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Activation of the channel requires the presence of PI(4,5)P2. PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels (PubMed:15852009). Activated by intracellular Ca(2+) (PubMed:15852009)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22128173"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25559186"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37857704"}],"value":"Homotetramer (PubMed:37857704). Isoform 2 and isoform 3 interact with the C-terminus of isoform 1 in a thermosensitive manner with decreased interaction at 21 degrees Celsius compared to 37 degrees Celsius (PubMed:22128173). Interacts (via N-terminus and C-terminus domains) with TCAF1; the interaction stimulates TRPM8 channel activity (PubMed:25559186). 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