{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P35716","secondaryAccessions":["Q4ZFV8"],"uniProtkbId":"SOX11_HUMAN","entryAudit":{"firstPublicDate":"1994-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-02-01","entryVersion":196,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transcription factor SOX-11"}}},"genes":[{"geneName":{"value":"SOX11"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7M6Y2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24886874"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26543203"}],"value":"Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity). Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity). Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00267"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24886874"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35938035"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24886874"}],"value":"Expressed primarily in the brain and heart, with low expression in the kidney, pancreas and muscle"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24886874"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8666406"}],"value":"Expressed primarily in the fetal brain, with low expression in the lung, and kidney at 6-7 weeks dpc (PubMed:24886874, PubMed:8666406). Weak expression in the fetal heart and muscle (PubMed:24886874)"}],"commentType":"DEVELOPMENTAL STAGE"},{"commentType":"DISEASE","disease":{"diseaseId":"Intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism","diseaseAccession":"DI-04132","acronym":"IDDMOH","description":"An autosomal dominant disorder characterized by developmental delay, impaired intellectual development and microcephaly. Affected individuals may also have oculomotor apraxia, ocular malformations including coloboma, lens abnormalities and microphthalmia, and hypogonadotropic hypogonadism. Some patients may have finger clinodactyly and hypoplastic distal phalanges with nail hypoplasia, especially of the fifth digits.","diseaseCrossReference":{"database":"MIM","id":"615866"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24886874"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26543203"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28787104"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33086258"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33785884"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35642566"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35938035"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/42357/SOX11","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Transcription factor SOX-11","featureId":"PRO_0000048750"},{"type":"DNA binding","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"HMG box","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00267"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":292,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7M6Y2"}]},{"type":"Compositional bias","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Natural variant","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26543203"}],"featureId":"VAR_088026","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"in IDDMOH; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33785884"}],"featureId":"VAR_088027","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"in IDDMOH; uncertain significance; dbSNP:rs2103276319","featureCrossReferences":[{"database":"dbSNP","id":"rs2103276319"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088028","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33086258"}],"featureId":"VAR_088029","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"in IDDMOH; decreased function in positive regulation of DNA-templated transcription; compared to the wild-type, the mutant induces a severely reduced GDF5 promoter activation using an in vitro reporter system","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26543203"}],"featureId":"VAR_088030","alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088031","alternativeSequence":{"originalSequence":"K","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088032","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088033","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"in IDDMOH; dbSNP:rs2103276330","featureCrossReferences":[{"database":"dbSNP","id":"rs2103276330"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088034","alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Natural variant","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"in IDDMOH; dbSNP:rs2103276324","featureCrossReferences":[{"database":"dbSNP","id":"rs2103276324"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088035","alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Natural variant","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088036","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088037","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088038","alternativeSequence":{"originalSequence":"M","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088039","alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088040","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"in IDDMOH; dbSNP:rs2103276338","featureCrossReferences":[{"database":"dbSNP","id":"rs2103276338"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088041","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":57,"modifier":"EXACT"}},"description":"in IDDMOH; dbSNP:rs2103276340","featureCrossReferences":[{"database":"dbSNP","id":"rs2103276340"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088042","alternativeSequence":{"originalSequence":"M","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088043","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"in IDDMOH; decreases transcriptional activity; dbSNP:rs587777480","featureCrossReferences":[{"database":"dbSNP","id":"rs587777480"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24886874"}],"featureId":"VAR_071461","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088044","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088045","alternativeSequence":{"originalSequence":"R","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088046","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088047","alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088048","alternativeSequence":{"originalSequence":"H","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"in IDDMOH; dbSNP:rs1665660543","featureCrossReferences":[{"database":"dbSNP","id":"rs1665660543"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35642566"}],"featureId":"VAR_088049","alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088050","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088051","alternativeSequence":{"originalSequence":"W","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"in IDDMOH; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088052","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"in IDDMOH; dbSNP:rs1064794628","featureCrossReferences":[{"database":"dbSNP","id":"rs1064794628"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35642566"}],"featureId":"VAR_088053","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"in IDDMOH; dbSNP:rs1665661372","featureCrossReferences":[{"database":"dbSNP","id":"rs1665661372"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28787104"}],"featureId":"VAR_088054","alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088055","alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088056","alternativeSequence":{"originalSequence":"H","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in IDDMOH; decreased function in positive regulation of DNA-templated transcription; compared to the wild-type, the mutant induces reduced GDF5 promoter activation using an in vitro reporter system; no effect on nuclear localization","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35938035"}],"featureId":"VAR_088057","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":116,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"in IDDMOH; decreases transcriptional activity; dbSNP:rs587777479","featureCrossReferences":[{"database":"dbSNP","id":"rs587777479"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24886874"}],"featureId":"VAR_071462","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"in IDDMOH; decreased function in positive regulation of DNA-templated transcription; compared to the wild-type, the mutant induces a reduced GDF5 promoter activation using an in vitro reporter system","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26543203"}],"featureId":"VAR_088058","alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"in IDDMOH; uncertain significance; no effect on nuclear localization","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35938035"}],"featureId":"VAR_088059","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"in IDDMOH; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088060","alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}},{"type":"Natural variant","location":{"start":{"value":234,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35341651"}],"featureId":"VAR_088061","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"in IDDMOH","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35938035"}],"featureId":"VAR_088062","alternativeSequence":{}},{"type":"Helix","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6T78"}]},{"type":"Helix","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6T78"}]},{"type":"Helix","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6T78"}]},{"type":"Helix","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6T78"}]},{"type":"Helix","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6T78"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"8666406","citationType":"journal article","authors":["Jay P.","Goze C.","Marsollier C.","Taviaux S.","Hardelin J.-P.","Koopman P.","Berta P."],"citationCrossReferences":[{"database":"PubMed","id":"8666406"},{"database":"DOI","id":"10.1006/geno.1995.9970"}],"title":"The human SOX11 gene: cloning, chromosomal assignment and tissue expression.","publicationDate":"1995","journal":"Genomics","firstPage":"541","lastPage":"545","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","DEVELOPMENTAL STAGE"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10574465","citationType":"journal article","authors":["Azuma T.","Ao S.","Saito Y.","Yano K.","Seki N.","Wakao H.","Masuho Y.","Muramatsu M."],"citationCrossReferences":[{"database":"PubMed","id":"10574465"},{"database":"DOI","id":"10.1093/dnares/6.5.357"}],"title":"Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region.","publicationDate":"1999","journal":"DNA Res.","firstPage":"357","lastPage":"360","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Neuroepithelium","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15815621","citationType":"journal article","authors":["Hillier L.W.","Graves T.A.","Fulton R.S.","Fulton L.A.","Pepin K.H.","Minx P.","Wagner-McPherson C.","Layman D.","Wylie K.","Sekhon M.","Becker M.C.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Kremitzki C.","Oddy L.","Du H.","Sun H.","Bradshaw-Cordum H.","Ali J.","Carter J.","Cordes M.","Harris A.","Isak A.","van Brunt A.","Nguyen C.","Du F.","Courtney L.","Kalicki J.","Ozersky P.","Abbott S.","Armstrong J.","Belter E.A.","Caruso L.","Cedroni M.","Cotton M.","Davidson T.","Desai A.","Elliott G.","Erb T.","Fronick C.","Gaige T.","Haakenson W.","Haglund K.","Holmes A.","Harkins R.","Kim K.","Kruchowski S.S.","Strong C.M.","Grewal N.","Goyea E.","Hou S.","Levy A.","Martinka S.","Mead K.","McLellan M.D.","Meyer R.","Randall-Maher J.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Shah N.","Swearengen-Shahid S.","Snider J.","Strong J.T.","Thompson J.","Yoakum M.","Leonard S.","Pearman C.","Trani L.","Radionenko M.","Waligorski J.E.","Wang C.","Rock S.M.","Tin-Wollam A.-M.","Maupin R.","Latreille P.","Wendl M.C.","Yang S.-P.","Pohl C.","Wallis J.W.","Spieth J.","Bieri T.A.","Berkowicz N.","Nelson J.O.","Osborne J.","Ding L.","Meyer R.","Sabo A.","Shotland Y.","Sinha P.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Jones T.A.","She X.","Ciccarelli F.D.","Izaurralde E.","Taylor J.","Schmutz J.","Myers R.M.","Cox D.R.","Huang X.","McPherson J.D.","Mardis E.R.","Clifton S.W.","Warren W.C.","Chinwalla A.T.","Eddy S.R.","Marra M.A.","Ovcharenko I.","Furey T.S.","Miller W.","Eichler E.E.","Bork P.","Suyama M.","Torrents D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"15815621"},{"database":"DOI","id":"10.1038/nature03466"}],"title":"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.","publicationDate":"2005","journal":"Nature","firstPage":"724","lastPage":"731","volume":"434"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"8332506","citationType":"journal article","authors":["Goze C.","Poulat F.","Berta P."],"citationCrossReferences":[{"database":"PubMed","id":"8332506"},{"database":"DOI","id":"10.1093/nar/21.12.2943"}],"title":"Partial cloning of SOX-11 and SOX-12, two new human SOX genes.","publicationDate":"1993","journal":"Nucleic Acids Res.","firstPage":"2943","lastPage":"2943","volume":"21"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 57-115"]},{"referenceNumber":5,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"24886874","citationType":"journal article","authors":["Tsurusaki Y.","Koshimizu E.","Ohashi H.","Phadke S.","Kou I.","Shiina M.","Suzuki T.","Okamoto N.","Imamura S.","Yamashita M.","Watanabe S.","Yoshiura K.","Kodera H.","Miyatake S.","Nakashima M.","Saitsu H.","Ogata K.","Ikegawa S.","Miyake N.","Matsumoto N."],"citationCrossReferences":[{"database":"PubMed","id":"24886874"},{"database":"DOI","id":"10.1038/ncomms5011"}],"title":"De novo SOX11 mutations cause Coffin-Siris syndrome.","publicationDate":"2014","journal":"Nat. Commun.","firstPage":"4011","lastPage":"4011","volume":"5"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","DEVELOPMENTAL STAGE","TISSUE SPECIFICITY","VARIANTS IDDMOH PRO-60 AND CYS-116","CHARACTERIZATION OF VARIANTS IDDMOH PRO-60 AND CYS-116"]},{"referenceNumber":7,"citation":{"id":"26543203","citationType":"journal article","authoringGroup":["DDD Collaboration"],"authors":["Hempel A.","Pagnamenta A.T.","Blyth M.","Mansour S.","McConnell V.","Kou I.","Ikegawa S.","Tsurusaki Y.","Matsumoto N.","Lo-Castro A.","Plessis G.","Albrecht B.","Battaglia A.","Taylor J.C.","Howard M.F.","Keays D.","Sohal A.S.","Kuehl S.J.","Kini U.","McNeill A."],"citationCrossReferences":[{"database":"PubMed","id":"26543203"},{"database":"DOI","id":"10.1136/jmedgenet-2015-103393"}],"title":"Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome.","publicationDate":"2016","journal":"J. Med. Genet.","firstPage":"152","lastPage":"162","volume":"53"},"referencePositions":["VARIANTS IDDMOH 29-CYS--TYR-441 DEL; ASN-50 AND HIS-120","CHARACTERIZATION OF VARIANTS IDDMOH ASN-50 AND HIS-120","FUNCTION"]},{"referenceNumber":8,"citation":{"id":"28787104","citationType":"journal article","authors":["Okamoto N.","Ehara E.","Tsurusaki Y.","Miyake N.","Matsumoto N."],"citationCrossReferences":[{"database":"PubMed","id":"28787104"},{"database":"DOI","id":"10.1111/cga.12242"}],"title":"Coffin-Siris syndrome and cardiac anomaly with a novel SOX11 mutation.","publicationDate":"2018","journal":"Congenit. Anom. (Kyoto)","firstPage":"105","lastPage":"107","volume":"58"},"referencePositions":["VARIANT IDDMOH VAL-102"]},{"referenceNumber":9,"citation":{"id":"33086258","citationType":"journal article","authors":["Wakim V.","Nair P.","Delague V.","Bizzari S.","Al-Ali M.T.","Castro C.","Gambarini A.","El-Hayek S.","Megarbane A."],"citationCrossReferences":[{"database":"PubMed","id":"33086258"},{"database":"DOI","id":"10.1097/mcd.0000000000000348"}],"title":"SOX11-related syndrome: report on a new case and review.","publicationDate":"2021","journal":"Clin. Dysmorphol.","firstPage":"44","lastPage":"49","volume":"30"},"referencePositions":["VARIANT IDDMOH ASN-49"]},{"referenceNumber":10,"citation":{"id":"35642566","citationType":"journal article","authors":["Alburaiky S.","Taylor J.","O'Grady G.","Thomson G.","Perry D.","England E.M.","Yap P."],"citationCrossReferences":[{"database":"PubMed","id":"35642566"},{"database":"DOI","id":"10.1002/ajmg.a.62851"}],"title":"Cochlear nerve deficiency in SOX11-related Coffin-Siris syndrome.","publicationDate":"2022","journal":"Am. J. Med. Genet. A","firstPage":"2460","lastPage":"2465","volume":"188"},"referencePositions":["VARIANTS IDDMOH ASP-76 AND PRO-100"]},{"referenceNumber":11,"citation":{"id":"33785884","citationType":"journal article","authors":["Hanker B.","Gillessen-Kaesbach G.","Huening I.","Luedecke H.J.","Wieczorek D."],"citationCrossReferences":[{"database":"PubMed","id":"33785884"},{"database":"DOI","id":"10.1038/s41431-021-00865-2"}],"title":"Maternal transmission of a mild Coffin-Siris syndrome phenotype caused by a SOX11 missense variant.","publicationDate":"2022","journal":"Eur. J. Hum. Genet.","firstPage":"126","lastPage":"132","volume":"30"},"referencePositions":["VARIANT IDDMOH SER-47"]},{"referenceNumber":12,"citation":{"id":"35938035","citationType":"journal article","authors":["Ding Y.","Chen J.","Tang Y.","Chen L.N.","Yao R.E.","Yu T.","Yin Y.","Wang X.","Wang J.","Li N."],"citationCrossReferences":[{"database":"PubMed","id":"35938035"},{"database":"DOI","id":"10.3389/fgene.2022.940776"}],"title":"Identification and functional analysis of novel SOX11 variants in Chinese patients with Coffin-Siris syndrome 9.","publicationDate":"2022","journal":"Front. Genet.","firstPage":"940776","lastPage":"940776","volume":"13"},"referencePositions":["VARIANTS IDDMOH HIS-113; GLY-142 AND 274-LYS--TYR-441 DEL","CHARACTERIZATION OF VARIANTS IDDMOH HIS-113 AND GLY-142","SUBCELLULAR LOCATION"]},{"referenceNumber":13,"citation":{"id":"35341651","citationType":"journal article","authoringGroup":["University of Washington Centre for Mendelian Genomics (UW-CMG)","Genomics England Research Consortium"],"authors":["Al-Jawahiri R.","Foroutan A.","Kerkhof J.","McConkey H.","Levy M.","Haghshenas S.","Rooney K.","Turner J.","Shears D.","Holder M.","Lefroy H.","Castle B.","Reis L.M.","Semina E.V.","Lachlan K.","Chandler K.","Wright T.","Clayton-Smith J.","Hug F.P.","Pitteloud N.","Bartoloni L.","Hoffjan S.","Park S.M.","Thankamony A.","Lees M.","Wakeling E.","Naik S.","Hanker B.","Girisha K.M.","Agolini E.","Giuseppe Z.","Alban Z.","Tessarech M.","Keren B.","Afenjar A.","Zweier C.","Reis A.","Smol T.","Tsurusaki Y.","Nobuhiko O.","Sekiguchi F.","Tsuchida N.","Matsumoto N.","Kou I.","Yonezawa Y.","Ikegawa S.","Callewaert B.","Freeth M.","Kleinendorst L.","Donaldson A.","Alders M.","De Paepe A.","Sadikovic B.","McNeill A."],"citationCrossReferences":[{"database":"PubMed","id":"35341651"},{"database":"DOI","id":"10.1016/j.gim.2022.02.013"}],"title":"SOX11 variants cause a neurodevelopmental disorder with infrequent ocular malformations and hypogonadotropic hypogonadism and with distinct DNA methylation profile.","publicationDate":"2022","journal":"Genet. Med.","firstPage":"1261","lastPage":"1273","volume":"24"},"referencePositions":["VARIANTS IDDMOH ASP-48; GLN-50; GLN-51; GLY-51; LEU-51; TRP-51; LEU-52; ARG-53; ILE-53; VAL-53; THR-55; LEU-56; THR-57; 59-TRP--TYR-441 DEL; CYS-64; LEU-64; PRO-64; SER-64; ASP-75; SER-84; ARG-87; LEU-98; PRO-106; PRO-109; GLU-176 AND 234-GLU--TYR-441 DEL"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U23752","properties":[{"key":"ProteinId","value":"AAB08518.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB028641","properties":[{"key":"ProteinId","value":"BAA88122.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC108025","properties":[{"key":"ProteinId","value":"AAX88930.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"X73038","properties":[{"key":"ProteinId","value":"CAA51519.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS1654.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"G01758","properties":[{"key":"EntryName","value":"G01758"}]},{"database":"PIR","id":"S34118","properties":[{"key":"EntryName","value":"S34118"}]},{"database":"RefSeq","id":"NP_003099.1","properties":[{"key":"NucleotideSequenceId","value":"NM_003108.4"}]},{"database":"PDB","id":"6T78","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A/B=33-138"}]},{"database":"PDB","id":"6T7A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.70 A"},{"key":"Chains","value":"K=33-138"}]},{"database":"PDB","id":"6T7C","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.00 A"},{"key":"Chains","value":"K/L=33-138"}]},{"database":"PDB","id":"6T7D","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.40 A"},{"key":"Chains","value":"K=33-138"}]},{"database":"PDBsum","id":"6T78","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6T7A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6T7C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6T7D","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-10391","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-10393","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-10394","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112547","properties":[{"key":"Interactions","value":"12"}]},{"database":"FunCoup","id":"P35716","properties":[{"key":"Number of interactors","value":"882"}]},{"database":"IntAct","id":"P35716","properties":[{"key":"Interactions","value":"4"}]},{"database":"NDEx","id":"IQUERY-CP-SOX11","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000322568","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"P35716","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SOX11","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1351142","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000322568","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"55146","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"625","properties":[{"key":"antibodies","value":"386 antibodies from 41 providers"}]},{"database":"DNASU","id":"6664","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000322002.5","properties":[{"key":"ProteinId","value":"ENSP00000322568.3"},{"key":"GeneId","value":"ENSG00000176887.7"}]},{"database":"GeneID","id":"6664","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6664","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000322002.5","properties":[{"key":"ProteinId","value":"ENSP00000322568.3"},{"key":"RefSeqNucleotideId","value":"NM_003108.4"},{"key":"RefSeqProteinId","value":"NP_003099.1"}]},{"database":"UCSC","id":"uc002qyj.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:11191","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA36028","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6664","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6664","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SOX11","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"SOX11","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11191","properties":[{"key":"GeneName","value":"SOX11"}]},{"database":"HPA","id":"ENSG00000176887","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain)"}]},{"database":"MalaCards","id":"SOX11","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"600898","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"615866","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000176887","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"1465","properties":[{"key":"Disease","value":"Coffin-Siris syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000176887","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0527","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000161652","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_043342_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VKCVFMD","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6247875at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P35716","properties":[{"key":"Number of GO annotations","value":"8 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P35716","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000176887","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6664","properties":[{"key":"hits","value":"20 hits in 1168 CRISPR screens"}]},{"database":"ChiTaRS","id":"SOX11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"SOX11","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6664","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P35716","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P35716","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"P35716","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000176887","properties":[{"key":"ExpressionPatterns","value":"Expressed in ganglionic eminence and 74 other cell types or tissues"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17934069"}]},{"database":"GO","id":"GO:0001228","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription activator activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19808959"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21124928"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007420","properties":[{"key":"GoTerm","value":"P:brain development"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048593","properties":[{"key":"GoTerm","value":"P:camera-type eye morphogenesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0061386","properties":[{"key":"GoTerm","value":"P:closure of optic fissure"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0061303","properties":[{"key":"GoTerm","value":"P:cornea development in camera-type eye"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048557","properties":[{"key":"GoTerm","value":"P:embryonic digestive tract morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048704","properties":[{"key":"GoTerm","value":"P:embryonic skeletal system morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0061029","properties":[{"key":"GoTerm","value":"P:eyelid development in camera-type eye"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0014009","properties":[{"key":"GoTerm","value":"P:glial cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060022","properties":[{"key":"GoTerm","value":"P:hard palate development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001822","properties":[{"key":"GoTerm","value":"P:kidney development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0002089","properties":[{"key":"GoTerm","value":"P:lens morphogenesis in camera-type eye"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060425","properties":[{"key":"GoTerm","value":"P:lung morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0010629","properties":[{"key":"GoTerm","value":"P:negative regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19808959"}]},{"database":"GO","id":"GO:0060253","properties":[{"key":"GoTerm","value":"P:negative regulation of glial cell proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19808959"}]},{"database":"GO","id":"GO:0050672","properties":[{"key":"GoTerm","value":"P:negative regulation of lymphocyte proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20624318"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19808959"}]},{"database":"GO","id":"GO:2000678","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription regulatory region DNA binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007399","properties":[{"key":"GoTerm","value":"P:nervous system development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060563","properties":[{"key":"GoTerm","value":"P:neuroepithelial cell differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030182","properties":[{"key":"GoTerm","value":"P:neuron differentiation"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"10574465"}]},{"database":"GO","id":"GO:0003357","properties":[{"key":"GoTerm","value":"P:noradrenergic neuron differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0014003","properties":[{"key":"GoTerm","value":"P:oligodendrocyte development"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003151","properties":[{"key":"GoTerm","value":"P:outflow tract morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030513","properties":[{"key":"GoTerm","value":"P:positive regulation of BMP signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0010628","properties":[{"key":"GoTerm","value":"P:positive regulation of gene expression"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19808959"}]},{"database":"GO","id":"GO:0035332","properties":[{"key":"GoTerm","value":"P:positive regulation of hippo signaling"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046887","properties":[{"key":"GoTerm","value":"P:positive regulation of hormone secretion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2001111","properties":[{"key":"GoTerm","value":"P:positive regulation of lens epithelial cell proliferation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050769","properties":[{"key":"GoTerm","value":"P:positive regulation of neurogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045666","properties":[{"key":"GoTerm","value":"P:positive regulation of neuron differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19808959"}]},{"database":"GO","id":"GO:0045778","properties":[{"key":"GoTerm","value":"P:positive regulation of ossification"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20626275"}]},{"database":"GO","id":"GO:0045669","properties":[{"key":"GoTerm","value":"P:positive regulation of osteoblast differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20626275"}]},{"database":"GO","id":"GO:2000648","properties":[{"key":"GoTerm","value":"P:positive regulation of stem cell proliferation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20626275"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21124928"}]},{"database":"GO","id":"GO:0017015","properties":[{"key":"GoTerm","value":"P:regulation of transforming growth factor beta receptor signaling pathway"},{"key":"GoEvidenceType","value":"IEP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000270","source":"PubMed","id":"20624318"}]},{"database":"GO","id":"GO:0060023","properties":[{"key":"GoTerm","value":"P:soft palate development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0021510","properties":[{"key":"GoTerm","value":"P:spinal cord development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048485","properties":[{"key":"GoTerm","value":"P:sympathetic nervous system development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060412","properties":[{"key":"GoTerm","value":"P:ventricular septum morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd22037","properties":[{"key":"EntryName","value":"HMG-box_SoxC_SOX11"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.30.10:FF:000007","properties":[{"key":"EntryName","value":"Transcription factor SOX"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.30.10","properties":[{"key":"EntryName","value":"High mobility group box domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009071","properties":[{"key":"EntryName","value":"HMG_box_dom"}]},{"database":"InterPro","id":"IPR036910","properties":[{"key":"EntryName","value":"HMG_box_dom_sf"}]},{"database":"InterPro","id":"IPR017386","properties":[{"key":"EntryName","value":"SOX-12/11/4"}]},{"database":"InterPro","id":"IPR050140","properties":[{"key":"EntryName","value":"SRY-related_HMG-box_TF-like"}]},{"database":"PANTHER","id":"PTHR10270","properties":[{"key":"EntryName","value":"SOX TRANSCRIPTION FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10270:SF113","properties":[{"key":"EntryName","value":"TRANSCRIPTION FACTOR SOX-11"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00505","properties":[{"key":"EntryName","value":"HMG_box"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF038098","properties":[{"key":"EntryName","value":"SOX-12/11/4a"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00398","properties":[{"key":"EntryName","value":"HMG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47095","properties":[{"key":"EntryName","value":"HMG-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50118","properties":[{"key":"EntryName","value":"HMG_BOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVQQAESLEAESNLPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKAGAGKAAQSGDYGGAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQLQIKQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRAGATSGAGGGSRLYYSFKNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGSSGEDADDLMFDLSLNFSQSAHSASEQQLGGGAAAGNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTPELSEMIAGDWLEANFSDLVFTY","length":441,"molWeight":46679,"crc64":"50567A654F503C63","md5":"624A85E415F9C14293B58EB0BBF5C792"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DISEASE":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"DNA binding":1,"Region":5,"Compositional bias":4,"Modified residue":1,"Natural variant":39,"Helix":5},"uniParcId":"UPI00001362AD"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q05CH0","uniProtkbId":"Q05CH0_HUMAN","entryAudit":{"firstPublicDate":"2006-11-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-11-14","entryVersion":89,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH25789.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH25789.1"}],"value":"SOX11 protein"}}],"flag":"Fragment"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH25789.1"}],"value":"SOX11"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004123"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00267"}],"value":"Nucleus","id":"SL-0191"}}]}],"features":[{"type":"Domain","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"HMG box","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50118"}]},{"type":"DNA binding","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"HMG box","evidences":[{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00267"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Non-terminal residue","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH25789.1"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023125"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00267"}],"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023242"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU00267"}],"id":"KW-0539","category":"Cellular component","name":"Nucleus"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"authors":["Gerhard D.S.","Wagner L.","Feingold E.A.","Shenmen C.M.","Grouse L.H.","Schuler G.","Klein S.L.","Old S.","Rasooly R.","Good P.","Guyer M.","Peck A.M.","Derge J.G.","Lipman D.","Collins F.S.","Jang W.","Sherry S.","Feolo M.","Misquitta L.","Lee E.","Rotmistrovsky K.","Greenhut S.F.","Schaefer C.F.","Buetow K.","Bonner T.I.","Haussler D.","Kent J.","Kiekhaus M.","Furey T.","Brent M.","Prange C.","Schreiber K.","Shapiro N.","Bhat N.K.","Hopkins R.F.","Hsie F.","Driscoll T.","Soares M.B.","Casavant T.L.","Scheetz T.E.","Brown-stein M.J.","Usdin T.B.","Toshiyuki S.","Carninci P.","Piao Y.","Dudekula D.B.","Ko M.S.","Kawakami K.","Suzuki Y.","Sugano S.","Gruber C.E.","Smith M.R.","Simmons B.","Moore T.","Waterman R.","Johnson S.L.","Ruan Y.","Wei C.L.","Mathavan S.","Gunaratne P.H.","Wu J.","Garcia A.M.","Hulyk S.W.","Fuh E.","Yuan Y.","Sneed A.","Kowis C.","Hodgson A.","Muzny D.M.","McPherson J.","Gibbs R.A.","Fahey J.","Helton E.","Ketteman M.","Madan A.","Rodrigues S.","Sanchez A.","Whiting M.","Madari A.","Young A.C.","Wetherby K.D.","Granite S.J.","Kwong P.N.","Brinkley C.P.","Pearson R.L.","Bouffard G.G.","Blakesly R.W.","Green E.D.","Dickson M.C.","Rodriguez A.C.","Grimwood J.","Schmutz J.","Myers R.M.","Butterfield Y.S.","Griffith M.","Griffith O.L.","Krzywinski M.I.","Liao N.","Morin R.","Morrin R.","Palmquist D.","Petrescu A.S.","Skalska U.","Smailus D.E.","Stott J.M.","Schnerch A.","Schein J.E.","Jones S.J.","Holt R.A.","Baross A.","Marra M.A.","Clifton S.","Makowski K.A.","Bosak S.","Malek J."],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH25789.1"}],"value":"Lung","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AAH25789.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC025789","properties":[{"key":"ProteinId","value":"AAH25789.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"AlphaFoldDB","id":"Q05CH0","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q05CH0","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6247875at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"SOX11","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"CDD","id":"cd22037","properties":[{"key":"EntryName","value":"HMG-box_SoxC_SOX11"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.30.10:FF:000007","properties":[{"key":"EntryName","value":"Transcription factor SOX"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.30.10","properties":[{"key":"EntryName","value":"High mobility group box domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR009071","properties":[{"key":"EntryName","value":"HMG_box_dom"}]},{"database":"InterPro","id":"IPR036910","properties":[{"key":"EntryName","value":"HMG_box_dom_sf"}]},{"database":"InterPro","id":"IPR050140","properties":[{"key":"EntryName","value":"SRY-related_HMG-box_TF-like"}]},{"database":"PANTHER","id":"PTHR10270","properties":[{"key":"EntryName","value":"SOX TRANSCRIPTION FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10270:SF113","properties":[{"key":"EntryName","value":"TRANSCRIPTION FACTOR SOX-11"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00505","properties":[{"key":"EntryName","value":"HMG_box"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00398","properties":[{"key":"EntryName","value":"HMG"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47095","properties":[{"key":"EntryName","value":"HMG-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50118","properties":[{"key":"EntryName","value":"HMG_BOX_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MVQQAESLEAESNLPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAP","length":173,"molWeight":19038,"crc64":"F035B51DEE82D255","md5":"1EC0DC39FF0CCF908599DD043C2FBF8C"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Domain":1,"DNA binding":1,"Region":2,"Compositional bias":2,"Non-terminal residue":1},"uniParcId":"UPI0000D49A7F"}}]}