{"results":[{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"P29034","secondaryAccessions":["O00266","Q3KRB9","Q5RHS8","Q9BU83"],"uniProtkbId":"S10A2_HUMAN","entryAudit":{"firstPublicDate":"1992-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-09-05","entryVersion":208,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein S100-A2"}},"alternativeNames":[{"fullName":{"value":"CAN19"}},{"fullName":{"value":"Protein S-100L"}},{"fullName":{"value":"S100 calcium-binding protein A2"}}]},"genes":[{"geneName":{"value":"S100A2"},"synonyms":[{"value":"S100L"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1372446"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22399290"}],"value":"May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18394645"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20188096"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22399290"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33831707"}],"value":"Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with TPPP; this interaction inhibits TPPP dimerization (PubMed:33831707)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"Q3SXY8","geneName":"ARL13B","intActId":"EBI-11343438"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P15311","geneName":"EZR","intActId":"EBI-1056902"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"Q5JX71","geneName":"FAM209A","intActId":"EBI-18304435"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"Q02790","geneName":"FKBP4","intActId":"EBI-1047444"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P52292","geneName":"KPNA2","intActId":"EBI-349938"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"Q00987","geneName":"MDM2","intActId":"EBI-389668"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"O15151","geneName":"MDM4","intActId":"EBI-398437"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P35579","geneName":"MYH9","intActId":"EBI-350338"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P23297","geneName":"S100A1","intActId":"EBI-743686"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P29034","geneName":"S100A2","intActId":"EBI-752230"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P33764","geneName":"S100A3","intActId":"EBI-1044747"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P04271","geneName":"S100B","intActId":"EBI-458391"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P04637","geneName":"TP53","intActId":"EBI-366083"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"Q8TD43","geneName":"TRPM4","intActId":"EBI-11723041"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P52293","geneName":"Kpna2","intActId":"EBI-3043908"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"P29034","intActId":"EBI-752230"},"interactantTwo":{"uniProtKBAccession":"P26882","geneName":"PPID","intActId":"EBI-6477155"},"numberOfExperiments":3,"organismDiffer":true}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1372446"}],"value":"A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9481475"}],"value":"Preferentially expressed in normal human mammary epithelial cells as opposed to tumor-derived ones. The level of S100L was shown to correlate inversely with tumor progression"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"1372446"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9481475"}],"value":"By growth factors in early G1 phase and probably by cell-cycle regulation in S phase. DNA methylation probably plays a direct negative role in suppressing S100L gene expression in tumor cells"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"This protein binds two calcium ions"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the S-100 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"It is uncertain whether Met-1 or Met-2 is the initiator"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA69033.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"WEB RESOURCE","resourceName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","resourceUrl":"https://atlasgeneticsoncology.org/gene/42191/S100A2","ftp":false}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Protein S100-A2","featureId":"PRO_0000143971"},{"type":"Domain","location":{"start":{"value":13,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Domain","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"EF-hand 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}]},{"type":"Binding site","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1","note":"low affinity"}},{"type":"Binding site","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000305"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"1","note":"low affinity"}},{"type":"Binding site","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2","note":"high affinity"}},{"type":"Binding site","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2","note":"high affinity"}},{"type":"Binding site","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2","note":"high affinity"}},{"type":"Binding site","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2","note":"high affinity"}},{"type":"Binding site","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108","label":"2","note":"high affinity"}},{"type":"Sequence conflict","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"in Ref. 1; M87068","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Helix","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DUQ"}]},{"type":"Beta strand","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DUQ"}]},{"type":"Helix","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DUQ"}]},{"type":"Helix","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DUQ"}]},{"type":"Helix","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DUQ"}]},{"type":"Beta strand","location":{"start":{"value":67,"modifier":"EXACT"},"end":{"value":71,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DUQ"}]},{"type":"Helix","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4DUQ"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"1372446","citationType":"journal article","authors":["Lee S.W.","Tomasetto C.","Swisshelm K.","Keyomarsi K.","Sager R."],"citationCrossReferences":[{"database":"PubMed","id":"1372446"},{"database":"DOI","id":"10.1073/pnas.89.6.2504"}],"title":"Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment.","publicationDate":"1992","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2504","lastPage":"2508","volume":"89"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","TISSUE SPECIFICITY","INDUCTION"],"referenceComments":[{"value":"Mammary epithelium","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"9481475","citationType":"journal article","authors":["Wicki R.","Franz C.","Scholl F.A.","Heizmann C.W.","Schaefer B.W."],"citationCrossReferences":[{"database":"PubMed","id":"9481475"},{"database":"DOI","id":"10.1016/s0143-4160(97)90063-4"}],"title":"Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation.","publicationDate":"1997","journal":"Cell Calcium","firstPage":"243","lastPage":"254","volume":"22"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","DEVELOPMENTAL STAGE","INDUCTION"]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"1286667","citationType":"journal article","authors":["Rasmussen H.H.","van Damme J.","Puype M.","Gesser B.","Celis J.E.","Vandekerckhove J."],"citationCrossReferences":[{"database":"PubMed","id":"1286667"},{"database":"DOI","id":"10.1002/elps.11501301199"}],"title":"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.","publicationDate":"1992","journal":"Electrophoresis","firstPage":"960","lastPage":"969","volume":"13"},"referencePositions":["PROTEIN SEQUENCE OF 37-40 AND 42-49"],"referenceComments":[{"value":"Keratinocyte","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"20188096","citationType":"journal article","authors":["Shimamoto S.","Kubota Y.","Tokumitsu H.","Kobayashi R."],"citationCrossReferences":[{"database":"PubMed","id":"20188096"},{"database":"DOI","id":"10.1016/j.febslet.2010.02.055"}],"title":"S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats.","publicationDate":"2010","journal":"FEBS Lett.","firstPage":"1119","lastPage":"1125","volume":"584"},"referencePositions":["INTERACTION WITH FKBP4"]},{"referenceNumber":7,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":8,"citation":{"id":"22399290","citationType":"journal article","authors":["Yamaguchi F.","Umeda Y.","Shimamoto S.","Tsuchiya M.","Tokumitsu H.","Tokuda M.","Kobayashi R."],"citationCrossReferences":[{"database":"PubMed","id":"22399290"},{"database":"DOI","id":"10.1074/jbc.m111.329771"}],"title":"S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.","publicationDate":"2012","journal":"J. Biol. Chem.","firstPage":"13787","lastPage":"13798","volume":"287"},"referencePositions":["FUNCTION IN CALCIUM SIGNALING","INTERACTION WITH PPP5C"]},{"referenceNumber":9,"citation":{"id":"18394645","citationType":"journal article","authors":["Koch M.","Diez J.","Fritz G."],"citationCrossReferences":[{"database":"PubMed","id":"18394645"},{"database":"DOI","id":"10.1016/j.jmb.2008.03.019"}],"title":"Crystal structure of Ca2+ -free S100A2 at 1.6-A resolution.","publicationDate":"2008","journal":"J. Mol. Biol.","firstPage":"933","lastPage":"942","volume":"378"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS)","SUBUNIT"]},{"referenceNumber":10,"citation":{"id":"33831707","citationType":"journal article","authors":["Doi S.","Fujioka N.","Ohtsuka S.","Kondo R.","Yamamoto M.","Denda M.","Magari M.","Kanayama N.","Hatano N.","Morishita R.","Hasegawa T.","Tokumitsu H."],"citationCrossReferences":[{"database":"PubMed","id":"33831707"},{"database":"DOI","id":"10.1016/j.ceca.2021.102404"}],"title":"Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins.","publicationDate":"2021","journal":"Cell Calcium","firstPage":"102404","lastPage":"102404","volume":"96"},"referencePositions":["INTERACTION WITH TPPP"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"M87068","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"Y07755","properties":[{"key":"ProteinId","value":"CAA69033.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BX470102","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC002829","properties":[{"key":"ProteinId","value":"AAH02829.3"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC105787","properties":[{"key":"ProteinId","value":"AAI05788.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS1044.2","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"A41988","properties":[{"key":"EntryName","value":"A41988"}]},{"database":"RefSeq","id":"NP_005969.2","properties":[{"key":"NucleotideSequenceId","value":"NM_005978.4"}]},{"database":"PDB","id":"2RGI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=1-98"}]},{"database":"PDB","id":"4DUQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.30 A"},{"key":"Chains","value":"A/B=1-98"}]},{"database":"PDBsum","id":"2RGI","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4DUQ","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"112181","properties":[{"key":"Interactions","value":"499"}]},{"database":"FunCoup","id":"P29034","properties":[{"key":"Number of interactors","value":"145"}]},{"database":"IntAct","id":"P29034","properties":[{"key":"Interactions","value":"358"}]},{"database":"MINT","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-S100A2","properties":[{"key":"Evidences","value":"5 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000499289","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB01373","properties":[{"key":"GenericName","value":"Calcium"}]},{"database":"DrugBank","id":"DB09130","properties":[{"key":"GenericName","value":"Copper"}]},{"database":"DrugBank","id":"DB00768","properties":[{"key":"GenericName","value":"Olopatadine"}]},{"database":"DrugBank","id":"DB01593","properties":[{"key":"GenericName","value":"Zinc"}]},{"database":"DrugBank","id":"DB14487","properties":[{"key":"GenericName","value":"Zinc acetate"}]},{"database":"DrugBank","id":"DB14533","properties":[{"key":"GenericName","value":"Zinc chloride"}]},{"database":"DrugBank","id":"DB14548","properties":[{"key":"GenericName","value":"Zinc sulfate, unspecified form"}]},{"database":"iPTMnet","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"S100A2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"114152869","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-1453","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000499289","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"PRIDE","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"54515","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34127","properties":[{"key":"antibodies","value":"273 antibodies from 33 providers"}]},{"database":"CPTC","id":"P29034","properties":[{"key":"antibodies","value":"3 antibodies"}]},{"database":"DNASU","id":"6273","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000368708.9","properties":[{"key":"ProteinId","value":"ENSP00000357697.4"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"Ensembl","id":"ENST00000368709.6","properties":[{"key":"ProteinId","value":"ENSP00000357698.2"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"Ensembl","id":"ENST00000368710.6","properties":[{"key":"ProteinId","value":"ENSP00000357699.2"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"Ensembl","id":"ENST00000487430.7","properties":[{"key":"ProteinId","value":"ENSP00000473260.2"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"Ensembl","id":"ENST00000883392.1","properties":[{"key":"ProteinId","value":"ENSP00000553451.1"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"Ensembl","id":"ENST00000930957.1","properties":[{"key":"ProteinId","value":"ENSP00000601016.1"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"Ensembl","id":"ENST00000930958.1","properties":[{"key":"ProteinId","value":"ENSP00000601017.1"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"Ensembl","id":"ENST00000930959.1","properties":[{"key":"ProteinId","value":"ENSP00000601018.1"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"Ensembl","id":"ENST00000930960.1","properties":[{"key":"ProteinId","value":"ENSP00000601019.1"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"Ensembl","id":"ENST00000930962.1","properties":[{"key":"ProteinId","value":"ENSP00000601021.1"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"GeneID","id":"6273","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:6273","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000368708.9","properties":[{"key":"ProteinId","value":"ENSP00000357697.4"},{"key":"RefSeqNucleotideId","value":"NM_005978.4"},{"key":"RefSeqProteinId","value":"NP_005969.2"}]},{"database":"UCSC","id":"uc001fcb.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:10492","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA34904","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6273","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"6273","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"S100A2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10492","properties":[{"key":"GeneName","value":"S100A2"}]},{"database":"HPA","id":"ENSG00000196754","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (esophagus, urinary bladder)"}]},{"database":"MIM","id":"176993","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000196754","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000196754","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S4AU","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000163114","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_138624_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EFFQGCP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"26525at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"P29034","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000196754","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"6273","properties":[{"key":"hits","value":"11 hits in 1148 CRISPR screens"}]},{"database":"ChiTaRS","id":"S100A2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"P29034","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"S100A2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"6273","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"P29034","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:P29034","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"P29034","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000196754","properties":[{"key":"ExpressionPatterns","value":"Expressed in tongue squamous epithelium and 137 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"P29034","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0048306","properties":[{"key":"GoTerm","value":"F:calcium-dependent protein binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16189514"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"22394450"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"25416956"},{"evidenceCode":"ECO:0000353","source":"PubMed","id":"32296183"}]},{"database":"GO","id":"GO:0046914","properties":[{"key":"GoTerm","value":"F:transition metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0043542","properties":[{"key":"GoTerm","value":"P:endothelial cell migration"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15313892"}]},{"database":"CDD","id":"cd00213","properties":[{"key":"EntryName","value":"S-100"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000044","properties":[{"key":"EntryName","value":"Protein S100"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR034325","properties":[{"key":"EntryName","value":"S-100_dom"}]},{"database":"InterPro","id":"IPR001751","properties":[{"key":"EntryName","value":"S100/CaBP7/8-like_CS"}]},{"database":"InterPro","id":"IPR013787","properties":[{"key":"EntryName","value":"S100_Ca-bd_sub"}]},{"database":"PANTHER","id":"PTHR11639:SF59","properties":[{"key":"EntryName","value":"PROTEIN S100-A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11639","properties":[{"key":"EntryName","value":"S100 CALCIUM-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01023","properties":[{"key":"EntryName","value":"S_100"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01394","properties":[{"key":"EntryName","value":"S_100"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00303","properties":[{"key":"EntryName","value":"S100_CABP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGSLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP","length":98,"molWeight":11117,"crc64":"56D09548450142A9","md5":"78F66052DB21BA1B2EDD1A473106765D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":16,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"INDUCTION":1,"MISCELLANEOUS":1,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":1,"WEB RESOURCE":1},"countByFeatureType":{"Chain":1,"Domain":2,"Binding site":7,"Sequence conflict":1,"Helix":5,"Beta strand":2},"uniParcId":"UPI0000169E1B"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"Q5RHS7","secondaryAccessions":["A6NDF0"],"uniProtkbId":"Q5RHS7_HUMAN","entryAudit":{"firstPublicDate":"2004-12-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-11-13","entryVersion":157,"sequenceVersion":3},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000357696.5"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000357696.5"}],"value":"S100 calcium binding protein A2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000357696.5"}],"value":"S100A2"}}],"features":[{"type":"Domain","location":{"start":{"value":6,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"S100/CaBP-9k-type calcium binding subdomain","evidences":[{"evidenceCode":"ECO:0000259","source":"SMART","id":"SM01394"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"Q5RHS7"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"Q5RHS7"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000357696.5"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000357696.5"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000357696.5"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000357696.5"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BX470102","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001353335.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001366406.1"}]},{"database":"RefSeq","id":"XP_047283329.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047427373.1"}]},{"database":"RefSeq","id":"XP_054194084.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054338109.1"}]},{"database":"AlphaFoldDB","id":"Q5RHS7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5RHS7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q5RHS7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"63738","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34127","properties":[{"key":"antibodies","value":"273 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000368707.5","properties":[{"key":"ProteinId","value":"ENSP00000357696.5"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"GeneID","id":"6273","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc057lbu.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"6273","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10492","properties":[{"key":"GeneName","value":"S100A2"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000196754","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000163114","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_2372157_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"26525at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"S100A2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000196754","properties":[{"key":"ExpressionPatterns","value":"Expressed in tongue squamous epithelium and 137 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q5RHS7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0046914","properties":[{"key":"GoTerm","value":"F:transition metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00213","properties":[{"key":"EntryName","value":"S-100"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR034325","properties":[{"key":"EntryName","value":"S-100_dom"}]},{"database":"InterPro","id":"IPR013787","properties":[{"key":"EntryName","value":"S100_Ca-bd_sub"}]},{"database":"PANTHER","id":"PTHR11639:SF59","properties":[{"key":"EntryName","value":"PROTEIN S100-A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11639","properties":[{"key":"EntryName","value":"S100 CALCIUM-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01023","properties":[{"key":"EntryName","value":"S_100"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01394","properties":[{"key":"EntryName","value":"S_100"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGHSREPCAVRAFRVHLFNPVIGDLRNQSPEGKSDCPKITQHWRKWMRRG","length":96,"molWeight":11101,"crc64":"EA3528D89EB86EBE","md5":"4A561648A3850A007E9698067E6273F4"},"extraAttributes":{"countByFeatureType":{"Domain":1},"uniParcId":"UPI0000F0467C"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"A0ACI8TK62","uniProtkbId":"A0ACI8TK62_HUMAN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2026-06-10","entryVersion":2,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601020.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361184"}],"value":"Protein S100"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361184"}],"value":"S100 calcium-binding protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601020.1"}],"value":"S100A2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007323"},{"evidenceCode":"ECO:0000256","source":"RuleBase","id":"RU361184"}],"value":"Belongs to the S-100 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"A0ACI8TK62"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"A0ACI8TK62"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022737"}],"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601020.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601020.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601020.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000601020.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BX470102","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"Ensembl","id":"ENST00000930961.1","properties":[{"key":"ProteinId","value":"ENSP00000601020.1"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"HGNC","id":"HGNC:10492","properties":[{"key":"GeneName","value":"S100A2"}]},{"database":"OpenTargets","id":"ENSG00000196754","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000163114","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"CDD","id":"cd00213","properties":[{"key":"EntryName","value":"S-100"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000044","properties":[{"key":"EntryName","value":"Protein S100"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR034325","properties":[{"key":"EntryName","value":"S-100_dom"}]},{"database":"InterPro","id":"IPR001751","properties":[{"key":"EntryName","value":"S100/CaBP7/8-like_CS"}]},{"database":"InterPro","id":"IPR013787","properties":[{"key":"EntryName","value":"S100_Ca-bd_sub"}]},{"database":"PANTHER","id":"PTHR11639:SF59","properties":[{"key":"EntryName","value":"PROTEIN S100-A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11639","properties":[{"key":"EntryName","value":"S100 CALCIUM-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01023","properties":[{"key":"EntryName","value":"S_100"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01394","properties":[{"key":"EntryName","value":"S_100"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00303","properties":[{"key":"EntryName","value":"S100_CABP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGKVDEEGLKKLMGSLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP","length":97,"molWeight":10988,"crc64":"3AFDBC37BE5ADBD0","md5":"367B4C8F1F66E0EA9D8B336FF0A3AA8D"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI004031BE92"}},{"entryType":"UniProtKB unreviewed (TrEMBL)","primaryAccession":"R4GN49","uniProtkbId":"R4GN49_HUMAN","entryAudit":{"firstPublicDate":"2013-06-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2013-06-26","entryVersion":73,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"submissionNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473489.1"}],"value":"S100 calcium binding protein A2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473489.1"}],"value":"S100A2"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00007323"}],"value":"Belongs to the S-100 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Domain","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000259","source":"PROSITE","id":"PS50222"}]}],"keywords":[{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022837"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0106","category":"Ligand","name":"Calcium"},{"evidences":[{"evidenceCode":"ECO:0000256","source":"ARBA","id":"ARBA00022723"},{"evidenceCode":"ECO:0000256","source":"PROSITE-ProRule","id":"PRU10142"}],"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"evidences":[{"evidenceCode":"ECO:0007829","source":"PeptideAtlas","id":"R4GN49"},{"evidenceCode":"ECO:0007829","source":"ProteomicsDB","id":"R4GN49"}],"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"evidences":[{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}],"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11237011","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"authors":["Lander E.S.","Linton L.M.","Birren B.","Nusbaum C.","Zody M.C.","Baldwin J.","Devon K.","Dewar K.","Doyle M.","FitzHugh W.","Funke R.","Gage D.","Harris K.","Heaford A.","Howland J.","Kann L.","Lehoczky J.","LeVine R.","McEwan P.","McKernan K.","Meldrim J.","Mesirov J.P.","Miranda C.","Morris W.","Naylor J.","Raymond C.","Rosetti M.","Santos R.","Sheridan A.","Sougnez C.","Stange-Thomann N.","Stojanovic N.","Subramanian A.","Wyman D.","Rogers J.","Sulston J.","Ainscough R.","Beck S.","Bentley D.","Burton J.","Clee C.","Carter N.","Coulson A.","Deadman R.","Deloukas P.","Dunham A.","Dunham I.","Durbin R.","French L.","Grafham D.","Gregory S.","Hubbard T.","Humphray S.","Hunt A.","Jones M.","Lloyd C.","McMurray A.","Matthews L.","Mercer S.","Milne S.","Mullikin J.C.","Mungall A.","Plumb R.","Ross M.","Shownkeen R.","Sims S.","Waterston R.H.","Wilson R.K.","Hillier L.W.","McPherson J.D.","Marra M.A.","Mardis E.R.","Fulton L.A.","Chinwalla A.T.","Pepin K.H.","Gish W.R.","Chissoe S.L.","Wendl M.C.","Delehaunty K.D.","Miner T.L.","Delehaunty A.","Kramer J.B.","Cook L.L.","Fulton R.S.","Johnson D.L.","Minx P.J.","Clifton S.W.","Hawkins T.","Branscomb E.","Predki P.","Richardson P.","Wenning S.","Slezak T.","Doggett N.","Cheng J.F.","Olsen A.","Lucas S.","Elkin C.","Uberbacher E.","Frazier M.","Gibbs R.A.","Muzny D.M.","Scherer S.E.","Bouck J.B.","Sodergren E.J.","Worley K.C.","Rives C.M.","Gorrell J.H.","Metzker M.L.","Naylor S.L.","Kucherlapati R.S.","Nelson D.L.","Weinstock G.M.","Sakaki Y.","Fujiyama A.","Hattori M.","Yada T.","Toyoda A.","Itoh T.","Kawagoe C.","Watanabe H.","Totoki Y.","Taylor T.","Weissenbach J.","Heilig R.","Saurin W.","Artiguenave F.","Brottier P.","Bruls T.","Pelletier E.","Robert C.","Wincker P.","Smith D.R.","Doucette-Stamm L.","Rubenfield M.","Weinstock K.","Lee H.M.","Dubois J.","Rosenthal A.","Platzer M.","Nyakatura G.","Taudien S.","Rump A.","Yang H.","Yu J.","Wang J.","Huang G.","Gu J.","Hood L.","Rowen L.","Madan A.","Qin S.","Davis R.W.","Federspiel N.A.","Abola A.P.","Proctor M.J.","Myers R.M.","Schmutz J.","Dickson M.","Grimwood J.","Cox D.R.","Olson M.V.","Kaul R.","Raymond C.","Shimizu N.","Kawasaki K.","Minoshima S.","Evans G.A.","Athanasiou M.","Schultz R.","Roe B.A.","Chen F.","Pan H.","Ramser J.","Lehrach H.","Reinhardt R.","McCombie W.R.","de la Bastide M.","Dedhia N.","Blocker H.","Hornischer K.","Nordsiek G.","Agarwala R.","Aravind L.","Bailey J.A.","Bateman A.","Batzoglou S.","Birney E.","Bork P.","Brown D.G.","Burge C.B.","Cerutti L.","Chen H.C.","Church D.","Clamp M.","Copley R.R.","Doerks T.","Eddy S.R.","Eichler E.E.","Furey T.S.","Galagan J.","Gilbert J.G.","Harmon C.","Hayashizaki Y.","Haussler D.","Hermjakob H.","Hokamp K.","Jang W.","Johnson L.S.","Jones T.A.","Kasif S.","Kaspryzk A.","Kennedy S.","Kent W.J.","Kitts P.","Koonin E.V.","Korf I.","Kulp D.","Lancet D.","Lowe T.M.","McLysaght A.","Mikkelsen T.","Moran J.V.","Mulder N.","Pollara V.J.","Ponting C.P.","Schuler G.","Schultz J.","Slater G.","Smit A.F.","Stupka E.","Szustakowski J.","Thierry-Mieg D.","Thierry-Mieg J.","Wagner L.","Wallis J.","Wheeler R.","Williams A.","Wolf Y.I.","Wolfe K.H.","Yang S.P.","Yeh R.F.","Collins F.","Guyer M.S.","Peterson J.","Felsenfeld A.","Wetterstrand K.A.","Patrinos A.","Morgan M.J.","de Jong P.","Catanese J.J.","Osoegawa K.","Shizuya H.","Choi S.","Chen Y.J."],"citationCrossReferences":[{"database":"PubMed","id":"11237011"},{"database":"DOI","id":"10.1038/35057062"}],"title":"Initial sequencing and analysis of the human genome.","publicationDate":"2001","journal":"Nature","firstPage":"860","lastPage":"921","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":2,"citation":{"id":"15496913","citationType":"journal article","authoringGroup":["International Human Genome Sequencing Consortium"],"citationCrossReferences":[{"database":"PubMed","id":"15496913"},{"database":"DOI","id":"10.1038/nature03001"}],"title":"Finishing the euchromatic sequence of the human genome.","publicationDate":"2004","journal":"Nature","firstPage":"931","lastPage":"945","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":3,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.","McLaren S.","Milne S.","Mistry S.","Moore M.J.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R.","Banerjee R.","Bryant S.P.","Burford D.C.","Burrill W.D.","Clegg S.M.","Dhami P.","Dovey O.","Faulkner L.M.","Gribble S.M.","Langford C.F.","Pandian R.D.","Porter K.M.","Prigmore E."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473489.1"},{"evidenceCode":"ECO:0000313","source":"Proteomes","id":"UP000005640"}]},{"referenceNumber":4,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Burckstummer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"evidences":[{"evidenceCode":"ECO:0007829","source":"PubMed","id":"21269460"}]},{"referenceNumber":5,"citation":{"id":"CI-20IM145UGQVF7","citationType":"submission","authoringGroup":["Ensembl"],"publicationDate":"JAN-2026","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION"],"evidences":[{"evidenceCode":"ECO:0000313","source":"Ensembl","id":"ENSP00000473489.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BX470102","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_001353336.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001366407.1"}]},{"database":"AlphaFoldDB","id":"R4GN49","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"R4GN49","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"R4GN49","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34127","properties":[{"key":"antibodies","value":"273 antibodies from 33 providers"}]},{"database":"Ensembl","id":"ENST00000497140.5","properties":[{"key":"ProteinId","value":"ENSP00000473489.1"},{"key":"GeneId","value":"ENSG00000196754.14"}]},{"database":"GeneID","id":"6273","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc057lbr.1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"CTD","id":"6273","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:10492","properties":[{"key":"GeneName","value":"S100A2"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000196754","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00940000163114","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_207387_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"26525at2759","properties":[{"key":"Description","value":"-"}]},{"database":"ChiTaRS","id":"S100A2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"Bgee","id":"ENSG00000196754","properties":[{"key":"ExpressionPatterns","value":"Expressed in tongue squamous epithelium and 137 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"R4GN49","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046914","properties":[{"key":"GoTerm","value":"F:transition metal ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"CDD","id":"cd00213","properties":[{"key":"EntryName","value":"S-100"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011992","properties":[{"key":"EntryName","value":"EF-hand-dom_pair"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR034325","properties":[{"key":"EntryName","value":"S-100_dom"}]},{"database":"InterPro","id":"IPR001751","properties":[{"key":"EntryName","value":"S100/CaBP7/8-like_CS"}]},{"database":"PANTHER","id":"PTHR11639:SF59","properties":[{"key":"EntryName","value":"PROTEIN S100-A2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11639","properties":[{"key":"EntryName","value":"S100 CALCIUM-BINDING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47473","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00303","properties":[{"key":"EntryName","value":"S100_CABP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKELLHKELPSFVGEKVDEEGLKKLMGSLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP","length":64,"molWeight":7324,"crc64":"0EC753C680095EC9","md5":"D365F8B367E6E918E7F5A2D9C8625085"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Domain":1},"uniParcId":"UPI00024CC7E1"}}]}