{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P17947","uniProtkbId":"SPI1_HUMAN","entryAudit":{"firstPublicDate":"1990-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-02-01","entryVersion":224,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"33951726"}],"value":"Transcription factor PU.1"}},"alternativeNames":[{"fullName":{"value":"31 kDa-transforming protein"}}]},"genes":[{"geneName":{"value":"SPI1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P17433"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6BDS1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23658224"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33951726"}],"value":"Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P17433"}],"value":"Transcriptional activity at macrophage-specific genes is inhibited by interaction with GFI1, which results in the inhibition of SPI1-induced macrophage differentiation of myeloid progenitor cells, but not that of the granulocyte lineage"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P17433"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10196196"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10207087"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17197705"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26019275"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33951726"}],"value":"Binds DNA as a monomer. Can form homomers (PubMed:10196196). Directly interacts with CEBPD/NF-IL6-beta; this interaction does not affect DNA-binding properties of each partner (By similarity). Interacts with NONO/p54(nrb) (By similarity). Interacts with RUNX1/AML1 (PubMed:10207087). Interacts with GFI1; the interaction represses SPI1 transcriptional activity, hence blocks SPI1-induced macrophage differentiation of myeloid progenitor cells (PubMed:17197705). Interacts with CEBPE (PubMed:26019275). Interacts with IRF4/Pip and IRF8 (PubMed:10196196, PubMed:33951726). Interacts with JUN (PubMed:10196196). Interacts with RB1 (PubMed:10196196). 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