{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P36021","secondaryAccessions":["Q7Z797"],"uniProtkbId":"MOT8_HUMAN","entryAudit":{"firstPublicDate":"1994-06-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-09-05","entryVersion":186,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Monocarboxylate transporter 8"},"shortNames":[{"value":"MCT 8"}]},"alternativeNames":[{"fullName":{"value":"Monocarboxylate transporter 7"},"shortNames":[{"value":"MCT 7"}]},{"fullName":{"value":"Solute carrier family 16 member 2"}},{"fullName":{"value":"X-linked PEST-containing transporter"}}]},"genes":[{"geneName":{"value":"SLC16A2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:10923"}],"value":"MCT7"},{"value":"MCT8"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"7981683"}],"value":"XPCT"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16887882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18337592"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628049"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23550058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26426690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27805744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28526555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31436139"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38661522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40140416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40368961"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40680733"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18636565"}],"value":"Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:16887882, PubMed:18337592, PubMed:20628049, PubMed:23550058, PubMed:27805744, PubMed:31436139, PubMed:26426690, PubMed:38661522, PubMed:40140416, PubMed:40368961, PubMed:40680733). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) (PubMed:28526555). Mediates the efflux of 3,5-diiodo-L-tyrosine (DIT) and 3-iodo-L-tyrosine (MIT) (PubMed:38661522)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71811"},{"database":"ChEBI","id":"CHEBI:533015"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16887882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18337592"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628049"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23550058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23610131"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26426690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27805744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31436139"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38661522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40140416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40680733"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-thyroxine(out) = L-thyroxine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71819"},{"database":"ChEBI","id":"CHEBI:58448"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16887882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18337592"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628049"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23550058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23610131"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26426690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27805744"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31436139"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38661522"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40368961"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40680733"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71815"},{"database":"ChEBI","id":"CHEBI:57261"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16887882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628049"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31436139"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:71823"},{"database":"ChEBI","id":"CHEBI:176514"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16887882"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628049"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31436139"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3,5-diiodo-L-tyrosine(in) = 3,5-diiodo-L-tyrosine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:82879"},{"database":"ChEBI","id":"CHEBI:57506"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38661522"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"3-iodo-L-tyrosine(in) = 3-iodo-L-tyrosine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:82883"},{"database":"ChEBI","id":"CHEBI:59898"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38661522"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19797118"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25527620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26426690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40140416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40368961"}],"value":"Monomer (PubMed:19797118, PubMed:26426690, PubMed:40368961). Homodimer (PubMed:19797118, PubMed:25527620, PubMed:26426690, PubMed:40140416). Homooligomer (PubMed:19797118, PubMed:40368961)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P36021","intActId":"EBI-20977483"},"interactantTwo":{"uniProtKBAccession":"Q9H0X4","geneName":"FAM234A","intActId":"EBI-1389842"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20628049"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23550058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25527620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26426690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40680733"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40680733"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18687783"}],"value":"Apical cell membrane","id":"SL-0015"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40680733"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18687783"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32143555"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7981683"}],"value":"Highly expressed in liver and heart (PubMed:7981683). In adult brain tissue expression is largely confined to endothelial cells of the blood-brain barrier (at protein level) (PubMed:18687783, PubMed:32143555)"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Monocarboxylate transporter 8 deficiency","diseaseAccession":"DI-01993","acronym":"MCT8 deficiency","description":"Consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects.","diseaseCrossReference":{"database":"MIM","id":"300523"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14661163"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15488219"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15889350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18636565"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23550058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25380603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25527620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26426690"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27805744"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.10"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18636565"}],"value":"Abnormal brain development associated with MCT8 deficiency may be the consequence of either decreased or increased intracellular T3 concentrations"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the major facilitator superfamily. 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