{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q969G3","secondaryAccessions":["B3KMC1","B4DFR4","C0IMW4","C0IMW5","C0IMW7","H7C3F6","O43539"],"uniProtkbId":"SMCE1_HUMAN","entryAudit":{"firstPublicDate":"2004-10-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-10-25","entryVersion":210,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1"}},"alternativeNames":[{"fullName":{"value":"BRG1-associated factor 57"},"shortNames":[{"value":"BAF57"}]}]},"genes":[{"geneName":{"value":"SMARCE1"},"synonyms":[{"value":"BAF57"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O54941"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12672490"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22952240"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26601204"}],"value":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O54941"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q56A18"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12192000"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12917342"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16051670"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18765789"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12672490"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22952240"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26601204"}],"value":"Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (PubMed:12672490, PubMed:22952240, PubMed:26601204). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3 (PubMed:18765789). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (ACTB) (PubMed:22952240, PubMed:26601204). Interacts with BRDT (By similarity). Also binds to the SRC/p160 family of histone acetyltransferases (HATs) composed of NCOA1, NCOA2, and NCOA3. Interacts with RCOR1/CoREST, NR3C1 and ZMIM2/ZIMP7 (PubMed:12192000, PubMed:12917342, PubMed:16051670)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q9Y2J4","geneName":"AMOTL2","intActId":"EBI-746752"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q9Y2J4-4","geneName":"AMOTL2","intActId":"EBI-10187270"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q68CP9","geneName":"ARID2","intActId":"EBI-637818"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q9HCU9","geneName":"BRMS1","intActId":"EBI-714781"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q96JN2-2","geneName":"CCDC136","intActId":"EBI-10171416"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"P0C7W6","geneName":"CCDC172","intActId":"EBI-2548868"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"G5E9W6","geneName":"CCDC183","intActId":"EBI-17212717"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q8TD31-3","geneName":"CCHCR1","intActId":"EBI-10175300"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q01850","geneName":"CDR2","intActId":"EBI-1181367"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q96L14","geneName":"CEP170P1","intActId":"EBI-743488"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q96MT8","geneName":"CEP63","intActId":"EBI-741977"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q96MT8-3","geneName":"CEP63","intActId":"EBI-11522539"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q8NHQ1","geneName":"CEP70","intActId":"EBI-739624"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"A8MQ03","geneName":"CYSRT1","intActId":"EBI-3867333"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q9NRI5-2","geneName":"DISC1","intActId":"EBI-11988027"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q12929","geneName":"EPS8","intActId":"EBI-375576"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q96A65-2","geneName":"EXOC4","intActId":"EBI-17869840"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q9UPT5","geneName":"EXOC7","intActId":"EBI-720048"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q9NTX9","geneName":"FAM217B","intActId":"EBI-19153639"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"A1L4K1","geneName":"FSD2","intActId":"EBI-5661036"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"A6NEM1","geneName":"GOLGA6L9","intActId":"EBI-5916454"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q969G3","intActId":"EBI-455078"},"interactantTwo":{"uniProtKBAccession":"Q4V328","geneName":"GRIPAP1","intActId"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