{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"O94956","secondaryAccessions":["A0A024R5I4","A8K2G9","B4DGA9","B4DTB0","E7ERN5","E9PPU8","Q9H2Z0","Q9UFU1"],"uniProtkbId":"SO2B1_HUMAN","entryAudit":{"firstPublicDate":"2000-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-01-24","entryVersion":197,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Solute carrier organic anion transporter family member 2B1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16754786"}],"value":"Organic anion transporter B"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10873595"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16754786"}],"value":"OATP-B"}]},{"fullName":{"value":"Organic anion transporter polypeptide-related protein 2"},"shortNames":[{"value":"OATP-RP2"},{"value":"OATPRP2"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16908597"}],"value":"Organic anion transporting polypeptide 2B1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16908597"}],"value":"OATP2B1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11159893"}],"value":"Solute carrier family 21 member 9"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:10962"}],"value":"SLCO2B1"},"synonyms":[{"value":"KIAA0880"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16908597"}],"value":"OATP2B1"},{"value":"OATPB"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11159893"}],"value":"SLC21A9"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10873595"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11159893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11932330"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12409283"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724351"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610227"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16908597"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18501590"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20507927"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22201122"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23531488"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25132355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26277985"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26383540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27576593"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29871943"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34628357"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35714613"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.25"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35307651"}],"value":"Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions (PubMed:10873595, PubMed:11159893, PubMed:11932330, PubMed:12724351, PubMed:14610227, PubMed:16908597, PubMed:18501590, PubMed:20507927, PubMed:22201122, PubMed:23531488, PubMed:25132355, PubMed:26383540, PubMed:27576593, PubMed:28408210, PubMed:29871943, PubMed:34628357). Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S) (PubMed:11932330, PubMed:12409283). Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver (PubMed:11159893). Mediates the intestinal uptake of sulfated steroids (PubMed:12724351, PubMed:28408210). Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain (PubMed:16908597, PubMed:25132355). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May act as a heme transporter that promotes cellular iron availability via heme oxygenase/HMOX2 and independently of TFRC (PubMed:35714613). Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (PubMed:26383540). Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 (PubMed:10873595, PubMed:14610227, PubMed:19129463, PubMed:29871943, Ref.25). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:14610227, PubMed:19129463, PubMed:22201122). The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound (PubMed:19129463, PubMed:20507927, PubMed:26277985). Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions (PubMed:19129463). Cytoplasmic glutamate may also act as counteranion in the placenta (PubMed:26277985). An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) (PubMed:20507927)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23531488"}],"value":"Has estrone 3-sulfate (E1S) transport activity comparable with the full-length isoform 1"}],"commentType":"FUNCTION","molecule":"Isoform 3"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71839"},{"database":"ChEBI","id":"CHEBI:57905"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11159893"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"14610227"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16908597"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18501590"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23531488"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26277985"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34628357"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"estrone 3-sulfate(out) = estrone 3-sulfate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71835"},{"database":"ChEBI","id":"CHEBI:60050"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28408210"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"10873595"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11159893"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11932330"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"12724351"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"14610227"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16908597"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18501590"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19129463"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20507927"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22201122"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23531488"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26277985"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26383540"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27576593"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"29871943"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34628357"},{"evidenceCode":"ECO:0000305","source":"Reference","id":"Ref.25"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"estrone 3-sulfate(out) + hydrogencarbonate(in) = estrone 3-sulfate(in) + hydrogencarbonate(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73055"},{"database":"ChEBI","id":"CHEBI:17544"},{"database":"ChEBI","id":"CHEBI:60050"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"taurocholate(out) = taurocholate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71703"},{"database":"ChEBI","id":"CHEBI:36257"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"14610227"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"29871943"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"coproporphyrin III(out) = coproporphyrin III(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74363"},{"database":"ChEBI","id":"CHEBI:131725"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"26383540"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"substance P(out) = substance P(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:74367"},{"database":"ChEBI","id":"CHEBI:190692"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25132355"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"pregnenolone sulfate(out) = pregnenolone sulfate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73023"},{"database":"ChEBI","id":"CHEBI:133000"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16908597"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34628357"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E2(out) = prostaglandin E2(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50984"},{"database":"ChEBI","id":"CHEBI:606564"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"10873595"},{"evidenceCode":"ECO:0000305","source":"Reference","id":"Ref.25"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin D2(out) = prostaglandin D2(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50976"},{"database":"ChEBI","id":"CHEBI:57406"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9JHI3"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-thyroxine(out) = L-thyroxine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71819"},{"database":"ChEBI","id":"CHEBI:58448"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19129463"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16908597"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.25"}],"value":"E1S, DHEA-S and PregS transports are regulated by steroid hormones. In the case of testosterone, transport of E1S and DHEA-S was inhibited, whereas progesterone stimulated E1S, DHEA-S and PregS uptake (PubMed:16908597). Progesterone stimulates high-affinity uptake of E1S whereas it inhibits low-affinity uptake of E1S (Ref.25). Progesterone doesn't affect the uptake of PGE2 (Ref.25)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"maximumVelocities":[{"velocity":2135.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone 3-sulfate as substrate (at pH 5.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610227"}]},{"velocity":1293.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone-3-sulfate as substrate (at pH 6.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}]},{"velocity":12300.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone 3-sulfate as substrate (at pH 7.2)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11932330"}]},{"velocity":169.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone 3-sulfate as substrate (at pH 7.3)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16908597"}]},{"velocity":585.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone 3-sulfate as substrate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18501590"}]},{"velocity":351.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone 3-sulfate as substrate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29871943"}]},{"velocity":300.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone 3-sulfate as substrate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610227"}]},{"velocity":182.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone 3-sulfate as substrate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27576593"}]},{"velocity":209.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone 3-sulfate as substrate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20507927"}]},{"velocity":1400.0,"unit":"pmol/min/mg","enzyme":"enzyme with estrone-3-sulfate as substrate (at pH 8.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}]},{"velocity":602.0,"unit":"pmol/min/mg","enzyme":"enzyme with dehydroepiandrosterone sulfate as substrate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18501590"}]},{"velocity":5.76,"unit":"pmol/min/mg","enzyme":"enzyme with L-thyroxine as substrate (at pH 6.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}]},{"velocity":7.28,"unit":"pmol/min/mg","enzyme":"enzyme with L-thyroxine as substrate (at pH 8.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}]},{"velocity":546.0,"unit":"pmol/min/mg","enzyme":"enzyme with taurocholate as substrate (at pH 5.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610227"}]},{"velocity":19.0,"unit":"pmol/min/mg","enzyme":"enzyme with coproporphyrin III as substrate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26383540"}]}],"michaelisConstants":[{"constant":13.1,"unit":"uM","substrate":"estrone 3-sulfate (at pH 5.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610227"}]},{"constant":9.36,"unit":"uM","substrate":"estrone-3-sulfate (at pH 6.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}]},{"constant":35.0,"unit":"uM","substrate":"estrone 3-sulfate (at pH 7.2)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11932330"}]},{"constant":14.0,"unit":"uM","substrate":"estrone 3-sulfate (at pH 7.3)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16908597"}]},{"constant":6.4,"unit":"uM","substrate":"estrone 3-sulfate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29871943"}]},{"constant":19.1,"unit":"uM","substrate":"estrone 3-sulfate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18501590"}]},{"constant":8.09,"unit":"uM","substrate":"estrone 3-sulfate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610227"}]},{"constant":7.1,"unit":"uM","substrate":"estrone 3-sulfate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27576593"}]},{"constant":6.76,"unit":"uM","substrate":"estrone 3-sulfate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27576593"}]},{"constant":16.0,"unit":"uM","substrate":"estrone 3-sulfate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20507927"}]},{"constant":6.3,"unit":"uM","substrate":"estrone 3-sulfate (at pH 7.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11159893"}]},{"constant":17.7,"unit":"uM","substrate":"estrone-3-sulfate (at pH 8.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}]},{"constant":29.9,"unit":"uM","substrate":"estrone 3-sulfate for the low-affinity site (at pH 6.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22201122"}]},{"constant":51.4,"unit":"uM","substrate":"estrone 3-sulfate for the low-affinity site (at pH 6.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.25"}]},{"constant":0.1,"unit":"uM","substrate":"estrone 3-sulfate for the high-affinity site (at pH 6.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22201122"}]},{"constant":0.463,"unit":"uM","substrate":"estrone 3-sulfate for the high-affinity site (at pH 6.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.25"}]},{"constant":201.8,"unit":"uM","substrate":"dehydroepiandrosterone sulfate (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18501590"}]},{"constant":0.31,"unit":"uM","substrate":"L-thyroxine (at pH 6.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}]},{"constant":0.77,"unit":"uM","substrate":"L-thyroxine (at pH 8.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}]},{"constant":71.8,"unit":"uM","substrate":"taurocholate (at pH 5.0)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610227"}]},{"constant":84.0,"unit":"uM","substrate":"substance P/TAC1 (at pH 7.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25132355"}]},{"constant":94.0,"unit":"uM","substrate":"vasoactive intestinal peptide/VIP (at pH 7.5)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25132355"}]},{"constant":0.31,"unit":"uM","substrate":"coproporphyrin III (at pH 7.4)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26383540"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22201122"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.25"}],"value":"Estrone 3-sulfate transport exhibits a biphasic saturation kinetics, with Km and Vmax values of high- and low-affinity sites due to the presence of multiple binding sites."}]}},"phDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12724351"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14610227"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20507927"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22201122"}],"value":"Optimum pH is around 5.0 with estrone 3-sulfate, dehydroepiandrosterone sulfate and taurocholate as substrates (PubMed:12724351, PubMed:14610227, PubMed:20507927, PubMed:22201122). The high-affinity site for estrone 3-sulfate binding is pH-dependent with increased transport at lower pH, while the low-affinity site is pH-independent (PubMed:22201122). Taurocholate is only transported at acidic pH (PubMed:14610227)."}]},"temperatureDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11932330"}],"value":"Optimum temperature is 37 degrees Celsius with estrone 3-sulfate as substrate."}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q96QZ7","geneName":"MAGI1","intActId":"EBI-924464"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q5T2W1","geneName":"PDZK1","intActId":"EBI-349819"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q14160","geneName":"SCRIB","intActId":"EBI-357345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q07157","geneName":"TJP1","intActId":"EBI-79553"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"O94956","intActId":"EBI-61300758"},"interactantTwo":{"uniProtKBAccession":"Q9P202","geneName":"WHRN","intActId":"EBI-310886"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR 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Despite a previous report that demonstrated a pH-dependent substrate uptake and a transport stimulation at low pH (PubMed:14610227), another study did not observe any pH-dependent E1S and taurocholate transport (PubMed:14610227, PubMed:23531488). Was shown to mediate bile acid taurocholate transport at low pH in some studies (PubMed:14610227, PubMed:29871943), but not others (PubMed:11159893, PubMed:23531488, PubMed:29871943). The enterocyte localization of SLCO2B1/OATP2B1 remains uncertain. While some authors found it in the apical membrane (PubMed:12724351), consistent with a function as uptake carrier contributing to the intestinal absorption of drugs, other studies demonstrated a basolateral membrane expression, supporting a physiological role in substrate uptake from the blood flow and intestinal clearance (PubMed:12724351, PubMed:28408210)"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA74903.2","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":709,"modifier":"EXACT"}},"description":"Solute carrier organic anion transporter family member 2B1","featureId":"PRO_0000191061"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Helical; 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