{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q16143","secondaryAccessions":["Q6IAX7"],"uniProtkbId":"SYUB_HUMAN","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":205,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Beta-synuclein"}}},"genes":[{"geneName":{"value":"SNCB"}}],"comments":[{"texts":[{"value":"Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q16143","intActId":"EBI-727106"},"interactantTwo":{"uniProtKBAccession":"P05067","geneName":"APP","intActId":"EBI-77613"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q16143","intActId":"EBI-727106"},"interactantTwo":{"uniProtKBAccession":"Q9UNS2","geneName":"COPS3","intActId":"EBI-350590"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q16143","intActId":"EBI-727106"},"interactantTwo":{"uniProtKBAccession":"Q8NDC4","geneName":"MORN4","intActId":"EBI-10269566"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q16143","intActId":"EBI-727106"},"interactantTwo":{"uniProtKBAccession":"O75925","geneName":"PIAS1","intActId":"EBI-629434"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q16143","intActId":"EBI-727106"},"interactantTwo":{"uniProtKBAccession":"Q8N488","geneName":"RYBP","intActId":"EBI-752324"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q16143","intActId":"EBI-727106"},"interactantTwo":{"uniProtKBAccession":"Q9GZS3","geneName":"SKIC8","intActId":"EBI-358545"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q16143","intActId":"EBI-727106"},"interactantTwo":{"uniProtKBAccession":"P37840","geneName":"SNCA","intActId":"EBI-985879"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"value":"Expressed predominantly in brain; concentrated in presynaptic nerve terminals"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10852916"}],"value":"Phosphorylated. Phosphorylation by G protein-coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Beta-synuclein","featureId":"PRO_0000184035"},{"type":"Repeat","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":30,"modifier":"EXACT"}},"description":"1"},{"type":"Repeat","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"2"},{"type":"Repeat","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"3; approximate"},{"type":"Repeat","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"4"},{"type":"Region","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)"},{"type":"Region","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"Phosphoserine; by GRK2, CK2 and GRK5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10852916"}]}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"8194594","citationType":"journal article","authors":["Jakes R.","Spillantini M.G.","Goedert M."],"citationCrossReferences":[{"database":"PubMed","id":"8194594"},{"database":"DOI","id":"10.1016/0014-5793(94)00395-5"}],"title":"Identification of two distinct synucleins from human brain.","publicationDate":"1994","journal":"FEBS Lett.","firstPage":"27","lastPage":"32","volume":"345"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","PARTIAL PROTEIN SEQUENCE"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"9806846","citationType":"journal article","authors":["Lavedan C.","Leroy E.","Torres R.","Dehejia A.","Dutra A.","Buchholtz S.","Nussbaum R.L.","Polymeropoulos M.H."],"citationCrossReferences":[{"database":"PubMed","id":"9806846"},{"database":"DOI","id":"10.1006/geno.1998.5556"}],"title":"Genomic organization and expression of the human beta-synuclein gene (SNCB).","publicationDate":"1998","journal":"Genomics","firstPage":"173","lastPage":"175","volume":"54"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-4IUTJLP3044AK","citationType":"submission","authors":["Kalnine N.","Chen X.","Rolfs A.","Halleck A.","Hines L.","Eisenstein S.","Koundinya M.","Raphael J.","Moreira D.","Kelley T.","LaBaer J.","Lin Y.","Phelan M.","Farmer A."],"title":"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.","publicationDate":"MAY-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"CI-D49P6QQO8F5LU","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"CI-652NQH91LIDA8","citationType":"submission","authors":["Lubec G.","Chen W.-Q.","Sun Y."],"publicationDate":"DEC-2008","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 46-85","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"Fetal brain cortex","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"10852916","citationType":"journal article","authors":["Pronin A.N.","Morris A.J.","Surguchov A.","Benovic J.L."],"citationCrossReferences":[{"database":"PubMed","id":"10852916"},{"database":"DOI","id":"10.1074/jbc.m003542200"}],"title":"Synucleins are a novel class of substrates for G protein-coupled receptor kinases.","publicationDate":"2000","journal":"J. Biol. Chem.","firstPage":"26515","lastPage":"26522","volume":"275"},"referencePositions":["PHOSPHORYLATION AT SER-118"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"S69965","properties":[{"key":"ProteinId","value":"AAB30860.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF053136","properties":[{"key":"ProteinId","value":"AAC80286.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF053134","properties":[{"key":"ProteinId","value":"AAC80286.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF053135","properties":[{"key":"ProteinId","value":"AAC80286.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT006627","properties":[{"key":"ProteinId","value":"AAP35273.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR457027","properties":[{"key":"ProteinId","value":"CAG33308.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC002902","properties":[{"key":"ProteinId","value":"AAH02902.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS4406.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S44430","properties":[{"key":"EntryName","value":"S44430"}]},{"database":"RefSeq","id":"NP_001001502.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001001502.3"}]},{"database":"RefSeq","id":"NP_001350069.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001363140.2"}]},{"database":"RefSeq","id":"NP_003076.1","properties":[{"key":"NucleotideSequenceId","value":"NM_003085.5"}]},{"database":"AlphaFoldDB","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112504","properties":[{"key":"Interactions","value":"22"}]},{"database":"FunCoup","id":"Q16143","properties":[{"key":"Number of interactors","value":"142"}]},{"database":"IntAct","id":"Q16143","properties":[{"key":"Interactions","value":"16"}]},{"database":"MINT","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-SNCB","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000377296","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.C.77.1.2","properties":[{"key":"FamilyName","value":"the synuclein (synuclein) family"}]},{"database":"GlyCosmos","id":"Q16143","properties":[{"key":"glycosylation","value":"3 sites, 1 glycan"}]},{"database":"GlyGen","id":"Q16143","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (3 sites)"}]},{"database":"iPTMnet","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SNCB","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"2501105","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000377296","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"60833","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3634","properties":[{"key":"antibodies","value":"389 antibodies from 42 providers"}]},{"database":"DNASU","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000310112.7","properties":[{"key":"ProteinId","value":"ENSP00000308057.3"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000393693.7","properties":[{"key":"ProteinId","value":"ENSP00000377296.2"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000506696.1","properties":[{"key":"ProteinId","value":"ENSP00000422223.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000510387.5","properties":[{"key":"ProteinId","value":"ENSP00000424073.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000862608.1","properties":[{"key":"ProteinId","value":"ENSP00000532667.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000862609.1","properties":[{"key":"ProteinId","value":"ENSP00000532668.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000862611.1","properties":[{"key":"ProteinId","value":"ENSP00000532670.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000912556.1","properties":[{"key":"ProteinId","value":"ENSP00000582615.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000912558.1","properties":[{"key":"ProteinId","value":"ENSP00000582617.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000912559.1","properties":[{"key":"ProteinId","value":"ENSP00000582618.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000946187.1","properties":[{"key":"ProteinId","value":"ENSP00000616246.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000946191.1","properties":[{"key":"ProteinId","value":"ENSP00000616250.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000946192.1","properties":[{"key":"ProteinId","value":"ENSP00000616251.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000946194.1","properties":[{"key":"ProteinId","value":"ENSP00000616253.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000946195.1","properties":[{"key":"ProteinId","value":"ENSP00000616254.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000946197.1","properties":[{"key":"ProteinId","value":"ENSP00000616256.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000946198.1","properties":[{"key":"ProteinId","value":"ENSP00000616257.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"GeneID","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6620","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000393693.7","properties":[{"key":"ProteinId","value":"ENSP00000377296.2"},{"key":"RefSeqNucleotideId","value":"NM_003085.5"},{"key":"RefSeqProteinId","value":"NP_003076.1"}]},{"database":"UCSC","id":"uc003mep.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:11140","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA35988","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SNCB","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11140","properties":[{"key":"GeneName","value":"SNCB"}]},{"database":"HPA","id":"ENSG00000074317","properties":[{"key":"ExpressionPatterns","value":"Group enriched (brain, retina)"}]},{"database":"MalaCards","id":"SNCB","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"602569","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S0N5","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183175","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_129378_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GWRERWM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9944634at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q16143","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-5660489","properties":[{"key":"PathwayName","value":"MTF1 activates gene expression"}]},{"database":"SignaLink","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000074317","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6620","properties":[{"key":"hits","value":"16 hits in 1150 CRISPR screens"}]},{"database":"ChiTaRS","id":"SNCB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Beta-synuclein","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q16143","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q16143","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"Q16143","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000074317","properties":[{"key":"ExpressionPatterns","value":"Expressed in right hemisphere of cerebellum and 138 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q16143","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0043679","properties":[{"key":"GoTerm","value":"C:axon terminus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0016234","properties":[{"key":"GoTerm","value":"C:inclusion body"},{"key":"GoEvidenceType","value":"IDA:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17222866"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11312271"}]},{"database":"GO","id":"GO:1903136","properties":[{"key":"GoTerm","value":"F:cuprous ion binding"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25495902"}]},{"database":"GO","id":"GO:0004859","properties":[{"key":"GoTerm","value":"F:phospholipase inhibitor activity"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"9806846"}]},{"database":"GO","id":"GO:0046914","properties":[{"key":"GoTerm","value":"F:transition metal ion binding"},{"key":"GoEvidenceType","value":"IMP:CAFA"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25495902"}]},{"database":"GO","id":"GO:0007268","properties":[{"key":"GoTerm","value":"P:chemical synaptic transmission"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0050808","properties":[{"key":"GoTerm","value":"P:synapse organization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048488","properties":[{"key":"GoTerm","value":"P:synaptic vesicle endocytosis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"DisProt","id":"DP00555","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"1.10.287.700:FF:000001","properties":[{"key":"EntryName","value":"Alpha-synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA","length":134,"molWeight":14288,"crc64":"5BCA9FCA615AC4EF","md5":"E5AC3D66BFB3E5FDB168AD4D33E145BA"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":7,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Repeat":4,"Region":2,"Compositional bias":1,"Modified residue":1},"uniParcId":"UPI000003173C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UGW7","uniProtkbId":"A0ACI8UGW7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616252.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Beta-synuclein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616252.1"}],"value":"SNCB"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009147"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":98,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UGW7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UGW7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616252.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616252.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616252.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616252.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC091934","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946188.1","properties":[{"key":"ProteinId","value":"ENSP00000616247.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000946193.1","properties":[{"key":"ProteinId","value":"ENSP00000616252.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"HGNC","id":"HGNC:11140","properties":[{"key":"GeneName","value":"SNCB"}]},{"database":"OpenTargets","id":"ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183175","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"FunFam","id":"1.10.287.700:FF:000001","properties":[{"key":"EntryName","value":"Alpha-synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEYQEYEPEA","length":133,"molWeight":14159,"crc64":"1043A6010A9922B0","md5":"E8304D54BA1BB4E31C3C6FA1EDB973F8"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI00403267EB"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UH44","uniProtkbId":"A0ACI8UH44_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616249.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Beta-synuclein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616249.1"}],"value":"SNCB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009147"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UH44"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616249.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616249.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616249.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616249.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC091934","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946190.1","properties":[{"key":"ProteinId","value":"ENSP00000616249.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"HGNC","id":"HGNC:11140","properties":[{"key":"GeneName","value":"SNCB"}]},{"database":"OpenTargets","id":"ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183175","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA","length":114,"molWeight":12319,"crc64":"C3F5B9570D32D6E9","md5":"89F11F67EB6ABF0267E38B13544383FA"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI00403222F8"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G4Y815","uniProtkbId":"G4Y815_HUMAN","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2025-04-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":51,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEQ54757.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Beta-synuclein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEQ54757.1"}],"value":"SNCB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009147"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2BMR49UKVLLGF","citationType":"submission","authors":["Beyer K.","Ariza A."],"title":"Brain specific minor SNCB transcript variants and their expression in Lewy body diseases.","publicationDate":"MAY-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEQ54757.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEQ54757.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF960951","properties":[{"key":"ProteinId","value":"AEQ54757.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"JF960953","properties":[{"key":"ProteinId","value":"AEQ54759.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001304964.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318035.2"}]},{"database":"RefSeq","id":"NP_001304966.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318037.2"}]},{"database":"AlphaFoldDB","id":"G4Y815","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"G4Y815","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9944634at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"6620","properties":[{"key":"hits","value":"16 hits in 1150 CRISPR screens"}]},{"database":"ChiTaRS","id":"SNCB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKEEYQEYEPEA","length":104,"molWeight":10952,"crc64":"AF07685F7A8A2B15","md5":"EE0D95A93ECD7C35CFEF2423F19FC2E8"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"uniParcId":"UPI00022DD57E"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8SLF1","uniProtkbId":"A0ACI8SLF1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000582616.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Beta-synuclein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000582616.1"}],"value":"SNCB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009147"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8SLF1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8SLF1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000582616.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000582616.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000582616.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000582616.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC091934","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000912557.1","properties":[{"key":"ProteinId","value":"ENSP00000582616.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"HGNC","id":"HGNC:11140","properties":[{"key":"GeneName","value":"SNCB"}]},{"database":"OpenTargets","id":"ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183175","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"2"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGILQMLGFHSEQERMVPDLLMVIQSISAVRVDIQWLPEENASSLSNKRGAGLQKSQVQRPWGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA","length":195,"molWeight":21174,"crc64":"1903B4A96D14E8D8","md5":"BC08EE51FCE631694F871E06E16D324E"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":2,"Compositional bias":2},"uniParcId":"UPI0040324395"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0A087WVK3","uniProtkbId":"A0A087WVK3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000479489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Beta-synuclein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000479489.1"}],"value":"SNCB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009147"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0A087WVK3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0A087WVK3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000479489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000479489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000479489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000479489.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC091934","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001304963.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318034.2"}]},{"database":"RefSeq","id":"NP_001304965.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318036.2"}]},{"database":"DNASU","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000614675.4","properties":[{"key":"ProteinId","value":"ENSP00000479489.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"GeneID","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:11140","properties":[{"key":"GeneName","value":"SNCB"}]},{"database":"OpenTargets","id":"ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183175","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_129378_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9944634at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"6620","properties":[{"key":"hits","value":"16 hits in 1150 CRISPR screens"}]},{"database":"ChiTaRS","id":"SNCB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"Bgee","id":"ENSG00000074317","properties":[{"key":"ExpressionPatterns","value":"Expressed in right hemisphere of cerebellum and 138 other cell types or tissues"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA","length":120,"molWeight":12931,"crc64":"B4F318D2A3CEA74D","md5":"FA5F46D2097A72DD7D38E9DA190498A7"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":2},"uniParcId":"UPI0000D9B77B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"G4Y816","uniProtkbId":"G4Y816_HUMAN","entryAudit":{"firstPublicDate":"2011-12-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-12-14","entryVersion":93,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEQ54758.1"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Beta-synuclein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEQ54758.1"}],"value":"SNCB"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009147"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2BMR49UKVLLGF","citationType":"submission","authors":["Beyer K.","Ariza A."],"title":"Brain specific minor SNCB transcript variants and their expression in Lewy body diseases.","publicationDate":"MAY-2011","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEQ54758.1"}],"value":"Brain","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000313","source":"EMBL","id":"AEQ54758.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"JF960950","properties":[{"key":"ProteinId","value":"AEQ54756.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"JF960952","properties":[{"key":"ProteinId","value":"AEQ54758.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001304963.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318034.2"}]},{"database":"RefSeq","id":"NP_001304965.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318036.2"}]},{"database":"AlphaFoldDB","id":"G4Y816","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"3634","properties":[{"key":"antibodies","value":"389 antibodies from 42 providers"}]},{"database":"DNASU","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc021yig.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6620","properties":[{"key":"Description","value":"-"}]},{"database":"OpenTargets","id":"ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183175","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_129378_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9944634at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"6620","properties":[{"key":"hits","value":"16 hits in 1150 CRISPR screens"}]},{"database":"ChiTaRS","id":"SNCB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Bgee","id":"ENSG00000074317","properties":[{"key":"ExpressionPatterns","value":"Expressed in right hemisphere of cerebellum and 138 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA","length":120,"molWeight":12931,"crc64":"B4F318D2A3CEA74D","md5":"FA5F46D2097A72DD7D38E9DA190498A7"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":2},"uniParcId":"UPI0000D9B77B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8PTW9","uniProtkbId":"A0ACI8PTW9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532671.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Beta-synuclein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532671.1"}],"value":"SNCB"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009147"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8PTW9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8PTW9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532671.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532671.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532671.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532671.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC091934","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000862612.1","properties":[{"key":"ProteinId","value":"ENSP00000532671.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000946196.1","properties":[{"key":"ProteinId","value":"ENSP00000616255.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"HGNC","id":"HGNC:11140","properties":[{"key":"GeneName","value":"SNCB"}]},{"database":"OpenTargets","id":"ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183175","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"FunFam","id":"1.10.287.700:FF:000001","properties":[{"key":"EntryName","value":"Alpha-synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA","length":126,"molWeight":13590,"crc64":"CF1342935F9BBBEB","md5":"4A45958F2A9AB68D8788BCDE149956AB"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":1},"uniParcId":"UPI0010A20648"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QVY6","uniProtkbId":"A0ACI8QVY6_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532672.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Beta-synuclein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532672.1"}],"value":"SNCB"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009147"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QVY6"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QVY6"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532672.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532672.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532672.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000532672.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC091934","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000862610.1","properties":[{"key":"ProteinId","value":"ENSP00000532669.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"Ensembl","id":"ENST00000862613.1","properties":[{"key":"ProteinId","value":"ENSP00000532672.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"HGNC","id":"HGNC:11140","properties":[{"key":"GeneName","value":"SNCB"}]},{"database":"OpenTargets","id":"ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183175","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"FunFam","id":"1.10.287.700:FF:000001","properties":[{"key":"EntryName","value":"Alpha-synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA","length":130,"molWeight":13974,"crc64":"90370837C387891B","md5":"24A22CC5D1D9247FC4B35041E01BC1B2"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":2},"uniParcId":"UPI00025757A3"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8UGV7","uniProtkbId":"A0ACI8UGV7_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616248.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Beta-synuclein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616248.1"}],"value":"SNCB"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004496"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00009147"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361225"}],"value":"Belongs to the synuclein family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Region","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022490"}],"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8UGV7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8UGV7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616248.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616248.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616248.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000616248.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC091934","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000946189.1","properties":[{"key":"ProteinId","value":"ENSP00000616248.1"},{"key":"GeneId","value":"ENSG00000074317.12"}]},{"database":"HGNC","id":"HGNC:11140","properties":[{"key":"GeneName","value":"SNCB"}]},{"database":"OpenTargets","id":"ENSG00000074317","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00950000183175","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"FunFam","id":"1.10.287.700:FF:000001","properties":[{"key":"EntryName","value":"Alpha-synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.700","properties":[{"key":"EntryName","value":"Helix hairpin bin"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001058","properties":[{"key":"EntryName","value":"Synuclein"}]},{"database":"InterPro","id":"IPR002461","properties":[{"key":"EntryName","value":"Synuclein_beta"}]},{"database":"PANTHER","id":"PTHR13820:SF4","properties":[{"key":"EntryName","value":"BETA-SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13820","properties":[{"key":"EntryName","value":"SYNUCLEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01387","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01213","properties":[{"key":"EntryName","value":"BSYNUCLEIN"}]},{"database":"PRINTS","id":"PR01211","properties":[{"key":"EntryName","value":"SYNUCLEIN"}]},{"database":"SUPFAM","id":"SSF118375","properties":[{"key":"EntryName","value":"Synuclein"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEYQEYEPEA","length":129,"molWeight":13844,"crc64":"CDD45BA3D7D4D62E","md5":"1D253866794DBEEE756D0BB670D43150"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Region":1,"Compositional bias":2},"uniParcId":"UPI004031EF62"}}]}