{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q05940","secondaryAccessions":["B2RC96","D3DRC4","Q15876","Q4G147","Q5VW49","Q9H3P6"],"uniProtkbId":"VMAT2_HUMAN","entryAudit":{"firstPublicDate":"1994-10-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-10-01","entryVersion":212,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Synaptic vesicular amine transporter"}},"alternativeNames":[{"fullName":{"value":"Solute carrier family 18 member 2"}},{"fullName":{"value":"Vesicular amine transporter 2"},"shortNames":[{"value":"VAT2"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"38517752"}],"value":"Vesicular monoamine transporter 2"}}]},"genes":[{"geneName":{"value":"SLC18A2"},"synonyms":[{"value":"SVMT"},{"value":"VMAT2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q01827"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BRU6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23363473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8643547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8860238"}],"value":"Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:23363473, PubMed:37914936, PubMed:38081299, PubMed:38517752, PubMed:8643547). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed:8860238)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"serotonin(in) + 2 H(+)(out) = serotonin(out) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73743"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23363473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8643547"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:73744"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23363473"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73739"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:59905"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:73740"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"37914936"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"histamine(in) + 2 H(+)(out) = histamine(out) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73755"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:58432"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8860238"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:73756"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"8860238"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8643547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8860238"}],"value":"Strongly inhibited by reserpine and tetrabenazine (PubMed:37914936, PubMed:38081299, PubMed:38517752, PubMed:8643547, PubMed:8860238). Also inhibited to a lesser extent by ketanserin and fenfluramine (PubMed:38081299). Reserpine and ketanserin inhibit by blocking the substrate-binding pocket (PubMed:37914936, PubMed:38081299). Tetrabenazine traps SLC18A2/VMAT2 in an occluded conformation and its inhibition is specific to SLC18A2/VMAT2 but not SLC18A1/VMAT1 (PubMed:37914936, PubMed:38081299, PubMed:38517752)"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":0.8,"unit":"uM","substrate":"serotonin","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8643547"}]},{"constant":300.0,"unit":"uM","substrate":"histamine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8860238"}]}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BRU6"}],"value":"Interacts with SLC6A3"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"Q6PL45-2","geneName":"BRICD5","intActId":"EBI-12244618"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"Q9BXR6","geneName":"CFHR5","intActId":"EBI-11579371"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"Q96DZ9-2","geneName":"CMTM5","intActId":"EBI-11522780"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"P25025","geneName":"CXCR2","intActId":"EBI-2835281"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"Q8TDV0","geneName":"GPR151","intActId":"EBI-11955647"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"Q6N075","geneName":"MFSD5","intActId":"EBI-3920969"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"Q16617","geneName":"NKG7","intActId":"EBI-3919611"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"P30825","geneName":"SLC7A1","intActId":"EBI-4289564"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"Q9BVC6","geneName":"TMEM109","intActId":"EBI-1057733"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q05940","intActId":"EBI-18036244"},"interactantTwo":{"uniProtKBAccession":"Q96B49","geneName":"TOMM6","intActId":"EBI-10826510"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q01827"}],"value":"Sorted to large dense core granules in neuroendocrine cells, presumably at the level of the trans-Golgi network. In neurons it is predominantly detected in somatodendritic tubulovesicular membranes, a distinct population of secretory vesicles that undergo calcium-dependent exocytosis in axons and dendrites upon depolarization. Localized at synaptic vesicles in axons"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q01827"}],"value":"Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane","id":"SL-0260"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q01827"}],"value":"Cytoplasmic vesicle, secretory vesicle membrane","id":"SL-0245"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q01827"}],"value":"Cell projection, axon","id":"SL-0279"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q01827"}],"value":"Cell projection, dendrite","id":"SL-0283"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q05940-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q05940-2"],"sequenceIds":["VSP_057151","VSP_057152"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8643547"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8860238"}],"value":"Expressed in neuronal and neuroendocrine tissues. Detected in central and peripheral nervous system in particular in axonal and dendritic processes in dopaminergic cells of substantia nigra, histaminergic neuronal cell bodies of substantia nigra and tuberomammillary nucleus, in ganglion cells of sympathetic glia and in peripheral sympathetic nerve terminals in stomach and duodenum (at protein level). Highly expressed in chromaffin cells of the adrenal medulla and histamine-storing enterochromaffin-like cells of oxyntic mucosa (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Parkinsonism-dystonia 2, infantile-onset","diseaseAccession":"DI-05288","acronym":"PKDYS2","description":"An autosomal recessive disorder characterized by infantile onset of abnormal movements, including parkinsonism, dystonia, and poor fine motor skills, as well as autonomic dysfunction, including abnormal sweating, cold extremities, and poor sleep. Some patients have variable degrees of developmental delay.","diseaseCrossReference":{"database":"MIM","id":"618049"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23363473"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the major facilitator superfamily. Vesicular transporter family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"BAB19009.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter","ftp":false,"note":"Vesicular monoamine transporter entry"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"Synaptic vesicular amine transporter","featureId":"PRO_0000127514"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Lumenal, vesicle","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Lumenal, vesicle","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Lumenal, vesicle","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Lumenal, vesicle","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":353,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":389,"modifier":"EXACT"}},"description":"Lumenal, vesicle","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":415,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":436,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"Lumenal, vesicle","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Transmembrane","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Topological domain","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"type":"Binding site","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"ligand":{"name":"serotonin","id":"ChEBI:CHEBI:350546"}},{"type":"Binding site","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"ligand":{"name":"serotonin","id":"ChEBI:CHEBI:350546"}},{"type":"Binding site","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"}],"ligand":{"name":"serotonin","id":"ChEBI:CHEBI:350546"}},{"type":"Binding site","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"ligand":{"name":"serotonin","id":"ChEBI:CHEBI:350546"}},{"type":"Binding site","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"}],"ligand":{"name":"serotonin","id":"ChEBI:CHEBI:350546"}},{"type":"Binding site","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"}],"ligand":{"name":"serotonin","id":"ChEBI:CHEBI:350546"}},{"type":"Binding site","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"ligand":{"name":"serotonin","id":"ChEBI:CHEBI:350546"}},{"type":"Binding site","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"ligand":{"name":"serotonin","id":"ChEBI:CHEBI:350546"}},{"type":"Binding site","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"}],"ligand":{"name":"serotonin","id":"ChEBI:CHEBI:350546"}},{"type":"Modified residue","location":{"start":{"value":511,"modifier":"EXACT"},"end":{"value":511,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q01827"}]},{"type":"Modified residue","location":{"start":{"value":513,"modifier":"EXACT"},"end":{"value":513,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q01827"}]},{"type":"Glycosylation","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12009896"}]},{"type":"Alternative sequence","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_057151","alternativeSequence":{"originalSequence":"MGMLAS","alternativeSequences":["RCGMPE"]}},{"type":"Alternative sequence","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":514,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_057152","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":387,"modifier":"EXACT"}},"description":"in PKDYS2; strong decrease in serotonin transport; dbSNP:rs1392638187","featureCrossReferences":[{"database":"dbSNP","id":"rs1392638187"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23363473"}],"featureId":"VAR_081069","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake.","alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Abolishes binding to reserpine. Reduces binding to dihydrotetrabenazine. Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Reduces binding to dihydrotetrabenazine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}},{"type":"Mutagenesis","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Reduces sensitivity to tetrabenazine. Reduces fluorescent false neurotransmitter FFN206 uptake. Abolishes binding to dihydrotetrabenazine. Abolishes serotonin uptake. Largely reduces sensitivity to tetrabenazine and slightly reduces FFN206 uptake; when associated with V-308 and F-433.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Abolishes binding to tetrabenazine. Reduces sensitivity to tetrabenazine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["Y"]}},{"type":"Mutagenesis","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Reduces dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Reduces sensitivity to tetrabenazine. Abolishes FFN206 uptake. Abolishes binding to dihydrotetrabenazine. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Reduces dopamine uptake. Abolishes binding to dihydrotetrabenazine. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Abolishes binding to tetrabenazine. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Mutagenesis","location":{"start":{"value":189,"modifier":"EXACT"},"end":{"value":189,"modifier":"EXACT"}},"description":"Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Reduces dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Reduces dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"Abolishes serotonin uptake; when associated with A-217.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"Reduces dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake. Abolishes serotonin uptake; when associated with A-214.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"Reduces dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":225,"modifier":"EXACT"}},"description":"Reduces binding to reserpine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Reduces sensitivity to reserpine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Abolishes binding to reserpine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Abolishes serotonin uptake. Abolishes binding to tetrabenazine. Reduces sensitivity to reserpine and tetrabenazine. Reduces binding to dihydrotetrabenazine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Mutagenesis","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Abolishes dopamine uptake. Reduces FFN206 uptake. Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Reduces sensitivity to tetrabenazine. Largely reduces sensitivity to tetrabenazine and slightly reduces FFN206 uptake; when associated with F-37 and F-433.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Abolishes dopamine uptake. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake. Abolishes serotonin uptake. Reduces binding to dihydrotetrabenazine. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Abolishes dopamine uptake. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Reduces binding to dihydrotetrabenazine. Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Reduces binding to dihydrotetrabenazine. Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["H"]}},{"type":"Mutagenesis","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":334,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Reduces binding to reserpine. Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Reduces dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Abolishes serotonin uptake. Abolishes binding to reserpine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A","N"]}},{"type":"Mutagenesis","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"Reduces binding to dihydrotetrabenazine. Reduces binding to reserpine. Abolishes dopamine uptake. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Mutagenesis","location":{"start":{"value":395,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"Reduces binding to reserpine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A","N"]}},{"type":"Mutagenesis","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Reduces binding to reserpine. Reduces dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Reduces dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Reduces dopamine uptake. Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":418,"modifier":"EXACT"}},"description":"Binds reserpine in the absence of a proton gradient. Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"Reduces dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"Abolishes dopamine uptake. Abolishes serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"Abolishes binding to reserpine. Reduces serotonin uptake.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Abolishes binding to dihydrotetrabenazine. Slightly reduces binding to reserpine and FFN206 uptake. Reduces dopamine uptake. Reduces sensitivity to tetrabenazine.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38517752"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":433,"modifier":"EXACT"},"end":{"value":433,"modifier":"EXACT"}},"description":"Slightly reduces sensitivity to tetrabenazine and FFN206 uptake. Reduces serotonin uptake. Reduces sensitivity to reserpine. Largely reduces sensitivity to tetrabenazine and slightly reduces FFN206 uptake; when associated with F-37 and V-308.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37914936"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38081299"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"in Ref. 4; CAA50489","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"in Ref. 1; AAA59877","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":354,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"in Ref. 1; AAA59877","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"in Ref. 1; AAA59877","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":395,"modifier":"EXACT"},"end":{"value":395,"modifier":"EXACT"}},"description":"in Ref. 1; AAA59877","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Helix","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8WRE"}]},{"type":"Helix","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Turn","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8THR"}]},{"type":"Helix","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8THR"}]},{"type":"Helix","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8XO9"}]},{"type":"Helix","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8T69"}]},{"type":"Helix","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":292,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":332,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":335,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":464,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8JSW"}]},{"type":"Helix","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":475,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8THR"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-1023","category":"Disease","name":"Dystonia"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0532","category":"Biological process","name":"Neurotransmitter transport"},{"id":"KW-0908","category":"Disease","name":"Parkinsonism"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"8095030","citationType":"journal article","authors":["Surratt C.K.","Persico A.M.","Yang X.D.","Edgar S.R.","Bird G.S.","Hawkins A.L.","Griffin C.A.","Li X.","Jabs E.W.","Uhl G.R."],"citationCrossReferences":[{"database":"PubMed","id":"8095030"},{"database":"DOI","id":"10.1016/0014-5793(93)80539-7"}],"title":"A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs.","publicationDate":"1993","journal":"FEBS Lett.","firstPage":"325","lastPage":"330","volume":"318"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"8245983","citationType":"journal article","authors":["Erickson J.D.","Eiden L.E."],"citationCrossReferences":[{"database":"PubMed","id":"8245983"},{"database":"DOI","id":"10.1111/j.1471-4159.1993.tb07476.x"}],"title":"Functional identification and molecular cloning of a human brain vesicle monoamine transporter.","publicationDate":"1993","journal":"J. Neurochem.","firstPage":"2314","lastPage":"2317","volume":"61"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"7905859","citationType":"journal article","authors":["Peter D.","Finn J.P.","Klisak I.","Liu Y.","Kojis T.","Heinzmann C.","Roghani A.","Sparkes R.S.","Edwards R.H."],"citationCrossReferences":[{"database":"PubMed","id":"7905859"},{"database":"DOI","id":"10.1016/s0888-7543(05)80383-0"}],"title":"Chromosomal localization of the human vesicular amine transporter genes.","publicationDate":"1993","journal":"Genomics","firstPage":"720","lastPage":"723","volume":"18"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Substantia nigra","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"8373557","citationType":"journal article","authors":["Lesch K.P.","Gross J.","Wolozin B.L.","Murphy D.L.","Riederer P."],"citationCrossReferences":[{"database":"PubMed","id":"8373557"},{"database":"DOI","id":"10.1007/bf01244941"}],"title":"Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: possible molecular basis for species differences in the susceptibility to MPP+.","publicationDate":"1993","journal":"J. Neural Transm.","firstPage":"75","lastPage":"82","volume":"93"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"11443533","citationType":"journal article","authors":["Kunugi H.","Ishida S.","Akahane A.","Nanko S."],"citationCrossReferences":[{"database":"PubMed","id":"11443533"},{"database":"DOI","id":"10.1038/sj.mp.4000895"}],"title":"Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene.","publicationDate":"2001","journal":"Mol. Psychiatry","firstPage":"456","lastPage":"460","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.R.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.S.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.M.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":8,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":9,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"]},{"referenceNumber":10,"citation":{"id":"8860238","citationType":"journal article","authors":["Erickson J.D.","Eiden L.E.","Schafer M.K.","Weihe E."],"citationCrossReferences":[{"database":"PubMed","id":"8860238"},{"database":"DOI","id":"10.1007/bf02736786"}],"title":"Reserpine- and tetrabenazine-sensitive transport of (3)H-histamine by the neuronal isoform of the vesicular monoamine transporter.","publicationDate":"1995","journal":"J. Mol. Neurosci.","firstPage":"277","lastPage":"287","volume":"6"},"referencePositions":["FUNCTION","TRANSPORT ACTIVITY","ACTIVITY REGULATION","TISSUE SPECIFICITY"]},{"referenceNumber":11,"citation":{"id":"8643547","citationType":"journal article","authors":["Erickson J.D.","Schaefer M.K.-H.","Bonner T.I.","Eiden L.E.","Weihe E."],"citationCrossReferences":[{"database":"PubMed","id":"8643547"},{"database":"DOI","id":"10.1073/pnas.93.10.5166"}],"title":"Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.","publicationDate":"1996","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"5166","lastPage":"5171","volume":"93"},"referencePositions":["FUNCTION","TRANSPORT ACTIVITY","BIOPHYSICOCHEMICAL PROPERTIES","ACTIVITY REGULATION","TISSUE SPECIFICITY"]},{"referenceNumber":12,"citation":{"id":"12009896","citationType":"journal article","authors":["Thiriot D.S.","Sievert M.K.","Ruoho A.E."],"citationCrossReferences":[{"database":"PubMed","id":"12009896"},{"database":"DOI","id":"10.1021/bi015779j"}],"title":"Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond.","publicationDate":"2002","journal":"Biochemistry","firstPage":"6346","lastPage":"6353","volume":"41"},"referencePositions":["DISULFIDE BOND"]},{"referenceNumber":13,"citation":{"id":"18088087","citationType":"journal article","authors":["Zahedi R.P.","Lewandrowski U.","Wiesner J.","Wortelkamp S.","Moebius J.","Schuetz C.","Walter U.","Gambaryan S.","Sickmann A."],"citationCrossReferences":[{"database":"PubMed","id":"18088087"},{"database":"DOI","id":"10.1021/pr0704130"}],"title":"Phosphoproteome of resting human platelets.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"526","lastPage":"534","volume":"7"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Platelet","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"23363473","citationType":"journal article","authors":["Rilstone J.J.","Alkhater R.A.","Minassian B.A."],"citationCrossReferences":[{"database":"PubMed","id":"23363473"},{"database":"DOI","id":"10.1056/nejmoa1207281"}],"title":"Brain dopamine-serotonin vesicular transport disease and its treatment.","publicationDate":"2013","journal":"N. Engl. J. Med.","firstPage":"543","lastPage":"550","volume":"368"},"referencePositions":["INVOLVEMENT IN PKDYS2","VARIANT PKDYS2 LEU-387","FUNCTION","TRANSPORT ACTIVITY","BIOPHYSICOCHEMICAL PROPERTIES","CHARACTERIZATION OF VARIANT PKDYS2 LEU-387"]},{"referenceNumber":15,"citation":{"id":"37914936","citationType":"journal article","authors":["Pidathala S.","Liao S.","Dai Y.","Li X.","Long C.","Chang C.L.","Zhang Z.","Lee C.H."],"citationCrossReferences":[{"database":"PubMed","id":"37914936"},{"database":"DOI","id":"10.1038/s41586-023-06727-9"}],"title":"Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2.","publicationDate":"2023","journal":"Nature","firstPage":"1086","lastPage":"1092","volume":"623"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.89 ANGSTROMS) OF 19-514 OF WILD-TYPE AND MUTANT SER-418 IN COMPLEX WITH TETRABENAZINE; SEROTONIN AND RESERPINE","FUNCTION","CATALYTIC ACTIVITY","ACTIVITY REGULATION","INTERACTION WITH SEROTONIN","MUTAGENESIS OF ASP-33; ASN-34; LEU-37; THR-38; VAL-41; PRO-45; PHE-135; LYS-138; ARG-189; SER-196; MET-204; ASP-214; ARG-217; MET-221; LEU-225; VAL-232; ILE-308; GLU-312; PRO-313; PRO-316; TRP-318; PHE-334; SER-338; TYR-341; ARG-357; ILE-395; ASP-399; MET-403; ASP-411; TYR-418; TYR-422; ASP-426; PHE-429 AND TYR-433"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T69"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6A"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8T6B"}]},{"referenceNumber":16,"citation":{"id":"38517752","citationType":"journal article","authors":["Dalton M.P.","Cheng M.H.","Bahar I.","Coleman J.A."],"citationCrossReferences":[{"database":"PubMed","id":"38517752"},{"database":"DOI","id":"10.7554/elife.91973"}],"title":"Structural mechanisms for VMAT2 inhibition by tetrabenazine.","publicationDate":"2024","journal":"Elife","firstPage":"0","lastPage":"0","volume":"12"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.12 ANGSTROMS) OF 12-483 IN COMPLEX WITH TETRABENAZINE","FUNCTION","CATALYTIC ACTIVITY","ACTIVITY REGULATION","MUTAGENESIS OF ASN-34; LEU-37; GLU-127; PHE-135; LYS-138; ARG-189; VAL-232; GLU-312; TRP-318; PHE-429 AND TYR-433"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8THR"}]},{"referenceNumber":17,"citation":{"id":"38081299","citationType":"journal article","authors":["Wu D.","Chen Q.","Yu Z.","Huang B.","Zhao J.","Wang Y.","Su J.","Zhou F.","Yan R.","Li N.","Zhao Y.","Jiang D."],"citationCrossReferences":[{"database":"PubMed","id":"38081299"},{"database":"DOI","id":"10.1038/s41586-023-06926-4"}],"title":"Transport and inhibition mechanisms of human VMAT2.","publicationDate":"2024","journal":"Nature","firstPage":"427","lastPage":"434","volume":"626"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.84 ANGSTROMS) OF 18-474 IN COMPLEX WITH TETRABENAZINE; SEROTONIN; KETANSERIN AND RESERPINE","FUNCTION","CATALYTIC ACTIVITY","ACTIVITY REGULATION","INTERACTION WITH SEROTONIN","MUTAGENESIS OF ASP-33; LEU-37; ARG-189; ASP-214; ARG-217; LEU-228; VAL-232; GLU-244; ASN-305; ILE-308; GLU-312; SER-338; ILE-339; TYR-341; ARG-357; ASP-411; ASP-426 AND TYR-433"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JSW"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JT9"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTA"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8JTC"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L09118","properties":[{"key":"ProteinId","value":"AAA59877.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L23205","properties":[{"key":"ProteinId","value":"AAA61290.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"L14269","properties":[{"key":"ProteinId","value":"AAA91853.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X71354","properties":[{"key":"ProteinId","value":"CAA50489.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB044401","properties":[{"key":"ProteinId","value":"BAB19009.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK314997","properties":[{"key":"ProteinId","value":"BAG37493.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL391988","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL731557","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471066","properties":[{"key":"ProteinId","value":"EAW49428.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471066","properties":[{"key":"ProteinId","value":"EAW49429.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC030593","properties":[{"key":"ProteinId","value":"AAH30593.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC108927","properties":[{"key":"ProteinId","value":"AAI08928.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC108928","properties":[{"key":"ProteinId","value":"AAI08929.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS7599.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q05940-1"},{"database":"PIR","id":"A49368","properties":[{"key":"EntryName","value":"A49368"}]},{"database":"PIR","id":"S29810","properties":[{"key":"EntryName","value":"S29810"}]},{"database":"RefSeq","id":"NP_003045.2","properties":[{"key":"NucleotideSequenceId","value":"NM_003054.6"}],"isoformId":"Q05940-1"},{"database":"PDB","id":"8JSW","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.84 A"},{"key":"Chains","value":"A=18-474"}]},{"database":"PDB","id":"8JSX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.16 A"},{"key":"Chains","value":"A=18-474"}]},{"database":"PDB","id":"8JT5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.06 A"},{"key":"Chains","value":"A=18-474"}]},{"database":"PDB","id":"8JT9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.97 A"},{"key":"Chains","value":"A=18-474"}]},{"database":"PDB","id":"8JTA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.36 A"},{"key":"Chains","value":"A=18-474"}]},{"database":"PDB","id":"8JTB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.93 A"},{"key":"Chains","value":"A=18-474"}]},{"database":"PDB","id":"8JTC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.52 A"},{"key":"Chains","value":"A=18-474"}]},{"database":"PDB","id":"8T69","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.89 A"},{"key":"Chains","value":"A=19-514"}]},{"database":"PDB","id":"8T6A","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.17 A"},{"key":"Chains","value":"A=19-514"}]},{"database":"PDB","id":"8T6B","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.72 A"},{"key":"Chains","value":"A=19-514"}]},{"database":"PDB","id":"8THR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.12 A"},{"key":"Chains","value":"A=12-483"}]},{"database":"PDB","id":"8UCJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8UCK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.26 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8UCL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.18 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8UCM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.14 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8UCN","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.31 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8UCO","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.25 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8UCP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.28 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8WLJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"A=1-474"}]},{"database":"PDB","id":"8WLK","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.37 A"},{"key":"Chains","value":"A=1-474"}]},{"database":"PDB","id":"8WLL","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.74 A"},{"key":"Chains","value":"A=1-474"}]},{"database":"PDB","id":"8WLM","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.57 A"},{"key":"Chains","value":"A=1-474"}]},{"database":"PDB","id":"8WRD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.05 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8WRE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8WVG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.18 A"},{"key":"Chains","value":"A=1-514"}]},{"database":"PDB","id":"8X3K","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.98 A"},{"key":"Chains","value":"A=12-514"}]},{"database":"PDB","id":"8XO9","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A=17-474"}]},{"database":"PDB","id":"8XOA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.03 A"},{"key":"Chains","value":"A=18-474"}]},{"database":"PDB","id":"8XOB","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.15 A"},{"key":"Chains","value":"A=18-474"}]},{"database":"PDB","id":"9KQ8","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.38 A"},{"key":"Chains","value":"A=12-514"}]},{"database":"PDB","id":"9KQA","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.28 A"},{"key":"Chains","value":"A=12-514"}]},{"database":"PDB","id":"9KQE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A=12-514"}]},{"database":"PDBsum","id":"8JSW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JSX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JT5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JT9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JTA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JTB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8JTC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8T69","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8T6A","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8T6B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8THR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UCJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UCK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UCL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UCM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UCN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UCO","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8UCP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WLJ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WLK","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WLL","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WLM","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WRD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WRE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8WVG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8X3K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XO9","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XOA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8XOB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KQ8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KQA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KQE","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36628","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36629","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36633","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36637","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36638","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36639","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-36640","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37621","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37622","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37623","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37624","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37774","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37775","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37867","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38038","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38523","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38524","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-38525","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-41066","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-41067","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-41068","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-41269","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42128","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42129","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42130","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42131","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42132","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42133","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-42134","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62497","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62498","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-62501","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112459","properties":[{"key":"Interactions","value":"137"}]},{"database":"CORUM","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q05940","properties":[{"key":"Number of interactors","value":"388"}]},{"database":"IntAct","id":"Q05940","properties":[{"key":"Interactions","value":"158"}]},{"database":"NDEx","id":"IQUERY-CP-SLC18A2","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000496339","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL1893","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB01472","properties":[{"key":"GenericName","value":"4-Methoxyamphetamine"}]},{"database":"DrugBank","id":"DB00182","properties":[{"key":"GenericName","value":"Amphetamine"}]},{"database":"DrugBank","id":"DB00714","properties":[{"key":"GenericName","value":"Apomorphine"}]},{"database":"DrugBank","id":"DB00865","properties":[{"key":"GenericName","value":"Benzphetamine"}]},{"database":"DrugBank","id":"DB01089","properties":[{"key":"GenericName","value":"Deserpidine"}]},{"database":"DrugBank","id":"DB12161","properties":[{"key":"GenericName","value":"Deutetrabenazine"}]},{"database":"DrugBank","id":"DB01576","properties":[{"key":"GenericName","value":"Dextroamphetamine"}]},{"database":"DrugBank","id":"DB00988","properties":[{"key":"GenericName","value":"Dopamine"}]},{"database":"DrugBank","id":"DB01363","properties":[{"key":"GenericName","value":"Ephedra sinica root"}]},{"database":"DrugBank","id":"DB01364","properties":[{"key":"GenericName","value":"Ephedrine"}]},{"database":"DrugBank","id":"DB12010","properties":[{"key":"GenericName","value":"Fostamatinib"}]},{"database":"DrugBank","id":"DB00502","properties":[{"key":"GenericName","value":"Haloperidol"}]},{"database":"DrugBank","id":"DB05381","properties":[{"key":"GenericName","value":"Histamine"}]},{"database":"DrugBank","id":"DB06706","properties":[{"key":"GenericName","value":"Isometheptene"}]},{"database":"DrugBank","id":"DB05137","properties":[{"key":"GenericName","value":"Lobeline"}]},{"database":"DrugBank","id":"DB00579","properties":[{"key":"GenericName","value":"Mazindol"}]},{"database":"DrugBank","id":"DB01577","properties":[{"key":"GenericName","value":"Metamfetamine"}]},{"database":"DrugBank","id":"DB01454","properties":[{"key":"GenericName","value":"Midomafetamine"}]},{"database":"DrugBank","id":"DB01442","properties":[{"key":"GenericName","value":"MMDA"}]},{"database":"DrugBank","id":"DB04821","properties":[{"key":"GenericName","value":"Nomifensine"}]},{"database":"DrugBank","id":"DB00368","properties":[{"key":"GenericName","value":"Norepinephrine"}]},{"database":"DrugBank","id":"DB06714","properties":[{"key":"GenericName","value":"Propylhexedrine"}]},{"database":"DrugBank","id":"DB09363","properties":[{"key":"GenericName","value":"Rauwolfia serpentina root"}]},{"database":"DrugBank","id":"DB00206","properties":[{"key":"GenericName","value":"Reserpine"}]},{"database":"DrugBank","id":"DB08839","properties":[{"key":"GenericName","value":"Serotonin"}]},{"database":"DrugBank","id":"DB04844","properties":[{"key":"GenericName","value":"Tetrabenazine"}]},{"database":"DrugBank","id":"DB11915","properties":[{"key":"GenericName","value":"Valbenazine"}]},{"database":"DrugCentral","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"1012","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"2.A.1.2.29","properties":[{"key":"FamilyName","value":"the major facilitator superfamily (mfs)"}]},{"database":"GlyCosmos","id":"Q05940","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q05940","properties":[{"key":"glycosylation","value":"2 sites"}]},{"database":"iPTMnet","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"SLC18A2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"1722742","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000496339","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"58362","properties":[{"key":"Description","value":"-"}],"isoformId":"Q05940-1"},{"database":"ABCD","id":"Q05940","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"2802","properties":[{"key":"antibodies","value":"420 antibodies from 38 providers"}]},{"database":"DNASU","id":"6571","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000644641.2","properties":[{"key":"ProteinId","value":"ENSP00000496339.1"},{"key":"GeneId","value":"ENSG00000165646.15"}],"isoformId":"Q05940-1"},{"database":"Ensembl","id":"ENST00000921156.1","properties":[{"key":"ProteinId","value":"ENSP00000591215.1"},{"key":"GeneId","value":"ENSG00000165646.15"}],"isoformId":"Q05940-1"},{"database":"Ensembl","id":"ENST00000956273.1","properties":[{"key":"ProteinId","value":"ENSP00000626332.1"},{"key":"GeneId","value":"ENSG00000165646.15"}],"isoformId":"Q05940-1"},{"database":"GeneID","id":"6571","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6571","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000644641.2","properties":[{"key":"ProteinId","value":"ENSP00000496339.1"},{"key":"RefSeqNucleotideId","value":"NM_003054.6"},{"key":"RefSeqProteinId","value":"NP_003045.2"}]},{"database":"UCSC","id":"uc001ldd.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q05940-1"},{"database":"AGR","id":"HGNC:10935","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA325","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6571","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6571","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"SLC18A2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10935","properties":[{"key":"GeneName","value":"SLC18A2"}]},{"database":"HPA","id":"ENSG00000165646","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain, cervix)"}]},{"database":"MalaCards","id":"SLC18A2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"193001","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"618049","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000165646","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"352649","properties":[{"key":"Disease","value":"Brain dopamine-serotonin vesicular transport disease"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000165646","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3764","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157593","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001265_10_9_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"IVAPLWG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5086884at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q05940","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-181429","properties":[{"key":"PathwayName","value":"Serotonin Neurotransmitter Release Cycle"}]},{"database":"Reactome","id":"R-HSA-181430","properties":[{"key":"PathwayName","value":"Norepinephrine Neurotransmitter Release Cycle"}]},{"database":"Reactome","id":"R-HSA-212676","properties":[{"key":"PathwayName","value":"Dopamine Neurotransmitter Release Cycle"}]},{"database":"SignaLink","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000165646","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6571","properties":[{"key":"hits","value":"12 hits in 1163 CRISPR screens"}]},{"database":"ChiTaRS","id":"SLC18A2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"Vesicular_monoamine_transporter_2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6571","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q05940","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:Q05940","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"RNAct","id":"Q05940","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000165646","properties":[{"key":"ExpressionPatterns","value":"Expressed in substantia nigra pars reticulata and 123 other cell types or tissues"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070083","properties":[{"key":"GoTerm","value":"C:clathrin-sculpted monoamine transport vesicle membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030425","properties":[{"key":"GoTerm","value":"C:dendrite"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098691","properties":[{"key":"GoTerm","value":"C:dopaminergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"TAS:ProtInc"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"8095030"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0030667","properties":[{"key":"GoTerm","value":"C:secretory granule membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008021","properties":[{"key":"GoTerm","value":"C:synaptic vesicle"},{"key":"GoEvidenceType","value":"TAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21563316"}]},{"database":"GO","id":"GO:0030672","properties":[{"key":"GoTerm","value":"C:synaptic vesicle membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043195","properties":[{"key":"GoTerm","value":"C:terminal bouton"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0008504","properties":[{"key":"GoTerm","value":"F:monoamine transmembrane transporter activity"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0015311","properties":[{"key":"GoTerm","value":"F:monoamine:proton antiporter activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23363473"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8643547"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8860238"}]},{"database":"GO","id":"GO:0005335","properties":[{"key":"GoTerm","value":"F:serotonin:sodium:chloride symporter activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0015842","properties":[{"key":"GoTerm","value":"P:aminergic neurotransmitter loading into synaptic vesicle"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007268","properties":[{"key":"GoTerm","value":"P:chemical synaptic transmission"},{"key":"GoEvidenceType","value":"TAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"15217342"}]},{"database":"GO","id":"GO:0002553","properties":[{"key":"GoTerm","value":"P:histamine secretion by mast cell"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051615","properties":[{"key":"GoTerm","value":"P:histamine uptake"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8860238"}]},{"database":"GO","id":"GO:1903427","properties":[{"key":"GoTerm","value":"P:negative regulation of reactive oxygen species biosynthetic process"},{"key":"GoEvidenceType","value":"NAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24252804"}]},{"database":"GO","id":"GO:0098700","properties":[{"key":"GoTerm","value":"P:neurotransmitter loading into synaptic vesicle"},{"key":"GoEvidenceType","value":"TAS:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"21563316"}]},{"database":"GO","id":"GO:0006836","properties":[{"key":"GoTerm","value":"P:neurotransmitter transport"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0002552","properties":[{"key":"GoTerm","value":"P:serotonin secretion by mast cell"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0051610","properties":[{"key":"GoTerm","value":"P:serotonin uptake"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23363473"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"8643547"}]},{"database":"GO","id":"GO:0099123","properties":[{"key":"GoTerm","value":"P:somato-dendritic dopamine secretion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd17384","properties":[{"key":"EntryName","value":"MFS_SLC18A1_2_VAT1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000083","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000116","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"InterPro","id":"IPR050930","properties":[{"key":"EntryName","value":"MFS_Vesicular_Transporter"}]},{"database":"PANTHER","id":"PTHR23506","properties":[{"key":"EntryName","value":"GH10249P"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23506:SF30","properties":[{"key":"EntryName","value":"SYNAPTIC VESICULAR AMINE TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD","length":514,"molWeight":55713,"crc64":"42EA91A225485DB2","md5":"B33E7B1A814BAC39E4DDFE9F6C59D10B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":3,"ACTIVITY REGULATION":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBUNIT":1,"INTERACTION":10,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Topological domain":13,"Transmembrane":12,"Binding site":9,"Modified residue":2,"Glycosylation":2,"Disulfide bond":1,"Alternative sequence":2,"Natural variant":1,"Mutagenesis":61,"Sequence conflict":5,"Helix":21,"Turn":1},"uniParcId":"UPI00001389DE"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8PHI4","uniProtkbId":"A0ACI8PHI4_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523737.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523737.1"}],"value":"Solute carrier family 18 member A2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523737.1"}],"value":"SLC18A2"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73739"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:59905"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034439"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:73740"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034439"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"serotonin(in) + 2 H(+)(out) = serotonin(out) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73743"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048115"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:73744"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048115"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane","id":"SL-0260"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006829"}],"value":"Belongs to the major facilitator superfamily. Vesicular transporter family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":217,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":299,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":326,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":443,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022775"}],"id":"KW-0532","category":"Biological process","name":"Neurotransmitter transport"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8PHI4"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8PHI4"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523737.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523737.1"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523737.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523737.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL391988","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL731557","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000853678.1","properties":[{"key":"ProteinId","value":"ENSP00000523737.1"},{"key":"GeneId","value":"ENSG00000165646.15"}]},{"database":"HGNC","id":"HGNC:10935","properties":[{"key":"GeneName","value":"SLC18A2"}]},{"database":"OpenTargets","id":"ENSG00000165646","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157593","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"CDD","id":"cd17384","properties":[{"key":"EntryName","value":"MFS_SLC18A1_2_VAT1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000083","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000116","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"InterPro","id":"IPR050930","properties":[{"key":"EntryName","value":"MFS_Vesicular_Transporter"}]},{"database":"InterPro","id":"IPR001958","properties":[{"key":"EntryName","value":"Tet-R_TetA/multi-R_MdtG-like"}]},{"database":"NCBIfam","id":"TIGR00880","properties":[{"key":"EntryName","value":"2_A_01_02"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23506","properties":[{"key":"EntryName","value":"GH10249P"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23506:SF30","properties":[{"key":"EntryName","value":"SYNAPTIC VESICULAR AMINE TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD","length":482,"molWeight":52166,"crc64":"0E8E3043D58171E8","md5":"1C516219BA4228AC4FC6E78390C7296F"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":11,"Domain":1},"uniParcId":"UPI004031EE92"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T2M1","uniProtkbId":"A0ACI8T2M1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591217.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591217.1"}],"value":"Solute carrier family 18 member A2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591217.1"}],"value":"SLC18A2"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane","id":"SL-0260"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":332,"modifier":"EXACT"},"end":{"value":352,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":456,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T2M1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T2M1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591217.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591217.1"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591217.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591217.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL391988","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL731557","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000921158.1","properties":[{"key":"ProteinId","value":"ENSP00000591217.1"},{"key":"GeneId","value":"ENSG00000165646.15"}]},{"database":"HGNC","id":"HGNC:10935","properties":[{"key":"GeneName","value":"SLC18A2"}]},{"database":"OpenTargets","id":"ENSG00000165646","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157593","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"CDD","id":"cd17384","properties":[{"key":"EntryName","value":"MFS_SLC18A1_2_VAT1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000083","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"InterPro","id":"IPR050930","properties":[{"key":"EntryName","value":"MFS_Vesicular_Transporter"}]},{"database":"PANTHER","id":"PTHR23506","properties":[{"key":"EntryName","value":"GH10249P"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23506:SF30","properties":[{"key":"EntryName","value":"SYNAPTIC VESICULAR AMINE TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIRMGMLASVYTDDEERGNVMGIALGGLAMGVLAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD","length":456,"molWeight":49856,"crc64":"E0497DD8BA5244DE","md5":"21A0EE23DB0B44549C21EED08804BFE2"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":10,"Domain":1},"uniParcId":"UPI004031EA0D"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8Q4C0","uniProtkbId":"A0ACI8Q4C0_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523738.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523738.1"}],"value":"Solute carrier family 18 member A2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523738.1"}],"value":"SLC18A2"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73739"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:59905"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034439"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:73740"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034439"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"serotonin(in) + 2 H(+)(out) = serotonin(out) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73743"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048115"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:73744"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048115"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane","id":"SL-0260"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006829"}],"value":"Belongs to the major facilitator superfamily. Vesicular transporter family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":274,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":301,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":342,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":362,"modifier":"EXACT"},"end":{"value":382,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":389,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":421,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":479,"modifier":"EXACT"},"end":{"value":501,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022775"}],"id":"KW-0532","category":"Biological process","name":"Neurotransmitter transport"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8Q4C0"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8Q4C0"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523738.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523738.1"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523738.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523738.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL391988","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL731557","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000853679.1","properties":[{"key":"ProteinId","value":"ENSP00000523738.1"},{"key":"GeneId","value":"ENSG00000165646.15"}]},{"database":"HGNC","id":"HGNC:10935","properties":[{"key":"GeneName","value":"SLC18A2"}]},{"database":"OpenTargets","id":"ENSG00000165646","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157593","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"CDD","id":"cd17384","properties":[{"key":"EntryName","value":"MFS_SLC18A1_2_VAT1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000083","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000116","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"InterPro","id":"IPR050930","properties":[{"key":"EntryName","value":"MFS_Vesicular_Transporter"}]},{"database":"PANTHER","id":"PTHR23506","properties":[{"key":"EntryName","value":"GH10249P"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23506:SF30","properties":[{"key":"EntryName","value":"SYNAPTIC VESICULAR AMINE TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR02045","properties":[{"key":"EntryName","value":"F138DOMAIN"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVERGFLHVGQPGLELLTSGDPPASASQSPGITVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD","length":545,"molWeight":58814,"crc64":"2B645FB868597860","md5":"718E889A413D2D2E53881104D3D1B543"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":11,"Domain":1},"uniParcId":"UPI0040315D91"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T2A3","uniProtkbId":"A0ACI8T2A3_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591216.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591216.1"}],"value":"Solute carrier family 18 member A2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591216.1"}],"value":"SLC18A2"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane","id":"SL-0260"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":156,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":418,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T2A3"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T2A3"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591216.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591216.1"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591216.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591216.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL391988","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL731557","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000921157.1","properties":[{"key":"ProteinId","value":"ENSP00000591216.1"},{"key":"GeneId","value":"ENSG00000165646.15"}]},{"database":"HGNC","id":"HGNC:10935","properties":[{"key":"GeneName","value":"SLC18A2"}]},{"database":"OpenTargets","id":"ENSG00000165646","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157593","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"CDD","id":"cd17384","properties":[{"key":"EntryName","value":"MFS_SLC18A1_2_VAT1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000083","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"InterPro","id":"IPR050930","properties":[{"key":"EntryName","value":"MFS_Vesicular_Transporter"}]},{"database":"PANTHER","id":"PTHR23506","properties":[{"key":"EntryName","value":"GH10249P"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23506:SF30","properties":[{"key":"EntryName","value":"SYNAPTIC VESICULAR AMINE TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD","length":484,"molWeight":52640,"crc64":"7DFAB0E93028DB90","md5":"E5705C7E40F0FEA85009117B8271BE7E"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":10,"Domain":1},"uniParcId":"UPI00403269CA"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8QNJ1","uniProtkbId":"A0ACI8QNJ1_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523736.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523736.1"}],"value":"Solute carrier family 18 member A2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523736.1"}],"value":"SLC18A2"}}],"comments":[{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73739"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:59905"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034439"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:73740"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00034439"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"serotonin(in) + 2 H(+)(out) = serotonin(out) + 2 H(+)(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:73743"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:350546"}],"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048115"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:73744"},"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00048115"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane","id":"SL-0260"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00006829"}],"value":"Belongs to the major facilitator superfamily. Vesicular transporter family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":223,"modifier":"EXACT"},"end":{"value":243,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":281,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":363,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":390,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":422,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":468,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":502,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":507,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023180"}],"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022775"}],"id":"KW-0532","category":"Biological process","name":"Neurotransmitter transport"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8QNJ1"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8QNJ1"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023018"}],"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523736.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523736.1"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523736.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000523736.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL391988","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL731557","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000853677.1","properties":[{"key":"ProteinId","value":"ENSP00000523736.1"},{"key":"GeneId","value":"ENSG00000165646.15"}]},{"database":"HGNC","id":"HGNC:10935","properties":[{"key":"GeneName","value":"SLC18A2"}]},{"database":"OpenTargets","id":"ENSG00000165646","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157593","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"CDD","id":"cd17384","properties":[{"key":"EntryName","value":"MFS_SLC18A1_2_VAT1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000083","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000116","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"InterPro","id":"IPR050930","properties":[{"key":"EntryName","value":"MFS_Vesicular_Transporter"}]},{"database":"PANTHER","id":"PTHR23506","properties":[{"key":"EntryName","value":"GH10249P"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23506:SF30","properties":[{"key":"EntryName","value":"SYNAPTIC VESICULAR AMINE TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR02045","properties":[{"key":"EntryName","value":"F138DOMAIN"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVERGFLHVGQPGLELLTSGDPPASASQSPGITVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD","length":546,"molWeight":58913,"crc64":"37F09994EBE965A8","md5":"EA102CBF8AEE1DC145491C32F5A29483"},"extraAttributes":{"countByCommentType":{"CATALYTIC ACTIVITY":2,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Transmembrane":11,"Domain":1},"uniParcId":"UPI0000F00416"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8T2K9","uniProtkbId":"A0ACI8T2K9_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591218.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591218.1"}],"value":"Solute carrier family 18 member A2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591218.1"}],"value":"SLC18A2"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane","id":"SL-0260"},"topology":{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00004644"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Transmembrane","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":359,"modifier":"EXACT"},"end":{"value":379,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":386,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Transmembrane","location":{"start":{"value":417,"modifier":"EXACT"},"end":{"value":439,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}]},{"type":"Domain","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Major facilitator superfamily (MFS) profile","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50850"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023329"}],"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00023136"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8T2K9"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8T2K9"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022692"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022989"},{"evidenceCode":"ECO:0000256","source":"SAM","id":"Phobius"}],"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022448"}],"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591218.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591218.1"}]},{"referenceNumber":3,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591218.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000591218.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL391988","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL731557","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000921159.1","properties":[{"key":"ProteinId","value":"ENSP00000591218.1"},{"key":"GeneId","value":"ENSG00000165646.15"}]},{"database":"HGNC","id":"HGNC:10935","properties":[{"key":"GeneName","value":"SLC18A2"}]},{"database":"OpenTargets","id":"ENSG00000165646","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000157593","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"CDD","id":"cd17384","properties":[{"key":"EntryName","value":"MFS_SLC18A1_2_VAT1_2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1250.20:FF:000083","properties":[{"key":"EntryName","value":"synaptic vesicular amine transporter isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1250.20","properties":[{"key":"EntryName","value":"MFS general substrate transporter like domains"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011701","properties":[{"key":"EntryName","value":"MFS"}]},{"database":"InterPro","id":"IPR020846","properties":[{"key":"EntryName","value":"MFS_dom"}]},{"database":"InterPro","id":"IPR036259","properties":[{"key":"EntryName","value":"MFS_trans_sf"}]},{"database":"InterPro","id":"IPR050930","properties":[{"key":"EntryName","value":"MFS_Vesicular_Transporter"}]},{"database":"PANTHER","id":"PTHR23506","properties":[{"key":"EntryName","value":"GH10249P"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23506:SF30","properties":[{"key":"EntryName","value":"SYNAPTIC VESICULAR AMINE TRANSPORTER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07690","properties":[{"key":"EntryName","value":"MFS_1"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF103473","properties":[{"key":"EntryName","value":"MFS general substrate transporter"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50850","properties":[{"key":"EntryName","value":"MFS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD","length":483,"molWeight":52602,"crc64":"8790B9AC139A8B55","md5":"510FF304F79A3720BC7A92728DAE6309"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Transmembrane":9,"Domain":1},"uniParcId":"UPI004031E54E"}}]}