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Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11384978"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15053742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15853774"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21925150"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28296156"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7522053"}],"value":"Forms a heterodimer with TMPRSS7 (PubMed:15853774). Interacts with VTN (PubMed:7522053). Binds LRP1B; binding is followed by internalization and degradation (PubMed:11384978). Interacts with PPP1CB (PubMed:28296156). In complex with PLAU/uPA, interacts with PLAUR/uPAR (PubMed:15053742). Interacts with SORL1 and LRP1, either alone or in complex with PLAU; these interactions are abolished in the presence of LRPAP1/RAP (PubMed:15053742). The ternary complex composed of PLAUR-PLAU-PAI1 also interacts with SORL1 (PubMed:15053742). Interacts with PLAT/tPA (PubMed:21925150). Also interacts with SORL1, when complexed to PLAT/tPA (PubMed:15053742)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"Q8NBQ5","geneName":"HSD17B11","intActId":"EBI-1052304"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"P02763","geneName":"ORM1","intActId":"EBI-976767"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"P78337","geneName":"PITX1","intActId":"EBI-748265"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"P00749","geneName":"PLAU","intActId":"EBI-3905042"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"O43765","geneName":"SGTA","intActId":"EBI-347996"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"Q96EQ0","geneName":"SGTB","intActId":"EBI-744081"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"O43711","geneName":"TLX3","intActId":"EBI-3939165"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"Q96Q45-2","geneName":"TMEM237","intActId":"EBI-10982110"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"Q9UMX0","geneName":"UBQLN1","intActId":"EBI-741480"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"Q9UMX0-2","geneName":"UBQLN1","intActId":"EBI-10173939"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"Q9UHD9","geneName":"UBQLN2","intActId":"EBI-947187"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P05121","intActId":"EBI-953978"},"interactantTwo":{"uniProtKBAccession":"P04004","geneName":"VTN","intActId":"EBI-1036653"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2430793"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["P05121-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["P05121-2"],"sequenceIds":["VSP_045493"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"2430793"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"3097076"}],"value":"Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). 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The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.","diseaseCrossReference":{"database":"MIM","id":"613329"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8481516"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9207454"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29152572"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9207454"}],"value":"The disease is caused by variants affecting the gene represented in this entry. A rare PAI-1D mutation resulting in a frameshift and protein truncation has been found in an Old Order Amish community. Homozygous mutation carriers suffer from episodes of major hemorrhage, while heterozygous carriers do not manifest abnormal bleeding (PubMed:9207454). Heterozygosity for the mutation is associated with longer leukocyte telomere length, lower fasting insulin levels, lower prevalence of diabetes mellitus, and a longer life span (PubMed:29152572)"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the serpin family"}],"commentType":"SIMILARITY"},{"commentType":"WEB RESOURCE","resourceName":"Wikipedia","resourceUrl":"https://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1","ftp":false,"note":"Plasminogen activator inhibitor-1 entry"},{"commentType":"WEB RESOURCE","resourceName":"Protein Spotlight","resourceUrl":"https://www.proteinspotlight.org/back_issues/203/","ftp":false,"note":"Giving in to time - Issue 203 of May 2018"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":""},{"type":"Chain","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Plasminogen 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