{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O00401","secondaryAccessions":["A1JUI9","Q7Z746"],"uniProtkbId":"WASL_HUMAN","entryAudit":{"firstPublicDate":"2001-04-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-02-01","entryVersion":232,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Actin nucleation-promoting factor WASL"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16767080"}],"value":"Neural Wiskott-Aldrich syndrome protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16767080"}],"value":"N-WASP"}]}]},"genes":[{"geneName":{"value":"WASL"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91YD9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16767080"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19366662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19487689"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19767742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22847007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22921828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9422512"}],"value":"Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91YD9"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q95107"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16234328"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16246732"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16257963"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16767080"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17015620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19487689"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19767742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22847007"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24332715"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29887380"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9422512"}],"value":"Binds actin and the Arp2/3 complex (PubMed:22847007). Interacts with CDC42 (PubMed:9422512, PubMed:16246732). Interacts with FCHSD1 (By similarity). Interacts with FCHSD2 (PubMed:29887380). Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP (PubMed:17015620, PubMed:19767742, PubMed:24332715). Interacts with SNX9 (By similarity). Interacts with the WW domains of PRPF40A/FBP11 (By similarity). Interacts with PTK2/FAK1 (By similarity). Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with NOSTRIN (PubMed:16234328). Binds to TNK2 (PubMed:16257963). Interacts with SNX33 (PubMed:19487689). Interacts with NONO (via second RRM domain); the interaction is direct (PubMed:16767080). Component of a multiprotein complex with NONO and SFPQ; associates with the complex via direct interaction with NONO (PubMed:16767080)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19366662"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22921828"}],"value":"(Microbial infection) Interacts with E.coli effector protein EspF(U) (PubMed:19366662, PubMed:22921828). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U) (PubMed:22921828)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10491394"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9582270"}],"value":"(Microbial infection) Interacts with Shigella flexneri protein IcsA (PubMed:10491394, PubMed:9582270). The interaction with IcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly (PubMed:10491394, 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