{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9BYW2","secondaryAccessions":["O75397","O75405","Q17RW8","Q5BKS9","Q5QGN2","Q69YI5","Q6IN64","Q6ZN53","Q6ZS25","Q8N3R0","Q8TCN0","Q9C0D1","Q9H696","Q9NZW9"],"uniProtkbId":"SETD2_HUMAN","entryAudit":{"firstPublicDate":"2006-10-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-05-18","entryVersion":202,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Histone-lysine N-methyltransferase SETD2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19332550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23043551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27474439"}],"value":"2.1.1.359"}]},"alternativeNames":[{"fullName":{"value":"HIF-1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16118227"}],"value":"Huntingtin yeast partner B"}},{"fullName":{"value":"Huntingtin-interacting protein 1"},"shortNames":[{"value":"HIP-1"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16118227"}],"value":"Huntingtin-interacting protein B"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19332550"}],"value":"Lysine N-methyltransferase 3A"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein-lysine N-methyltransferase SETD2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27518565"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28753426"}],"value":"2.1.1.-"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19332550"}],"value":"SET domain-containing protein 2"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19332550"}],"value":"hSET2"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11461154"}],"value":"p231HBP"}}]},"genes":[{"geneName":{"value":"SETD2"},"synonyms":[{"value":"HIF1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16118227"}],"value":"HYPB"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11214970"}],"value":"KIAA1732"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19332550"}],"value":"KMT3A"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19332550"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.7"}],"value":"SET2"}],"orfNames":[{"value":"HSPC069"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"E9Q5F9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16118227"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19141475"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21526191"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21792193"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23043551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23325844"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23622243"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24509477"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24843002"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27317772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27474439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27518565"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28753426"}],"value":"Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11461154"}],"value":"(Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60324"},{"database":"Rhea","id":"RHEA-COMP:9785"},{"database":"Rhea","id":"RHEA-COMP:15536"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61961"}],"ecNumber":"2.1.1.359","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19332550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23043551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27474439"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:51736"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:13053"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61929"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23043551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28753426"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54192"},{"database":"Rhea","id":"RHEA-COMP:9752"},{"database":"Rhea","id":"RHEA-COMP:13826"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61961"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27518565"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23043551"}],"value":"Specifically inhibited by sinefungin derivatives. N-propyl sinefungin (Pr-SNF) interacts preferentially with SETD2"}],"commentType":"ACTIVITY REGULATION"},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":1.21,"unit":"uM","substrate":"S-adenosyl-L-methionine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23043551"}]},{"constant":0.42,"unit":"uM","substrate":"histone H3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23043551"}]}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23043551"}],"value":"kcat is 0.14 min(-1)."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10958656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11461154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16118227"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16314571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18585004"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19141475"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19332550"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27518565"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28753426"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9700202"}],"value":"Specifically interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A): binds to CTD heptad repeats doubly phosphorylated on 'Ser-2' and 'Ser-5' of each heptad (PubMed:16118227, PubMed:16314571). Interacts with HTT (PubMed:10958656, PubMed:11461154, PubMed:9700202). Interacts with IWS1 (PubMed:19141475). Interacts with p53/TP53; leading to regulate p53/TP53 target genes (PubMed:18585004). Component of a complex with HNRNPL (PubMed:19332550, PubMed:36537238). Interacts with TUBA1A; the interaction is independent on alpha-tubulin acetylation on 'Lys-40' (PubMed:27518565). Interacts with STAT1 (PubMed:28753426)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BYW2","intActId":"EBI-945869"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BYW2","intActId":"EBI-945869"},"interactantTwo":{"uniProtKBAccession":"P84022","geneName":"SMAD3","intActId":"EBI-347161"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"E9Q5F9"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"E9Q5F9"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9BYW2-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9BYW2-2"],"sequenceIds":["VSP_020915"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9BYW2-3"],"sequenceIds":["VSP_020914"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11461154"}],"value":"Ubiquitously expressed"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16118227"}],"value":"The low charge region mediates the transcriptional activation activity"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27474439"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28256625"}],"value":"The catalytic SET domain binds histone H3 (PubMed:27474439, PubMed:28256625). It is also able to bind oncogenic histone H3 K36M/I found in a number of cancer types, in which histone H3 'Lys-36' is replaced by a Met or an Ile residue. When binding the oncogenic variant histone H3 K36M/I, the SET domain undergoes dramatic conformational change to accommodate the histone H3 peptide, leading to sequester and inhibit SETD2 activity and block global H3K36 methylation (PubMed:27474439, PubMed:28256625)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16118227"}],"value":"May be automethylated"}],"commentType":"PTM"},{"commentType":"DISEASE","disease":{"diseaseId":"Renal cell carcinoma","diseaseAccession":"DI-02254","acronym":"RCC","description":"Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype.","diseaseCrossReference":{"database":"MIM","id":"144700"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20054297"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23622243"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23792563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25728682"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23792563"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25728682"}],"value":"The disease may be caused by variants affecting the gene represented in this entry. Defects of SETD2 are associated with loss of DNA methylation at non-promoter regions (PubMed:23792563). SETD2 defects lead to aberrant and reduced nucleosome compaction and chromatin association of key replication proteins, such as MCM7 and DNA polymerase delta, leading to hinder replication fork progression and prevent loading of RAD51 homologous recombination repair factor at DNA breaks (PubMed:25728682)"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Luscan-Lumish syndrome","diseaseAccession":"DI-04661","acronym":"LLS","description":"An autosomal dominant syndrome with a variable phenotype. Clinical features include macrocephaly, distinctive facial appearance, postnatal overgrowth, various degrees of learning difficulties, autism spectrum disorder, and intellectual disability.","diseaseCrossReference":{"database":"MIM","id":"616831"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23160955"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24852293"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26084711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27317772"}]},"note":{"texts":[{"value":"The disease may be caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Leukemia, acute lymphoblastic","diseaseAccession":"DI-03076","acronym":"ALL","description":"A subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes.","diseaseCrossReference":{"database":"MIM","id":"613065"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24509477"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24662245"}]},"note":{"texts":[{"value":"The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Leukemia, acute myelogenous","diseaseAccession":"DI-01171","acronym":"AML","description":"A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.","diseaseCrossReference":{"database":"MIM","id":"601626"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16314571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24509477"}]},"note":{"texts":[{"value":"The disease may be caused by variants affecting distinct genetic loci, including the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Intellectual developmental disorder, autosomal dominant 70","diseaseAccession":"DI-06565","acronym":"MRD70","description":"An autosomal dominant disorder characterized by mild global developmental delay, moderately impaired intellectual disability with speech difficulties, and behavioral abnormalities.","diseaseCrossReference":{"database":"MIM","id":"620157"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32710489"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"DISEASE","disease":{"diseaseId":"Rabin-Pappas syndrome","diseaseAccession":"DI-06563","acronym":"RAPAS","description":"An autosomal dominant neurodevelopmental disorder characterized by severely impaired global development, intellectual disability, microcephaly, facial dysmorphism, and variable congenital anomalies affecting the skeletal, genitourinary, cardiac, and other organ systems.","diseaseCrossReference":{"database":"MIM","id":"620155"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32710489"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00190"}],"value":"Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAF29041.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous termination","sequence":"AAH72440.1","note":"Truncated C-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAI17163.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAI17165.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAT77612.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAT77613.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB15367.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAB15367.1","note":"Contaminating sequence. Potential poly-A sequence.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC87131.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous termination","sequence":"CAC28349.1","note":"Truncated C-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAD38601.2","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2564,"modifier":"EXACT"}},"description":"Histone-lysine N-methyltransferase 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