{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P09493","secondaryAccessions":["B7Z5T7","D9YZV2","D9YZV3","D9YZV8","P09494","P10469","Q6DV89","Q6DV90","Q7Z6L8","Q86W64","Q96IK2","Q9UCI1","Q9UCI2","Q9UCY9","Q9Y427"],"uniProtkbId":"TPM1_HUMAN","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1990-11-01","entryVersion":246,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Tropomyosin alpha-1 chain"}},"alternativeNames":[{"fullName":{"value":"Alpha-tropomyosin"}},{"fullName":{"value":"Tropomyosin-1"}}]},"genes":[{"geneName":{"value":"TPM1"},"synonyms":[{"value":"C15orf13"},{"value":"TMSA"}]}],"comments":[{"texts":[{"value":"Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04268"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04692"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23170982"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26873245"}],"value":"Homodimer (PubMed:23170982). Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG (By similarity). Interacts (via N-terminus) with LMOD2 (via N-terminus) and TMOD1 (via N-terminus) (PubMed:26873245)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P09493","intActId":"EBI-351158"},"interactantTwo":{"uniProtKBAccession":"Q8TAB5","geneName":"C1orf216","intActId":"EBI-747505"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493","intActId":"EBI-351158"},"interactantTwo":{"uniProtKBAccession":"Q8TC20","geneName":"CAGE1","intActId":"EBI-10196469"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493","intActId":"EBI-351158"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493","intActId":"EBI-351158"},"interactantTwo":{"uniProtKBAccession":"Q9BQD3","geneName":"KXD1","intActId":"EBI-739657"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493","intActId":"EBI-351158"},"interactantTwo":{"uniProtKBAccession":"Q9Y6D9","geneName":"MAD1L1","intActId":"EBI-742610"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493","intActId":"EBI-351158"},"interactantTwo":{"uniProtKBAccession":"Q8N0S2","geneName":"SYCE1","intActId":"EBI-6872807"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493","intActId":"EBI-351158"},"interactantTwo":{"uniProtKBAccession":"P13805","geneName":"TNNT1","intActId":"EBI-726527"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493","intActId":"EBI-351158"},"interactantTwo":{"uniProtKBAccession":"P07951","geneName":"TPM2","intActId":"EBI-352633"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-5","intActId":"EBI-10196387"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-5","intActId":"EBI-10196387"},"interactantTwo":{"uniProtKBAccession":"V9HW56","geneName":"HEL-S-108","intActId":"EBI-10330141"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-5","intActId":"EBI-10196387"},"interactantTwo":{"uniProtKBAccession":"Q9BQD3","geneName":"KXD1","intActId":"EBI-739657"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-5","intActId":"EBI-10196387"},"interactantTwo":{"uniProtKBAccession":"Q8N0S2","geneName":"SYCE1","intActId":"EBI-6872807"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-5","intActId":"EBI-10196387"},"interactantTwo":{"uniProtKBAccession":"P0C1Z6-2","geneName":"TFPT","intActId":"EBI-10178002"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"Q9UL45","geneName":"BLOC1S6","intActId":"EBI-465781"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"Q8TC20-4","geneName":"CAGE1","intActId":"EBI-11522698"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"Q8TD31-3","geneName":"CCHCR1","intActId":"EBI-10175300"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"Q2M329","geneName":"CFAP184","intActId":"EBI-12382974"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"Q8IZT9","geneName":"FAM9C","intActId":"EBI-2870039"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"P02671-2","geneName":"FGA","intActId":"EBI-9640259"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"O14879","geneName":"IFIT3","intActId":"EBI-745127"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"Q9BQD3","geneName":"KXD1","intActId":"EBI-739657"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"Q9Y6D9","geneName":"MAD1L1","intActId":"EBI-742610"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"P62195","geneName":"PSMC5","intActId":"EBI-357745"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"Q8N0S2","geneName":"SYCE1","intActId":"EBI-6872807"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"P0C1Z6","geneName":"TFPT","intActId":"EBI-1245626"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"P13805-3","geneName":"TNNT1","intActId":"EBI-12151635"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P09493-10","intActId":"EBI-12123928"},"interactantTwo":{"uniProtKBAccession":"O95619","geneName":"YEATS4","intActId":"EBI-399269"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04692"}],"value":"Associates with F-actin stress fibers"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04692"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Skeletal muscle"},{"value":"TPM1alpha"}],"isoformIds":["P09493-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Smooth muscle"}],"isoformIds":["P09493-2"],"sequenceIds":["VSP_006576","VSP_006578","VSP_006579"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"Fibroblast"},{"value":"TM3"}],"isoformIds":["P09493-3"],"sequenceIds":["VSP_006577","VSP_006579"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P09493-4"],"sequenceIds":["VSP_006577"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["P09493-5"],"sequenceIds":["VSP_017498","VSP_017499"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"value":"10"},{"value":"TPM1kappa"}],"isoformIds":["P09493-6"],"sequenceIds":["VSP_036064"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"isoformIds":["P09493-7"],"sequenceIds":["VSP_036064","VSP_006579"],"isoformSequenceStatus":"Described"},{"name":{"value":"8"},"isoformIds":["P09493-8"],"sequenceIds":["VSP_047297","VSP_047298","VSP_047299","VSP_047300","VSP_006579"],"isoformSequenceStatus":"Described"},{"name":{"value":"9"},"isoformIds":["P09493-9"],"sequenceIds":["VSP_006579"],"isoformSequenceStatus":"Described"},{"name":{"value":"10"},"isoformIds":["P09493-10"],"sequenceIds":["VSP_047299","VSP_047300","VSP_047301"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Additional isoforms seem to exist."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15249230"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.15"}],"value":"Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17895359"}],"value":"Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells"}],"commentType":"PTM"},{"commentType":"MASS SPECTROMETRY","molecule":"Isoform 3","method":"MALDI","molWeight":32875.93,"molWeightError":0.0,"note":"The measured range is 1-284.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11840567"}]},{"commentType":"DISEASE","disease":{"diseaseId":"Cardiomyopathy, familial hypertrophic, 3","diseaseAccession":"DI-00235","acronym":"CMH3","description":"A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.","diseaseCrossReference":{"database":"MIM","id":"115196"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12974739"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23170982"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7898523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8205619"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8523464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822100"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Cardiomyopathy, dilated, 1Y","diseaseAccession":"DI-00226","acronym":"CMD1Y","description":"A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.","diseaseCrossReference":{"database":"MIM","id":"611878"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11273725"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Left ventricular non-compaction 9","diseaseAccession":"DI-03886","acronym":"LVNC9","description":"A form of left ventricular non-compaction, a cardiomyopathy due to myocardial morphogenesis arrest and characterized by a hypertrophic left ventricle, a severely thickened 2-layered myocardium, numerous prominent trabeculations, deep intertrabecular recesses, and poor systolic function. Clinical manifestations are variable. Some affected individuals experience no symptoms at all, others develop heart failure. In some cases, left ventricular non-compaction is associated with other congenital heart anomalies. LVNC9 is an autosomal dominant condition.","diseaseCrossReference":{"database":"MIM","id":"611878"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21551322"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Incomplete sequence"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Tropomyosin alpha-1 chain","featureId":"PRO_0000205620"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3548719"}]},{"type":"Modified residue","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04692"}]},{"type":"Modified residue","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":174,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P58771"}]},{"type":"Modified residue","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P58771"}]},{"type":"Modified residue","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P58771"}]},{"type":"Modified residue","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04692"}]},{"type":"Modified residue","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P58771"}]},{"type":"Modified residue","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"Phosphoserine; by DAPK1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17895359"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3138425"}],"featureId":"VSP_006576","alternativeSequence":{"originalSequence":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATD","alternativeSequences":["MCRLRIFLRTASSEHLHERKLRET"]}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_017498","alternativeSequence":{"originalSequence":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATD","alternativeSequences":["MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRET"]}},{"type":"Alternative sequence","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"in isoform 6 and isoform 7","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15249230"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_036064","alternativeSequence":{"originalSequence":"DELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATD","alternativeSequences":["EDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAK"]}},{"type":"Alternative sequence","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"in isoform 8","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_047297","alternativeSequence":{"originalSequence":"DELVSLQKKLKGT","alternativeSequences":["EDIAAKEKLLRVS"]}},{"type":"Alternative sequence","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":80,"modifier":"EXACT"}},"description":"in isoform 8","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_047298","alternativeSequence":{"originalSequence":"LDKYSEALKDAQEKLELAEKKATD","alternativeSequences":["RDRVLEELHKAEDSLLAAEEAAAK"]}},{"type":"Alternative sequence","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3138425"}],"featureId":"VSP_006578","alternativeSequence":{"originalSequence":"KCAELEEELKTVTNNLKSLEAQAE","alternativeSequences":["QVRQLEEQLRIMDSDLESINAAED"]}},{"type":"Alternative sequence","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3336357"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3336363"}],"featureId":"VSP_006577","alternativeSequence":{"originalSequence":"KCAELEEELKTVTNNLKSLEAQAE","alternativeSequences":["QVRQLEEQLRIMDQTLKALMAAED"]}},{"type":"Alternative sequence","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in isoform 8 and isoform 10","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_047299","alternativeSequence":{"originalSequence":"KCAE","alternativeSequences":["QVRQ"]}},{"type":"Alternative sequence","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in isoform 8 and isoform 10","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_047300","alternativeSequence":{"originalSequence":"ELKTVTNNLKSLEAQAE","alternativeSequences":["QLRIMDQTLKALMAAED"]}},{"type":"Alternative sequence","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"in isoform 2, isoform 3, isoform 7, isoform 8 and isoform 9","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3138425"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3336357"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"3336363"}],"featureId":"VSP_006579","alternativeSequence":{"originalSequence":"DELYAQKLKYKAISEELDHALNDMTSI","alternativeSequences":["EKVAHAKEENLSMHQMLDQTLLELNNM"]}},{"type":"Alternative sequence","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_017499","alternativeSequence":{"originalSequence":"ELYAQKLKYKAISEELDHALNDMTSI","alternativeSequences":["QLYQQLEQNRRLTNELKLALNED"]}},{"type":"Alternative sequence","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"in isoform 10","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_047301","alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"in CMD1Y; dbSNP:rs104894501","featureCrossReferences":[{"database":"dbSNP","id":"rs104894501"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11273725"}],"featureId":"VAR_043986","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"in CMD1Y; dbSNP:rs104894505","featureCrossReferences":[{"database":"dbSNP","id":"rs104894505"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11273725"}],"featureId":"VAR_043987","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"in CMH3; dbSNP:rs199476306","featureCrossReferences":[{"database":"dbSNP","id":"rs199476306"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8523464"}],"featureId":"VAR_013135","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in CMH3; no change in homodimerization; no change in homodimer thermal stability; decreased actin binding; recessive effect in the homodimer; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer; dbSNP:rs104894503","featureCrossReferences":[{"database":"dbSNP","id":"rs104894503"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23170982"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7898523"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8205619"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8523464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9822100"}],"featureId":"VAR_007601","alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in CMH3; no change in homodimerization; decreased in hom odimer thermal stability; decreased in actin binding; increased calcium-dependent regulation of myosin binding to actin filaments; dominant effect in the homodimer; dbSNP:rs104894502","featureCrossReferences":[{"database":"dbSNP","id":"rs104894502"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23170982"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8205619"}],"featureId":"VAR_007602","alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":180,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"in CMH3; dbSNP:rs104894502","featureCrossReferences":[{"database":"dbSNP","id":"rs104894502"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12974739"}],"featureId":"VAR_029452","alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"in LVNC9; dbSNP:rs199476315","featureCrossReferences":[{"database":"dbSNP","id":"rs199476315"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21551322"}],"featureId":"VAR_070121","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in LVNC9; dbSNP:rs199476319","featureCrossReferences":[{"database":"dbSNP","id":"rs199476319"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21551322"}],"featureId":"VAR_070122","alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"Impairs interaction with LMOD2 and TMOD1.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26873245"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"Loss of phosphorylation and decreased formation of actin stress fibers.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17895359"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"Increased formation of actin stress fibers.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17895359"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in Ref. 11; CAA30930","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"in Ref. 4; AAT68294/AAT68295","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Helix","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5KHT"}]},{"type":"Helix","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8ZB7"}]},{"type":"Modified residue","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"},"sequence":"P09493-2"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"},"sequence":"P09493-3"},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"},"sequence":"P09493-4"},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"},"sequence":"P09493-5"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"},"sequence":"P09493-8"},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"},"sequence":"P09493-10"},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0122","category":"Disease","name":"Cardiomyopathy"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"3548719","citationType":"journal article","authors":["Mische S.M.","Manjula B.N.","Fischetti V.A."],"citationCrossReferences":[{"database":"PubMed","id":"3548719"},{"database":"DOI","id":"10.1016/0006-291x(87)91486-0"}],"title":"Relation of streptococcal M protein with human and rabbit tropomyosin: the complete amino acid sequence of human cardiac alpha tropomyosin, a highly conserved contractile protein.","publicationDate":"1987","journal":"Biochem. Biophys. Res. Commun.","firstPage":"813","lastPage":"818","volume":"142"},"referencePositions":["PROTEIN SEQUENCE (ISOFORM 1)","ACETYLATION AT MET-1"]},{"referenceNumber":2,"citation":{"id":"3336357","citationType":"journal article","authors":["Lin C.-S.","Leavitt J."],"citationCrossReferences":[{"database":"PubMed","id":"3336357"},{"database":"DOI","id":"10.1128/mcb.8.1.160-168.1988"}],"title":"Cloning and characterization of a cDNA encoding transformation-sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.","publicationDate":"1988","journal":"Mol. Cell. Biol.","firstPage":"160","lastPage":"168","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Fibroblast","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"3336363","citationType":"journal article","authors":["McLeod A.R.","Gooding C."],"citationCrossReferences":[{"database":"PubMed","id":"3336363"},{"database":"DOI","id":"10.1128/mcb.8.1.433-440.1988"}],"title":"Human hTM alpha gene: expression in muscle and nonmuscle tissue.","publicationDate":"1988","journal":"Mol. Cell. Biol.","firstPage":"433","lastPage":"440","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)"]},{"referenceNumber":4,"citation":{"id":"15249230","citationType":"journal article","authors":["Denz C.R.","Narshi A.","Zajdel R.W.","Dube D.K."],"citationCrossReferences":[{"database":"PubMed","id":"15249230"},{"database":"DOI","id":"10.1016/j.bbrc.2004.06.084"}],"title":"Expression of a novel cardiac-specific tropomyosin isoform in humans.","publicationDate":"2004","journal":"Biochem. Biophys. Res. Commun.","firstPage":"1291","lastPage":"1297","volume":"320"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 6)","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Heart","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Tongue","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"CI-C1NV2K4FQC878","citationType":"submission","authoringGroup":["NHLBI resequencing and genotyping service (RS&G)"],"publicationDate":"DEC-2009","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L. III","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.B.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":10,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Hippocampus","type":"TISSUE"},{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"3138425","citationType":"journal article","authors":["Colote S.","Widada J.S.","Ferraz C.","Bonhomme F.","Marti J.","Liautard J.-P."],"citationCrossReferences":[{"database":"PubMed","id":"3138425"},{"database":"DOI","id":"10.1007/bf02100079"}],"title":"Evolution of tropomyosin functional domains: differential splicing and genomic constraints.","publicationDate":"1988","journal":"J. Mol. Evol.","firstPage":"228","lastPage":"235","volume":"27"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 58-284 (ISOFORM 2)"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"8450225","citationType":"journal article","authors":["Das K.M.","Dasgupta A.","Mandal A.","Geng X."],"citationCrossReferences":[{"database":"PubMed","id":"8450225"},{"database":"DOI","id":"10.4049/jimmunol.150.6.2487"}],"title":"Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis.","publicationDate":"1993","journal":"J. Immunol.","firstPage":"2487","lastPage":"2493","volume":"150"},"referencePositions":["PROTEIN SEQUENCE OF 134-149 AND 153-167"],"referenceComments":[{"value":"Colon","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"11840567","citationType":"journal article","authors":["Harris R.A.","Yang A.","Stein R.C.","Lucy K.","Brusten L.","Herath A.","Parekh R.","Waterfield M.D.","O'Hare M.J.","Neville M.A.","Page M.J.","Zvelebil M.J."],"citationCrossReferences":[{"database":"PubMed","id":"11840567"},{"database":"DOI","id":"10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h"}],"title":"Cluster analysis of an extensive human breast cancer cell line protein expression map database.","publicationDate":"2002","journal":"Proteomics","firstPage":"212","lastPage":"223","volume":"2"},"referencePositions":["MASS SPECTROMETRY"],"referenceComments":[{"value":"Mammary cancer","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"17895359","citationType":"journal article","authors":["Houle F.","Poirier A.","Dumaresq J.","Huot J."],"citationCrossReferences":[{"database":"PubMed","id":"17895359"},{"database":"DOI","id":"10.1242/jcs.003251"}],"title":"DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress.","publicationDate":"2007","journal":"J. Cell Sci.","firstPage":"3666","lastPage":"3677","volume":"120"},"referencePositions":["PHOSPHORYLATION AT SER-283","MUTAGENESIS OF SER-283"]},{"referenceNumber":15,"citation":{"id":"CI-F67E8ML979GN9","citationType":"submission","authors":["Ahamed M.E."],"publicationDate":"APR-2007","submissionDatabase":"UniProtKB"},"referencePositions":["TISSUE SPECIFICITY","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":16,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-213 (ISOFORMS 10; 3; 4 AND 8)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"23170982","citationType":"journal article","authors":["Janco M.","Kalyva A.","Scellini B.","Piroddi N.","Tesi C.","Poggesi C.","Geeves M.A."],"citationCrossReferences":[{"database":"PubMed","id":"23170982"},{"database":"DOI","id":"10.1021/bi301323n"}],"title":"alpha-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains.","publicationDate":"2012","journal":"Biochemistry","firstPage":"9880","lastPage":"9890","volume":"51"},"referencePositions":["FUNCTION","CHARACTERIZATION OF VARIANTS CMH3 ASN-175 AND GLY-180","SUBUNIT"]},{"referenceNumber":20,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31 (ISOFORM 2)","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51 (ISOFORM 5)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":21,"citation":{"id":"26873245","citationType":"journal article","authors":["Colpan M.","Tolkatchev D.","Grover S.","Helms G.L.","Cort J.R.","Moroz N.","Kostyukova A.S."],"citationCrossReferences":[{"database":"PubMed","id":"26873245"},{"database":"DOI","id":"10.1016/j.bbapap.2016.02.009"}],"title":"Localization of the binding interface between leiomodin-2 and alpha-tropomyosin.","publicationDate":"2016","journal":"Biochim. Biophys. Acta","firstPage":"523","lastPage":"530","volume":"1864"},"referencePositions":["INTERACTION WITH LMOD2"]},{"referenceNumber":22,"citation":{"id":"8205619","citationType":"journal article","authors":["Thierfelder L.","Watkins H.","Macrae C.","Lamas R.","McKenna W.J.","Vosberg H.-P.","Seidman J.G.","Seidman C.E."],"citationCrossReferences":[{"database":"PubMed","id":"8205619"},{"database":"DOI","id":"10.1016/0092-8674(94)90054-x"}],"title":"Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere.","publicationDate":"1994","journal":"Cell","firstPage":"701","lastPage":"712","volume":"77"},"referencePositions":["VARIANTS CMH3 ASN-175 AND GLY-180"]},{"referenceNumber":23,"citation":{"id":"8523464","citationType":"journal article","authors":["Nakajima-Taniguchi C.","Matsui H.","Nagata S.","Kishimoto T.","Yamauchi-Takihara K."],"citationCrossReferences":[{"database":"PubMed","id":"8523464"},{"database":"DOI","id":"10.1016/0022-2828(95)90026-8"}],"title":"Novel missense mutation in alpha-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy.","publicationDate":"1995","journal":"J. Mol. Cell. Cardiol.","firstPage":"2053","lastPage":"2058","volume":"27"},"referencePositions":["VARIANTS CMH3 VAL-63 AND ASN-175"]},{"referenceNumber":24,"citation":{"id":"7898523","citationType":"journal article","authors":["Watkins H.","McKenna W.J.","Thierfelder L.","Suk H.J.","Anan R.","O'Donoghue A.","Spirito P.","Matsumori A.","Moravec C.S.","Seidman J.G.","Seidman C.E."],"citationCrossReferences":[{"database":"PubMed","id":"7898523"},{"database":"DOI","id":"10.1056/nejm199504203321603"}],"title":"Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy.","publicationDate":"1995","journal":"N. Engl. J. Med.","firstPage":"1058","lastPage":"1064","volume":"332"},"referencePositions":["VARIANT CMH3 ASN-175"]},{"referenceNumber":25,"citation":{"id":"9822100","citationType":"journal article","authors":["Jaeaeskelaeinen P.","Soranta M.","Miettinen R.","Saarinen L.","Pihlajamaeki J.","Silvennoinen K.","Tikanoja T.","Laakso M.","Kuusisto J."],"citationCrossReferences":[{"database":"PubMed","id":"9822100"},{"database":"DOI","id":"10.1016/s0735-1097(98)00448-3"}],"title":"The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population.","publicationDate":"1998","journal":"J. Am. Coll. Cardiol.","firstPage":"1709","lastPage":"1716","volume":"32"},"referencePositions":["VARIANT CMH3 ASN-175"]},{"referenceNumber":26,"citation":{"id":"11273725","citationType":"journal article","authors":["Olson T.M.","Kishimoto N.Y.","Whitby F.G.","Michels V.V."],"citationCrossReferences":[{"database":"PubMed","id":"11273725"},{"database":"DOI","id":"10.1006/jmcc.2000.1339"}],"title":"Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy.","publicationDate":"2001","journal":"J. Mol. Cell. Cardiol.","firstPage":"723","lastPage":"732","volume":"33"},"referencePositions":["VARIANTS CMD1Y LYS-40 AND LYS-54"]},{"referenceNumber":27,"citation":{"id":"12974739","citationType":"journal article","authors":["Erdmann J.","Daehmlow S.","Wischke S.","Senyuva M.","Werner U.","Raible J.","Tanis N.","Dyachenko S.","Hummel M.","Hetzer R.","Regitz-Zagrosek V."],"citationCrossReferences":[{"database":"PubMed","id":"12974739"},{"database":"DOI","id":"10.1034/j.1399-0004.2003.00151.x"}],"title":"Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy.","publicationDate":"2003","journal":"Clin. Genet.","firstPage":"339","lastPage":"349","volume":"64"},"referencePositions":["VARIANT CMH3 VAL-180"]},{"referenceNumber":28,"citation":{"id":"21551322","citationType":"journal article","authors":["Probst S.","Oechslin E.","Schuler P.","Greutmann M.","Boye P.","Knirsch W.","Berger F.","Thierfelder L.","Jenni R.","Klaassen S."],"citationCrossReferences":[{"database":"PubMed","id":"21551322"},{"database":"DOI","id":"10.1161/circgenetics.110.959270"}],"title":"Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype.","publicationDate":"2011","journal":"Circ. Cardiovasc. Genet.","firstPage":"367","lastPage":"374","volume":"4"},"referencePositions":["VARIANTS LVNC9 LYS-192 AND GLU-248"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M19267","properties":[{"key":"ProteinId","value":"AAA36771.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M19713","properties":[{"key":"ProteinId","value":"AAA61225.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M19714","properties":[{"key":"ProteinId","value":"AAA61226.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M19715","properties":[{"key":"ProteinId","value":"AAA61227.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY640414","properties":[{"key":"ProteinId","value":"AAT68294.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY640415","properties":[{"key":"ProteinId","value":"AAT68295.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK299387","properties":[{"key":"ProteinId","value":"BAH13023.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL050179","properties":[{"key":"ProteinId","value":"CAB43309.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"GU324929","properties":[{"key":"ProteinId","value":"ADL14500.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"GU324930","properties":[{"key":"ProteinId","value":"ADL14501.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"GU324933","properties":[{"key":"ProteinId","value":"ADL14504.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"GU324935","properties":[{"key":"ProteinId","value":"ADL14506.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471082","properties":[{"key":"ProteinId","value":"EAW77619.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471082","properties":[{"key":"ProteinId","value":"EAW77622.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471082","properties":[{"key":"ProteinId","value":"EAW77623.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471082","properties":[{"key":"ProteinId","value":"EAW77627.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471082","properties":[{"key":"ProteinId","value":"EAW77628.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC007433","properties":[{"key":"ProteinId","value":"AAH07433.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC050473","properties":[{"key":"ProteinId","value":"AAH50473.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC053545","properties":[{"key":"ProteinId","value":"AAH53545.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X12369","properties":[{"key":"ProteinId","value":"CAA30930.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS10181.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-10"},{"database":"CCDS","id":"CCDS32262.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-7"},{"database":"CCDS","id":"CCDS32263.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-3"},{"database":"CCDS","id":"CCDS32264.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-5"},{"database":"CCDS","id":"CCDS45273.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-1"},{"database":"CCDS","id":"CCDS58368.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-8"},{"database":"CCDS","id":"CCDS58369.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-9"},{"database":"CCDS","id":"CCDS86459.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-6"},{"database":"PIR","id":"A27674","properties":[{"key":"EntryName","value":"A27674"}]},{"database":"PIR","id":"A27678","properties":[{"key":"EntryName","value":"A25825"}]},{"database":"PIR","id":"S05585","properties":[{"key":"EntryName","value":"S05585"}]},{"database":"RefSeq","id":"NP_000357.3","properties":[{"key":"NucleotideSequenceId","value":"NM_000366.6"}],"isoformId":"P09493-10"},{"database":"RefSeq","id":"NP_001018004.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001018004.2"}],"isoformId":"P09493-9"},{"database":"RefSeq","id":"NP_001018005.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001018005.2"}],"isoformId":"P09493-1"},{"database":"RefSeq","id":"NP_001018006.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001018006.2"}],"isoformId":"P09493-3"},{"database":"RefSeq","id":"NP_001018007.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001018007.2"}],"isoformId":"P09493-7"},{"database":"RefSeq","id":"NP_001018008.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001018008.2"}],"isoformId":"P09493-5"},{"database":"RefSeq","id":"NP_001018020.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001018020.2"}],"isoformId":"P09493-8"},{"database":"RefSeq","id":"NP_001288173.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001301244.2"}],"isoformId":"P09493-6"},{"database":"RefSeq","id":"NP_001317273.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001330344.2"}]},{"database":"RefSeq","id":"NP_001317275.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001330346.2"}]},{"database":"RefSeq","id":"NP_001317280.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001330351.2"}]},{"database":"RefSeq","id":"NP_001394259.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407330.1"}],"isoformId":"P09493-10"},{"database":"RefSeq","id":"NP_001394260.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407331.1"}],"isoformId":"P09493-4"},{"database":"PDB","id":"3MUD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"C/D=1-29"}]},{"database":"PDB","id":"5KHT","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.50 A"},{"key":"Chains","value":"A/B/C/D=1-28"}]},{"database":"PDB","id":"6KN7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.60 A"},{"key":"Chains","value":"P/Q/W/X=11-284, R/S/Y/Z=1-29"}]},{"database":"PDB","id":"6KN8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.80 A"},{"key":"Chains","value":"P/Q/W/X=11-284, R/S/Y/Z=1-29"}]},{"database":"PDB","id":"6UT2","properties":[{"key":"Method","value":"NMR"},{"key":"Resolution","value":"-"},{"key":"Chains","value":"B/C=1-14"}]},{"database":"PDB","id":"6X5Z","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.24 A"},{"key":"Chains","value":"O/P=1-284"}]},{"database":"PDB","id":"7UTI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.80 A"},{"key":"Chains","value":"W/b/e/f/g/h/i/j=1-284"}]},{"database":"PDB","id":"7UTL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.60 A"},{"key":"Chains","value":"W/Z/a/b/g/h/i/j=1-284"}]},{"database":"PDB","id":"8EFH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"O/P=1-284"}]},{"database":"PDB","id":"8EFI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"O/P=1-284"}]},{"database":"PDB","id":"8ENC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"O/P=1-284"}]},{"database":"PDB","id":"8ZB7","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.19 A"},{"key":"Chains","value":"L/N/O/P=45-210"}]},{"database":"PDB","id":"9ZBL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.79 A"},{"key":"Chains","value":"M/N/O/P=1-284"}]},{"database":"PDB","id":"9ZBP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.12 A"},{"key":"Chains","value":"M/N/O/P=1-284"}]},{"database":"PDBsum","id":"3MUD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5KHT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KN7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KN8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6UT2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6X5Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UTI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UTL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8EFH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8EFI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ENC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8ZB7","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ZBL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9ZBP","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0728","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0729","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-22067","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-28082","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-28083","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-28270","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-39896","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-73993","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-73996","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"113021","properties":[{"key":"Interactions","value":"301"}]},{"database":"FunCoup","id":"P09493","properties":[{"key":"Number of interactors","value":"635"}]},{"database":"IntAct","id":"P09493","properties":[{"key":"Interactions","value":"125"}]},{"database":"MINT","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-TPM1","properties":[{"key":"Evidences","value":"6 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000351022","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4295705","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB11638","properties":[{"key":"GenericName","value":"Artenimol"}]},{"database":"DrugBank","id":"DB12695","properties":[{"key":"GenericName","value":"Phenethyl Isothiocyanate"}]},{"database":"GlyGen","id":"P09493","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TPM1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"136092","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1462","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1463","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1464","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000351022","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"15181","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"15182","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"15183","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52229","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-1"},{"database":"ProteomicsDB","id":"52230","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-2"},{"database":"ProteomicsDB","id":"52231","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-3"},{"database":"ProteomicsDB","id":"52232","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-4"},{"database":"ProteomicsDB","id":"52233","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-5"},{"database":"ProteomicsDB","id":"52234","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-6"},{"database":"ProteomicsDB","id":"52235","properties":[{"key":"Description","value":"-"}],"isoformId":"P09493-7"},{"database":"Pumba","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"635","properties":[{"key":"antibodies","value":"344 antibodies from 42 providers"}]},{"database":"DNASU","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000267996.11","properties":[{"key":"ProteinId","value":"ENSP00000267996.7"},{"key":"GeneId","value":"ENSG00000140416.27"}],"isoformId":"P09493-7"},{"database":"Ensembl","id":"ENST00000288398.10","properties":[{"key":"ProteinId","value":"ENSP00000288398.6"},{"key":"GeneId","value":"ENSG00000140416.27"}],"isoformId":"P09493-10"},{"database":"Ensembl","id":"ENST00000334895.10","properties":[{"key":"ProteinId","value":"ENSP00000334624.4"},{"key":"GeneId","value":"ENSG00000140416.27"}],"isoformId":"P09493-5"},{"database":"Ensembl","id":"ENST00000358278.7","properties":[{"key":"ProteinId","value":"ENSP00000351022.3"},{"key":"GeneId","value":"ENSG00000140416.27"}],"isoformId":"P09493-3"},{"database":"Ensembl","id":"ENST00000403994.9","properties":[{"key":"ProteinId","value":"ENSP00000385107.4"},{"key":"GeneId","value":"ENSG00000140416.27"}],"isoformId":"P09493-1"},{"database":"Ensembl","id":"ENST00000559397.6","properties":[{"key":"ProteinId","value":"ENSP00000452879.1"},{"key":"GeneId","value":"ENSG00000140416.27"}],"isoformId":"P09493-8"},{"database":"Ensembl","id":"ENST00000559556.5","properties":[{"key":"ProteinId","value":"ENSP00000453941.1"},{"key":"GeneId","value":"ENSG00000140416.27"}],"isoformId":"P09493-9"},{"database":"Ensembl","id":"ENST00000561266.6","properties":[{"key":"ProteinId","value":"ENSP00000453955.2"},{"key":"GeneId","value":"ENSG00000140416.27"}],"isoformId":"P09493-6"},{"database":"Ensembl","id":"ENST00000893958.1","properties":[{"key":"ProteinId","value":"ENSP00000564017.1"},{"key":"GeneId","value":"ENSG00000140416.27"}],"isoformId":"P09493-4"},{"database":"GeneID","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:7168","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000403994.9","properties":[{"key":"ProteinId","value":"ENSP00000385107.4"},{"key":"RefSeqNucleotideId","value":"NM_001018005.2"},{"key":"RefSeqProteinId","value":"NP_001018005.1"}]},{"database":"UCSC","id":"uc002alg.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P09493-1"},{"database":"AGR","id":"HGNC:12010","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA36690","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TPM1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"TPM1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"HPA","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (heart muscle, skeletal muscle)"}]},{"database":"MalaCards","id":"TPM1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"115196","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"191010","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"611878","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"154","properties":[{"key":"Disease","value":"Familial isolated dilated cardiomyopathy"}]},{"database":"Orphanet","id":"54260","properties":[{"key":"Disease","value":"Left ventricular noncompaction"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_055027_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P09493","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-390522","properties":[{"key":"PathwayName","value":"Striated Muscle Contraction"}]},{"database":"Reactome","id":"R-HSA-445355","properties":[{"key":"PathwayName","value":"Smooth Muscle Contraction"}]},{"database":"SignaLink","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P09493","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000140416","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"7168","properties":[{"key":"hits","value":"14 hits in 1165 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"TPM1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P09493","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P09493","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"RNAct","id":"P09493","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P09493","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005884","properties":[{"key":"GoTerm","value":"C:actin filament"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032059","properties":[{"key":"GoTerm","value":"C:bleb"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12686598"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16130169"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005862","properties":[{"key":"GoTerm","value":"C:muscle thin filament tropomyosin"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8205619"}]},{"database":"GO","id":"GO:0032587","properties":[{"key":"GoTerm","value":"C:ruffle membrane"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12686598"}]},{"database":"GO","id":"GO:0030017","properties":[{"key":"GoTerm","value":"C:sarcomere"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16754800"}]},{"database":"GO","id":"GO:0001725","properties":[{"key":"GoTerm","value":"C:stress fiber"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12686598"}]},{"database":"GO","id":"GO:0003779","properties":[{"key":"GoTerm","value":"F:actin binding"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"12686598"}]},{"database":"GO","id":"GO:0051015","properties":[{"key":"GoTerm","value":"F:actin filament binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008092","properties":[{"key":"GoTerm","value":"F:cytoskeletal protein binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17987659"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005200","properties":[{"key":"GoTerm","value":"F:structural constituent of cytoskeleton"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"12686598"}]},{"database":"GO","id":"GO:0008307","properties":[{"key":"GoTerm","value":"F:structural constituent of muscle"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8205619"}]},{"database":"GO","id":"GO:0007015","properties":[{"key":"GoTerm","value":"P:actin filament organization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0060048","properties":[{"key":"GoTerm","value":"P:cardiac muscle contraction"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11136687"}]},{"database":"GO","id":"GO:0034614","properties":[{"key":"GoTerm","value":"P:cellular response to reactive oxygen species"},{"key":"GoEvidenceType","value":"IEP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"12686598"}]},{"database":"GO","id":"GO:0007010","properties":[{"key":"GoTerm","value":"P:cytoskeleton organization"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"12686598"}]},{"database":"GO","id":"GO:0030049","properties":[{"key":"GoTerm","value":"P:muscle filament sliding"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"11136687"}]},{"database":"GO","id":"GO:0030336","properties":[{"key":"GoTerm","value":"P:negative regulation of cell migration"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"15897890"}]},{"database":"GO","id":"GO:1904753","properties":[{"key":"GoTerm","value":"P:negative regulation of vascular associated smooth muscle cell migration"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21817107"}]},{"database":"GO","id":"GO:1904706","properties":[{"key":"GoTerm","value":"P:negative regulation of vascular associated smooth muscle cell proliferation"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21817107"}]},{"database":"GO","id":"GO:0045785","properties":[{"key":"GoTerm","value":"P:positive regulation of cell adhesion"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"17721995"}]},{"database":"GO","id":"GO:0003065","properties":[{"key":"GoTerm","value":"P:positive regulation of heart rate by epinephrine"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"17556658"}]},{"database":"GO","id":"GO:0051496","properties":[{"key":"GoTerm","value":"P:positive regulation of stress fiber assembly"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"15897890"}]},{"database":"GO","id":"GO:0008360","properties":[{"key":"GoTerm","value":"P:regulation of cell shape"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21817107"}]},{"database":"GO","id":"GO:0008016","properties":[{"key":"GoTerm","value":"P:regulation of heart contraction"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8205619"}]},{"database":"GO","id":"GO:0006937","properties":[{"key":"GoTerm","value":"P:regulation of muscle contraction"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"3336363"}]},{"database":"GO","id":"GO:0031529","properties":[{"key":"GoTerm","value":"P:ruffle organization"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"15897890"}]},{"database":"GO","id":"GO:0045214","properties":[{"key":"GoTerm","value":"P:sarcomere organization"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11273725"}]},{"database":"GO","id":"GO:0055010","properties":[{"key":"GoTerm","value":"P:ventricular cardiac muscle tissue morphogenesis"},{"key":"GoEvidenceType","value":"IMP:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"11136687"}]},{"database":"GO","id":"GO:0042060","properties":[{"key":"GoTerm","value":"P:wound healing"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"17721995"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI","length":284,"molWeight":32709,"crc64":"F57139E2B0972F4D","md5":"D1DB59BC86C4AD2D189DF97DCFB8F0B2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":28,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":10,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":1,"MASS SPECTROMETRY":1,"DISEASE":3,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Coiled coil":1,"Compositional bias":1,"Modified residue":15,"Alternative sequence":12,"Natural variant":8,"Mutagenesis":3,"Sequence conflict":2,"Helix":2},"uniParcId":"UPI0000040637"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A494C0V8","uniProtkbId":"A0A494C0V8_HUMAN","entryAudit":{"firstPublicDate":"2019-06-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":38,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498730.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498730.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498730.1"}],"value":"TPM1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Coiled coil","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A494C0V8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A494C0V8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498730.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498730.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498730.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000498730.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A494C0V8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A494C0V8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"635","properties":[{"key":"antibodies","value":"344 antibodies from 42 providers"}]},{"database":"Ensembl","id":"ENST00000651577.1","properties":[{"key":"ProteinId","value":"ENSP00000498730.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"Ensembl","id":"ENST00000651704.1","properties":[{"key":"ProteinId","value":"ENSP00000498562.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDQLYQQLEQNRRLTNELKLALNED","length":155,"molWeight":18245,"crc64":"6E7FD1B09233A02E","md5":"C5CB09F29DE7F80100394D7162F28578"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Coiled coil":1},"uniParcId":"UPI00108CBA1B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAQ5BH66","uniProtkbId":"A0AAQ5BH66_HUMAN","entryAudit":{"firstPublicDate":"2024-10-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-10-02","entryVersion":9,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519306.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519306.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519306.1"}],"value":"TPM1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0AAQ5BH66"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0AAQ5BH66"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519306.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519306.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519306.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519306.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAQ5BH66","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0AAQ5BH66","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000714016.1","properties":[{"key":"ProteinId","value":"ENSP00000519306.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDFPVCKVWIVTASTCRLKELLCKDSTLMLGAKGLKPT","length":116,"molWeight":13086,"crc64":"F7F382D98C8D7FB5","md5":"4B0ACCCEBF585649A6A2D0EBD3CCFEB7"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":1},"uniParcId":"UPI0032C5224C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RK85","uniProtkbId":"A0ACI8RK85_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564019.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564019.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564019.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Coils"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RK85"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RK85"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564019.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564019.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564019.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000564019.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000893960.1","properties":[{"key":"ProteinId","value":"ENSP00000564019.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000161","properties":[{"key":"EntryName","value":"Tropomyosin 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVRSWGPKPCGHPAVAFRKPGSNVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI","length":306,"molWeight":35039,"crc64":"4F2713F1B8856A05","md5":"82A9AEF04A5E03295EC99F2052E79532"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Coiled coil":1,"Compositional bias":1},"uniParcId":"UPI004031D59D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U5N0","uniProtkbId":"A0ACI8U5N0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612132.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612132.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612132.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U5N0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U5N0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612132.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612132.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612132.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612132.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000942073.1","properties":[{"key":"ProteinId","value":"ENSP00000612132.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.1160","properties":[{"key":"EntryName","value":"Vasodilator-stimulated phosphoprotein"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI","length":242,"molWeight":27933,"crc64":"D29DA89A49E2FD29","md5":"DFC5FBBA42A9A1D710EACEAFEDD85FD7"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI0003E69ACB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U5P0","uniProtkbId":"A0ACI8U5P0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612129.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612129.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612129.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U5P0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U5P0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612129.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612129.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612129.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612129.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000942070.1","properties":[{"key":"ProteinId","value":"ENSP00000612129.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI","length":282,"molWeight":32508,"crc64":"45B485CC99A9618D","md5":"CBF86C11DB12CE52885505D94F651B49"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI0040321470"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B7Z722","uniProtkbId":"B7Z722_HUMAN","entryAudit":{"firstPublicDate":"2009-03-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-03-03","entryVersion":90,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAH13458.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW77629.1"}],"value":"Tropomyosin 1 (Alpha), isoform CRA_i"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAH13458.1"}],"value":"cDNA FLJ54760, highly similar to Rattus norvegicus tropomyosin 1, alpha (Tpm1), transcript variant 7, mRNA"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW77629.1"}],"value":"TPM1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW77629.1"}],"value":"hCG_33495"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW77629.1"}]},{"referenceNumber":2,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW77629.1"}]},{"referenceNumber":3,"citation":{"id":"CI-2ELFNBL2J9UAG","citationType":"submission","authors":["Wakamatsu A.","Yamamoto J.","Kimura K.","Ishii S.","Watanabe K.","Sugiyama A.","Murakawa K.","Kaida T.","Tsuchiya K.","Fukuzumi Y.","Kumagai A.","Oishi Y.","Yamamoto S.","Ono Y.","Komori Y.","Yamazaki M.","Kisu Y.","Nishikawa T.","Sugano S.","Nomura N.","Isogai T."],"title":"NEDO human cDNA sequencing project focused on splicing variants.","publicationDate":"OCT-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAH13458.1"}],"value":"Stomach","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAH13458.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK301319","properties":[{"key":"ProteinId","value":"BAH13458.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471082","properties":[{"key":"ProteinId","value":"EAW77629.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001288218.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001301289.2"}]},{"database":"AlphaFoldDB","id":"B7Z722","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"B7Z722","properties":[{"key":"Description","value":"-"}]},{"database":"IntAct","id":"B7Z722","properties":[{"key":"Interactions","value":"1"}]},{"database":"PeptideAtlas","id":"B7Z722","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"7168","properties":[{"key":"hits","value":"14 hits in 1165 CRISPR screens"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005856","properties":[{"key":"GoTerm","value":"C:cytoskeleton"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.370:FF:000004","properties":[{"key":"EntryName","value":"tropomyosin alpha-1 chain isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.370","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"InterPro","id":"IPR014751","properties":[{"key":"EntryName","value":"XRCC4-like_C"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM","length":248,"molWeight":28608,"crc64":"A175BDD53107B563","md5":"5C662F0B362B43769F00F46DD69144F7"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI0000EE513F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F6UI89","uniProtkbId":"F6UI89_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000350667.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000350667.4"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000350667.4"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022990"}],"id":"KW-0007","category":"PTM","name":"Acetylation"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F6UI89"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"F6UI89"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000350667.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000350667.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000350667.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"18669648"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000350667.4"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001352707.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001365778.1"}]},{"database":"Ensembl","id":"ENST00000357980.9","properties":[{"key":"ProteinId","value":"ENSP00000350667.4"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"GeneID","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HHARESE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"7168","properties":[{"key":"hits","value":"14 hits in 1165 CRISPR screens"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000032","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.370:FF:000004","properties":[{"key":"EntryName","value":"tropomyosin alpha-1 chain isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.370","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.1160","properties":[{"key":"EntryName","value":"Vasodilator-stimulated phosphoprotein"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"InterPro","id":"IPR014751","properties":[{"key":"EntryName","value":"XRCC4-like_C"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM","length":326,"molWeight":37453,"crc64":"B7FADB9BB1508DD9","md5":"9FC24B2B7B7B8A9959DF20C1901DAC9C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2},"uniParcId":"UPI000035E7A6"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YKP3","uniProtkbId":"H0YKP3_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":69,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452887.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452887.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452887.1"}],"value":"TPM1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YKP3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YKP3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452887.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452887.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452887.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000452887.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H0YKP3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H0YKP3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H0YKP3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"39714","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000558347.5","properties":[{"key":"ProteinId","value":"ENSP00000452887.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"UCSC","id":"uc059kav.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_141705_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YKP3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERWPVSWSSLRATWNVQRSGLSSQKAKSDSWKNN","length":157,"molWeight":17904,"crc64":"CB10F5A571562D73","md5":"ACFD3065DA0A038AC219558D33D6E1D3"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI0000D4EAA7"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YLS7","uniProtkbId":"H0YLS7_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-02-22","entryVersion":70,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453324.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453324.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453324.1"}],"value":"TPM1"}}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YLS7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YLS7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453324.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453324.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453324.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453324.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H0YLS7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H0YLS7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H0YLS7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"40043","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000561425.5","properties":[{"key":"ProteinId","value":"ENSP00000453324.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"UCSC","id":"uc059kat.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_217782_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YLS7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.1160","properties":[{"key":"EntryName","value":"Vasodilator-stimulated phosphoprotein"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQWT","length":40,"molWeight":4664,"crc64":"97DAA1A486A6C351","md5":"5B554440BE4F373981E9BD657172DDDB"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI00022F85DA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A087WTJ7","uniProtkbId":"A0A087WTJ7_HUMAN","entryAudit":{"firstPublicDate":"2014-10-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2014-10-29","entryVersion":58,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000477929.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000477929.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000477929.1"}],"value":"TPM1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A087WTJ7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A087WTJ7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000477929.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000477929.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000477929.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000477929.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A087WTJ7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A087WTJ7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A087WTJ7","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"635","properties":[{"key":"antibodies","value":"344 antibodies from 42 providers"}]},{"database":"Ensembl","id":"ENST00000610733.1","properties":[{"key":"ProteinId","value":"ENSP00000477929.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"UCSC","id":"uc059kar.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_141705_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A087WTJ7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDVSARSHCFPHLLPAWPLRGHHRAGEQ","length":106,"molWeight":12095,"crc64":"EF730FE22A1B8AEE","md5":"E264058207000B450DE83CC2FC972426"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI0001EE4958"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0K0K1I0","uniProtkbId":"A0A0K0K1I0_HUMAN","entryAudit":{"firstPublicDate":"2015-11-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2015-11-11","entryVersion":69,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACV87173.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACV87173.1"}],"value":"Epididymis secretory protein Li 265"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALQ33824.1"}],"value":"Tropomyosin 1 isoform 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACV87173.1"}],"value":"HEL-S-265"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALQ33824.1"}],"value":"TPM1"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-ECFD08P7NAO5S","citationType":"submission","authors":["Sahoo P."],"publicationDate":"AUG-2009","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ACV87173.1"}]},{"referenceNumber":2,"citation":{"id":"26871637","citationType":"journal article","authors":["Yang X.","Coulombe-Huntington J.","Kang S.","Sheynkman G.M.","Hao T.","Richardson A.","Sun S.","Yang F.","Shen Y.A.","Murray R.","Spirohn K.","Begg B.E.","Duran-Frigola M.","MacWilliams A.","Pevzner S.J.","Zhong Q.","Trigg S.A.","Tam S.","Ghamsari L.","Sahni N.","Yi S.","Rodriguez M.D.","Balcha D.","Tan G.","Costanzo M.","Andrews B.","Boone C.","Zhou X.J.","Salehi-Ashtiani K.","Charloteaux B.","Chen A.","Calderwood M.A.","Aloy P.","Roth F.P.","Hill D.E.","Iakoucheva L.M.","Xia Y.","Vidal M."],"citationCrossReferences":[{"database":"PubMed","id":"26871637"},{"database":"DOI","id":"10.1016/j.cell.2016.01.029"}],"title":"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.","publicationDate":"2016","journal":"Cell","firstPage":"805","lastPage":"817","volume":"164"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALQ33824.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"GQ472198","properties":[{"key":"ProteinId","value":"ACV87173.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"KU178366","properties":[{"key":"ProteinId","value":"ALQ33824.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_000357.3","properties":[{"key":"NucleotideSequenceId","value":"NM_000366.6"}]},{"database":"AlphaFoldDB","id":"A0A0K0K1I0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0K0K1I0","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"635","properties":[{"key":"antibodies","value":"344 antibodies from 42 providers"}]},{"database":"DNASU","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"7168","properties":[{"key":"hits","value":"14 hits in 1165 CRISPR screens"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"ExpressionAtlas","id":"A0A0K0K1I0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005862","properties":[{"key":"GoTerm","value":"C:muscle thin filament tropomyosin"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM","length":284,"molWeight":32866,"crc64":"D45DBCA97BC3C6EE","md5":"F49E56475F29677EDF9A43BF9A57989D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI0000167927"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0S2Z4G6","secondaryAccessions":["H0YL52"],"uniProtkbId":"A0A0S2Z4G6_HUMAN","entryAudit":{"firstPublicDate":"2016-02-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-02-17","entryVersion":53,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALQ33825.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW77635.1"}],"value":"Tropomyosin 1 (Alpha), isoform CRA_o"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALQ33825.1"}],"value":"Tropomyosin 1 isoform 2"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALQ33825.1"}],"value":"TPM1"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW77635.1"}],"value":"hCG_33495"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALQ33825.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"}],"references":[{"referenceNumber":1,"citation":{"id":"11181995","citationType":"journal article","authors":["Venter J.C.","Adams M.D.","Myers E.W.","Li P.W.","Mural R.J.","Sutton G.G.","Smith H.O.","Yandell M.","Evans C.A.","Holt R.A.","Gocayne J.D.","Amanatides P.","Ballew R.M.","Huson D.H.","Wortman J.R.","Zhang Q.","Kodira C.D.","Zheng X.H.","Chen L.","Skupski M.","Subramanian G.","Thomas P.D.","Zhang J.","Gabor Miklos G.L.","Nelson C.","Broder S.","Clark A.G.","Nadeau J.","McKusick V.A.","Zinder N.","Levine A.J.","Roberts R.J.","Simon M.","Slayman C.","Hunkapiller M.","Bolanos R.","Delcher A.","Dew I.","Fasulo D.","Flanigan M.","Florea L.","Halpern A.","Hannenhalli S.","Kravitz S.","Levy S.","Mobarry C.","Reinert K.","Remington K.","Abu-Threideh J.","Beasley E.","Biddick K.","Bonazzi V.","Brandon R.","Cargill M.","Chandramouliswaran I.","Charlab R.","Chaturvedi K.","Deng Z.","Di Francesco V.","Dunn P.","Eilbeck K.","Evangelista C.","Gabrielian A.E.","Gan W.","Ge W.","Gong F.","Gu Z.","Guan P.","Heiman T.J.","Higgins M.E.","Ji R.R.","Ke Z.","Ketchum K.A.","Lai Z.","Lei Y.","Li Z.","Li J.","Liang Y.","Lin X.","Lu F.","Merkulov G.V.","Milshina N.","Moore H.M.","Naik A.K.","Narayan V.A.","Neelam B.","Nusskern D.","Rusch D.B.","Salzberg S.","Shao W.","Shue B.","Sun J.","Wang Z.","Wang A.","Wang X.","Wang J.","Wei M.","Wides R.","Xiao C.","Yan C.","Yao A.","Ye J.","Zhan M.","Zhang W.","Zhang H.","Zhao Q.","Zheng L.","Zhong F.","Zhong W.","Zhu S.","Zhao S.","Gilbert D.","Baumhueter S.","Spier G.","Carter C.","Cravchik A.","Woodage T.","Ali F.","An H.","Awe A.","Baldwin D.","Baden H.","Barnstead M.","Barrow I.","Beeson K.","Busam D.","Carver A.","Center A.","Cheng M.L.","Curry L.","Danaher S.","Davenport L.","Desilets R.","Dietz S.","Dodson K.","Doup L.","Ferriera S.","Garg N.","Gluecksmann A.","Hart B.","Haynes J.","Haynes C.","Heiner C.","Hladun S.","Hostin D.","Houck J.","Howland T.","Ibegwam C.","Johnson J.","Kalush F.","Kline L.","Koduru S.","Love A.","Mann F.","May D.","McCawley S.","McIntosh T.","McMullen I.","Moy M.","Moy L.","Murphy B.","Nelson K.","Pfannkoch C.","Pratts E.","Puri V.","Qureshi H.","Reardon M.","Rodriguez R.","Rogers Y.H.","Romblad D.","Ruhfel B.","Scott R.","Sitter C.","Smallwood M.","Stewart E.","Strong R.","Suh E.","Thomas R.","Tint N.N.","Tse S.","Vech C.","Wang G.","Wetter J.","Williams S.","Williams M.","Windsor S.","Winn-Deen E.","Wolfe K.","Zaveri J.","Zaveri K.","Abril J.F.","Guigo R.","Campbell M.J.","Sjolander K.V.","Karlak B.","Kejariwal A.","Mi H.","Lazareva B.","Hatton T.","Narechania A.","Diemer K.","Muruganujan A.","Guo N.","Sato S.","Bafna V.","Istrail S.","Lippert R.","Schwartz R.","Walenz B.","Yooseph S.","Allen D.","Basu A.","Baxendale J.","Blick L.","Caminha M.","Carnes-Stine J.","Caulk P.","Chiang Y.H.","Coyne M.","Dahlke C.","Mays A.","Dombroski M.","Donnelly M.","Ely D.","Esparham S.","Fosler C.","Gire H.","Glanowski S.","Glasser K.","Glodek A.","Gorokhov M.","Graham K.","Gropman B.","Harris M.","Heil J.","Henderson S.","Hoover J.","Jennings D.","Jordan C.","Jordan J.","Kasha J.","Kagan L.","Kraft C.","Levitsky A.","Lewis M.","Liu X.","Lopez J.","Ma D.","Majoros W.","McDaniel J.","Murphy S.","Newman M.","Nguyen T.","Nguyen N.","Nodell M.","Pan S.","Peck J.","Peterson M.","Rowe W.","Sanders R.","Scott J.","Simpson M.","Smith T.","Sprague A.","Stockwell T.","Turner R.","Venter E.","Wang M.","Wen M.","Wu D.","Wu M.","Xia A.","Zandieh A.","Zhu X."],"citationCrossReferences":[{"database":"PubMed","id":"11181995"},{"database":"DOI","id":"10.1126/science.1058040"}],"title":"The sequence of the human genome.","publicationDate":"2001","journal":"Science","firstPage":"1304","lastPage":"1351","volume":"291"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW77635.1"}]},{"referenceNumber":2,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"EAW77635.1"}]},{"referenceNumber":3,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":4,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":5,"citation":{"id":"26871637","citationType":"journal article","authors":["Yang X.","Coulombe-Huntington J.","Kang S.","Sheynkman G.M.","Hao T.","Richardson A.","Sun S.","Yang F.","Shen Y.A.","Murray R.","Spirohn K.","Begg B.E.","Duran-Frigola M.","MacWilliams A.","Pevzner S.J.","Zhong Q.","Trigg S.A.","Tam S.","Ghamsari L.","Sahni N.","Yi S.","Rodriguez M.D.","Balcha D.","Tan G.","Costanzo M.","Andrews B.","Boone C.","Zhou X.J.","Salehi-Ashtiani K.","Charloteaux B.","Chen A.","Calderwood M.A.","Aloy P.","Roth F.P.","Hill D.E.","Iakoucheva L.M.","Xia Y.","Vidal M."],"citationCrossReferences":[{"database":"PubMed","id":"26871637"},{"database":"DOI","id":"10.1016/j.cell.2016.01.029"}],"title":"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.","publicationDate":"2016","journal":"Cell","firstPage":"805","lastPage":"817","volume":"164"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALQ33825.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KU178367","properties":[{"key":"ProteinId","value":"ALQ33825.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471082","properties":[{"key":"ProteinId","value":"EAW77635.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001352708.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001365779.1"}]},{"database":"RefSeq","id":"NP_001394262.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407333.1"}]},{"database":"AlphaFoldDB","id":"A0A0S2Z4G6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A0S2Z4G6","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"635","properties":[{"key":"antibodies","value":"344 antibodies from 42 providers"}]},{"database":"GeneID","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc059kaw.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"GO","id":"GO:0005862","properties":[{"key":"GoTerm","value":"C:muscle thin filament tropomyosin"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM","length":284,"molWeight":32727,"crc64":"F3B139E2B0972F4D","md5":"5849CE88298297C7C7227150DAD7B111"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1,"Non-terminal residue":1},"uniParcId":"UPI00001400B4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0AAQ5BH95","uniProtkbId":"A0AAQ5BH95_HUMAN","entryAudit":{"firstPublicDate":"2024-10-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-10-02","entryVersion":9,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519305.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519305.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519305.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0AAQ5BH95"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0AAQ5BH95"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519305.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519305.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519305.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000519305.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0AAQ5BH95","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0AAQ5BH95","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000714015.1","properties":[{"key":"ProteinId","value":"ENSP00000519305.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"GO","id":"GO:0005862","properties":[{"key":"GoTerm","value":"C:muscle thin filament tropomyosin"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEEPIFFQV","length":265,"molWeight":30577,"crc64":"B349DF4E8547B04C","md5":"B29D6A88C2CEA0CA573DB1E7296FF4D8"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI0032D11984"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U5N1","uniProtkbId":"A0ACI8U5N1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612133.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612133.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612133.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U5N1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U5N1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612133.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612133.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612133.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612133.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000942074.1","properties":[{"key":"ProteinId","value":"ENSP00000612133.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDVTDVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI","length":283,"molWeight":32638,"crc64":"E4FDBBA09B8DA5DA","md5":"DD244B978F6FA085CC28E3B641A1F0F6"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2},"uniParcId":"UPI004032675C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U5R8","uniProtkbId":"A0ACI8U5R8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612128.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612128.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612128.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U5R8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U5R8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612128.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612128.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612128.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612128.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000942069.1","properties":[{"key":"ProteinId","value":"ENSP00000612128.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI","length":281,"molWeight":32366,"crc64":"710909D62835EF87","md5":"80F94CA50D9C911FFF7A6087443B6427"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI0040321845"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U668","uniProtkbId":"A0ACI8U668_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612136.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612136.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612136.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U668"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U668"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612136.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612136.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612136.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612136.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000942077.1","properties":[{"key":"ProteinId","value":"ENSP00000612136.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI","length":263,"molWeight":30097,"crc64":"A34AFDB47B0E6A4F","md5":"CBFDD8FA9A0CC08DA280B225681ABD76"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI004031CC90"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YL80","uniProtkbId":"H0YL80_HUMAN","entryAudit":{"firstPublicDate":"2012-02-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-01-24","entryVersion":72,"sequenceVersion":2},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453092.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453092.2"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453092.2"}],"value":"TPM1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YL80"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YL80"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453092.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453092.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453092.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453092.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"H0YL80","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"H0YL80","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"H0YL80","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"39873","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000561395.6","properties":[{"key":"ProteinId","value":"ENSP00000453092.2"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"UCSC","id":"uc059kbg.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_055027_5_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"H0YL80","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEQMCRA","length":155,"molWeight":17792,"crc64":"5C9650E043CB2906","md5":"E7545FD26D4DC2699F35EDAAFF56CE60"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI002644EE6C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U2A9","uniProtkbId":"A0ACI8U2A9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610234.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610234.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610234.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U2A9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U2A9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610234.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610234.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610234.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610234.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000940175.1","properties":[{"key":"ProteinId","value":"ENSP00000610234.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEG","length":188,"molWeight":21554,"crc64":"10D125E392BAB2B6","md5":"D514B856E92A71CDB2B9C8800ED17D50"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI0001548E66"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U331","uniProtkbId":"A0ACI8U331_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610236.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610236.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610236.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U331"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U331"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610236.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610236.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610236.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000610236.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000940177.1","properties":[{"key":"ProteinId","value":"ENSP00000610236.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.1160","properties":[{"key":"EntryName","value":"Vasodilator-stimulated phosphoprotein"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEG","length":146,"molWeight":16779,"crc64":"34D655AF3F4133E4","md5":"84A1F7BF9F49FE48B493C9F1BB47156B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI0040321C4A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U5R3","uniProtkbId":"A0ACI8U5R3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612131.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612131.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612131.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U5R3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U5R3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612131.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612131.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612131.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612131.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000942072.1","properties":[{"key":"ProteinId","value":"ENSP00000612131.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI","length":316,"molWeight":36269,"crc64":"26F26B1CB0B0902C","md5":"78F927B78F91FA00668DFEADC95991DA"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI0000E23D1A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U6M6","uniProtkbId":"A0ACI8U6M6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612137.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612137.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612137.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U6M6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U6M6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612137.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612137.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612137.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612137.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000942078.1","properties":[{"key":"ProteinId","value":"ENSP00000612137.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAER","length":244,"molWeight":28128,"crc64":"EF67B091E6B3A6B6","md5":"29A92774ACEE689E4456DE3D184070E0"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI0040323A4C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8U7P7","uniProtkbId":"A0ACI8U7P7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612139.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612139.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612139.1"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8U7P7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8U7P7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612139.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612139.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612139.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000612139.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000942080.1","properties":[{"key":"ProteinId","value":"ENSP00000612139.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI","length":280,"molWeight":32143,"crc64":"2C175DAB44732D06","md5":"BB6CA2888277B5426F0CEAF381539016"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2},"uniParcId":"UPI0040319DCF"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACM8QBN9","uniProtkbId":"A0ACM8QBN9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453062.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453062.2"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453062.2"}],"value":"TPM1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004245"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023212"}],"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACM8QBN9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACM8QBN9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453062.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453062.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453062.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453062.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001352708.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001365779.1"}]},{"database":"RefSeq","id":"NP_001394262.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407333.1"}]},{"database":"Ensembl","id":"ENST00000560970.6","properties":[{"key":"ProteinId","value":"ENSP00000453062.2"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"GeneID","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"FunFam","id":"1.20.5.1160:FF:000013","properties":[{"key":"EntryName","value":"Tropomyosin 1 (alpha)"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000005","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.340:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM","length":284,"molWeight":32727,"crc64":"F3B139E2B0972F4D","md5":"5849CE88298297C7C7227150DAD7B111"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":1},"uniParcId":"UPI00001400B4"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"H0YMS6","uniProtkbId":"H0YMS6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453724.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453724.1"}],"value":"Tropomyosin 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453724.1"}],"value":"TPM1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009036"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU004515"}],"value":"Belongs to the tropomyosin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Region","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023203"}],"id":"KW-0009","category":"Molecular function","name":"Actin-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023179"}],"id":"KW-0514","category":"Molecular function","name":"Muscle protein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"H0YMS6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"H0YMS6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453724.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453724.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L.III.","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453724.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"19608861"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":6,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000453724.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079328","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001394269.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407340.1"}]},{"database":"DNASU","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000560959.5","properties":[{"key":"ProteinId","value":"ENSP00000453724.1"},{"key":"GeneId","value":"ENSG00000140416.27"}]},{"database":"GeneID","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"7168","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:12010","properties":[{"key":"GeneName","value":"TPM1"}]},{"database":"OpenTargets","id":"ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000140416","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT01030000234542","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"128924at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"7168","properties":[{"key":"hits","value":"14 hits in 1165 CRISPR screens"}]},{"database":"ChiTaRS","id":"TPM1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"Bgee","id":"ENSG00000140416","properties":[{"key":"ExpressionPatterns","value":"Expressed in left ventricle myocardium and 216 other cell types or tissues"}]},{"database":"FunFam","id":"1.20.5.170:FF:000001","properties":[{"key":"EntryName","value":"Tropomyosin alpha-1 chain isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.170","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.340","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000533","properties":[{"key":"EntryName","value":"Tropomyosin"}]},{"database":"PANTHER","id":"PTHR19269","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00261","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00194","properties":[{"key":"EntryName","value":"TROPOMYOSIN"}]},{"database":"SUPFAM","id":"SSF57997","properties":[{"key":"EntryName","value":"Tropomyosin"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00326","properties":[{"key":"EntryName","value":"TROPOMYOSIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEGKILSSVFSLILMVEYQPGKTIFQFKGIHIDTLLCTCTFFLCVLWGFSLWLLNS","length":275,"molWeight":31753,"crc64":"449EE4040F0D2CC7","md5":"0B57CB92B4F98530CB0B84DBD189FED0"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Transmembrane":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI0001914EE3"}}]}