"CXCCHMKINER4"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LLFVFSLPFWSVDAAIGWYFKDFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQGSRKMLAEKIVYAGVWLPAVLLTVPDLVFARVTDVEGYNVCDRVYPLANQLNWTIGFRFLHIMVGLLLPGLIILICYCVIISKLSHSKGHQKRKALKTTVILIVAFFACWLPYYICLTIDTFSLLGIIRLSCQMDNTIHKWIAITEALA","length":210,"molWeight":23794,"crc64":"C7497F50BE3A56B3","md5":"D8E05010201B2791B34ADA4645B434FC"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF7E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1I4","uniProtkbId":"B0I1I4_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99754.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99754.1"}],"value":"Chemokine receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99754.1"}],"value":"CXCR4"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99754.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99754.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99754.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277308","properties":[{"key":"ProteinId","value":"BAF99754.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1I4","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019957","properties":[{"key":"GoTerm","value":"F:C-C chemokine binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016493","properties":[{"key":"GoTerm","value":"F:C-C chemokine receptor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0060326","properties":[{"key":"GoTerm","value":"P:cell chemotaxis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0022008","properties":[{"key":"GoTerm","value":"P:neurogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050119","properties":[{"key":"EntryName","value":"CCR1-9-like"}]},{"database":"InterPro","id":"IPR001277","properties":[{"key":"EntryName","value":"CXCR4/ACKR2"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR10489:SF594","properties":[{"key":"EntryName","value":"C-X-C CHEMOKINE RECEPTOR TYPE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10489","properties":[{"key":"EntryName","value":"CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00645","properties":[{"key":"EntryName","value":"CXCCHMKINER4"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"VADLLFVFSLPFWSVDAAIGWYFKDFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQGSRKMLAEKIVYAGVWLPAVLLTVPDLVFARVTDVEGYNVCDRVYPLANQLNWTIGFRFLHIMVGLLLPGLIILICYCVIISKLSHSKGHQKRKALKTTVILIVAFFACWLPYYICLTIDTFSLLGIIRLSCQMDNT","length":201,"molWeight":22731,"crc64":"605004E0F23C1F60","md5":"66B1B3E83D039D084FAA25485121130B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF7F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1I5","uniProtkbId":"B0I1I5_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-03-18","entryVersion":71,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99755.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99755.1"}],"value":"Chemokine receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99755.1"}],"value":"CXCR4"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99755.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99755.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99755.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277309","properties":[{"key":"ProteinId","value":"BAF99755.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB277311","properties":[{"key":"ProteinId","value":"BAF99757.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1I5","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019957","properties":[{"key":"GoTerm","value":"F:C-C chemokine binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016493","properties":[{"key":"GoTerm","value":"F:C-C chemokine receptor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0060326","properties":[{"key":"GoTerm","value":"P:cell chemotaxis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0022008","properties":[{"key":"GoTerm","value":"P:neurogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050119","properties":[{"key":"EntryName","value":"CCR1-9-like"}]},{"database":"InterPro","id":"IPR001277","properties":[{"key":"EntryName","value":"CXCR4/ACKR2"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR10489:SF594","properties":[{"key":"EntryName","value":"C-X-C CHEMOKINE RECEPTOR TYPE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10489","properties":[{"key":"EntryName","value":"CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00645","properties":[{"key":"EntryName","value":"CXCCHMKINER4"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"IRLHLSVADLLFVFSLPFWSVDAAIGWYFKDFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQGSRKMLAEKIVYAGVWLPAVLLTVPDLVFARVTDVEGYNVCDRVYPLANQLNWTIGFRFLHIMVGLLLPGLIILICYCVIISKLSHSKGHQKRKALKTTVILIVAFFACWLPYYICLTIDTFSLLGIIRLSCQMDNTIHKWIAITEALAYFH","length":222,"molWeight":25246,"crc64":"35305C3EEDD88113","md5":"BC21BAFF587E042CAB1BAF116B980962"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF80"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1I6","uniProtkbId":"B0I1I6_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99756.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99756.1"}],"value":"Chemokine receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99756.1"}],"value":"CXCR4"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99756.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99756.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99756.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277310","properties":[{"key":"ProteinId","value":"BAF99756.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1I6","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019957","properties":[{"key":"GoTerm","value":"F:C-C chemokine binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016493","properties":[{"key":"GoTerm","value":"F:C-C chemokine receptor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0060326","properties":[{"key":"GoTerm","value":"P:cell chemotaxis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0022008","properties":[{"key":"GoTerm","value":"P:neurogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050119","properties":[{"key":"EntryName","value":"CCR1-9-like"}]},{"database":"InterPro","id":"IPR001277","properties":[{"key":"EntryName","value":"CXCR4/ACKR2"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR10489:SF594","properties":[{"key":"EntryName","value":"C-X-C CHEMOKINE RECEPTOR TYPE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10489","properties":[{"key":"EntryName","value":"CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00645","properties":[{"key":"EntryName","value":"CXCCHMKINER4"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"YRLHLSVADLLFVFSLPFWSVDAAIGWYFKDFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQGSRKMLAEKIVYAGVWLPAVLLTVPDLVFARVTDVEGYNVCDRVYPLANQLNWTIGFRFLHIMVGLLLPGLIILICYCVIISKLSHSKGHQKRKALKTTVILIVAFFACWLPYYICLTIDTFSLLGIIRLSCQMDNTIHKWIAITEALA","length":219,"molWeight":24849,"crc64":"A50C628BA2D02A81","md5":"40B7C855AF7C3595C24757A9FDBD9790"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF81"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1I8","uniProtkbId":"B0I1I8_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99758.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99758.1"}],"value":"Chemokine receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99758.1"}],"value":"CXCR4"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99758.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99758.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99758.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277312","properties":[{"key":"ProteinId","value":"BAF99758.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1I8","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019957","properties":[{"key":"GoTerm","value":"F:C-C chemokine binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016493","properties":[{"key":"GoTerm","value":"F:C-C chemokine receptor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0060326","properties":[{"key":"GoTerm","value":"P:cell chemotaxis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0022008","properties":[{"key":"GoTerm","value":"P:neurogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050119","properties":[{"key":"EntryName","value":"CCR1-9-like"}]},{"database":"InterPro","id":"IPR001277","properties":[{"key":"EntryName","value":"CXCR4/ACKR2"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR10489:SF594","properties":[{"key":"EntryName","value":"C-X-C CHEMOKINE RECEPTOR TYPE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10489","properties":[{"key":"EntryName","value":"CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00645","properties":[{"key":"EntryName","value":"CXCCHMKINER4"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"LLFVFSLPFWSVDAAIGWYFKDFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQGSRKMLAEKIVYAGVWLPAILLTVPDLVFASVTNIEGYYVCDRIYPLENRLNWTIGFRFLHIMVGLVLPGLIILICYCVIISKLSHSKGHQKRKALKTTVILIVAFFACWLPYYICLTIDTFGLLGIIKLDCQMDNTIHKWIAITEALAYFH","length":213,"molWeight":24304,"crc64":"7C4349A309B076A4","md5":"67F99A5477D9B481E19949EF702E35A1"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF82"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1I9","uniProtkbId":"B0I1I9_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-11-04","lastSequenceUpdateDate":"2008-03-18","entryVersion":65,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99759.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99759.1"}],"value":"Chemokine receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99759.1"}],"value":"CXCR4"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99759.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99759.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99759.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277313","properties":[{"key":"ProteinId","value":"BAF99759.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1I9","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019957","properties":[{"key":"GoTerm","value":"F:C-C chemokine binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016493","properties":[{"key":"GoTerm","value":"F:C-C chemokine receptor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0060326","properties":[{"key":"GoTerm","value":"P:cell chemotaxis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0022008","properties":[{"key":"GoTerm","value":"P:neurogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050119","properties":[{"key":"EntryName","value":"CCR1-9-like"}]},{"database":"InterPro","id":"IPR001277","properties":[{"key":"EntryName","value":"CXCR4/ACKR2"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR10489:SF594","properties":[{"key":"EntryName","value":"C-X-C CHEMOKINE RECEPTOR TYPE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10489","properties":[{"key":"EntryName","value":"CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00645","properties":[{"key":"EntryName","value":"CXCCHMKINER4"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"RMHLSVADLLFVFSLPFWSVDAAIGWYFKDFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQGSRKMLAEKIVYAGVWLPAILLTVPDLVFASVTNIEGYYVCDRIYPLENRLNWTIGFRFLHIMVGLVLPGLIILICYCVIISKLSHSKGHQKRKALKTTVILIVAFFACWLPYYICLTIDTFGLLGIIKLDCQMDNTIHKWIAITEALAYFH","length":221,"molWeight":25214,"crc64":"2E211B22C592339C","md5":"2F49B482C4C681AF9D8A21320FCDD014"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF83"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1J0","uniProtkbId":"B0I1J0_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":64,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99760.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99760.1"}],"value":"Chemokine receptor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99760.1"}],"value":"CXCR4"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004236"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Transmembrane","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"G-protein coupled receptors family 1 profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50262"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99760.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99760.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022475"}],"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023040"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023170"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023224"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00521"}],"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU000688"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99760.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277314","properties":[{"key":"ProteinId","value":"BAF99760.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1J0","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019957","properties":[{"key":"GoTerm","value":"F:C-C chemokine binding"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0016493","properties":[{"key":"GoTerm","value":"F:C-C chemokine receptor activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0019722","properties":[{"key":"GoTerm","value":"P:calcium-mediated signaling"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0060326","properties":[{"key":"GoTerm","value":"P:cell chemotaxis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0022008","properties":[{"key":"GoTerm","value":"P:neurogenesis"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007204","properties":[{"key":"GoTerm","value":"P:positive regulation of cytosolic calcium ion concentration"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050119","properties":[{"key":"EntryName","value":"CCR1-9-like"}]},{"database":"InterPro","id":"IPR001277","properties":[{"key":"EntryName","value":"CXCR4/ACKR2"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"PANTHER","id":"PTHR10489:SF594","properties":[{"key":"EntryName","value":"C-X-C CHEMOKINE RECEPTOR TYPE 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10489","properties":[{"key":"EntryName","value":"CELL ADHESION MOLECULE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00645","properties":[{"key":"EntryName","value":"CXCCHMKINER4"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"SVADLLFVFSLPFWSVDAAIGWYFKDFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQGSRKMLAEKIVYAGVWLPAILLTVPDLVFASVTNIEGYYVCDRIYPLENRLNWTIGFRFLHIMVGLVLPGLIILICYCVIISKLSHSKGHQKRKALKTTVILIVAFFACWLPYYICLTIDTFGLLGIIKLDCQMDNTIHKWIAITEALAYFH","length":217,"molWeight":24676,"crc64":"FA78046468DBBB69","md5":"5DDA2FC8AAA6FC8E8BA55A4190C3BF4D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Transmembrane":4,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF84"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B0I1J7","uniProtkbId":"B0I1J7_FEJLI","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-03-18","entryVersion":50,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Fejervarya limnocharis","commonName":"Paddy field frog","synonyms":["Rana limnocharis"],"taxonId":110108,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99767.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Neobatrachia","Ranoidea","Dicroglossidae","Dicroglossinae","Fejervarya"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99767.1"}],"value":"Na/Ca exchanger"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99767.1"}],"value":"NCX1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004127"}],"value":"Endomembrane system","id":"SL-0147"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004127"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50076"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99767.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99767.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022449"}],"id":"KW-0050","category":"Biological process","name":"Antiport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022568"}],"id":"KW-0109","category":"Biological process","name":"Calcium transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023065"}],"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"18459820","citationType":"journal article","authors":["Kotaki M.","Kurabayashi A.","Matsui M.","Khonsue W.","Djong T.H.","Tandon M.","Sumida M."],"citationCrossReferences":[{"database":"PubMed","id":"18459820"},{"database":"DOI","id":"10.2108/zsj.25.381"}],"title":"Genetic divergences and phylogenetic relationships among the Fejervarya limnocharis complex in Thailand and neighboring countries revealed by mitochondrial and nuclear genes.","publicationDate":"2008","journal":"Zool. Sci.","firstPage":"381","lastPage":"390","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAF99767.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB277321","properties":[{"key":"ProteinId","value":"BAF99767.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB277322","properties":[{"key":"ProteinId","value":"BAF99768.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"B0I1J7","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0098794","properties":[{"key":"GoTerm","value":"C:postsynapse"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0042383","properties":[{"key":"GoTerm","value":"C:sarcolemma"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0005432","properties":[{"key":"GoTerm","value":"F:calcium:sodium antiporter activity"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0098703","properties":[{"key":"GoTerm","value":"P:calcium ion import across plasma membrane"},{"key":"GoEvidenceType","value":"IEA:TreeGrafter"}]},{"database":"GO","id":"GO:0007154","properties":[{"key":"GoTerm","value":"P:cell communication"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"2.60.40.2030","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1420.30","properties":[{"key":"EntryName","value":"NCX, central ion-binding region"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR051171","properties":[{"key":"EntryName","value":"CaCA"}]},{"database":"InterPro","id":"IPR038081","properties":[{"key":"EntryName","value":"CalX-like_sf"}]},{"database":"InterPro","id":"IPR003644","properties":[{"key":"EntryName","value":"Calx_beta"}]},{"database":"InterPro","id":"IPR001623","properties":[{"key":"EntryName","value":"DnaJ_domain"}]},{"database":"InterPro","id":"IPR032452","properties":[{"key":"EntryName","value":"Na_Ca_Ex_C-exten"}]},{"database":"InterPro","id":"IPR004837","properties":[{"key":"EntryName","value":"NaCa_Exmemb"}]},{"database":"InterPro","id":"IPR044880","properties":[{"key":"EntryName","value":"NCX_ion-bd_dom_sf"}]},{"database":"PANTHER","id":"PTHR11878","properties":[{"key":"EntryName","value":"SODIUM/CALCIUM EXCHANGER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11878:SF6","properties":[{"key":"EntryName","value":"SODIUM_CALCIUM EXCHANGER 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03160","properties":[{"key":"EntryName","value":"Calx-beta"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01699","properties":[{"key":"EntryName","value":"Na_Ca_ex"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16494","properties":[{"key":"EntryName","value":"Na_Ca_ex_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00237","properties":[{"key":"EntryName","value":"Calx_beta"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF141072","properties":[{"key":"EntryName","value":"CalX-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50076","properties":[{"key":"EntryName","value":"DNAJ_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"GDLGPSTIVGSAAFNMFIIIALCVYVVPDGEIRKIKHLRVFFVTAAWSIFAYTWLYMILSVFSPGVVEVWESLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPSSKADIEMDGKVLNSHTENFLDGSLVLEVDEKDQDDEEARRDMARILKELKQKHPEKEMEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNNEAVENDPVSKIYFEQANYQCLENCGTVALTIVRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGLLYST","length":304,"molWeight":34715,"crc64":"98C0000620C81EA1","md5":"E0B4774694C36BB48685D9540250D8BB"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":3,"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000163DF6C"}}]}