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Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10049359"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15848170"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16159890"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16251192"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17178713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18984161"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29186683"}],"value":"Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP (PubMed:15848170, PubMed:16159890, PubMed:17178713). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (PubMed:18984161). Associates with the SMN complex in the cytoplasm but not in the nucleus (PubMed:16159890). Interacts with GEMIN6; the interaction is direct (PubMed:15848170). Interacts with GEMIN7; the interaction is direct (PubMed:15848170, PubMed:17178713). Interacts with CSDE1/UNR and MAWBP (PubMed:10049359). Interacts with PDPK1 (PubMed:16251192). Interacts with TRIM48 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