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Inhibited by natural product phlorizin and diabetic drugs, including empagliflozin and dapagliflozin, canagliflozin, and sotagliflozin (PubMed:20980548, PubMed:28592437, PubMed:38057552). Empagliflozin is selective for SLC5A2/SGLT2 over SLC5A1/SGLT1 and it inhibits by occupying the sugar-binding site in SLC5A2 (PubMed:34880493)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34880493"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37217492"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38057552"}],"value":"Forms a heterodimer (via TM13) with PDZK1IP1 (via N-terminal transmembrane helix); this interaction enhances SLC5A2 transporter 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