{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P10451","secondaryAccessions":["B2RDA1","Q15681","Q15682","Q15683","Q4W597","Q567T5","Q8NBK2","Q96IZ1"],"uniProtkbId":"OSTP_HUMAN","entryAudit":{"firstPublicDate":"1989-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1989-07-01","entryVersion":246,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1974876"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"2726470"}],"value":"Osteopontin"}},"alternativeNames":[{"fullName":{"value":"Bone sialoprotein 1"}},{"fullName":{"value":"Nephropontin"}},{"fullName":{"value":"Secreted phosphoprotein 1"},"shortNames":[{"value":"SPP-1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1729712"}],"value":"Urinary stone protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1729712"}],"value":"Uropontin"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"SPP1"},"synonyms":[{"value":"BNSP"},{"value":"OPN"}],"orfNames":[{"value":"PSEC0156"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P31096"}],"value":"Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10923"}],"value":"Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10923"}],"value":"Interacts (via N-terminus) with integrin ITGA9:ITGB1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P10451","intActId":"EBI-723648"},"interactantTwo":{"uniProtKBAccession":"P46379-2","geneName":"BAG6","intActId":"EBI-10988864"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10451","intActId":"EBI-723648"},"interactantTwo":{"uniProtKBAccession":"Q8IXL6","geneName":"FAM20C","intActId":"EBI-7147442"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10451","intActId":"EBI-723648"},"interactantTwo":{"uniProtKBAccession":"O43681","geneName":"GET3","intActId":"EBI-2515857"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10451","intActId":"EBI-723648"},"interactantTwo":{"uniProtKBAccession":"P50222","geneName":"MEOX2","intActId":"EBI-748397"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10451","intActId":"EBI-723648"},"interactantTwo":{"uniProtKBAccession":"P62166","geneName":"NCS1","intActId":"EBI-746987"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10451","intActId":"EBI-723648"},"interactantTwo":{"uniProtKBAccession":"O43765","geneName":"SGTA","intActId":"EBI-347996"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P10451","intActId":"EBI-723648"},"interactantTwo":{"uniProtKBAccession":"Q96EQ0","geneName":"SGTB","intActId":"EBI-744081"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"chainId":"PRO_0000020321","intActId":"EBI-11893188"},"interactantTwo":{"uniProtKBAccession":"Q8IXL6","geneName":"FAM20C","intActId":"EBI-7147442"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25326458"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36213313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37453717"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"OPN-a"},{"value":"OP1B"}],"isoformIds":["P10451-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"3"},"synonyms":[{"value":"OPN-c"}],"isoformIds":["P10451-3"],"sequenceIds":["VSP_003777"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["P10451-4"],"sequenceIds":["VSP_011639"],"isoformSequenceStatus":"Described"},{"name":{"value":"2"},"synonyms":[{"value":"OPN-b"},{"value":"OP1A"}],"isoformIds":["P10451-5"],"sequenceIds":["VSP_043695"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25326458"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36213313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37453717"}],"value":"Detected in cerebrospinal fluid and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Bone. Found in plasma"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P31096"}],"value":"Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P10923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22582013"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}],"value":"Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif (PubMed:15869464, PubMed:22582013, PubMed:26091039). The phosphorylated form inhibits hydroxyapatite crystallization. Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization (By similarity)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23234360"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25326458"}],"value":"O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the osteopontin family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/42379/SPP1","ftp":false},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Osteopontin","ftp":false,"note":"Osteopontin entry"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"Osteopontin","featureId":"PRO_0000020321"},{"type":"Region","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"Cell attachment site"},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":78,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P31096"}]},{"type":"Modified residue","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16807684"}]},{"type":"Modified residue","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}]},{"type":"Modified residue","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Phosphothreonine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Phosphothreonine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":254,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":258,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":263,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":267,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":270,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":303,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":310,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Modified residue","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Phosphoserine; by FAM20C","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26091039"}]},{"type":"Glycosylation","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"O-linked (GalNAc...) threonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15869464"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"O-linked (Xyl...) (chondroitin sulfate) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25326458"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37453717"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"O-linked (Xyl...) (chondroitin sulfate) serine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25326458"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36213313"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37453717"}],"featureId":""},{"type":"Alternative sequence","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7837791"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.8"}],"featureId":"VSP_003777","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1974876"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7837791"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.7"}],"featureId":"VSP_043695","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16303743"}],"featureId":"VSP_011639","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":224,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"in dbSNP:rs7435825","featureCrossReferences":[{"database":"dbSNP","id":"rs7435825"}],"featureId":"VAR_050432","alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"in dbSNP:rs4660","featureCrossReferences":[{"database":"dbSNP","id":"rs4660"}],"featureId":"VAR_014717","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"in Ref. 6; BAA05950","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":188,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"in Ref. 6; BAA05949/BAA05950/BAA05951","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"in Ref. 6; BAA05949/BAA05950/BAA05951","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Beta strand","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3CXD"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0091","category":"Biological process","name":"Biomineralization"},{"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0654","category":"PTM","name":"Proteoglycan"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0730","category":"Ligand","name":"Sialic acid"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"2726470","citationType":"journal article","authors":["Kiefer M.C.","Bauer D.M.","Barr P.J."],"citationCrossReferences":[{"database":"PubMed","id":"2726470"},{"database":"DOI","id":"10.1093/nar/17.8.3306"}],"title":"The cDNA and derived amino acid sequence for human osteopontin.","publicationDate":"1989","journal":"Nucleic Acids Res.","firstPage":"3306","lastPage":"3306","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"1974876","citationType":"journal article","authors":["Young M.F.","Kerr J.M.","Termine J.D.","Wewer U.M.","Wang M.G.","McBride O.W.","Fisher L.W."],"citationCrossReferences":[{"database":"PubMed","id":"1974876"},{"database":"DOI","id":"10.1016/0888-7543(90)90191-v"}],"title":"cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN).","publicationDate":"1990","journal":"Genomics","firstPage":"491","lastPage":"502","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"]},{"referenceNumber":3,"citation":{"id":"1729712","citationType":"journal article","authors":["Shiraga H.","Min W.","VanDusen W.J.","Clayman M.D.","Miner D.","Terrell C.H.","Sherbotie J.R.","Foreman J.W.","Przysiecki C.","Neilson E.G.","Hoyer J.R."],"citationCrossReferences":[{"database":"PubMed","id":"1729712"},{"database":"DOI","id":"10.1073/pnas.89.1.426"}],"title":"Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"426","lastPage":"430","volume":"89"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"7665163","citationType":"journal article","authors":["Crosby A.H.","Edwards S.J.","Murray J.C.","Dixon M.J."],"citationCrossReferences":[{"database":"PubMed","id":"7665163"},{"database":"DOI","id":"10.1006/geno.1995.1018"}],"title":"Genomic organization of the human osteopontin gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II.","publicationDate":"1995","journal":"Genomics","firstPage":"155","lastPage":"160","volume":"27"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)"]},{"referenceNumber":5,"citation":{"id":"7945249","citationType":"journal article","authors":["Hijiya N.","Setoguchi M.","Matsuura K.","Higuchi Y.","Akizuki S.","Yamamoto S."],"citationCrossReferences":[{"database":"PubMed","id":"7945249"},{"database":"DOI","id":"10.1042/bj3030255"}],"title":"Cloning and characterization of the human osteopontin gene and its promoter.","publicationDate":"1994","journal":"Biochem. J.","firstPage":"255","lastPage":"262","volume":"303"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"7837791","citationType":"journal article","authors":["Saitoh Y.","Kuratsu J.","Takeshima H.","Yamamoto S.","Ushio Y."],"citationCrossReferences":[{"database":"PubMed","id":"7837791"}],"title":"Expression of osteopontin in human glioma. Its correlation with the malignancy.","publicationDate":"1995","journal":"Lab. Invest.","firstPage":"55","lastPage":"63","volume":"72"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)"]},{"referenceNumber":7,"citation":{"id":"CI-DPRM7C3CR257N","citationType":"submission","authors":["Yu W.","Sarginson J.","Gibbs R.A."],"publicationDate":"MAR-1998","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"CI-4549LQKVF147G","citationType":"submission","authors":["Sivakumar S.","Niranjali Devaraj S."],"title":"Osteopontin splice variants in Indian breast cancer patients as biomarker.","publicationDate":"FEB-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)"]},{"referenceNumber":9,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)"],"referenceComments":[{"value":"Kidney","type":"TISSUE"},{"value":"Subthalamic nucleus","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"16303743","citationType":"journal article","authors":["Otsuki T.","Ota T.","Nishikawa T.","Hayashi K.","Suzuki Y.","Yamamoto J.","Wakamatsu A.","Kimura K.","Sakamoto K.","Hatano N.","Kawai Y.","Ishii S.","Saito K.","Kojima S.","Sugiyama T.","Ono T.","Okano K.","Yoshikawa Y.","Aotsuka S.","Sasaki N.","Hattori A.","Okumura K.","Nagai K.","Sugano S.","Isogai T."],"citationCrossReferences":[{"database":"PubMed","id":"16303743"},{"database":"DOI","id":"10.1093/dnares/12.2.117"}],"title":"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.","publicationDate":"2005","journal":"DNA Res.","firstPage":"117","lastPage":"126","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"CI-2RSQ1QUN6TPB0","citationType":"submission","authors":["Yu Z.","Zheng Z.","Tang T.","Fu Y."],"title":"A computer system platform used to predict novel genes.","publicationDate":"JUL-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":12,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":13,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":14,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"1575754","citationType":"journal article","authors":["Kohri K.","Suzuki Y.","Yoshida K.","Yamamoto K.","Amasaki N.","Yamate T.","Umekawa T.","Iguchi M.","Sinohara H.","Kurita T."],"citationCrossReferences":[{"database":"PubMed","id":"1575754"},{"database":"DOI","id":"10.1016/0006-291x(92)90669-c"}],"title":"Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin.","publicationDate":"1992","journal":"Biochem. Biophys. Res. Commun.","firstPage":"859","lastPage":"864","volume":"184"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 67-278"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"2736258","citationType":"journal article","authors":["Senger D.R.","Perruzzi C.A.","Papadopoulos A.","Tenen D.G."],"citationCrossReferences":[{"database":"PubMed","id":"2736258"},{"database":"DOI","id":"10.1016/0167-4838(89)90092-7"}],"title":"Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin.","publicationDate":"1989","journal":"Biochim. Biophys. Acta","firstPage":"43","lastPage":"48","volume":"996"},"referencePositions":["PROTEIN SEQUENCE OF 17-23 AND 169-182"],"referenceComments":[{"value":"Milk","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"15869464","citationType":"journal article","authors":["Christensen B.","Nielsen M.S.","Haselmann K.F.","Petersen T.E.","Sorensen E.S."],"citationCrossReferences":[{"database":"PubMed","id":"15869464"},{"database":"DOI","id":"10.1042/bj20050341"}],"title":"Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications.","publicationDate":"2005","journal":"Biochem. J.","firstPage":"285","lastPage":"292","volume":"390"},"referencePositions":["PHOSPHORYLATION AT SER-24; SER-26; SER-27; SER-62; SER-63; THR-66; SER-76; SER-81; SER-99; SER-102; SER-108; SER-117; SER-120; SER-123; SER-129; THR-185; SER-191; SER-195; SER-215; SER-219; SER-224; SER-228; SER-234; SER-254; SER-263; SER-267; SER-275; SER-280; SER-303; SER-308; SER-310; SER-105 AND SER-126","GLYCOSYLATION AT THR-134; THR-138; THR-143; THR-147 AND THR-152"],"referenceComments":[{"value":"Milk","type":"TISSUE"}]},{"referenceNumber":18,"citation":{"id":"16807684","citationType":"journal article","authors":["Beranova-Giorgianni S.","Zhao Y.","Desiderio D.M.","Giorgianni F."],"citationCrossReferences":[{"database":"PubMed","id":"16807684"},{"database":"DOI","id":"10.1007/s11102-006-8916-x"}],"title":"Phosphoproteomic analysis of the human pituitary.","publicationDate":"2006","journal":"Pituitary","firstPage":"109","lastPage":"120","volume":"9"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219; SER-224; SER-234 AND SER-254","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"22582013","citationType":"journal article","authors":["Tagliabracci V.S.","Engel J.L.","Wen J.","Wiley S.E.","Worby C.A.","Kinch L.N.","Xiao J.","Grishin N.V.","Dixon J.E."],"citationCrossReferences":[{"database":"PubMed","id":"22582013"},{"database":"DOI","id":"10.1126/science.1217817"}],"title":"Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.","publicationDate":"2012","journal":"Science","firstPage":"1150","lastPage":"1153","volume":"336"},"referencePositions":["PHOSPHORYLATION BY FAM20C"]},{"referenceNumber":21,"citation":{"id":"23234360","citationType":"journal article","authors":["Halim A.","Ruetschi U.","Larson G.","Nilsson J."],"citationCrossReferences":[{"database":"PubMed","id":"23234360"},{"database":"DOI","id":"10.1021/pr300963h"}],"title":"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"573","lastPage":"584","volume":"12"},"referencePositions":["GLYCOSYLATION","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":22,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"26091039","citationType":"journal article","authors":["Tagliabracci V.S.","Wiley S.E.","Guo X.","Kinch L.N.","Durrant E.","Wen J.","Xiao J.","Cui J.","Nguyen K.B.","Engel J.L.","Coon J.J.","Grishin N.","Pinna L.A.","Pagliarini D.J.","Dixon J.E."],"citationCrossReferences":[{"database":"PubMed","id":"26091039"},{"database":"DOI","id":"10.1016/j.cell.2015.05.028"}],"title":"A single kinase generates the majority of the secreted phosphoproteome.","publicationDate":"2015","journal":"Cell","firstPage":"1619","lastPage":"1632","volume":"161"},"referencePositions":["PHOSPHORYLATION AT SER-26; SER-27; SER-62; SER-63; THR-190; SER-191; SER-195; SER-215; SER-219; SER-224; TYR-225; SER-228; SER-234; THR-237; SER-239; SER-243; SER-254; SER-258; SER-263; SER-267; SER-270; SER-275; SER-280; SER-291; SER-303; SER-308; SER-310 AND SER-311"]},{"referenceNumber":24,"citation":{"id":"25326458","citationType":"journal article","authors":["Noborn F.","Gomez Toledo A.","Sihlbom C.","Lengqvist J.","Fries E.","Kjellen L.","Nilsson J.","Larson G."],"citationCrossReferences":[{"database":"PubMed","id":"25326458"},{"database":"DOI","id":"10.1074/mcp.m114.043703"}],"title":"Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.","publicationDate":"2015","journal":"Mol. Cell. Proteomics","firstPage":"41","lastPage":"49","volume":"14"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY","GLYCOSYLATION AT SER-234 AND SER-308"]},{"referenceNumber":25,"citation":{"id":"36213313","citationType":"journal article","authors":["Ramarajan M.G.","Saraswat M.","Budhraja R.","Garapati K.","Raymond K.","Pandey A."],"citationCrossReferences":[{"database":"PubMed","id":"36213313"},{"database":"DOI","id":"10.1007/s42485-022-00092-3"}],"title":"Mass spectrometric analysis of chondroitin sulfate-linked peptides.","publicationDate":"2022","journal":"J. Proteins Proteom.","firstPage":"187","lastPage":"203","volume":"13"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY","GLYCOSYLATION AT SER-308"]},{"referenceNumber":26,"citation":{"id":"37453717","citationType":"journal article","authors":["Noborn F.","Nilsson J.","Sihlbom C.","Nikpour M.","Kjellen L.","Larson G."],"citationCrossReferences":[{"database":"PubMed","id":"37453717"},{"database":"DOI","id":"10.1016/j.mcpro.2023.100617"}],"title":"Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.","publicationDate":"2023","journal":"Mol. Cell. Proteomics","firstPage":"100617","lastPage":"100617","volume":"22"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY","GLYCOSYLATION AT SER-234 AND SER-308"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X13694","properties":[{"key":"ProteinId","value":"CAA31984.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"J04765","properties":[{"key":"ProteinId","value":"AAA59974.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"M83248","properties":[{"key":"ProteinId","value":"AAA17675.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U20758","properties":[{"key":"ProteinId","value":"AAA86886.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"D14813","properties":[{"key":"ProteinId","value":"BAA03554.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"D28759","properties":[{"key":"ProteinId","value":"BAA05949.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D28760","properties":[{"key":"ProteinId","value":"BAA05950.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"D28761","properties":[{"key":"ProteinId","value":"BAA05951.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF052124","properties":[{"key":"ProteinId","value":"AAC28619.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK290104","properties":[{"key":"ProteinId","value":"BAF82793.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"JF412667","properties":[{"key":"ProteinId","value":"AEA49031.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK075463","properties":[{"key":"ProteinId","value":"BAC11635.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK290090","properties":[{"key":"ProteinId","value":"BAF82779.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK296035","properties":[{"key":"ProteinId","value":"BAG58801.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK315461","properties":[{"key":"ProteinId","value":"BAG37848.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ839491","properties":[{"key":"ProteinId","value":"ABI63352.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ846871","properties":[{"key":"ProteinId","value":"ABI63358.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC131944","properties":[{"key":"ProteinId","value":"AAY41035.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471057","properties":[{"key":"ProteinId","value":"EAX06004.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471057","properties":[{"key":"ProteinId","value":"EAX06005.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471057","properties":[{"key":"ProteinId","value":"EAX06006.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC007016","properties":[{"key":"ProteinId","value":"AAH07016.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC017387","properties":[{"key":"ProteinId","value":"AAH17387.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC022844","properties":[{"key":"ProteinId","value":"AAH22844.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC093033","properties":[{"key":"ProteinId","value":"AAH93033.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS34027.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P10451-3"},{"database":"CCDS","id":"CCDS3626.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P10451-5"},{"database":"CCDS","id":"CCDS43250.1","properties":[{"key":"Description","value":"-"}],"isoformId":"P10451-1"},{"database":"PIR","id":"S50028","properties":[{"key":"EntryName","value":"S09575"}]},{"database":"RefSeq","id":"NP_000573.1","properties":[{"key":"NucleotideSequenceId","value":"NM_000582.3"}],"isoformId":"P10451-5"},{"database":"RefSeq","id":"NP_001035147.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001040058.2"}],"isoformId":"P10451-1"},{"database":"RefSeq","id":"NP_001035149.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001040060.2"}],"isoformId":"P10451-3"},{"database":"RefSeq","id":"NP_001238758.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001251829.2"}]},{"database":"RefSeq","id":"NP_001238759.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001251830.2"}]},{"database":"PDB","id":"3CXD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"P=40-51"}]},{"database":"PDB","id":"3DSF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.80 A"},{"key":"Chains","value":"P=40-51"}]},{"database":"PDB","id":"9EOU","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.55 A"},{"key":"Chains","value":"P=153-168"}]},{"database":"PDBsum","id":"3CXD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3DSF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EOU","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"PCDDB","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112574","properties":[{"key":"Interactions","value":"124"}]},{"database":"CORUM","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-49933N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"P10451","properties":[{"key":"Number of interactors","value":"746"}]},{"database":"IntAct","id":"P10451","properties":[{"key":"Interactions","value":"24"}]},{"database":"MINT","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-SPP1","properties":[{"key":"Evidences","value":"26 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000378517","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1741309","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"P10451","properties":[{"key":"glycosylation","value":"2 N-Linked glycans, 1 O-Linked glycan (1 site)"}]},{"database":"GlyCosmos","id":"P10451","properties":[{"key":"glycosylation","value":"7 sites, 11 glycans"}]},{"database":"GlyGen","id":"P10451","properties":[{"key":"glycosylation","value":"11 sites, 4 N-linked glycans (1 site), 8 O-linked glycans (7 sites)"}]},{"database":"iPTMnet","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SPP1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"129260","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000378517","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"52605","properties":[{"key":"Description","value":"-"}],"isoformId":"P10451-1"},{"database":"ProteomicsDB","id":"52607","properties":[{"key":"Description","value":"-"}],"isoformId":"P10451-3"},{"database":"ProteomicsDB","id":"52608","properties":[{"key":"Description","value":"-"}],"isoformId":"P10451-4"},{"database":"ProteomicsDB","id":"52609","properties":[{"key":"Description","value":"-"}],"isoformId":"P10451-5"},{"database":"ABCD","id":"P10451","properties":[{"key":"antibodies","value":"14 sequenced antibodies"}]},{"database":"Antibodypedia","id":"3695","properties":[{"key":"antibodies","value":"1597 antibodies from 53 providers"}]},{"database":"CPTC","id":"P10451","properties":[{"key":"antibodies","value":"1 antibody"}]},{"database":"DNASU","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000237623.11","properties":[{"key":"ProteinId","value":"ENSP00000237623.7"},{"key":"GeneId","value":"ENSG00000118785.16"}],"isoformId":"P10451-5"},{"database":"Ensembl","id":"ENST00000360804.4","properties":[{"key":"ProteinId","value":"ENSP00000354042.4"},{"key":"GeneId","value":"ENSG00000118785.16"}],"isoformId":"P10451-3"},{"database":"Ensembl","id":"ENST00000395080.8","properties":[{"key":"ProteinId","value":"ENSP00000378517.3"},{"key":"GeneId","value":"ENSG00000118785.16"}],"isoformId":"P10451-1"},{"database":"Ensembl","id":"ENST00000614857.5","properties":[{"key":"ProteinId","value":"ENSP00000477824.2"},{"key":"GeneId","value":"ENSG00000118785.16"}],"isoformId":"P10451-1"},{"database":"Ensembl","id":"ENST00000882523.1","properties":[{"key":"ProteinId","value":"ENSP00000552582.1"},{"key":"GeneId","value":"ENSG00000118785.16"}],"isoformId":"P10451-1"},{"database":"Ensembl","id":"ENST00000882524.1","properties":[{"key":"ProteinId","value":"ENSP00000552583.1"},{"key":"GeneId","value":"ENSG00000118785.16"}],"isoformId":"P10451-3"},{"database":"Ensembl","id":"ENST00000942419.1","properties":[{"key":"ProteinId","value":"ENSP00000612478.1"},{"key":"GeneId","value":"ENSG00000118785.16"}],"isoformId":"P10451-1"},{"database":"Ensembl","id":"ENST00000942420.1","properties":[{"key":"ProteinId","value":"ENSP00000612479.1"},{"key":"GeneId","value":"ENSG00000118785.16"}],"isoformId":"P10451-5"},{"database":"GeneID","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6696","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000395080.8","properties":[{"key":"ProteinId","value":"ENSP00000378517.3"},{"key":"RefSeqNucleotideId","value":"NM_001040058.2"},{"key":"RefSeqProteinId","value":"NP_001035147.1"}]},{"database":"UCSC","id":"uc003hra.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"P10451-1"},{"database":"AGR","id":"HGNC:11255","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA36085","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SPP1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11255","properties":[{"key":"GeneName","value":"SPP1"}]},{"database":"HPA","id":"ENSG00000118785","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain, gallbladder, kidney, placenta)"}]},{"database":"MalaCards","id":"SPP1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"166490","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000118785","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"93552","properties":[{"key":"Disease","value":"Pediatric systemic lupus erythematosus"}]},{"database":"Orphanet","id":"536","properties":[{"key":"Disease","value":"Systemic lupus erythematosus"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000118785","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S5R4","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000002509","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_953033_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HSAEDHH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9047304at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P10451","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1474228","properties":[{"key":"PathwayName","value":"Degradation of the extracellular matrix"}]},{"database":"Reactome","id":"R-HSA-186797","properties":[{"key":"PathwayName","value":"Signaling by PDGF"}]},{"database":"Reactome","id":"R-HSA-216083","properties":[{"key":"PathwayName","value":"Integrin cell surface interactions"}]},{"database":"Reactome","id":"R-HSA-381426","properties":[{"key":"PathwayName","value":"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"}]},{"database":"Reactome","id":"R-HSA-8949275","properties":[{"key":"PathwayName","value":"RUNX3 Regulates Immune Response and Cell Migration"}]},{"database":"Reactome","id":"R-HSA-8957275","properties":[{"key":"PathwayName","value":"Post-translational protein phosphorylation"}]},{"database":"Reactome","id":"R-HSA-9856532","properties":[{"key":"PathwayName","value":"Mechanical load activates signaling by PIEZO1 and integrins in osteocytes"}]},{"database":"SignaLink","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000118785","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6696","properties":[{"key":"hits","value":"13 hits in 1150 CRISPR screens"}]},{"database":"ChiTaRS","id":"SPP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P10451","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"Osteopontin","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P10451","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P10451","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"P10451","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000118785","properties":[{"key":"ExpressionPatterns","value":"Expressed in gall bladder and 181 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P10451","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0045177","properties":[{"key":"GoTerm","value":"C:apical part of cell"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005788","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum lumen"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15516325"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IPI:DisProt"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24928493"}]},{"database":"GO","id":"GO:0050840","properties":[{"key":"GoTerm","value":"F:extracellular matrix binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005178","properties":[{"key":"GoTerm","value":"F:integrin binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25839998"}]},{"database":"GO","id":"GO:0036094","properties":[{"key":"GoTerm","value":"F:small molecule binding"},{"key":"GoEvidenceType","value":"EXP:DisProt"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33914399"}]},{"database":"GO","id":"GO:0006710","properties":[{"key":"GoTerm","value":"P:androgen catabolic process"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26482249"}]},{"database":"GO","id":"GO:0030282","properties":[{"key":"GoTerm","value":"P:bone mineralization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0055074","properties":[{"key":"GoTerm","value":"P:calcium ion homeostasis"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"IDA:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25839998"}]},{"database":"GO","id":"GO:0071394","properties":[{"key":"GoTerm","value":"P:cellular response to testosterone stimulus"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26482249"}]},{"database":"GO","id":"GO:0046697","properties":[{"key":"GoTerm","value":"P:decidualization"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16720713"}]},{"database":"GO","id":"GO:0007566","properties":[{"key":"GoTerm","value":"P:embryo implantation"},{"key":"GoEvidenceType","value":"TAS:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"16720713"}]},{"database":"GO","id":"GO:0048685","properties":[{"key":"GoTerm","value":"P:negative regulation of collateral sprouting of intact axon in response to injury"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001649","properties":[{"key":"GoTerm","value":"P:osteoblast differentiation"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045780","properties":[{"key":"GoTerm","value":"P:positive regulation of bone resorption"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26482249"}]},{"database":"GO","id":"GO:2000866","properties":[{"key":"GoTerm","value":"P:positive regulation of estradiol secretion"},{"key":"GoEvidenceType","value":"IDA:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26482249"}]},{"database":"GO","id":"GO:1904612","properties":[{"key":"GoTerm","value":"P:response to 2,3,7,8-tetrachlorodibenzodioxine"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0036005","properties":[{"key":"GoTerm","value":"P:response to macrophage colony-stimulating factor"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0048545","properties":[{"key":"GoTerm","value":"P:response to steroid hormone"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0033280","properties":[{"key":"GoTerm","value":"P:response to vitamin D"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16720713"}]},{"database":"DisProt","id":"DP00214","properties":[{"key":"Description","value":"-"}]},{"database":"IDEAL","id":"IID00649","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR002038","properties":[{"key":"EntryName","value":"Osteopontin"}]},{"database":"InterPro","id":"IPR019841","properties":[{"key":"EntryName","value":"Osteopontin_CS"}]},{"database":"PANTHER","id":"PTHR10607","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10607:SF1","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00865","properties":[{"key":"EntryName","value":"Osteopontin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00216","properties":[{"key":"EntryName","value":"OSTEOPONTIN"}]},{"database":"SMART","id":"SM00017","properties":[{"key":"EntryName","value":"OSTEO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00884","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN","length":314,"molWeight":35423,"crc64":"4996429EC4752B86","md5":"F4F0850CC52ADE2D97CE08D064951EE6"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"INTERACTION":8,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"TISSUE SPECIFICITY":1,"PTM":3,"SIMILARITY":1,"WEB RESOURCE":2},"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Motif":1,"Compositional bias":6,"Modified residue":43,"Glycosylation":7,"Alternative sequence":3,"Natural variant":2,"Sequence conflict":3,"Beta strand":1},"uniParcId":"UPI0000000E0B"}},{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9BX95","secondaryAccessions":["B2RAH0","Q9H189"],"uniProtkbId":"SGPP1_HUMAN","entryAudit":{"firstPublicDate":"2003-10-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-04-26","entryVersion":172,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Sphingosine-1-phosphate phosphatase 1"},"shortNames":[{"value":"SPPase1"},{"value":"Spp1"},{"value":"hSPP1"},{"value":"hSPPase1"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16782891"}],"value":"3.1.3.-"}]},"alternativeNames":[{"fullName":{"value":"Sphingosine-1-phosphatase 1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16782891"}],"value":"Sphingosine-1-phosphate phosphohydrolase 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16782891"}],"value":"SPP-1"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:17720"}],"value":"SGPP1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16782891"}],"value":"SPP1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JI99"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11756451"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16782891"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18583713"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20798685"}],"value":"Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:11756451, PubMed:12815058, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:11756451, PubMed:12815058, PubMed:16782891). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide through a phosphorylation/dephosphorylation cycle (By similarity). Regulates endoplasmic-to-Golgi trafficking of ceramides, resulting in the regulation of ceramide levels in the endoplasmic reticulum, preferentially long-chain ceramide species, and influences the anterograde membrane transport of both ceramide and proteins from the endoplasmic reticulum to the Golgi apparatus (PubMed:16782891). The modulation of intracellular ceramide levels in turn regulates apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:18583713, PubMed:20798685). Involved in the regulation of epidermal homeostasis and keratinocyte differentiation (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"sphinganine 1-phosphate + H2O = sphinganine + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:27514"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57817"},{"database":"ChEBI","id":"CHEBI:57939"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:27515"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:27518"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57756"},{"database":"ChEBI","id":"CHEBI:60119"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16782891"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:27519"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16782891"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JI99"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"}],"value":"Ubiquitous, with the strongest level in placenta and kidney"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the type 2 lipid phosphate phosphatase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Sphingosine-1-phosphate phosphatase 1","featureId":"PRO_0000114477"},{"type":"Transmembrane","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":310,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Phosphatase sequence motif I","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"Phosphatase sequence motif II","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Phosphatase sequence motif III","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Compositional bias","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Active site","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0A924"}]},{"type":"Active site","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0A924"}]},{"type":"Site","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Stabilizes the active site histidine for nucleophilic attack","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P0A924"}]},{"type":"Modified residue","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Mutagenesis","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"Abolishes phosphatase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18583713"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"in Ref. 1; AAK26660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"in Ref. 1; AAK26660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in Ref. 1; AAK26660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"in Ref. 1; AAK26660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"in Ref. 1; AAK26660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"in Ref. 1; AAK26660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":410,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"in Ref. 1; AAK26660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"12815058","citationType":"journal article","authors":["Johnson K.R.","Johnson K.Y.","Becker K.P.","Bielawski J.","Mao C.","Obeid L.M."],"citationCrossReferences":[{"database":"PubMed","id":"12815058"},{"database":"DOI","id":"10.1074/jbc.m301741200"}],"title":"Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"34541","lastPage":"34547","volume":"278"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY","SUBCELLULAR LOCATION","FUNCTION","CATALYTIC ACTIVITY"],"referenceComments":[{"value":"Fetal kidney","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-9QQAB9IGHC57B","citationType":"submission","authors":["Van Veldhoven P.P."],"title":"Cloning of human sphingosine-1-phosphatase.","publicationDate":"SEP-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Thalamus","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"12508121","citationType":"journal article","authors":["Heilig R.","Eckenberg R.","Petit J.-L.","Fonknechten N.","Da Silva C.","Cattolico L.","Levy M.","Barbe V.","De Berardinis V.","Ureta-Vidal A.","Pelletier E.","Vico V.","Anthouard V.","Rowen L.","Madan A.","Qin S.","Sun H.","Du H.","Pepin K.","Artiguenave F.","Robert C.","Cruaud C.","Bruels T.","Jaillon O.","Friedlander L.","Samson G.","Brottier P.","Cure S.","Segurens B.","Aniere F.","Samain S.","Crespeau H.","Abbasi N.","Aiach N.","Boscus D.","Dickhoff R.","Dors M.","Dubois I.","Friedman C.","Gouyvenoux M.","James R.","Madan A.","Mairey-Estrada B.","Mangenot S.","Martins N.","Menard M.","Oztas S.","Ratcliffe A.","Shaffer T.","Trask B.","Vacherie B.","Bellemere C.","Belser C.","Besnard-Gonnet M.","Bartol-Mavel D.","Boutard M.","Briez-Silla S.","Combette S.","Dufosse-Laurent V.","Ferron C.","Lechaplais C.","Louesse C.","Muselet D.","Magdelenat G.","Pateau E.","Petit E.","Sirvain-Trukniewicz P.","Trybou A.","Vega-Czarny N.","Bataille E.","Bluet E.","Bordelais I.","Dubois M.","Dumont C.","Guerin T.","Haffray S.","Hammadi R.","Muanga J.","Pellouin V.","Robert D.","Wunderle E.","Gauguet G.","Roy A.","Sainte-Marthe L.","Verdier J.","Verdier-Discala C.","Hillier L.W.","Fulton L.","McPherson J.","Matsuda F.","Wilson R.","Scarpelli C.","Gyapay G.","Wincker P.","Saurin W.","Quetier F.","Waterston R.","Hood L.","Weissenbach J."],"citationCrossReferences":[{"database":"PubMed","id":"12508121"},{"database":"DOI","id":"10.1038/nature01348"}],"title":"The DNA sequence and analysis of human chromosome 14.","publicationDate":"2003","journal":"Nature","firstPage":"601","lastPage":"607","volume":"421"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"},{"value":"PNS","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"11756451","citationType":"journal article","authors":["Le Stunff H.","Peterson C.","Thornton R.","Milstien S.","Mandala S.M.","Spiegel S."],"citationCrossReferences":[{"database":"PubMed","id":"11756451"},{"database":"DOI","id":"10.1074/jbc.m109968200"}],"title":"Characterization of murine sphingosine-1-phosphate phosphohydrolase.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"8920","lastPage":"8927","volume":"277"},"referencePositions":["FUNCTION"]},{"referenceNumber":8,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"16782891","citationType":"journal article","authors":["Giussani P.","Maceyka M.","Le Stunff H.","Mikami A.","Lepine S.","Wang E.","Kelly S.","Merrill A.H. Jr.","Milstien S.","Spiegel S."],"citationCrossReferences":[{"database":"PubMed","id":"16782891"},{"database":"DOI","id":"10.1128/mcb.02107-05"}],"title":"Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.","publicationDate":"2006","journal":"Mol. Cell. Biol.","firstPage":"5055","lastPage":"5069","volume":"26"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":10,"citation":{"id":"18583713","citationType":"journal article","authors":["Peter B.F.","Lidington D.","Harada A.","Bolz H.J.","Vogel L.","Heximer S.","Spiegel S.","Pohl U.","Bolz S.S."],"citationCrossReferences":[{"database":"PubMed","id":"18583713"},{"database":"DOI","id":"10.1161/circresaha.108.173575"}],"title":"Role of sphingosine-1-phosphate phosphohydrolase 1 in the regulation of resistance artery tone.","publicationDate":"2008","journal":"Circ. Res.","firstPage":"315","lastPage":"324","volume":"103"},"referencePositions":["FUNCTION","MUTAGENESIS OF HIS-208"]},{"referenceNumber":11,"citation":{"id":"18220336","citationType":"journal article","authors":["Cantin G.T.","Yi W.","Lu B.","Park S.K.","Xu T.","Lee J.-D.","Yates J.R. III"],"citationCrossReferences":[{"database":"PubMed","id":"18220336"},{"database":"DOI","id":"10.1021/pr0705441"}],"title":"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"1346","lastPage":"1351","volume":"7"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112 AND THR-114","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"19369195","citationType":"journal article","authors":["Oppermann F.S.","Gnad F.","Olsen J.V.","Hornberger R.","Greff Z.","Keri G.","Mann M.","Daub H."],"citationCrossReferences":[{"database":"PubMed","id":"19369195"},{"database":"DOI","id":"10.1074/mcp.m800588-mcp200"}],"title":"Large-scale proteomics analysis of the human kinome.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"1751","lastPage":"1764","volume":"8"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101 AND SER-112","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"20798685","citationType":"journal article","authors":["Lepine S.","Allegood J.C.","Park M.","Dent P.","Milstien S.","Spiegel S."],"citationCrossReferences":[{"database":"PubMed","id":"20798685"},{"database":"DOI","id":"10.1038/cdd.2010.104"}],"title":"Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.","publicationDate":"2011","journal":"Cell Death Differ.","firstPage":"350","lastPage":"361","volume":"18"},"referencePositions":["FUNCTION"]},{"referenceNumber":17,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101 AND SER-112","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF349315","properties":[{"key":"ProteinId","value":"AAK26660.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ293294","properties":[{"key":"ProteinId","value":"CAC17772.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK314188","properties":[{"key":"ProteinId","value":"BAG36867.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL161670","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471061","properties":[{"key":"ProteinId","value":"EAW80834.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC063839","properties":[{"key":"ProteinId","value":"AAH63839.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC070060","properties":[{"key":"ProteinId","value":"AAH70060.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS9760.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_110418.1","properties":[{"key":"NucleotideSequenceId","value":"NM_030791.4"}]},{"database":"AlphaFoldDB","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"123508","properties":[{"key":"Interactions","value":"56"}]},{"database":"FunCoup","id":"Q9BX95","properties":[{"key":"Number of interactors","value":"1105"}]},{"database":"IntAct","id":"Q9BX95","properties":[{"key":"Interactions","value":"46"}]},{"database":"NDEx","id":"IQUERY-CP-SGPP1","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000247225","properties":[{"key":"Description","value":"-"}]},{"database":"SwissLipids","id":"SLP:000000158","properties":[{"key":"Description","value":"-"}]},{"database":"DEPOD","id":"SGPP1","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9BX95","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SGPP1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"46577706","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000247225","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"79388","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"47291","properties":[{"key":"antibodies","value":"90 antibodies from 19 providers"}]},{"database":"DNASU","id":"81537","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000247225.7","properties":[{"key":"ProteinId","value":"ENSP00000247225.6"},{"key":"GeneId","value":"ENSG00000126821.9"}]},{"database":"Ensembl","id":"ENST00000645915.2","properties":[{"key":"ProteinId","value":"ENSP00000496280.1"},{"key":"GeneId","value":"ENSG00000285281.2"}]},{"database":"GeneID","id":"81537","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:81537","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000247225.7","properties":[{"key":"ProteinId","value":"ENSP00000247225.6"},{"key":"RefSeqNucleotideId","value":"NM_030791.4"},{"key":"RefSeqProteinId","value":"NP_110418.1"}]},{"database":"UCSC","id":"uc001xgj.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:17720","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134884424","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"81537","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"81537","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SGPP1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:17720","properties":[{"key":"GeneName","value":"SGPP1"}]},{"database":"HPA","id":"ENSG00000126821","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"612826","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000126821","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000126821","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2822","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158836","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_043042_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GRWEYPY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"301434at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9BX95","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9845614","properties":[{"key":"PathwayName","value":"Sphingolipid catabolism"}]},{"database":"SignaLink","id":"Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000126821","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"81537","properties":[{"key":"hits","value":"108 hits in 1172 CRISPR screens"}]},{"database":"ChiTaRS","id":"SGPP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"SGPP1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"81537","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9BX95","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9BX95","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"RNAct","id":"Q9BX95","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000126821","properties":[{"key":"ExpressionPatterns","value":"Expressed in lymph node and 101 other cell types or tissues"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070780","properties":[{"key":"GoTerm","value":"F:dihydrosphingosine-1-phosphate phosphatase activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12815058"}]},{"database":"GO","id":"GO:0042392","properties":[{"key":"GoTerm","value":"F:sphingosine-1-phosphate phosphatase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16782891"}]},{"database":"GO","id":"GO:0035621","properties":[{"key":"GoTerm","value":"P:ER to Golgi ceramide transport"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16782891"}]},{"database":"GO","id":"GO:0046839","properties":[{"key":"GoTerm","value":"P:phospholipid dephosphorylation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0045682","properties":[{"key":"GoTerm","value":"P:regulation of epidermis development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045616","properties":[{"key":"GoTerm","value":"P:regulation of keratinocyte differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030149","properties":[{"key":"GoTerm","value":"P:sphingolipid catabolic process"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0006670","properties":[{"key":"GoTerm","value":"P:sphingosine metabolic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd03388","properties":[{"key":"EntryName","value":"PAP2_SPPase1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.144.10:FF:000011","properties":[{"key":"EntryName","value":"sphingosine-1-phosphate phosphatase 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.144.10","properties":[{"key":"EntryName","value":"Phosphatidic acid phosphatase type 2/haloperoxidase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000326","properties":[{"key":"EntryName","value":"PAP2/HPO"}]},{"database":"InterPro","id":"IPR036938","properties":[{"key":"EntryName","value":"PAP2/HPO_sf"}]},{"database":"PANTHER","id":"PTHR14969:SF45","properties":[{"key":"EntryName","value":"SPHINGOSINE-1-PHOSPHATE PHOSPHATASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14969","properties":[{"key":"EntryName","value":"SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01569","properties":[{"key":"EntryName","value":"PAP2"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00014","properties":[{"key":"EntryName","value":"acidPPc"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48317","properties":[{"key":"EntryName","value":"Acid phosphatase/Vanadium-dependent haloperoxidase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSLRQRLAQLVGRLQDPQKVARFQRLCGVEAPPRRSADRREDEKAEAPLAGDPRLRGRQPGAPGGPQPPGSDRNQCPAKPDGGGAPNGVRNGLAAELGPASPRRAGALRRNSLTGEEGQLARVSNWPLYCLFCFGTELGNELFYILFFPFWIWNLDPLVGRRLVVIWVLVMYLGQCTKDIIRWPRPASPPVVKLEVFYNSEYSMPSTHAMSGTAIPISMVLLTYGRWQYPLIYGLILIPCWCSLVCLSRIYMGMHSILDIIAGFLYTILILAVFYPFVDLIDNFNQTHKYAPFIIIGLHLALGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHVTYNMGLVLDPSLDTLPLAGPPITVTLFGKAILRILIGMVFVLIIRDVMKKITIPLACKIFNIPCDDIRKARQHMEVELPYRYITYGMVGFSITFFVPYIFFFIGIS","length":441,"molWeight":49108,"crc64":"86A018DDDA3A3019","md5":"F84BC6A5FFB437B014456131C75DBC65"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":9,"Region":4,"Compositional bias":1,"Active site":2,"Site":1,"Modified residue":3,"Mutagenesis":1,"Sequence conflict":7},"uniParcId":"UPI000006DEB2"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A804HLB3","uniProtkbId":"A0A804HLB3_HUMAN","entryAudit":{"firstPublicDate":"2021-09-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2021-09-29","entryVersion":23,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000508280.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000508280.1"}],"value":"Secreted phosphoprotein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000508280.1"}],"value":"SPP1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007517"}],"value":"Belongs to the osteopontin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5032450692"},{"type":"Region","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":104,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A804HLB3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A804HLB3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022981"}],"id":"KW-0730","category":"Ligand","name":"Sialic acid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000508280.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000508280.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000508280.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000508280.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC131944","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"A0A804HLB3","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000682655.1","properties":[{"key":"ProteinId","value":"ENSP00000508280.1"},{"key":"GeneId","value":"ENSG00000118785.16"}]},{"database":"HGNC","id":"HGNC:11255","properties":[{"key":"GeneName","value":"SPP1"}]},{"database":"GeneTree","id":"ENSGT00390000002509","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9047304at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"Bgee","id":"ENSG00000118785","properties":[{"key":"ExpressionPatterns","value":"Expressed in gall bladder and 181 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"A0A804HLB3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0001503","properties":[{"key":"GoTerm","value":"P:ossification"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR002038","properties":[{"key":"EntryName","value":"Osteopontin"}]},{"database":"InterPro","id":"IPR019841","properties":[{"key":"EntryName","value":"Osteopontin_CS"}]},{"database":"PANTHER","id":"PTHR10607","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10607:SF1","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00865","properties":[{"key":"EntryName","value":"Osteopontin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00216","properties":[{"key":"EntryName","value":"OSTEOPONTIN"}]},{"database":"SMART","id":"SM00017","properties":[{"key":"EntryName","value":"OSTEO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00884","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQVNPLTDTPDGSD","length":192,"molWeight":21283,"crc64":"F52014DFE5622F45","md5":"7D483066043DD41032CE2ED6FE3D9BE4"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":2,"Compositional bias":5},"uniParcId":"UPI0000E09043"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8S0K2","uniProtkbId":"A0ACI8S0K2_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552581.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552581.1"}],"value":"Secreted phosphoprotein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552581.1"}],"value":"SPP1"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051262521"},{"type":"Region","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8S0K2"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8S0K2"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552581.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552581.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552581.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552581.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC131944","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000882522.1","properties":[{"key":"ProteinId","value":"ENSP00000552581.1"},{"key":"GeneId","value":"ENSG00000118785.16"}]},{"database":"HGNC","id":"HGNC:11255","properties":[{"key":"GeneName","value":"SPP1"}]},{"database":"OpenTargets","id":"ENSG00000118785","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000002509","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"InterPro","id":"IPR002038","properties":[{"key":"EntryName","value":"Osteopontin"}]},{"database":"PANTHER","id":"PTHR10607","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10607:SF1","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00865","properties":[{"key":"EntryName","value":"Osteopontin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00216","properties":[{"key":"EntryName","value":"OSTEOPONTIN"}]},{"database":"SMART","id":"SM00017","properties":[{"key":"EntryName","value":"OSTEO"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRIAVICFCLLGITCAIPADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN","length":311,"molWeight":35067,"crc64":"6A9CCF08BE14E3A7","md5":"53ED42605432A20D9E017B040A515B2C"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Compositional bias":6},"uniParcId":"UPI004031E87C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T0T1","uniProtkbId":"A0ACI8T0T1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590489.1"}],"value":"Secreted phosphoprotein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590489.1"}],"value":"SPP1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007517"}],"value":"Belongs to the osteopontin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051319355"},{"type":"Region","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":85,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T0T1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T0T1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022981"}],"id":"KW-0730","category":"Ligand","name":"Sialic acid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000590489.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC131944","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000920430.1","properties":[{"key":"ProteinId","value":"ENSP00000590489.1"},{"key":"GeneId","value":"ENSG00000118785.16"}]},{"database":"HGNC","id":"HGNC:11255","properties":[{"key":"GeneName","value":"SPP1"}]},{"database":"OpenTargets","id":"ENSG00000118785","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000002509","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"InterPro","id":"IPR002038","properties":[{"key":"EntryName","value":"Osteopontin"}]},{"database":"InterPro","id":"IPR019841","properties":[{"key":"EntryName","value":"Osteopontin_CS"}]},{"database":"PANTHER","id":"PTHR10607","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10607:SF1","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00865","properties":[{"key":"EntryName","value":"Osteopontin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00216","properties":[{"key":"EntryName","value":"OSTEOPONTIN"}]},{"database":"SMART","id":"SM00017","properties":[{"key":"EntryName","value":"OSTEO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00884","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRIAVICFCLLGITCAIPVKQADSGSSEEKQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN","length":295,"molWeight":33248,"crc64":"12F09DBF23BBEB91","md5":"603073F364C66B6E2132021CF8CDE02E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Compositional bias":6},"uniParcId":"UPI004031AB59"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8RQ61","uniProtkbId":"A0ACI8RQ61_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552584.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552584.1"}],"value":"Secreted phosphoprotein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552584.1"}],"value":"SPP1"}}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051370271"},{"type":"Region","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":79,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":251,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8RQ61"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8RQ61"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552584.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552584.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552584.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000552584.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC131944","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000882525.1","properties":[{"key":"ProteinId","value":"ENSP00000552584.1"},{"key":"GeneId","value":"ENSG00000118785.16"}]},{"database":"HGNC","id":"HGNC:11255","properties":[{"key":"GeneName","value":"SPP1"}]},{"database":"OpenTargets","id":"ENSG00000118785","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000002509","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"InterPro","id":"IPR002038","properties":[{"key":"EntryName","value":"Osteopontin"}]},{"database":"PANTHER","id":"PTHR10607","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10607:SF1","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00865","properties":[{"key":"EntryName","value":"Osteopontin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00216","properties":[{"key":"EntryName","value":"OSTEOPONTIN"}]},{"database":"SMART","id":"SM00017","properties":[{"key":"EntryName","value":"OSTEO"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRIAVICFCLLGITCAIPADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQTLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN","length":297,"molWeight":33488,"crc64":"CEA6B73556CB53C3","md5":"94BF7DBD166DE6E57EEC206BFDECF465"},"extraAttributes":{"countByFeatureType":{"Signal":1,"Chain":1,"Region":2,"Compositional bias":6},"uniParcId":"UPI0040319159"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"B7Z351","uniProtkbId":"B7Z351_HUMAN","entryAudit":{"firstPublicDate":"2009-03-03","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2009-03-03","entryVersion":64,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAH12087.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALE30613.1"}],"value":"Secreted phosphoprotein 1 variant 6"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAH12087.1"}],"value":"cDNA FLJ54682, highly similar to Osteopontin"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALE30613.1"}],"value":"SPP1"}}],"features":[{"type":"Region","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":303,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2ELFNBL2J9UAG","citationType":"submission","authors":["Wakamatsu A.","Yamamoto J.","Kimura K.","Ishii S.","Watanabe K.","Sugiyama A.","Murakawa K.","Kaida T.","Tsuchiya K.","Fukuzumi Y.","Kumagai A.","Oishi Y.","Yamamoto S.","Ono Y.","Komori Y.","Yamazaki M.","Kisu Y.","Nishikawa T.","Sugano S.","Nomura N.","Isogai T."],"title":"NEDO human cDNA sequencing project focused on splicing variants.","publicationDate":"OCT-2007","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAH12087.1"}],"value":"Hippocampus","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"BAH12087.1"}]},{"referenceNumber":2,"citation":{"id":"CI-14A4MVEFJUDJG","citationType":"submission","authors":["Mehravar M.","Poursani E.M."],"title":"Identification of new alternative polyadenylation variant of SPP1 gene in U87-MG cell line.","publicationDate":"APR-2015","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"ALE30613.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"KR062183","properties":[{"key":"ProteinId","value":"ALE30613.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK295491","properties":[{"key":"ProteinId","value":"BAH12087.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001238759.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001251830.2"}]},{"database":"AlphaFoldDB","id":"B7Z351","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9047304at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"6696","properties":[{"key":"hits","value":"13 hits in 1150 CRISPR screens"}]},{"database":"ChiTaRS","id":"SPP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0007155","properties":[{"key":"GoTerm","value":"P:cell adhesion"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0001503","properties":[{"key":"GoTerm","value":"P:ossification"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR002038","properties":[{"key":"EntryName","value":"Osteopontin"}]},{"database":"PANTHER","id":"PTHR10607","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10607:SF1","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00865","properties":[{"key":"EntryName","value":"Osteopontin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00216","properties":[{"key":"EntryName","value":"OSTEOPONTIN"}]},{"database":"SMART","id":"SM00017","properties":[{"key":"EntryName","value":"OSTEO"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGIVPRSLDKKAHRVQFQLNRIKAKIELPWGSLQLDCLMKTLKELYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN","length":327,"molWeight":37245,"crc64":"D90C8AB78360F1B9","md5":"0C25BFF54AD418F5417BA6132D69A7C4"},"extraAttributes":{"countByFeatureType":{"Region":1,"Compositional bias":6},"uniParcId":"UPI000020B17E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACM8Q8Q9","uniProtkbId":"A0ACM8Q8Q9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000422973.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000422973.2"}],"value":"Secreted phosphoprotein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000422973.2"}],"value":"SPP1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004613"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007517"}],"value":"Belongs to the osteopontin family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}]},{"type":"Chain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"featureId":"PRO_5051192068"},{"type":"Region","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022889"}],"id":"KW-0130","category":"Biological process","name":"Cell adhesion"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022553"}],"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACM8Q8Q9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACM8Q8Q9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022525"}],"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022981"}],"id":"KW-0730","category":"Ligand","name":"Sialic acid"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022729"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"SignalP"}],"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000422973.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000422973.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000422973.2"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"16807684","citationType":"journal article","authors":["Beranova-Giorgianni S.","Zhao Y.","Desiderio D.M.","Giorgianni F."],"citationCrossReferences":[{"database":"PubMed","id":"16807684"},{"database":"DOI","id":"10.1007/s11102-006-8916-x"}],"title":"Phosphoproteomic analysis of the human pituitary.","publicationDate":"2006","journal":"Pituitary","firstPage":"109","lastPage":"120","volume":"9"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"16807684"}]},{"referenceNumber":5,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21406692"}]},{"referenceNumber":6,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"24275569"}]},{"referenceNumber":7,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000422973.2"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC131944","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001238758.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001251829.2"}]},{"database":"DNASU","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000508233.6","properties":[{"key":"ProteinId","value":"ENSP00000422973.2"},{"key":"GeneId","value":"ENSG00000118785.16"}]},{"database":"GeneID","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6696","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11255","properties":[{"key":"GeneName","value":"SPP1"}]},{"database":"OpenTargets","id":"ENSG00000118785","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000118785","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000002509","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9047304at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"6696","properties":[{"key":"hits","value":"13 hits in 1150 CRISPR screens"}]},{"database":"ChiTaRS","id":"SPP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"Bgee","id":"ENSG00000118785","properties":[{"key":"ExpressionPatterns","value":"Expressed in gall bladder and 181 other cell types or tissues"}]},{"database":"InterPro","id":"IPR002038","properties":[{"key":"EntryName","value":"Osteopontin"}]},{"database":"InterPro","id":"IPR019841","properties":[{"key":"EntryName","value":"Osteopontin_CS"}]},{"database":"PANTHER","id":"PTHR10607","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10607:SF1","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00865","properties":[{"key":"EntryName","value":"Osteopontin"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00216","properties":[{"key":"EntryName","value":"OSTEOPONTIN"}]},{"database":"SMART","id":"SM00017","properties":[{"key":"EntryName","value":"OSTEO"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00884","properties":[{"key":"EntryName","value":"OSTEOPONTIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRIAVICFCLLGITCAIPVKQADSGSSEEKQTLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN","length":273,"molWeight":30776,"crc64":"60731AB3E45328A2","md5":"4106F060F40A9248949B4E77A048AC29"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":2,"Compositional bias":4},"uniParcId":"UPI00005C1F15"}}]}