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Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Interacts with SOX2 and FGFR1"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P41225","intActId":"EBI-9078386"},"interactantTwo":{"uniProtKBAccession":"P54253","geneName":"ATXN1","intActId":"EBI-930964"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P41225","intActId":"EBI-9078386"},"interactantTwo":{"uniProtKBAccession":"O43186","geneName":"CRX","intActId":"EBI-748171"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P41225","intActId":"EBI-9078386"},"interactantTwo":{"uniProtKBAccession":"Q12933","geneName":"TRAF2","intActId":"EBI-355744"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34342803"}],"value":"The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Panhypopituitarism X-linked","diseaseAccession":"DI-02125","acronym":"PHPX","description":"Affected individuals have absent infundibulum, anterior pituitary hypoplasia, and ectopic posterior pituitary.","diseaseCrossReference":{"database":"MIM","id":"312000"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800844"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Intellectual developmental disorder, X-linked, with isolated growth hormone deficiency","diseaseAccession":"DI-01968","acronym":"MRXGH","description":"A disorder characterized by the association of variable degrees of intellectual disability with panhypopituitarism, variable combinations of hypothyroidism, delayed pubertal development, and short stature due to growth hormone deficiency.","diseaseCrossReference":{"database":"MIM","id":"300123"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12428212"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"46,XX sex reversal 3","diseaseAccession":"DI-03008","acronym":"SRXX3","description":"A condition in which male gonads develop in a genetic female (female to male sex reversal).","diseaseCrossReference":{"database":"MIM","id":"300833"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21183788"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry. 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