{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P30874","secondaryAccessions":["A8K3Y0","B2R9P7","Q4VBP0","Q96GE0","Q96TF2","Q9BWH1"],"uniProtkbId":"SSR2_HUMAN","entryAudit":{"firstPublicDate":"1993-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1993-07-01","entryVersion":211,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Somatostatin receptor type 2"},"shortNames":[{"value":"SS-2-R"},{"value":"SS2-R"},{"value":"SS2R"},{"value":"SST2"}]},"alternativeNames":[{"fullName":{"value":"SRIF-1"}}]},"genes":[{"geneName":{"value":"SSTR2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15231824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18653781"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19434240"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22495673"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22932785"}],"value":"Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10551867"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15231824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18653781"}],"value":"Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P30874","intActId":"EBI-6266898"},"interactantTwo":{"uniProtKBAccession":"P27986","geneName":"PIK3R1","intActId":"EBI-79464"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P30874","intActId":"EBI-6266898"},"interactantTwo":{"uniProtKBAccession":"P32745","geneName":"SSTR3","intActId":"EBI-6266935"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P30874","intActId":"EBI-6266898"},"interactantTwo":{"uniProtKBAccession":"P35346","geneName":"SSTR5","intActId":"EBI-27053622"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm"}]},"subcellularLocations":[{"location":{"value":"Cell membrane","id":"SL-0039"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"A"},"synonyms":[{"value":"SSTR2A"}],"isoformIds":["P30874-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"B"},"synonyms":[{"value":"SSTR2B"}],"isoformIds":["P30874-2"],"sequenceIds":["VSP_001922"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19434240"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22932785"}],"value":"Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}],"value":"Belongs to the G protein-coupled receptor 1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"Somatostatin receptor type 2","featureId":"PRO_0000070120"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":79,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":279,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":289,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":304,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Site","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Important for ligand binding"},{"type":"Modified residue","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30680"}]},{"type":"Modified residue","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30680"}]},{"type":"Modified residue","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30680"}]},{"type":"Modified residue","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":353,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30680"}]},{"type":"Modified residue","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P30680"}]},{"type":"Lipidation","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Glycosylation","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00521"}]},{"type":"Alternative sequence","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"in isoform B","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_001922","alternativeSequence":{"originalSequence":"VSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI","alternativeSequences":["VDNSKSGEEGSCLDMIFRNNKNRKK"]}},{"type":"Mutagenesis","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Expression levels reduced by 60%.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22495673"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Expression levels reduced by 80%.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22495673"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Slightly reduced expression levels. Remains localized in membrane. Abolishes ligand binding and G protein-mediated calcium release.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22495673"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"Expression levels reduced by 50%. Significantly reduced ligand binding capacity but increased affinity. Reduced G protein-mediated cAMP release but no effect on G protein mediated calcium release.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22495673"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"Expression levels reduced by 40%. No significant change in ligand binding capacity or affinity. Reduced G protein-mediated cAMP signaling but no effect on G protein-mediated calcium release.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22495673"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Slightly reduced expression levels. No significant change in ligand binding capacity or affinity. No significant change in G protein-mediated cAMP or calcium release.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22495673"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Almost abolishes expression. Abolishes membrane localization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22495673"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["E"]}},{"type":"Mutagenesis","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Slightly reduced expression levels. Significantly reduced ligand binding capacity but increased affinity. Reduced G protein-mediated cAMP release but no effect on G protein-mediated calcium release.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22495673"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"in Ref. 5; BAG36594","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":122,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"in Ref. 5; BAG36594","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"in Ref. 5; BAG36594","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Helix","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Turn","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XAU"}]},{"type":"Beta strand","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WIC"}]},{"type":"Helix","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Y26"}]},{"type":"Helix","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Beta strand","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":175,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Beta strand","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Beta strand","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XAT"}]},{"type":"Beta strand","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Turn","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":203,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XMR"}]},{"type":"Helix","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XAT"}]},{"type":"Helix","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XAV"}]},{"type":"Helix","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":286,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7WIC"}]},{"type":"Helix","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]},{"type":"Helix","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7Y26"}]},{"type":"Helix","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":326,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7T10"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0297","category":"Molecular function","name":"G protein-coupled receptor"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-0675","category":"Molecular function","name":"Receptor"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0807","category":"Molecular function","name":"Transducer"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"1346068","citationType":"journal article","authors":["Yamada Y.","Post S.R.","Wang K.","Tager H.S.","Bell G.I.","Seino S."],"citationCrossReferences":[{"database":"PubMed","id":"1346068"},{"database":"DOI","id":"10.1073/pnas.89.1.251"}],"title":"Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"251","lastPage":"255","volume":"89"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A)"]},{"referenceNumber":2,"citation":{"id":"10619399","citationType":"journal article","authors":["Petersenn S.","Rasch A.C.","Presch S.","Beil F.U.","Schulte H.M."],"citationCrossReferences":[{"database":"PubMed","id":"10619399"},{"database":"DOI","id":"10.1016/s0303-7207(99)00161-6"}],"title":"Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.","publicationDate":"1999","journal":"Mol. Cell. Endocrinol.","firstPage":"75","lastPage":"85","volume":"157"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B)"]},{"referenceNumber":3,"citation":{"id":"CI-5ONEO2UD4TNKJ","citationType":"submission","authors":["Kopatz S.A.","Aronstam R.S.","Sharma S.V."],"title":"Isolation of complete coding sequence for somatostatin receptor 2 (SSTR2).","publicationDate":"FEB-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-BG5VJBS1LMLCE","citationType":"submission","authors":["Suwa M.","Sato T.","Okouchi I.","Arita M.","Futami K.","Matsumoto S.","Tsutsumi S.","Aburatani H.","Asai K.","Akiyama Y."],"title":"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes.","publicationDate":"JUL-2001","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)"]},{"referenceNumber":6,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)"],"referenceComments":[{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"8386508","citationType":"journal article","authors":["Patel Y.C.","Greenwood M.","Kent G.","Panetta R.","Srikant C.B."],"citationCrossReferences":[{"database":"PubMed","id":"8386508"},{"database":"DOI","id":"10.1006/bbrc.1993.1412"}],"title":"Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.","publicationDate":"1993","journal":"Biochem. Biophys. Res. Commun.","firstPage":"288","lastPage":"294","volume":"192"},"referencePositions":["ALTERNATIVE SPLICING (ISOFORMS A AND B)"]},{"referenceNumber":9,"citation":{"id":"10551867","citationType":"journal article","authors":["Zitzer H.","Hoenck H.-H.","Baechner D.","Richter D.","Kreienkamp H.-J."],"citationCrossReferences":[{"database":"PubMed","id":"10551867"},{"database":"DOI","id":"10.1074/jbc.274.46.32997"}],"title":"Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.","publicationDate":"1999","journal":"J. Biol. Chem.","firstPage":"32997","lastPage":"33001","volume":"274"},"referencePositions":["INTERACTION WITH SHANK1"]},{"referenceNumber":10,"citation":{"id":"15231824","citationType":"journal article","authors":["Grant M.","Collier B.","Kumar U."],"citationCrossReferences":[{"database":"PubMed","id":"15231824"},{"database":"DOI","id":"10.1074/jbc.m407310200"}],"title":"Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"36179","lastPage":"36183","volume":"279"},"referencePositions":["FUNCTION","SUBUNIT","SUBCELLULAR LOCATION"]},{"referenceNumber":11,"citation":{"id":"18653781","citationType":"journal article","authors":["Grant M.","Alturaihi H.","Jaquet P.","Collier B.","Kumar U."],"citationCrossReferences":[{"database":"PubMed","id":"18653781"},{"database":"DOI","id":"10.1210/me.2007-0334"}],"title":"Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization.","publicationDate":"2008","journal":"Mol. Endocrinol.","firstPage":"2278","lastPage":"2292","volume":"22"},"referencePositions":["FUNCTION","SUBUNIT","INTERACTION WITH BETA-ARRESTIN","SUBCELLULAR LOCATION"]},{"referenceNumber":12,"citation":{"id":"19434240","citationType":"journal article","authors":["Le Verche V.","Kaindl A.M.","Verney C.","Csaba Z.","Peineau S.","Olivier P.","Adle-Biassette H.","Leterrier C.","Vitalis T.","Renaud J.","Dargent B.","Gressens P.","Dournaud P."],"citationCrossReferences":[{"database":"PubMed","id":"19434240"},{"database":"DOI","id":"10.1371/journal.pone.0005509"}],"title":"The somatostatin 2A receptor is enriched in migrating neurons during rat and human brain development and stimulates migration and axonal outgrowth.","publicationDate":"2009","journal":"PLoS ONE","firstPage":"E5509","lastPage":"E5509","volume":"4"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":13,"citation":{"id":"22932785","citationType":"journal article","authors":["Kailey B.","van de Bunt M.","Cheley S.","Johnson P.R.","MacDonald P.E.","Gloyn A.L.","Rorsman P.","Braun M."],"citationCrossReferences":[{"database":"PubMed","id":"22932785"},{"database":"DOI","id":"10.1152/ajpendo.00207.2012"}],"title":"SSTR2 is the functionally dominant somatostatin receptor in human pancreatic beta- and alpha-cells.","publicationDate":"2012","journal":"Am. J. Physiol.","firstPage":"E1107","lastPage":"E1116","volume":"303"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]},{"referenceNumber":14,"citation":{"id":"22495673","citationType":"journal article","authors":["Parry J.J.","Chen R.","Andrews R.","Lears K.A.","Rogers B.E."],"citationCrossReferences":[{"database":"PubMed","id":"22495673"},{"database":"DOI","id":"10.1210/en.2011-1662"}],"title":"Identification of critical residues involved in ligand binding and G protein signaling in human somatostatin receptor subtype 2.","publicationDate":"2012","journal":"Endocrinology","firstPage":"2747","lastPage":"2755","volume":"153"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","MUTAGENESIS OF ASP-89; ASP-139 AND ARG-140"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M81830","properties":[{"key":"ProteinId","value":"AAA58248.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY236542","properties":[{"key":"ProteinId","value":"AAO92064.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF184174","properties":[{"key":"ProteinId","value":"AAF42809.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF184174","properties":[{"key":"ProteinId","value":"AAF42810.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB065911","properties":[{"key":"ProteinId","value":"BAC06126.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK290745","properties":[{"key":"ProteinId","value":"BAF83434.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK313866","properties":[{"key":"ProteinId","value":"BAG36594.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT019926","properties":[{"key":"ProteinId","value":"AAV38729.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC000256","properties":[{"key":"ProteinId","value":"AAH00256.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC009522","properties":[{"key":"ProteinId","value":"AAH09522.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC019610","properties":[{"key":"ProteinId","value":"AAH19610.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC095495","properties":[{"key":"ProteinId","value":"AAH95495.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS11691.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P30874-1"},{"database":"PIR","id":"B41795","properties":[{"key":"EntryName","value":"B41795"}]},{"database":"RefSeq","id":"NP_001041.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001050.3"}],"isoformId":"P30874-1"},{"database":"PDB","id":"7T10","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"R=1-237, R=253-369"}]},{"database":"PDB","id":"7T11","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"R=1-237, R=253-369"}]},{"database":"PDB","id":"7UL5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A=1-237, A=254-369"}]},{"database":"PDB","id":"7WIC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"R=1-369"}]},{"database":"PDB","id":"7WIG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"R=1-369"}]},{"database":"PDB","id":"7WJ5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.72 A"},{"key":"Chains","value":"R=1-369"}]},{"database":"PDB","id":"7XAT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.85 A"},{"key":"Chains","value":"A=1-361"}]},{"database":"PDB","id":"7XAU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.97 A"},{"key":"Chains","value":"A=1-361"}]},{"database":"PDB","id":"7XAV","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.87 A"},{"key":"Chains","value":"A=1-361"}]},{"database":"PDB","id":"7XMR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"R=2-359"}]},{"database":"PDB","id":"7XN9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A=2-239, A=243-359"}]},{"database":"PDB","id":"7XNA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.65 A"},{"key":"Chains","value":"A=2-237, A=244-359"}]},{"database":"PDB","id":"7Y24","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.25 A"},{"key":"Chains","value":"E=1-327"}]},{"database":"PDB","id":"7Y26","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"E=1-337"}]},{"database":"PDB","id":"7Y27","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.48 A"},{"key":"Chains","value":"E=1-337"}]},{"database":"PDB","id":"7YAC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.24 A"},{"key":"Chains","value":"E=31-338"}]},{"database":"PDB","id":"7YAE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.37 A"},{"key":"Chains","value":"E=1-369"}]},{"database":"PDBsum","id":"7T10","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7T11","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UL5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WIC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WIG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7WJ5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XAT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XAU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XAV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XMR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XN9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XNA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7Y24","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7Y26","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7Y27","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7YAC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7YAE","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-25586","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26592","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32528","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32529","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-32543","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33098","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33099","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33100","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33302","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33585","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33586","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33587","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33708","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-33710","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112630","properties":[{"key":"Interactions","value":"63"}]},{"database":"CORUM","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P30874","properties":[{"key":"Number of interactors","value":"1037"}]},{"database":"IntAct","id":"P30874","properties":[{"key":"Interactions","value":"39"}]},{"database":"MINT","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-SSTR2","properties":[{"key":"Evidences","value":"6 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000350198","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1804","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB15873","properties":[{"key":"GenericName","value":"Copper oxodotreotide Cu-64"}]},{"database":"DrugBank","id":"DB16144","properties":[{"key":"GenericName","value":"Dopastatin"}]},{"database":"DrugBank","id":"DB13925","properties":[{"key":"GenericName","value":"Dotatate gallium Ga-68"}]},{"database":"DrugBank","id":"DB15494","properties":[{"key":"GenericName","value":"Edotreotide gallium Ga-68"}]},{"database":"DrugBank","id":"DB06791","properties":[{"key":"GenericName","value":"Lanreotide"}]},{"database":"DrugBank","id":"DB13985","properties":[{"key":"GenericName","value":"Lutetium Lu 177 dotatate"}]},{"database":"DrugBank","id":"DB18351","properties":[{"key":"GenericName","value":"Nendratareotide uzatansine"}]},{"database":"DrugBank","id":"DB00104","properties":[{"key":"GenericName","value":"Octreotide"}]},{"database":"DrugBank","id":"DB16277","properties":[{"key":"GenericName","value":"Paltusotine"}]},{"database":"DrugBank","id":"DB06663","properties":[{"key":"GenericName","value":"Pasireotide"}]},{"database":"DrugBank","id":"DB09099","properties":[{"key":"GenericName","value":"Somatostatin"}]},{"database":"DrugBank","id":"DB04894","properties":[{"key":"GenericName","value":"Vapreotide"}]},{"database":"DrugCentral","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"356","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"P30874","properties":[{"key":"glycosylation","value":"4 sites, No reported glycans"}]},{"database":"GlyGen","id":"P30874","properties":[{"key":"glycosylation","value":"5 sites"}]},{"database":"iPTMnet","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SSTR2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"401126","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000350198","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54743","properties":[{"key":"Description","value":"-"}],"isoformId":"P30874-1"},{"database":"ProteomicsDB","id":"54744","properties":[{"key":"Description","value":"-"}],"isoformId":"P30874-2"},{"database":"ABCD","id":"P30874","properties":[{"key":"antibodies","value":"8 sequenced antibodies"}]},{"database":"Antibodypedia","id":"1548","properties":[{"key":"antibodies","value":"423 antibodies from 40 providers"}]},{"database":"DNASU","id":"6752","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000357585.4","properties":[{"key":"ProteinId","value":"ENSP00000350198.2"},{"key":"GeneId","value":"ENSG00000180616.9"}],"isoformId":"P30874-1"},{"database":"GeneID","id":"6752","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6752","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000357585.4","properties":[{"key":"ProteinId","value":"ENSP00000350198.2"},{"key":"RefSeqNucleotideId","value":"NM_001050.3"},{"key":"RefSeqProteinId","value":"NP_001041.1"}]},{"database":"UCSC","id":"uc002jje.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P30874-1"},{"database":"AGR","id":"HGNC:11331","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA36155","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6752","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6752","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SSTR2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11331","properties":[{"key":"GeneName","value":"SSTR2"}]},{"database":"HPA","id":"ENSG00000180616","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain)"}]},{"database":"MIM","id":"182452","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000180616","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000180616","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3656","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156544","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_009579_8_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NGCFCTI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6076970at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P30874","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-375276","properties":[{"key":"PathwayName","value":"Peptide ligand-binding receptors"}]},{"database":"Reactome","id":"R-HSA-418594","properties":[{"key":"PathwayName","value":"G alpha (i) signalling events"}]},{"database":"SignaLink","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P30874","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000180616","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6752","properties":[{"key":"hits","value":"9 hits in 1155 CRISPR screens"}]},{"database":"ChiTaRS","id":"SSTR2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Somatostatin_receptor_2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6752","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P30874","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:P30874","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"P30874","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000180616","properties":[{"key":"ExpressionPatterns","value":"Expressed in buccal mucosa cell and 131 other cell types or tissues"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0043005","properties":[{"key":"GoTerm","value":"C:neuron projection"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042923","properties":[{"key":"GoTerm","value":"F:neuropeptide binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030165","properties":[{"key":"GoTerm","value":"F:PDZ domain binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"10551867"}]},{"database":"GO","id":"GO:0004994","properties":[{"key":"GoTerm","value":"F:somatostatin receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0071392","properties":[{"key":"GoTerm","value":"P:cellular response to estradiol stimulus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0071385","properties":[{"key":"GoTerm","value":"P:cellular response to glucocorticoid stimulus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007187","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"7914078"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9892014"}]},{"database":"GO","id":"GO:0007218","properties":[{"key":"GoTerm","value":"P:neuropeptide signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd15971","properties":[{"key":"EntryName","value":"7tmA_SSTR2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1070.10:FF:000039","properties":[{"key":"EntryName","value":"somatostatin receptor type 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1070.10","properties":[{"key":"EntryName","value":"Rhodopsin 7-helix transmembrane proteins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000276","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn"}]},{"database":"InterPro","id":"IPR017452","properties":[{"key":"EntryName","value":"GPCR_Rhodpsn_7TM"}]},{"database":"InterPro","id":"IPR000586","properties":[{"key":"EntryName","value":"Somatstn_rcpt"}]},{"database":"InterPro","id":"IPR002074","properties":[{"key":"EntryName","value":"Somatstn_rcpt_2"}]},{"database":"PANTHER","id":"PTHR24229","properties":[{"key":"EntryName","value":"NEUROPEPTIDES RECEPTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24229:SF6","properties":[{"key":"EntryName","value":"SOMATOSTATIN RECEPTOR TYPE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00001","properties":[{"key":"EntryName","value":"7tm_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00237","properties":[{"key":"EntryName","value":"GPCRRHODOPSN"}]},{"database":"PRINTS","id":"PR00246","properties":[{"key":"EntryName","value":"SOMATOSTATNR"}]},{"database":"PRINTS","id":"PR00588","properties":[{"key":"EntryName","value":"SOMATOSTTN2R"}]},{"database":"SMART","id":"SM01381","properties":[{"key":"EntryName","value":"7TM_GPCR_Srsx"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81321","properties":[{"key":"EntryName","value":"Family A G protein-coupled receptor-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00237","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50262","properties":[{"key":"EntryName","value":"G_PROTEIN_RECEP_F1_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI","length":369,"molWeight":41333,"crc64":"3B5D7D8A9AC246C6","md5":"1976D7F6D4FD016312F85779ADD2ECEA"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":7,"Site":1,"Modified residue":5,"Lipidation":1,"Glycosylation":4,"Disulfide bond":1,"Alternative sequence":1,"Mutagenesis":8,"Sequence conflict":3,"Helix":21,"Turn":2,"Beta strand":5},"uniParcId":"UPI0000000808"}}]}