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In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:28661582)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34287"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:57504"},{"database":"ChEBI","id":"CHEBI:57924"}],"ecNumber":"1.14.18.1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28661582"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:34288"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"28661582"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-tyrosine + O2 = L-dopaquinone + 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DCT in response to blue light in 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Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair"}],"commentType":"POLYMORPHISM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2342539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7955413"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9158138"}],"value":"Compound heterozygosity for the R402Q polymorphism and a mutant allele of TYR is a common cause of autosomal recessive ocular albinism. The R402Q polymorphism is also found in Waardenburg syndrome type II with ocular albinism in association with a deletion in the MITF gene"}],"commentType":"POLYMORPHISM"},{"commentType":"DISEASE","disease":{"diseaseId":"Albinism, oculocutaneous, 1A","diseaseAccession":"DI-02088","acronym":"OCA1A","description":"An autosomal recessive disorder in which the biosynthesis of melanin pigment is absent in skin, hair, and eyes. It is characterized by complete lack of tyrosinase activity due to production of an inactive enzyme. Patients present with a life-long absence of melanin pigment after birth, and manifest increased sensitivity to ultraviolet radiation with predisposition to skin cancer. Visual anomalies include decreased acuity, nystagmus, strabismus and photophobia.","diseaseCrossReference":{"database":"MIM","id":"203100"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10571953"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10671066"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10987646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11295837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11858948"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1487241"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15146472"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1642278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1899321"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1943686"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1970634"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22981120"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2342539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23504663"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24934919"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7902671"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7955413"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8026428"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8128955"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8434585"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8644824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9259202"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Albinism, oculocutaneous, 1B","diseaseAccession":"DI-02089","acronym":"OCA1B","description":"An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. It is characterized by partial lack of tyrosinase activity. Patients have white hair at birth that rapidly turns yellow or blond. They manifest the development of minimal-to-moderate amounts of cutaneous and ocular pigment. Some patients may have with white hair in the warmer areas (scalp and axilla) and progressively darker hair in the cooler areas (extremities). This variant phenotype is due to a loss of tyrosinase activity above 35-37 degrees C.","diseaseCrossReference":{"database":"MIM","id":"606952"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10987646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1900309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1903591"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8128955"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9259202"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the tyrosinase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAA61241.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous 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