{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9BQA1","secondaryAccessions":["B3KMW6","B4DP38","Q3LID2","Q53FU2","Q6JZZ5","Q96GK4","Q9BWY3"],"uniProtkbId":"MEP50_HUMAN","entryAudit":{"firstPublicDate":"2003-06-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":205,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Methylosome protein WDR77"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17437848"}],"value":"Androgen receptor cofactor p44"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:29652"}],"value":"Methylosome protein 50"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"MEP-50"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:29652"}],"value":"WD repeat-containing protein 77"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12972618"}],"value":"p44/Mep50"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:29652"}],"value":"WDR77"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:29652"}],"value":"MEP50"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18984161"}],"value":"WD45"}],"orfNames":[{"value":"HKMT1069"},{"value":"Nbla10071"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11756452"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"}],"value":"Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11756452"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12560496"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12972618"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16087681"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16712789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18984161"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19188445"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21081503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25284789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27337956"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33376131"}],"value":"Component of the methylosome complex composed of PRMT5, WDR77 and CLNS1A (PubMed:18984161, PubMed:21081503). Found in a complex composed of PRMT5, WDR77 and RIOK1 (PubMed:21081503). RIOK1 and CLNS1A bound directly to PRMT5 at the same binding site, in a mutually exclusive manner, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively (PubMed:21081503). Found in a complex with the component of the methylosome, PRMT5, CLNS1A, WDR77, PRMT1 and ERH (PubMed:25284789). Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE (PubMed:11756452, PubMed:33376131). Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts with SUZ12 and histone H2A/H2AC20, but not with histones H2B, H3 nor H4 (PubMed:16712789). Interacts with CTDP1 and LSM11 (PubMed:12560496, PubMed:16087681). Interacts with APEX1, AR and NKX3-1 (PubMed:12972618, PubMed:19188445). Interacts with CHTOP (PubMed:25284789). Interacts with FAM47E. Interacts with TSC22D2 (PubMed:27337956)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BQA1","intActId":"EBI-1237307"},"interactantTwo":{"uniProtKBAccession":"P55212","geneName":"CASP6","intActId":"EBI-718729"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA1","intActId":"EBI-1237307"},"interactantTwo":{"uniProtKBAccession":"P04792","geneName":"HSPB1","intActId":"EBI-352682"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA1","intActId":"EBI-1237307"},"interactantTwo":{"uniProtKBAccession":"O60333-2","geneName":"KIF1B","intActId":"EBI-10975473"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA1","intActId":"EBI-1237307"},"interactantTwo":{"uniProtKBAccession":"P13473-2","geneName":"LAMP2","intActId":"EBI-21591415"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA1","intActId":"EBI-1237307"},"interactantTwo":{"uniProtKBAccession":"O14744","geneName":"PRMT5","intActId":"EBI-351098"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA1","intActId":"EBI-1237307"},"interactantTwo":{"uniProtKBAccession":"P62826","geneName":"RAN","intActId":"EBI-286642"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA1","intActId":"EBI-1237307"},"interactantTwo":{"uniProtKBAccession":"Q9Y3C5","geneName":"RNF11","intActId":"EBI-396669"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA1","intActId":"EBI-1237307"},"interactantTwo":{"uniProtKBAccession":"O76024","geneName":"WFS1","intActId":"EBI-720609"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA1","intActId":"EBI-1237307"},"interactantTwo":{"uniProtKBAccession":"P03418","geneName":"N","intActId":"EBI-6930799"},"numberOfExperiments":3,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17437848"}],"value":"Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors (PubMed:17437848)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17437848"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21081503"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17437848"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21081503"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27337956"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9BQA1-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9BQA1-2"],"sequenceIds":["VSP_056166"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12972618"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17437848"}],"value":"Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17437848"}],"value":"Expressed in Leydig cells during fetal testicular development, especially during the second semester. Germ cells expression is detected as early as 10 weeks of gestation"}],"commentType":"DEVELOPMENTAL STAGE"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/44142/WDR77","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"Methylosome protein WDR77","featureId":"PRO_0000051074"},{"type":"Repeat","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"}]},{"type":"Repeat","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"}]},{"type":"Repeat","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"}]},{"type":"Repeat","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"}]},{"type":"Repeat","location":{"start":{"value":209,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"}]},{"type":"Repeat","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"}]},{"type":"Repeat","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"WD 7","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23071334"}]},{"type":"Modified residue","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.8"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Alternative sequence","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_056166","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"in dbSNP:rs7416672","featureCrossReferences":[{"database":"dbSNP","id":"rs7416672"}],"featureId":"VAR_042903","alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in Ref. 2; BAD96909","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"in Ref. 7; AAH09411","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"LTTVGWDHQVVHHVVPTEPLPAPGPASVTE","alternativeSequences":["DLQVLLSRLDLRQKASPP"]}},{"type":"Beta strand","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7BO7"}]},{"type":"Helix","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZVL"}]},{"type":"Beta strand","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S1P"}]},{"type":"Beta strand","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Helix","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Helix","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Turn","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V0P"}]},{"type":"Beta strand","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGR"}]},{"type":"Beta strand","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VEX"}]},{"type":"Beta strand","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Turn","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9E3A"}]},{"type":"Beta strand","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Turn","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EYV"}]},{"type":"Beta strand","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VEY"}]},{"type":"Helix","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VEU"}]},{"type":"Beta strand","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Turn","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7S0U"}]},{"type":"Beta strand","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Turn","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8VEX"}]},{"type":"Beta strand","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGR"}]},{"type":"Beta strand","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Beta strand","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6V0P"}]},{"type":"Beta strand","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]},{"type":"Turn","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8CSG"}]},{"type":"Beta strand","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9MGQ"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11756452","citationType":"journal article","authors":["Friesen W.J.","Wyce A.","Paushkin S.","Abel L.","Rappsilber J.","Mann M.","Dreyfuss G."],"citationCrossReferences":[{"database":"PubMed","id":"11756452"},{"database":"DOI","id":"10.1074/jbc.m109984200"}],"title":"A novel WD repeat protein component of the methylosome binds Sm proteins.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"8243","lastPage":"8247","volume":"277"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","PROTEIN SEQUENCE OF 4-15; 38-52; 122-145; 151-164 AND 192-198","FUNCTION","INTERACTION WITH PRMT5; SNRPB; SNRPD2; SNRPD3 AND SNRPE","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":2,"citation":{"id":"12972618","citationType":"journal article","authors":["Hosohata K.","Li P.","Hosohata Y.","Qin J.","Roeder R.G.","Wang Z."],"citationCrossReferences":[{"database":"PubMed","id":"12972618"},{"database":"DOI","id":"10.1128/mcb.23.19.7019-7029.2003"}],"title":"Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"7019","lastPage":"7029","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","PROTEIN SEQUENCE OF 3-15","TISSUE SPECIFICITY","INTERACTION WITH AR AND NKX3-1"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Kidney proximal tubule","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15221005","citationType":"journal article","authors":["Yamada S.","Ohira M.","Horie H.","Ando K.","Takayasu H.","Suzuki Y.","Sugano S.","Hirata T.","Goto T.","Matsunaga T.","Hiyama E.","Hayashi Y.","Ando H.","Suita S.","Kaneko M.","Sasaki F.","Hashizume K.","Ohnuma N.","Nakagawara A."],"citationCrossReferences":[{"database":"PubMed","id":"15221005"},{"database":"DOI","id":"10.1038/sj.onc.1207782"}],"title":"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.","publicationDate":"2004","journal":"Oncogene","firstPage":"5901","lastPage":"5911","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Hepatoblastoma","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Colon","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"CI-43JDV6VDN1JOO","citationType":"submission","authors":["Bienvenut W.V.","Zebisch A.","Kolch W."],"publicationDate":"DEC-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 3-15; 36-52; 122-145; 151-179 AND 192-198","PHOSPHORYLATION AT THR-5","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Colon carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"12880961","citationType":"journal article","authors":["Ohira M.","Morohashi A.","Nakamura Y.","Isogai E.","Furuya K.","Hamano S.","Machida T.","Aoyama M.","Fukumura M.","Miyazaki K.","Suzuki Y.","Sugano S.","Hirato J.","Nakagawara A."],"citationCrossReferences":[{"database":"PubMed","id":"12880961"},{"database":"DOI","id":"10.1016/s0304-3835(03)00085-5"}],"title":"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.","publicationDate":"2003","journal":"Cancer Lett.","firstPage":"63","lastPage":"68","volume":"197"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 184-342 (ISOFORM 1)"],"referenceComments":[{"value":"Neuroblastoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"12560496","citationType":"journal article","authors":["Licciardo P.","Amente S.","Ruggiero L.","Monti M.","Pucci P.","Lania L.","Majello B."],"citationCrossReferences":[{"database":"PubMed","id":"12560496"},{"database":"DOI","id":"10.1093/nar/gkg197"}],"title":"The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP.","publicationDate":"2003","journal":"Nucleic Acids Res.","firstPage":"999","lastPage":"1005","volume":"31"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH CTDP1"]},{"referenceNumber":11,"citation":{"id":"16087681","citationType":"journal article","authors":["Azzouz T.N.","Pillai R.S.","Dapp C.","Chari A.","Meister G.","Kambach C.","Fischer U.","Schuemperli D."],"citationCrossReferences":[{"database":"PubMed","id":"16087681"},{"database":"DOI","id":"10.1074/jbc.m505077200"}],"title":"Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"34435","lastPage":"34440","volume":"280"},"referencePositions":["INTERACTION WITH LSM11"]},{"referenceNumber":12,"citation":{"id":"16712789","citationType":"journal article","authors":["Furuno K.","Masatsugu T.","Sonoda M.","Sasazuki T.","Yamamoto K."],"citationCrossReferences":[{"database":"PubMed","id":"16712789"},{"database":"DOI","id":"10.1016/j.bbrc.2006.05.014"}],"title":"Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro.","publicationDate":"2006","journal":"Biochem. Biophys. Res. Commun.","firstPage":"1051","lastPage":"1058","volume":"345"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH H2AC20; PRMT5 AND SUZ12"]},{"referenceNumber":13,"citation":{"id":"17437848","citationType":"journal article","authors":["Liang J.J.","Wang Z.","Chiriboga L.","Greco M.A.","Shapiro E.","Huang H.","Yang X.J.","Huang J.","Peng Y.","Melamed J.","Garabedian M.J.","Lee P."],"citationCrossReferences":[{"database":"PubMed","id":"17437848"},{"database":"DOI","id":"10.1016/j.juro.2007.01.017"}],"title":"The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors.","publicationDate":"2007","journal":"J. Urol.","firstPage":"1918","lastPage":"1922","volume":"177"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"]},{"referenceNumber":14,"citation":{"id":"18984161","citationType":"journal article","authors":["Chari A.","Golas M.M.","Klingenhager M.","Neuenkirchen N.","Sander B.","Englbrecht C.","Sickmann A.","Stark H.","Fischer U."],"citationCrossReferences":[{"database":"PubMed","id":"18984161"},{"database":"DOI","id":"10.1016/j.cell.2008.09.020"}],"title":"An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.","publicationDate":"2008","journal":"Cell","firstPage":"497","lastPage":"509","volume":"135"},"referencePositions":["IDENTIFICATION IN THE METHYLOSOME COMPLEX"]},{"referenceNumber":15,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"19188445","citationType":"journal article","authors":["Vascotto C.","Fantini D.","Romanello M.","Cesaratto L.","Deganuto M.","Leonardi A.","Radicella J.P.","Kelley M.R.","D'Ambrosio C.","Scaloni A.","Quadrifoglio F.","Tell G."],"citationCrossReferences":[{"database":"PubMed","id":"19188445"},{"database":"DOI","id":"10.1128/mcb.01337-08"}],"title":"APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.","publicationDate":"2009","journal":"Mol. Cell. Biol.","firstPage":"1834","lastPage":"1854","volume":"29"},"referencePositions":["INTERACTION WITH APEX1","IDENTIFICATION BY MASS SPECTROMETRY","SUBCELLULAR LOCATION"]},{"referenceNumber":17,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"21081503","citationType":"journal article","authors":["Guderian G.","Peter C.","Wiesner J.","Sickmann A.","Schulze-Osthoff K.","Fischer U.","Grimmler M."],"citationCrossReferences":[{"database":"PubMed","id":"21081503"},{"database":"DOI","id":"10.1074/jbc.m110.148486"}],"title":"RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.","publicationDate":"2011","journal":"J. Biol. Chem.","firstPage":"1976","lastPage":"1986","volume":"286"},"referencePositions":["SUBUNIT","SUBCELLULAR LOCATION","IDENTIFICATION IN A COMPLEX WITH PRTM5; WDR77; RIOK1 OR CLNS1A"]},{"referenceNumber":21,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":22,"citation":{"id":"25284789","citationType":"journal article","authors":["Takai H.","Masuda K.","Sato T.","Sakaguchi Y.","Suzuki T.","Suzuki T.","Koyama-Nasu R.","Nasu-Nishimura Y.","Katou Y.","Ogawa H.","Morishita Y.","Kozuka-Hata H.","Oyama M.","Todo T.","Ino Y.","Mukasa A.","Saito N.","Toyoshima C.","Shirahige K.","Akiyama T."],"citationCrossReferences":[{"database":"PubMed","id":"25284789"},{"database":"DOI","id":"10.1016/j.celrep.2014.08.071"}],"title":"5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.","publicationDate":"2014","journal":"Cell Rep.","firstPage":"48","lastPage":"60","volume":"9"},"referencePositions":["INTERACTION WITH CHTOP","IDENTIFICATION IN THE METHYLOSOME COMPLEX WITH PRMT1; PRMT5 AND ERH"]},{"referenceNumber":23,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"27337956","citationType":"journal article","authors":["Li Q.","Chen P.","Zeng Z.","Liang F.","Song Y.","Xiong F.","Li X.","Gong Z.","Zhou M.","Xiang B.","Peng C.","Li X.","Chen X.","Li G.","Xiong W."],"citationCrossReferences":[{"database":"PubMed","id":"27337956"},{"database":"DOI","id":"10.1007/s13277-016-5113-z"}],"title":"Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2.","publicationDate":"2016","journal":"Tumor Biol.","firstPage":"12503","lastPage":"12512","volume":"37"},"referencePositions":["INTERACTION WITH TSC22D2","SUBCELLULAR LOCATION"]},{"referenceNumber":25,"citation":{"id":"33376131","citationType":"journal article","authors":["Chakrapani B.","Khan M.I.K.","Kadumuri R.V.","Gupta S.","Verma M.","Awasthi S.","Govindaraju G.","Mahesh A.","Rajavelu A.","Chavali S.","Dhayalan A."],"citationCrossReferences":[{"database":"PubMed","id":"33376131"},{"database":"DOI","id":"10.26508/lsa.202000699"}],"title":"The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions.","publicationDate":"2021","journal":"Life. Sci Alliance","firstPage":"e202000699","lastPage":"e202000699","volume":"4"},"referencePositions":["INTERACTION WITH PRMT5"]},{"referenceNumber":26,"citation":{"id":"23071334","citationType":"journal article","authors":["Antonysamy S.","Bonday Z.","Campbell R.M.","Doyle B.","Druzina Z.","Gheyi T.","Han B.","Jungheim L.N.","Qian Y.","Rauch C.","Russell M.","Sauder J.M.","Wasserman S.R.","Weichert K.","Willard F.S.","Zhang A.","Emtage S."],"citationCrossReferences":[{"database":"PubMed","id":"23071334"},{"database":"DOI","id":"10.1073/pnas.1209814109"}],"title":"Crystal structure of the human PRMT5:MEP50 complex.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"17960","lastPage":"17965","volume":"109"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.06 ANGSTROMS) OF 2-342 IN COMPLEX WITH PRMT5","FUNCTION","WD REPEATS","SUBUNIT"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF478464","properties":[{"key":"ProteinId","value":"AAL79917.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK022860","properties":[{"key":"ProteinId","value":"BAG51128.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK298179","properties":[{"key":"ProteinId","value":"BAG60450.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK223189","properties":[{"key":"ProteinId","value":"BAD96909.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY225316","properties":[{"key":"ProteinId","value":"AAP79114.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB073603","properties":[{"key":"ProteinId","value":"BAD38641.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL390195","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471122","properties":[{"key":"ProteinId","value":"EAW56493.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC001679","properties":[{"key":"ProteinId","value":"AAH01679.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC006477","properties":[{"key":"ProteinId","value":"AAH06477.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC009411","properties":[{"key":"ProteinId","value":"AAH09411.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC011778","properties":[{"key":"ProteinId","value":"AAH11778.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC016946","properties":[{"key":"ProteinId","value":"AAH16946.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB074171","properties":[{"key":"ProteinId","value":"BAE45736.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS835.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BQA1-1"},{"database":"RefSeq","id":"NP_001303991.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001317062.2"}]},{"database":"RefSeq","id":"NP_001303992.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001317063.2"}]},{"database":"RefSeq","id":"NP_001303993.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001317064.2"}],"isoformId":"Q9BQA1-2"},{"database":"RefSeq","id":"NP_077007.1","properties":[{"key":"NucleotideSequenceId","value":"NM_024102.4"}],"isoformId":"Q9BQA1-1"},{"database":"PDB","id":"4GQB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.06 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"4X60","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"4X61","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"4X63","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"5C9Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.36 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"5EMJ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.27 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"5EMK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.52 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"5EML","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.39 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"5EMM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.37 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"5FA5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.34 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6CKC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6K1S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6RLL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.22 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6RLQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.53 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6UGH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6UXX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.69 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6UXY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.57 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6V0N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.11 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6V0O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.86 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"6V0P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.88 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7BO7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.83 A"},{"key":"Chains","value":"BBB=2-342"}]},{"database":"PDB","id":"7KIB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.52 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7KIC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.43 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7KID","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7L1G","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.47 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7M05","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.39 A"},{"key":"Chains","value":"B/D/F/H=2-342"}]},{"database":"PDB","id":"7MX7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.49 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7MXA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.71 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7MXC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.41 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7MXG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D=2-342"}]},{"database":"PDB","id":"7MXN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.55 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7S0U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7S1P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.21 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7S1Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.78 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7S1R","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7S1S","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.62 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7SER","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.14 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7SES","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7U30","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"B=18-342"}]},{"database":"PDB","id":"7UOH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7UY1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.66 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7UYF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.82 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7ZUP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7ZUQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.48 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7ZUU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7ZUY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7ZV2","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.01 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7ZVL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.39 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"7ZVU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.95 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"8CSG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.48 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"8CTB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.61 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"8CYI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.14 A"},{"key":"Chains","value":"B=21-329"}]},{"database":"PDB","id":"8G1U","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.83 A"},{"key":"Chains","value":"B/F/J/N=1-342"}]},{"database":"PDB","id":"8VEO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"8VET","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.63 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"8VEU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.46 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"8VEW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.69 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"8VEX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.79 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"8VEY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.44 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"8X6L","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.16 A"},{"key":"Chains","value":"B/D/G/H=1-342"}]},{"database":"PDB","id":"9C10","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9DOD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9E3A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.36 A"},{"key":"Chains","value":"K=1-342"}]},{"database":"PDB","id":"9E3B","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.06 A"},{"key":"Chains","value":"B/E/H/K=1-342"}]},{"database":"PDB","id":"9EYU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"B=1-342"}]},{"database":"PDB","id":"9EYV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"B=1-342"}]},{"database":"PDB","id":"9EYW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"B=1-342"}]},{"database":"PDB","id":"9EYX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B=1-342"}]},{"database":"PDB","id":"9MGL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9MGM","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9MGN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.82 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9MGP","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.67 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9MGQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9MGR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.07 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9MRE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9N3N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.75 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9N3O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.37 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9N3P","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.51 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9N3Q","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.54 A"},{"key":"Chains","value":"B/D=2-342"}]},{"database":"PDB","id":"9N3R","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.47 A"},{"key":"Chains","value":"B/D=2-342"}]},{"database":"PDB","id":"9NWY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9PCA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9PXZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.47 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9PY0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.36 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDB","id":"9PY1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.04 A"},{"key":"Chains","value":"B=2-342"}]},{"database":"PDBsum","id":"4GQB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4X60","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4X61","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4X63","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5C9Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5EMJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5EMK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5EML","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5EMM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5FA5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CKC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6K1S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RLL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6RLQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6UGH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6UXX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6UXY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V0N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V0O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6V0P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7BO7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KIB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KIC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KID","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7L1G","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7M05","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MX7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MXA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MXC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MXG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7MXN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7S0U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7S1P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7S1Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7S1R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7S1S","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SER","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7SES","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7U30","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UOH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UY1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UYF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZUP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZUQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZUU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZUY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZV2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZVL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZVU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CSG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CTB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8CYI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8G1U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VEO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VET","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VEU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VEW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VEX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VEY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8X6L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9C10","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9DOD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E3A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9E3B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EYU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EYV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EYW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EYX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MGL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MGM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MGN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MGP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MGQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MGR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MRE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9N3N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9N3O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9N3P","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9N3Q","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9N3R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9NWY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9PCA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9PXZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9PY0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9PY1","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-20764","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23609","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27078","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-29677","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38091","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47476","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-47477","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-7137","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"122532","properties":[{"key":"Interactions","value":"396"}]},{"database":"ComplexPortal","id":"CPX-696","properties":[{"key":"EntryName","value":"PRMT5 methylosome complex, CLNS1A variant"}]},{"database":"ComplexPortal","id":"CPX-8148","properties":[{"key":"EntryName","value":"PRMT5 methylosome complex, RIOK1 variant"}]},{"database":"ComplexPortal","id":"CPX-8149","properties":[{"key":"EntryName","value":"PRMT5 methylosome complex, COPR5 variant"}]},{"database":"CORUM","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-38172N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9BQA1","properties":[{"key":"Number of interactors","value":"3688"}]},{"database":"IntAct","id":"Q9BQA1","properties":[{"key":"Interactions","value":"129"}]},{"database":"MINT","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-WDR77","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000235090","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3108649","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9BQA1","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"WDR77","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"32171507","properties":[{"key":"Description","value":"-"}]},{"database":"REPRODUCTION-2DPAGE","id":"IPI00012202","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000235090","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"4753","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"78647","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BQA1-1"},{"database":"Pumba","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"35257","properties":[{"key":"antibodies","value":"301 antibodies from 36 providers"}]},{"database":"DNASU","id":"79084","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000235090.10","properties":[{"key":"ProteinId","value":"ENSP00000235090.5"},{"key":"GeneId","value":"ENSG00000116455.14"}],"isoformId":"Q9BQA1-1"},{"database":"GeneID","id":"79084","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:79084","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000235090.10","properties":[{"key":"ProteinId","value":"ENSP00000235090.5"},{"key":"RefSeqNucleotideId","value":"NM_024102.4"},{"key":"RefSeqProteinId","value":"NP_077007.1"}]},{"database":"UCSC","id":"uc001ebb.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9BQA1-1"},{"database":"AGR","id":"HGNC:29652","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142670581","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79084","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"79084","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"WDR77","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:29652","properties":[{"key":"GeneName","value":"WDR77"}]},{"database":"HPA","id":"ENSG00000116455","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (fallopian)"}]},{"database":"MIM","id":"611734","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000116455","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000116455","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0284","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000010711","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_051285_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QMGCNAS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10260946at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9BQA1","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-191859","properties":[{"key":"PathwayName","value":"snRNP Assembly"}]},{"database":"Reactome","id":"R-HSA-3214858","properties":[{"key":"PathwayName","value":"RMTs methylate histone arginines"}]},{"database":"SignaLink","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000116455","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"79084","properties":[{"key":"hits","value":"770 hits in 1169 CRISPR screens"}]},{"database":"CD-CODE","id":"232F8A39","properties":[{"key":"EntryName","value":"P-body"}]},{"database":"ChiTaRS","id":"WDR77","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"WD_repeat-containing_protein_77","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"79084","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9BQA1","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9BQA1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q9BQA1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000116455","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 202 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9BQA1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031465","properties":[{"key":"GoTerm","value":"C:Cul4B-RING E3 ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19188445"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27337956"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18984161"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21081503"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0034709","properties":[{"key":"GoTerm","value":"C:methylosome"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18984161"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25284789"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21081503"}]},{"database":"GO","id":"GO:0008327","properties":[{"key":"GoTerm","value":"F:methyl-CpG binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25284789"}]},{"database":"GO","id":"GO:0003713","properties":[{"key":"GoTerm","value":"F:transcription coactivator activity"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"12972618"}]},{"database":"GO","id":"GO:1990756","properties":[{"key":"GoTerm","value":"F:ubiquitin-like ligase-substrate adaptor activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048026","properties":[{"key":"GoTerm","value":"P:positive regulation of mRNA splicing, via spliceosome"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11756452"}]},{"database":"GO","id":"GO:2000234","properties":[{"key":"GoTerm","value":"P:positive regulation of rRNA processing"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20159986"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"33624332"}]},{"database":"GO","id":"GO:0000209","properties":[{"key":"GoTerm","value":"P:protein polyubiquitination"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0000387","properties":[{"key":"GoTerm","value":"P:spliceosomal snRNP assembly"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11756452"}]},{"database":"GO","id":"GO:0006511","properties":[{"key":"GoTerm","value":"P:ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"FunFam","id":"2.130.10.10:FF:000322","properties":[{"key":"EntryName","value":"Methylosome protein 50"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00583","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR052139","properties":[{"key":"EntryName","value":"Methylosome_Comp_WDR77"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"PANTHER","id":"PTHR46853","properties":[{"key":"EntryName","value":"METHYLOSOME PROTEIN 50"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46853:SF3","properties":[{"key":"EntryName","value":"METHYLOSOME PROTEIN WDR77"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE","length":342,"molWeight":36724,"crc64":"3D355AEC68491ECB","md5":"13BF81A1F3AE33811035914B8523735C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":9,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Repeat":7,"Modified residue":1,"Alternative sequence":1,"Natural variant":1,"Sequence conflict":2,"Beta strand":40,"Helix":4,"Turn":6},"uniParcId":"UPI0000047AC6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0Y711","uniProtkbId":"H0Y711_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":78,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000409300.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00040457"}],"value":"Methylosome protein WDR77"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041769"}],"value":"Methylosome protein 50"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00041554"}],"value":"WD repeat-containing protein 77"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000409300.1"}],"value":"WDR77"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00046151"}],"value":"Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00064154"}],"value":"Component of the methylosome complex composed of PRMT5, WDR77 and CLNS1A. Found in a complex composed of PRMT5, WDR77 and RIOK1. RIOK1 and CLNS1A bound directly to PRMT5 at the same binding site, in a mutually exclusive manner, which allows the recruitment of distinct methylation substrates, such as nucleolin/NCL and Sm proteins, respectively. Found in a complex with the component of the methylosome, PRMT5, CLNS1A, WDR77, PRMT1 and ERH. Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE. Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts with SUZ12 and histone H2A/H2AC20, but not with histones H2B, H3 nor H4. Interacts with CTDP1 and LSM11. Interacts with APEX1, AR and NKX3-1. Interacts with CHTOP. Interacts with FAM47E. Interacts with TSC22D2"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Repeat","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Repeat","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"WD","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000409300.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0Y711"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0Y711"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022574"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00221"}],"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000409300.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000409300.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000409300.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000409300.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL390195","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"IntAct","id":"H0Y711","properties":[{"key":"Interactions","value":"1"}]},{"database":"MassIVE","id":"H0Y711","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"35335","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"35257","properties":[{"key":"antibodies","value":"301 antibodies from 36 providers"}]},{"database":"Ensembl","id":"ENST00000449340.1","properties":[{"key":"ProteinId","value":"ENSP00000409300.1"},{"key":"GeneId","value":"ENSG00000116455.14"}]},{"database":"UCSC","id":"uc057jis.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:29652","properties":[{"key":"GeneName","value":"WDR77"}]},{"database":"OpenTargets","id":"ENSG00000116455","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000116455","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000010711","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10260946at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"WDR77","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000116455","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 202 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0Y711","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:1990234","properties":[{"key":"GoTerm","value":"C:transferase complex"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"2.130.10.10:FF:000322","properties":[{"key":"EntryName","value":"Methylosome protein 50"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR052139","properties":[{"key":"EntryName","value":"Methylosome_Comp_WDR77"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"PANTHER","id":"PTHR46853","properties":[{"key":"EntryName","value":"METHYLOSOME PROTEIN 50"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46853:SF3","properties":[{"key":"EntryName","value":"METHYLOSOME PROTEIN WDR77"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"6"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"XCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHRLDLSQPSPPSDSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE","length":291,"molWeight":31099,"crc64":"49734C8C7DE5A4F4","md5":"B7309E80F3FA1D8AD30237E172B80101"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Repeat":2,"Non-terminal residue":1},"uniParcId":"UPI000059D02B"}}]}