{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P61088","secondaryAccessions":["Q16781","Q53Y81"],"uniProtkbId":"UBE2N_HUMAN","entryAudit":{"firstPublicDate":"2004-04-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-04-26","entryVersion":220,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Ubiquitin-conjugating enzyme E2 N"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20061386"}],"value":"2.3.2.23"}]},"alternativeNames":[{"fullName":{"value":"Bendless-like ubiquitin-conjugating enzyme"}},{"fullName":{"value":"E2 ubiquitin-conjugating enzyme N"}},{"fullName":{"value":"Ubc13"}},{"fullName":{"value":"UbcH13"}},{"fullName":{"value":"Ubiquitin carrier protein N"}},{"fullName":{"value":"Ubiquitin-protein ligase N"}}]},"genes":[{"geneName":{"value":"UBE2N"},"synonyms":[{"value":"BLU"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10089880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562038"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19269966"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19825828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20061386"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21512573"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28469175"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31006531"}],"value":"The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:28469175, PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.","ecNumber":"2.3.2.23","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00388"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU10133"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20061386"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P61089"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20725033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22325355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22367539"}],"value":"Activity is inhibited by binding to OTUB1, which prevents 'Lys-63'-linked polyubiquitination (PubMed:20725033, PubMed:22325355, PubMed:22367539). Activity is inhibited by GPS2, leading to prevent 'Lys-63'-linked polyubiquitination (By similarity)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00388"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P61089"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10089880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11473255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14562038"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16215985"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16307917"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17108083"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17130289"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18316726"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18615712"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18719106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19203578"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19340006"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20725033"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22325355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22367539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22589545"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28469175"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29626159"}],"value":"Heterodimer with UBE2V2 (PubMed:10089880, PubMed:11473255, PubMed:14562038, PubMed:16307917). Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity (PubMed:16307917). Interacts with RNF8 and RNF168 (PubMed:16215985, PubMed:19203578). Interacts with RNF11 (PubMed:18615712). Interacts with the E3 ligases, HLTF and SHPRH; the interactions promote the 'Lys-63'-linked polyubiquitination of PCNA upon genotoxic stress and lead to DNA repair (PubMed:17108083, PubMed:17130289, PubMed:18316726, PubMed:18719106). Interacts with ARIH2 (via RING-type 2) (PubMed:19340006). Interacts with OTUB1; leading to inhibit E2-conjugating activity (PubMed:20725033, PubMed:22325355, PubMed:22367539). Interacts with GPS2; leading to inhibit E2-conjugating activity (By similarity). Interacts with RIGI and RNF135; involved in RIGI ubiquitination and activation (PubMed:28469175). Interacts with ZNRF1 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