{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9Y6L6","secondaryAccessions":["B2R7G2","Q29R64","Q9NQ37","Q9UBF3","Q9UH89"],"uniProtkbId":"SO1B1_HUMAN","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-12-01","entryVersion":206,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Solute carrier organic anion transporter family member 1B1"},"shortNames":[{"value":"SLCO1B1"}]},"alternativeNames":[{"fullName":{"value":"Liver-specific organic anion transporter 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10358072"}],"value":"LST-1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12196548"}],"value":"OATP-C"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12196548"}],"value":"Organic anion transporter SLC21A6"}},{"fullName":{"value":"Sodium-independent organic anion-transporting polypeptide 2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10601278"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12196548"}],"value":"OATP-2"}]},{"fullName":{"value":"Solute carrier family 21 member 6"}}]},"genes":[{"geneName":{"value":"SLCO1B1"},"synonyms":[{"value":"LST1"},{"value":"OATP1B1"},{"value":"OATP2"},{"value":"OATPC"},{"value":"SLC21A6"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10601278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10873595"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11159893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196548"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12568656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15159445"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15970799"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16624871"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16627748"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17412826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22232210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23243220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26383540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26979622"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35307651"}],"value":"Mediates the Na(+)-independent uptake of organic anions (PubMed:10358072, PubMed:15159445, PubMed:17412826). Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine) (PubMed:10358072, PubMed:10601278, PubMed:10873595, PubMed:11159893, PubMed:12196548, PubMed:12568656, PubMed:15159445, PubMed:15970799, PubMed:16627748, PubMed:17412826, PubMed:19129463, PubMed:26979622). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed:22232210). Involved in the clearance of endogenous and exogenous substrates from the liver (PubMed:10358072, PubMed:10601278). Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs (PubMed:10601278, PubMed:15159445, PubMed:15970799). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drug methotrexate (PubMed:23243220). May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed:16624871, PubMed:16627748). Shows a pH-sensitive substrate specificity towards prostaglandin E2 and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"taurocholate(out) = taurocholate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71703"},{"database":"ChEBI","id":"CHEBI:36257"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10601278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196548"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17412826"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19129463"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 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3,3',5'-triiodo-L-thyronine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71815"},{"database":"ChEBI","id":"CHEBI:57261"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-thyroxine(out) = L-thyroxine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71819"},{"database":"ChEBI","id":"CHEBI:58448"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10601278"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19129463"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"prostaglandin E2(out) = prostaglandin E2(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50984"},{"database":"ChEBI","id":"CHEBI:606564"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10873595"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19129463"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"thromboxane B2(out) = thromboxane B2(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:50992"},{"database":"ChEBI","id":"CHEBI:90696"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72691"},{"database":"ChEBI","id":"CHEBI:82961"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10873595"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196548"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12568656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15159445"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15970799"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16627748"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"leukotriene C4(out) = leukotriene C4(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72743"},{"database":"ChEBI","id":"CHEBI:57973"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"leukotriene E4(out) = leukotriene E4(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72747"},{"database":"ChEBI","id":"CHEBI:57462"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(out) = (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72791"},{"database":"ChEBI","id":"CHEBI:57767"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22232210"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"bilirubin IXalpha bis-beta-D-glucuronoside(out) = bilirubin IXalpha bis-beta-D-glucuronoside(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:72795"},{"database":"ChEBI","id":"CHEBI:58471"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22232210"}]}},{"commentType":"BIOPHYSICOCHEMICAL 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3-sulfate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15159445"}]},{"constant":8.29,"unit":"uM","substrate":"17beta-estradiol 17-O-(beta-D-glucuronate)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15159445"}]},{"constant":1.39,"unit":"uM","substrate":"valsartan","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16624871"}]},{"constant":262.0,"unit":"uM","substrate":"enalapril","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16627748"}]},{"constant":0.13,"unit":"uM","substrate":"coproporphyrin I","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26383540"}]},{"constant":0.22,"unit":"uM","substrate":"coproporphyrin III","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26383540"}]}]},"phDependence":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}],"value":"Optimum pH is 6.5 with prostaglandin E2 and L-thyroxine (T4) as substrates."}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q15700","geneName":"DLG2","intActId":"EBI-80426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q96QZ7","geneName":"MAGI1","intActId":"EBI-924464"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q5T2W1","geneName":"PDZK1","intActId":"EBI-349819"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q07157","geneName":"TJP1","intActId":"EBI-79553"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9Y6L6","intActId":"EBI-21761024"},"interactantTwo":{"uniProtKBAccession":"Q9P202","geneName":"WHRN","intActId":"EBI-310886"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR 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Localized to the basal membrane of Sertoli cells (PubMed:35307651)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196548"}],"value":"Basolateral cell membrane","id":"SL-0026"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196548"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35307651"}],"value":"Basal cell membrane","id":"SL-0024"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10358072"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10601278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10873595"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12196548"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15159445"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22232210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35307651"}],"value":"Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes (PubMed:10358072, PubMed:10601278, PubMed:10873595, PubMed:12196548, PubMed:22232210). Expressed in liver (at protein level) (PubMed:15159445). Expressed in fetal liver (PubMed:10873595). Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte (PubMed:10358072, PubMed:10873595). In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and within the tubules (PubMed:35307651)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"}],"value":"A conserved histidine residue in the third TMD (His-115) may play an essential role in the pH sensitivity of SLCO1B1/OATP1B1-mediated substrate transport"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Hyperbilirubinemia, Rotor type","diseaseAccession":"DI-03360","acronym":"HBLRR","description":"An autosomal recessive form of primary conjugated hyperbilirubinemia. 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Hepatic pigmentation is normal.","diseaseCrossReference":{"database":"MIM","id":"237450"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22232210"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the organo anion transporter (TC 2.A.60) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":691,"modifier":"EXACT"}},"description":"Solute carrier organic anion transporter family member 1B1","featureId":"PRO_0000191050"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Helical; 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