{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q15025","secondaryAccessions":["A4F1W8","A4F1W9","A4F1X2","A4F1X4","A4F1X5","A4F1X6","A4F1X7","A4F1X9","B7Z699","E7EPY1","E7ET96","O76008","Q05KP3","Q05KP4","Q6N077","Q96EL9","Q99833","Q9H1J3"],"uniProtkbId":"TNIP1_HUMAN","entryAudit":{"firstPublicDate":"2002-01-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1999-08-01","entryVersion":215,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"TNFAIP3-interacting protein 1"}},"alternativeNames":[{"fullName":{"value":"A20-binding inhibitor of NF-kappa-B activation 1"},"shortNames":[{"value":"ABIN-1"}]},{"fullName":{"value":"HIV-1 Nef-interacting protein"}},{"fullName":{"value":"Nef-associated factor 1"},"shortNames":[{"value":"Naf1"}]},{"fullName":{"value":"Nip40-1"}},{"fullName":{"value":"Virion-associated nuclear shuttling protein"},"shortNames":[{"value":"VAN"},{"value":"hVAN"}]}]},"genes":[{"geneName":{"value":"TNIP1"},"synonyms":[{"value":"KIAA0113"},{"value":"NAF1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12220502"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16684768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17016622"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17632516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20010814"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21885437"}],"value":"Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12220502"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16684768"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17632516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21885437"}],"value":"Interacts with TNFAIP3 and IKBKG (polyubiquitinated); facilitates TNFAIP3-mediated de-ubiquitination of NEMO/IKBKG. Interacts with polyubiquitin. Interacts with MAPK1, SELPLG and PIK3CD. Interacts with IRAK1 (polyubiquitinated). Interacts with MYD88; the interaction is indicative for participation in an activated TLR-signaling complex. Interacts with HIV-1 matrix protein. Interacts with TAX1BP1 (PubMed:21885437)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20010814"}],"value":"(Microbial infection) Interacts with Shigella flexneri ipah9.8; the interaction promotes polyubiquitination of 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isoforms seem to exist."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17016622"}],"value":"Ubiquitous. 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