{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P04275","secondaryAccessions":["Q8TCE8","Q99806"],"uniProtkbId":"VWF_HUMAN","entryAudit":{"firstPublicDate":"1987-03-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-01-11","entryVersion":280,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"von Willebrand factor"},"shortNames":[{"value":"vWF"}]},"contains":[{"recommendedName":{"fullName":{"value":"von Willebrand antigen 2"}},"alternativeNames":[{"fullName":{"value":"von Willebrand antigen II"}}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"VWF"},"synonyms":[{"value":"F8VWF"}]}],"comments":[{"texts":[{"value":"Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10961880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9218428"}],"value":"Multimeric. Interacts with F8"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P04275","intActId":"EBI-981819"},"interactantTwo":{"uniProtKBAccession":"Q76LX8","geneName":"ADAMTS13","intActId":"EBI-981764"},"numberOfExperiments":19,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04275","intActId":"EBI-981819"},"interactantTwo":{"uniProtKBAccession":"P00451","geneName":"F8","intActId":"EBI-1046394"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04275","intActId":"EBI-981819"},"interactantTwo":{"uniProtKBAccession":"P00451","geneName":"F8","chainId":"PRO_0000002967","intActId":"EBI-21454065"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04275","intActId":"EBI-981819"},"interactantTwo":{"uniProtKBAccession":"P07359","geneName":"GP1BA","intActId":"EBI-297082"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04275","intActId":"EBI-981819"},"interactantTwo":{"uniProtKBAccession":"P04275","geneName":"VWF","intActId":"EBI-981819"},"numberOfExperiments":21,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04275-2","intActId":"EBI-25896548"},"interactantTwo":{"uniProtKBAccession":"Q6XD76","geneName":"ASCL4","intActId":"EBI-10254793"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04275-2","intActId":"EBI-25896548"},"interactantTwo":{"uniProtKBAccession":"Q99944","geneName":"EGFL8","intActId":"EBI-3924130"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04275-2","intActId":"EBI-25896548"},"interactantTwo":{"uniProtKBAccession":"Q6ZQX7-4","geneName":"LIAT1","intActId":"EBI-25830459"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P04275-2","intActId":"EBI-25896548"},"interactantTwo":{"uniProtKBAccession":"Q12888","geneName":"TP53BP1","intActId":"EBI-396540"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Localized to storage granules"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10961880"}],"value":"Secreted","id":"SL-0243"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10961880"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P04275-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P04275-2"],"sequenceIds":["VSP_056527","VSP_056528","VSP_056529"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Plasma"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules"}],"commentType":"DOMAIN"},{"texts":[{"value":"All cysteine residues are involved in intrachain or interchain disulfide bonds"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14760718"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19139490"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"value":"N- and O-glycosylated"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"von Willebrand disease 1","diseaseAccession":"DI-02903","acronym":"VWD1","description":"A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.","diseaseCrossReference":{"database":"MIM","id":"193400"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10887119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11698279"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"von Willebrand disease 2","diseaseAccession":"DI-02904","acronym":"VWD2","description":"A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in altered platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet-dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.","diseaseCrossReference":{"database":"MIM","id":"613554"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12406074"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1409710"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1419803"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1419804"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1420817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1429668"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1672694"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1673047"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1729889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1761120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1832934"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1906179"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2010538"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2011604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21592258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2786201"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7620154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7734373"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7789955"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8011991"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8123843"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8123844"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8338947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8348943"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8376405"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8435341"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8486782"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8547152"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8622978"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"von Willebrand disease 3","diseaseAccession":"DI-02734","acronym":"VWD3","description":"A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.","diseaseCrossReference":{"database":"MIM","id":"277480"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10887119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17190853"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7989040"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8088787"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAB59512.1","note":"Contaminating sequence. Sequence of unknown origin in the N-terminal part.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"vWF","resourceUrl":"http://vwf.hemobase.com/","ftp":false,"note":"von Willebrand factor (vWF) mutation db"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Von_Willebrand_factor","ftp":false,"note":"Von Willebrand factor entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3495266"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":763,"modifier":"EXACT"}},"description":"von Willebrand antigen 2","featureId":"PRO_0000022682"},{"type":"Chain","location":{"start":{"value":764,"modifier":"EXACT"},"end":{"value":2813,"modifier":"EXACT"}},"description":"von Willebrand factor","featureId":"PRO_0000022683"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"VWFD 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Domain","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"TIL 1"},{"type":"Domain","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":560,"modifier":"EXACT"}},"description":"VWFD 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Domain","location":{"start":{"value":652,"modifier":"EXACT"},"end":{"value":707,"modifier":"EXACT"}},"description":"TIL 2"},{"type":"Domain","location":{"start":{"value":776,"modifier":"EXACT"},"end":{"value":827,"modifier":"EXACT"}},"description":"TIL 3"},{"type":"Domain","location":{"start":{"value":865,"modifier":"EXACT"},"end":{"value":1032,"modifier":"EXACT"}},"description":"VWFD 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Domain","location":{"start":{"value":1146,"modifier":"EXACT"},"end":{"value":1196,"modifier":"EXACT"}},"description":"TIL 4"},{"type":"Domain","location":{"start":{"value":1277,"modifier":"EXACT"},"end":{"value":1453,"modifier":"EXACT"}},"description":"VWFA 1; binding site for platelet glycoprotein Ib","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00219"}]},{"type":"Domain","location":{"start":{"value":1498,"modifier":"EXACT"},"end":{"value":1665,"modifier":"EXACT"}},"description":"VWFA 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00219"}]},{"type":"Domain","location":{"start":{"value":1691,"modifier":"EXACT"},"end":{"value":1871,"modifier":"EXACT"}},"description":"VWFA 3; main binding site for collagens type I and III","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00219"}]},{"type":"Domain","location":{"start":{"value":1948,"modifier":"EXACT"},"end":{"value":2124,"modifier":"EXACT"}},"description":"VWFD 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Domain","location":{"start":{"value":2255,"modifier":"EXACT"},"end":{"value":2328,"modifier":"EXACT"}},"description":"VWFC 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00220"}]},{"type":"Domain","location":{"start":{"value":2429,"modifier":"EXACT"},"end":{"value":2495,"modifier":"EXACT"}},"description":"VWFC 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00220"}]},{"type":"Domain","location":{"start":{"value":2580,"modifier":"EXACT"},"end":{"value":2645,"modifier":"EXACT"}},"description":"VWFC 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00220"}]},{"type":"Domain","location":{"start":{"value":2724,"modifier":"EXACT"},"end":{"value":2812,"modifier":"EXACT"}},"description":"CTCK","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00039"}]},{"type":"Region","location":{"start":{"value":764,"modifier":"EXACT"},"end":{"value":787,"modifier":"EXACT"}},"description":"Amino-terminal"},{"type":"Region","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":833,"modifier":"EXACT"}},"description":"E1"},{"type":"Region","location":{"start":{"value":826,"modifier":"EXACT"},"end":{"value":853,"modifier":"EXACT"}},"description":"CX"},{"type":"Region","location":{"start":{"value":2216,"modifier":"EXACT"},"end":{"value":2261,"modifier":"EXACT"}},"description":"E2"},{"type":"Motif","location":{"start":{"value":2507,"modifier":"EXACT"},"end":{"value":2509,"modifier":"EXACT"}},"description":"Cell attachment site"},{"type":"Glycosylation","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":857,"modifier":"EXACT"},"end":{"value":857,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":1147,"modifier":"EXACT"},"end":{"value":1147,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine; atypical","featureId":""},{"type":"Glycosylation","location":{"start":{"value":1231,"modifier":"EXACT"},"end":{"value":1231,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":1248,"modifier":"EXACT"},"end":{"value":1248,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1255,"modifier":"EXACT"},"end":{"value":1255,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1256,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1263,"modifier":"EXACT"},"end":{"value":1263,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3524673"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1468,"modifier":"EXACT"},"end":{"value":1468,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1477,"modifier":"EXACT"},"end":{"value":1477,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1486,"modifier":"EXACT"},"end":{"value":1486,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) serine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1487,"modifier":"EXACT"},"end":{"value":1487,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1515,"modifier":"EXACT"},"end":{"value":1515,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14760718"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19139490"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1574,"modifier":"EXACT"},"end":{"value":1574,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":1679,"modifier":"EXACT"},"end":{"value":1679,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":2223,"modifier":"EXACT"},"end":{"value":2223,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":2290,"modifier":"EXACT"},"end":{"value":2290,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":2298,"modifier":"EXACT"},"end":{"value":2298,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":2357,"modifier":"EXACT"},"end":{"value":2357,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":2400,"modifier":"EXACT"},"end":{"value":2400,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":2546,"modifier":"EXACT"},"end":{"value":2546,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":2585,"modifier":"EXACT"},"end":{"value":2585,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Glycosylation","location":{"start":{"value":2790,"modifier":"EXACT"},"end":{"value":2790,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","featureId":""},{"type":"Disulfide bond","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Disulfide bond","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Disulfide bond","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Disulfide bond","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Disulfide bond","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Disulfide bond","location":{"start":{"value":767,"modifier":"EXACT"},"end":{"value":808,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":776,"modifier":"EXACT"},"end":{"value":804,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":810,"modifier":"EXACT"},"end":{"value":821,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":867,"modifier":"EXACT"},"end":{"value":996,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":889,"modifier":"EXACT"},"end":{"value":1031,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":898,"modifier":"EXACT"},"end":{"value":993,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":914,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1060,"modifier":"EXACT"},"end":{"value":1084,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1071,"modifier":"EXACT"},"end":{"value":1111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1089,"modifier":"EXACT"},"end":{"value":1091,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1126,"modifier":"EXACT"},"end":{"value":1130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1149,"modifier":"EXACT"},"end":{"value":1169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1153,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1196,"modifier":"EXACT"},"end":{"value":1199,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1234,"modifier":"EXACT"},"end":{"value":1237,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1272,"modifier":"EXACT"},"end":{"value":1458,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1669,"modifier":"EXACT"},"end":{"value":1670,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1686,"modifier":"EXACT"},"end":{"value":1872,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1879,"modifier":"EXACT"},"end":{"value":1904,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1899,"modifier":"EXACT"},"end":{"value":1940,"modifier":"EXACT"}},"description":"Or C-1899 with C-1942","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00039"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1927,"modifier":"EXACT"},"end":{"value":2088,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1950,"modifier":"EXACT"},"end":{"value":2085,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1972,"modifier":"EXACT"},"end":{"value":2123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":1993,"modifier":"EXACT"},"end":{"value":2001,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3502076"}]},{"type":"Disulfide bond","location":{"start":{"value":2724,"modifier":"EXACT"},"end":{"value":2774,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":2739,"modifier":"EXACT"},"end":{"value":2788,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":2750,"modifier":"EXACT"},"end":{"value":2804,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":2754,"modifier":"EXACT"},"end":{"value":2806,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":null,"modifier":"UNKNOWN"},"end":{"value":2811,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_056527","alternativeSequence":{"originalSequence":"MIPARFAGVLLALALILP","alternativeSequences":["MGAQDEEEGIQDLDGLLVFDKIVEVTLLNLPWYNEETEGQRGEMTAPKSPRAKIR"]}},{"type":"Alternative sequence","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_056528","alternativeSequence":{"originalSequence":"GLWEQCQLLKSTSVFARCHPLVDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSPCARTCQS","alternativeSequences":["EEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMYSIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSKI"]}},{"type":"Alternative sequence","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":2813,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_056529","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"in VWD1 and VWD3; defect in secretion and formation of multimers; dbSNP:rs61753997","featureCrossReferences":[{"database":"dbSNP","id":"rs61753997"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10887119"}],"featureId":"VAR_010242","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"in dbSNP:rs1800387","featureCrossReferences":[{"database":"dbSNP","id":"rs1800387"}],"featureId":"VAR_057023","alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"in VWD3; dbSNP:rs62643626","featureCrossReferences":[{"database":"dbSNP","id":"rs62643626"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7989040"}],"featureId":"VAR_005782","alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":471,"modifier":"EXACT"},"end":{"value":471,"modifier":"EXACT"}},"description":"in dbSNP:rs1800377","featureCrossReferences":[{"database":"dbSNP","id":"rs1800377"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2584182"}],"featureId":"VAR_060591","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"in dbSNP:rs1800378","featureCrossReferences":[{"database":"dbSNP","id":"rs1800378"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3019665"}],"featureId":"VAR_024553","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":528,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61754010","featureCrossReferences":[{"database":"dbSNP","id":"rs61754010"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8011991"}],"featureId":"VAR_005783","alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61754011","featureCrossReferences":[{"database":"dbSNP","id":"rs61754011"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7789955"}],"featureId":"VAR_005784","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":740,"modifier":"EXACT"},"end":{"value":740,"modifier":"EXACT"}},"description":"in dbSNP:rs2228317","featureCrossReferences":[{"database":"dbSNP","id":"rs2228317"}],"featureId":"VAR_057024","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61748476","featureCrossReferences":[{"database":"dbSNP","id":"rs61748476"}],"featureId":"VAR_009141","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":789,"modifier":"EXACT"},"end":{"value":789,"modifier":"EXACT"}},"description":"in dbSNP:rs1063856","featureCrossReferences":[{"database":"dbSNP","id":"rs1063856"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2864688"}],"featureId":"VAR_005785","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"in VWD2; Normandy type; dbSNP:rs61748477","featureCrossReferences":[{"database":"dbSNP","id":"rs61748477"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1906179"}],"featureId":"VAR_005786","alternativeSequence":{"originalSequence":"T","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":816,"modifier":"EXACT"},"end":{"value":816,"modifier":"EXACT"}},"description":"in VWD2; Normandy type; dbSNP:rs121964894","featureCrossReferences":[{"database":"dbSNP","id":"rs121964894"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1832934"}],"featureId":"VAR_005787","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":852,"modifier":"EXACT"},"end":{"value":852,"modifier":"EXACT"}},"description":"in dbSNP:rs216321","featureCrossReferences":[{"database":"dbSNP","id":"rs216321"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2584182"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2864688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3019665"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3488076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3489923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3524673"}],"featureId":"VAR_005788","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":854,"modifier":"EXACT"},"end":{"value":854,"modifier":"EXACT"}},"description":"in VWD2; Normandy type; dbSNP:rs41276738","featureCrossReferences":[{"database":"dbSNP","id":"rs41276738"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1832934"}],"featureId":"VAR_005789","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":857,"modifier":"EXACT"},"end":{"value":857,"modifier":"EXACT"}},"description":"","featureId":"VAR_005790","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":885,"modifier":"EXACT"},"end":{"value":885,"modifier":"EXACT"}},"description":"in dbSNP:rs11064002","featureCrossReferences":[{"database":"dbSNP","id":"rs11064002"}],"featureId":"VAR_057025","alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1060,"modifier":"EXACT"},"end":{"value":1060,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61748497","featureCrossReferences":[{"database":"dbSNP","id":"rs61748497"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12406074"}],"featureId":"VAR_028446","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1149,"modifier":"EXACT"},"end":{"value":1149,"modifier":"EXACT"}},"description":"in VWD1; reduced secretion of homodimers and heterodimers with wild type VWD and increased degradation by the proteasome; dbSNP:rs61748511","featureCrossReferences":[{"database":"dbSNP","id":"rs61748511"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11698279"}],"featureId":"VAR_064925","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1266,"modifier":"EXACT"},"end":{"value":1266,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749370","featureCrossReferences":[{"database":"dbSNP","id":"rs61749370"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8486782"}],"featureId":"VAR_005791","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":1268,"modifier":"EXACT"},"end":{"value":1268,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749371","featureCrossReferences":[{"database":"dbSNP","id":"rs61749371"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8376405"}],"featureId":"VAR_005792","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":1272,"modifier":"EXACT"},"end":{"value":1272,"modifier":"EXACT"}},"description":"in VWD2; subtype 2A; dbSNP:rs63524161","featureCrossReferences":[{"database":"dbSNP","id":"rs63524161"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21592258"}],"featureId":"VAR_067340","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":1272,"modifier":"EXACT"},"end":{"value":1272,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749372","featureCrossReferences":[{"database":"dbSNP","id":"rs61749372"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1419804"}],"featureId":"VAR_005793","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1306,"modifier":"EXACT"},"end":{"value":1306,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749384","featureCrossReferences":[{"database":"dbSNP","id":"rs61749384"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1419803"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1420817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1672694"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2010538"}],"featureId":"VAR_005794","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":1308,"modifier":"EXACT"},"end":{"value":1308,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749387","featureCrossReferences":[{"database":"dbSNP","id":"rs61749387"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1419803"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1672694"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1761120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2010538"}],"featureId":"VAR_005795","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":1313,"modifier":"EXACT"},"end":{"value":1313,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749392","featureCrossReferences":[{"database":"dbSNP","id":"rs61749392"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2011604"}],"featureId":"VAR_005796","alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":1314,"modifier":"EXACT"},"end":{"value":1314,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749393","featureCrossReferences":[{"database":"dbSNP","id":"rs61749393"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1419803"}],"featureId":"VAR_005797","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":1316,"modifier":"EXACT"},"end":{"value":1316,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749397","featureCrossReferences":[{"database":"dbSNP","id":"rs61749397"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1420817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1672694"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1729889"}],"featureId":"VAR_005798","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":1318,"modifier":"EXACT"},"end":{"value":1318,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs372028373","featureCrossReferences":[{"database":"dbSNP","id":"rs372028373"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1419803"}],"featureId":"VAR_005799","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":1324,"modifier":"EXACT"},"end":{"value":1324,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749398","featureCrossReferences":[{"database":"dbSNP","id":"rs61749398"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1409710"}],"featureId":"VAR_005800","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1341,"modifier":"EXACT"},"end":{"value":1341,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61749403","featureCrossReferences":[{"database":"dbSNP","id":"rs61749403"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1672694"}],"featureId":"VAR_005801","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":1374,"modifier":"EXACT"},"end":{"value":1374,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750071","featureCrossReferences":[{"database":"dbSNP","id":"rs61750071"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7620154"}],"featureId":"VAR_005802","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":1374,"modifier":"EXACT"},"end":{"value":1374,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750072","featureCrossReferences":[{"database":"dbSNP","id":"rs61750072"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7620154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7734373"}],"featureId":"VAR_005803","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1381,"modifier":"EXACT"},"end":{"value":1381,"modifier":"EXACT"}},"description":"in dbSNP:rs216311","featureCrossReferences":[{"database":"dbSNP","id":"rs216311"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1988024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2584182"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2864688"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3019665"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3488076"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3489923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3524673"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9373253"}],"featureId":"VAR_005804","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":1399,"modifier":"EXACT"},"end":{"value":1399,"modifier":"EXACT"}},"description":"in dbSNP:rs1800382","featureCrossReferences":[{"database":"dbSNP","id":"rs1800382"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1672694"}],"featureId":"VAR_005805","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1460,"modifier":"EXACT"},"end":{"value":1460,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750088","featureCrossReferences":[{"database":"dbSNP","id":"rs61750088"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8123843"}],"featureId":"VAR_005806","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":1461,"modifier":"EXACT"},"end":{"value":1461,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750089","featureCrossReferences":[{"database":"dbSNP","id":"rs61750089"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8547152"}],"featureId":"VAR_005807","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":1472,"modifier":"EXACT"},"end":{"value":1472,"modifier":"EXACT"}},"description":"in dbSNP:rs1800383","featureCrossReferences":[{"database":"dbSNP","id":"rs1800383"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1988024"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2584182"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3489923"}],"featureId":"VAR_029656","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1514,"modifier":"EXACT"},"end":{"value":1514,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750101","featureCrossReferences":[{"database":"dbSNP","id":"rs61750101"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8435341"}],"featureId":"VAR_005808","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":1540,"modifier":"EXACT"},"end":{"value":1540,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs267607342","featureCrossReferences":[{"database":"dbSNP","id":"rs267607342"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8123844"}],"featureId":"VAR_005809","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":1565,"modifier":"EXACT"},"end":{"value":1565,"modifier":"EXACT"}},"description":"in dbSNP:rs1800385","featureCrossReferences":[{"database":"dbSNP","id":"rs1800385"}],"featureId":"VAR_014630","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":1570,"modifier":"EXACT"},"end":{"value":1570,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_036276","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":1584,"modifier":"EXACT"},"end":{"value":1584,"modifier":"EXACT"}},"description":"exhibits increased in susceptibility to proteolysis by ADAMTS13; dbSNP:rs1800386","featureCrossReferences":[{"database":"dbSNP","id":"rs1800386"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15755288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8348943"}],"featureId":"VAR_005810","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":1597,"modifier":"EXACT"},"end":{"value":1597,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750117","featureCrossReferences":[{"database":"dbSNP","id":"rs61750117"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8348943"}],"featureId":"VAR_005811","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":1597,"modifier":"EXACT"},"end":{"value":1597,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750577","featureCrossReferences":[{"database":"dbSNP","id":"rs61750577"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8338947"}],"featureId":"VAR_005812","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":1597,"modifier":"EXACT"},"end":{"value":1597,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750117","featureCrossReferences":[{"database":"dbSNP","id":"rs61750117"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2786201"}],"featureId":"VAR_005813","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":1607,"modifier":"EXACT"},"end":{"value":1607,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750579","featureCrossReferences":[{"database":"dbSNP","id":"rs61750579"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2786201"}],"featureId":"VAR_005814","alternativeSequence":{"originalSequence":"V","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":1609,"modifier":"EXACT"},"end":{"value":1609,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750580","featureCrossReferences":[{"database":"dbSNP","id":"rs61750580"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8338947"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8348943"}],"featureId":"VAR_005815","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1613,"modifier":"EXACT"},"end":{"value":1613,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750581","featureCrossReferences":[{"database":"dbSNP","id":"rs61750581"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2010538"}],"featureId":"VAR_005816","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":1628,"modifier":"EXACT"},"end":{"value":1628,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750584","featureCrossReferences":[{"database":"dbSNP","id":"rs61750584"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1420817"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1673047"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8123844"}],"featureId":"VAR_005817","alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":1638,"modifier":"EXACT"},"end":{"value":1638,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750588","featureCrossReferences":[{"database":"dbSNP","id":"rs61750588"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1429668"}],"featureId":"VAR_005818","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":1648,"modifier":"EXACT"},"end":{"value":1648,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750590","featureCrossReferences":[{"database":"dbSNP","id":"rs61750590"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1420817"}],"featureId":"VAR_005819","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1665,"modifier":"EXACT"},"end":{"value":1665,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61750596","featureCrossReferences":[{"database":"dbSNP","id":"rs61750596"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8338947"}],"featureId":"VAR_005820","alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":2063,"modifier":"EXACT"},"end":{"value":2063,"modifier":"EXACT"}},"description":"in VWD3; likely benign; dbSNP:rs61750615","featureCrossReferences":[{"database":"dbSNP","id":"rs61750615"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17190853"}],"featureId":"VAR_009142","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":2178,"modifier":"EXACT"},"end":{"value":2178,"modifier":"EXACT"}},"description":"in dbSNP:rs34230288","featureCrossReferences":[{"database":"dbSNP","id":"rs34230288"}],"featureId":"VAR_057026","alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":2185,"modifier":"EXACT"},"end":{"value":2185,"modifier":"EXACT"}},"description":"in dbSNP:rs2229446","featureCrossReferences":[{"database":"dbSNP","id":"rs2229446"}],"featureId":"VAR_057027","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":2362,"modifier":"EXACT"},"end":{"value":2362,"modifier":"EXACT"}},"description":"in VWD3; dbSNP:rs61750630","featureCrossReferences":[{"database":"dbSNP","id":"rs61750630"}],"featureId":"VAR_009143","alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":2546,"modifier":"EXACT"},"end":{"value":2546,"modifier":"EXACT"}},"description":"in VWD3; dbSNP:rs61751298","featureCrossReferences":[{"database":"dbSNP","id":"rs61751298"}],"featureId":"VAR_009144","alternativeSequence":{"originalSequence":"N","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":2705,"modifier":"EXACT"},"end":{"value":2705,"modifier":"EXACT"}},"description":"in dbSNP:rs7962217","featureCrossReferences":[{"database":"dbSNP","id":"rs7962217"}],"featureId":"VAR_057028","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":2739,"modifier":"EXACT"},"end":{"value":2739,"modifier":"EXACT"}},"description":"in VWD3; dbSNP:rs61751305","featureCrossReferences":[{"database":"dbSNP","id":"rs61751305"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8088787"}],"featureId":"VAR_005821","alternativeSequence":{"originalSequence":"C","alternativeSequences":["Y"]}},{"type":"Natural variant","location":{"start":{"value":2773,"modifier":"EXACT"},"end":{"value":2773,"modifier":"EXACT"}},"description":"in VWD2; dbSNP:rs61751310","featureCrossReferences":[{"database":"dbSNP","id":"rs61751310"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8622978"}],"featureId":"VAR_005822","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":1149,"modifier":"EXACT"},"end":{"value":1149,"modifier":"EXACT"}},"description":"Reduced secretion and increased intracellular retention. Similar phenotype; when associated with S-1169.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11698279"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":1169,"modifier":"EXACT"},"end":{"value":1169,"modifier":"EXACT"}},"description":"Reduced secretion and increased intracellular retention. Similar phenotype; when associated with R-1149.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11698279"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":770,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"in Ref. 11; AAB59512","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":804,"modifier":"EXACT"},"end":{"value":804,"modifier":"EXACT"}},"description":"in Ref. 10; AA sequence and 11; AAB59512","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":1914,"modifier":"EXACT"},"end":{"value":1914,"modifier":"EXACT"}},"description":"in Ref. 1; CAA27972","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":2168,"modifier":"EXACT"},"end":{"value":2168,"modifier":"EXACT"}},"description":"in Ref. 10; AA sequence","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Beta strand","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPQ"}]},{"type":"Beta strand","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":88,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3D"}]},{"type":"Beta strand","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WN3"}]},{"type":"Beta strand","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPQ"}]},{"type":"Turn","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3D"}]},{"type":"Helix","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Helix","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPQ"}]},{"type":"Helix","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WN4"}]},{"type":"Turn","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZWH"}]},{"type":"Beta strand","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZWH"}]},{"type":"Helix","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":391,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":392,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":395,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":424,"modifier":"EXACT"},"end":{"value":431,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":448,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":453,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":460,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPQ"}]},{"type":"Beta strand","location":{"start":{"value":464,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":469,"modifier":"EXACT"},"end":{"value":471,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZWH"}]},{"type":"Beta strand","location":{"start":{"value":490,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":497,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":503,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":514,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":522,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":527,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WN3"}]},{"type":"Helix","location":{"start":{"value":532,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WN4"}]},{"type":"Beta strand","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":546,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":553,"modifier":"EXACT"},"end":{"value":555,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":557,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":560,"modifier":"EXACT"},"end":{"value":562,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":569,"modifier":"EXACT"},"end":{"value":571,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":574,"modifier":"EXACT"},"end":{"value":576,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":577,"modifier":"EXACT"},"end":{"value":583,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":585,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":590,"modifier":"EXACT"},"end":{"value":592,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":596,"modifier":"EXACT"},"end":{"value":598,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":612,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Helix","location":{"start":{"value":618,"modifier":"EXACT"},"end":{"value":636,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Turn","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":667,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZWH"}]},{"type":"Helix","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":672,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":681,"modifier":"EXACT"},"end":{"value":683,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":688,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":695,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":697,"modifier":"EXACT"},"end":{"value":699,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZWH"}]},{"type":"Beta strand","location":{"start":{"value":701,"modifier":"EXACT"},"end":{"value":703,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Helix","location":{"start":{"value":704,"modifier":"EXACT"},"end":{"value":706,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":709,"modifier":"EXACT"},"end":{"value":711,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":714,"modifier":"EXACT"},"end":{"value":716,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":721,"modifier":"EXACT"},"end":{"value":723,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":728,"modifier":"EXACT"},"end":{"value":736,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":769,"modifier":"EXACT"},"end":{"value":771,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZWH"}]},{"type":"Beta strand","location":{"start":{"value":772,"modifier":"EXACT"},"end":{"value":774,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":775,"modifier":"EXACT"},"end":{"value":777,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2MHQ"}]},{"type":"Beta strand","location":{"start":{"value":778,"modifier":"EXACT"},"end":{"value":781,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KWO"}]},{"type":"Helix","location":{"start":{"value":786,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":792,"modifier":"EXACT"},"end":{"value":794,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":795,"modifier":"EXACT"},"end":{"value":797,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":798,"modifier":"EXACT"},"end":{"value":800,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2MHP"}]},{"type":"Helix","location":{"start":{"value":804,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":807,"modifier":"EXACT"},"end":{"value":809,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":814,"modifier":"EXACT"},"end":{"value":816,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":818,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":824,"modifier":"EXACT"},"end":{"value":826,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":829,"modifier":"EXACT"},"end":{"value":831,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":834,"modifier":"EXACT"},"end":{"value":836,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":841,"modifier":"EXACT"},"end":{"value":844,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":847,"modifier":"EXACT"},"end":{"value":852,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":855,"modifier":"EXACT"},"end":{"value":858,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":861,"modifier":"EXACT"},"end":{"value":864,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":865,"modifier":"EXACT"},"end":{"value":870,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Turn","location":{"start":{"value":871,"modifier":"EXACT"},"end":{"value":873,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":874,"modifier":"EXACT"},"end":{"value":876,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":882,"modifier":"EXACT"},"end":{"value":884,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":889,"modifier":"EXACT"},"end":{"value":896,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":898,"modifier":"EXACT"},"end":{"value":900,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":905,"modifier":"EXACT"},"end":{"value":913,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":915,"modifier":"EXACT"},"end":{"value":917,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KWO"}]},{"type":"Helix","location":{"start":{"value":918,"modifier":"EXACT"},"end":{"value":920,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KWO"}]},{"type":"Beta strand","location":{"start":{"value":922,"modifier":"EXACT"},"end":{"value":929,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":937,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":940,"modifier":"EXACT"},"end":{"value":945,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Turn","location":{"start":{"value":950,"modifier":"EXACT"},"end":{"value":952,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Beta strand","location":{"start":{"value":953,"modifier":"EXACT"},"end":{"value":958,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":961,"modifier":"EXACT"},"end":{"value":974,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":976,"modifier":"EXACT"},"end":{"value":978,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":980,"modifier":"EXACT"},"end":{"value":984,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":986,"modifier":"EXACT"},"end":{"value":988,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Turn","location":{"start":{"value":989,"modifier":"EXACT"},"end":{"value":991,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KWO"}]},{"type":"Beta strand","location":{"start":{"value":999,"modifier":"EXACT"},"end":{"value":1001,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Helix","location":{"start":{"value":1003,"modifier":"EXACT"},"end":{"value":1005,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1012,"modifier":"EXACT"},"end":{"value":1014,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPQ"}]},{"type":"Helix","location":{"start":{"value":1018,"modifier":"EXACT"},"end":{"value":1023,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1026,"modifier":"EXACT"},"end":{"value":1028,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Beta strand","location":{"start":{"value":1029,"modifier":"EXACT"},"end":{"value":1031,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KWO"}]},{"type":"Helix","location":{"start":{"value":1032,"modifier":"EXACT"},"end":{"value":1036,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":1037,"modifier":"EXACT"},"end":{"value":1039,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":1044,"modifier":"EXACT"},"end":{"value":1046,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":1050,"modifier":"EXACT"},"end":{"value":1060,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":1061,"modifier":"EXACT"},"end":{"value":1064,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":1066,"modifier":"EXACT"},"end":{"value":1074,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":1078,"modifier":"EXACT"},"end":{"value":1088,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1089,"modifier":"EXACT"},"end":{"value":1091,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZWH"}]},{"type":"Beta strand","location":{"start":{"value":1094,"modifier":"EXACT"},"end":{"value":1096,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":1098,"modifier":"EXACT"},"end":{"value":1113,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1123,"modifier":"EXACT"},"end":{"value":1126,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":1132,"modifier":"EXACT"},"end":{"value":1135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPP"}]},{"type":"Helix","location":{"start":{"value":1136,"modifier":"EXACT"},"end":{"value":1138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1143,"modifier":"EXACT"},"end":{"value":1153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1156,"modifier":"EXACT"},"end":{"value":1158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KWO"}]},{"type":"Helix","location":{"start":{"value":1162,"modifier":"EXACT"},"end":{"value":1164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WPQ"}]},{"type":"Beta strand","location":{"start":{"value":1166,"modifier":"EXACT"},"end":{"value":1176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1179,"modifier":"EXACT"},"end":{"value":1181,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7ZWH"}]},{"type":"Beta strand","location":{"start":{"value":1182,"modifier":"EXACT"},"end":{"value":1184,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Turn","location":{"start":{"value":1185,"modifier":"EXACT"},"end":{"value":1188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1189,"modifier":"EXACT"},"end":{"value":1191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":1193,"modifier":"EXACT"},"end":{"value":1195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1198,"modifier":"EXACT"},"end":{"value":1201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1204,"modifier":"EXACT"},"end":{"value":1207,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1211,"modifier":"EXACT"},"end":{"value":1215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Turn","location":{"start":{"value":1219,"modifier":"EXACT"},"end":{"value":1221,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1223,"modifier":"EXACT"},"end":{"value":1230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Beta strand","location":{"start":{"value":1232,"modifier":"EXACT"},"end":{"value":1236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6N29"}]},{"type":"Helix","location":{"start":{"value":1237,"modifier":"EXACT"},"end":{"value":1239,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7KWO"}]},{"type":"Beta strand","location":{"start":{"value":1267,"modifier":"EXACT"},"end":{"value":1269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Turn","location":{"start":{"value":1270,"modifier":"EXACT"},"end":{"value":1273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4C29"}]},{"type":"Beta strand","location":{"start":{"value":1276,"modifier":"EXACT"},"end":{"value":1283,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Beta strand","location":{"start":{"value":1285,"modifier":"EXACT"},"end":{"value":1288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4C2B"}]},{"type":"Helix","location":{"start":{"value":1290,"modifier":"EXACT"},"end":{"value":1305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Turn","location":{"start":{"value":1307,"modifier":"EXACT"},"end":{"value":1310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1SQ0"}]},{"type":"Beta strand","location":{"start":{"value":1313,"modifier":"EXACT"},"end":{"value":1329,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1337,"modifier":"EXACT"},"end":{"value":1345,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1347,"modifier":"EXACT"},"end":{"value":1349,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1357,"modifier":"EXACT"},"end":{"value":1363,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1364,"modifier":"EXACT"},"end":{"value":1368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Beta strand","location":{"start":{"value":1369,"modifier":"EXACT"},"end":{"value":1371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Beta strand","location":{"start":{"value":1377,"modifier":"EXACT"},"end":{"value":1385,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1388,"modifier":"EXACT"},"end":{"value":1390,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8D3C"}]},{"type":"Helix","location":{"start":{"value":1391,"modifier":"EXACT"},"end":{"value":1393,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1394,"modifier":"EXACT"},"end":{"value":1396,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1U0N"}]},{"type":"Helix","location":{"start":{"value":1397,"modifier":"EXACT"},"end":{"value":1406,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Beta strand","location":{"start":{"value":1409,"modifier":"EXACT"},"end":{"value":1417,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1422,"modifier":"EXACT"},"end":{"value":1431,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1433,"modifier":"EXACT"},"end":{"value":1435,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4C29"}]},{"type":"Beta strand","location":{"start":{"value":1438,"modifier":"EXACT"},"end":{"value":1442,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1443,"modifier":"EXACT"},"end":{"value":1445,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1446,"modifier":"EXACT"},"end":{"value":1460,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Helix","location":{"start":{"value":1462,"modifier":"EXACT"},"end":{"value":1467,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5BV8"}]},{"type":"Beta strand","location":{"start":{"value":1498,"modifier":"EXACT"},"end":{"value":1504,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Turn","location":{"start":{"value":1507,"modifier":"EXACT"},"end":{"value":1509,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Helix","location":{"start":{"value":1511,"modifier":"EXACT"},"end":{"value":1527,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Beta strand","location":{"start":{"value":1534,"modifier":"EXACT"},"end":{"value":1550,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Helix","location":{"start":{"value":1558,"modifier":"EXACT"},"end":{"value":1567,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Helix","location":{"start":{"value":1568,"modifier":"EXACT"},"end":{"value":1570,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GXB"}]},{"type":"Helix","location":{"start":{"value":1578,"modifier":"EXACT"},"end":{"value":1584,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Helix","location":{"start":{"value":1585,"modifier":"EXACT"},"end":{"value":1589,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Helix","location":{"start":{"value":1592,"modifier":"EXACT"},"end":{"value":1594,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Helix","location":{"start":{"value":1595,"modifier":"EXACT"},"end":{"value":1599,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GXB"}]},{"type":"Beta strand","location":{"start":{"value":1602,"modifier":"EXACT"},"end":{"value":1608,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Helix","location":{"start":{"value":1618,"modifier":"EXACT"},"end":{"value":1620,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3GXB"}]},{"type":"Beta strand","location":{"start":{"value":1623,"modifier":"EXACT"},"end":{"value":1630,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Turn","location":{"start":{"value":1631,"modifier":"EXACT"},"end":{"value":1633,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Helix","location":{"start":{"value":1636,"modifier":"EXACT"},"end":{"value":1643,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Beta strand","location":{"start":{"value":1649,"modifier":"EXACT"},"end":{"value":1652,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Turn","location":{"start":{"value":1654,"modifier":"EXACT"},"end":{"value":1656,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Helix","location":{"start":{"value":1657,"modifier":"EXACT"},"end":{"value":1670,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3ZQK"}]},{"type":"Beta strand","location":{"start":{"value":1690,"modifier":"EXACT"},"end":{"value":1697,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Beta strand","location":{"start":{"value":1699,"modifier":"EXACT"},"end":{"value":1702,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Helix","location":{"start":{"value":1704,"modifier":"EXACT"},"end":{"value":1720,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Beta strand","location":{"start":{"value":1727,"modifier":"EXACT"},"end":{"value":1743,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Beta strand","location":{"start":{"value":1745,"modifier":"EXACT"},"end":{"value":1747,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DMU"}]},{"type":"Helix","location":{"start":{"value":1751,"modifier":"EXACT"},"end":{"value":1759,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Helix","location":{"start":{"value":1770,"modifier":"EXACT"},"end":{"value":1782,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Helix","location":{"start":{"value":1784,"modifier":"EXACT"},"end":{"value":1786,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2ADF"}]},{"type":"Beta strand","location":{"start":{"value":1792,"modifier":"EXACT"},"end":{"value":1800,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Helix","location":{"start":{"value":1809,"modifier":"EXACT"},"end":{"value":1817,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Beta strand","location":{"start":{"value":1820,"modifier":"EXACT"},"end":{"value":1831,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Helix","location":{"start":{"value":1833,"modifier":"EXACT"},"end":{"value":1839,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Helix","location":{"start":{"value":1841,"modifier":"EXACT"},"end":{"value":1847,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Beta strand","location":{"start":{"value":1849,"modifier":"EXACT"},"end":{"value":1853,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Helix","location":{"start":{"value":1856,"modifier":"EXACT"},"end":{"value":1862,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Beta strand","location":{"start":{"value":1863,"modifier":"EXACT"},"end":{"value":1865,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2ADF"}]},{"type":"Helix","location":{"start":{"value":1866,"modifier":"EXACT"},"end":{"value":1870,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1ATZ"}]},{"type":"Beta strand","location":{"start":{"value":2497,"modifier":"EXACT"},"end":{"value":2503,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Turn","location":{"start":{"value":2506,"modifier":"EXACT"},"end":{"value":2508,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Beta strand","location":{"start":{"value":2511,"modifier":"EXACT"},"end":{"value":2516,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Beta strand","location":{"start":{"value":2520,"modifier":"EXACT"},"end":{"value":2522,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Beta strand","location":{"start":{"value":2524,"modifier":"EXACT"},"end":{"value":2527,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Beta strand","location":{"start":{"value":2529,"modifier":"EXACT"},"end":{"value":2536,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Beta strand","location":{"start":{"value":2539,"modifier":"EXACT"},"end":{"value":2546,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Beta strand","location":{"start":{"value":2563,"modifier":"EXACT"},"end":{"value":2565,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Beta strand","location":{"start":{"value":2568,"modifier":"EXACT"},"end":{"value":2571,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Beta strand","location":{"start":{"value":2574,"modifier":"EXACT"},"end":{"value":2576,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6FWN"}]},{"type":"Beta strand","location":{"start":{"value":2648,"modifier":"EXACT"},"end":{"value":2653,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P4N"}]},{"type":"Turn","location":{"start":{"value":2654,"modifier":"EXACT"},"end":{"value":2656,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P4N"}]},{"type":"Beta strand","location":{"start":{"value":2657,"modifier":"EXACT"},"end":{"value":2661,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P4N"}]},{"type":"Beta strand","location":{"start":{"value":2669,"modifier":"EXACT"},"end":{"value":2678,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P4N"}]},{"type":"Beta strand","location":{"start":{"value":2684,"modifier":"EXACT"},"end":{"value":2689,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P4N"}]},{"type":"Helix","location":{"start":{"value":2692,"modifier":"EXACT"},"end":{"value":2695,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P4N"}]},{"type":"Beta strand","location":{"start":{"value":2698,"modifier":"EXACT"},"end":{"value":2702,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P4N"}]},{"type":"Beta strand","location":{"start":{"value":2708,"modifier":"EXACT"},"end":{"value":2710,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P4N"}]},{"type":"Beta strand","location":{"start":{"value":2717,"modifier":"EXACT"},"end":{"value":2719,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7P4N"}]},{"type":"Beta strand","location":{"start":{"value":2728,"modifier":"EXACT"},"end":{"value":2732,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4NT5"}]},{"type":"Beta strand","location":{"start":{"value":2739,"modifier":"EXACT"},"end":{"value":2743,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4NT5"}]},{"type":"Beta strand","location":{"start":{"value":2745,"modifier":"EXACT"},"end":{"value":2749,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4NT5"}]},{"type":"Beta strand","location":{"start":{"value":2756,"modifier":"EXACT"},"end":{"value":2761,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4NT5"}]},{"type":"Turn","location":{"start":{"value":2762,"modifier":"EXACT"},"end":{"value":2765,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4NT5"}]},{"type":"Beta strand","location":{"start":{"value":2766,"modifier":"EXACT"},"end":{"value":2787,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4NT5"}]},{"type":"Beta strand","location":{"start":{"value":2793,"modifier":"EXACT"},"end":{"value":2801,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4NT5"}]},{"type":"Beta strand","location":{"start":{"value":2804,"modifier":"EXACT"},"end":{"value":2809,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4NT5"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0852","category":"Disease","name":"von Willebrand disease"}],"references":[{"referenceNumber":1,"citation":{"id":"3489923","citationType":"journal article","authors":["Bonthron D.","Orr E.C.","Mitsock L.M.","Ginsburg D.","Handin R.I.","Orkin S.H."],"citationCrossReferences":[{"database":"PubMed","id":"3489923"},{"database":"DOI","id":"10.1093/nar/14.17.7125"}],"title":"Nucleotide sequence of pre-pro-von Willebrand factor cDNA.","publicationDate":"1986","journal":"Nucleic Acids Res.","firstPage":"7125","lastPage":"7128","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANTS ARG-852; ALA-1381 AND HIS-1472"]},{"referenceNumber":2,"citation":{"id":"2584182","citationType":"journal article","authors":["Mancuso D.J.","Tuley E.A.","Westfield L.A.","Worrall N.K.","Shelton-Inloes B.B.","Sorace J.M.","Alevy Y.G.","Sadler J.E."],"citationCrossReferences":[{"database":"PubMed","id":"2584182"},{"database":"DOI","id":"10.1016/s0021-9258(19)47144-5"}],"title":"Structure of the gene for human von Willebrand factor.","publicationDate":"1989","journal":"J. Biol. Chem.","firstPage":"19514","lastPage":"19527","volume":"264"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","VARIANTS ILE-471; ARG-852; ALA-1381 AND HIS-1472"]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.H.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.-L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-56FTJV1JKRRTT","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"3019665","citationType":"journal article","authors":["Verweij C.L.","Diergaarde P.J.","Hart M.","Pannekoek H."],"citationCrossReferences":[{"database":"PubMed","id":"3019665"},{"database":"DOI","id":"10.1002/j.1460-2075.1986.tb04435.x"}],"title":"Full-length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit.","publicationDate":"1986","journal":"EMBO J.","firstPage":"1839","lastPage":"1847","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-1400 (ISOFORM 1)","VARIANTS ARG-484; ARG-852 AND ALA-1381"]},{"referenceNumber":7,"citation":{"id":"CI-4UOPLNCT83J9H","citationType":"journal article","authors":["Verweij C.L.","Diergaarde P.J.","Hart M.","Pannekoek H."],"publicationDate":"1986","journal":"EMBO J.","firstPage":"3074","lastPage":"3074","volume":"5"},"referencePositions":["ERRATUM OF PUBMED:3019665"]},{"referenceNumber":8,"citation":{"id":"2828057","citationType":"journal article","authors":["Bonthron D.","Orkin S.H."],"citationCrossReferences":[{"database":"PubMed","id":"2828057"},{"database":"DOI","id":"10.1111/j.1432-1033.1988.tb13757.x"}],"title":"The human von Willebrand factor gene. Structure of the 5' region.","publicationDate":"1988","journal":"Eur. J. Biochem.","firstPage":"51","lastPage":"57","volume":"171"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-178"]},{"referenceNumber":9,"citation":{"id":"3495266","citationType":"journal article","authors":["Shelton-Inloes B.B.","Broze G.J. Jr.","Miletich J.P.","Sadler J.E."],"citationCrossReferences":[{"database":"PubMed","id":"3495266"},{"database":"DOI","id":"10.1016/s0006-291x(87)80016-5"}],"title":"Evolution of human von Willebrand factor: cDNA sequence polymorphisms, repeated domains, and relationship to von Willebrand antigen II.","publicationDate":"1987","journal":"Biochem. Biophys. Res. Commun.","firstPage":"657","lastPage":"665","volume":"144"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1-120 (ISOFORM 1)","PROTEIN SEQUENCE OF 23-56"],"referenceComments":[{"value":"Umbilical vein endothelial cell","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"3524673","citationType":"journal article","authors":["Titani K.","Kumar S.","Takio K.","Ericsson L.H.","Wade R.D.","Ashida K.","Walsh K.A.","Chopek M.W.","Sadler J.E.","Fujikawa K."],"citationCrossReferences":[{"database":"PubMed","id":"3524673"},{"database":"DOI","id":"10.1021/bi00359a015"}],"title":"Amino acid sequence of human von Willebrand factor.","publicationDate":"1986","journal":"Biochemistry","firstPage":"3171","lastPage":"3184","volume":"25"},"referencePositions":["PROTEIN SEQUENCE OF 764-2813","VARIANTS ARG-852 AND ALA-1381"]},{"referenceNumber":11,"citation":{"id":"2864688","citationType":"journal article","authors":["Sadler J.E.","Shelton-Inloes B.B.","Sorace J.M.","Harlan J.M.","Titani K.","Davie E.W."],"citationCrossReferences":[{"database":"PubMed","id":"2864688"},{"database":"DOI","id":"10.1073/pnas.82.19.6394"}],"title":"Cloning and characterization of two cDNAs coding for human von Willebrand factor.","publicationDate":"1985","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6394","lastPage":"6398","volume":"82"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 744-873 AND 1289-2813 (ISOFORM 1)","VARIANTS ALA-789; ARG-852 AND ALA-1381"]},{"referenceNumber":12,"citation":{"id":"12665801","citationType":"journal article","authors":["Gevaert K.","Goethals M.","Martens L.","Van Damme J.","Staes A.","Thomas G.R.","Vandekerckhove J."],"citationCrossReferences":[{"database":"PubMed","id":"12665801"},{"database":"DOI","id":"10.1038/nbt810"}],"title":"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.","publicationDate":"2003","journal":"Nat. Biotechnol.","firstPage":"566","lastPage":"569","volume":"21"},"referencePositions":["PROTEIN SEQUENCE OF 764-782"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"3488076","citationType":"journal article","authors":["Shelton-Inloes B.B.","Titani K.","Sadler J.E."],"citationCrossReferences":[{"database":"PubMed","id":"3488076"},{"database":"DOI","id":"10.1021/bi00359a014"}],"title":"cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms.","publicationDate":"1986","journal":"Biochemistry","firstPage":"3164","lastPage":"3171","volume":"25"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 781-1424 (ISOFORM 1)","VARIANTS ARG-852 AND ALA-1381"]},{"referenceNumber":14,"citation":{"id":"1988024","citationType":"journal article","authors":["Mancuso D.J.","Tuley E.A.","Westfield L.A.","Lester-Mancuso T.L.","Le Beau M.M.","Sorace J.M.","Sadler J.E."],"citationCrossReferences":[{"database":"PubMed","id":"1988024"},{"database":"DOI","id":"10.1021/bi00215a036"}],"title":"Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction.","publicationDate":"1991","journal":"Biochemistry","firstPage":"253","lastPage":"269","volume":"30"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 990-1947","VARIANTS ALA-1381 AND HIS-1472"]},{"referenceNumber":15,"citation":{"id":"9373253","citationType":"journal article","authors":["Schulte am Esch J. II","Cruz M.A.","Siegel J.B.","Anrather J.","Robson S.C."],"citationCrossReferences":[{"database":"PubMed","id":"9373253"},{"database":"DOI","id":"10.1182/blood.v90.11.4425"}],"title":"Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor.","publicationDate":"1997","journal":"Blood","firstPage":"4425","lastPage":"4437","volume":"90"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1236-1476 (ISOFORM 1)","VARIANT ALA-1381"]},{"referenceNumber":16,"citation":{"id":"3874428","citationType":"journal article","authors":["Ginsburg D.","Handin R.I.","Bonthron D.T.","Donlon T.A.","Bruns G.A.P.","Latt S.A.","Orkin S.H."],"citationCrossReferences":[{"database":"PubMed","id":"3874428"},{"database":"DOI","id":"10.1126/science.3874428"}],"title":"Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization.","publicationDate":"1985","journal":"Science","firstPage":"1401","lastPage":"1406","volume":"228"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 2621-2813 (ISOFORM 1)"]},{"referenceNumber":17,"citation":{"id":"3873280","citationType":"journal article","authors":["Lynch D.C.","Zimmerman T.S.","Collins C.J.","Brown M.","Morin M.J.","Ling E.H.","Livingston D.M."],"citationCrossReferences":[{"database":"PubMed","id":"3873280"},{"database":"DOI","id":"10.1016/0092-8674(85)90060-1"}],"title":"Molecular cloning of cDNA for human von Willebrand factor: authentication by a new method.","publicationDate":"1985","journal":"Cell","firstPage":"49","lastPage":"56","volume":"41"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 2731-2813 (ISOFORM 1)"]},{"referenceNumber":18,"citation":{"id":"CI-S6L163ED2Q10","citationType":"submission","authors":["Lynch D.C."],"publicationDate":"JUL-1991","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":19,"citation":{"id":"3875078","citationType":"journal article","authors":["Verweij C.L.","de Vries C.J.M.","Distel B.","van Zonneveld A.-J.","Geurts van Kessel A.","van Mourik J.A.","Pannekoek H."],"citationCrossReferences":[{"database":"PubMed","id":"3875078"},{"database":"DOI","id":"10.1093/nar/13.13.4699"}],"title":"Construction of cDNA coding for human von Willebrand factor using antibody probes for colony-screening and mapping of the chromosomal gene.","publicationDate":"1985","journal":"Nucleic Acids Res.","firstPage":"4699","lastPage":"4717","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 2731-2813 (ISOFORM 1)"]},{"referenceNumber":20,"citation":{"id":"3496594","citationType":"journal article","authors":["Collins C.J.","Underdahl J.P.","Levene R.B.","Ravera C.P.","Morin M.J.","Dombalagian M.J.","Ricca G.","Livingston D.M.","Lynch D.C."],"citationCrossReferences":[{"database":"PubMed","id":"3496594"},{"database":"DOI","id":"10.1073/pnas.84.13.4393"}],"title":"Molecular cloning of the human gene for von Willebrand factor and identification of the transcription initiation site.","publicationDate":"1987","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"4393","lastPage":"4397","volume":"84"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2731-2813"]},{"referenceNumber":21,"citation":{"id":"10961880","citationType":"journal article","authors":["Haberichter S.L.","Fahs S.A.","Montgomery R.R."],"citationCrossReferences":[{"database":"PubMed","id":"10961880"},{"database":"DOI","id":"10.1182/blood.v96.5.1808.h8001808_1808_1815"}],"title":"von Willebrand factor storage and multimerization: 2 independent intracellular processes.","publicationDate":"2000","journal":"Blood","firstPage":"1808","lastPage":"1815","volume":"96"},"referencePositions":["SUBUNIT","SUBCELLULAR LOCATION"]},{"referenceNumber":22,"citation":{"id":"3502076","citationType":"journal article","authors":["Marti T.","Rosselet S.J.","Titani K.","Walsh K.A."],"citationCrossReferences":[{"database":"PubMed","id":"3502076"},{"database":"DOI","id":"10.1021/bi00399a013"}],"title":"Identification of disulfide-bridged substructures within human von Willebrand factor.","publicationDate":"1987","journal":"Biochemistry","firstPage":"8099","lastPage":"8109","volume":"26"},"referencePositions":["DISULFIDE BONDS"]},{"referenceNumber":23,"citation":{"id":"3089784","citationType":"journal article","authors":["Samor B.","Michalski J.C.","Debray H.","Mazurier C.","Goudemand M.","van Halbeek H.","Vliegenthart J.F.G.","Montreuil J."],"citationCrossReferences":[{"database":"PubMed","id":"3089784"},{"database":"DOI","id":"10.1111/j.1432-1033.1986.tb09750.x"}],"title":"Primary structure of a new tetraantennary glycan of the N-acetyllactosaminic type isolated from human factor VIII/von Willebrand factor.","publicationDate":"1986","journal":"Eur. J. Biochem.","firstPage":"295","lastPage":"298","volume":"158"},"referencePositions":["STRUCTURE OF CARBOHYDRATES"]},{"referenceNumber":24,"citation":{"id":"9218428","citationType":"journal article","authors":["Saenko E.L.","Scandella D."],"citationCrossReferences":[{"database":"PubMed","id":"9218428"},{"database":"DOI","id":"10.1074/jbc.272.29.18007"}],"title":"The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von Willebrand factor.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"18007","lastPage":"18014","volume":"272"},"referencePositions":["INTERACTION WITH F8"]},{"referenceNumber":25,"citation":{"id":"14760718","citationType":"journal article","authors":["Bunkenborg J.","Pilch B.J.","Podtelejnikov A.V.","Wisniewski J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14760718"},{"database":"DOI","id":"10.1002/pmic.200300556"}],"title":"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.","publicationDate":"2004","journal":"Proteomics","firstPage":"454","lastPage":"465","volume":"4"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1515"],"referenceComments":[{"value":"Plasma","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2546"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":27,"citation":{"id":"19139490","citationType":"journal article","authors":["Jia W.","Lu Z.","Fu Y.","Wang H.P.","Wang L.H.","Chi H.","Yuan Z.F.","Zheng Z.B.","Song L.N.","Han H.H.","Liang Y.M.","Wang J.L.","Cai Y.","Zhang Y.K.","Deng Y.L.","Ying W.T.","He S.M.","Qian X.H."],"citationCrossReferences":[{"database":"PubMed","id":"19139490"},{"database":"DOI","id":"10.1074/mcp.m800504-mcp200"}],"title":"A strategy for precise and large scale identification of core fucosylated glycoproteins.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"913","lastPage":"923","volume":"8"},"referencePositions":["GLYCOSYLATION AT ASN-1515"]},{"referenceNumber":28,"citation":{"id":"9553097","citationType":"journal article","authors":["Emsley J.","Cruz M.","Handin R.","Liddington R."],"citationCrossReferences":[{"database":"PubMed","id":"9553097"},{"database":"DOI","id":"10.1074/jbc.273.17.10396"}],"title":"Crystal structure of the von Willebrand factor A1 domain and implications for the binding of platelet glycoprotein Ib.","publicationDate":"1998","journal":"J. Biol. Chem.","firstPage":"10396","lastPage":"10401","volume":"273"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1261-1468"]},{"referenceNumber":29,"citation":{"id":"9331419","citationType":"journal article","authors":["Huizinga E.G.","Martijn van der Plas R.","Kroon J.","Sixma J.J.","Gros P."],"citationCrossReferences":[{"database":"PubMed","id":"9331419"},{"database":"DOI","id":"10.1016/s0969-2126(97)00266-9"}],"title":"Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding.","publicationDate":"1997","journal":"Structure","firstPage":"1147","lastPage":"1156","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1685-1873"]},{"referenceNumber":30,"citation":{"id":"9312128","citationType":"journal article","authors":["Bienkowska J.","Cruz M.","Atiemo A.","Handin R.","Liddington R."],"citationCrossReferences":[{"database":"PubMed","id":"9312128"},{"database":"DOI","id":"10.1074/jbc.272.40.25162"}],"title":"The von Willebrand factor A3 domain does not contain a metal ion-dependent adhesion site motif.","publicationDate":"1997","journal":"J. Biol. Chem.","firstPage":"25162","lastPage":"25167","volume":"272"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1686-1872"]},{"referenceNumber":31,"citation":{"id":"12871266","citationType":"journal article","authors":["Ruggeri Z.M."],"citationCrossReferences":[{"database":"PubMed","id":"12871266"},{"database":"DOI","id":"10.1046/j.1538-7836.2003.00260.x"}],"title":"von Willebrand factor, platelets and endothelial cell interactions.","publicationDate":"2003","journal":"J. Thromb. Haemost.","firstPage":"1335","lastPage":"1342","volume":"1"},"referencePositions":["REVIEW"]},{"referenceNumber":32,"citation":{"id":"2786201","citationType":"journal article","authors":["Ginsburg D.","Konkle B.A.","Gill J.C.","Montgomery R.R.","Bockenstedt P.L.","Johnson T.A.","Yang A.Y."],"citationCrossReferences":[{"database":"PubMed","id":"2786201"},{"database":"DOI","id":"10.1073/pnas.86.10.3723"}],"title":"Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.","publicationDate":"1989","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"3723","lastPage":"3727","volume":"86"},"referencePositions":["VARIANTS VWD2 TRP-1597 AND ASP-1607"]},{"referenceNumber":33,"citation":{"id":"1673047","citationType":"journal article","authors":["Iannuzzi M.C.","Hidaka N.","Boehnke M.","Bruck M.E.","Hanna W.T.","Collins F.S.","Ginsburg D."],"citationCrossReferences":[{"database":"PubMed","id":"1673047"}],"title":"Analysis of the relationship of von Willebrand disease (vWD) and hereditary hemorrhagic telangiectasia and identification of a potential type IIA vWD mutation (IIe865 to Thr).","publicationDate":"1991","journal":"Am. J. Hum. Genet.","firstPage":"757","lastPage":"763","volume":"48"},"referencePositions":["VARIANT VWD2 THR-1628"]},{"referenceNumber":34,"citation":{"id":"1832934","citationType":"journal article","authors":["Gaucher C.","Mercier B.","Jorieux S.","Oufkir D.","Mazurier C."],"citationCrossReferences":[{"database":"PubMed","id":"1832934"},{"database":"DOI","id":"10.1111/j.1365-2141.1991.tb04480.x"}],"title":"Identification of two point mutations in the von Willebrand factor gene of three families with the 'Normandy' variant of von Willebrand disease.","publicationDate":"1991","journal":"Br. J. Haematol.","firstPage":"506","lastPage":"514","volume":"78"},"referencePositions":["VARIANTS VWD2 TRP-816 AND GLN-854"]},{"referenceNumber":35,"citation":{"id":"1761120","citationType":"journal article","authors":["Donner M.","Andersson A.-M.","Kristoffersson A.-C.","Nilsson I.M.","Dahlback B.","Holmberg L."],"citationCrossReferences":[{"database":"PubMed","id":"1761120"},{"database":"DOI","id":"10.1111/j.1600-0609.1991.tb01858.x"}],"title":"An Arg545-->Cys545 substitution mutation of the von Willebrand factor in type IIB von Willebrand's disease.","publicationDate":"1991","journal":"Eur. J. Haematol.","firstPage":"342","lastPage":"345","volume":"47"},"referencePositions":["VARIANT VWD2 CYS-1308"]},{"referenceNumber":36,"citation":{"id":"2010538","citationType":"journal article","authors":["Randi A.M.","Rabinowitz I.","Mancuso D.J.","Mannucci P.M.","Sadler J.E."],"citationCrossReferences":[{"database":"PubMed","id":"2010538"},{"database":"DOI","id":"10.1172/jci115122"}],"title":"Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences.","publicationDate":"1991","journal":"J. Clin. Invest.","firstPage":"1220","lastPage":"1226","volume":"87"},"referencePositions":["VARIANTS VWD2 TRP-1306; CYS-1308 AND PRO-1613"]},{"referenceNumber":37,"citation":{"id":"1672694","citationType":"journal article","authors":["Cooney K.A.","Nichols W.C.","Bruck M.E.","Bahou W.F.","Shapiro A.D.","Bowie E.J.W.","Gralnick H.R.","Ginsburg D."],"citationCrossReferences":[{"database":"PubMed","id":"1672694"},{"database":"DOI","id":"10.1172/jci115123"}],"title":"The molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domain.","publicationDate":"1991","journal":"J. Clin. Invest.","firstPage":"1227","lastPage":"1233","volume":"87"},"referencePositions":["VARIANTS VWD2 TRP-1306; CYS-1308; MET-1316 AND GLN-1341","VARIANT HIS-1399"]},{"referenceNumber":38,"citation":{"id":"2011604","citationType":"journal article","authors":["Ware J.","Dent J.A.","Azuma H.","Sugimoto M.","Kyrle P.A.","Yoshioka A.","Ruggeri Z.M."],"citationCrossReferences":[{"database":"PubMed","id":"2011604"},{"database":"DOI","id":"10.1073/pnas.88.7.2946"}],"title":"Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor.","publicationDate":"1991","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2946","lastPage":"2950","volume":"88"},"referencePositions":["VARIANT VWD2 CYS-1313"]},{"referenceNumber":39,"citation":{"id":"1906179","citationType":"journal article","authors":["Tuley E.A.","Gaucher C.","Jorieux S.","Worrall N.K.","Sadler J.E.","Mazurier C."],"citationCrossReferences":[{"database":"PubMed","id":"1906179"},{"database":"DOI","id":"10.1073/pnas.88.14.6377"}],"title":"Expression of von Willebrand factor 'Normandy': an autosomal mutation that mimics hemophilia A.","publicationDate":"1991","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6377","lastPage":"6381","volume":"88"},"referencePositions":["VARIANT VWD2 MET-791"]},{"referenceNumber":40,"citation":{"id":"1729889","citationType":"journal article","authors":["Murray E.W.","Giles A.R.","Lillicrap D."],"citationCrossReferences":[{"database":"PubMed","id":"1729889"}],"title":"Germ-line mosaicism for a valine-to-methionine substitution at residue 553 in the glycoprotein Ib-binding domain of von Willebrand factor, causing type IIB von Willebrand disease.","publicationDate":"1992","journal":"Am. J. Hum. Genet.","firstPage":"199","lastPage":"207","volume":"50"},"referencePositions":["VARIANT VWD2 MET-1316"]},{"referenceNumber":41,"citation":{"id":"1420817","citationType":"journal article","authors":["Pietu G.","Ribba A.S.","de Paillette L.","Cherel G.","Lavergne J.-M.","Bahnak B.R.","Meyer D."],"citationCrossReferences":[{"database":"PubMed","id":"1420817"},{"database":"DOI","id":"10.1097/00001721-199203040-00008"}],"title":"Molecular study of von Willebrand disease: identification of potential mutations in patients with type IIA and type IIB.","publicationDate":"1992","journal":"Blood Coagul. Fibrinolysis","firstPage":"415","lastPage":"421","volume":"3"},"referencePositions":["VARIANTS VWD2 TRP-1306; MET-1316; THR-1628 AND SER-1648"]},{"referenceNumber":42,"citation":{"id":"1419803","citationType":"journal article","authors":["Donner M.","Kristoffersson A.-C.","Lenk H.","Scheibel E.","Dahlback B.","Nilsson I.M.","Holmberg L."],"citationCrossReferences":[{"database":"PubMed","id":"1419803"},{"database":"DOI","id":"10.1111/j.1365-2141.1992.tb04594.x"}],"title":"Type IIB von Willebrand's disease: gene mutations and clinical presentation in nine families from Denmark, Germany and Sweden.","publicationDate":"1992","journal":"Br. J. Haematol.","firstPage":"58","lastPage":"65","volume":"82"},"referencePositions":["VARIANTS VWD2 TRP-1306; CYS-1308; LEU-1314 AND LEU-1318"]},{"referenceNumber":43,"citation":{"id":"1419804","citationType":"journal article","authors":["Lavergne J.-M.","de Paillette L.","Bahnak B.R.","Ribba A.-S.","Fressinaud E.","Meyer D.","Pietu G."],"citationCrossReferences":[{"database":"PubMed","id":"1419804"},{"database":"DOI","id":"10.1111/j.1365-2141.1992.tb04595.x"}],"title":"Defects in type IIA von Willebrand disease: a cysteine 509 to arginine substitution in the mature von Willebrand factor disrupts a disulphide loop involved in the interaction with platelet glycoprotein Ib-IX.","publicationDate":"1992","journal":"Br. J. Haematol.","firstPage":"66","lastPage":"72","volume":"82"},"referencePositions":["VARIANT VWD2 ARG-1272"]},{"referenceNumber":44,"citation":{"id":"1429668","citationType":"journal article","authors":["Ribba A.S.","Voorberg J.","Meyer D.","Pannekoek H.","Pietu G."],"citationCrossReferences":[{"database":"PubMed","id":"1429668"},{"database":"DOI","id":"10.1016/s0021-9258(18)50078-8"}],"title":"Characterization of recombinant von Willebrand factor corresponding to mutations in type IIA and type IIB von Willebrand disease.","publicationDate":"1992","journal":"J. Biol. Chem.","firstPage":"23209","lastPage":"23215","volume":"267"},"referencePositions":["VARIANT VWD2 LYS-1638"]},{"referenceNumber":45,"citation":{"id":"1409710","citationType":"journal article","authors":["Rabinowitz I.","Tuley E.A.","Mancuso D.J.","Randi A.M.","Firkin B.G.","Howard M.A.","Sadler J.E."],"citationCrossReferences":[{"database":"PubMed","id":"1409710"},{"database":"DOI","id":"10.1073/pnas.89.20.9846"}],"title":"von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9846","lastPage":"9849","volume":"89"},"referencePositions":["VARIANT VWD2 SER-1324"]},{"referenceNumber":46,"citation":{"id":"8338947","citationType":"journal article","authors":["Inbal A.","Englender T.","Kornbrot N.","Randi A.M.","Castaman G.","Mannucci P.M.","Sadler J.E."],"citationCrossReferences":[{"database":"PubMed","id":"8338947"},{"database":"DOI","id":"10.1182/blood.v82.3.830.830"}],"title":"Identification of three candidate mutations causing type IIA von Willebrand disease using a rapid, nonradioactive, allele-specific hybridization method.","publicationDate":"1993","journal":"Blood","firstPage":"830","lastPage":"836","volume":"82"},"referencePositions":["VARIANTS VWD2 GLN-1597; ARG-1609 AND GLU-1665"]},{"referenceNumber":47,"citation":{"id":"8435341","citationType":"journal article","authors":["Gaucher C.","Hanss M.","Dechavanne M.","Mazurier C."],"citationCrossReferences":[{"database":"PubMed","id":"8435341"},{"database":"DOI","id":"10.1111/j.1365-2141.1993.tb04637.x"}],"title":"Substitution of cysteine for phenylalanine 751 in mature von Willebrand factor is a novel candidate mutation in a family with type IIA von Willebrand disease.","publicationDate":"1993","journal":"Br. J. Haematol.","firstPage":"94","lastPage":"99","volume":"83"},"referencePositions":["VARIANT VWD2 CYS-1514"]},{"referenceNumber":48,"citation":{"id":"8348943","citationType":"journal article","authors":["Donner M.","Kristoffersson A.C.","Berntorp E.","Scheibel E.","Thorsen S.","Dahlback B.","Nilsson I.M.","Holmberg L."],"citationCrossReferences":[{"database":"PubMed","id":"8348943"},{"database":"DOI","id":"10.1111/j.1600-0609.1993.tb00602.x"}],"title":"Two new candidate mutations in type IIA von Willebrand's disease (Arg834-->Gly, Gly846-->Arg) and one polymorphism (Tyr821-->Cys) in the A2 region of the von Willebrand factor.","publicationDate":"1993","journal":"Eur. J. Haematol.","firstPage":"38","lastPage":"44","volume":"51"},"referencePositions":["VARIANTS VWD2 GLY-1597 AND ARG-1609","VARIANT CYS-1584"]},{"referenceNumber":49,"citation":{"id":"8376405","citationType":"journal article","authors":["Rabinowitz I.","Randi A.M.","Shindler K.S.","Tuley E.A.","Rustagi P.K.","Sadler J.E."],"citationCrossReferences":[{"database":"PubMed","id":"8376405"},{"database":"DOI","id":"10.1016/s0021-9258(20)80753-4"}],"title":"Type IIB mutation His-505-->Asp implicates a new segment in the control of von Willebrand factor binding to platelet glycoprotein Ib.","publicationDate":"1993","journal":"J. Biol. Chem.","firstPage":"20497","lastPage":"20501","volume":"268"},"referencePositions":["VARIANT VWD2 ASP-1268"]},{"referenceNumber":50,"citation":{"id":"8486782","citationType":"journal article","authors":["Holmberg L.","Dent J.A.","Schneppenheim R.","Budde U.","Ware J.","Ruggeri Z.M."],"citationCrossReferences":[{"database":"PubMed","id":"8486782"},{"database":"DOI","id":"10.1172/jci116443"}],"title":"von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.","publicationDate":"1993","journal":"J. Clin. Invest.","firstPage":"2169","lastPage":"2177","volume":"91"},"referencePositions":["VARIANT VWD2 LEU-1266"]},{"referenceNumber":51,"citation":{"id":"8123843","citationType":"journal article","authors":["Hilbert L.","Gaucher C.","de Romeuf C.","Horellou M.H.","Vink T.","Mazurier C."],"citationCrossReferences":[{"database":"PubMed","id":"8123843"},{"database":"DOI","id":"10.1182/blood.v83.6.1542.1542"}],"title":"Leu 697-->Val mutation in mature von Willebrand factor is responsible for type IIB von Willebrand disease.","publicationDate":"1994","journal":"Blood","firstPage":"1542","lastPage":"1550","volume":"83"},"referencePositions":["VARIANT VWD2 VAL-1460"]},{"referenceNumber":52,"citation":{"id":"8123844","citationType":"journal article","authors":["Lyons S.E.","Cooney K.A.","Bockenstedt P.","Ginsburg D."],"citationCrossReferences":[{"database":"PubMed","id":"8123844"},{"database":"DOI","id":"10.1182/blood.v83.6.1551.1551"}],"title":"Characterization of Leu777Pro and Ile865Thr type IIA von Willebrand disease mutations.","publicationDate":"1994","journal":"Blood","firstPage":"1551","lastPage":"1557","volume":"83"},"referencePositions":["VARIANTS VWD2 PRO-1540 AND THR-1628"]},{"referenceNumber":53,"citation":{"id":"8088787","citationType":"journal article","authors":["Zhang Z.P.","Blombaeck M.","Egberg N.","Falk G.","Anvret M."],"citationCrossReferences":[{"database":"PubMed","id":"8088787"},{"database":"DOI","id":"10.1006/geno.1994.1241"}],"title":"Characterization of the von Willebrand factor gene (VWF) in von Willebrand disease type III patients from 24 families of Swedish and Finnish origin.","publicationDate":"1994","journal":"Genomics","firstPage":"188","lastPage":"193","volume":"21"},"referencePositions":["VARIANT VWD3 TYR-2739"]},{"referenceNumber":54,"citation":{"id":"7989040","citationType":"journal article","authors":["Schneppenheim R.","Krey S.","Bergmann F.","Bock D.","Budde U.","Lange M.","Linde R.","Mittler U.","Meili E.","Mertes G.","Olek K.","Plendl H.","Simeoni E."],"citationCrossReferences":[{"database":"PubMed","id":"7989040"},{"database":"DOI","id":"10.1007/bf00206958"}],"title":"Genetic heterogeneity of severe von Willebrand disease type III in the German population.","publicationDate":"1994","journal":"Hum. Genet.","firstPage":"640","lastPage":"652","volume":"94"},"referencePositions":["VARIANT VWD3 CYS-377"]},{"referenceNumber":55,"citation":{"id":"8011991","citationType":"journal article","authors":["Uno H.","Nishida N.","Ishizaki J.","Suzuki M.","Nishikubo T.","Miyata S.","Takahashi Y.","Yoshioka A.","Tsuda K."],"citationCrossReferences":[{"database":"PubMed","id":"8011991"}],"title":"Investigation of type IIC von Willebrand disease.","publicationDate":"1994","journal":"Int. J. Hematol.","firstPage":"219","lastPage":"225","volume":"59"},"referencePositions":["VARIANT VWD2 SER-528"]},{"referenceNumber":56,"citation":{"id":"7620154","citationType":"journal article","authors":["Hilbert L.","Gaucher C.","Mazurier C."],"citationCrossReferences":[{"database":"PubMed","id":"7620154"},{"database":"DOI","id":"10.1182/blood.v86.3.1010.1010"}],"title":"Identification of two mutations (Arg611Cys and Arg611His) in the A1 loop of von Willebrand factor (vWF) responsible for type 2 von Willebrand disease with decreased platelet-dependent function of vWF.","publicationDate":"1995","journal":"Blood","firstPage":"1010","lastPage":"1018","volume":"86"},"referencePositions":["VARIANTS VWD2 CYS-1374 AND HIS-1374"]},{"referenceNumber":57,"citation":{"id":"7734373","citationType":"journal article","authors":["Castaman G.","Eikenboom C.J.C.","Rodeghiero F.","Briet K.","Reitsma P.H."],"citationCrossReferences":[{"database":"PubMed","id":"7734373"},{"database":"DOI","id":"10.1111/j.1365-2141.1995.tb08383.x"}],"title":"A novel candidate mutation (Arg611-->His) in type I 'platelet discordant' von Willebrand's disease with desmopressin-induced thrombocytopenia.","publicationDate":"1995","journal":"Br. J. Haematol.","firstPage":"656","lastPage":"658","volume":"89"},"referencePositions":["VARIANT VWD2 HIS-1374"]},{"referenceNumber":58,"citation":{"id":"8547152","citationType":"journal article","authors":["Hilbert L.","Gaucher C.","Mazurier C."],"citationCrossReferences":[{"database":"PubMed","id":"8547152"},{"database":"DOI","id":"10.1111/j.1365-2141.1995.tb05423.x"}],"title":"Effects of different amino-acid substitutions in the leucine 694-proline 708 segment of recombinant von Willebrand factor.","publicationDate":"1995","journal":"Br. J. Haematol.","firstPage":"983","lastPage":"990","volume":"91"},"referencePositions":["VARIANT VWD2 VAL-1461"]},{"referenceNumber":59,"citation":{"id":"7789955","citationType":"journal article","authors":["Schneppenheim R.","Thomas K.B.","Krey S.","Budde U.","Jessat U.","Sutor A.H.","Zeiger B."],"citationCrossReferences":[{"database":"PubMed","id":"7789955"},{"database":"DOI","id":"10.1007/bf00209487"}],"title":"Identification of a candidate missense mutation in a family with von Willebrand disease type IIC.","publicationDate":"1995","journal":"Hum. Genet.","firstPage":"681","lastPage":"686","volume":"95"},"referencePositions":["VARIANT VWD2 ARG-550"]},{"referenceNumber":60,"citation":{"id":"8622978","citationType":"journal article","authors":["Schneppenheim R.","Brassard J.","Krey S.","Budde U.","Kunicki T.J.","Holmberg L.","Ware J.","Ruggeri Z.M."],"citationCrossReferences":[{"database":"PubMed","id":"8622978"},{"database":"DOI","id":"10.1073/pnas.93.8.3581"}],"title":"Defective dimerization of von Willebrand factor subunits due to a Cys-> Arg mutation in type IID von Willebrand disease.","publicationDate":"1996","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"3581","lastPage":"3586","volume":"93"},"referencePositions":["VARIANT VWD2 ARG-2773"]},{"referenceNumber":61,"citation":{"id":"10887119","citationType":"journal article","authors":["Allen S.","Abuzenadah A.M.","Hinks J.","Blagg J.L.","Gursel T.","Ingerslev J.","Goodeve A.C.","Peake I.R.","Daly M.E."],"citationCrossReferences":[{"database":"PubMed","id":"10887119"},{"database":"DOI","id":"10.1182/blood.v96.2.560"}],"title":"A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion.","publicationDate":"2000","journal":"Blood","firstPage":"560","lastPage":"568","volume":"96"},"referencePositions":["VARIANT VWD1 TRP-273","VARIANT VWD3 TRP-273"]},{"referenceNumber":62,"citation":{"id":"11698279","citationType":"journal article","authors":["Bodo I.","Katsumi A.","Tuley E.A.","Eikenboom J.C.","Dong Z.","Sadler J.E."],"citationCrossReferences":[{"database":"PubMed","id":"11698279"},{"database":"DOI","id":"10.1182/blood.v98.10.2973"}],"title":"Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular retention and degradation of heterodimers: a possible general mechanism for dominant mutations of oligomeric proteins.","publicationDate":"2001","journal":"Blood","firstPage":"2973","lastPage":"2979","volume":"98"},"referencePositions":["VARIANT VWD1 ARG-1149","MUTAGENESIS OF CYS-1149 AND CYS-1169"]},{"referenceNumber":63,"citation":{"id":"12406074","citationType":"journal article","authors":["Mazurier C.","Parquet-Gernez A.","Gaucher C.","Lavergne J.-M.","Goudemand J."],"citationCrossReferences":[{"database":"PubMed","id":"12406074"},{"database":"DOI","id":"10.1046/j.1365-2141.2002.03819.x"}],"title":"Factor VIII deficiency not induced by FVIII gene mutation in a female first cousin of two brothers with haemophilia A.","publicationDate":"2002","journal":"Br. J. Haematol.","firstPage":"390","lastPage":"392","volume":"119"},"referencePositions":["VARIANT VWD2 ARG-1060"]},{"referenceNumber":64,"citation":{"id":"15755288","citationType":"journal article","authors":["Bowen D.J.","Collins P.W.","Lester W.","Cumming A.M.","Keeney S.","Grundy P.","Enayat S.M.","Bolton-Maggs P.H.","Keeling D.M.","Khair K.","Tait R.C.","Wilde J.T.","Pasi K.J.","Hill F.G."],"citationCrossReferences":[{"database":"PubMed","id":"15755288"},{"database":"DOI","id":"10.1111/j.1365-2141.2005.05375.x"}],"title":"The prevalence of the cysteine1584 variant of von Willebrand factor is increased in type 1 von Willebrand disease: co-segregation with increased susceptibility to ADAMTS13 proteolysis but not clinical phenotype.","publicationDate":"2005","journal":"Br. J. Haematol.","firstPage":"830","lastPage":"836","volume":"128"},"referencePositions":["VARIANT CYS-1584"]},{"referenceNumber":65,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] CYS-1570"]},{"referenceNumber":66,"citation":{"id":"17190853","citationType":"journal article","authors":["James P.D.","Notley C.","Hegadorn C.","Leggo J.","Tuttle A.","Tinlin S.","Brown C.","Andrews C.","Labelle A.","Chirinian Y.","O'Brien L.","Othman M.","Rivard G.","Rapson D.","Hough C.","Lillicrap D."],"citationCrossReferences":[{"database":"PubMed","id":"17190853"},{"database":"DOI","id":"10.1182/blood-2006-05-021105."}],"title":"The mutational spectrum of type 1 von Willebrand disease: Results from a Canadian cohort study.","publicationDate":"2007","journal":"Blood","firstPage":"145","lastPage":"154","volume":"109"},"referencePositions":["VARIANT VWD3 SER-2063"]},{"referenceNumber":67,"citation":{"id":"21592258","citationType":"journal article","authors":["Woods A.I.","Sanchez-Luceros A.","Kempfer A.C.","Powazniak Y.","Calderazzo Pereyra J.C.","Blanco A.N.","Meschengieser S.S.","Lazzari M.A."],"citationCrossReferences":[{"database":"PubMed","id":"21592258"},{"database":"DOI","id":"10.1111/j.1365-2516.2011.02569.x"}],"title":"C1272F: a novel type 2A von Willebrand's disease mutation in A1 domain; its clinical significance.","publicationDate":"2012","journal":"Haemophilia","firstPage":"112","lastPage":"116","volume":"18"},"referencePositions":["VARIANT VWD2 PHE-1272"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X04385","properties":[{"key":"ProteinId","value":"CAA27972.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M25865","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25828","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25829","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25830","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25831","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25832","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25833","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25834","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25835","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25836","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25837","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25838","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25839","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25840","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25841","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25842","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25843","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25844","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25845","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25846","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25847","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25848","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25849","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25850","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25851","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25852","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25853","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25854","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25855","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25856","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25857","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25858","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25859","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25860","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25861","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25862","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25863","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M25864","properties":[{"key":"ProteinId","value":"AAB59458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC005845","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC005846","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC005904","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471116","properties":[{"key":"ProteinId","value":"EAW88817.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC022258","properties":[{"key":"ProteinId","value":"AAH22258.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X04146","properties":[{"key":"ProteinId","value":"CAA27765.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X06828","properties":[{"key":"ProteinId","value":"CAA29985.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X06829","properties":[{"key":"ProteinId","value":"CAA29985.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M17588","properties":[{"key":"ProteinId","value":"AAA65940.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M10321","properties":[{"key":"ProteinId","value":"AAB59512.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M60675","properties":[{"key":"ProteinId","value":"AAA61295.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"U81237","properties":[{"key":"ProteinId","value":"AAB39987.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"K03028","properties":[{"key":"ProteinId","value":"AAA61293.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X02672","properties":[{"key":"ProteinId","value":"CAA26503.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M16946","properties":[{"key":"ProteinId","value":"AAA61294.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"M16945","properties":[{"key":"ProteinId","value":"AAA61294.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS8539.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P04275-1"},{"database":"PIR","id":"A34480","properties":[{"key":"EntryName","value":"VWHU"}]},{"database":"RefSeq","id":"NP_000543.3","properties":[{"key":"NucleotideSequenceId","value":"NM_000552.5"}],"isoformId":"P04275-1"},{"database":"RefSeq","id":"NP_001432436.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001445507.1"}],"isoformId":"P04275-1"},{"database":"PDB","id":"1AO3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B=1686-1872"}]},{"database":"PDB","id":"1ATZ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=1685-1873"}]},{"database":"PDB","id":"1AUQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.30 A"},{"key":"Chains","value":"A=1261-1468"}]},{"database":"PDB","id":"1FE8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A/B/C=1683-1874"}]},{"database":"PDB","id":"1FNS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1271-1465"}]},{"database":"PDB","id":"1IJB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=1263-1464"}]},{"database":"PDB","id":"1IJK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=1263-1464"}]},{"database":"PDB","id":"1M10","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=1261-1468"}]},{"database":"PDB","id":"1OAK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A=1270-1465"}]},{"database":"PDB","id":"1SQ0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=1259-1471"}]},{"database":"PDB","id":"1U0N","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.95 A"},{"key":"Chains","value":"A=1261-1468"}]},{"database":"PDB","id":"1UEX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"C=1260-1468"}]},{"database":"PDB","id":"2ADF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1683-1874"}]},{"database":"PDB","id":"2MHP","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=766-864"}]},{"database":"PDB","id":"2MHQ","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=766-864"}]},{"database":"PDB","id":"3GXB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=1495-1671"}]},{"database":"PDB","id":"3HXO","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A=1260-1468"}]},{"database":"PDB","id":"3HXQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.69 A"},{"key":"Chains","value":"A=1260-1468"}]},{"database":"PDB","id":"3PPV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1488-1674"}]},{"database":"PDB","id":"3PPW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A=1488-1674"}]},{"database":"PDB","id":"3PPX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.91 A"},{"key":"Chains","value":"A=1488-1674"}]},{"database":"PDB","id":"3PPY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1488-1674"}]},{"database":"PDB","id":"3ZQK","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B/C=1477-1674"}]},{"database":"PDB","id":"4C29","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B=1264-1471"}]},{"database":"PDB","id":"4C2A","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.08 A"},{"key":"Chains","value":"A=1264-1471"}]},{"database":"PDB","id":"4C2B","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"A/C/E/G=1264-1471"}]},{"database":"PDB","id":"4DMU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"B/D/F/H/J/L=1683-1874"}]},{"database":"PDB","id":"4NT5","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.28 A"},{"key":"Chains","value":"A=2721-2813"}]},{"database":"PDB","id":"5BV8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A=1238-1471"}]},{"database":"PDB","id":"6FWN","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2497-2577"}]},{"database":"PDB","id":"6N29","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=764-1244"}]},{"database":"PDB","id":"7EOW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1261-1468"}]},{"database":"PDB","id":"7F49","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.09 A"},{"key":"Chains","value":"A=1259-1468"}]},{"database":"PDB","id":"7KWO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"V=1-1253"}]},{"database":"PDB","id":"7P4N","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"A=2647-2720"}]},{"database":"PDB","id":"7PMV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"A/B/D/E=1-1241"}]},{"database":"PDB","id":"7PNF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.35 A"},{"key":"Chains","value":"B/D=1-1241"}]},{"database":"PDB","id":"7WN3","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.29 A"},{"key":"Chains","value":"A/B/E/G=23-763, C/D/F/H=764-1241"}]},{"database":"PDB","id":"7WN4","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"E/G=23-763, F/H=764-1241"}]},{"database":"PDB","id":"7WN6","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.29 A"},{"key":"Chains","value":"A/B/E/G=23-763, C/D/F/H=764-1241"}]},{"database":"PDB","id":"7WPP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"E/G=23-763, F/H=764-1241"}]},{"database":"PDB","id":"7WPQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.27 A"},{"key":"Chains","value":"A/B/E/G=23-763, C/D/F/H=764-1241"}]},{"database":"PDB","id":"7WPR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.39 A"},{"key":"Chains","value":"A/B/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=23-763, C/D/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f=764-1241"}]},{"database":"PDB","id":"7WPS","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.32 A"},{"key":"Chains","value":"A/B/E/G/I/K/M/O/Q/S/U/W/Y/a=23-763, C/D/F/H/J/L/N/P/R/T/V/X/Z/b=764-1241"}]},{"database":"PDB","id":"7WQT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.30 A"},{"key":"Chains","value":"A/B/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=23-763, C/D/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f=764-1241"}]},{"database":"PDB","id":"7ZWH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"D/E=1-1197, G/H=1265-1463"}]},{"database":"PDB","id":"8D3C","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=1-1464"}]},{"database":"PDB","id":"8D3D","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=1-1464"}]},{"database":"PDBsum","id":"1AO3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1ATZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1AUQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FE8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1FNS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1IJB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1IJK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1M10","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1OAK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1SQ0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1U0N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"1UEX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2ADF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MHP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2MHQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3GXB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HXO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3HXQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3PPV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3PPW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3PPX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3PPY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3ZQK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4C29","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4C2A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4C2B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DMU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NT5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5BV8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6FWN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6N29","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7EOW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7F49","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7KWO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7P4N","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7PMV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7PNF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WN3","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WN4","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WN6","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WPP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WPQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WPR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WPS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WQT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7ZWH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8D3C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8D3D","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13541","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13547","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-14998","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-23057","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27156","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27157","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-27158","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32620","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32621","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32622","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32687","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32688","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32689","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32690","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32713","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"SASBDB","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"113289","properties":[{"key":"Interactions","value":"37"}]},{"database":"CORUM","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-29667N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P04275","properties":[{"key":"Number of interactors","value":"601"}]},{"database":"IntAct","id":"P04275","properties":[{"key":"Interactions","value":"65"}]},{"database":"MINT","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-VWF","properties":[{"key":"Evidences","value":"8 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000261405","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL2021748","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB09329","properties":[{"key":"GenericName","value":"Antihemophilic factor (recombinant), PEGylated"}]},{"database":"DrugBank","id":"DB00025","properties":[{"key":"GenericName","value":"Antihemophilic factor, human recombinant"}]},{"database":"DrugBank","id":"DB15164","properties":[{"key":"GenericName","value":"Apadamtase alfa"}]},{"database":"DrugBank","id":"DB06081","properties":[{"key":"GenericName","value":"Caplacizumab"}]},{"database":"DrugBank","id":"DB11607","properties":[{"key":"GenericName","value":"Efmoroctocog alfa"}]},{"database":"DrugBank","id":"DB05202","properties":[{"key":"GenericName","value":"Egaptivon pegol"}]},{"database":"DrugBank","id":"DB13998","properties":[{"key":"GenericName","value":"Lonoctocog alfa"}]},{"database":"DrugBank","id":"DB21360","properties":[{"key":"GenericName","value":"Mitoflaxone"}]},{"database":"DrugBank","id":"DB13999","properties":[{"key":"GenericName","value":"Moroctocog alfa"}]},{"database":"DrugBank","id":"DB16007","properties":[{"key":"GenericName","value":"Rurioctocog alfa pegol"}]},{"database":"DrugBank","id":"DB09108","properties":[{"key":"GenericName","value":"Simoctocog alfa"}]},{"database":"DrugBank","id":"DB11606","properties":[{"key":"GenericName","value":"Susoctocog alfa"}]},{"database":"DrugBank","id":"DB14738","properties":[{"key":"GenericName","value":"Turoctocog alfa pegol"}]},{"database":"DrugCentral","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"I08.950","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"I08.954","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P04275","properties":[{"key":"glycosylation","value":"72 N-Linked glycans (12 sites), 2 O-Linked glycans"}]},{"database":"GlyCosmos","id":"P04275","properties":[{"key":"glycosylation","value":"28 sites, 120 glycans"}]},{"database":"GlyGen","id":"P04275","properties":[{"key":"glycosylation","value":"31 sites, 193 N-linked glycans (15 sites), 10 O-linked glycans (8 sites)"}]},{"database":"iPTMnet","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"VWF","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"317373549","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000261405","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"51696","properties":[{"key":"Description","value":"-"}],"isoformId":"P04275-1"},{"database":"ProteomicsDB","id":"74127","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P04275","properties":[{"key":"antibodies","value":"59 sequenced antibodies"}]},{"database":"Antibodypedia","id":"789","properties":[{"key":"antibodies","value":"2193 antibodies from 56 providers"}]},{"database":"DNASU","id":"7450","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000261405.10","properties":[{"key":"ProteinId","value":"ENSP00000261405.5"},{"key":"GeneId","value":"ENSG00000110799.15"}],"isoformId":"P04275-1"},{"database":"Ensembl","id":"ENST00000895679.1","properties":[{"key":"ProteinId","value":"ENSP00000565738.1"},{"key":"GeneId","value":"ENSG00000110799.15"}],"isoformId":"P04275-1"},{"database":"GeneID","id":"7450","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:7450","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000261405.10","properties":[{"key":"ProteinId","value":"ENSP00000261405.5"},{"key":"RefSeqNucleotideId","value":"NM_000552.5"},{"key":"RefSeqProteinId","value":"NP_000543.3"}]},{"database":"UCSC","id":"uc001qnn.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P04275-1"},{"database":"AGR","id":"HGNC:12726","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA37337","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7450","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"7450","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"VWF","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"VWF","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:12726","properties":[{"key":"GeneName","value":"VWF"}]},{"database":"HPA","id":"ENSG00000110799","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"VWF","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"193400","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"277480","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"613160","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"613554","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000110799","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"166078","properties":[{"key":"Disease","value":"Von Willebrand disease type 1"}]},{"database":"Orphanet","id":"166084","properties":[{"key":"Disease","value":"Von Willebrand disease type 2A"}]},{"database":"Orphanet","id":"166087","properties":[{"key":"Disease","value":"Von Willebrand disease type 2B"}]},{"database":"Orphanet","id":"166090","properties":[{"key":"Disease","value":"Von Willebrand disease type 2M"}]},{"database":"Orphanet","id":"166093","properties":[{"key":"Disease","value":"Von Willebrand disease type 2N"}]},{"database":"Orphanet","id":"166096","properties":[{"key":"Disease","value":"Von Willebrand disease type 3"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000110799","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1216","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155810","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000076_5_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KFEACHH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6262482at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P04275","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:ENSG00000110799-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-114608","properties":[{"key":"PathwayName","value":"Platelet degranulation"}]},{"database":"Reactome","id":"R-HSA-216083","properties":[{"key":"PathwayName","value":"Integrin cell surface interactions"}]},{"database":"Reactome","id":"R-HSA-354192","properties":[{"key":"PathwayName","value":"Integrin signaling"}]},{"database":"Reactome","id":"R-HSA-354194","properties":[{"key":"PathwayName","value":"GRB2:SOS provides linkage to MAPK signaling for Integrins"}]},{"database":"Reactome","id":"R-HSA-372708","properties":[{"key":"PathwayName","value":"p130Cas linkage to MAPK signaling for integrins"}]},{"database":"Reactome","id":"R-HSA-430116","properties":[{"key":"PathwayName","value":"GP1b-IX-V activation signalling"}]},{"database":"Reactome","id":"R-HSA-5674135","properties":[{"key":"PathwayName","value":"MAP2K and MAPK activation"}]},{"database":"Reactome","id":"R-HSA-6802946","properties":[{"key":"PathwayName","value":"Signaling by moderate kinase activity BRAF mutants"}]},{"database":"Reactome","id":"R-HSA-6802948","properties":[{"key":"PathwayName","value":"Signaling by high-kinase activity BRAF mutants"}]},{"database":"Reactome","id":"R-HSA-6802952","properties":[{"key":"PathwayName","value":"Signaling by BRAF and RAF1 fusions"}]},{"database":"Reactome","id":"R-HSA-6802955","properties":[{"key":"PathwayName","value":"Paradoxical activation of RAF signaling by kinase inactive BRAF"}]},{"database":"Reactome","id":"R-HSA-75892","properties":[{"key":"PathwayName","value":"Platelet Adhesion to exposed collagen"}]},{"database":"Reactome","id":"R-HSA-76009","properties":[{"key":"PathwayName","value":"Platelet Aggregation (Plug Formation)"}]},{"database":"Reactome","id":"R-HSA-9649948","properties":[{"key":"PathwayName","value":"Signaling downstream of RAS mutants"}]},{"database":"Reactome","id":"R-HSA-9656223","properties":[{"key":"PathwayName","value":"Signaling by RAF1 mutants"}]},{"database":"Reactome","id":"R-HSA-9672391","properties":[{"key":"PathwayName","value":"Defective F8 cleavage by thrombin"}]},{"database":"Reactome","id":"R-HSA-9672393","properties":[{"key":"PathwayName","value":"Defective F8 binding to von Willebrand factor"}]},{"database":"Reactome","id":"R-HSA-9769735","properties":[{"key":"PathwayName","value":"Initiation of coagulation cascade"}]},{"database":"Reactome","id":"R-HSA-9769739","properties":[{"key":"PathwayName","value":"Regulation of clotting cascade"}]},{"database":"Reactome","id":"R-HSA-9769743","properties":[{"key":"PathwayName","value":"Amplification and propagation of coagulation cascade"}]},{"database":"Reactome","id":"R-HSA-9845619","properties":[{"key":"PathwayName","value":"Enhanced cleavage of VWF variant by ADAMTS13"}]},{"database":"Reactome","id":"R-HSA-9845620","properties":[{"key":"PathwayName","value":"Enhanced binding of GP1BA variant to VWF multimer:collagen"}]},{"database":"Reactome","id":"R-HSA-9845621","properties":[{"key":"PathwayName","value":"Defective VWF cleavage by ADAMTS13 variant"}]},{"database":"Reactome","id":"R-HSA-9845622","properties":[{"key":"PathwayName","value":"Defective VWF binding to collagen type I"}]},{"database":"Reactome","id":"R-HSA-9846298","properties":[{"key":"PathwayName","value":"Defective binding of VWF variant to GPIb:IX:V"}]},{"database":"SignaLink","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000110799","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"7450","properties":[{"key":"hits","value":"10 hits in 1161 CRISPR screens"}]},{"database":"ChiTaRS","id":"VWF","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P04275","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Von_Willebrand_factor","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"7450","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P04275","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P04275","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"P04275","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000110799","properties":[{"key":"ExpressionPatterns","value":"Expressed in urethra and 196 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P04275","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0071944","properties":[{"key":"GoTerm","value":"C:cell periphery"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6754744"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"6754744"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10887119"}]},{"database":"GO","id":"GO:0031091","properties":[{"key":"GoTerm","value":"C:platelet alpha granule"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"9759493"}]},{"database":"GO","id":"GO:0031093","properties":[{"key":"GoTerm","value":"C:platelet alpha granule lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0033093","properties":[{"key":"GoTerm","value":"C:Weibel-Palade body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"3082891"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"3087627"}]},{"database":"GO","id":"GO:0005518","properties":[{"key":"GoTerm","value":"F:collagen binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"2056120"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10887119"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16409464"}]},{"database":"GO","id":"GO:0019865","properties":[{"key":"GoTerm","value":"F:immunoglobulin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"3121636"}]},{"database":"GO","id":"GO:0005178","properties":[{"key":"GoTerm","value":"F:integrin binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"9079671"}]},{"database":"GO","id":"GO:0002020","properties":[{"key":"GoTerm","value":"F:protease binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15824096"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10887119"}]},{"database":"GO","id":"GO:0007596","properties":[{"key":"GoTerm","value":"P:blood coagulation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16409464"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10764791"}]},{"database":"GO","id":"GO:0031589","properties":[{"key":"GoTerm","value":"P:cell-substrate adhesion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"9079671"}]},{"database":"GO","id":"GO:0007599","properties":[{"key":"GoTerm","value":"P:hemostasis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"10887119"}]},{"database":"GO","id":"GO:0030168","properties":[{"key":"GoTerm","value":"P:platelet activation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8565074"}]},{"database":"GO","id":"GO:1902533","properties":[{"key":"GoTerm","value":"P:positive regulation of intracellular signal transduction"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14656219"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"15029268"}]},{"database":"CDD","id":"cd19941","properties":[{"key":"EntryName","value":"TIL"},{"key":"MatchStatus","value":"5"}]},{"database":"CDD","id":"cd01450","properties":[{"key":"EntryName","value":"vWFA_subfamily_ECM"},{"key":"MatchStatus","value":"3"}]},{"database":"DisProt","id":"DP02981","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"2.10.25.10:FF:000674","properties":[{"key":"EntryName","value":"Mucin-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000284","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000444","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000493","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.410:FF:000053","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.410:FF:000061","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.410:FF:000063","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"5"}]},{"database":"Gene3D","id":"3.40.50.410","properties":[{"key":"EntryName","value":"von Willebrand factor, type A domain"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR006207","properties":[{"key":"EntryName","value":"Cys_knot_C"}]},{"database":"InterPro","id":"IPR050780","properties":[{"key":"EntryName","value":"Mucin_vWF_Thrombospondin_sf"}]},{"database":"InterPro","id":"IPR036084","properties":[{"key":"EntryName","value":"Ser_inhib-like_sf"}]},{"database":"InterPro","id":"IPR002919","properties":[{"key":"EntryName","value":"TIL_dom"}]},{"database":"InterPro","id":"IPR058753","properties":[{"key":"EntryName","value":"TIL_OTOGL_Mucin"}]},{"database":"InterPro","id":"IPR037578","properties":[{"key":"EntryName","value":"Von_Willebrand_factor"}]},{"database":"InterPro","id":"IPR032361","properties":[{"key":"EntryName","value":"VWA_N2"}]},{"database":"InterPro","id":"IPR014853","properties":[{"key":"EntryName","value":"VWF/SSPO/ZAN-like_Cys-rich_dom"}]},{"database":"InterPro","id":"IPR002035","properties":[{"key":"EntryName","value":"VWF_A"}]},{"database":"InterPro","id":"IPR001007","properties":[{"key":"EntryName","value":"VWF_dom"}]},{"database":"InterPro","id":"IPR001846","properties":[{"key":"EntryName","value":"VWF_type-D"}]},{"database":"InterPro","id":"IPR036465","properties":[{"key":"EntryName","value":"vWFA_dom_sf"}]},{"database":"PANTHER","id":"PTHR11339","properties":[{"key":"EntryName","value":"EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11339:SF361","properties":[{"key":"EntryName","value":"VON WILLEBRAND FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08742","properties":[{"key":"EntryName","value":"C8"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF01826","properties":[{"key":"EntryName","value":"TIL"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF25962","properties":[{"key":"EntryName","value":"TIL_OTOGL_Mucin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00092","properties":[{"key":"EntryName","value":"VWA"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF16164","properties":[{"key":"EntryName","value":"VWA_N2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00093","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00094","properties":[{"key":"EntryName","value":"VWD"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF23244","properties":[{"key":"EntryName","value":"VWF"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF002495","properties":[{"key":"EntryName","value":"VWF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00453","properties":[{"key":"EntryName","value":"VWFADOMAIN"}]},{"database":"SMART","id":"SM00832","properties":[{"key":"EntryName","value":"C8"},{"key":"MatchStatus","value":"4"}]},{"database":"SMART","id":"SM00041","properties":[{"key":"EntryName","value":"CT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00327","properties":[{"key":"EntryName","value":"VWA"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00214","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"5"}]},{"database":"SMART","id":"SM00215","properties":[{"key":"EntryName","value":"VWC_out"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00216","properties":[{"key":"EntryName","value":"VWD"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57603","properties":[{"key":"EntryName","value":"FnI-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57567","properties":[{"key":"EntryName","value":"Serine protease inhibitors"},{"key":"MatchStatus","value":"5"}]},{"database":"SUPFAM","id":"SSF53300","properties":[{"key":"EntryName","value":"vWA-like"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS01185","properties":[{"key":"EntryName","value":"CTCK_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01225","properties":[{"key":"EntryName","value":"CTCK_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50234","properties":[{"key":"EntryName","value":"VWFA"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS01208","properties":[{"key":"EntryName","value":"VWFC_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50184","properties":[{"key":"EntryName","value":"VWFC_2"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS51233","properties":[{"key":"EntryName","value":"VWFD"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPLVDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPGTSLSRDCNTCICRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDLRIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSGLAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADNLRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGETVKIGCNTCVCQDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGRYIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVDFGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPYLDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGYECEWRYNSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCEVAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTDAPVSPTTLYVEDISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASRITLLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTLSPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKAVVILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDLPTMVTLGNSFLHKLCSGFVRICMDEDGNEKRPGDVWTLPDQCHTVTCQPDGQTLLKSHRVNCDRGLRPSCPNSQSPVKVEETCGCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNKEQDLEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEVNVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRDGTVTTDWKTLVQEWTVQRPGQTCQPILEEQCLVPDSSHCQVLLLPLFAECHKVLAPATFYAICQQDSCHQEQVCEVIASYAHLCRTNGVCVDWRTPDFCAMSCPPSLVYNHCEHGCPRHCDGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQICTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHCERGLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVNSTVSCPLGYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMYSIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSK","length":2813,"molWeight":309265,"crc64":"D5C1C78360917C29","md5":"4F26ADB6E954C8E065F64B10AC553F34"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":9,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":2,"DISEASE":3,"SEQUENCE CAUTION":1,"WEB RESOURCE":2},"countByFeatureType":{"Signal":1,"Chain":2,"Domain":15,"Region":4,"Motif":1,"Glycosylation":26,"Disulfide bond":34,"Alternative sequence":3,"Natural variant":60,"Mutagenesis":2,"Sequence conflict":4,"Beta strand":150,"Turn":33,"Helix":86},"uniParcId":"UPI00001AE7EE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"L8E853","uniProtkbId":"L8E853_HUMAN","entryAudit":{"firstPublicDate":"2013-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-04-03","entryVersion":49,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCQ25771.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016619"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"value":"von Willebrand factor"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"value":"vWF"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCQ25771.1"}],"value":"VWF"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00055715"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"value":"Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025858"}],"value":"Multimeric. Interacts with F8"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"value":"Localized to storage granules"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00580"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":2715,"modifier":"EXACT"}},"description":"von Willebrand factor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003988435"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"VWFD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51233"}]},{"type":"Domain","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":560,"modifier":"EXACT"}},"description":"VWFD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51233"}]},{"type":"Domain","location":{"start":{"value":865,"modifier":"EXACT"},"end":{"value":1032,"modifier":"EXACT"}},"description":"VWFD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51233"}]},{"type":"Domain","location":{"start":{"value":1277,"modifier":"EXACT"},"end":{"value":1453,"modifier":"EXACT"}},"description":"VWFA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50234"}]},{"type":"Domain","location":{"start":{"value":1498,"modifier":"EXACT"},"end":{"value":1665,"modifier":"EXACT"}},"description":"VWFA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50234"}]},{"type":"Domain","location":{"start":{"value":1691,"modifier":"EXACT"},"end":{"value":1871,"modifier":"EXACT"}},"description":"VWFA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50234"}]},{"type":"Domain","location":{"start":{"value":1948,"modifier":"EXACT"},"end":{"value":2124,"modifier":"EXACT"}},"description":"VWFD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51233"}]},{"type":"Domain","location":{"start":{"value":2255,"modifier":"EXACT"},"end":{"value":2328,"modifier":"EXACT"}},"description":"VWFC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50184"}]},{"type":"Domain","location":{"start":{"value":2429,"modifier":"EXACT"},"end":{"value":2495,"modifier":"EXACT"}},"description":"VWFC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50184"}]},{"type":"Domain","location":{"start":{"value":2580,"modifier":"EXACT"},"end":{"value":2645,"modifier":"EXACT"}},"description":"VWFC","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50184"}]},{"type":"Disulfide bond","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Disulfide bond","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Disulfide bond","location":{"start":{"value":1272,"modifier":"EXACT"},"end":{"value":1458,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7A6O"}]},{"type":"Disulfide bond","location":{"start":{"value":1993,"modifier":"EXACT"},"end":{"value":2001,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00580"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7A6O"}],"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022685"}],"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00580"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"},{"evidenceCode":"ECO:0000256","source":"PIRNR","id":"PIRNR002495"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-976DMTCV2EACE","citationType":"submission","authors":["Polin H.","Reiter A.","Schuster G.","Brisner M.","Atzmueller S.","Gabriel C."],"title":"First description of von Willebrand factor variant VWF00435(2561G>R, 8148T>W), associated with type 1.","publicationDate":"JAN-2013","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"CCQ25771.1"}]},{"referenceNumber":2,"citation":{"id":"33883551","citationType":"journal article","authors":["Arce N.A.","Cao W.","Brown A.K.","Legan E.R.","Wilson M.S.","Xu E.R.","Berndt M.C.","Emsley J.","Zhang X.F.","Li R."],"citationCrossReferences":[{"database":"PubMed","id":"33883551"},{"database":"DOI","id":"10.1038/s41467-021-22634-x"}],"title":"Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module.","publicationDate":"2021","journal":"Nat. Commun.","firstPage":"2360","lastPage":"2360","volume":"12"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 1262-1466","DISULFIDE BONDS"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7A6O"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"HF571250","properties":[{"key":"ProteinId","value":"CCQ25771.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PDB","id":"7A6O","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.12 A"},{"key":"Chains","value":"A=1262-1466"}]},{"database":"SMR","id":"L8E853","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"L8E853","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6262482at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"VWF","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0071944","properties":[{"key":"GoTerm","value":"C:cell periphery"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0033093","properties":[{"key":"GoTerm","value":"C:Weibel-Palade body"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005518","properties":[{"key":"GoTerm","value":"F:collagen binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0019865","properties":[{"key":"GoTerm","value":"F:immunoglobulin binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0005178","properties":[{"key":"GoTerm","value":"F:integrin binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0002020","properties":[{"key":"GoTerm","value":"F:protease binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0051087","properties":[{"key":"GoTerm","value":"F:protein-folding chaperone binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0031589","properties":[{"key":"GoTerm","value":"P:cell-substrate adhesion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0030168","properties":[{"key":"GoTerm","value":"P:platelet activation"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"CDD","id":"cd19941","properties":[{"key":"EntryName","value":"TIL"},{"key":"MatchStatus","value":"5"}]},{"database":"CDD","id":"cd01450","properties":[{"key":"EntryName","value":"vWFA_subfamily_ECM"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"2.10.25.10:FF:000674","properties":[{"key":"EntryName","value":"Mucin-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000284","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000444","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000493","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.410:FF:000053","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.410:FF:000061","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.410:FF:000063","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"5"}]},{"database":"Gene3D","id":"3.40.50.410","properties":[{"key":"EntryName","value":"von Willebrand factor, type A domain"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR050780","properties":[{"key":"EntryName","value":"Mucin_vWF_Thrombospondin_sf"}]},{"database":"InterPro","id":"IPR036084","properties":[{"key":"EntryName","value":"Ser_inhib-like_sf"}]},{"database":"InterPro","id":"IPR002919","properties":[{"key":"EntryName","value":"TIL_dom"}]},{"database":"InterPro","id":"IPR058753","properties":[{"key":"EntryName","value":"TIL_OTOGL_Mucin"}]},{"database":"InterPro","id":"IPR037578","properties":[{"key":"EntryName","value":"Von_Willebrand_factor"}]},{"database":"InterPro","id":"IPR032361","properties":[{"key":"EntryName","value":"VWA_N2"}]},{"database":"InterPro","id":"IPR014853","properties":[{"key":"EntryName","value":"VWF/SSPO/ZAN-like_Cys-rich_dom"}]},{"database":"InterPro","id":"IPR002035","properties":[{"key":"EntryName","value":"VWF_A"}]},{"database":"InterPro","id":"IPR001007","properties":[{"key":"EntryName","value":"VWF_dom"}]},{"database":"InterPro","id":"IPR001846","properties":[{"key":"EntryName","value":"VWF_type-D"}]},{"database":"InterPro","id":"IPR036465","properties":[{"key":"EntryName","value":"vWFA_dom_sf"}]},{"database":"PANTHER","id":"PTHR11339","properties":[{"key":"EntryName","value":"EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11339:SF361","properties":[{"key":"EntryName","value":"VON WILLEBRAND FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08742","properties":[{"key":"EntryName","value":"C8"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF01826","properties":[{"key":"EntryName","value":"TIL"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF25962","properties":[{"key":"EntryName","value":"TIL_OTOGL_Mucin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00092","properties":[{"key":"EntryName","value":"VWA"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF16164","properties":[{"key":"EntryName","value":"VWA_N2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00093","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00094","properties":[{"key":"EntryName","value":"VWD"},{"key":"MatchStatus","value":"4"}]},{"database":"PIRSF","id":"PIRSF002495","properties":[{"key":"EntryName","value":"VWF"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00453","properties":[{"key":"EntryName","value":"VWFADOMAIN"}]},{"database":"SMART","id":"SM00832","properties":[{"key":"EntryName","value":"C8"},{"key":"MatchStatus","value":"4"}]},{"database":"SMART","id":"SM00327","properties":[{"key":"EntryName","value":"VWA"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00214","properties":[{"key":"EntryName","value":"VWC"},{"key":"MatchStatus","value":"5"}]},{"database":"SMART","id":"SM00215","properties":[{"key":"EntryName","value":"VWC_out"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00216","properties":[{"key":"EntryName","value":"VWD"},{"key":"MatchStatus","value":"4"}]},{"database":"SUPFAM","id":"SSF57603","properties":[{"key":"EntryName","value":"FnI-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57567","properties":[{"key":"EntryName","value":"Serine protease inhibitors"},{"key":"MatchStatus","value":"5"}]},{"database":"SUPFAM","id":"SSF53300","properties":[{"key":"EntryName","value":"vWA-like"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50234","properties":[{"key":"EntryName","value":"VWFA"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS01208","properties":[{"key":"EntryName","value":"VWFC_1"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50184","properties":[{"key":"EntryName","value":"VWFC_2"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS51233","properties":[{"key":"EntryName","value":"VWFD"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPLVDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPGTSLSRDCNTCICRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDLRIQRTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSGLAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADNLRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGETVKIGCNTCVCRDQKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGRYIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVDFGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPYLDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGYECEWRYNSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCEVAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTDAPVSPTTLYVEDISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASRIALLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTLSPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKAVVILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDLPTMVTLGNSFLHKLCSGFVRICMDEDGNEKRPGDVWTLPDQCHTVTCQPDGQTLLKSHRVNCDRGLRPSCPNSQSPVKVEETCGCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNKEQDLEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEVNVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRDGTVTTDWKTLVQEWTVQRPGQTCQPILEEQCLVPDSSHCQVLLLPLFAECHKVLAPATFYAICQQDSCHQEQVCEVIASYAHLCRTNGVCVDWRTPDFCAMSCPPSLVYNHCEHGCPRHCDGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQICTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHCERGLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVNSTVSCPLGYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTC","length":2715,"molWeight":298380,"crc64":"0EC36D79BBCD74C2","md5":"9A755AF40CF91E7B16A9F22F9037283B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":10,"Disulfide bond":4},"uniParcId":"UPI0002AB2776"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QL97","uniProtkbId":"A0ACI8QL97_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000565739.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00016619"}],"value":"von Willebrand factor"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000565739.1"}],"value":"VWF"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00025858"}],"value":"Multimeric. Interacts with F8"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00580"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":1173,"modifier":"EXACT"}},"description":"von Willebrand factor","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051555867"},{"type":"Domain","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"VWFD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51233"}]},{"type":"Domain","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":560,"modifier":"EXACT"}},"description":"VWFD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51233"}]},{"type":"Domain","location":{"start":{"value":865,"modifier":"EXACT"},"end":{"value":1032,"modifier":"EXACT"}},"description":"VWFD","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51233"}]},{"type":"Domain","location":{"start":{"value":1084,"modifier":"EXACT"},"end":{"value":1172,"modifier":"EXACT"}},"description":"CTCK","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS01225"}]},{"type":"Disulfide bond","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Disulfide bond","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00580"}]},{"type":"Disulfide bond","location":{"start":{"value":1084,"modifier":"EXACT"},"end":{"value":1134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00039"}]},{"type":"Disulfide bond","location":{"start":{"value":1099,"modifier":"EXACT"},"end":{"value":1148,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00039"}]},{"type":"Disulfide bond","location":{"start":{"value":1110,"modifier":"EXACT"},"end":{"value":1164,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00039"}]},{"type":"Disulfide bond","location":{"start":{"value":1114,"modifier":"EXACT"},"end":{"value":1166,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00039"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023084"}],"id":"KW-0094","category":"Biological process","name":"Blood coagulation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022685"}],"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00580"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022696"}],"id":"KW-0356","category":"Biological process","name":"Hemostasis"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QL97"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QL97"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000565739.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000565739.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000565739.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000565739.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005845","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC005846","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC005904","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KC877500","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000895680.1","properties":[{"key":"ProteinId","value":"ENSP00000565739.1"},{"key":"GeneId","value":"ENSG00000110799.15"}]},{"database":"HGNC","id":"HGNC:12726","properties":[{"key":"GeneName","value":"VWF"}]},{"database":"OpenTargets","id":"ENSG00000110799","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155810","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"CDD","id":"cd19941","properties":[{"key":"EntryName","value":"TIL"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"2.10.25.10:FF:000674","properties":[{"key":"EntryName","value":"Mucin-2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000444","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR006207","properties":[{"key":"EntryName","value":"Cys_knot_C"}]},{"database":"InterPro","id":"IPR050780","properties":[{"key":"EntryName","value":"Mucin_vWF_Thrombospondin_sf"}]},{"database":"InterPro","id":"IPR036084","properties":[{"key":"EntryName","value":"Ser_inhib-like_sf"}]},{"database":"InterPro","id":"IPR002919","properties":[{"key":"EntryName","value":"TIL_dom"}]},{"database":"InterPro","id":"IPR014853","properties":[{"key":"EntryName","value":"VWF/SSPO/ZAN-like_Cys-rich_dom"}]},{"database":"InterPro","id":"IPR001007","properties":[{"key":"EntryName","value":"VWF_dom"}]},{"database":"InterPro","id":"IPR001846","properties":[{"key":"EntryName","value":"VWF_type-D"}]},{"database":"PANTHER","id":"PTHR11339","properties":[{"key":"EntryName","value":"EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11339:SF361","properties":[{"key":"EntryName","value":"VON WILLEBRAND FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08742","properties":[{"key":"EntryName","value":"C8"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF01826","properties":[{"key":"EntryName","value":"TIL"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00094","properties":[{"key":"EntryName","value":"VWD"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF23244","properties":[{"key":"EntryName","value":"VWF"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00832","properties":[{"key":"EntryName","value":"C8"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00041","properties":[{"key":"EntryName","value":"CT"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00215","properties":[{"key":"EntryName","value":"VWC_out"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00216","properties":[{"key":"EntryName","value":"VWD"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF57567","properties":[{"key":"EntryName","value":"Serine protease inhibitors"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS01185","properties":[{"key":"EntryName","value":"CTCK_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01225","properties":[{"key":"EntryName","value":"CTCK_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51233","properties":[{"key":"EntryName","value":"VWFD"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPLVDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGMEYRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPGTSLSRDCNTCICRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDLRIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSGLAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADNLRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGETVKIGCNTCVCQDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGRYIILLLGKALSVVWDRHLSISVVLKQTYQGYKEENNTGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMYSIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSK","length":1173,"molWeight":129230,"crc64":"FD77E9600B257E05","md5":"410D93C4E2A0D9310D063A60212F0EE0"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":4,"Disulfide bond":6},"uniParcId":"UPI0040324D88"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"I3L4K4","uniProtkbId":"I3L4K4_HUMAN","entryAudit":{"firstPublicDate":"2012-07-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-07-11","entryVersion":73,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461331.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461331.1"}],"value":"von Willebrand factor"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461331.1"}],"value":"VWF"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5014098411"}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"I3L4K4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461331.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461331.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16541075","citationType":"journal article","authoringGroup":["Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team"],"authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A.","null."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461331.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000461331.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC005845","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC005846","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC005904","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KC877500","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"I3L4K4","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000321023.5","properties":[{"key":"ProteinId","value":"ENSP00000461331.1"},{"key":"GeneId","value":"ENSG00000110799.15"}]},{"database":"Ensembl","id":"ENST00000538563.1","properties":[{"key":"ProteinId","value":"ENSP00000459134.1"},{"key":"GeneId","value":"ENSG00000110799.15"}]},{"database":"UCSC","id":"uc001qno.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:12726","properties":[{"key":"GeneName","value":"VWF"}]},{"database":"OpenTargets","id":"ENSG00000110799","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000110799","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155810","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2941054_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6262482at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"VWF","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"Bgee","id":"ENSG00000110799","properties":[{"key":"ExpressionPatterns","value":"Expressed in urethra and 196 other cell types or tissues"}]}],"sequence":{"value":"MIPARFAGVLLALALILPETRCLQMPSPVGELRSIKVAQNCPILWGHRMRRKESKTWMDY","length":60,"molWeight":6894,"crc64":"DC8986DB81082647","md5":"758C0EC464B9BA970413D7BA2277B102"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1},"uniParcId":"UPI00025A309E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H2DLA2","uniProtkbId":"H2DLA2_HUMAN","entryAudit":{"firstPublicDate":"2012-03-21","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2012-03-21","entryVersion":48,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEY75227.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"4: Predicted","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEY75227.1"}],"value":"von Willebrand factor"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEY75227.1"}],"value":"VWF"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]}],"features":[{"type":"Domain","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"VWFA","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50234"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEY75227.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEY75227.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"}],"references":[{"referenceNumber":1,"citation":{"id":"22479377","citationType":"journal article","authors":["Dong J.","Zhao X.","Shi S.","Ma Z.","Liu M.","Wu Q.","Ruan C.","Dong N."],"citationCrossReferences":[{"database":"PubMed","id":"22479377"},{"database":"DOI","id":"10.1371/journal.pone.0033263"}],"title":"Identification and Functional Analysis of a Novel von Willebrand Factor Mutation in a Family with Type 2A von Willebrand Disease.","publicationDate":"2012","journal":"PLoS ONE","firstPage":"E33263","lastPage":"E33263","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEY75227.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JN625247","properties":[{"key":"ProteinId","value":"AEY75227.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H2DLA2","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"H2DLA2","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6262482at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"VWF","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"CDD","id":"cd01450","properties":[{"key":"EntryName","value":"vWFA_subfamily_ECM"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.410:FF:000053","properties":[{"key":"EntryName","value":"von Willebrand factor"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.410","properties":[{"key":"EntryName","value":"von Willebrand factor, type A domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR050525","properties":[{"key":"EntryName","value":"ECM_Assembly_Org"}]},{"database":"InterPro","id":"IPR002035","properties":[{"key":"EntryName","value":"VWF_A"}]},{"database":"InterPro","id":"IPR036465","properties":[{"key":"EntryName","value":"vWFA_dom_sf"}]},{"database":"PANTHER","id":"PTHR24020","properties":[{"key":"EntryName","value":"COLLAGEN ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24020:SF87","properties":[{"key":"EntryName","value":"COLLAGEN ALPHA-1(VI) CHAIN-LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00092","properties":[{"key":"EntryName","value":"VWA"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00453","properties":[{"key":"EntryName","value":"VWFADOMAIN"}]},{"database":"SMART","id":"SM00327","properties":[{"key":"EntryName","value":"VWA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53300","properties":[{"key":"EntryName","value":"vWA-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50234","properties":[{"key":"EntryName","value":"VWFA"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"QIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMGQDSIHVTVLQYSYMVTVEYPFSEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTLSPAP","length":259,"molWeight":28570,"crc64":"38987C66EE853150","md5":"15FA3072D5FD4017A8194E53A0127C59"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI00024BFAD3"}}]}