{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9UDY2","secondaryAccessions":["A2A3H9","B7Z2R8","B7Z7T6","F5H301","F5H886","Q15883","Q5VXL0","Q5VXL1","Q8N756","Q8NI14","Q99839","Q9UDY0","Q9UDY1"],"uniProtkbId":"ZO2_HUMAN","entryAudit":{"firstPublicDate":"2001-04-27","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-01-11","entryVersion":241,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:11828"}],"value":"Tight junction protein 2"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"value":"Tight junction protein ZO-2"}},{"fullName":{"value":"Zona occludens protein 2"}},{"fullName":{"value":"Zonula occludens protein 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:11828"}],"value":"TJP2"},"synonyms":[{"value":"X104"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"value":"ZO2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0U1"}],"value":"Plays a role in tight junctions and adherens junctions (By similarity). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q95168"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0U1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12704386"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15975580"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17897942"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18823282"}],"value":"Homodimer (PubMed:17897942). Interacts (via PDZ2 domain) with TJP1/ZO1 (via PDZ2 domain) (PubMed:17897942). Interacts with OCLN (By similarity). Interacts with UBN1 (PubMed:18823282). Interacts with SAFB in the nucleus (By similarity). Interacts with SCRIB (PubMed:15975580). Interacts with USP53 (via the C-terminal region) (By similarity). Interacts with claudins, including CLDN1, CLDN2, CLDN3, CLDN5 and CLDN7 (PubMed:12704386). Interacts with CLDN18 (By similarity). Interacts (via N-terminus) with CTNNA1 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"O15439","geneName":"ABCC4","intActId":"EBI-4319622"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"O96018","geneName":"APBA3","intActId":"EBI-6115839"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q5VV41","geneName":"ARHGEF16","intActId":"EBI-1057448"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q9UHC3","geneName":"ASIC3","intActId":"EBI-66903811"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"P23634","geneName":"ATP2B4","intActId":"EBI-1174388"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"P13569","geneName":"CFTR","intActId":"EBI-349854"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q9NS75","geneName":"CYSLTR2","intActId":"EBI-3843579"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"O60759","geneName":"CYTIP","intActId":"EBI-997814"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q5KSL6","geneName":"DGKK","intActId":"EBI-4401920"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q13574","geneName":"DGKZ","intActId":"EBI-715507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q8TDM6","geneName":"DLG5","intActId":"EBI-715138"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q8N1I0","geneName":"DOCK4","intActId":"EBI-1059186"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q92800","geneName":"EZH1","intActId":"EBI-8830732"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q5SYB0","geneName":"FRMPD1","intActId":"EBI-10245120"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q14CM0","geneName":"FRMPD4","intActId":"EBI-311279"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"O75084","geneName":"FZD7","intActId":"EBI-746917"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9UDY2","intActId":"EBI-1042602"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"n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Localizes to tight junctions during initial stages of their formation (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0U1"}],"value":"Cell junction, adherens junction","id":"SL-0009"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasmic side","id":"SL-9910"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0U1"}],"value":"Cell junction, tight junction","id":"SL-0265"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative promoter usage","Alternative splicing"],"isoforms":[{"name":{"value":"A1"},"isoformIds":["Q9UDY2-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"A2"},"isoformIds":["Q9UDY2-2"],"sequenceIds":["VSP_003149"],"isoformSequenceStatus":"Described"},{"name":{"value":"A3"},"isoformIds":["Q9UDY2-5"],"sequenceIds":["VSP_007835","VSP_007836"],"isoformSequenceStatus":"Described"},{"name":{"value":"C1"},"isoformIds":["Q9UDY2-3"],"sequenceIds":["VSP_006953"],"isoformSequenceStatus":"Described"},{"name":{"value":"C2"},"isoformIds":["Q9UDY2-4"],"sequenceIds":["VSP_006953","VSP_003149"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"isoformIds":["Q9UDY2-6"],"sequenceIds":["VSP_046115","VSP_046116"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"isoformIds":["Q9UDY2-7"],"sequenceIds":["VSP_046114"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11018256"}],"value":"This protein is found in epithelial cell junctions. 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