{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P54274","secondaryAccessions":["A7XP29","Q15553","Q8NHT6","Q93029"],"uniProtkbId":"TERF1_HUMAN","entryAudit":{"firstPublicDate":"1996-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-09-23","entryVersion":252,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Telomeric repeat-binding factor 1"}},"alternativeNames":[{"fullName":{"value":"NIMA-interacting protein 2"}},{"fullName":{"value":"TTAGGG repeat-binding factor 1"}},{"fullName":{"value":"Telomeric protein Pin2/TRF1"}}]},"genes":[{"geneName":{"value":"TERF1"},"synonyms":[{"value":"PIN2"},{"value":"TRBF1"},{"value":"TRF"},{"value":"TRF1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16166375"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31595153"}],"value":"Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length (PubMed:31595153). Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24692559"}],"value":"Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with RLIM (via N-terminus). Interacts with FBXO4. Interaction with TINF2 protects against interaction with FBXO4 and subsequent polyubiquitination and proteasomal degradation. Interacts with GNL3L; this interaction promotes homodimerization. Interacts with TIN2. Interacts with RTEL1. Interactions with GNL3L and TIN2 are mutually exclusive. Interacts with CCDC79/TERB1 (By similarity). Interacts with TRIOBP isoform 1; mediates TERF1 localization to the centrosome (PubMed:24692559)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q9BWD1","geneName":"ACAT2","intActId":"EBI-1047273"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q03154","geneName":"ACY1","intActId":"EBI-742064"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q01433","geneName":"AMPD2","intActId":"EBI-8796759"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"P49418","geneName":"AMPH","intActId":"EBI-7121510"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q13315","geneName":"ATM","intActId":"EBI-495465"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"P54132","geneName":"BLM","intActId":"EBI-621372"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q6P2H3","geneName":"CEP85","intActId":"EBI-2808308"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q9BR76","geneName":"CORO1B","intActId":"EBI-351152"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"P53674","geneName":"CRYBB1","intActId":"EBI-7519424"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q14894","geneName":"CRYM","intActId":"EBI-7107048"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q96C57","geneName":"CUSTOS","intActId":"EBI-11305571"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q9UMR2","geneName":"DDX19B","intActId":"EBI-719232"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q9BUQ8","geneName":"DDX23","intActId":"EBI-540096"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"O00148","geneName":"DDX39A","intActId":"EBI-348253"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"P25685","geneName":"DNAJB1","intActId":"EBI-357034"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"O43598","geneName":"DNPH1","intActId":"EBI-748674"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q9H4G0","geneName":"EPB41L1","intActId":"EBI-465536"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q9UKT5-1","geneName":"FBXO4","intActId":"EBI-960421"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"P07332","geneName":"FES","intActId":"EBI-1055635"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"P48637","geneName":"GSS","intActId":"EBI-2969145"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"P14317","geneName":"HCLS1","intActId":"EBI-750369"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q96MH2","geneName":"HEXIM2","intActId":"EBI-5460660"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P54274","intActId":"EBI-710997"},"interactantTwo":{"uniProtKBAccession":"Q93099","geneName":"HGD","intActId":"EBI-3907760"},"numberOfExperiments":2,"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