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On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells even stressed or infected by bacteria (PubMed:31959982). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. 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Classified as a public TCR clonotype, it is preferentially selected in effector memory CD8-positive T cells among multiple HLA-A*02:01 carriers/individuals and confers long-lived immunity against IAV infection. Can cross-recognize sporadically emerging IAV variants by molecular mimicry, inducing immunity toward different influenza strains (PubMed:12796775, PubMed:18275829, PubMed:1833769, PubMed:27036003, PubMed:29997621, PubMed:7807026). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A075B6N1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12796775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18275829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27036003"}],"value":"Disulfide-linked heterodimer with TRAV27*01J42*01C*01 alpha chain. The TR primarily interacts via its CDR3-beta domain with M/matrix protein 1-derived peptide (GILGFVFTL) displayed by HLA-A*02.01 in a 'peg-notch' recognition mode (PubMed:12796775, PubMed:18275829, PubMed:27036003). The alpha-beta TR associates with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains (via TM domain), respectively. The association of the CD247 homodimer is the last step of TCR assembly in the endoplasmic reticulum and is required for transport to the cell surface (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29997621"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29997621"}],"value":"Expressed in M/matrix protein 1-specific effector memory CD8-positive T cells readily detectable in the peripheral blood, secondary lymphoid organs and lung (primary site of infection) of IAV infected individuals"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12796775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18275829"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11096259"}],"value":"The complementarity-determining region CDR1 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12796775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18275829"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11096259"}],"value":"The complementarity-determining region CDR2 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12796775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18275829"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1833769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29997621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7807026"}],"value":"The complementarity-determining region CDR3 confers specificity to the peptide antigen. Assumes a loop structure that recognizes the peptide-HLA-A*02-B2M complex. Recognizes M/matrix protein 1-derived peptide mainly via its xRSx motif"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P01850"}],"value":"The connecting peptide (CP) domain is essential for signal transmission in response to antigenic stimulation, likely downstream from ZAP70 recruitment"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P01850"}],"value":"The TM domain mediates the interaction with the CD3 subunits"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12796775"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18275829"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27036003"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"7807026"}],"value":"The JM22 clone described as a variant of the public clonotype differs by one amino acid in the CDR3-beta domain"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1833769"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27036003"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29997621"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7807026"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19568742"}],"value":"This sequence is an example of a full-length TR beta chain. M/matrix protein 1-specific TRBV19*01J2S7*01C*02 TCR beta chain is generated by somatic recombination of variable TRBV19 (AC A0A075B6N1), diversity (AC P0DPI4) and joining TRBJ2-7 (AC A0A0A0MT78) gene segments spliced to constant TRBC2 (AC A0A5B9) gene segment (PubMed:1833769, PubMed:27036003, PubMed:29997621, PubMed:7807026). 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