{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P24821","secondaryAccessions":["C9IYT7","C9J575","C9J6D9","C9J848","Q14583","Q15567","Q5T7S3"],"uniProtkbId":"TENA_HUMAN","entryAudit":{"firstPublicDate":"1992-03-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-12-15","entryVersion":254,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Tenascin"},"shortNames":[{"value":"TN"}]},"alternativeNames":[{"fullName":{"value":"Cytotactin"}},{"fullName":{"value":"GMEM"}},{"fullName":{"value":"GP 150-225"}},{"fullName":{"value":"Glioma-associated-extracellular matrix antigen"}},{"fullName":{"value":"Hexabrachion"}},{"fullName":{"value":"JI"}},{"fullName":{"value":"Myotendinous antigen"}},{"fullName":{"value":"Neuronectin"}},{"fullName":{"value":"Tenascin-C"},"shortNames":[{"value":"TN-C"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"TNC"},"synonyms":[{"value":"HXB"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19884327"}],"value":"Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22654117"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8824254"}],"value":"Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (PubMed:8824254). Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1 (PubMed:22654117)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P24821","intActId":"EBI-9979894"},"interactantTwo":{"uniProtKBAccession":"P20908","geneName":"COL5A1","intActId":"EBI-2464511"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P24821","intActId":"EBI-9979894"},"interactantTwo":{"uniProtKBAccession":"O00206","geneName":"TLR4","intActId":"EBI-528701"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P24821","intActId":"EBI-9979894"},"interactantTwo":{"uniProtKBAccession":"P24821","geneName":"TNC","intActId":"EBI-9979894"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P24821-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"HT-5"}],"isoformIds":["P24821-2"],"sequenceIds":["VSP_001412","VSP_001413"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["P24821-3"],"sequenceIds":["VSP_001412"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"synonyms":[{"value":"HT-33"}],"isoformIds":["P24821-4"],"sequenceIds":["VSP_001413"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["P24821-5"],"sequenceIds":["VSP_001414"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"synonyms":[{"value":"P31"}],"isoformIds":["P24821-6"],"sequenceIds":["VSP_001415"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Isoforms are produced in a tissue- and time-specific manner during development."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36213313"}],"value":"Detected in fibroblasts (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Deafness, autosomal dominant, 56","diseaseAccession":"DI-04030","acronym":"DFNA56","description":"A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with postlingual onset.","diseaseCrossReference":{"database":"MIM","id":"615629"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23936043"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/42597/TNC","ftp":false}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1707164"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":2201,"modifier":"EXACT"}},"description":"Tenascin","featureId":"PRO_0000007741"},{"type":"Domain","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"EGF-like 1; incomplete","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"EGF-like 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"EGF-like 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"EGF-like 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like 5","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"EGF-like 6","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"EGF-like 7","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like 8","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"EGF-like 9","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"EGF-like 10","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":466,"modifier":"EXACT"},"end":{"value":497,"modifier":"EXACT"}},"description":"EGF-like 11","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":497,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"EGF-like 12","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":528,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"EGF-like 13","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":559,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"EGF-like 14","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":590,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"EGF-like 15","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":716,"modifier":"EXACT"},"end":{"value":804,"modifier":"EXACT"}},"description":"Fibronectin type-III 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III 3","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III 4","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III 5","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III 6","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"Fibronectin type-III 7","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1258,"modifier":"EXACT"},"end":{"value":1350,"modifier":"EXACT"}},"description":"Fibronectin type-III 8","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1351,"modifier":"EXACT"},"end":{"value":1439,"modifier":"EXACT"}},"description":"Fibronectin type-III 9","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1440,"modifier":"EXACT"},"end":{"value":1531,"modifier":"EXACT"}},"description":"Fibronectin type-III 10","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1533,"modifier":"EXACT"},"end":{"value":1621,"modifier":"EXACT"}},"description":"Fibronectin type-III 11","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1622,"modifier":"EXACT"},"end":{"value":1711,"modifier":"EXACT"}},"description":"Fibronectin type-III 12","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1712,"modifier":"EXACT"},"end":{"value":1801,"modifier":"EXACT"}},"description":"Fibronectin type-III 13","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1802,"modifier":"EXACT"},"end":{"value":1888,"modifier":"EXACT"}},"description":"Fibronectin type-III 14","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1889,"modifier":"EXACT"},"end":{"value":1977,"modifier":"EXACT"}},"description":"Fibronectin type-III 15","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00316"}]},{"type":"Domain","location":{"start":{"value":1975,"modifier":"EXACT"},"end":{"value":2190,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Coiled coil","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":905,"modifier":"EXACT"},"end":{"value":905,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Glycosylation","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"O-linked (Xyl...) (chondroitin sulfate) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36213313"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18780401"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":788,"modifier":"EXACT"},"end":{"value":788,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1018,"modifier":"EXACT"},"end":{"value":1018,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1034,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1079,"modifier":"EXACT"},"end":{"value":1079,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18780401"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1093,"modifier":"EXACT"},"end":{"value":1093,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18780401"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1119,"modifier":"EXACT"},"end":{"value":1119,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1184,"modifier":"EXACT"},"end":{"value":1184,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1210,"modifier":"EXACT"},"end":{"value":1210,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1261,"modifier":"EXACT"},"end":{"value":1261,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18780401"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1275,"modifier":"EXACT"},"end":{"value":1275,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1301,"modifier":"EXACT"},"end":{"value":1301,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18780401"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1366,"modifier":"EXACT"},"end":{"value":1366,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1392,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1445,"modifier":"EXACT"},"end":{"value":1445,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1455,"modifier":"EXACT"},"end":{"value":1455,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1485,"modifier":"EXACT"},"end":{"value":1485,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18780401"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1534,"modifier":"EXACT"},"end":{"value":1534,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1809,"modifier":"EXACT"},"end":{"value":1809,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16335952"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":2162,"modifier":"EXACT"},"end":{"value":2162,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18780401"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":325,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":330,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":434,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":443,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":487,"modifier":"EXACT"},"end":{"value":496,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":532,"modifier":"EXACT"},"end":{"value":542,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":536,"modifier":"EXACT"},"end":{"value":547,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":549,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":567,"modifier":"EXACT"},"end":{"value":578,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":580,"modifier":"EXACT"},"end":{"value":589,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":594,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":598,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":611,"modifier":"EXACT"},"end":{"value":620,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Alternative sequence","location":{"start":{"value":1072,"modifier":"EXACT"},"end":{"value":1708,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2466295"}],"featureId":"VSP_001415","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1072,"modifier":"EXACT"},"end":{"value":1617,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1707164"}],"featureId":"VSP_001414","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1072,"modifier":"EXACT"},"end":{"value":1435,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1707164"}],"featureId":"VSP_001412","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1527,"modifier":"EXACT"},"end":{"value":1617,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1707164"}],"featureId":"VSP_001413","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"in dbSNP:rs7020958","featureCrossReferences":[{"database":"dbSNP","id":"rs7020958"}],"featureId":"VAR_055778","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"in dbSNP:rs1757095","featureCrossReferences":[{"database":"dbSNP","id":"rs1757095"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1704365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1719530"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2466295"}],"featureId":"VAR_024266","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":605,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"in dbSNP:rs3827816","featureCrossReferences":[{"database":"dbSNP","id":"rs3827816"}],"featureId":"VAR_024267","alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":680,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"in dbSNP:rs1061494","featureCrossReferences":[{"database":"dbSNP","id":"rs1061494"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1707164"}],"featureId":"VAR_024268","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":850,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"in dbSNP:rs3748169","featureCrossReferences":[{"database":"dbSNP","id":"rs3748169"}],"featureId":"VAR_055779","alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1677,"modifier":"EXACT"},"end":{"value":1677,"modifier":"EXACT"}},"description":"in dbSNP:rs2104772","featureCrossReferences":[{"database":"dbSNP","id":"rs2104772"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1704365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1719530"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2466295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7531707"}],"featureId":"VAR_060738","alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":1773,"modifier":"EXACT"},"end":{"value":1773,"modifier":"EXACT"}},"description":"in DFNA56; dbSNP:rs137933052","featureCrossReferences":[{"database":"dbSNP","id":"rs137933052"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23936043"}],"featureId":"VAR_070984","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Natural variant","location":{"start":{"value":1781,"modifier":"EXACT"},"end":{"value":1781,"modifier":"EXACT"}},"description":"in dbSNP:rs2274750","featureCrossReferences":[{"database":"dbSNP","id":"rs2274750"}],"featureId":"VAR_020169","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":1796,"modifier":"EXACT"},"end":{"value":1796,"modifier":"EXACT"}},"description":"in DFNA56; dbSNP:rs431905513","featureCrossReferences":[{"database":"dbSNP","id":"rs431905513"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23936043"}],"featureId":"VAR_070985","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":2008,"modifier":"EXACT"},"end":{"value":2008,"modifier":"EXACT"}},"description":"in dbSNP:rs13321","featureCrossReferences":[{"database":"dbSNP","id":"rs13321"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1704365"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1707164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1719530"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2466295"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7531707"}],"featureId":"VAR_014665","alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"in Ref. 2; CAA39628","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"in Ref. 1; no nucleotide entry, 3; AAA88083 and 4; CAA55309","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":1066,"modifier":"EXACT"},"end":{"value":1066,"modifier":"EXACT"}},"description":"in Ref. 1; no nucleotide entry, 3; AAA88083 and 7; AAA52703","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":1600,"modifier":"EXACT"},"end":{"value":1608,"modifier":"EXACT"}},"description":"in Ref. 1; no nucleotide entry, 3; AAA88083 and 7; AAA52703","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"SGFTQGHQT","alternativeSequences":["LWLHPRASN"]}},{"type":"Sequence conflict","location":{"start":{"value":2054,"modifier":"EXACT"},"end":{"value":2054,"modifier":"EXACT"}},"description":"in Ref. 1; no nucleotide entry and 3; AAA88083","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["FLH"]}},{"type":"Sequence conflict","location":{"start":{"value":2055,"modifier":"EXACT"},"end":{"value":2055,"modifier":"EXACT"}},"description":"in Ref. 7; AAA52703","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":2140,"modifier":"EXACT"},"end":{"value":2143,"modifier":"EXACT"}},"description":"in Ref. 2; CAA39628","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"YKGA","alternativeSequences":["TRG"]}},{"type":"Helix","location":{"start":{"value":804,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RB8"}]},{"type":"Beta strand","location":{"start":{"value":807,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RB8"}]},{"type":"Beta strand","location":{"start":{"value":819,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RB8"}]},{"type":"Helix","location":{"start":{"value":827,"modifier":"EXACT"},"end":{"value":829,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RBL"}]},{"type":"Beta strand","location":{"start":{"value":831,"modifier":"EXACT"},"end":{"value":839,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RB8"}]},{"type":"Beta strand","location":{"start":{"value":842,"modifier":"EXACT"},"end":{"value":844,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RBL"}]},{"type":"Beta strand","location":{"start":{"value":847,"modifier":"EXACT"},"end":{"value":852,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RB8"}]},{"type":"Helix","location":{"start":{"value":853,"modifier":"EXACT"},"end":{"value":855,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6BRB"}]},{"type":"Beta strand","location":{"start":{"value":857,"modifier":"EXACT"},"end":{"value":860,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RB8"}]},{"type":"Beta strand","location":{"start":{"value":868,"modifier":"EXACT"},"end":{"value":877,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RB8"}]},{"type":"Helix","location":{"start":{"value":882,"modifier":"EXACT"},"end":{"value":884,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RB8"}]},{"type":"Beta strand","location":{"start":{"value":885,"modifier":"EXACT"},"end":{"value":890,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"2RB8"}]},{"type":"Helix","location":{"start":{"value":1015,"modifier":"EXACT"},"end":{"value":1017,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9NIH"}]},{"type":"Helix","location":{"start":{"value":1019,"modifier":"EXACT"},"end":{"value":1022,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9NIH"}]},{"type":"Beta strand","location":{"start":{"value":1977,"modifier":"EXACT"},"end":{"value":1980,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8FN8"}]},{"type":"Helix","location":{"start":{"value":1984,"modifier":"EXACT"},"end":{"value":1989,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":1996,"modifier":"EXACT"},"end":{"value":2001,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Helix","location":{"start":{"value":2002,"modifier":"EXACT"},"end":{"value":2004,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2008,"modifier":"EXACT"},"end":{"value":2015,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Helix","location":{"start":{"value":2018,"modifier":"EXACT"},"end":{"value":2020,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2023,"modifier":"EXACT"},"end":{"value":2032,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Helix","location":{"start":{"value":2040,"modifier":"EXACT"},"end":{"value":2045,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2052,"modifier":"EXACT"},"end":{"value":2055,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Helix","location":{"start":{"value":2058,"modifier":"EXACT"},"end":{"value":2065,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2070,"modifier":"EXACT"},"end":{"value":2078,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2081,"modifier":"EXACT"},"end":{"value":2092,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Helix","location":{"start":{"value":2095,"modifier":"EXACT"},"end":{"value":2097,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2101,"modifier":"EXACT"},"end":{"value":2110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Helix","location":{"start":{"value":2115,"modifier":"EXACT"},"end":{"value":2117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Helix","location":{"start":{"value":2120,"modifier":"EXACT"},"end":{"value":2122,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2130,"modifier":"EXACT"},"end":{"value":2134,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8FNB"}]},{"type":"Helix","location":{"start":{"value":2136,"modifier":"EXACT"},"end":{"value":2140,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2147,"modifier":"EXACT"},"end":{"value":2149,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2151,"modifier":"EXACT"},"end":{"value":2153,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Turn","location":{"start":{"value":2163,"modifier":"EXACT"},"end":{"value":2165,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2166,"modifier":"EXACT"},"end":{"value":2169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Helix","location":{"start":{"value":2170,"modifier":"EXACT"},"end":{"value":2173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Beta strand","location":{"start":{"value":2180,"modifier":"EXACT"},"end":{"value":2188,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]},{"type":"Helix","location":{"start":{"value":2189,"modifier":"EXACT"},"end":{"value":2193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5R61"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0209","category":"Disease","name":"Deafness"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-1010","category":"Disease","name":"Non-syndromic deafness"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"1704365","citationType":"journal article","authors":["Nies D.E.","Hemesath T.J.","Kim J.H.","Gulcher J.R.","Stefansson K."],"citationCrossReferences":[{"database":"PubMed","id":"1704365"},{"database":"DOI","id":"10.1016/s0021-9258(18)49920-6"}],"title":"The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats.","publicationDate":"1991","journal":"J. Biol. Chem.","firstPage":"2818","lastPage":"2823","volume":"266"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANTS ARG-539; LEU-1677 AND GLN-2008"]},{"referenceNumber":2,"citation":{"id":"1707164","citationType":"journal article","authors":["Siri A.","Carnemolla B.","Saginati M.","Leprini A.","Casari G.","Baralle F.","Zardi L."],"citationCrossReferences":[{"database":"PubMed","id":"1707164"},{"database":"DOI","id":"10.1093/nar/19.3.525"}],"title":"Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies.","publicationDate":"1991","journal":"Nucleic Acids Res.","firstPage":"525","lastPage":"531","volume":"19"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4 AND 5)","PROTEIN SEQUENCE OF 23-32","VARIANTS ARG-680 AND GLN-2008"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"},{"value":"Melanoma","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"1719530","citationType":"journal article","authors":["Gulcher J.R.","Nies D.E.","Alexakos M.J.","Ravikant N.A.","Sturgill M.E.","Marton L.S.","Stefansson K."],"citationCrossReferences":[{"database":"PubMed","id":"1719530"},{"database":"DOI","id":"10.1073/pnas.88.21.9438"}],"title":"Structure of the human hexabrachion (tenascin) gene.","publicationDate":"1991","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"9438","lastPage":"9442","volume":"88"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANTS ARG-539; LEU-1677 AND GLN-2008"]},{"referenceNumber":4,"citation":{"id":"7531707","citationType":"journal article","authors":["Gherzi R.","Carnemolla B.","Siri A.","Ponassi M.","Balza E.","Zardi L."],"citationCrossReferences":[{"database":"PubMed","id":"7531707"},{"database":"DOI","id":"10.1074/jbc.270.7.3429"}],"title":"Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences.","publicationDate":"1995","journal":"J. Biol. Chem.","firstPage":"3429","lastPage":"3434","volume":"270"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","VARIANTS LEU-1677 AND GLN-2008"]},{"referenceNumber":5,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.S.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.R.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.I.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.M.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"7524681","citationType":"journal article","authors":["Glumoff V.","Savontaus M.","Vehanen J.","Vuorio E."],"citationCrossReferences":[{"database":"PubMed","id":"7524681"},{"database":"DOI","id":"10.1016/0167-4781(94)90220-8"}],"title":"Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes.","publicationDate":"1994","journal":"Biochim. Biophys. Acta","firstPage":"613","lastPage":"622","volume":"1219"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 46-125 (ISOFORMS 1/2/3/4/5/6)"],"referenceComments":[{"value":"Fetal cartilage","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"2466295","citationType":"journal article","authors":["Gulcher J.R.","Nies D.E.","Marton L.S.","Stefansson K."],"citationCrossReferences":[{"database":"PubMed","id":"2466295"},{"database":"DOI","id":"10.1073/pnas.86.5.1588"}],"title":"An alternatively spliced region of the human hexabrachion contains a repeat of potential N-glycosylation sites.","publicationDate":"1989","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1588","lastPage":"1592","volume":"86"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 431-2055 (ISOFORMS 1 AND 6)","VARIANTS ARG-539; LEU-1677 AND GLN-2008"],"referenceComments":[{"value":"Glioblastoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"8824254","citationType":"journal article","authors":["Burg M.A.","Tillet E.","Timpl R.","Stallcup W.B."],"citationCrossReferences":[{"database":"PubMed","id":"8824254"},{"database":"DOI","id":"10.1074/jbc.271.42.26110"}],"title":"Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules.","publicationDate":"1996","journal":"J. Biol. Chem.","firstPage":"26110","lastPage":"26116","volume":"271"},"referencePositions":["INTERACTION WITH CSPG4"]},{"referenceNumber":9,"citation":{"id":"16335952","citationType":"journal article","authors":["Liu T.","Qian W.-J.","Gritsenko M.A.","Camp D.G. II","Monroe M.E.","Moore R.J.","Smith R.D."],"citationCrossReferences":[{"database":"PubMed","id":"16335952"},{"database":"DOI","id":"10.1021/pr0502065"}],"title":"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.","publicationDate":"2005","journal":"J. Proteome Res.","firstPage":"2070","lastPage":"2080","volume":"4"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1809"],"referenceComments":[{"value":"Plasma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"18780401","citationType":"journal article","authors":["Picariello G.","Ferranti P.","Mamone G.","Roepstorff P.","Addeo F."],"citationCrossReferences":[{"database":"PubMed","id":"18780401"},{"database":"DOI","id":"10.1002/pmic.200701057"}],"title":"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.","publicationDate":"2008","journal":"Proteomics","firstPage":"3833","lastPage":"3847","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184; ASN-1079; ASN-1093; ASN-1261; ASN-1301; ASN-1485 AND ASN-2162"],"referenceComments":[{"value":"Milk","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1018; ASN-1034; ASN-1184; ASN-1275; ASN-1301; ASN-1366 AND ASN-1485"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"19884327","citationType":"journal article","authors":["Martina E.","Degen M.","Rueegg C.","Merlo A.","Lino M.M.","Chiquet-Ehrismann R.","Brellier F."],"citationCrossReferences":[{"database":"PubMed","id":"19884327"},{"database":"DOI","id":"10.1096/fj.09-140491"}],"title":"Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro.","publicationDate":"2010","journal":"FASEB J.","firstPage":"778","lastPage":"787","volume":"24"},"referencePositions":["FUNCTION"]},{"referenceNumber":13,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":14,"citation":{"id":"22654117","citationType":"journal article","authors":["Sato-Nishiuchi R.","Nakano I.","Ozawa A.","Sato Y.","Takeichi M.","Kiyozumi D.","Yamazaki K.","Yasunaga T.","Futaki S.","Sekiguchi K."],"citationCrossReferences":[{"database":"PubMed","id":"22654117"},{"database":"DOI","id":"10.1074/jbc.m112.355016"}],"title":"Polydom/SVEP1 is a ligand for integrin alpha9beta1.","publicationDate":"2012","journal":"J. Biol. Chem.","firstPage":"25615","lastPage":"25630","volume":"287"},"referencePositions":["INTERACTION WITH ITGA9:ITGB1"]},{"referenceNumber":15,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-70; SER-72 AND THR-905","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"26091039","citationType":"journal article","authors":["Tagliabracci V.S.","Wiley S.E.","Guo X.","Kinch L.N.","Durrant E.","Wen J.","Xiao J.","Cui J.","Nguyen K.B.","Engel J.L.","Coon J.J.","Grishin N.","Pinna L.A.","Pagliarini D.J.","Dixon J.E."],"citationCrossReferences":[{"database":"PubMed","id":"26091039"},{"database":"DOI","id":"10.1016/j.cell.2015.05.028"}],"title":"A single kinase generates the majority of the secreted phosphoproteome.","publicationDate":"2015","journal":"Cell","firstPage":"1619","lastPage":"1632","volume":"161"},"referencePositions":["PHOSPHORYLATION AT SER-72"]},{"referenceNumber":17,"citation":{"id":"36213313","citationType":"journal article","authors":["Ramarajan M.G.","Saraswat M.","Budhraja R.","Garapati K.","Raymond K.","Pandey A."],"citationCrossReferences":[{"database":"PubMed","id":"36213313"},{"database":"DOI","id":"10.1007/s42485-022-00092-3"}],"title":"Mass spectrometric analysis of chondroitin sulfate-linked peptides.","publicationDate":"2022","journal":"J. Proteins Proteom.","firstPage":"187","lastPage":"203","volume":"13"},"referencePositions":["TISSUE SPECIFICITY","GLYCOSYLATION AT SER-72"]},{"referenceNumber":18,"citation":{"id":"1279805","citationType":"journal article","authors":["Leahy D.J.","Hendrickson W.A.","Aukhil I.","Erickson H.P."],"citationCrossReferences":[{"database":"PubMed","id":"1279805"},{"database":"DOI","id":"10.1126/science.1279805"}],"title":"Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.","publicationDate":"1992","journal":"Science","firstPage":"987","lastPage":"991","volume":"258"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF FIBRONECTIN TYPE-III 3"]},{"referenceNumber":19,"citation":{"id":"23936043","citationType":"journal article","authors":["Zhao Y.","Zhao F.","Zong L.","Zhang P.","Guan L.","Zhang J.","Wang D.","Wang J.","Chai W.","Lan L.","Li Q.","Han B.","Yang L.","Jin X.","Yang W.","Hu X.","Wang X.","Li N.","Li Y.","Petit C.","Wang J.","Wang H.Y.","Wang Q."],"citationCrossReferences":[{"database":"PubMed","id":"23936043"},{"database":"DOI","id":"10.1371/journal.pone.0069549"}],"title":"Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss.","publicationDate":"2013","journal":"PLoS ONE","firstPage":"E69549","lastPage":"E69549","volume":"8"},"referencePositions":["VARIANTS DFNA56 MET-1773 AND SER-1796"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M55618","properties":[{"key":"ProteinId","value":"AAA88083.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X56160","properties":[{"key":"ProteinId","value":"CAA39628.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X78565","properties":[{"key":"ProteinId","value":"CAA55309.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X80280","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M24630","properties":[{"key":"ProteinId","value":"AAA52703.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS6811.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P24821-1"},{"database":"PIR","id":"I38337","properties":[{"key":"EntryName","value":"A32160"}]},{"database":"RefSeq","id":"NP_001426004.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439075.1"}],"isoformId":"P24821-1"},{"database":"RefSeq","id":"NP_001426005.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439076.1"}],"isoformId":"P24821-1"},{"database":"RefSeq","id":"NP_001426006.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439077.1"}],"isoformId":"P24821-4"},{"database":"RefSeq","id":"NP_001426007.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439078.1"}],"isoformId":"P24821-4"},{"database":"RefSeq","id":"NP_001426008.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439079.1"}],"isoformId":"P24821-4"},{"database":"RefSeq","id":"NP_001426019.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439090.1"}],"isoformId":"P24821-3"},{"database":"RefSeq","id":"NP_001426023.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439094.1"}],"isoformId":"P24821-2"},{"database":"RefSeq","id":"NP_001426025.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439096.1"}],"isoformId":"P24821-5"},{"database":"RefSeq","id":"NP_001426028.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439099.1"}],"isoformId":"P24821-6"},{"database":"RefSeq","id":"NP_001426029.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439100.1"}],"isoformId":"P24821-6"},{"database":"RefSeq","id":"NP_001426030.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439101.1"}],"isoformId":"P24821-6"},{"database":"RefSeq","id":"NP_002151.2","properties":[{"key":"NucleotideSequenceId","value":"NM_002160.4"}],"isoformId":"P24821-1"},{"database":"PDB","id":"1TEN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A=802-891"}]},{"database":"PDB","id":"2RB8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A=802-893"}]},{"database":"PDB","id":"2RBL","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.10 A"},{"key":"Chains","value":"A/B/M=802-893"}]},{"database":"PDB","id":"5R5T","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R5U","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R5V","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R5W","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R5X","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.56 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R5Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.57 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R5Z","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R60","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.79 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R61","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.38 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R62","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"5R63","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.59 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"6BRB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.82 A"},{"key":"Chains","value":"D=809-893"}]},{"database":"PDB","id":"6QNV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A=1979-2196"}]},{"database":"PDB","id":"8FN8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.89 A"},{"key":"Chains","value":"A=1975-2201"}]},{"database":"PDB","id":"8FNB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=1975-2201"}]},{"database":"PDB","id":"9NIG","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"G/L/P=1013-1024"}]},{"database":"PDB","id":"9NIH","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"C=1013-1024"}]},{"database":"PDB","id":"9R5Y","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/D=1976-2193"}]},{"database":"PDBsum","id":"1TEN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2RB8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"2RBL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R5T","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R5U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R5V","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R5W","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R5X","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R5Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R5Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R60","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R61","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R62","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5R63","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6BRB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6QNV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FN8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8FNB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9NIG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9NIH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9R5Y","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"MDposit","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109602","properties":[{"key":"Interactions","value":"30"}]},{"database":"ComplexPortal","id":"CPX-466","properties":[{"key":"EntryName","value":"Tenascin-C complex"}]},{"database":"CORUM","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P24821","properties":[{"key":"Number of interactors","value":"615"}]},{"database":"IntAct","id":"P24821","properties":[{"key":"Interactions","value":"17"}]},{"database":"MINT","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-TNC","properties":[{"key":"Evidences","value":"13 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000265131","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3712856","properties":[{"key":"Description","value":"-"}]},{"database":"UniLectin","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P24821","properties":[{"key":"glycosylation","value":"65 N-Linked glycans (14 sites)"}]},{"database":"GlyCosmos","id":"P24821","properties":[{"key":"glycosylation","value":"31 sites, 67 glycans"}]},{"database":"GlyGen","id":"P24821","properties":[{"key":"glycosylation","value":"32 sites, 200 N-linked glycans (15 sites), 2 O-linked glycans (8 sites)"}]},{"database":"iPTMnet","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TNC","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"281185495","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"non-CPTAC-2700","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000265131","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54225","properties":[{"key":"Description","value":"-"}],"isoformId":"P24821-1"},{"database":"ProteomicsDB","id":"54226","properties":[{"key":"Description","value":"-"}],"isoformId":"P24821-2"},{"database":"ProteomicsDB","id":"54227","properties":[{"key":"Description","value":"-"}],"isoformId":"P24821-3"},{"database":"ProteomicsDB","id":"54228","properties":[{"key":"Description","value":"-"}],"isoformId":"P24821-4"},{"database":"ProteomicsDB","id":"54229","properties":[{"key":"Description","value":"-"}],"isoformId":"P24821-5"},{"database":"ProteomicsDB","id":"54230","properties":[{"key":"Description","value":"-"}],"isoformId":"P24821-6"},{"database":"Pumba","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"P24821","properties":[{"key":"antibodies","value":"55 sequenced antibodies"}]},{"database":"Antibodypedia","id":"1348","properties":[{"key":"antibodies","value":"1069 antibodies from 46 providers"}]},{"database":"DNASU","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000350763.9","properties":[{"key":"ProteinId","value":"ENSP00000265131.4"},{"key":"GeneId","value":"ENSG00000041982.18"}],"isoformId":"P24821-1"},{"database":"Ensembl","id":"ENST00000537320.6","properties":[{"key":"ProteinId","value":"ENSP00000443478.1"},{"key":"GeneId","value":"ENSG00000041982.18"}],"isoformId":"P24821-6"},{"database":"Ensembl","id":"ENST00000901446.1","properties":[{"key":"ProteinId","value":"ENSP00000571505.1"},{"key":"GeneId","value":"ENSG00000041982.18"}],"isoformId":"P24821-6"},{"database":"Ensembl","id":"ENST00000901448.1","properties":[{"key":"ProteinId","value":"ENSP00000571507.1"},{"key":"GeneId","value":"ENSG00000041982.18"}],"isoformId":"P24821-6"},{"database":"Ensembl","id":"ENST00000901449.1","properties":[{"key":"ProteinId","value":"ENSP00000571508.1"},{"key":"GeneId","value":"ENSG00000041982.18"}],"isoformId":"P24821-6"},{"database":"Ensembl","id":"ENST00000932049.1","properties":[{"key":"ProteinId","value":"ENSP00000602108.1"},{"key":"GeneId","value":"ENSG00000041982.18"}],"isoformId":"P24821-3"},{"database":"Ensembl","id":"ENST00000968433.1","properties":[{"key":"ProteinId","value":"ENSP00000638492.1"},{"key":"GeneId","value":"ENSG00000041982.18"}],"isoformId":"P24821-6"},{"database":"GeneID","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3371","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000350763.9","properties":[{"key":"ProteinId","value":"ENSP00000265131.4"},{"key":"RefSeqNucleotideId","value":"NM_002160.4"},{"key":"RefSeqProteinId","value":"NP_002151.2"}]},{"database":"UCSC","id":"uc004bjj.6","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P24821-1"},{"database":"AGR","id":"HGNC:5318","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"3371","properties":[{"key":"Number of evidences","value":"2 evidence items across 1 molecular profile"}]},{"database":"ClinPGx","id":"PA35103","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TNC","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"HPA","id":"ENSG00000041982","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (blood vessel, smooth muscle)"}]},{"database":"MalaCards","id":"TNC","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"187380","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"615629","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"90635","properties":[{"key":"Disease","value":"Autosomal dominant non-syndromic genetic deafness"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1225","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG2579","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001162_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HHNGRCE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P24821","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-216083","properties":[{"key":"PathwayName","value":"Integrin cell surface interactions"}]},{"database":"Reactome","id":"R-HSA-3000170","properties":[{"key":"PathwayName","value":"Syndecan interactions"}]},{"database":"Reactome","id":"R-HSA-3000178","properties":[{"key":"PathwayName","value":"ECM proteoglycans"}]},{"database":"Reactome","id":"R-HSA-381426","properties":[{"key":"PathwayName","value":"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"}]},{"database":"Reactome","id":"R-HSA-8957275","properties":[{"key":"PathwayName","value":"Post-translational protein phosphorylation"}]},{"database":"SignaLink","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000041982","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3371","properties":[{"key":"hits","value":"10 hits in 1156 CRISPR screens"}]},{"database":"CD-CODE","id":"FB4E32DD","properties":[{"key":"EntryName","value":"Presynaptic clusters and postsynaptic densities"}]},{"database":"ChiTaRS","id":"TNC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P24821","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Tenascin_C","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P24821","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P24821","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"P24821","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000041982","properties":[{"key":"ExpressionPatterns","value":"Expressed in saphenous vein and 187 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P24821","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005604","properties":[{"key":"GoTerm","value":"C:basement membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005788","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23658023"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"16502470"}]},{"database":"GO","id":"GO:0005925","properties":[{"key":"GoTerm","value":"C:focal adhesion"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"21423176"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"16210410"}]},{"database":"GO","id":"GO:0098966","properties":[{"key":"GoTerm","value":"C:perisynaptic extracellular matrix"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0090733","properties":[{"key":"GoTerm","value":"C:tenascin complex"},{"key":"GoEvidenceType","value":"TAS:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"10842355"}]},{"database":"GO","id":"GO:0005201","properties":[{"key":"GoTerm","value":"F:extracellular matrix structural constituent"},{"key":"GoEvidenceType","value":"ISS:BHF-UCL"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17971437"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"29150600"}]},{"database":"GO","id":"GO:0005178","properties":[{"key":"GoTerm","value":"F:integrin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22654117"}]},{"database":"GO","id":"GO:0045545","properties":[{"key":"GoTerm","value":"F:syndecan binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8769660"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"1704365"}]},{"database":"GO","id":"GO:0002009","properties":[{"key":"GoTerm","value":"P:morphogenesis of an epithelium"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001649","properties":[{"key":"GoTerm","value":"P:osteoblast differentiation"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"16210410"}]},{"database":"GO","id":"GO:0030155","properties":[{"key":"GoTerm","value":"P:regulation of cell adhesion"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11731446"}]},{"database":"GO","id":"GO:0001558","properties":[{"key":"GoTerm","value":"P:regulation of cell growth"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11731446"}]},{"database":"GO","id":"GO:0030334","properties":[{"key":"GoTerm","value":"P:regulation of cell migration"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12845616"}]},{"database":"GO","id":"GO:0050727","properties":[{"key":"GoTerm","value":"P:regulation of inflammatory response"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16891397"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"4"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"14"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000610","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"15"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"15"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"15"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"12"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"15"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"15"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"15"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":2201,"molWeight":240853,"crc64":"B2BEF378AA6F1D85","md5":"E8427BF5A0779ECA20887E59E5E98982"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":6,"TISSUE SPECIFICITY":1,"DISEASE":1,"SIMILARITY":1,"WEB RESOURCE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":31,"Coiled coil":1,"Modified residue":4,"Glycosylation":24,"Disulfide bond":42,"Alternative sequence":4,"Natural variant":10,"Sequence conflict":7,"Helix":17,"Beta strand":21,"Turn":1},"uniParcId":"UPI000013D5BD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S623","uniProtkbId":"A0ACI8S623_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571510.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571510.1"}],"value":"TNC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00063616"}],"value":"Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1655,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051363868"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":896,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":897,"modifier":"EXACT"},"end":{"value":986,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":987,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1166,"modifier":"EXACT"},"end":{"value":1255,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1256,"modifier":"EXACT"},"end":{"value":1342,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1343,"modifier":"EXACT"},"end":{"value":1431,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1429,"modifier":"EXACT"},"end":{"value":1644,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1590,"modifier":"EXACT"},"end":{"value":1603,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S623"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S623"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571510.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571510.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571510.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571510.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001426027.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439098.1"}]},{"database":"Ensembl","id":"ENST00000901451.1","properties":[{"key":"ProteinId","value":"ENSP00000571510.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"GeneID","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"8"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"9"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"9"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"9"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"6"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"8"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1655,"molWeight":181205,"crc64":"3AD96DA10DAE05E2","md5":"1355B9F1C1E33835211359227B93B410"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":11,"Disulfide bond":5},"uniParcId":"UPI001FB19A66"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SGH9","uniProtkbId":"A0ACI8SGH9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571511.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571511.1"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1837,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051254048"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1259,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1348,"modifier":"EXACT"},"end":{"value":1437,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1438,"modifier":"EXACT"},"end":{"value":1524,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1525,"modifier":"EXACT"},"end":{"value":1613,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1611,"modifier":"EXACT"},"end":{"value":1826,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1772,"modifier":"EXACT"},"end":{"value":1785,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SGH9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SGH9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571511.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571511.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571511.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571511.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000901452.1","properties":[{"key":"ProteinId","value":"ENSP00000571511.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"11"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"11"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"8"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"9"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1837,"molWeight":200840,"crc64":"A5C3AEE1C747CA1B","md5":"C67A55866EBA2D9F999113CE0C8F999B"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":12,"Disulfide bond":5},"uniParcId":"UPI004031C5D8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VM26","uniProtkbId":"A0ACI8VM26_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638493.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638493.1"}],"value":"TNC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00063616"}],"value":"Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1837,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051554580"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1168,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1258,"modifier":"EXACT"},"end":{"value":1347,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1348,"modifier":"EXACT"},"end":{"value":1437,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1438,"modifier":"EXACT"},"end":{"value":1524,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1525,"modifier":"EXACT"},"end":{"value":1613,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1611,"modifier":"EXACT"},"end":{"value":1826,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1772,"modifier":"EXACT"},"end":{"value":1785,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VM26"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VM26"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638493.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638493.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638493.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638493.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000968434.1","properties":[{"key":"ProteinId","value":"ENSP00000638493.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"10"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"11"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"11"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"8"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"9"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1837,"molWeight":201069,"crc64":"2BE0E97901643A37","md5":"20D7E6E0BE8C98D3CA161475B329C042"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":12,"Disulfide bond":5},"uniParcId":"UPI0040322651"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8R5D1","uniProtkbId":"A0ACI8R5D1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571506.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571506.1"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1837,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051506140"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1258,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1259,"modifier":"EXACT"},"end":{"value":1347,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1348,"modifier":"EXACT"},"end":{"value":1437,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1438,"modifier":"EXACT"},"end":{"value":1524,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1525,"modifier":"EXACT"},"end":{"value":1613,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1611,"modifier":"EXACT"},"end":{"value":1826,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1772,"modifier":"EXACT"},"end":{"value":1785,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8R5D1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8R5D1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571506.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571506.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571506.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571506.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000901447.1","properties":[{"key":"ProteinId","value":"ENSP00000571506.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"11"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"11"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"8"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"10"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1837,"molWeight":201158,"crc64":"F6835F49561B5147","md5":"CBF0E4D1C24A33F07204A8545730EB47"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":13,"Disulfide bond":5},"uniParcId":"UPI004031687B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A994J7C1","uniProtkbId":"A0A994J7C1_HUMAN","entryAudit":{"firstPublicDate":"2023-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-05-03","entryVersion":17,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516085.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516085.1"}],"value":"TNC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00063616"}],"value":"Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":549,"modifier":"EXACT"},"end":{"value":638,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":639,"modifier":"EXACT"},"end":{"value":734,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":735,"modifier":"EXACT"},"end":{"value":819,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":820,"modifier":"EXACT"},"end":{"value":909,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":911,"modifier":"EXACT"},"end":{"value":1000,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1002,"modifier":"EXACT"},"end":{"value":1094,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1184,"modifier":"EXACT"},"end":{"value":1273,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1275,"modifier":"EXACT"},"end":{"value":1364,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1365,"modifier":"EXACT"},"end":{"value":1454,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1455,"modifier":"EXACT"},"end":{"value":1541,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1542,"modifier":"EXACT"},"end":{"value":1630,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1628,"modifier":"EXACT"},"end":{"value":1843,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1789,"modifier":"EXACT"},"end":{"value":1802,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516085.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A994J7C1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A994J7C1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516085.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516085.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516085.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516085.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000705192.1","properties":[{"key":"ProteinId","value":"ENSP00000516085.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"ExpressionAtlas","id":"A0A994J7C1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"13"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"11"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"14"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"12"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"12"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"14"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"11"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"4"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"12"}]}],"sequence":{"value":"XEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1854,"molWeight":203672,"crc64":"3781874D27180F68","md5":"73F8F5A3827DAC4659C81AC29E9AA052"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":15,"Disulfide bond":5,"Non-terminal residue":1},"uniParcId":"UPI0021EB9636"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QUE8","uniProtkbId":"A0ACI8QUE8_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571502.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571502.1"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1655,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051203163"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1166,"modifier":"EXACT"},"end":{"value":1255,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1256,"modifier":"EXACT"},"end":{"value":1342,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1343,"modifier":"EXACT"},"end":{"value":1431,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1429,"modifier":"EXACT"},"end":{"value":1644,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1590,"modifier":"EXACT"},"end":{"value":1603,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QUE8"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QUE8"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571502.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571502.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571502.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571502.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001426026.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439097.1"}]},{"database":"Ensembl","id":"ENST00000901443.1","properties":[{"key":"ProteinId","value":"ENSP00000571502.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"GeneID","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"9"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"9"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"9"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"9"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"6"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"8"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1655,"molWeight":181227,"crc64":"DD9D1424BE5C2196","md5":"08C7E951C92314027448E33D5E6BB459"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":11,"Disulfide bond":5},"uniParcId":"UPI0003EAF111"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8VLR0","uniProtkbId":"A0ACI8VLR0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638494.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638494.1"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1279,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051224361"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":430,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":610,"modifier":"EXACT"},"end":{"value":705,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":879,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":880,"modifier":"EXACT"},"end":{"value":966,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":967,"modifier":"EXACT"},"end":{"value":1055,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1053,"modifier":"EXACT"},"end":{"value":1268,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1214,"modifier":"EXACT"},"end":{"value":1227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8VLR0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8VLR0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638494.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638494.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638494.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000638494.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000968435.1","properties":[{"key":"ProteinId","value":"ENSP00000638494.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"8"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"8"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"5"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"7"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"5"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"8"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"6"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1279,"molWeight":140939,"crc64":"56D03F7274599875","md5":"BD8D2DC4B4AD58B9FBE42B48C7E92BFA"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":8,"Disulfide bond":3},"uniParcId":"UPI00403185F8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"E9PC84","uniProtkbId":"E9PC84_HUMAN","entryAudit":{"firstPublicDate":"2011-04-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":103,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411406.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411406.2"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1928,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003244016"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1258,"modifier":"EXACT"},"end":{"value":1350,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1439,"modifier":"EXACT"},"end":{"value":1528,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1529,"modifier":"EXACT"},"end":{"value":1615,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1616,"modifier":"EXACT"},"end":{"value":1704,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1702,"modifier":"EXACT"},"end":{"value":1917,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1863,"modifier":"EXACT"},"end":{"value":1876,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"E9PC84"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"E9PC84"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411406.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411406.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411406.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000411406.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"E9PC84","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"E9PC84","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"E9PC84","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"19393","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1348","properties":[{"key":"antibodies","value":"1069 antibodies from 46 providers"}]},{"database":"Ensembl","id":"ENST00000423613.6","properties":[{"key":"ProteinId","value":"ENSP00000411406.2"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"Ensembl","id":"ENST00000968432.1","properties":[{"key":"ProteinId","value":"ENSP00000638491.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"UCSC","id":"uc010mvf.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TNC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"Bgee","id":"ENSG00000041982","properties":[{"key":"ExpressionPatterns","value":"Expressed in saphenous vein and 187 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"E9PC84","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"12"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"12"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"12"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"12"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"9"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"10"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1928,"molWeight":210854,"crc64":"141AD591043D1CB4","md5":"41A11B753A59A5672A9D9D36E7BF1358"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":13,"Disulfide bond":5},"uniParcId":"UPI0001AE6E72"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q4LE33","uniProtkbId":"Q4LE33_HUMAN","entryAudit":{"firstPublicDate":"2005-08-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-08-02","entryVersion":139,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE06120.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE06120.1"}],"value":"TNC variant protein"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00063616"}],"value":"Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":436,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":657,"modifier":"EXACT"},"end":{"value":747,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":837,"modifier":"EXACT"},"end":{"value":926,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":927,"modifier":"EXACT"},"end":{"value":1022,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1023,"modifier":"EXACT"},"end":{"value":1107,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1108,"modifier":"EXACT"},"end":{"value":1197,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1199,"modifier":"EXACT"},"end":{"value":1288,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1290,"modifier":"EXACT"},"end":{"value":1382,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1472,"modifier":"EXACT"},"end":{"value":1563,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1654,"modifier":"EXACT"},"end":{"value":1743,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1744,"modifier":"EXACT"},"end":{"value":1833,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1834,"modifier":"EXACT"},"end":{"value":1920,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1921,"modifier":"EXACT"},"end":{"value":2009,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":2007,"modifier":"EXACT"},"end":{"value":2222,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Region","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Disulfide bond","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":333,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":2168,"modifier":"EXACT"},"end":{"value":2181,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE06120.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-1DVUKGU9SI55Q","citationType":"submission","authors":["Nakajima D.","Saito K.","Yamakawa H.","Kikuno R.F.","Nakayama M.","Ohara R.","Okazaki N.","Koga H.","Nagase T.","Ohara O."],"title":"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method.","publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE06120.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAE06120.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB210038","properties":[{"key":"ProteinId","value":"BAE06120.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PeptideAtlas","id":"Q4LE33","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA35103","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3371","properties":[{"key":"hits","value":"10 hits in 1156 CRISPR screens"}]},{"database":"ChiTaRS","id":"TNC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"4"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"14"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000610","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"15"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"15"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"15"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"12"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"12"}]}],"sequence":{"value":"SLLCASKSPILLKVRYPRALEPQQHPAKPTSTMGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGRGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIRELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPAHVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":2233,"molWeight":244404,"crc64":"3AB15331FB1E92E7","md5":"8210B119E967A70A7238305C8F273849"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Domain":15,"Region":1,"Disulfide bond":5,"Non-terminal residue":1},"uniParcId":"UPI000054C934"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SBK6","uniProtkbId":"A0ACI8SBK6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571503.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571503.1"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1746,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051467938"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1257,"modifier":"EXACT"},"end":{"value":1346,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1347,"modifier":"EXACT"},"end":{"value":1433,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1434,"modifier":"EXACT"},"end":{"value":1522,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1520,"modifier":"EXACT"},"end":{"value":1735,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1681,"modifier":"EXACT"},"end":{"value":1694,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SBK6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SBK6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571503.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571503.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571503.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571503.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001426022.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439093.1"}]},{"database":"RefSeq","id":"NP_001426024.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439095.1"}]},{"database":"Ensembl","id":"ENST00000901444.1","properties":[{"key":"ProteinId","value":"ENSP00000571503.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"GeneID","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"10"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"10"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"10"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"10"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"7"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"9"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1746,"molWeight":190990,"crc64":"350C719C43996E4E","md5":"B1CD41CBE5725E5F9D9617F40D32859D"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":12,"Disulfide bond":5},"uniParcId":"UPI0005D0214F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RSE7","uniProtkbId":"A0ACI8RSE7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571509.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571509.1"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":2019,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051259874"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1258,"modifier":"EXACT"},"end":{"value":1349,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1440,"modifier":"EXACT"},"end":{"value":1529,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1530,"modifier":"EXACT"},"end":{"value":1619,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1620,"modifier":"EXACT"},"end":{"value":1706,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1707,"modifier":"EXACT"},"end":{"value":1795,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1793,"modifier":"EXACT"},"end":{"value":2008,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1954,"modifier":"EXACT"},"end":{"value":1967,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RSE7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RSE7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571509.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571509.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571509.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571509.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000901450.1","properties":[{"key":"ProteinId","value":"ENSP00000571509.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"13"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000610","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"13"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"13"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"13"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"10"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":2019,"molWeight":221158,"crc64":"CB4C3FEE56753F44","md5":"E1E2962650E81B6FA5853ECA078A0B63"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":14,"Disulfide bond":5},"uniParcId":"UPI004032195F"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S5B9","uniProtkbId":"A0ACI8S5B9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571504.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571504.1"}],"value":"TNC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00063616"}],"value":"Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":2019,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051275882"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1258,"modifier":"EXACT"},"end":{"value":1350,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1440,"modifier":"EXACT"},"end":{"value":1529,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1530,"modifier":"EXACT"},"end":{"value":1619,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1620,"modifier":"EXACT"},"end":{"value":1706,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1707,"modifier":"EXACT"},"end":{"value":1795,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1793,"modifier":"EXACT"},"end":{"value":2008,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1954,"modifier":"EXACT"},"end":{"value":1967,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S5B9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S5B9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571504.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571504.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571504.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000571504.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001426013.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439084.1"}]},{"database":"RefSeq","id":"NP_001426014.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439085.1"}]},{"database":"RefSeq","id":"NP_001426015.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439086.1"}]},{"database":"Ensembl","id":"ENST00000901445.1","properties":[{"key":"ProteinId","value":"ENSP00000571504.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"GeneID","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"12"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"13"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"13"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"13"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"10"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":2019,"molWeight":220699,"crc64":"94472C4DF3EA1BB3","md5":"3C5519A791D2C41E35BDADE1DE1CAFE0"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":14,"Disulfide bond":5},"uniParcId":"UPI0005D029AB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8TP14","uniProtkbId":"A0ACI8TP14_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000602107.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000602107.1"}],"value":"TNC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00063616"}],"value":"Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1928,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051354304"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1257,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1258,"modifier":"EXACT"},"end":{"value":1347,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1349,"modifier":"EXACT"},"end":{"value":1438,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1439,"modifier":"EXACT"},"end":{"value":1528,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1529,"modifier":"EXACT"},"end":{"value":1615,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1616,"modifier":"EXACT"},"end":{"value":1704,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1702,"modifier":"EXACT"},"end":{"value":1917,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1863,"modifier":"EXACT"},"end":{"value":1876,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8TP14"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8TP14"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000602107.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000602107.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000602107.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000602107.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000932048.1","properties":[{"key":"ProteinId","value":"ENSP00000602107.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"OpenTargets","id":"ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"12"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"12"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"12"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"9"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1928,"molWeight":211003,"crc64":"445A99249CE30905","md5":"CEDBB3E98A19F5046ED3835EDEED2B47"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":14,"Disulfide bond":5},"uniParcId":"UPI0040316C17"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A7MBN2","uniProtkbId":"A7MBN2_HUMAN","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-10-02","entryVersion":101,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI51844.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI51844.1"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":1927,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5002713238"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":624,"modifier":"EXACT"},"end":{"value":714,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":804,"modifier":"EXACT"},"end":{"value":893,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":1074,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1075,"modifier":"EXACT"},"end":{"value":1164,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1166,"modifier":"EXACT"},"end":{"value":1256,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1257,"modifier":"EXACT"},"end":{"value":1349,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1438,"modifier":"EXACT"},"end":{"value":1527,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1528,"modifier":"EXACT"},"end":{"value":1614,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1615,"modifier":"EXACT"},"end":{"value":1703,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1701,"modifier":"EXACT"},"end":{"value":1916,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":393,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1862,"modifier":"EXACT"},"end":{"value":1875,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAI51844.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC151843","properties":[{"key":"ProteinId","value":"AAI51844.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"SMR","id":"A7MBN2","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TNC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"12"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"13"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"4"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"12"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"12"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"13"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"12"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"9"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"10"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGRGRCVNGQCVCHEGFMGKDCKGQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPAHVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLGSTDLPGLKAATHYTITIRGVTQDFSTTPLSVGVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAQALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1927,"molWeight":210489,"crc64":"12EF655F61614E2B","md5":"154663EEB58B310C53C1A27BCF4986DF"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":13,"Disulfide bond":5},"uniParcId":"UPI00015C002D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F5H7V9","uniProtkbId":"F5H7V9_HUMAN","entryAudit":{"firstPublicDate":"2011-06-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-06-28","entryVersion":111,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000442242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000442242.1"}],"value":"TNC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00063616"}],"value":"Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1773,"modifier":"EXACT"},"end":{"value":1786,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000442242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000442242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000442242.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000442242.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"SMR","id":"F5H7V9","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"F5H7V9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"F5H7V9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"27605","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"F5H7V9","properties":[{"key":"antibodies","value":"6 sequenced antibodies"}]},{"database":"Antibodypedia","id":"1348","properties":[{"key":"antibodies","value":"1069 antibodies from 46 providers"}]},{"database":"Ensembl","id":"ENST00000542877.6","properties":[{"key":"ProteinId","value":"ENSP00000442242.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"UCSC","id":"uc022bmj.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TNC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"Bgee","id":"ENSG00000041982","properties":[{"key":"ExpressionPatterns","value":"Expressed in saphenous vein and 187 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"F5H7V9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"10"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"11"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"11"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]},{"database":"SUPFAM","id":"SSF57196","properties":[{"key":"EntryName","value":"EGF/Laminin"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"8"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"10"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEPKPQLGTLIFSNITPKSFNMSWTTQAGLFAKIVINVSDAHSLHESQQFTVSGDAKQAHITGLVENTGYDVSVAGTTLAGDPTRPLTAFVITEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1838,"molWeight":201143,"crc64":"752819DBC1DEBD3E","md5":"422DF8A28394F8E0E72896E28AD8E4DB"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Disulfide bond":5},"uniParcId":"UPI000204A758"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"J3QSU6","uniProtkbId":"J3QSU6_HUMAN","entryAudit":{"firstPublicDate":"2012-10-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-10-03","entryVersion":93,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000339553.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00069274"}],"value":"Tenascin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00079678"}],"value":"Hexabrachion"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00080298"}],"value":"Tenascin-C"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000339553.4"}],"value":"TNC"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00063616"}],"value":"Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00008673"}],"value":"Belongs to the tenascin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":2019,"modifier":"EXACT"}},"description":"Tenascin","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003777214"},{"type":"Domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"EGF-like","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50026"}]},{"type":"Domain","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":895,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1076,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1167,"modifier":"EXACT"},"end":{"value":1259,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1349,"modifier":"EXACT"},"end":{"value":1438,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1440,"modifier":"EXACT"},"end":{"value":1529,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1530,"modifier":"EXACT"},"end":{"value":1619,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1620,"modifier":"EXACT"},"end":{"value":1706,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1707,"modifier":"EXACT"},"end":{"value":1795,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":1793,"modifier":"EXACT"},"end":{"value":2008,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}]},{"type":"Disulfide bond","location":{"start":{"value":1954,"modifier":"EXACT"},"end":{"value":1967,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023054"}],"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00076"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022974"}],"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"J3QSU6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"J3QSU6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000339553.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000339553.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000339553.4"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":6,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000339553.4"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001397920.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001410991.1"}]},{"database":"RefSeq","id":"NP_001426012.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001439083.1"}]},{"database":"SMR","id":"J3QSU6","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"J3QSU6","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"J3QSU6","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1348","properties":[{"key":"antibodies","value":"1069 antibodies from 46 providers"}]},{"database":"DNASU","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000341037.8","properties":[{"key":"ProteinId","value":"ENSP00000339553.4"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"GeneID","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc064vgq.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3371","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"3371","properties":[{"key":"hits","value":"10 hits in 1156 CRISPR screens"}]},{"database":"ChiTaRS","id":"TNC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"Bgee","id":"ENSG00000041982","properties":[{"key":"ExpressionPatterns","value":"Expressed in saphenous vein and 187 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"J3QSU6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd00054","properties":[{"key":"EntryName","value":"EGF_CA"},{"key":"MatchStatus","value":"3"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"12"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000099","properties":[{"key":"EntryName","value":"Fibronectin 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.25.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"14"}]},{"database":"FunFam","id":"2.20.25.10:FF:000006","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000162","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000201","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000207","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000293","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.20.25.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"13"}]},{"database":"Gene3D","id":"2.10.25.10","properties":[{"key":"EntryName","value":"Laminin"},{"key":"MatchStatus","value":"14"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR000742","properties":[{"key":"EntryName","value":"EGF"}]},{"database":"InterPro","id":"IPR013111","properties":[{"key":"EntryName","value":"EGF_extracell"}]},{"database":"InterPro","id":"IPR041161","properties":[{"key":"EntryName","value":"EGF_Tenascin"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07974","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25024","properties":[{"key":"EntryName","value":"EGF_TEN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18720","properties":[{"key":"EntryName","value":"EGF_Tenascin"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23106","properties":[{"key":"EntryName","value":"EGF_Teneurin"},{"key":"MatchStatus","value":"3"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"13"}]},{"database":"SMART","id":"SM00181","properties":[{"key":"EntryName","value":"EGF"},{"key":"MatchStatus","value":"14"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"13"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"10"}]},{"database":"PROSITE","id":"PS00022","properties":[{"key":"EntryName","value":"EGF_1"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS01186","properties":[{"key":"EntryName","value":"EGF_2"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50026","properties":[{"key":"EntryName","value":"EGF_3"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"11"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":2019,"molWeight":220853,"crc64":"8390133DD3663EE9","md5":"F61E154C5E741B64657DBA5F2BF7CCE2"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":14,"Disulfide bond":5},"uniParcId":"UPI000204A757"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A9YUB8","uniProtkbId":"A9YUB8_HUMAN","entryAudit":{"firstPublicDate":"2008-02-05","lastAnnotationUpdateDate":"2025-02-05","lastSequenceUpdateDate":"2008-02-05","entryVersion":48,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABX89318.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABX89318.1"}],"value":"Tenascin-C additional domain 1"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABX89318.1"}],"value":"TNC"}}],"features":[{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABX89318.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABX89318.1"}]}],"references":[{"referenceNumber":1,"citation":{"id":"CI-CSAKPRPP5IRJL","citationType":"submission","authors":["Guttery D.S.","Hancox R.A."],"publicationDate":"NOV-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ABX89318.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"EU295718","properties":[{"key":"ProteinId","value":"ABX89318.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"A9YUB8","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"A9YUB8","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TNC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"PKPQLGTLIFSNITPKSFNMSWTTQAGLFAKIVINVSDAHSLHESQQFTVSGDAKQAHITGLVENTGYDVSVAGTTLAGDPTRPLTAFVIT","length":91,"molWeight":9659,"crc64":"2BCE2F936A0943B1","md5":"29B00A8FB011471264A67CBE27FAFCC1"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI000162B445"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A994J510","uniProtkbId":"A0A994J510_HUMAN","entryAudit":{"firstPublicDate":"2023-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-05-03","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516087.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516087.1"}],"value":"Tenascin C"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516087.1"}],"value":"TNC"}}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516087.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516087.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A994J510"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A994J510"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516087.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516087.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516087.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516087.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000473855.1","properties":[{"key":"ProteinId","value":"ENSP00000516087.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"ExpressionAtlas","id":"A0A994J510","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"XRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIE","length":129,"molWeight":14556,"crc64":"1592767DE0978DF8","md5":"C94AAFFB130444384AC7E260B33CA856"},"extraAttributes":{"countByFeatureType":{"Domain":1,"Non-terminal residue":2},"uniParcId":"UPI0021EBD919"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A994J7R0","uniProtkbId":"A0A994J7R0_HUMAN","entryAudit":{"firstPublicDate":"2023-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-05-03","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516083.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516083.1"}],"value":"Tenascin C"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516083.1"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":512,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":603,"modifier":"EXACT"},"end":{"value":692,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":693,"modifier":"EXACT"},"end":{"value":782,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":783,"modifier":"EXACT"},"end":{"value":869,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":870,"modifier":"EXACT"},"end":{"value":958,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":956,"modifier":"EXACT"},"end":{"value":1171,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":1117,"modifier":"EXACT"},"end":{"value":1130,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516083.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A994J7R0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A994J7R0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516083.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516083.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516083.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516083.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A994J7R0","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000705190.1","properties":[{"key":"ProteinId","value":"ENSP00000516083.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"ExpressionAtlas","id":"A0A994J7R0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"9"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000610","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000939","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"11"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"10"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"10"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"9"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"9"}]}],"sequence":{"value":"ANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTVAKPLLSHLTVSNMTWGSVSISWEAQESAFDSFLIEVSNSDHPHETMVLSVPGVSRSSVITNLKASSNYTAHLHGLIGGQRAQTLMVQATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":1182,"molWeight":129419,"crc64":"C2693B78AC7783A1","md5":"C157EC4FCEA4BFBC8904AF16C5C472CF"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Domain":10,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI0021EB5686"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A994J5G0","uniProtkbId":"A0A994J5G0_HUMAN","entryAudit":{"firstPublicDate":"2023-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-05-03","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516086.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516086.1"}],"value":"Tenascin C"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516086.1"}],"value":"TNC"}}],"features":[{"type":"Domain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":110,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516086.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516086.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A994J5G0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A994J5G0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516086.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516086.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516086.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516086.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000476680.2","properties":[{"key":"ProteinId","value":"ENSP00000516086.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"ExpressionAtlas","id":"A0A994J5G0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"2"}]},{"database":"FunFam","id":"2.60.40.10:FF:000346","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"XQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTD","length":254,"molWeight":27398,"crc64":"6313DD7A1581FD3A","md5":"963BC4AC15BA6B7427B3F246C5750B53"},"extraAttributes":{"countByFeatureType":{"Domain":2,"Non-terminal residue":2},"uniParcId":"UPI0021EBE035"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A994J7R4","uniProtkbId":"A0A994J7R4_HUMAN","entryAudit":{"firstPublicDate":"2023-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-05-03","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516088.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516088.1"}],"value":"Tenascin C"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516088.1"}],"value":"TNC"}}],"features":[{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516088.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516088.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A994J7R4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A994J7R4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516088.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516088.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516088.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516088.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A994J7R4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A994J7R4","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000481475.1","properties":[{"key":"ProteinId","value":"ENSP00000516088.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"ExpressionAtlas","id":"A0A994J7R4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"3"}]},{"database":"FunFam","id":"2.60.40.10:FF:000610","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"3"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"3"}]}],"sequence":{"value":"VAKPLLSHLTVSNMTWGSVSISWEAQESAFDSFLIEVSNSDHPHETMVLSVPGVSRSSVITNLKASSNYTAHLHGLIGGQRAQTLMVQATTEPKPQLGTLIFSNITPKSFNMSWTTQAGLFAKIVINVSDAHSLHESQQFTVSGDAKQAHITGLVENTGYDVSVAGTTLAGDPTRPLTAFVITEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVT","length":274,"molWeight":29520,"crc64":"764B72DF6343AB09","md5":"ED3C7F1A56A112DED3C92241025CA0D9"},"extraAttributes":{"countByFeatureType":{"Domain":3,"Non-terminal residue":2},"uniParcId":"UPI0021EB62DD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"F5H5D6","uniProtkbId":"F5H5D6_HUMAN","entryAudit":{"firstPublicDate":"2011-06-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-06-28","entryVersion":87,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000443469.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000443469.1"}],"value":"Tenascin C"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000443469.1"}],"value":"TNC"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5003323088"},{"type":"Region","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000443469.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"F5H5D6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"F5H5D6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000443469.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000443469.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000443469.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000443469.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"F5H5D6","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"F5H5D6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"26847","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1348","properties":[{"key":"antibodies","value":"1069 antibodies from 46 providers"}]},{"database":"Ensembl","id":"ENST00000534839.1","properties":[{"key":"ProteinId","value":"ENSP00000443469.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"UCSC","id":"uc064vgz.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2418759_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HHNGRCE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TNC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"Bgee","id":"ENSG00000041982","properties":[{"key":"ExpressionPatterns","value":"Expressed in saphenous vein and 187 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"F5H5D6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTV","length":92,"molWeight":9861,"crc64":"92F741F1D0CC5C02","md5":"49F6DA68BD35E63CA19246B5E732DCFF"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Non-terminal residue":1},"uniParcId":"UPI000204A75A"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A0U1RR80","uniProtkbId":"A0A0U1RR80_HUMAN","entryAudit":{"firstPublicDate":"2016-02-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2016-02-17","entryVersion":45,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489385.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489385.1"}],"value":"Tenascin C"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489385.1"}],"value":"TNC"}}],"features":[{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489385.1"}]},{"type":"Non-terminal residue","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489385.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A0U1RR80"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A0U1RR80"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489385.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489385.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489385.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000489385.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A0U1RR80","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"A0A0U1RR80","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1348","properties":[{"key":"antibodies","value":"1069 antibodies from 46 providers"}]},{"database":"Ensembl","id":"ENST00000635336.1","properties":[{"key":"ProteinId","value":"ENSP00000489385.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000041982","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"TNC","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"Bgee","id":"ENSG00000041982","properties":[{"key":"ExpressionPatterns","value":"Expressed in saphenous vein and 187 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A0U1RR80","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]}],"sequence":{"value":"ASTEAEPEVDNLLVSDATPDGFR","length":23,"molWeight":2434,"crc64":"B63F059FE10C0A96","md5":"72EFCEBA9D2D70E024A93B43C551E24D"},"extraAttributes":{"countByFeatureType":{"Region":1,"Non-terminal residue":2},"uniParcId":"UPI000719A13C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A994J4S6","uniProtkbId":"A0A994J4S6_HUMAN","entryAudit":{"firstPublicDate":"2023-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2023-05-03","entryVersion":17,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516084.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516084.1"}],"value":"Tenascin C"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516084.1"}],"value":"TNC"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004498"}],"value":"Secreted, extracellular space, extracellular matrix","id":"SL-0111"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"value":"Lacks conserved residue(s) required for the propagation of feature annotation"}],"commentType":"CAUTION"}],"features":[{"type":"Domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":421,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":510,"modifier":"EXACT"}},"description":"Fibronectin type-III","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50853"}]},{"type":"Domain","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":723,"modifier":"EXACT"}},"description":"Fibrinogen C-terminal","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS51406"}]},{"type":"Disulfide bond","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":682,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}]},{"type":"Non-terminal residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516084.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023157"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00739"}],"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022536"}],"id":"KW-0245","category":"Domain","name":"EGF-like domain"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0272","category":"Cellular component","name":"Extracellular matrix"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A994J4S6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A994J4S6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022530"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516084.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516084.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516084.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000516084.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL162425","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A994J4S6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"A0A994J4S6","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000705191.1","properties":[{"key":"ProteinId","value":"ENSP00000516084.1"},{"key":"GeneId","value":"ENSG00000041982.18"}]},{"database":"HGNC","id":"HGNC:5318","properties":[{"key":"GeneName","value":"TNC"}]},{"database":"GeneTree","id":"ENSGT00940000155188","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"442731at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"ExpressionAtlas","id":"A0A994J4S6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"CDD","id":"cd00063","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"6"}]},{"database":"CDD","id":"cd00087","properties":[{"key":"EntryName","value":"FReD"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000274","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000398","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000529","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000610","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.10:FF:000611","properties":[{"key":"EntryName","value":"Tenascin C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.90.215.10:FF:000001","properties":[{"key":"EntryName","value":"Tenascin isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.215.10","properties":[{"key":"EntryName","value":"Gamma Fibrinogen, chain A, domain 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"6"}]},{"database":"InterPro","id":"IPR050991","properties":[{"key":"EntryName","value":"ECM_Regulatory_Proteins"}]},{"database":"InterPro","id":"IPR036056","properties":[{"key":"EntryName","value":"Fibrinogen-like_C"}]},{"database":"InterPro","id":"IPR014716","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_1"}]},{"database":"InterPro","id":"IPR002181","properties":[{"key":"EntryName","value":"Fibrinogen_a/b/g_C_dom"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"NCBIfam","id":"NF040941","properties":[{"key":"EntryName","value":"GGGWT_bact"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46708:SF1","properties":[{"key":"EntryName","value":"TENASCIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00147","properties":[{"key":"EntryName","value":"Fibrinogen_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00041","properties":[{"key":"EntryName","value":"fn3"},{"key":"MatchStatus","value":"5"}]},{"database":"SMART","id":"SM00186","properties":[{"key":"EntryName","value":"FBG"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"5"}]},{"database":"SUPFAM","id":"SSF56496","properties":[{"key":"EntryName","value":"Fibrinogen C-terminal domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS51406","properties":[{"key":"EntryName","value":"FIBRINOGEN_C_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50853","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"5"}]}],"sequence":{"value":"DRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA","length":734,"molWeight":81515,"crc64":"848C717C4945620B","md5":"F8C80AEFACB07E83A496BA1D9AF90FCC"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"CAUTION":1},"countByFeatureType":{"Domain":6,"Disulfide bond":1,"Non-terminal residue":1},"uniParcId":"UPI0021EBB7A8"}}]}