{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P61964","secondaryAccessions":["Q91VA5","Q9NWX7","Q9UGP9"],"uniProtkbId":"WDR5_HUMAN","entryAudit":{"firstPublicDate":"2004-06-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-06-07","entryVersion":213,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"WD repeat-containing protein 5"}},"alternativeNames":[{"fullName":{"value":"BMP2-induced 3-kb gene protein"}}]},"genes":[{"geneName":{"value":"WDR5"},"synonyms":[{"value":"BIG3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P61965"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16600877"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829960"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18840606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19103755"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19131338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19556245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20018852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21220120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22266653"}],"value":"Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P61965"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q498M4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12670868"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14992727"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15199122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15960975"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16253997"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16600877"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829959"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16829960"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16946699"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17021013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17355966"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17500065"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17998332"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18378692"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18829459"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18838538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18840606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19103755"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19131338"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19556245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20018852"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21220120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22266653"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22665483"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23178126"}],"value":"Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3 (By similarity). Interacts with HCFC1 (PubMed:12670868). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:19103755). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (PubMed:16253997, PubMed:17355966, PubMed:17998332, PubMed:18838538). Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7 (PubMed:15199122, PubMed:15960975, PubMed:17021013, PubMed:17500065). Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BACC1, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin (PubMed:14992727, PubMed:18378692). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852). Interacts with KMT2A/MLL1 (via WIN motif) and RBBP5; the interaction is direct (PubMed:18829459, PubMed:18840606, PubMed:19556245, PubMed:21220120, PubMed:22266653, PubMed:22665483). Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (PubMed:19103755). In the complex, it probably interacts directly with KAT2A, MBIP and KAT14 (PubMed:19103755). Interacts with histone H3 (PubMed:16600877, PubMed:16829959, PubMed:16829960, PubMed:16946699). Interacts with SETD1A (via WIN motif) (PubMed:17998332, PubMed:22266653, PubMed:22665483). Component of a histone methylation complex composed of at least ZNF335, RBBP5, ASH2L and WDR5; the complex may have histone H3-specific methyltransferase activity, however does not have specificity for 'Lys-4' of histone H3 (PubMed:19131338). Interacts with ZNF335 (PubMed:19131338, PubMed:23178126). Components of this complex may associate with components of the ZNF335-CCAR2-EMSY nuclear receptor-mediated transcription complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (PubMed:19131338). Interacts with PER1 (By similarity). Interacts with KMT2B (via WIN motif), KMT2C (via WIN motif), KMT2D (via WIN motif) and SETD1B (via WIN motif) (PubMed:18840606, PubMed:22266653, PubMed:22665483)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34850113"}],"value":"(Microbial infection) Interacts with herpes virus 8/HHV-8 protein LANA1; this interaction regulates the MLL1 histone methyltransferase activity on viral DNA"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"O43823","geneName":"AKAP8","intActId":"EBI-1237481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q9UJX6","geneName":"ANAPC2","intActId":"EBI-396211"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"P54259","geneName":"ATN1","intActId":"EBI-945980"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q86V38","geneName":"ATN1","intActId":"EBI-11954292"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q96PG8","geneName":"BBC3","intActId":"EBI-17289784"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q8NFC6","geneName":"BOD1L1","intActId":"EBI-2654318"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"A2RRG2","geneName":"C1orf104","intActId":"EBI-10173042"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q9HCK8","geneName":"CHD8","intActId":"EBI-1169146"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q14204","geneName":"DYNC1H1","intActId":"EBI-356015"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q6PEV8","geneName":"FAM199X","intActId":"EBI-4280426"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"P68431","geneName":"H3C12","intActId":"EBI-79722"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"P51610","geneName":"HCFC1","intActId":"EBI-396176"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q03933","geneName":"HSF2","intActId":"EBI-2556750"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q7Z3B3","geneName":"KANSL1","intActId":"EBI-740244"},"numberOfExperiments":15,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q9H9L4","geneName":"KANSL2","intActId":"EBI-2560840"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q92794","geneName":"KAT6A","intActId":"EBI-948013"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"O15550","geneName":"KDM6A","intActId":"EBI-4292203"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q92876","geneName":"KLK6","intActId":"EBI-2432309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q03164","geneName":"KMT2A","intActId":"EBI-591370"},"numberOfExperiments":17,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q03164","geneName":"KMT2A","chainId":"PRO_0000390950","intActId":"EBI-2638616"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q9UMN6","geneName":"KMT2B","intActId":"EBI-765774"},"numberOfExperiments":11,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q8NEZ4","geneName":"KMT2C","intActId":"EBI-1042997"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"O14686","geneName":"KMT2D","intActId":"EBI-996065"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ProtKBAccession":"P61964","intActId":"EBI-540834"},"interactantTwo":{"uniProtKBAccession":"Q9WTL8","geneName":"Bmal1","intActId":"EBI-644534"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR 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