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In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 (PubMed:12393603). In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities (PubMed:11468175). In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z2S7"}],"value":"Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG"}],"commentType":"FUNCTION","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z2S7"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11468175"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12393603"}],"value":"Can form homodimers, however it is likely to function as a monomer (By similarity). Interacts with NFKB1 (PubMed:11468175, PubMed:12393603). Interacts (via N-terminus) with JUN and FOS; these interactions inhibit the binding of active AP1 to its target DNA (By similarity)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z2S7"}],"value":"Interacts with MYOD1 (By similarity). Interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity)"}],"commentType":"SUBUNIT","molecule":"Isoform 1"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q99576","intActId":"EBI-750174"},"interactantTwo":{"uniProtKBAccession":"Q9Y6D9","geneName":"MAD1L1","intActId":"EBI-742610"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99576","intActId":"EBI-750174"},"interactantTwo":{"uniProtKBAccession":"Q04864-2","geneName":"REL","intActId":"EBI-10829018"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99576-3","intActId":"EBI-10294415"},"interactantTwo":{"uniProtKBAccession":"Q0VDD7","geneName":"BRME1","intActId":"EBI-741210"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99576-3","intActId":"EBI-10294415"},"interactantTwo":{"uniProtKBAccession":"Q9Y6D9","geneName":"MAD1L1","intActId":"EBI-742610"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z2S7"}],"value":"Localization depends on differentiation status of myoblasts (By similarity). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblast; localizes to the nucleus (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z2S7"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z2S7"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q99576-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q99576-3"],"sequenceIds":["VSP_012689"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q99576-5"],"sequenceIds":["VSP_061579"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11313722"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12393603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26752201"}],"value":"Ubiquitously expressed, including in the fetal brain and liver (PubMed:26752201). Expressed in brain, lung, spleen and skeletal muscle (PubMed:11313722, PubMed:12393603). Lower levels detected in heart and kidney (PubMed:11313722, PubMed:12393603). Not detected in the pancreas (PubMed:11313722). In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage (PubMed:12393603). Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes (PubMed:11313722). Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells (PubMed:12393603)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26752201"}],"value":"Induced in T-lymphocytes by IL2 deprivation"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z2S7"}],"value":"The leucine-zipper is involved in homodimerization"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TSC-22/Dip/Bun family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"CAB53669.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"TSC22 domain family protein 3","featureId":"PRO_0000219370"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"AP1-binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"Leucine-zipper"},{"type":"Region","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37316325"}]},{"type":"Modified residue","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"in isoform 3","featureId":"VSP_061579","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_012689","alternativeSequence":{"originalSequence":"MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDN","alternativeSequences":["MAQSKLDCRSPVGLDCCNCCLDLAHRSGLQRGSSGENNNPGSPTVSNFRQLQEKLVFENLNTDKLNSIMRQDSLEPVLRDPCYLINEGICNRNIDQTMLSILLFFH"]}},{"type":"Sequence conflict","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"in Ref. 1; CAA90644","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["F"]}},{"type":"Modified residue","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"},"sequence":"Q99576-3"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"},"sequence":"Q99576-3"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"},"sequence":"Q99576-5"},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37316325"}]}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"8982256","citationType":"journal article","authors":["Vogel P.","Maegert H.-J.","Cieslak A.","Adermann K.","Forssmann W.-G."],"citationCrossReferences":[{"database":"PubMed","id":"8982256"},{"database":"DOI","id":"10.1016/s0167-4781(96)00177-7"}],"title":"hDIP -- a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues.","publicationDate":"1996","journal":"Biochim. 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