{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P46721","secondaryAccessions":["Q9UGP7","Q9UL38"],"uniProtkbId":"SO1A2_HUMAN","entryAudit":{"firstPublicDate":"1995-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1995-11-01","entryVersion":208,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Solute carrier organic anion transporter family member 1A2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15632119"}],"value":"OATP1A2"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15632119"}],"value":"OATP-A"}},{"fullName":{"value":"Organic anion-transporting polypeptide 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15632119"}],"value":"OATP-1"}]},{"fullName":{"value":"Sodium-independent organic anion transporter"}},{"fullName":{"value":"Solute carrier family 21 member 3"}}]},"genes":[{"geneName":{"value":"SLCO1A2"},"synonyms":[{"value":"OATP"},{"value":"OATP1"},{"value":"OATP1A2"},{"value":"SLC21A3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88397"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q91YY5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11159893"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12568656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17301733"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19129463"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20358049"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20686826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23243220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23918469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25132355"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25560245"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27777271"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7557095"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9539145"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35307651"}],"value":"Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane (PubMed:19129463, PubMed:7557095). Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate) (PubMed:11159893, PubMed:12568656, PubMed:19129463, PubMed:23918469, PubMed:25560245, PubMed:9539145). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision (PubMed:25560245). Involved in the uptake of clinically used drugs (PubMed:17301733, PubMed:20686826, PubMed:27777271). Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (PubMed:19129463, PubMed:20358049). Also transports prostaglandin E2 (PubMed:19129463). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"taurocholate(out) = taurocholate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71703"},{"database":"ChEBI","id":"CHEBI:36257"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7557095"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19129463"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycocholate(out) = glycocholate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71851"},{"database":"ChEBI","id":"CHEBI:29746"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7557095"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"taurochenodeoxycholate(out) = 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3-sulfate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71835"},{"database":"ChEBI","id":"CHEBI:60050"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23918469"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25560245"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19129463"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71815"},{"database":"ChEBI","id":"CHEBI:57261"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20358049"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-thyroxine(out) = L-thyroxine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71819"},{"database":"ChEBI","id":"CHEBI:58448"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20358049"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19129463"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"taurodeoxycholate(out) = taurodeoxycholate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71863"},{"database":"ChEBI","id":"CHEBI:36261"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88397"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycodeoxycholate(out) = glycodeoxycholate(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71867"},{"database":"ChEBI","id":"CHEBI:82982"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O88397"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"glycochenodeoxycholate(out) = 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substrates."}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q02410","geneName":"APBA1","intActId":"EBI-368690"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q99767","geneName":"APBA2","intActId":"EBI-81711"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q12959","geneName":"DLG1","intActId":"EBI-357481"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q15700","geneName":"DLG2","intActId":"EBI-80426"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q92796","geneName":"DLG3","intActId":"EBI-80440"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"P78352","geneName":"DLG4","intActId":"EBI-80389"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q68DX3","geneName":"FRMPD2","intActId":"EBI-53993476"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"A4D2P6","geneName":"GRID2IP","intActId":"EBI-15893226"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q9Y3R0","geneName":"GRIP1","intActId":"EBI-5349621"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q9C0E4","geneName":"GRIP2","intActId":"EBI-949557"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q14005","geneName":"IL16","intActId":"EBI-2831580"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q8N448","geneName":"LNX2","intActId":"EBI-2340947"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q96QZ7","geneName":"MAGI1","intActId":"EBI-924464"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q86UL8","geneName":"MAGI2","intActId":"EBI-311035"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"O75970","geneName":"MPDZ","intActId":"EBI-821405"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q86UT5","geneName":"NHERF4","intActId":"EBI-8744528"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q8NI35","geneName":"PATJ","intActId":"EBI-724390"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q5T2W1","geneName":"PDZK1","intActId":"EBI-349819"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q14160","geneName":"SCRIB","intActId":"EBI-357345"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q07157","geneName":"TJP1","intActId":"EBI-79553"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P46721","intActId":"EBI-2822234"},"interactantTwo":{"uniProtKBAccession":"Q9P202","geneName":"WHRN","intActId":"EBI-310886"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR 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Expressed in brain neurons in both cortex and hippocampus (PubMed:10873595, PubMed:25132355). Expressed in placental trophoblasts (PubMed:12409283). Also expressed in lung and testes at lower levels (PubMed:7557095). Expressed in the eye (at protein level) (PubMed:25560245). Expressed in the retina in the outer and inner nuclear layers, the inner plexiform layer and the ganglion cell layer (PubMed:25132355). Expressed in liver and prostate (PubMed:10873595). In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and within the tubules (PubMed:35307651). Expressed in fetal brain and liver (PubMed:10873595)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19129463"}],"value":"A conserved histidine residue in the third TMD (His-107) may play an essential role in the pH sensitivity of SLCO1A2/OATP1A2-mediated substrate transport"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the organo anion transporter (TC 2.A.60) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":670,"modifier":"EXACT"}},"description":"Solute carrier organic anion transporter family member 1A2","featureId":"PRO_0000191042"},{"type":"Topological 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